Publications

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[human papillomavirus vaccines].to assess the efficacy, the tolerance, the duration of protection and the limitations of papillomavirus vaccines and to determine the potential indications for prophylactic vaccination.200818187268
human papillomavirus vaccine and cervical cancer prevention: practice and policy implications for pharmacists.to review the epidemiology and natural history of human papillomavirus (hpv), summarize relevant clinical trials of the prophylactic hpv vaccines, and describe the practice and policy implications that hpv vaccine represents for pharmacists.200818192123
prevalence of mucosal and cutaneous human papillomaviruses in different histologic subtypes of vulvar carcinoma.two independent pathways of vulvar carcinogenesis have currently been identified, one related to infection with mucosal human papillomaviruses (hpvs) and a second related to chronic inflammatory or autoimmune processes. the goal of the study was to examine a possible role of cutaneous hpvs from the beta genus in vulvar carcinogenesis and to evaluate the distribution of intratypic variants of hpv 16 in hpv 16-positive vulvar cancer. consecutive cases of vulvar carcinoma were retrieved from the fi ...200818192968
development of a photodiode array biochip using a bipolar semiconductor and its application to detection of human papilloma virus.we describe a dna microarray system using a bipolar integrated circuit photodiode array (pda) chip as a new platform for dna analysis. the pda chip comprises an 8 x 6 array of photodiodes each with a diameter of 600 microm. each photodiode element acts both as a support for an immobilizing probe dna and as a two-dimensional photodetector. the usefulness of the pda microarray platform is demonstrated by the detection of high-risk subtypes of human papilloma virus (hpv). the polymerase chain react ...200818193408
short-fragment pcr assay for highly sensitive broad-spectrum detection of human papillomaviruses in laryngeal squamous cell carcinoma and normal mucosa: clinico-pathological evaluation.the aim of the study was to determine the prevalence and genotypes of hpv infection in laryngeal cancer specimens, normal mucosa obtained from the surgical margin and laryngeal nodules using a novel high sensitive and specific spf(10) hpv dna test, pcr/deia method and inno-lipa genotyping assay. the correlation between hpv presence and clinico-pathological features was analyzed. tissue samples were collected from 93 primary laryngeal squamous cell carcinoma (lscc), 49 specimens of normal mucosa ...200818193443
[immunization schedule of the spanish association of pediatrics: recommendations 2008].the vaccine advisory committee of the spanish association of pediatrics provides information on the new developments in vaccines that have taken place in 2007, based on the available evidence, and discusses these developments. certain modifications to the immunization schedule for 2008 are recommended. a second varicella vaccine booster dose, administered together with the booster dose of the measles-mumps-rubella (mmr) vaccine when children start school (3-4 years), is recommended to avoid vacc ...200818194631
[prevalence of genital hpv infection among women screened for cervical cancer].to assess the prevalence of high-risk genital human papillomavirus (hpv) infection by age group and risk factors associated.200818200349
detection of cervical human papillomavirus infection in filter paper samples: a comparative study. 200818201998
the p53 r72p polymorphism does not influence cervical cancer development in a portuguese population: a study in exfoliated cervical cells.the interaction between the e6 protein of the high-risk human papillomaviruses (hpvs) with p53 seems to be crucial in cervical carcinogenesis. the presence of arg/arg genotype at codon 72 of tp53 gene was characterized as a risk factor in development of cervical cancer. however, the role of this polymorphism remains controversial and some authors suggested that the origin of dna (blood or exfoliated cervical cells) might influence these results. this study analyzed the effect of the p53 codon 72 ...200818205229
tgf-beta1 and il-4 downregulate human papillomavirus-16 oncogene expression but have differential effects on the malignant phenotype of cervical carcinoma cells.host immune response to human papillomavirus (hpv) is a crucial factor in viral clearance and control of persistent infections. the existence of an intercellular control mechanism mediated by cytokines to suppress hpv-gene transcription and to prevent malignant conversion of hpv-infected cells, has been postulated. in a previous study, we demonstrated the inhibitory activity of several cytokines on the hpv-16 long control region (lcr)-driven transcription; among these, il-4 was reported as a lcr ...200818206261
interferon-gamma (ifn-gamma): a possible prognostic marker for clearance of high-risk human papillomavirus (hpv).the goal of this study was to identify cytokines that may predict high-risk hpv clearance or persistence in untreated patients with mild dysplasia or less of the uterine cervix.200818164379
