Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| comparison of the effect of vaginal zataria multiflora cream and oral metronidazole pill on results of treatments for vaginal infections including trichomoniasis and bacterial vaginosis in women of reproductive age. | effect of zataria multiflora on bacterial vaginosis and trichomonas vaginalis is shown in vivo and in vitro. we compare the effectiveness of zataria multiflora cream and oral metronidazole pill on results of treatment for vaginal infections including trichomonas and bacterial vaginosis; these infections occur simultaneously. the study included 420 women with bacterial vaginosis, trichomonas vaginalis, or both infections together, who were randomly divided into six groups. criteria for diagnosis ... | 2015 | 26266260 |
| medical devices; immunology and microbiology devices; classification of trichomonas vaginalis nucleic acid assay. final order. | the food and drug administration (fda) is classifying a trichomonas vaginalis nucleic acid assay into class ii (special controls). the agency is classifying the device into class ii (special controls) in order to provide a reasonable assurance of safety and effectiveness of the device. | 2015 | 26241999 |
| effect of verbascum thapsus ethanol extract on induction of apoptosis in trichomonas vaginalis in vitro. | trichomoniasis is a sexually transmitted disease (std) caused by a tiny parasite called trichomonas vaginalis. metronidazole is used as routine treatment of disease. some reports have confirmed the potential carcinogenic and teratogenic effects of this drug on fetus and indication of drug resistance. verbascum thapsus belongs to the family of scorphulariaceae. its antiinflammatory properties, disinfectant and skin healing effects are well known. this plant has been used to treat diarrhea and gen ... | 2015 | 26239850 |
| persistence of trichomonas vaginalis serostatus in men over time. | previous epidemiologic studies have observed positive associations between trichomonas vaginalis (tv) serostatus and both prostate cancer (pca) risk and mortality. however, only a few small older studies have examined tv antibody persistence over time, all of which were composed mainly of female patients. therefore, we examined tv antibody persistence over time, as well as intra-individual variability, among middle- to older-aged men in the southern community cohort study (sccs). | 2015 | 26223890 |
| nitric oxide maintains cell survival of trichomonas vaginalis upon iron depletion. | iron plays a pivotal role in the pathogenesis of trichomonas vaginalis, the causative agent of highly prevalent human trichomoniasis. t. vaginalis resides in the vaginal region, where the iron concentration is constantly changing. hence, t. vaginalis must adapt to variations in iron availability to establish and maintain an infection. the free radical signaling molecules reactive oxygen species (ros) and reactive nitrogen species (rns) have been proven to participate in iron deficiency in eukary ... | 2015 | 26205151 |
| [possibility for luminescence identification of different trichomonas vaginalis forms]. | the paper presents the results of examining the morphology of different forms of trichomonas vaginalis by indirect immunofluorescence. fluorescence microscopy revealed that the typical forms of vaginal trichomonads showed a very bright light green glow, around the periphery of a cell in particular; the atypical forms of trichomonads emitted in the green spectral region less brilliantly and evenly. trichomonas fluorescence intensity was measured by spectrofluorescence assay. the experimental find ... | 2015 | 26152037 |
| prevalence of trichomonas vaginalis infection in symptomatic and asymptomatic women in central vietnam. | the diffusion of trichomoniasis in vietnam has been scarcely studied. the aim of this study was to investigate the prevalence of trichomoniasis in a group of symptomatic and asymptomatic women in central vietnam. relationships between education, socioeconomical and marital status, and sexual behavior with infection have also been investigated. | 2015 | 26142677 |
| synthetic sirnas effectively target cystein protease 12 and α-actinin transcripts in trichomonas vaginalis. | the flagellated protozoan trichomonas vaginalis (t. vaginalis) causes trichomoniasis, a reproductive tract infection, in humans. trichomoniasis is the most common non-viral sexually transmitted disease worldwide. in addition to direct consequences such as infertility and abortion, there are indications that trichomoniasis favours development of prostate cancer and it has also been associated with increased risk of spreading human immunodeficiency virus and papillomavirus infections. reports from ... | 2015 | 26134763 |
| cytomorphometric and morphological analysis in women with trichomonas vaginalis infection: micronucleus frequency in exfoliated cervical epithelial cells. | the aim of this study was to explore the cytomorphometric and morphological effects of trichomonas vaginalis in exfoliated epithelial cells. | 2015 | 26112451 |
| trypanocidal, trichomonacidal and cytotoxic components of cultivated artemisia absinthium linnaeus (asteraceae) essential oil. | artemisia absinthium is an aromatic and medicinal plant of ethnopharmacological interest and it has been widely studied. the use ofa. absinthium based on the collection of wild populations can result in variable compositions of the extracts and essential oils (eos). the aim of this paper is the identification of the active components of the vapour pressure (vp) eo from a selected and cultivated a. absinthium spanish population (t2-11) against two parasitic protozoa with different metabolic pathw ... | 2015 | 26107187 |
| p transposable elements in drosophila and other eukaryotic organisms. | p transposable elements were discovered in drosophila as the causative agents of a syndrome of genetic traits called hybrid dysgenesis. hybrid dysgenesis exhibits a unique pattern of maternal inheritance linked to the germline-specific small rna piwi-interacting (pirna) pathway. the use of p transposable elements as vectors for gene transfer and as genetic tools revolutionized the field of drosophila molecular genetics. p element transposons have served as a useful model to investigate mechanism ... | 2015 | 26104714 |
| genetic diversity of trichomonas vaginalis clinical isolates from henan province in central china. | trichomonas vaginalis is a flagellated protozoan parasite that infects the human urogenital tract, causing the most common non-viral, sexually transmitted disease worldwide. in this study, genetic variants of t. vaginalis were identified in henan province, china. fragments of the small subunit of nuclear ribosomal rna (18s rrna) were amplified from 32 t. vaginalis isolates obtained from seven regions of henan province. overall, 18 haplotypes were determined from the 18s rrna sequences. each samp ... | 2015 | 26103990 |
