Publications

equine markers genes. polymorphism for group-specific component (gc).	polymorphism of equine gc protein was demonstrated by immunofixation electrophoresis with a goat anti-human gc antibody. three different phenotypes, f, fs and s, were found. family data supported the genetic theory of two autosomal codominant alleles, gcf and gcs. both alleles occurred in standardbred, thoroughbred and arabian horses and in shetland ponies. a frequency of 0.23 for gcs in the american standardbred horse indicates the system should be useful for problems of identification and pare ...	1978	84540
[effect of s-adenosyl-l-methionine on the cerebral and peripheral metabolism of l-dopa].	the repartition of [3h]l-dopa administered i.p. does not change in rats treated with s-adenosyl-l-methionine (sam). the effect was studied on the central nervous system and at the periphery. the biosynthesis of metabolites [3h]dopamine and [3h]3-o-methyldopamine are also unchanged. on the other hand, in the kidney an accumulation of [3h]norepinephrine +[3h]normetanephrine was observed, while in the brainstem + midbrain the synthesis of these metabolites was decreased after sam injection. the rel ...	1978	84550
akaline phosphatase: activity and variation in human diploid fibroblasts.	a method is introduced for the assay of alkaline phosphatase in homogenates of cultured human skin fibroblasts. in a first group of 11 strains, a four- to fifteen-fold increase of enzyme activity is consistently observed following a period of starvation. in the remaining 31 cell-strains similar specific activities of alkaline phosphatase are found irrespective of medium changes. in regularly fed cultures, an inverse exponential correlation between the specific activity of alkaline phosphatase an ...	1978	84560
purification and preliminary characterization of protease b from saccharomyces cerevisiae [proceedings].		1978	84637
studies on the mechanism of goitrogenic action of diphenylthiohydantoin.	diphenylthiohydantoin (dpth) is a potent goitrogenic compound and produces goiters in rats. like methimazole, dpth depresses plasma t4 and t3 concentrations and elevates plasma t4 and t3 concentrations and elevates plasma tsh concentration. unlike methimazole, however, dpth does not suppress thyroidal radioiodine uptake and thyroid hormone synthesis, although the monoiodotyrosine to diiodotyrosine ration is elevated by dpth. dpth does not inhibit thyroidal radioiodine release or augment the degr ...	1978	84751
deoxycytidine: a morphine antagonist.	deoxycytidine antagonizes the analgesic action of morphine in the rat, morphine-induced respiratory depression in the rabbit and mitigates withdrawal in the dependent mouse. administration of deoxycytidine does not precipitate the abstinence syndrome in dependent mice, a property shared by certain other endogenous morphine antagonsits. cytidine and thymidine closely related in structure to deoxycytidine, are interchangeable with saline as controls, indicating a high degree of specificity in the ...	1978	28700
the increasing incidence of ampicillin-resistant haemophilus influenzae. a cause of otitis media.	middle ear exudate was obtained by myringotomy or aspiration from 625 suburban children, aged 1 month to 12 years, who had acute otitis media; bacterial pathogens were isolated from 71%. haemophilus species were isolated from 212 (29%), and streptococcus pneumoniae from 205 (28%). from 1975 to august 1977, the number of haemophilus isolates found to be resistant to ampicillin has appreciably increased. currently, 8% of all cases of acute otitis media in the washington, dc, area are due to h infl ...	1978	22767
effect of growth conditions on the antigenic components of streptococcus mutans and lactobacilli.	1) the release of lta from chemostat-grown cultures of s. mutans and l. fermentum is dependent on the generation time and ph. 2) the growth rate affects the immunogenicity of lta and the wall polysaccharide of l. fermentum. 3) the growth of l. plantarum under glucose limitation influences the glucose content of the wall teichoic acid. the composition of the wall polysaccharide of s. mutans ingbritt may also be changed under these conditions. 4) the conditions of autoclaving used to release cell ...	1978	33543
report of iabs committee on avian product standardization.	the international association of biological standardization (iabs) organized an international symposium in august 1973 on the "requirements for poultry virus vaccines" at lyon (france). the proceedings of this symposium were subsequently published as "developments in biological standardization", volume 25. at the conclusion of this symposium, it was resolved that an avian biological products standardization committee should be established, this committee including four subcommittees, each under ...	1978	38158
[immunostimulation].		1978	84450
