Publications

increased sensitivity for detection of carcinogen-induced dna repair with the chain terminator dideoxythymidine.		1978	100116
dna synthesis in toluene-treated bacteriophage-infected minicells or bacillus subtilis.	bateriophage (phi29, spp1, or spo1)-infected, toluene-treated minicells of bacillus subtilis are capable of limited amounts of non-replicative dna synthesis as measured by incorporation of [3h]dttp into a trichloroacetic acid-precipitable form. the [3h]dttp is covalently incorporated into small dna fragments which result from the degradation of a small percentage of the infecting phage genomes (molecular weights in the range of 2 . 10(5)). short exposure of the dna molecules containing the incor ...	1978	100140
development of glycogen and phospholipid metabolism in fetal and newborn rat lung.	glucose, a major metabolic substrate for the mammalian fetus, probably makes significant contributions to surface active phospholipid synthesis in adult lung. we examined the developmental patterns of glycogen content, glycogen synthase activity, glycogen phosphorylase activity and glucose oxidation in fetal and newborn rat lung. these patterns were correlated with the development of phosphatidylcholine synthesis, content and the activities of enzymes involved in phosphatidylcholine synthesis. f ...	1978	100141
[carbonic anhydrases of bovine erythrocytes: comparative study of the anhydrase and esterase activity of different forms].	comparative study of esterase activities (p- and o-nitrophenylacetate) allowed to characterize three groups of bovine erythrocyte carbonic anhydrases:--the first one includes ci, cii (isozyme of ci) and cir ("artificial" product of ci).--the second one includes native civ1 and "artificial" civ1, first conformational variants of ci,--finally civ2, second "artificial" conformational variant of ci. possible modifications of the enzyme site between the first and the other enzyme groups are discussed ...	1978	100147
control of cell multiplication: preparation and immunological comparison of inhibitory factors in the homogenate and perfusate of the adult rat liver.	the control of organ cell multiplication by a negative feed-back mechanism implies that factors of the inhibitory mechanism are present in the blood and are produced by the target organ itself. we have examined the inhibitors which are present in the cytosol of adult rat liver as well as in efferent fluid from an isolated perfused organ. these two materials yielded predominantly protein molecules having in common a molecular weight of approximately 80 000 daltons and an isoelectric point between ...	1978	100149
[redox processes in allergic reactions of the delayed type to microbial antigens].	the influence of common allergic response of delayed type to brucellosis antigen on the processes of glycolysis and dehydrogenase activity of krebs' cycle in guinea pigs' blood and organs was studied. along with inhibitory activity of four dehydrogenases investigated there was a depression of the glucolysis processes connected with reduction of the lactate, pyruvate content, and with depression of the ldh activity. an increase of the anaerobic fractions and lowering of aerobic fractions content ...	1978	100150
hypophysial responses to continuous and intermittent delivery of hypopthalamic gonadotropin-releasing hormone.	in rhesus monkeys with hypothalamic lesions that abolish gonadotropic hormone release by the pituitary gland, the constant infusion of exogenous gonadotropin-releasing hormone (gnrh) fails to restore sustained gonadotropin secretion. in marked contrast, intermittent administration of the synthetic decapeptide once per hour, the physiological frequency of gonadotropin release in the monkeys, reestablishes pituitary gonadotropin secretion. this phenomenon is attributable to the pattern of gnrh del ...	1978	100883
beta-lactam antibiotics. ii. structure-activity relationships of 6-[alpha-(alpha'-ureido-acylamino) acylamino] penicillanic acids.	the influence on the structure-activity relationships (s.a.r.) of the stereochemistry and various alkyl, aryl, aralkyl and heterocyclic substituents at the two chiral centres in the dipeptide side-chain of a new series of penicillins was examined. in many cases the effects of these changes had a pronounced influence on the degree of activity against gram-positive and especially gram-negative bacteria. several compounds indicated that the size, shape and spatial disposition of a substituent were ...	1978	101499
inhibition of bacillus subtilis spore germination by various hydrophobic compounds: demonstration of hydrophobic character of the l-alanine receptor site.	l-alanine-initiated germination of bacillus subtilis spores was inhibited by various kinds of hydrophobic compounds. good correlation of inhibitory effect with hydrophobicity of the compound was demonstrated by using regression analysis in which the hydrophobic character was expressed by the partition coefficient in an octyl alcohol-water system. the correlation coefficient for 20 alcohols was 0.959, and that for 19 miscellaneous compounds was 0.906. regression lines of the alcohols and other hy ...	1978	101524