| trichomonas vaginalis cysteine proteinases: iron response in gene expression and proteolytic activity. | we focus on the iron response of trichomonas vaginalis to gene family products such as the cysteine proteinases (cps) involved in virulence properties. in particular, we examined the effect of iron on the gene expression regulation and function of cathepsin l-like and asparaginyl endopeptidase-like cps as virulence factors. we addressed some important aspects about cps genomic organization and we offer possible explanations to the fact that only few members of this large gene family are expresse ... | 2015 | 26090464 |
| t. vaginalis infection is associated with increased il-8 and tnfr1 levels but with the absence of cd38 and hladr activation in the cervix of esn. | trichomonas vaginalis infection is associated with an increased risk of hiv infection in exposed-seronegative women (esn) despite their unique immune quiescent profile. it is important to understand possible mechanisms, such as recruitment of activated t cells, by which t. vaginalis could facilitate hiv infection in this population. | 2015 | 26083468 |
| comparison between mixed lysate antigen and α-actinin antigen in elisa for serodiagnosis of trichomoniasis. | the aim of this study was to identify an antigen suitable for elisa for serodiagnosis of trichomonas vaginalis (t. vaginalis) infection. mixed lysate antigen (ag) from eight strains of t. vaginalis and recombinant α-actinin protein was compared. the sera of three groups were examined by elisa: 73 women infected with trichomoniasis served as a positive control, 31 male volunteers as a negative control, and 424 women attending an outpatient health screening at hanyang university guri hospital. bas ... | 2015 | 26072305 |
| population structure and genetic diversity of the parasite trichomonas vaginalis in bristol, uk. | the protozoan parasite trichomonas vaginalis is the causative agent of trichomoniasis, an extremely common, but non-life-threatening, sexually-transmitted disease throughout the world. recent population genetics studies of t. vaginalis have detected high genetic diversity and revealed a two-type population structure, associated with phenotypic differences in sensitivity to metronidazole, the drug commonly used for treatment, and presence of t. vaginalis virus. there is currently a lack of data o ... | 2015 | 26051885 |
| prevalence of trichomoniasis among women in kermanshah, iran. | trichomoniasis, caused by trichomonas vaginalis, is the most common sexually transmitted disease (std) in the world with estimates of 7-8 million infections annually in the united states and 180 million globally. | 2015 | 26019904 |
| synthesis and antiprotozoal activity of mono- and bis-uracil isatin conjugates against the human pathogen trichomonas vaginalis. | a library of mono- and bis-uracil isatin conjugates were synthesized and subjected for the assessment of their in vitro activity against the protozoal pathogen trichomonas vaginalis. the structure activity studies (sar) revealed that the bis-uracil-isatin based conjugates were more effective than their corresponding mono conjugates in inhibiting the growth of t. vaginalis at approximately 10 μm with no visual effect on mammalian cells at the same concentration. | 2015 | 25999204 |
| sequestration of host-cd59 as potential immune evasion strategy of trichomonas vaginalis. | trichomonas vaginalis is known to evade complement-mediated lysis. because the genome of t. vaginalis does not possess dna sequence with homology to human protectin (cd59), a complement lysis restricting factor, we tested the hypothesis that host cd59 acquisition by t. vaginalis organisms mediates resistance to complement killing. this hypothesis was based on the fact that trichomonads are known to associate with host proteins. no cd59 was detected on the surface of t. vaginalis grown in serum-b ... | 2015 | 25976413 |
| direct diagnosis of trichomonas vaginalis infection on archived pap smears using nested pcr. | little information is available concerning pcr-based direct detection of trichomonas infections on archived pap (papanicolaou)-stained smears. this study investigates dna extraction and amplification from archived pap smears. trichomonas vaginalis is a parasitic protozoan that infects the urogenital tract of women. | 2015 | 25633887 |
| protocols for the routine screening of drug sensitivity in the human parasite trichomonas vaginalis. | trichomonas vaginalis is a sexually transmitted protozoan parasite of humans. treatment of trichomoniasis is almost completely dependent on the old drug metronidazole and is hampered by resistance. new drug development, like routine screening for drug resistance, has however been hampered by the lack of reliable screening protocols with sufficient throughput. here we report on two separate in vitro protocols that use fluorescent dyes and allow for standardized drug sensitivity testing on the req ... | 2015 | 25618339 |
| dithiocarbamate-thiourea hybrids useful as vaginal microbicides also show reverse transcriptase inhibition: design, synthesis, docking and pharmacokinetic studies. | prophylactic prevention is considered as the most promising strategy to tackle sti/hiv. twenty-five dithiocarbamate-thiourea hybrids (14-38) were synthesized as woman controlled topical vaginal microbicides to counter trichomonas vaginalis and sperm along with rt inhibition potential. the four promising compounds (18, 26, 28 and 33) were tested for safety through cytotoxic assay against human cervical cell line (hela) and compatibility with vaginal flora, lactobacillus. docking study of most pro ... | 2015 | 25592712 |
| comparison of four diagnostic techniques for detection of trichomonas vaginalis infection in females attending tertiary care hospital of north india. | trichomonas vaginalis causes a common sexually transmitted disease trichomoniasis, which may lead to increased risk of transmission of human immunodeficiency virus infection and other pelvic inflammatory diseases. wet mount examination is the most common test for diagnosis, but it has low sensitivity. acridine orange staining can be used for diagnosis, but it requires special microscopic facility. culture is considered as the gold standard, but it takes a long time for diagnosis. osom trichomona ... | 2015 | 25673589 |
| involvement of pi3k/akt and mapk pathways for tnf-α production in siha cervical mucosal epithelial cells infected with trichomonas vaginalis. | trichomonas vaginalis; induces proinflammation in cervicovaginal mucosal epithelium. to investigate the signaling pathways in tnf-α production in cervical mucosal epithelium after t. vaginalis infection, the phosphorylation of pi3k/akt and mapk pathways were evaluated in t. vaginalis-infected siha cells in the presence and absence of specific inhibitors. t. vaginalis increased tnf-α production in siha cells, in a parasite burden-dependent and incubation time-dependent manner. in t. vaginalis-inf ... | 2015 | 26323834 |