comparison of counter-current immunoelectrophoresis, latex agglutination, and radioimmunoassay in detection of soluble capsular polysaccharide antigens of haemophilus influenzae type b and neisseria meningitidis of groups a or c.	three serological methods, radioimmunoassay (ria), latex agglutination (lx), and counter-current immunoelectrophoresis (ciep), for sensitivity in the detection of the capsular polysaccharide antigen of haemophilus influenzae type b or neisseria meningitidis groups a and c were compared. ria was consistently the most sensitive, lx the next, and ciep the least sensitive. when ria and lx were used to test cerebrospinal fluid (csf) samples of patients with meningitis, they gave very similar results. ...	1978	85636
effects of phosphodiesterase inhibitors, imidazole and phosphate on cyclic cmp phosphodiesterase are different from those on cyclic amp and cyclic gmp phosphodiesterases.	the effects of various agents on the newly identified cyclic cmp phosphodiesterase (c-pde) in crude extracts of a number of rat tissues and on the enzyme partially purified from the rat liver were examined. papaverine and 1-methyl-3-isobutylxanthine were without effects on c-pde at concentrations that inhibited up to 90% of cyclic amp phosphodiesterase (a-pde) and cyclic gmp phosphodiesterase (g-pde) activities. when assayed using 1 micron substrates, theophylline inhibited c-pde to a lesser ext ...	1978	85641
ultrastructure of peptidergic neurosecretory axons in the developing neural lobe of the rat.		1978	86479
[perichordal necroses. contribution to the understanding of the spinal column morphogenesis].	in 12--15 days old rat embryos and 12 days old mouse embryos vitally stained by acridin orange, a perichordal necrosis appears, showing metameric intensifications at the level of the dense sclerotomites. similar aspects were detected in serially sectioned rabbit and human embryos (6--7 mm c.r. length). the authors correlate the necrotic zones mentioned with the inductive functions of the notochord.	1978	86154
uptake of iron by duodenal biopsy specimens from patients with iron-deficiency anaemia and primary haemochromatosis.	iron uptake by human duodenal mucosa in vitro was considerably higher in iron-deficient patients than in controls. in biopsy specimens taken after treatment with iron, uptake fell to normal levels, although total iron in the mucosa remained low. in iron-overloaded patients with primary haemochromatosis, there was inappropriately high uptake of iron by the biopsy specimens. kinetic analysis suggested that this was the result of affinity for iron being increased in a carrier in the enterocyte.	1978	87554
pneumococcal vaccines.		1978	87558
4th international workshop on human gene mapping. report of the committee on the genetic constitution of the x and y chromosomes.		1978	88299
determinant selection and macrophage function in genetic control of the immune response.	the immune response to insulin, in both mouse and guinea pig, is under control of h-linked immune response genes. when immunized with either pork or beef insulin in cfa, both strain 2 and 13 guinea pigs respond by antigen-specific lymphocyte proliferation and synthesis of specific antibody. the specificities of the elicited antibodies and indistinguishable between these inbred strains. by constrast, strain 2 t cells recognized a distinct region of the a chain alpha loop consisting of amino acid ...	1978	89077
[experimental inductions of tissue alterations in the lung following bleomycin and irradiation exposure (author's transl)].		1978	88746
[post-extrasystolic and post-pacing potentiation. ii. study by means of systolic time intervals in man].		1978	88948
leukogenic properties of purified blv and possible routes of its transmission with blood cells present in milk.	the results of five years studies on the possibility of experimental induction of bovine leukemia with purified blv and different blv-containing materials demonstrated that inoculation of calves with purified blv (structures of 1.14-1.17 g/ml density in 20-60% sucrose gradient) can induce oncornavirus infection and bovine leukemia. from 41 experimentally infected calves 9 showed evidence of bovine leukemia. 5 of these 9 animals were from a group of 22 calves inoculated with purified blv. diagnos ...	1978	89827
comparative experimental studies in animals and humans on gastrointestinal blood loss following antirheumatic pharmacotherapy (author's transl).	the gastrointestinal blood loss caused by the two antirheumatic drugs acetyl salicylic acid (asa) and 4-acetamidophenyl-2-acetoxybenzoate (benorilate, benortan) was compared in experimental animals and humans by measuring the total body iron retention. in wistar rats and humans the results indicate that the daily iron loss under asa is significantly higher (almost by the factor 2) than that under benorilate.	1978	26360