linkage map of pseudomonas aeruginosa pat.	the locations of new markers relative to markers previously mapped on the chromosome of pseudomonas aeruginosa strain pat were defined by generalized transduction with phage f116l and f1083. although the marker orders of the various marker groups were deduced mainly from the results of two-factor crosses, the locations of a number of markers were confirmed by three-factor crosses. a linkage map of the chromosome of p. aeruginosa pat was constructed which shows the relative locations of 50 genes. ...	1978	101525
tunicamycin-resistant mutants and chromosomal locations of mutational sites in bacillus subtilis.	the types of tunicamycin-resistant mutants of bacillus subtilis were analyzed, and their mutational sites on the chromosome were mapped. a type 1 mutation that simultaneously expressed hyperproductivity of extracellular alpha-amylase was located close to amy e. type 2 mutations were near aroi.	1978	101533
astrovirus-associated gastroenteritis in children.	in a small astrovirus-associated outbreak of gastroenteritis in a ward of a local children's hospital two out of five children with symptoms excreted astrovirus particles. no astrovirus particles were found in faeces from the remaining asymptomatic child, and no other viral or bacterial pathogens were found in any of the children. virus excretion persisted for only a few days. rising antibody titres to the astrovirus particles were demonstrated in one child, and igm was also demonstrated in this ...	1978	101556
regulation of immunoglobulin biosynthesis in the murine plasmacytoma mopc 315.	we have examined certain aspects of igg biosynthesis by constructing hybrids between mpc11 (gamma2b, kappa) and mopc 315 (alpha,lambda2) that have lost the ability to synthesize one or the other heavy chain. cells express the three chains in a stable fashion, and both autologous (parental) and heterologous (nonparental) h and l chain pairs form and are secreted. the alpha h chain was found in polymeric form when associated with the heterologous kappa l chain. the lambda2 l chain covalently assem ...	1978	101592
[epidemiological study on beta hemolytic streptococci among healthy school children in toda city, saitama (author's transl)].		1978	101618
demonstration of fibronectin in human cerebrospinal fluid.	fibronectin is a glycoprotein found in plasma (cold-insoluble globulin), connective tissues, and cultures of fibroblasts and astroglial cells. this paper describes the identification of fibronectin in human csf. fibronectin in csf was immunologically indistinguishable from the plasma form, as shown by double-diffusion analysis and by radioimmunoassay specific for fibronectin. fibronectin was isolated from human csf by affinity chromatography on sepharose-coupled gelatin and was further analyzed ...	1978	101631
behavioral and dermatologic changes and low serum zinc and copper concentrations in two premature infants after parenteral alimentation.	two premature infants were observed to develop behavioral and dermatologic changes and low serum zinc and copper concentrations following cessation of prolonged parenteral alimentation, while being fed exclusively with human milk. following treatment with exogenous oral zinc supplementation, prompt relief of symptoms and increases of serum zinc and copper concentrations were observed in both infants. these patients comprise about 5% of our premature infants who are treated with parenteral alimen ...	1978	101647
inhibition of human seminal fluid dna polymerase by an igg fraction of seminal plasma from vasectomized men.	immunoglobulin g (igg) was isolated from ejaculates of intact and vasectomized men by precipitation with ammonium sulphate and deae-cellulose ionexchange chromatography. velocity centrifugation revealed that all of the igg from intact males was 7s protein while less than 40% of the seminal igg of vasectomized men cosedimented with the 7s marker; the remaining, immunologically unidentifiable, protein was considerably smaller and heterogeneous in size. only the 7s igg from the post-vasectomy ejacu ...	1978	101659
l-form of pseudomonas aeruginosa. 2. antibiotic sensitivity of l-forms and their parent forms.		1978	101702
weight and size of the placenta in cynomolgus monkeys (macaca fascicularis).	a gross anatomical survey of the placental development was carried out in 24 cynomolgus monkeys (macaca fascicularis) of 4, 5, 6, 7, 8, 9, 10, 15 and 20 weeks of gestational age. eight of the 24 placentas examined were found to be single discoidal and the remaining 16 bidiscoidal. the weight and size of placentas of each animal were measured. the average weight of the 20th week placentas was about 94 times heavier than that of the 4th week ones; the average diameter of the former was about 5 tim ...	1978	101705
studies on virus-inhibiting substances of bacterial origin. iv. antiviral substances extractable from streptococcus faecalis: its in vivo effect.		1978	101714
studies on virus-inhibiting substances of bacterial origin. i. introduction.		1978	101715
studies on virus-inhibiting substances of bacterial origin. ii. inhibition of animal virus plaque formation by culture filtrates of lactic acid bacteria.		1978	101716
demonstration of adrenergic catecholamine receptors in rat myometrium and their regulation by sex steroid hormones.		1978	101725