| natural and synthetic compound anti-trichomonas vaginalis: an update review. | trichomonas vaginalis is a flagellate protozoan that causes trichomonosis, a sexually transmitted disease of worldwide importance. however, the infection has long received much less attention than other parasitic and sexually transmitted diseases. this negligence leads to poor diagnosis and underestimated prevalence values, and consequently, it has been associated to increasing acquisition and transmission of hiv, pregnancy outcomes, infertility, pelvic inflammatory disease, and cervical and pro ... | 2015 | 25786392 |
| prevalence of trichomonas vaginalis infection among egyptian women using culture and latex agglutination: cross-sectional study. | this is a cross-sectional study carried out in the obstetrics and gynecology department at kasr al- ainy cairo university hospitals. | 2015 | 25783642 |
| trichomonas vaginalis associated with chronic penile ulcers and multiple urethral fistulas. | the case of a 29-year-old, hiv-infected man presenting with trichomonas vaginalis (tv)-associated chronic penile ulcers and multiple urethral fistulas is described. to our knowledge, this is the first description of chronic tv infection being implicated as the probable cause of a destructive lesion leading to sinus drainage and fistula formation. | 2015 | 25778505 |
| synthesis and in vitro and in vivo biological evaluation of substituted nitroquinoxalin-2-ones and 2,3-diones as novel trichomonacidal agents. | two series of ten novel 7-nitroquinoxalin-2-ones and ten 6-nitroquinoxaline-2,3-diones with diverse substituents at positions 1 and 4 were synthesized and evaluated against the sexually transmitted parasite trichomonas vaginalis. furthermore, diverse molecular and drug-likeness properties were analyzed to predict the oral bioavailability following the lipinski's "rule of five". 7-nitroquinoxalin-2-one derivatives displayed moderate to high in vitro activity while the efficiency of most nitroquin ... | 2015 | 25771033 |
| trichomoniasis: a brief review of diagnostic methods and our experience with real-time pcr for detecting infection. | trichomoniasis is the most common non-viral sexually transmitted infection, and it is caused by the protozoan flagellate trichomonas vaginalis. although highly prevalent in sexually active women, it has long been overlooked in other groups of potentially infected people. recently, studies have shown that trichomoniasis increases the risk of infection with human immunodeficiency virus and can cause adverse outcomes of pregnancy, which has increased interest in t. vaginalis and increased the need ... | 2015 | 25770306 |
| trichomonas vaginalis infection among iranian general population of women: a systematic review and meta-analysis. | trichomonas vaginalis (t. vaginalis) is one of the main causes of vaginitis, prostatitis, and cervicitis all over the world. little information is available regarding the burden of t. vaginalis infection in iranian women. this systematic review and meta-analysis were carried out to determine the prevalence of t. vaginalis among general population of iranian women. data were systematically collected from 1992 to 2012 in iran on such electronic databases as pubmed, google scholar, science direct, ... | 2015 | 25732256 |
| the c-terminal tail of tetraspanin proteins regulates their intracellular distribution in the parasite trichomonas vaginalis. | the parasite trichomonas vaginalis is the causative agent of trichomoniasis, a prevalent sexually transmitted infection. here, we report the cellular analysis of t.vaginalis tetraspanin family (tvtsps). this family of membrane proteins has been implicated in cell adhesion, migration and proliferation in vertebrates. we found that the expression of several members of the family is up-regulated upon contact with vaginal ectocervical cells. we demonstrate that most tvtsps are localized on the surfa ... | 2015 | 25703821 |
| pentamycin shows high efficacy against trichomonas vaginalis. | trichomonas vaginalis is the causative agent of the venereal disease trichomoniasis, which is the most frequent non-viral sexually transmitted disease worldwide. since the 1960s, metronidazole has been the standard treatment, however an increasing number of cases with metronidazole-resistant strains is being reported. in this study, pentamycin, a polyene antibiotic, was tested for its in vitro efficacy against t. vaginalis using four strains with different metronidazole susceptibilities. it was ... | 2015 | 25703311 |
| experience of successful treatment of patients with metronidazole-resistant trichomonas vaginalis with zinc sulfate: a case series. | there are no universally successful guidelines for the treatment of metronidazole-resistant vaginal trichomoniasis. this is distressing for patients and frustrating for physicians. we therefore decided to evaluate whether zinc sulfate douche is effective in treating vaginal trichomoniasis, because the compound is a natural antimicrobial chemical defense in humans. | 2015 | 26522122 |
| detection and molecular characterization of double-stranded rna viruses in philippine trichomonas vaginalis isolates. | the flagellated protozoon trichomonas vaginalis that parasitizes the urogenital tract of humans was reported to harbor double-stranded rna (dsrna) viruses. these viruses, identified as trichomonas vaginalis virus (tvv), belong to the genus trichomonasvirus of the family totiviridae. four species, formally recognized by the international committee on taxonomy of viruses (ictv), have been reported and distinguished by pairwise comparisons of the sequences of genes coding for major capsid protein ( ... | 2015 | 26471924 |
| molecular typing of the actin gene of trichomonas vaginalis isolates by pcr-rflp in iran. | trichomonas vaginalis is a human urogenital pathogen that causes trichomoniasis, the most common nonviral, parasitic sexually transmitted infection in the world. at present, little is known regarding the degree of strain variability of t. vaginalis. a classification method for t. vaginalis strains would be a useful tool in the study of the epidemiology, drug resistance, pathogenesis and transmission of t. vaginalis. eight different types of actin genes have been identified by pcr-rflp in t. vagi ... | 2015 | 26542260 |
| activation of mapk is required for ros generation and exocytosis in hmc-1 cells induced by trichomonas vaginalis-derived secretory products. | trichomonas vaginalis is a flagellated protozoan parasite that causes vaginitis and cervicitis in women and asymptomatic urethritis and prostatitis in men. mast cells have been reported to be predominant in vaginal smears and vaginal walls of patients infected with t. vaginalis. mitogen-activated protein kinase (mapk), activated by various stimuli, have been shown to regulate the transcriptional activity of various cytokine genes in mast cells. in this study, we investigated whether mapk is invo ... | 2015 | 26537039 |