antibiotic resistance in streptococcus pneumoniae and haemophilus influenzae. report of a study group on bacterial resistance.	twenty laboratories in england and scotland took part in 1977 in a survey of antibiotic resistance in streptococcus pneumoniae and haemophilus influenzae. in str pneumoniae 59 (6.8%) of the 866 strains studied were resistant to tetracycline and three to chloramphenicol, and one strain showed a decreased susceptibility to penicillin. the prevalence of resistance to tetracycline was lower than that found in a similar study performed in 1975. nine hundred and fifty-two strains of h influenzae were ...	1978	26450
the metabolism of (2-cyclopentyl-6,7-dichloro-2-methyl-1-oxo-5-indanyloxy)acetic acid in chimpanzee and man.	the metabolism of the polyvalent saluretic agent (2-cyclopentyl-6,7-dichloro-2-methyl-1-oxo-5-indanyloxy)acetic acid was studied in chimpanzee and man. the drug was well absorbed and extensively metabolized by man. peak levels of drug (5--8 microgram/ml) occurred within 1.5--4.5 hr of drug administration. the plasma half-life was estimated to be 2 hr; a similar half-life was observed in the chimpanzee. little unchanged drug (less than 10%) was excreted in the urine of either species. similar met ...	1978	26552
effect of amisyl and spasmolytin on the blood supply and oxygen metabolism of the brain.	the effect of benactyzine and spasmolytin adiphenine on the blood circulation in the oxygen consumption by the brain were investigated in experiments on dogs. the resulting data point to a biphasic action of benacyzine and spasmolytin on the blood supply of the brain (after a short-lived increase of the blood flow a clearcut decline of it is noted). the oxygen intake from the blood varies irregularly. in chlorophos-poisoned dogs the oxygen absorption by the brain changes under the effect of bena ...	1978	26597
bacterial etiology of otitis media during the first six weeks of life.	tympanocentesis was performed on 70 infants who had otitis media during the first six weeks of life. the bacteria isolated from their middle-ear effusions were streptococcus pneumoniae (13 patients), neisseria catarrhalis (11 patients), hemophilus influenzae (ten patients), enterobacteriaceae (four patients), staphylococcus aureus (four patients), streptococci (groups a and b) (three patients), and pseudomonas aeruginosa (two patients). thirty patients (42.9%) had middle-ear effusions which did ...	1978	26735
a modified agar diffusion assay for amphotericin b.		1978	26759
type-iii allergic reactivity to diplococcus pneumoniae and encapsulated haemophilus influenzae in passively sensitized mice and rats.		1978	26860
effect of prior antibiotic therapy on concentrations of bacteria in csf.	a prospective study was done to determine the effect of prior antibiotic therapy on concentrations of bacteria in csf at the time of diagnosis. concentrations of haemophilus influenzae type b in csf of partially treated patients were significantly smaller than in csf of untreated patients. this was also true of patients with meningococcal meningitis, but no difference was observed between patients with pneumococcal meningitis. the identification of h influenzae by gram stain of csf was significa ...	1978	27090
neurochemical anatomy of the neuroendocrine hypothalamus. neurochemical anatomy of the hypothalamus.	microdissection techniques for isolated removal of the various regions of the hypothalamus as well as the individual hypothalamic nuclei are detailed. recent development of biochemical microassays have made it possible that the concentrations of neurohormones, neuropeptides, neurotransmitters and their related enzymes could be detected in such a small volume of brain tissue than the hypothalamic nuclei. data available of the hypothalamic distribution of above substances are summarized. the possi ...	1978	27266
immuno-stimulation by a ribosomal vaccine associated with a bacterial cell wall adjuvant in humans.	we have studied a new vaccine of ribosomal nature associated with glycoprotein cell walls from klebsiella pneumoniae which served as an immunoadjuvant. thus vaccine was administered by the aerosol route to working men free of any important disease, especially of respiratory disease. a total of 104 men working for the commissariat à l'energie atomique, all volunteers, were randomly placed into two groups. during the first period, 51 patients (group i) were vaccinated three times a week during 5 w ...	1978	27461
red cell oxygen affinity in fetal sheep: role of 2,3-dpg and adult hemoglobin.	studies were carried out during fetal life in sheep to determine the relationship of 2,3-diphosphoglycerate (dpg), the intracellular red cell and extracellular ph, and the switchover to adult hemoglobin synthesis in regulating the position of the fetal red cell oxygen-affinity curve in utero. adult hemoglobin first appeared near 120 days of gestation. the mean oxygen tension at which hemoglobin is half saturated (p50) prior to 120 days of gestation remained constant at 13.9 +/- 0.3 (sd) torr and ...	1978	27486
epr investigation of the mn(ii) binding sites in glutamine synthetase (escherichia coli w). i. high-affinity binding sites.		1978	27502
the leeuwenhoek lecture, 1977. mouse teratocarcinoma and mouse embryo.		1978	27802