[surgical and dietetic problems of subtotal resection of the small intestine in adults (author's transl)].	the human body badly tolerates the extensive loss of the small intestine by resection. malabsorption of various substances is followed by severe deficiency symptoms. in recent years a longer survival with a satisfactory general condition was achieved by intensive postoperative care and adequate diet--in our own cases even in adults and in old age.	1978	101816
[therapy of prostato-vesiculitis].		1978	101836
effect of diet on adhesion and invasion of microflora in the intestinal mucosa of chicks.		1978	101987
short-term memory in the rhesus monkey: effects of dopamine blockade via acute haloperidol administration.	the effects of dopaminergic blockade on recent or short-term memory (stm) were evaluated in test-sophisticated rhesus monkeys. each monkey was tested under several doses of the antidopaminergic haloperidol (0.006 to 0.05 mg/kg), in an automated, delayed-response procedure. the same procedure and test apparatus had previously been used to demonstrate profound stm impairments in aged rhesus monkeys and strikingly similar deficits in young monkeys given the anticholinergic scopolamine. the results ...	1978	101990
undersea psychophysiologic reactions of human organism.	the determinations carried out on 12 divers during the immersion into the sea to a depth between 7 and 29 m, as well as on controls in immersions at 4 m revealed a significant prolongation of the visual reaction time and a marked tachycardia. the changes were more marked at great depths and if exercise was superimposed over hyperbaric stress. a rise in the urinary excretion of 17-hocs and vanillylmandelic acid and an impairment of the manual dexterity were also found during immersions. the resul ...	1978	101994
the retention and distribution of 241am and 65zn, given as dtpa chelates in rats and of [14c]dtpa in rats and beagles.		1978	102009
subglottic edema in acute epiglottitis in children.	analysis of airway radiographs of 20 children with proven acute epiglottitis revealed that five (25%) had, in addition to supraglottic edema, localized subglottic edema radiographically indistinguishable from that seen in croup. in all five patients the etiologic organism was hemophilus influenzae type b.	1978	102148
comparison of the in vitro activity of bay k 4999 and piperacillin, two new antipseudomonal broad-spectrum penicillins, with other beta-lactam drugs.	bay k 4999 and piperacillin, two new substituted ampicillins, were compared with other beta-lactam antibiotics, including carbenicillin, azlocillin, mezlocillin, benzylpenicillin, ampicillin, and cefoxitin, against a wide range of gram-positive and -negative organisms. bay k 4999 and piperacillin were extremely active against pseudomonas aeruginosa (50% inhibited by 2 mug/ml), being about 16-fold more active than carbenicillin. bay k 4999 was the most active drug against escherichia coli (50% in ...	1978	102245
interaction of the nitrogenase components of anabaena cylindrica with those of clostridium pasteurianum.		1978	96817
5-thio-d-glucose is an acceptor for udp-galactose : d-glucose 1-galactosyltransferase.		1978	96819
skunks have gene sequences in their cellular dna related to squirrel monkey retrovirus: transmission between species of a new world primate endogenous type d retrovirus.		1978	96832
indirect chromosomal fluorescence with antibody to 7, 12-dimethylbenz(a)anthracene.		1978	96836
genetics of complement deficiencies associated with lupus-like syndromes.	there appears to be an association between deficiencies of a number of complement components, particularly of the second component (c2), and rheumatic diseases, especially lupus. the meaning of this association is not clear, but the linkage of deficiency of c2 with hla, especially hla-a10, b18, dw2, as well as with bfs, suggests a possible linkage to immune response genes.	1978	96843
differential effects of prostaglandin synthetase stimulators on inhibition of cyclooxygenase.	the different effects of prostaglandin synthetase stimulators on inhibition of the cyclooxygenase by structurally distinct classes of nonsteroidal antiinflammatory agents suggest that the enzyme is altered by interaction with these stimulators. reversible stimulation of prostaglandin synthetase activity by phenols and some other compounds and the relative influence of these stimulators on inhibitors of the cyclooxygenase were determined quantitatively. two distinct classes of inhibitors were est ...	1978	96853
phycobiliprotein synthesis in protoplasts of the unicellular cyanophyte, anacystis nidulans.	stable and metabolically active protoplasts were prepared from the unicellular cyanophyte, anacystis nidulans, by enzymatic digestion of the cell wall with 0.1% lysozyme. the yield of protoplasts from intact algal cells was approx. 50%. incorporation of l-[u-14c]leucine into cold trichloroacetic acid-insoluble material from protoplasts preparations was linear for 1.5 h and continued for an additional 2.5 h. incorporation of radiolabeled leucine into hot trichloroacetic acid-insoluble material fr ...	1978	96857