| digestion of glycogen by a glucosidase released by trichomonas vaginalis. | trichomonas vaginalis is a protozoan parasite that is the causative agent of trichomoniasis, a widespread sexually transmitted disease. in vitro culture of t. vaginalis typically employs a medium supplemented with either maltose or glucose and carbohydrates are considered essential for growth. although the nature of the carbohydrates utilized by t. vaginalis in vivo is undefined, the vaginal epithelium is rich in glycogen, which appears to provide a source of carbon for the vaginal microbiota. h ... | 2015 | 26420465 |
| optimal reference genes for gene expression normalization in trichomonas vaginalis. | trichomonas vaginalis is the etiologic agent of trichomonosis, the most common non-viral sexually transmitted disease worldwide. this infection is associated with several health consequences, including cervical and prostate cancers and hiv acquisition. gene expression analysis has been facilitated because of available genome sequences and large-scale transcriptomes in t. vaginalis, particularly using quantitative real-time polymerase chain reaction (qrt-pcr), one of the most used methods for mol ... | 2015 | 26393928 |
| in vitro anti-trichomonas vaginalis activity of pistacia lentiscus mastic and ocimum basilicum essential oil. | trichomonas vaginalis is a protozoan parasite that causes trichomoniasis; a cosmopolitan sexually transmitted disease. metronidazole is the drug of choice for t. vaginalis infections. the increase in metronidazole resistant parasites and undesirable side effects of this drug makes the search for an alternative a priority for the management of trichomoniasis. pistacia lentiscus mastic and ocimum basilicum oil are known for their antibacterial, antifungal, antiviral and antiprotozoal effects. the ... | 2015 | 26345053 |
| iron from haemoglobin and haemin modulates nucleotide hydrolysis in trichomonas vaginalis. | extracellular atp may act as a danger signalling molecule, inducing inflammation and immune responses in infection sites. the ectonucleotidases ntpdase and ecto-5'-nucleotidase are enzymes that modulate extracellular nucleotide levels; these enzymes have been previously characterised in trichomonas vaginalis. iron plays an important role in the complex trichomonal pathogenesis. herein, the effects of iron on growth, nucleotide hydrolysis and ntpdase gene expression in t. vaginalis isolates from ... | 2015 | 25946243 |
| antenatal lower genital tract infection screening and treatment programs for preventing preterm delivery. | genital tract infection is associated with preterm birth (before 37 weeks' gestation). screening for infections during pregnancy may therefore reduce the numbers of babies being born prematurely. however, screening for infections may have some adverse effects, such as increased antibiotic drug resistance and increased cost of treatment. | 2015 | 25922860 |
| the pathogenesis of human cervical epithelium cells induced by interacting with trichomonas vaginalis. | trichomonas vaginalis is a protozoan parasite that occurs in the urogenital-vaginal tract and is the primary causative agent of trichomoniasis, a common sexually transmitted disease in humans. the aggregation of this protozoan tends to destroy epithelial cells and induce pathogenesis. | 2015 | 25901354 |
| papanicolaou smear findings in solid-organ transplant recipients compared with normal subjects according to the bethesda 2001 system. | solid-organ transplant recipients are at increased risk of developing cancer including cervical cancer compared with woman in the general population, mostly due to long-term immunosuppressive therapy. the papanicolaou smear remains the primary method of screening cervical pathology including preinvasive and invasive lesions. the objective of this study was to evaluate pap smear findings in solid-organ transplant recipients, determine the prevalence of abnormal smears, and compare these patients ... | 2015 | 25894158 |
| p transposable elements in drosophila and other eukaryotic organisms. | p transposable elements were discovered in drosophila as the causative agents of a syndrome of genetic traits called hybrid dysgenesis. hybrid dysgenesis exhibits a unique pattern of maternal inheritance linked to the germline-specific small rna piwi-interacting (pirna) pathway. the use of p transposable elements as vectors for gene transfer and as genetic tools revolutionized the field of drosophila molecular genetics. p element transposons have served as a useful model to investigate mechanism ... | 2015 | 25893144 |
| kinetics of circulating antibody response to trichomonas vaginalis: clinical and diagnostic implications. | persistence of antibodies against pathogens after antimicrobial treatment is a marker of therapy failure or evolution to a chronic infection. the kinetics of antibody production decrease following antigen elimination is highly variable, and predicting the duration of soluble immunity in infectious diseases is often impossible. this hampers the development and use of immunoassays for diagnostic and seroepidemiological purposes. in the case of trichomonas vaginalis infection, the kinetics of antib ... | 2015 | 25887282 |
| successful treatment of refractory trichomonas vaginalis infection using intravenous metronidazole. | trichomonas vaginalis is a sexually transmitted protozoan infection resulting in a vulvo-vaginitis and altered vaginal discharge in symptomatic women. since its introduction in the 1960 s, metronidazole has been the first-line drug for trichomonal infection. other nitroimidazoles, such as tinidazole, are used as alternative regimens with similar activity but at a greater expense. treatment failure usually represents patient non-compliance or reinfection, although metronidazole resistance has pre ... | 2015 | 25161176 |
| gene-expression analysis of cold-stress response in the sexually transmitted protist trichomonas vaginalis. | trichomonas vaginalis is the etiologic agent of trichomoniasis, the most common nonviral sexually transmitted disease in the world. this infection affects millions of individuals worldwide annually. although direct sexual contact is the most common mode of transmission, increasing evidence indicates that t. vaginalis can survive in the external environment and can be transmitted by contaminated utensils. we found that the growth of t. vaginalis under cold conditions is greatly inhibited, but rec ... | 2015 | 25440978 |
| trichomonas vaginalis origins, molecular pathobiology and clinical considerations. | to integrate a selection of the most recent data on trichomonas vaginalis origins, molecular cell biology and t. vaginalis interactions with the urogenital tract microbiota with trichomoniasis symptoms and clinical management. | 2015 | 25485651 |
| the recombinant prepro region of tvcp4 is an inhibitor of cathepsin l-like cysteine proteinases of trichomonas vaginalis that inhibits trichomonal haemolysis. | trichomonas vaginalis expresses multiple proteinases, mainly of the cysteine type (cps). a cathepsin l-like 34kda cp, designated tvcp4, is synthesized as a 305-amino-acid precursor protein. tvcp4 contains the prepro fragment and the catalytic triad that is typical of the papain-like cp family of clan ca. the aim of this work was to determine the function of the recombinant tvcp4 prepro region (pptvcp4r) as a specific inhibitor of cps. we cloned, expressed, and purified the recombinant tvcp4 prep ... | 2015 | 25499446 |