tissue ph measurement proceedings.		1978	28161
na+-k+-activated adenosinetriphosphatase as a trigger in transmitter release.		1978	28496
a spectral probe near the subunit catalytic site of glutamine synthetase from escherichia coli. reduced pyridoxal 5'-phosphate.enzyme complexes.	in order to label phosphate binding sites, unadenylylated glutamine synthetase from escherichia coli has been pyridoxylated by reacting the enzyme with pyridoxal 5'-phosphate followed by reduction of the schiff base with nabh4. a complete loss in mg2+-supported activity is associated with the incorporation of 3 eq of pyridoxal-p/subunit of the dodecamer. at this extent of modification, however, the pyridoxylated enzyme exhibits substantial mn2+-supported activity (with increased km values for at ...	1978	29046
state and rhythmic processes.		1978	29061
otitis media in infants less than 12 weeks of age: differing bacteriology among in-patients and out-patients.		1978	29086
the midwife and human prosperity.		1978	29283
evaluation of the counterimmunoelectrophoretic (cie) procedure in a clinical laboratory setting.	the counterimmunoelectrophoretic (cie) procedure was evaluated under clinical laboratory conditions to determine its validity and comparability with culture methods. the procedure was further evaluated to determine applicability to a variety of clinical samples. an inexpensive set-up was developed to utilize the cie procedure at bench level. results indicated the procedure to be sensitive in detecting haemophilus influenzae, type b, and neisseria meningitidis (meningococcus), group b. the proced ...	1978	29483
antibiotic resistance in streptococcus pneumoniae and haemophilus influenzae.		1978	29689
effects of psychotropic drugs on the spinal ventral root reflexes in cats. a comparison of the depressant actions in intact and spinal preparations (author's transl).	effects of the typical psychotropic drugs such as neuroleptics, tricyclic antidepressants and benzodiazepines on the monosynaptic reflex (msr) and polysynaptic reflex (psr) were investigated using intact and spinal cats. drugs used were chlorpromazine, levomepromazine, perphenazine, prochlorperazine, droperidol, haloperidol, amitriptyline, imipramine, diazepam and flurazepam. neuroleptics depressed the ventral root reflexes markedly to slightly in both preparations. the inhibitory effects of the ...	1978	29826
viruses and bacteria associated with acute respiratory illnesses in young children in general practice.	the results obtained and the laboratory methods used for the isolation of viruses and bacteria from malaysian children with acute respiratory illnesses seen in a private clinic are described. of the 65 children studied virus isolations were obtained from 26 children, bacteria from 10 and both virus and bacteria from another 5. the agents isolated were influenza viruses, parainfluenza viruses, adenoviruses, bordetella pertussis, streptococcus pneumoniae, haemophilus influenzae and staphylococcus ...	1978	30173
bacteriology of maxillary sinusitis in relation to quality of the retained secretion.	the bacteriological findings in 200 patients with acute maxillary sinusitis are reported. it is concluded that the sampling technique--by antral aspiration--is highly significant in the evaluation of the bacteriological background of sinusitis, whereas the anerobic transport of the sample seems to be of less importance. by aspiration the purulent secretion can be properly separated from the non-purulent secretion. pneumococci, h. influenzae and anaerobic bacteria can be isolated in about 90% of ...	1978	30255
bacterial meningitis: the beginning of the end.		1978	30281
antibiotic resistance in streptococcus pneumoniae and haemophilus influenzae.		1978	30516
european society of human genetics. abstracts from symposium on "chromosome structure and function". vienna, austria, may 5-7, 1978.		1978	30557
dipeptidylaminopeptidase and carboxypeptidase activities of the brush border of rabbit small intestine.		1978	30675
the absorption and sputum penetration of doxycycline.		1978	30746
microbiology of recurrent and chronic otitis media with effusion.	a study was conducted of 274 children who had recurrent acute or chronic otitis media with effusion. forty-five percent of the ears with effusion were found to contain bacteria, and 11% contained bacteria that were "probable pathogens" (s. pneumoniae, h. influenzae, and s. pyogenes). bacteria were also found in 40% of the ears without effusions. the type of organism found did not vary with the age of the patient studied or the season of the year. the significance of these bacteria in the etiolog ...	1978	30809
treatment of acute otitis media of infancy with cefaclor.	the emergence of ampicillin-resistant haemophilus as a clinical problem in otitis media necessitates a search for alternative, effective therapy. an orally absorbable cephalosporin derivative, cefaclor, is equally effective in vitro against ampicillin-susceptible and -resistant haemophilus and against other bacteria that cause acute otitis media. two dosage schedules of cefaclor (40 and 60 mg/kg/day) were evaluated in 95 infants with acute otitis media. bacterial origin was determined by a cultu ...	1978	31084