comparison of effects of normal rabbit sera and anti-cock sperm sera on rabbit sperm, including comparison of effects on the sex ratio.		1978	96880
fibrinogen and adp-induced platelet aggregation.		1978	96891
metabolism studies with practolol [proceedings].		1978	96899
effects of thyrotropin releasing hormone, norepinephrine and acetylcholine on the activity of neurons in the hypothalamus, septum and cerebral cortex of the rat.		1978	96915
bovine transferrin glycopeptide: the relevance of its structure to interaction with the mammalian hepatic lectin that binds asialoglycoproteins.		1978	96919
experimental polychlorinated biphenyl toxicosis in germfree pigs.	the effects of polychlorinated biphenyls were studied in eight germfree pigs. beginning at fourteen days of age, two pigs each were fed daily 12.5, 25, 50 and 100 mg/kg body weight of polychlorinated biphenyls as aroclor 1254. three germfree pigs were negative controls. clinically the treated pigs had inappetance, a hemorrhagic diarrhea, erythema of the nose and the anus, retarded growth, distended abdomen and at the higher dose levels, incoordination and coma followed by death. deaths occurred ...	1978	96924
test for differentiation of m. tuberculosis and m. bovis from other mycobacteria.	a test is described for selective inhibition of mycobacterium tuberculosis and m. bovis isolates in fluid medium. the method employs rho-nitro-alpha-acetyl-amino-beta-hydroxy-propiophenone (nap) as an inhibitory agent for differentiation of mammalian tuberculosis strains from other mycobacteria.	1978	96930
[chemical reactivity and biological properties of a series of aminochlorambucil derivatives].	the substitution of aminochlorambucil by a methyl group increased the chemical reactivity in iv b (n = 1) and iv b (n = 2) but their cytotoxicity remained low. the immunosuppressive effect (adjuvant arthritis in rats and tuberculin related skin reaction) was observed with iv b (n = 2). aminochlorambucil was effective on adjuvant arthritis only and iv b (n = 1) had no activity. aminochlorambucil, iv b (n = 1) and iv b (n = 2) were devoid of any non-specific anti-inflammatory activity.	1978	96958
[permissivity of the rat (rattus rattus) of guadeloupe with regard to schistosoma mansoni and evidence for migration of adult schistosomes to the lungs].	in contrast to the laboratory rat, the rat (rattus rattus) of guadeloupe is a favorable host for the life cycle of s. mansoni: the parasite population is maintained at a high level (between 8 and 16% in this host until the 16th week and reproduces normally). the evolution of the parasitose is marked, shortly after the 8th week, by a transfer of schistosomes from the liver to the lungs.	1978	96960
[toxicity of bacillus thuringienses var. israelensis for larvae of aedes aegypti and anopheles stephensi].	the comparative study of the larvicidal action of b. thuringiensis var. israelensis on a. aegypti and a. stephensi shows the greater sensitivity of a. aegypti, with 100% of mortality in 30 to 40 min. at high doses. but, for both species of mosquito, the toxicity of these bacteria is very high, as shown by the mortality regression curves and by the lc50. this toxicity is associated with the crystals and can be extracted from them by dilute alkali solution, like the general case of the other serot ...	1978	96979
[lymphocyte subpopulations in adjuvant arthritis of rats. effects of corticoids and gamma irradiation].	experimental model of human chronic inflammatory arthritis, adjuvant arthritis may be induced only in several strains of inbred rats: it is well developed in lew and practically absent in wag. after adjuvant injection, the pha-stimulable lymphocytes subpopulation quite disappears from the blood, if polyarthritis is well developed. these cells are probably capted in the tissues implicated in immunological conflict. on the contrary, the cona-stimulable subpopulation is enhanced in both strains aft ...	1978	96995
[modifications in the type distribution of muscle fibers induced by repeated local freezings the rat sciatic nerve].	in the rat, after a localized freezing of the sciatic nerve inducing a complete denervation of the medial head of the gastrocnemius muscle, the reinnervation took place within 16-18 days under our experimental conditions. after only one freezing, a limited and stable "type-grouping" of muscle fibres is observed from 30 to 360 days. after 2 to 5 freezing repeated every three weeks, the muscular changes observed one month after the last freezing are much more pronounced than when only one freezing ...	1978	96998
[cutaneous respiration in a selachian (scyliorhinus caniculus l.)].	cutaneous oxygen consumption (mo2) and cutaneous oxygen uptake from the external medium were investigated in an elasmobranch scyliorhinus caniculus l. in spite of an important mo2 (2.75 +/- 0.28 nmol.mn-1 cm-2 ; n=6) a positive net flux of oxygen through the skin takes place (2.98 +/- 0.33 nmol. mn-1 .cm-2). the skin of the dogfish in an exchanger for oxygen supplying 10% of oxygen requirements of other organs of the body in these experimental conditions (t = 13 degrees c).	1978	97014