type-dependent integration frequency of human papillomavirus genomes in cervical lesions.chromosomal integration of high-risk human papillomavirus (hr-hpv) genomes is believed to represent a significant event in the pathogenesis of cervical cancer associated with progression from preneoplastic lesions to invasive carcinomas. this hypothesis is based on experimental data suggesting that integration-dependent disruption of hr-hpv e2 gene functions is important to achieve neoplastic transformation and on clinical data gathered by analyzing lesions induced by human papillomavirus (hpv) ...200818172324
vaccinating adolescents in high-risk settings: lessons learned from experiences with hepatitis b vaccine.meeting the health needs of adolescents who live in high-risk settings such as homeless shelters, migrant camps, juvenile detention centers, prisons, and other types of residential facilities presents many challenges. although there is no doubt that adolescents in many high-risk settings are at increased risk for hepatitis b and human papillomavirus, acute medical and psychological problems may consume all of the provider's time and resources. potential health threats such as vaccine-preventable ...200818174322
projected cost-effectiveness of new vaccines for adolescents in the united states.economic assessments that guide policy making on immunizations are becoming increasingly important in light of new and anticipated vaccines for adolescents. however, important considerations that limit the utility of these assessments, such as the diversity of approaches used, are often overlooked and should be better understood.200818174323
time course of juvenile onset recurrent respiratory papillomatosis caused by human papillomavirus.with the recent licensure of a new quadrivalent vaccine, many diseases caused by human papillomavirus (hpv) can now be prevented, including recurrent respiratory papillomatosis (rrp). the purpose of this study was to describe the burden and time course of juvenile onset rrp.200818174855
risk assessment to guide the prevention of cervical cancer.advances in screening and diagnosis make it increasingly possible to prevent cervical cancer. however, if misused or poorly understood, these new tools will only increase costs and potentially harm patients without benefit. as a framework for standardized care that maximizes patient safety and well-being, we propose that a risk model be adopted to guide clinical management now and in the future. the model would use thresholds of increasing risk for cervical precancer and treatable cancer to guid ...200818162804
patterns of genotype distribution in multiple human papillomavirus infections.the relationship between severe-grade cervical lesions and clusters of human papillomavirus (hpv) genotypes in a taxonomic classification was surveyed in 232 women with previous abnormal cytology. hpv co-infections were clustered according to phylogenetic criteria. multiple infections were detected in 22.0% of the entire sample. clade a10 (represented by hpv-6 and hpv-11) appeared more frequently in multiple infections than clade a9, which was represented by five of the most common high-risk typ ...200818154550
longitudinal cytological follow-up of patients with a papanicolaou test interpretation of "atypical squamous cells of undetermined significance" that was followed by a negative reflex test for high-risk human papillomavirus types.the 2001 consensus guidelines essentially equated the follow-up management of patients with a papanicolaou (pap) test interpretation of negative for intraepithelial lesion or malignancy and those with an interpretation of atypical squamous cells of undetermined significance (asc-us) that was followed by a negative reflex test for high-risk human papillomavirus (hr hpv) types: follow-up cytology in 12 months. as several years have elapsed since these guidelines attained some measure of widespread ...200818156984
infrared coagulator treatment of high-grade anal dysplasia in hiv-infected individuals: an aids malignancy consortium pilot study.to evaluate prospectively the safety of the infrared coagulator (irc) as a treatment for anal high-grade squamous intraepithelial lesions (hsils) in hiv-infected individuals and to seek preliminary evidence for efficacy.200818156992
reactivity pattern of 92 monoclonal antibodies with 15 human papillomavirus types.most anti-human papillomavirus (hpv) capsid antibody assays are based on virus-like particles (vlp). we evaluated glutathione s-transferase (gst)-l1 fusion proteins as elisa antigens for determining type specificity and cross-reactivity of 92 vlp-specific monoclonal antibodies (mab) generated against nine mucosal alpha papillomavirus types of species 7, 9 and 10. the antibody panel included 25 new mab, and 24 previously published mab are further characterized. we determined the cross-reactivity ...200818089735