| epidemiology and laboratory characteristics of trichomonas vaginalis infection in croatian men with and without urethritis syndrome: a case-control study. | the main objective of this study is to determine the prevalence of trichomoniasis in men with and without symptoms of urethritis, with concomitant analysis of sociodemographic and behavioural specificities of both groups. also, the objective is to evaluate laboratory methods used in the diagnostics of this parasitic disease. | 2015 | 25568091 |
| emphysematous vaginitis. | emphysematous vaginitis is a rare condition, characterized by the presence of multiple gas-filled cysts in the vaginal and/or exocervical mucosa. although its etiology is not completely understood, it is self-limited, with a benign clinical course. vaginal discharge, sometimes bloody, and pruritus are the most common symptoms. chronic and acute inflammation can be found, and diseases that impair the immune system and pregnancy have been associated with this condition. | 2015 | 25551590 |
| modulation of dendritic cell function by trichomonas vaginalis-derived secretory products. | trichomoniasis caused by the parasitic protozoan trichomonas vaginalis is the most common sexually transmitted disease in the world. dendritic cells are antigen presenting cells that initiate immune responses by directing the activation and differentiation of naïve t cells. in this study, we analyzed the effect of trichomonas vaginalis-derived secretory products on the differentiation and function of dendritic cells. differentiation of bone marrow-derived dendritic cells in the presence of t. va ... | 2015 | 24965578 |
| trichomonas vaginalis infections are rare among young patients attending an sti clinic in sweden. | 2015 | 25137630 | |
| drug-free chitosan coated poly(isobutylcyanoacrylate) nanoparticles are active against trichomonas vaginalis and non-toxic towards pig vaginal mucosa. | the present work reports a non-conventional therapeutic strategy based on the use of vaginally-applied formulations for the treatment of trichomoniasis due to trichomonas vaginalis without adding a drug. | 2015 | 25319099 |
| microscopy outperformed in a comparison of five methods for detecting trichomonas vaginalis in symptomatic women. | in the uk, despite its low sensitivity, wet mount microscopy is often the only method of detecting trichomonas vaginalis infection. a study was conducted in symptomatic women to compare the performance of five methods for detecting t. vaginalis: an in-house polymerase chain reaction (pcr); aptima t. vaginalis kit; osom ®trichomonas rapid test; culture and microscopy. symptomatic women underwent routine testing; microscopy and further swabs were taken for molecular testing, osom and culture. a tr ... | 2015 | 24855131 |
| prevalence of trichomonas vaginalis, mycoplasma genitalium and ureaplasma urealyticum in men with urethritis attending an urban sexual health clinic. | we conducted a study to determine the prevalence of trichomonas vaginalis (tv), mycoplasma genitalium (mg) and ureaplasma urealyticum (uu) in men with urethritis, attending an urban sexual health clinic, in order to inform screening and treatment policies. men attending an urban sexual health clinic between june 2011 and january 2012 were evaluated. urine samples were collected from men with urethritis and tested for chlamydia trachomatis (ct), neisseria gonorrhoeae (gc) and tv using transcripti ... | 2015 | 24925897 |
| prevalence and risk factors for chlamydia trachomatis, neisseria gonorrhoeae and trichomonas vaginalis infection in pregnant women in papua new guinea. | to determine the prevalence of, and risk factors associated with, chlamydia trachomatis, neisseria gonorrhoeae and trichomonas vaginalis infection in pregnant women in madang, papua new guinea (png). | 2015 | 25313204 |
| prevalence of trichomonas vaginalis, chlamydia trachomatis, neisseria gonorrhoeae and human papillomavirus in a sexual health clinic setting in urban sri lanka. | the prevalences of trichomonas vaginalis, chlamydia trachomatis, neisseria gonorrhoeae, and human papillomavirus (hpv) in sri lanka are not well reported; the objective of this study is to describe the prevalences of these four sexually transmitted infections among attendees of sexual health clinic in an urban setting. vaginal swabs were collected from consenting women attending a sexual health clinic and tested for the presence of the above sexually transmitted infections using nucleic acid amp ... | 2015 | 25258396 |
| epidemiology of sexually transmitted infections in rural haitian men. | the study attempts to determine the prevalence of organisms associated with urethritis in men in rural southwestern haiti and to determine the association with demographic, clinical and laboratory variables. a standardised verbal interview was conducted; genital examinations were done; urethral swabs were collected for nucleic acid amplification testing, and first void urine was obtained for urinalysis. the mean participant age was 54; 88.8% lived in a rural area. swabs were positive for trichom ... | 2015 | 25228665 |
| a mixed methods approach to assess the likelihood of testing for sti using self-collected samples among behaviourally bisexual women. | behaviourally bisexual women (women who have sex with women and men (wswm)) are more likely to report a history of sexually transmitted infections (sti) than women who have sex exclusively with men or exclusively with women. barriers to care may prohibit wswm from seeking sti testing. the present study investigated participant willingness to self-collect oral, vaginal and anal samples for sti testing. | 2015 | 25637328 |
| a multiplex pcr assay for the simultaneous detection of chlamydia trachomatis, neisseria gonorrhoeae, and trichomonas vaginalis. | for developing countries, sexually transmitted infections (stis) and their complications are ranked in the top 5 disease categories for which adults seek medical treatment. chlamydia trachomatis (ct), neisseria gonorrhoeae (ng), and trichomonas vaginalis (tv) are the three most common stis worldwide, with tv accounting for over half of the cases. in developing countries, traditional methods for diagnosing stis are laborious, often not very sensitive, and have a long turnaround time with most rec ... | 2015 | 25595915 |
| comparison of cervico-vaginal colonization among sexually active women by intrauterine device use. | in this study we aimed to evaluate the effect of intrauterine devices (iuds) on cervico-vaginal colonization. | 2015 | 26409733 |