[protective action on mice of acellular extracts from salmonella typhimurium].	acellular fractions obtained by saline extraction at 60 or at 100 degree c of salmonella typhimurium protect mice against an experimental infection with the homologous strain. after purification, these fractions which are complex, might be used for the development of a vaccine.	1978	97021
thyrotropin-releasing hormone (trh): lack of effect on shock-elicited fighting (sef) in rats.		1978	97048
local cerebral energy metabolism: its relationships to local functional activity and blood flow.	the results of studies with the [14c] deoxyglucose technique unequivocally establish that local functional activity in cerebral tissues is, as in other tissues, closely coupled to the local rate of energy metabolism. stimulation of local functional activity increases the local rate of glucose utilization; reduced functional activity depresses it. local cerebral blood flow is normally distributed among the cerebral structures in almost exact proportion to their rates of glucose utilization and it ...	1978	97062
antibody against rabbit immunoglobulin vh and l chain allotype determinants in heterologous anti-ig antisera.	heterologous anti-rabbit igg antisera have been examined by radioimmunoassay for the occurrence of anti-vh antibody. most of the sera contained antibody specific for vh allotype determinants (aal). the antisera contained as much or more anti-al antibody as estimated in conventional alloantisera. it has further been shown that the anti-l chain antibody in all these sera was specific for l chain allotype determinants. antibody against h chain-dependent l chain conformational determinants or cross- ...	1978	97086
coagulation changes following vasectomy: a study in primates.	thirty vasectomized rhesus monkeys were tested for changes in coagulation factors that might reflect an increased incidence of thrombosis. the results of tests on these monkeys were compared with results of tests on 18 control rhesus monkeys; there were no significant differences between control and vasectomized animals for any of the parameters tested. one vasectomized animal had increased levels of fibrin monomer in his plasma on repeated samples, but no evidence of thrombosis on postmortem ex ...	1978	97098
[nature of the mutations that determine the ability of bacillus subtilis a-50 to sporulate at high glucose concentrations in the medium].	the ability of bacillus subtilis a-50 to sporulate in the medium containing high glucose concentrations is caused by at least two mutation types: pts mutations and cat (or tgl) mutations, both of them affecting differently the level of alkaline proteinase synthesis. the decrease of the level of enzyme activity in the case of pts mutation (glur3 mutant) occurs at the expense of glucose transport disturbance. the mutation cat (tgl) (mutant glur5) causes the increase in enzyme synthesis at the expe ...	1978	97172
[soil foci of anthrax in kiev province and their sanitation].		1978	97175
non-transformable mutants of bacillus subtilis defective in the penetration of dna into the cell.	four non-transformable mutants of bacillus subtilis 168 defective in the penetration of dna into the recipient cell were isolated. all mutants were fully non-transformable with mutation in genes influencing irreversible binding of the donor dna by the recipient cell.	1978	97186
cytogenetics and taxonomy of some south bolivian monkeys.	illustrations are given by the authors of chromosome banding patterns of three species of monkeys: douroucouli, black-capped capuchin and squirrel monkey. the precise locality of the animals in southern bolivia is known. this enables a taxonomic discussion on the value of some names of these animals.	1978	97192
[the appearance of penicillin resistant gonococci. clinical, genetic and epidemiologic problems].		1978	96408
[tuberculin reactions in guinea pigs injected with virulent and avirulent tubercle bacilli].		1978	96433
pre-proparathyroid hormone; amino acid sequence, chemical synthesis, and some biological studies of the precursor region.	the precursor of bovine proparathyroid hormone was synthesized by translation of parathyroid mrna in a wheat-germ cell-free system. the amino acid sequence of the nh2-terminal extension (the pre sequence) was determined by repetitive edman degradation of the polypeptide labeled with radioactive amino acids (radiosequencing). the pre sequence of pre-proparathyroid hormone is (formula: see text) which is followed by the sequence of proparathyroid hormone. it is significant that 20 of the 25 amino ...	1978	96437
chromosomal locations of mouse immunoglobulin genes.	the chromosomal locations of the structural genes coding for the constant portions of mouse heavy (h) and light chain immunoglobulins were studied by molecular hybridization techniques. complementary dna probes containing the constant-region sequences of kappa and lambdai light chain and alpha, gamma2b, and mu heavy chain mrnas were annealed to a large excess of dna from a series of eight mouse-human hybrid cell lines that are deficient for various mouse chromosomes. the lines were scored as pos ...	1978	96442