clinical cancer advances 2007: major research advances in cancer treatment, prevention, and screening--a report from the american society of clinical oncology.a message from asco's president: for the third year, the american society of clinical oncology (asco) is publishing clinical cancer advances: major research advances in cancer treatment, prevention, and screening, an annual review of the most significant cancer research presented or published over the past year. asco publishes this report to demonstrate the important progress being made on the front lines of clinical cancer research today. the report is intended to give all those with an interes ...200818086794
comprehensive comparison of the interaction of the e2 master regulator with its cognate target dna sites in 73 human papillomavirus types by sequence statistics.mucosal human papillomaviruses (hpvs) are etiological agents of oral, anal and genital cancer. properties of high- and low-risk hpv types cannot be reduced to discrete molecular traits. the e2 protein regulates viral replication and transcription through a finely tuned interaction with four sites at the upstream regulatory region of the genome. a computational study of the e2-dna interaction in all 73 types within the alpha papillomavirus genus, including all known mucosal types, indicates that ...200818084026
[vaccination against human papillomavirus. an new prevention strategy against cancer]. 200818081051
gene expression profiling to identify markers associated with deregulated htert in hpv-transformed keratinocytes and cervical cancer.although high-risk human papillomavirus (hpv) infection plays a major role in the development of cervical cancer, additive oncogenic events are involved as well. one key event involves increased activity of telomerase resulting from a deregulated expression of its catalytic subunit htert. our previous microcell-mediated chromosome transfer studies revealed that introduction of human chromosome 6 in the hpv16-immortalized keratinocyte cell line fk16a and in the hpv16-containing cervical cancer ce ...200817960611
a novel splice donor site at nt 1534 is required for long-term maintenance of hpv31 genomes.human papillomaviruses (hpv) are small double-stranded dna viruses that replicate as low copy number nuclear plasmids during the persistent phase. hpv only possess nine open reading frames but extend their coding capabilities by alternative rna splicing. we have identified in cell lines with replicating hpv31 genomes viral transcripts that connect the novel splice donor (sd) sites at nt 1426 and 1534 within the e1 replication gene to known splice acceptors at nt 3295 or 3332 within the e2/e4 reg ...200817904182
hpv e6 degradation of p53 and pdz containing substrates in an e6ap null background.human papillomavirus (hpv) type 16 and 18 e6 proteins target many of their cellular substrates for proteasome-mediated degradation. in the case of p53, this is mediated by the e6ap ubiquitin ligase. however it is still unclear whether other e6 substrates, in particular those containing pdz domains, are also degraded in a similar manner. to investigate this, we established an epithelial cell line from e6ap-null mice and used these cells as a background to perform e6-mediated in vivo degradation a ...200817934525
human papilloma virus specific t cells infiltrating cervical cancer and draining lymph nodes show remarkably frequent use of hla-dq and -dp as a restriction element.human papillomavirus (hpv)-induced malignancies are frequently infiltrated by lymphocytes. to comprehend the contribution of hpv-specific t cells in this anti-tumor response we developed a method that allowed the analysis of the presence and specificity of cervix-infiltrating and draining lymph node resident t cells in a group of 74 patients with cervical malignancies, 54 of which were induced by hpv16 or hpv18. we detected the presence of hpv16 or hpv18-specific t cells in at least 23 of the 54 ...200817955486
p53 codon 72 polymorphism and the risk of esophageal squamous cell carcinoma.the polymorphisms of the tumor suppressor gene p53 have been extensively investigated in numerous malignant tumors, particularly carcinomas associated with human papillomavirus (hpv) infection. however, the results remain controversial. to address a potential correlation between the p53 genotypes and the risk of esophageal squamous cell carcinoma (escc), we investigated the p53 codon 72 polymorphism in 435 patients with escc and 550 cancer-free subjects from the same geographical region. p53 arg ...200817918207
abnormal anal cytology in high-risk human papilloma virus infection in hiv-infected australians.to assess the prevalence of abnormal anal cytology and high-risk human papilloma virus (hpv)-type infection in hiv-infected people with a cd4 cell count >300 cells/microl.200817881414
human papillomavirus (hpv) genotype distribution in invasive cervical cancers in france: edith study.invasive cervical cancer (icc) remains a significant cause of morbidity and mortality in france. since human papillomavirus (hpv) is the necessary cause of icc, the aim of this study was to assess the type-specific prevalence of hpv in icc in france in order to locally evaluate the potential benefit of an hpv 16/18 l1 virus-like particles (vlp) vaccination. a total of 516 histological specimens collected in 15 centers were analyzed. among them, 86% had a diagnosis of squamous cell carcinoma (scc ...200817893882