| evaluation of the new amplisens multiplex real-time pcr assay for simultaneous detection of neisseria gonorrhoeae, chlamydia trachomatis, mycoplasma genitalium, and trichomonas vaginalis. | in this study, we performed an evaluation of the new ce-marked multiplex real-time amplisens n.gonorrhoeae/c.trachomatis/m.genitalium/t.vaginalis-multiprime-frt pcr assay compared to aptima tests, i.e., aptima combo 2 assay, aptima trichomonas vaginalis assay (fda-approved), and two different aptima mycoplasma genitalium assays (research use only; one of them only used for discrepancy analysis). vaginal swabs (n = 209) and first-void urine (fvu) specimens from females (n = 498) and males (n = 55 ... | 2015 | 26299582 |
| prevalence of vulvovaginitis and relation to physical findings in girls assessed for suspected child sexual abuse. | the presence of sexually transmitted infections (stis) in patients with suspected sexual abuse is uncommon in the field of pediatrics. | 2015 | 26294142 |
| distribution of human papillomavirus (hpv) genotypes and bacterial vaginosis presence in cervical samples from paraguayan indigenous. | to determine the frequency of human papillomavirus (hpv) types and to assess bacterial vaginosis (bv) possible associations with cervical infections in indigenous paraguayan women of the department of presidente hayes. | 2015 | 26283550 |
| diagnosis and treatment of bacterial prostatitis. | prostate inflammation is a common syndrome, especially in men under 50. it usually presents with voiding symptoms and pain in the genitourinary area, and sometimes as sexual dysfunction. based on clinical and laboratory characteristics, prostatitis is classified as acute bacterial prostatitis, chronic bacterial prostatitis, chronic inflammatory and non-inflammatory prostatitis or chronic pelvic pain syndrome, and asymptomatic inflammatory prostatitis. bacterial prostatitis is most often caused b ... | 2015 | 26086164 |
| the role of chlamydia trachomatis in high-risk human papillomavirus persistence among female sex workers in nairobi, kenya. | little is known about risk factors for persistent high-risk human papillomavirus (hrhpv) infection in low-income settings, and prior research has not quantified the relative duration of hrhpv infections stratified by risk factors. we compared the duration of hrhpv infection among female sex workers (fsws) by exposure to sexually transmitted infections (stis), using a highly sensitive biomarker assay. | 2015 | 25970306 |
| detection of mycoplasma genitalium from male primary urine specimens: an epidemiologic dichotomy with trichomonas vaginalis. | a total of 2750 male urines subjected to a transcription-mediated amplification (tma)-based mycoplasma genitalium assay yielded 188 positive results (6.84%). this rate was similar to chlamydia trachomatis (6.87%; p = 0.96) and greater than neisseria gonorrhoeae (4.0%) and trichomonas vaginalis (2.3%; p < 0.0002). mean age of m. genitalium-infected males (30.8) was similar to n. gonorrhoeae (p = 0.78) but less than t. vaginalis (mean, 41.6; p < 0.0001). a total of 266 sti clinic encounters had at ... | 2015 | 25934156 |
| prevalence and factors associated with sexually transmitted infections among hiv positive women opting for intrauterine contraception. | women living with hiv/aids (wlha) are a high risk group for sexually transmitted infections (stis). however, the majority of women with stis are asymptomatic. data on prevalence of stis among wlha in uganda are limited. the objective of the study was to determine prevalence and factors associated with stis among wlha opting for intrauterine contraceptive device (iud). | 2015 | 25859659 |
| opportunities and pitfalls of molecular testing for detecting sexually transmitted pathogens. | in the last 20 years, nucleic acid amplification tests (naats) have gradually replaced traditional methods for the detection of sexually transmitted infections. naat technology comes with some considerable benefits for diagnosis, including increased sensitivity, rapid result turnaround and suitability for high throughput screening of asymptomatic individuals using more-readily available specimens. however, the transition to naat has not come without its problems. false-negative and false-positiv ... | 2015 | 25714587 |
| analytical performance of multiplex real-time pcr for six sexually transmitted pathogens. | most organisms that cause sexual transmitted diseases (stds) are fastidious pathogens that are difficult to detect with conventional microbiological methods and the proportions of multiple infections were noted up to 39.3% among the sti-positive subjects. however, only a few multiplex pcr and multiplex real-time pcr tests that can screen more than six microorganisms that cause stds have been assessed. | 2015 | 26732001 |
| sexual assault and sexually transmitted infections in adults, adolescents, and children. | survivors of sexual assault are at risk for acquiring sexually transmitted infections (stis). we conducted literature reviews and invited experts to assist in updating the sexual assault section for the 2015 centers for disease control and prevention sexually transmitted diseases (std) treatment guidelines. new recommendations for sti management among adult and adolescent sexual assault survivors include use of nucleic acid amplification tests (naats) for detection of trichomonas vaginalis by va ... | 2015 | 26602623 |
| advances in the understanding and treatment of male urethritis. | neisseria gonorrhoeae and chlamydia trachomatis are well-documented urethral pathogens, and the literature supporting mycoplasma genitalium as an etiology of urethritis is growing. trichomonas vaginalis and viral pathogens (herpes simplex virus types 1 and 2 and adenovirus) can cause urethritis, particularly in specific subpopulations. new data are emerging regarding the potential role of bacterial vaginosis-associated bacteria in urethritis, although results are inconsistent regarding the patho ... | 2015 | 26602615 |
| performance evaluation of a dna chip assay in the identification of major genitourinary pathogens. | to prevent the recurrence of genitourinary infections and to reduce the risks of their complications, accurate and rapid diagnosis are required. stdetect® chip is a dna chip which allows for the simultaneous detection of 13 major genitourinary pathogens in a single vaginal swab or urine specimen. we evaluated the analytical performance of the stdetect® chip for detecting target pathogens that commonly cause genitourinary infections. | 2015 | 25533217 |
| sexually transmitted pathogens, depression, and other manifestations associated with premenstrual syndrome. | this study investigated whether sexually transmitted infections and lifestyle variables are associated with premenstrual syndrome (pms) as well as particular manifestations commonly associated with pms. data were gathered from medical records of 500 regularly cycling women. the following infectious agents were investigated: human papillomavirus, chlamydia trachomatis, neisseria gonorrheae, gardnerella vaginalis, candida albicans, and trichomonas vaginalis. bivariate tests and multivariate logist ... | 2015 | 26272230 |