direct demonstration of immunoglobulin kappa chain rna in thymus t cells by in situ hybridization.	mouse thymuses with more than 99% t cells have been reported to contain immunoglobulin kappa mrna-like molecules (kappa rna) in relatively large quantities. the present study was undertaken to rule out the possibility that the kappa rna was mainly a product of a few contaminating b cells of the thymus and to determine whether all t-cell subpopulations contained kappa rna. by in situ hybridization with dna complementary to kappa mrna (kappa cdna) the following observations were made: 98.5% of thy ...	1978	96443
the effects of methylphenidate on repeated acquisition of serial discrimination reversals.	rats were trained to bar-press for sucrose solution in the presence of one of two stimulus conditions. on each daily training session, the stimulus during which bar-pressing was reinforced was reversed. the subjects were trained in this serial discrimination reversal procedure until successive acquisitions of the discrimination had stabilized. drug treatments consisting of saline or 0.25, 1.0, 2.0, 4.0, 6.0 or 8.0 mg/kg of methylphenidate were then administered 20 min prior to the daily training ...	1978	96462
effect of intracerebroventricular bradykinin, angiotensin ii, and substance p on multiple fixed-interval fixed-ratio responding in rabbits.		1978	96474
a comparison of the effects of 50 mevd leads to be neutron and cobalt-60 irradiation of the kidneys of rhesus monkeys.	twenty rhesus monkeys had one kidney irradiated (after undergoing unilateral nephrectomies) with one of four doses: 960 or 1080 rads of 50 mevd leads to be neutrons, or 2350 or 2700 rads of 60co. whereas animals treated with the lower dose of neutrons or 60co are alive with relatively normal renal function, those treated with the higher dose of neutrons died of radiation nephritis. animals treated with the higher dose of 60co developed radiation nephritis but survived. the physiological and hist ...	1978	96490
chelation in metal intoxication. vi. influence of pas and cdta on the excretion of manganese in rabbits given mno2.	the success of p-aminosalicyclic acid (pas) and 1,2-cyclohexylene dinitrilotetraacetic acid (cdta) in the mobilization of manganese from some vital organs and their subcellular fractions of manganese-intoxicated rats, led to the two compounds beng further investigated individually and in combination for their efficacy in influencing excretion of manganese in rabbits given mno2. these chelating agents led to a higher excretion of manganese through faeces than urine. whereas cdta was able to enhan ...	1978	96549
[diagnosis of vibriosis in bulls at breeding stations through lavages of the artificial vagina].	the objective of the study was to test the suitability of lavages of artificial vaginas which are used for collecting ejaculate for diagnosing the campylobacter fetus subsp. fetus germs. according to the results of the investigation this method may be considered equal to the method of lavages of the prepuce. however, it is important to point out the advantages: it eliminates the danger of an accident, it enables quality lavage in the laboratory. to caputure the campylobacter fetus the filtration ...	1978	96573
[study of the spiral and spindle-shaped formations in cultures of bacillus larvae (white 1906) causing foulbrood in bees].	the authors have been studying the bacterial diseases of the brood for a fairly long time. american and european foul brood has been studied with the highest attention. cultures of bacillus larvae (white, 1906) were examined both in freshly isolated strains and in collection strains of this micro-organism. in cases of foul brood, the pathological material was found to contain not only the typical rods of b. larvae but also immobile spiral forms which are usually referred to in literature as frag ...	1978	96576
a sarcocystis-like protozoon in a sheep with lymphadenopathy and myocarditis.	a generalized enlargement of the lymph nodes was found in an emaciated adult ewe. additional autopsy findings included tiny grey-white necrotic foci in the heart muscle, aspiration pneumonia and diffuse pleuritis. light microscopy showed a generalized lymphadenopathy with perilymphadenitis, depletion of lymphocytes and histiocytosis of the lymph node. in histiocytes and vascular endothelial cells of lymph nodes, septal capillary endothelium of lungs and capillary endothelium of myocardium, early ...	1978	96578
development of visual acuity in infant monkeys (macaca nemestrina) during the early postnatal weeks.		1978	96592
[hyaluronidase in meningococcus].	a total of 204 meningococcus strains were tested for the presence of hyaluronidase, and 45.5% of the strains were found to contain it. strains penetrating into the cerebrospinal fluid were the ones which largely produced the enzyme (in 83% of the cases). the enzyme was revealed only in 25.5% of the strains habituating on the nasopharyngeal mucosa. hyaluronidase was mostly found in the meningococcus strains referred to the serological group a; strains of other serological groups and ungrouped str ...	1978	96634
[participation of r plasmids in the transfer of chromosome genes].		1978	96640