[the intragastral antibacterial effect and its importance in chronic enterocolitis].		1978	31275
(exo, exo)-2-aryltropane-3-carboxylic esters, hypoglycemic agents with accompanying analgesic activity.	(exo, exo)-2-aryltropane-3-carboxylic esters of types 6, 7, and 10 lower circulating blood glucose levels by 60--80%. this activity is accompanied by an analgesic activity roughly equal to that of codeine. both of these activities reside in the 1r enantiomer and extensive structure-activity studies failed to separate them. the specific opioid antagonist nalorphine blocks the analgesic activity but does not diminish the hypoglycemic action. conformational integrity afforded by the ethylene bridge ...	1978	31482
[the efficacy of a maintenance dose of 100 mg doxycycline (vibramycin) daily in bacterial infections of chronic bronchitis (author's transl)].	the efficacy and tolerance of a daily maintenance dose of 100 mg doxycycline (vibramycin) was investigated in ambulant patients with chronic obstructive pulmonary disease (copd) and bacterial infection by an open study with clinical, bacteriological and cytological control. the dosage was well tolerated and effective in the elimination of h. influenzae and pneumococci. a higher maintenance dose seems not to be necessary for this type of infections.	1978	31554
[treatment of chronic bronchitis with supristol and a cotrimoxazole preparation--comparative bacteriological and clinical findings, results of a double-blind study (author's transl)].	in a randomized double-blind study on the treatment of chronic bronchitis, supristol (co-trifamole) was compared with co-trimoxazole. 163 patients participated in the clinical trial that was performed at three different hospitals in accordance with a uniform trial plan. the microbiological investigations were done centrally at a hygiene institute for all three hospitals. the bacteriological results from the 61 patients whose antibiogram revealed sensitive pathogens before starting the therapy de ...	1978	31555
the use of bacteria for the functional characterization of human lymphocyte subpopulations in various lymphoid organs.	in a haemolytic plaque assay staphylococcal strain cowan 1 was shown to induce polyclonal antibody secretion in human blood lymphocytes, whereas haemophilus influenzae and escherichia coli gave low responses. diplococcus pneumoniae and haemolytic streptococci generally did not activate blood cells. all five bacteria could activate spleen, tonsil and adenoid cells both to polyclonal ig secretion and increased dna synthesis. thus blood cell reactivity does not necessarily reflect the response patt ...	1978	31677
serological methods for rapid diagnosis of haemophilus influenzae, neisseria meningitidis and streptococcus pneumoniae in cerebrospinal fluid: a comparison of co-agglutination, immunofluorescence and immunoelectroosmophoresis.		1978	31678
hr 756, the syn isomer of a new methoxyimino cephalosporin with unusual antibacterial activity.	hr 756, the syn derivative of 7-[(2-(2-amino-4-thiazolyl)-2-methoxyimino)acetamido]cephalosporanic acid, is a new semisynthetic cephalosporin. it was 80 times more active than the anti derivative against beta-lactamase-producing strains of gram-negative bacteria. the range of inhibitory concentrations of hr 756 against gram-negative bacteria, including haemophilus influenzae, susceptible or resistant to penicillins and cephalosporins was from 0.01 to 0.1 mug/ml. this activity was consistently hi ...	1978	31836
inhibition of growth and guanylate cyclase activity of an undifferentiated prostate adenocarcinoma by an extract of the balsam pear (momordica charantia abbreviata).	we have recently described the presence of a guanylate cyclase gtp pyrophosphate-lyase (cyclizing), ec 4.6.1.2 inhibitor (gci) in an aqueous extract of the balsam pear (momordica charantia abbreviata). because the guanylate cyclase-cyclic gmp system is though to be involved in cell growth, dna and rna synthesis, and possible malignant transformation, we examined the effect of the aqueous extract containing gci on an undifferentiated adenocarcinoma of the rat prostate and concanavalin-a-stimulate ...	1978	24847
exacerbations of chronic bronchitis: exogenous or endogenous infection?	six male patients with chronic bronchitis, who were known previously to have excreted streptococcus pneumoniae and/or haemophilus influenzae, both at the times of exacerbations and during remission, were studied for 43 to 52 months. sputum was examined fortnightly and at the time of exacerbations. strains of strep. pneumoniae were serotyped and those of haemophilus species were typed by antibiograms along with other supporting methods. sera collected before or at the time of an exacerbation and ...	1978	25664