| value of bacterial culture of vaginal swabs in diagnosis of vaginal infections. | vaginal and cervical swab culture is still very common procedure in our country's everyday practice whereas simple and rapid diagnostic methods have been very rarely used. the aim of this study was to show that the employment of simple and rapid diagnostic tools [vaginal fluid wet mount microscopy (vfwmm), vaginal ph and potassium hydroxide (koh) test] offers better assessment of vaginal environment than standard microbiologic culture commonly used in serbia. | 2015 | 26226725 |
| genome mining offers a new starting point for parasitology research. | parasites including helminthes, protozoa, and medical arthropod vectors are a major cause of global infectious diseases, affecting one-sixth of the world's population, which are responsible for enormous levels of morbidity and mortality important and remain impediments to economic development especially in tropical countries. prevalent drug resistance, lack of highly effective and practical vaccines, as well as specific and sensitive diagnostic markers are proving to be challenging problems in p ... | 2015 | 25563615 |
| mucosal blood group antigen expression profiles and hiv infections: a study among female sex workers in kenya. | the abo blood group antigens are carbohydrate moieties expressed on human red blood cells however; these antigens can also be expressed on some other cells particularly the surface of epithelial cells and may be found in mucosal secretions. in many human populations 80% secrete abo antigens (termed 'secretors') while 20% do not (termed 'non-secretors'). furthermore, there are disease conditions that are associated with secretor status. | 2015 | 26186209 |
| utility of microbiological profile of symptomatic vaginal discharge in rural women of reproductive age group. | symptomatic vaginal discharge is the most frequent symptom in women of reproductive age group. owing to social stigma majority of affected women hesitate to seek medical consultation. therefore the actual incidence of vaginal discharge is much more than what is reported. the aim of the study is to determine the microbiological profile of symptomatic vaginal discharge in rural area and its utility in the management of genital tract infection. | 2015 | 25954668 |
| anaerobic respiration: in vitro efficacy of nitazoxanide against mitochondriate acanthamoeba castellanii of the t4 genotype. | acanthamoeba is an opportunistic protist pathogen that is responsible for serious human and animal infection. being one of the most frequently isolated protists from the environment, it is likely that it readily encounters microaerophilic environments. for respiration under anaerobic or low oxygen conditions in several amitochondriate protists, decarboxylation of pyruvate is catalyzed by pyruvate ferredoxin oxidoreductase instead of pyruvate dehydrogenase. in support, nitazoxanide, an inhibitor ... | 2015 | 26297676 |
| modulatory effect of iron chelators on adenosine deaminase activity and gene expression in trichomonas vaginalis. | trichomonas vaginalis is a flagellate protozoan that parasitises the urogenital human tract and causes trichomoniasis. during the infection, the acquisition of nutrients, such as iron and purine and pyrimidine nucleosides, is essential for the survival of the parasite. the enzymes for purinergic signalling, including adenosine deaminase (ada), which degrades adenosine to inosine, have been characterised in t. vaginalis. in the evaluation of the ada profile in different t. vaginalis isolates trea ... | 2015 | 26517498 |
| characterization of specific rapd markers of virulence in trichomonas vaginalis isolates. | as for human trichomoniasis the host-parasite relationship is very complex, and the broad ranges of clinical symptoms are unlikely be attributable to a single pathogenic mechanism. specific random amplified polymorphic dna (rapd) markers of 490 bp, 720 bp and 460 bp using the primers tv-5, opa-6 and opa-11, respectively, were reported. this was the first description of possible genetic virulence markers of the infection by t. vaginalis. the aim of this study was to characterize the specific rapd ... | 2015 | 26622300 |
| genital infections and risk of premature rupture of membranes in mulago hospital, uganda: a case control study. | inflammatory mediators that weaken and cause membrane rupture are released during the course of genital infections among pregnant women. we set out to determine the association of common genital infections (trichomonas vaginalis, syphilis, neisseria gonorrhea, chlamydia trachomatis, group b streptococcus, bacterial vaginosis, herpes simplex virus type 2 and candidiasis) and premature rupture of membranes in mulago hospital, uganda. | 2015 | 26475265 |
| characteristics of women enrolled into a randomized clinical trial of dapivirine vaginal ring for hiv-1 prevention. | women in sub-saharan africa are a priority population for evaluation of new biomedical hiv-1 prevention strategies. antiretroviral pre-exposure prophylaxis is a promising prevention approach; however, clinical trials among young women using daily or coitally-dependent products have found low adherence. antiretroviral-containing vaginal microbicide rings, which release medication over a month or longer, may reduce these adherence challenges. | 2015 | 26061040 |
| changes in the contribution of genital tract infections to hiv acquisition among kenyan high-risk women from 1993 to 2012. | the objective of this study was to understand temporal trends in the contribution of different genital tract infections to hiv incidence over 20 years of follow-up in a cohort of high-risk women. | 2015 | 26125141 |
| rho gtpases as pathogen targets: focus on curable sexually transmitted infections. | pathogens have evolved highly specialized mechanisms to infect hosts. several microorganisms modulate the eukaryotic cell surface to facilitate their engulfment. once internalized, they hijack the molecular machinery of the infected cell for their own benefit. at different stages of phagocytosis, particularly during invasion, certain pathogens manipulate pathways governed by small gtpases. in this review, we focus on the role of rho proteins on curable, sexually transmitted infections caused by ... | 2015 | 26023809 |
| female reproductive hormones and biomarkers of oxidative stress in genital chlamydia infection in tubal factor infertility. | genital chlamydia infection (gci) and the associated pathologies have been implicated in tubal infertility. though the actual pathologic mechanisms are still uncertain, oxidative stress and other factors have been implicated. the purpose of the study was to determine the possible contribution of female reproductive hormones and biomarkers of oxidative stress in genital chlamydial infection to tubal occlusion. | 2015 | 25927024 |