pituitary-adrenal response to stimulation of the limbic system and lateral hypothalamus in the rhesus monkey (macacca mulatta).	various sites within the limbic system, frontal lobe and lateral hypothalamus of the rhesus monkey brain were electrically stimulated using chronically implanted electrodes. increases in plasma cortisol was observed after stimulation of the lateral hypothalamic area, basolateral amygdala, pyriform cortex, hippocampus, certain sites in the cingulate gyrus and orbital part of the frontal lobe. inactive sites included the caudate nucleus, putamen and white matter in the frontal lobe.	1978	96644
electron-microscopic studies on primate neurons: microtubule-pigment associations.	the relationship between microtubules and the lipoprotein pigment found in senile cynomolgus brain and senile human brain biopsy material was investigated. numerous microtubules were present in all parts of the cytoplasm and within the pigment areas, running parallel or obliquely to the pigment bodies and being associated with its lateral aspects. microtubules also occurred in the periphery of neurons or appearing to enter the perineuronal oligodendrocytes. these observations indicate a possible ...	1978	96651
the double flash erg during adaptation to the dark.	electroretinogram (erg) of albino rabbits and rheusus monkeys were recorded in a dark room applying the double flash stimuli after a sufficient adaptation to light. the stimulus intervals of the flashes were varied. the per cent amplitudes of the ergs for the first flashes (b1) and those of the second flashes (b2) were plotted against time, as was (b1-b2)/b1 (=k). 1. b1 was independent of the stimulus interval in both species, and increased with lapse of time to reach a plateau. 2. b2 was quite ...	1978	96656
animal-human correlates of narcotic dependence: a brief review.	knowledge of opiate action in laboratory animals can be of great value in developing a rational clinical approach to the treatment of narcotic dependence. physiological alterations experimentally produced by narcotics have been confirmed in human subjects, and classical laboratory effects of conditioning and operant behavior also have clinical counterparts. realization of animal-human correlates of narcotic dependence allows a better understanding of the strengths and weaknesses of existing ther ...	1978	96703
free flap in an experiment - a histological view.		1978	88142
[determination of antigen structures of pasteurella multocida: the preparation of vaccines].	the discovery of the role played by somatic antigens of the pasteurella multocida a and d capsular types in the immunization of susceptible species makes it necessary to type the somatic antigens of the isolated strains prior to any action to induce active or passive immunity. only immunoprecipitation in gel was chosen out of the various typing techniques proposed, and a correlation was established between the capsular types (according to carter), somatic types (according to namioka) and types d ...	1978	89055
relationship between cellular autolytic activity, peptidoglycan synthesis, septation, and the cell cycle in synchronized populations of streptococcus faecium.	synchronized, slowly growing (td = 70 to 80 min) cultures were used to study several wall-associated parameters during the cell cycle: rate of peptidoglycan synthesis, septation, and cellular autolytic activity. the rate of peptidoglycan synthesis per cell declined during most of the period of chromosome replication (c), but increased during the latter part of c and into the period between chromosome termination and cell division (d). an increase in cellular septation was correlated with the inc ...	1978	96095
tryptophan residues of saccharifying alpha-amylase from bacillus subtilis. a kinetic discrimination of states of tryptophan residues using n-bromosuccinimide.	four tryptophan residues of saccharifying alpha-amylase from b. subtilis out of eleven in total are reactive towards n-bromosuccinimide (nbs), suggesting that they are on the surface of the enzyme. this is consistent with the results of solvent perturbation difference spectrophotometry with ethylene glycol. one of four tryptophan residues was clearly distinguished from the other three in reactivity with nbs by the stopped-flow method. this most reactive tryptophan residue was not protected from ...	1978	96111
naturally occurring diatomaceous pneumoconiosis in sub-human primates.		1978	96157
laboratory investigations of an epidemic of acute haemorrhagic conjunctivitis in bombay and poona in 1975.		1978	96187
l-alanyl-l-tyrosine as a tyrosine source during intravenous nutrition of the rat.	tyrosine is considered an essential amino acid for some premature infants, but its limited solubility prevents addition to intravenous solutions in adequate amounts. tyrosine peptides with solubilities greater than tyrosine were synthesized to evaluate potential for intravenous use. intraperitoneal injection of l-alanyl-l-[u-14c]tyrosine (0.5 mmoles/kg) into adult rats resulted in a rapid labeling of tissue pools and production of 14c-co2. when the peptide was infused as part of an intravenous n ...	1978	96233
[morphology of ribosomal rna in chicken fibroblasts].	it is shown with the electron microscope that the 28 s rna component of the ribosomal rna extracted from chicken fibroblasts contains secondary structures which are not present in the 18s component.	1978	95896