bacteriological findings in the transtracheal aspirate from patients with acute exacerbation of chronic bronchitis.	transtracheal aspirates from 87 patients with acute exacerbations of chronic bronchitis who had received no recent antibiotic treatment were examined. a single bacterial species was found in 83% of positive cultures. predominant pathogens were haemophilus influenzae and streptococcus pneumoniae which occurred jointly or separately in 50% of positive cultures. bacteria traditionally considered as non-pathogenic for the lower respiratory tract also appeared to play an aetiological role. enterobact ...	1978	25845
an adenosine 3':5'-monophosphate-adenosine binding protein from mouse liver. factors affecting the activation of the binding protein by adenosine 5'-triphosphate.		1978	23726
effects of bromocriptine on adenylate cyclase and phosphodiesterase activities of rat striatum.	the activity of 2-bromo-alpha-ergokryptine (bromocriptine) (5 mg kg-1, i.p.) on adenylate cyclase and on phosphodiesterase (pde-pde ii) of rat striatum, has been examined both in vitro and in vivo. in vitro and in vivo bromocriptine stimulated adenylate cyclase activity, but reduced the stimulating effect of dopamine on adenylate cyclase activity. bromocriptine showed a dose-dependent biphasic action on phosphodiesterases in vitro while in vivo it stimulated them. the results obtained proved bro ...	1978	24111
effects of stimulants, anorectics, and related drugs on schedule-controlled behavior.		1978	24228
active groups of extracellular endo-d-galacturonanase of aspergillus niger derived from ph effect on kinetic data.	in an attempt to characterize the groups essential for the catalytic action extracellular endo-d-galacturonanase of aspergillus niger (poly (1,4-alpha-d-galacturonide) glycanohydrolase, ec 3.2.1.15) the behaviour of the kinetic parameters as a function of ph was examined. the dependence of kcat and kcat/km on ph suggests that two dissociable groups are involved, for which the pk values of about 3.0 and 5.0 in the free enzyme and 3.06 and 5.72 in the catalytic complex were found at 30 degrees c. ...	1978	24473
neurogenic vasodilation of cat cerebral arteries.	transmural nerve stimulation (tns) with 0.3-msec pulses between 1 and 25 hz dilated cat cerebral artery segments in the presence of active muscle tone. maximum vasodilatation occurred at 8 hz. the dilator response to exogenous acetylcholine, but not to tns, was abolished by atropine. neither physostigmine nor hemicholinium affected the dilator response to tns, which persisted after administration of guanethidine, phenoxybenzamine, propranolol, reserpine, and chronic sympathectomy. however, it wa ...	1978	24505
prospects for the prevention of bacterial meningitis with polysaccharide vaccines.	most suppurative infections of the meninges are caused by five bacterial species: escherichia coli, haemophilus influenzae type b, streptococcus pneumoniae, neisseria meningitidis, and group b streptococcus. the immune response of adults to pneumococcal capsular polysaccharides has been studied in great detail and their responses to meningococcal and h. influenzae type b capsular polysaccharides are quite similar. immune responses of adults to e. coli and group b streptococcal antigens are disap ...	1978	31985
twice daily dosage of bacampicillin in chronic bronchitis. a double-blind study.	three groups of patients (total 48) with acute exacerbations of chronic bronchitis were treated orally for 10 days, in a double-blind clinical trial, with bacampicillin (an ampicillin ester) 1600 mg twice daily, 800 mg three times daily and oral ampicillin 1000 mg three times daily. most exacerbations were caused by haemophilus influenzae or streptococcus pneumoniae. clinical and bacteriological results were significantly more favourable in the two bacampicillin-treated groups. both drugs were g ...	1978	32615
purification and properties of a new restriction endonuclease from haemophilus influenzae rf.	haemophilus influenzae rf 232, showing the phenomena of restriction and modification, contains an endonuclease that inactivates in vitro the biological activity of dnas lacking the strain-specific modification. this specific restriction endonuclease has been purified to near homogeneity by a procedure that includes dna-agarose chromatography. this highly purified enzyme requires atp and mg2+ for activity and is stimulated by s-adenosylmethionine. the enzyme seems to cleave dna at well-defined si ...	1978	33045
studies on the structure-activity relationship of adrenergic beta-mimetic benzylamine derivatives. iv.1) aryl-substituted 1-aminotetralins and 1-aminoindans.		1978	34486
[treatment of bacterial meningitis with cefamandole].		1978	35821
response of lipogenic enzymes to overfeeding in liver and adipose tissue of light and heavy breeds of chicks.		1978	23141