| multipurpose prevention technologies: the future of hiv and sti protection. | every day, more than 1 million people are newly infected with sexually transmitted infections (stis) that can lead to morbidity, mortality, and an increased risk of human immunodeficiency virus (hiv) acquisition. existing prevention and management strategies, including behavior change, condom promotion, and therapy have not reduced the global incidence and prevalence, pointing to the need for novel innovative strategies. this review summarizes important issues raised during a satellite session a ... | 2015 | 25759332 |
| n-terminal presequence-independent import of phosphofructokinase into hydrogenosomes of trichomonas vaginalis. | mitochondrial evolution entailed the origin of protein import machinery that allows nuclear-encoded proteins to be targeted to the organelle, as well as the origin of cleavable n-terminal targeting sequences (nts) that allow efficient sorting and import of matrix proteins. in hydrogenosomes and mitosomes, reduced forms of mitochondria with reduced proteomes, nts-independent targeting of matrix proteins is known. here, we studied the cellular localization of two glycolytic enzymes in the anaerobi ... | 2015 | 26475173 |
| identification of cytolytic vaginosis versus vulvovaginal candidiasis. | this study aimed to observe the morphological characteristic of vaginal discharge in patients with cytolytic vaginosis (cv) under the microscope and to identify it in patients with cv and in patients with vulvovaginal candidiasis (vvc). | 2015 | 25279977 |
| high prevalence and incidence of asymptomatic sexually transmitted infections during pregnancy and postdelivery in kwazulu natal, south africa. | we report the prevalence and incidence of 3 treatable sexually transmitted pathogens (neiserria gonorrhoeae, chlamydia trachomatis, and trichomonas vaginalis) in women who were hiv infected or at high risk for hiv infection, in pregnancy and postpartum, respectively. | 2015 | 25504300 |
| incidence of curable sexually transmissible infections among adolescents and young adults in remote australian aboriginal communities: analysis of longitudinal clinical service data. | to undertake the first comprehensive analysis of the incidence of three curable sexually transmissible infections (stis) within remote australian aboriginal populations and provide a basis for developing new control initiatives. | 2015 | 25371420 |
| coinfection with chlamydia trachomatis, neisseria gonorrhoeae and trichomonas vaginalis: a cross-sectional analysis of positivity and risk factors in remote australian aboriginal communities. | to determine the co-occurrence and epidemiological relationships of chlamydia trachomatis (ct), neisseria gonorrhoeae (ng) and trichomonas vaginalis (tv) in a high-prevalence setting in australia. | 2015 | 25352691 |
| high rates of double-stranded rna viruses and mycoplasma hominis in trichomonas vaginalis clinical isolates in south brazil. | trichomonas vaginalis is the etiological agent of trichomoniasis, the most common non-viral sexually transmitted disease (std) in world, with 276.4 million new cases each year. t. vaginalis can be naturally infected with mycoplasma hominis and trichomonasvirus species. this study aimed to evaluate the prevalence of t. vaginalis infected with four distinct t. vaginalis viruses (tvvs) and m. hominis among isolates from patients in porto alegre city, south brazil. an additional goal of this study w ... | 2015 | 26160539 |
| the efficacy of 2-nitrovinylfuran derivatives against leishmania in vitro and in vivo. | despite recent advances in the treatment of some forms of leishmaniasis, the available drugs are still far from ideal due to inefficacy, parasite resistance, toxicity and cost. the wide-spectrum antimicrobial activity of 2-nitrovinylfuran compounds has been described, as has their activity against trichomonas vaginalis and other protozoa. thus, the aim of this study was to test the antileishmanial activities of six 2-nitrovinylfurans in vitro and in a murine model of leishmaniasis. minimum paras ... | 2015 | 25946239 |
| the efficacy of 2-nitrovinylfuran derivatives against leishmania in vitro and in vivo. | despite recent advances in the treatment of some forms of leishmaniasis, the available drugs are still far from ideal due to inefficacy, parasite resistance, toxicity and cost. the wide-spectrum antimicrobial activity of 2-nitrovinylfuran compounds has been described, as has their activity against trichomonas vaginalis and other protozoa. thus, the aim of this study was to test the antileishmanial activities of six 2-nitrovinylfurans in vitro and in a murine model of leishmaniasis. minimum paras ... | 2015 | 25807467 |
| polyamine quinoline rhodium complexes: synthesis and pharmacological evaluation as antiparasitic agents against plasmodium falciparum and trichomonas vaginalis. | a series of mono- and bis-salicylaldimine ligands and their corresponding rh(i) complexes were prepared. the compounds were characterised using standard spectroscopic techniques including nmr, ir spectroscopy and mass spectrometry. the salicylaldimine ligands and complexes were screened for antiparasitic activity against two strains of plasmodium falciparum i.e. the nf54 cq-sensitive and k1 cq-resistant strain as well as against the g3 isolate of trichomonas vaginalis. the monomeric salicylaldim ... | 2015 | 26226082 |
| improved antiparasitic activity by incorporation of organosilane entities into half-sandwich ruthenium(ii) and rhodium(iii) thiosemicarbazone complexes. | a series of ferrocenyl- and aryl-functionalised organosilane thiosemicarbazone compounds was obtained via a nucleophilic substitution reaction with an amine-terminated organosilane. the thiosemicarbazone (tsc) ligands were further reacted with either a ruthenium dimer [(η(6-i)prc6h4me)ru(μ-cl)cl]2 or a rhodium dimer [(cp*)rh(μ-cl)cl]2 to yield a series of cationic mono- and binuclear complexes. the thiosemicarbazone ligands, as well as their metal complexes, were characterised using nmr and ir s ... | 2015 | 25559246 |
| conservation of transit peptide-independent protein import into the mitochondrial and hydrogenosomal matrix. | the origin of protein import was a key step in the endosymbiotic acquisition of mitochondria. though the main translocon of the mitochondrial outer membrane, tom40, is ubiquitous among organelles of mitochondrial ancestry, the transit peptides, or n-terminal targeting sequences (ntss), recognised by the tom complex, are not. to better understand the nature of evolutionary conservation in mitochondrial protein import, we investigated the targeting behavior of trichomonas vaginalis hydrogenosomal ... | 2015 | 26338186 |
| stop codon recognition in the early-diverged protozoans giardia lamblia and trichomonas vaginalis. | two classes of polypeptide release factors (rfs) are responsible for maintaining accuracy in translation termination; however, their detailed mechanism of action and evolutionary history of these factors remain elusive. the structure and function of rfs vary in bacteria and eukaryotes, a fact that is suggestive of evolutionary changes in the translation termination system. giardia lamblia (diplomonada) and trichomonas vaginalis (parabasalia) are considered as early-diverged eukaryotes. the class ... | 2015 | 26310515 |