high-risk human papillomavirus is present in cytologically false-negative smears: an analysis of "normal" smears preceding cin2/3.cervical screening, currently performed by cervical cytology, depends on the timely detection of malignant lesions for its success. the presence of high-risk human papillomavirus (hrhpv) is associated with an increased risk of subsequent high-grade cervical intra-epithelial neoplasia (cin2/3) and cervical cancer. the aim of this study was to determine the extent to which hrhpv is present in cervical smears with a high a priori chance of being false negative (ie, in normal smears preceding cin2/3 ...200817675539
evaluation of two types of sponges used to collect cervical secretions and assessment of antibody extraction protocols for recovery of neutralizing anti-human papillomavirus type 16 antibodies.immunogenicity evaluations in human papillomavirus (hpv) vaccine trials have relied on serological samples, yet cervical antibodies are likely to be most relevant for protection against infection. in order to assess functional antibody levels at the cervix, the secreted-alkaline-phosphatase neutralization assay (seapna) was used to measure hpv-neutralizing activity. we assessed the variability of the seapna with serum samples after vaccination with an hpv type 16 (hpv16) l1 virus-like particle v ...200818032596
oral contraceptives and clinical recurrence of human papillomavirus lesions and cervical intraepithelial neoplasia following treatment.to evaluate the effect of oral contraceptive use on the recurrence rate of human papillomavirus (hpv) lesions and cervical intraepithelial neoplasia (cin) following ablative or excisional procedures in a long-term follow-up.200818001738
langerhans cells and dendritic cells are cytotoxic towards hpv16 e6 and e7 expressing target cells.dendritic cells (dc) can be cytotoxic towards tumor cells by means of tnf family molecules expressed on the cell surface of activated dcs. tumor cells expressing appropriate receptors are killed by dc, generating a source of antigen to be presented to the immune system. it has not been investigated whether langerhans cells (lc) are selectively cytotoxic to tumor cells. this is of particular interest for epithelial tumor cells that physically interact with lc in vivo. among epithelial tumors, the ...200818004565
cervical human papillomavirus (hpv) infection in south african women: implications for hpv screening and vaccine strategies.the prevalence of cervical human papillomavirus (hpv) in south african women (n = 1,073) increased from 20.4% (173/848) in women with normal cytology to 41.7% (48/115) in women with atypical squamous cells of undetermined significance, 70.2% (40/57) in women with low-grade squamous intraepithelial lesions, and 83% (44/53) in women with high-grade squamous intraepithelial lesions (hsils). hpv types 16 and 35 were the dominant types in women with hsils but not in women in the other categories.200817977997
determination of cytokine protein levels in cervical mucus samples from young women by a multiplex immunoassay method and assessment of correlates.cytokines in cervical mucus are likely to play important roles in controlling pathogens. the cervical mucosal environment is complex, however, with many endogenous and exogenous factors that may affect cytokine levels. we used a multiplex, suspension-array-based immunoassay method to measure 10 proinflammatory (interleukin-1beta [il-1beta], il-6, and il-8) and immunoregulatory (gamma interferon [ifn-gamma], il-2, il-4, il-5, il-10, il-12, and il-13) cytokines in cervical mucus specimens collecte ...200817978011
e6 and e7 oncogene expression by human papilloma virus (hpv) and the aggressive behavior of recurrent laryngeal papillomatosis (rlp).recurrent laryngeal papillomatosis (rlp), a chronic disease associated with human papilloma virus (hpv), requires serial surgical procedures for debulking, resulting in debilitating long-term dysphonia, laryngeal scarring, and rarely malignant degeneration. human papilloma virus 11 tumors have been widely accepted as more aggressive than hpv 6 tumors; however, the clinical course has been difficult to predict at disease onset, and the biologic mediators of proliferation have not been well charac ...200817990904
epidemiology of human papillomavirus infection among fishermen along lake victoria shore in the kisumu district, kenya.the epidemiology of human papillomavirus (hpv) infection in men in kenya is largely uncharacterized. we set out to determine the prevalence and determinants of hpv infection among sexually active fishermen along lake victoria in the kisumu district of kenya.200817991686
[to screen or to prevent cervical carcinoma?]. 200818068908