comparative digestibility of acid detergent fiber by laboratory albino and wild polynesian rats.	the effects of adding 5%, 10%, and 15% acid detergent fiber to a nonfibrous basal diet were examined in a comparative feeding study with polynesian rats (rattus exulans) and laboratory rats. digestibility coefficients for dry matter, crude protein, and gross energy declined significantly in both species as fiber content increased, but averaged significantly lower in the polynesian than in the laboratory rat. fiber digestibility was not significantly affected by fiber level but was by species, wi ...	1978	23419
meningitis: the influence of routine otolaryngologic consultation on morbidity and mortality in 290 cases.	a prospective study was designed to obtain data on all meningitis patients admitted to a large county communicable disease unit. the epidemiologic and clinical features of 290 cases were analyzed to ascertain the effect of routine o.r.l. consultation on the morbidity and mortality of this disease. the results of physical examination provided current statistics as to the existence of ear, nose, and throat diseases associated with meningitis.	1978	23470
aerobic and anaerobic bacteriology of acute otitis media in children.	tympanocentesis and aerobic and anaerobic cultivation of the middle-ear fluid obtained was performed through one or both tympanic membranes of 62 children with acute otitis media. aerobic bacteria alone, predominantely pneumococcus and hemophilus influenzae, were isolated from 57% of patients; anaerobic organisms alone, most commonly propionibacterium acnes and peptococcus, from 15%. thirteen percent yielded mixtures of aerobes and anaerobes, and several had multiple aerobic or anaerobic agents. ...	1978	22590
a case of listeriosis in pregnancy with fetal survival.	listeriosis during pregnancy is generally considered to result in an intrauterine infection which affects the fetus before birth or in the perinatal period. a case of listeriosis in a 38-yr-old diabetic woman with an influenza-like disease in her 32nd wk of pregnancy is presented. two successive blood cultures were positive for listeria monocytogenes type 4b and her serum showed a rising titer for agglutinins to this organism. after antibiotic treatment of the patient she gave birth to a healthy ...	1978	264070
[retro-equatorial muscle plication. modified surgical technic with cüppers' suture].		1978	352561
b lymphocyte differentiation in lethally irradiated and reconstituted mice. a histological study using immunofluorescent detection of b lymphocytes.	the recovery of the b lymphocyte compartments was investigated in lethally irradiated mice reconstituted with fetal liver cells. this was done by means of immunofluorescence on frozen sections of spleen, lymph nodes and peyer's patches. the first b lymphocyte recovery in the spleen was observed on day 8, a few days earlier than in lymph nodes and peyer's patches (day 13). these early b cells in the spleen were found in the central part of the periarteriolar lymphatic sheath (pals). later on, whi ...	1978	352529
[use of visken-15 for treating hypertension].	the hypotensive effect of visken-15, a blocking agent of the beta-adrenergic receptors, was studied in 7 patients with stage ib hypertensive disease, in 18 with stage iia, and in 8 patients with stage iib under conditions of in- and out-patient establishments. a favourable effect was produced in 81.5% of patients who were given one tablet of the drug once or twice a day. treatment with visken-15 led to a decrease in systolic, diastolic and mean arterial pressure, in the rate of cardiac contracti ...	1978	372668
normal cardiac function with a hybrid heart.	a left ventricular bypass procedure using a cardiac allograft was performed in a patient with a long history of rheumatic heart disease and two aortic valve replacements. normal cardiac function was reestablished, and the only problem following transplantation was that of serious arrhythmias involving the recipient heart. eighteen months after left ventricular bypass bacterial endocarditis which was resistant to medical treatment developed on the aortic prosthesis. the patient underwent operatio ...	1978	352288
interactions of liposomes with mammalian cells.	in this review we have attempted to highlight each of the major areas of interest in liposome-cell interactions: the purely physical chemical, the cell biological, and the medical. liposomes can be generated in a number of ways and are classified as small unilamellar, large unilamellar, and multilamellar vesicles. although liposomes are easy to prepare, it is important to consider the effects of impurities, and also the possible changes in liposome properties with time (particularly at or below ...	1978	352245
[our experience with the estimation of lh-rh in female serum (author's transl)].		1978	352545
[february 1948 and the development of pharmacology on czechoslovakia].		1978	352542