[demonstration of erythroblastic differentiation after 14 days in blood in vitro during vaquez's disease without addition of erythropoietin].	leucocytes of normal individuals and patients with polycythemia vera were isolated from the peripheral blood by ficoll-hipaque density gradient centrifugation and cultured in vitro suing the bovine plasma clot culture technique with a minor modification: the addition of fresh normal serum. after 14 days in the presence of sheep erythropoïetin (3u/ml) erythropoïetic bursts containing between 3 and 10 subcolonies were observed in normal and polycythemia vera cultures. blood leucocytes of patients ...	1978	95898
the effect of blood on ocular fundus reflectance and determination of some optical properties of retinal blood vessels.	light reflected from 50 micrometer diameter spots on the fundi of two adult rhesus monkeys was measured as a function of wavelength in 10 nm jumps from 400 to 900 nm. the areas measured were a retinal artery and vein, areas of the disk, macula, and retina devoid of visible blood vessels, and the foveola. the eyes of the two monkeys were then exsanguinated, the blood vessels were filled with normal saline, and reflectances of the same spots on the fundi were again measured. the pairs of reflectan ...	1978	96040
comparison of the effect of vasopressin infusions on the mesenteric arteries of different species.	superior mesenteric arteriography was performed following infusions of vasopressin, epinephrine and saline into the superior mesenteric arteries of dogs, pigs, rabbits and monkeys and compared with the well-known effects in human beings. species-specific effects were noted and compared with the known differences in various vascular beds in human beings. in non-primate animals, vasopressin appeared to act at a more distal site than in primates, but with a similar decrease in superior mesenteric a ...	1978	96042
selective vascular thrombosis induced by a direct electrical current: animal experiments. first clinical trials.		1978	90140
[neural secretion of histamine by the gastric mucosa and its effects on gastric motility].		1978	90747
does alpha-fetoprotein influence the immune response?		1978	94254
the regulation of the immune response of mice to haemophilus influenzae type b capsular polysaccharide.	the regulation of age-related antibody response to haemophilus influenzae type b polysaccharide (hitb-ps) was studied by measuring the splenic plaque forming cells (pfc) following immunization with this capsular polysaccharide. the magnitude of pfc response to hitb-ps was found to be dose-related, enhanced by freund's complete adjuvant and influenced by the genetic strain of mice. priming with a low dose of hitb-ps did not induce a state of immunological unresponsiveness. treatment with antilymp ...	1978	75178
intrinsic tritium labeling of the capsular polysaccharide antigen of haemophilus influenzae type b.	the capsular polysaccharide of haemophilus influenzae type b was intrinsically labeled with tritium by a microculture technique with 6-3h-d-glucose and was isolated in radioantigenically pure form by a combination of selective precipitation and molecular sieve chromatography. labeling with tritated sugar residues approached one-fourth maximum and produced a specific activity 10-fold that previously described for extrinsic labeling methods. in radioantigen-binding assays for antibody, sensitivity ...	1978	75930
r-factor involvement in a local outbreak of ampicillin-resistant haemophilus influenzae infections.	in a swedish nursery 11 of 15 children harboured non-encapsulated haemophilus influenzae in their nasopharynx. six children had ampicillin-resistant and beta-lactamase-producing isolates. five of these children had otitis whereas one was healthy. in order to identify the origin of the h. influenzae isolates their o-antigen determinants were studied by an immunodiffusion technique. 18 different rabbit antisera were used. for each isolate an o-antigen pattern was recorded. five of the 6 resistant ...	1978	76336
antibiotic antagonism and synergy.		1978	78302
significance of noncapsular antigens in protection against experimental haemophilus influenzae type b disease: cross-reactivity.	a bacterial strain, tentatively identified as an actinobacillus species, was found to asymptomatically colonize the pharynx of some rats and to bear cell wall antigens which cross-react with noncapsular antigens of haemophilus influenzae type b (hib). the cross-reacting antigens appeared to be a heterogeneous mixture with varying molecular size and charge. the antigenic moieties are probably carbohydrate in nature. antisera raised with this strain had both immunochemical and biological (bacteric ...	1978	80382
early splenomegaly in homozygous sickle-cell disease: an indicator of susceptibility to infection.	135 children with homozygous sickle-cell (ss) disease diagnosed at birth have been followed for 1--5 years. severe bacterial infections were confined to those in whom the spleen was first palpable at or before 1 year of age and were commonest in those in whom the spleen was first palpable at or before age 6 months. regular follow-up of children with ss disease diagnosed at birth will identify children particularly at risk of severe infections.	1978	81988
penicillin today.		1978	82094