rna interference against hpv16 e7 oncogene leads to viral e6 and e7 suppression in cervical cancer cells and apoptosis via upregulation of rb and p53.the simultaneous expression of human papillomavirus type 16 (hpv16) e6 and e7 oncogenes is pivotal for malignant transformation and maintenance of malignant phenotypes. silencing these oncogenes is considered to be applicable in molecular therapies of human cervical cancer. however, it remains to be determined whether hpv16 e6 and e7 could be both silenced to obtain most efficient antitumor activity by using rna interference (rnai) technology. herein, we designed a small interfering rna (sirna) ...200818060502
members of the human papillomavirus type 18 family (alpha-7 species) share a common association with adenocarcinoma of the cervix. 200818059025
inhibition of hpv-16 l1 expression from l1 cdnas correlates with the presence of hnrnp a1 binding sites in the l1 coding region.the human papillomavirus type 16 (hpv-16) l1 capsid protein is very poorly expressed from cdna expression plasmids transiently transfected into mammalian cells. the results described herein demonstrate that inhibition of hpv-16 l1 expression from l1 cdnas correlates with the presence of splicing regulatory sequences in the l1 coding region. this inhibitory effect correlates with the binding of hnrnp a1 to the rna elements. similar to unutilised splice sites that may retain mrnas in the nucleus, ...200818040766
the regulatory element in the 3'-untranslated region of human papillomavirus 16 inhibits expression by binding cug-binding protein 1.the 3'-untranslated regions (utrs) of human papillomavirus 16 (hpv16) and bovine papillomavirus 1 (bpv1) contain a negative regulatory element (nre) that inhibits viral late gene expression. the bpv1 nre consists of a single 9-nucleotide (nt) u1 small nuclear ribonucleoprotein (snrnp) base pairing site (herein called a u1 binding site) that via u1 snrnp binding leads to inhibition of the late poly(a) site. the 79-nt hpv16 nre is far more complicated, consisting of 4 overlapping very weak u1 bind ...200818042543
tonsil t cell immunity to human papillomavirus in the absence of detectable virus in healthy adults.human papillomavirus (hpv) is known to infect the epithelium of the upper aerodigestive tract; however, major questions regarding prevalence and persistence of infection, and their relation to local immune response, remain unanswered.200818043489
recurrent respiratory papillomatosis: an overview of current thinking and treatment.human papillomaviruses (hpv) infection in benign laryngeal papillomas is well established. the vast majority of recurrent respiratory papillomatosis lesions are due to hpv types 6 and 11. human papillomaviruses are small non-enveloped viruses (>8 kb), that replicate within the nuclei of infected host cells. infected host basal cell keratinocytes and papillomas arise from the disordered proliferation of these differentiating keratinocytes. surgical debulking of papillomas is currently the treatme ...200818046565
comparison of amplicor and hybrid capture ii assays for high risk hpv detection in normal and abnormal liquid-based cytology: use of inno-lipa genotyping assay to screen the discordant results.the study was aimed to evaluate the feasibility of detecting human papillomavirus (hpv) in women with normal or abnormal cervical smears using the roche amplicor mwp hpv test. we compared by amplicor test and hybrid capture ii (hcii) test, the prevalence of hr-hpv in 470 cervical samples including 55 samples with wnl cytology, 208 asc-us, 193 lgsil and 14 hgsil. samples with discordant results were retested with inno-lipa genotyping hpv test v2. the hr-hpv positivity in wnl cytology samples was ...200818036888
molecular techniques in cytopathology practice.in the last decade, new molecular techniques were introduced into pathology laboratories. cytology also benefited from the innovations emerging from this new era. molecular cytopathology (mcp) can be defined as molecular studies applied on all types of cytological specimens, namely gynaecology cytology, exfoliative non- gynaecology cytology and fine needle aspirates. the development of many new ancillary techniques has paralleled the emergence of clinical cytology as a major diagnostic specialty ...200818037664
hpv typing in women with cervical precancerous and cancerous lesions in northwestern iran.the role of human papillomavirus (hpv) in the etiology of cervical cancer is now well established. this investigation was designed to study the prevalence of the four most common high-risk hpvs in the archival tissues with precancerous and cancerous lesions from patients from northwestern iran.200818500169
human papillomavirus genotyping for the eight oncogenic types can improve specificity of hpv testing in women with mildly abnormal pap results.to evaluate whether human papillomavirus (hpv) genotyping for the selected oncogenic hpv types can improve the efficacy of hpv dna testing in predicting cervical intraepithelial neoplasia (cin 2/3) in women with mildly abnormal pap results, we compared hpv dna testing and hpv genotyping for eight oncogenic types (16, 18, 31, 33, 35, 45, 52 and 58) in pap specimens with abnormal results (hsil, 20 cases; lsil, 42 cases; asc-us, 94 cases) and follow-up biopsies. using consensus primer-mediated pcr ...200818500260