[the pam program for the early detection of breast cancer: the initial results (1987-1990). programa de detección precoz de alteraciones mamarias].	we report the results of the pam program for the early detection of breast cancer, carried out in barcelona in females aged 50-70 years who were invited to participate by two personal letters. out of 5435 invited females in the three years of the program, 37.2% responded to the first cycle and 70.8% to the second. the rate of detection of cancer was 6.9/1000 participating women in the first cycle. the validity of mammography was high, comparable to that from other countries. sensitivity was 87.5 ...	1978	2041385
black, middle-class women in san antonio, texas.	fifty-six african-american women between the ages of 20 and 84 who had completed a minimum of 4 years of college and were employed in professional positions (eg, teacher, technician, lawyer, and physician) were identified in san antonio, texas. specific information concerning marital status, income, home ownership, family of origin, presence of professional siblings, husbands' characteristics, medical and psychiatric health, and significant influences in their lives were obtained by a semistruct ...	1978	1608061
[examination of trace element concentration in the myometrium of pregnant women].		1978	422062
adverse event monitoring in clinical trials of felodipine and omeprazole.	although most clinical trials encompass aspects of safety, methods for assessing the safety of a drug by recording adverse events have been poorly studied. it has been suggested that adverse events rather than adverse drug reactions should be monitored, since a reliable determination of which events were caused by the drug and which were not is only possible after analysing data from a substantial number of clinical trials. in the present study adverse events were monitored to see the extent to ...	1978	1606998
[hygienic aspects of the prevention of cardiovascular pathology].		1978	422038
screening for job placement: an in-house placement screening programme.	a system of screening for all types of job placement has recently been introduced at british airways, following consultation with all interested parties. the rationale, development and practical aspects are described.	1978	1606308
evidence for a nonpituitary source of amniotic fluid prolactin.	prolactin levels were determined during a gonadotropin-induced pregnancy following hypophysectomy for a chromophobe adenoma. maternal plasma prolactin concentrations did not vary significantly from prepregnancy values throughout gestation, remaining between 25 and 35 ng/ml. fetal prolactin levels were 55 ng/ml and maternal levels were 29 ng/ml at delivery. amniotic fluid prolactin concentration was approximately 100 ng/ml. decidual tissue isolated from the maternal surface of the chorion release ...	1978	421916
a double-blind comparison of morphine and buprenorphine in the prevention of pain after operation.	a double-blind, between-patient comparison has been made of the effects of morphine 10 mg i.v. and buprenorphine 0.3 mg i.v. on the prevention of pain after operation. the drugs were given by the anaesthetist at the end of the operation, and the onset and severity of pain were assessed by a trained nurse. both drugs caused a significant delay in the appearance of severe pain when compared with the control group, but with buprenorphine the mean delay of 10.5 h was more than twice that of morphine ...	1978	352372
[dentistry in the past, present and future].		1978	352369
effects of cue-controlled relaxation on psychomotor seizures: an experimental analysis.		1978	352332
brefeldin a-induced increase of sphingomyelin synthesis. assay for the action of the antibiotic in mammalian cells.	brefeldin a leads to an increase of sphingomyelin in chinese hamster ovary cells. the antibiotic is known to cause a dramatic morphological change of the endomembrane system in various mammalian cells resulting in a redistribution of golgi resident proteins to the endoplasmic reticulum (lippincott-schwartz, j., donaldson, j. g., schweizer, a., berger, e. g., hauri, h. p., yuan, l. c., and klausner, r. d. (1990) cell 60, 821-836). a strict correlation was found between the brefeldin a-induced inc ...	1978	1544889
[clinical symptomatology and systematization of esophagospasm].		1978	1145278
virus envelopes and plasma membranes.	in this review i have tried to describe the progress that has been made in studies of viral envelopes in the last few years. in every particular of structure, biogenesis, and assembly, increased knowledge has increased the apparent similarity between viral envelopes and plasma membranes. thus, the viral envelopes provide unique experimental opportunities for investigating membranes. we can expect that progress in our understanding of membrane structure will continue through the study of viral en ...	1978	352238
phase ii trial of pyrazofurin in patients with multiple myeloma refractory to standard cytotoxic therapy.		1978	476714
[results of antiestrogen therapy in metastasizing breast cancer].		1978	414048
[laboratory technics for the rapid diagnosis of viral infections: memorandum].		1978	352566