association of genetic polymorphism of the dna base excision repair gene (ape-1 asp/148 glu) and hpv type (16/18) with the risk of cervix cancer in north indian population.cervical cancer is one of the most common neoplastic diseases affecting women, with a combined world wide incidence of almost half a million new cases. reduced dna repair capacity (drc) can render a high risk of developing many types of cancer; including cervical cancer. polymorphisms in dna repair genes may contribute the genetic instability and carcinogenesis. smoking experience and use of oral contraceptives have been confirmed to be risk factors for cervical cancer. the purpose of the presen ...200818503157
the epidemiological and economic impact of a quadrivalent human papillomavirus vaccine (6/11/16/18) in the uk.to assess the potential epidemiological and economic impact of a prophylactic quadrivalent human papillomavirus (hpv) (6/11/16/18) vaccine for preventing cervical cancer, cervical intraepithelial neoplasia grades 2 and 3 (cin2/3), cin1 and genital warts.200818503574
bowen's disease of the penis treated with topical imiquimod 5% cream.bowen's disease of the penis is relatively uncommon, but the prevalence has increased in recent years. risk factors for penile squamous cell cancer include smoking, infection with human papilloma virus (hpv), immunosuppression, and a history of conditions such as balanitis, phimosis, and lichen sclerosis et atrophicus. bowen's disease of the penis is often managed by local excision of the lesion. less invasive methods are now employed more frequently and include laser ablation, electrodessicatio ...200818505144
preferences for human papillomavirus testing with routine cervical cancer screening in diverse older women.human papillomavirus (hpv) testing is increasingly being used to determine the optimal cervical cancer screening interval in older women. little is known about women's attitudes toward hpv testing or how these attitudes may influence medical discussions about cervical cancer screening.200818506546
[laryngeal intraepithelial neoplasia].precancer (carcinoma in situ) or laryngeal intraepithelial neoplasia (lin) is a non-invasive lesion that has genetic abnormalities, loss of cellular control functions, and some phenotypic characteristics of invasive cancer and that predicts for a substantial likelihood of developing invasive cancer. several classifications have been proposed but none has received a total agreement. with regard to diagnosis, treatment and prognosis, these lesions differ substantially from infiltrating carcinoma. ...200818506655
possible role of human papilloma virus infection in response to neoadjuvant therapy in patients with esophageal cancer.human papilloma virus (hpv) infection in esophageal cancer cases has been found in 0-70%, depending on different methods and geographical variances. complete pathological response has been found in 30% of cases after neoadjuvant chemo-radiation (crx). the aim of this study was to discover a possible relation between hpv-infection and response.200818507085
a review of the evidence comparing the human papillomavirus vaccine versus condoms in the prevention of human papillomavirus infections.to examine the evidence related to the efficacy of condom use versus the human papillomavirus vaccine in the prevention of human papillomavirus infections.200818507603
epidermodysplasia verruciformis-associated and genital-mucosal high-risk human papillomavirus dna are prevalent in nevus sebaceus of jadassohn.the hamartoma nevus sebaceus (ns) presents at birth or early childhood as a yellowish plaque characterized histologically by variable acanthosis, papillomatosis, sebaceus hyperplasia, and proliferations of adnexal structures. clinically apparent human papillomavirus (hpv) infection is also recognized by acanthosis and papillomatosis.200818638629
tobacco smoking and risk of recurrence for squamous cell cancer of the anus.squamous cell cancer of the anus is associated with multiple risk factors, including infection with human papillomavirus, immunosuppression, chronic inflammation, and tobacco smoking, although there is little data on these factors for the prediction of recurrent disease. here, we evaluated the risk of recurrence and mortality of anal carcinoma in association with tobacco smoking.200818639388
cervical cancer screening following prophylactic human papillomavirus vaccination.the recognition that infection with certain human papillomavirus (hpv) types is a necessary cause of cervical cancer has opened new fronts for the prevention of this disease. primary prevention is now possible via immunization with highly efficacious hpv vaccines and secondary prevention has gained impetus with the advent of sensitive hpv dna testing to improve traditional pap cytology screening programs. although universal vaccination of teenagers and young women is a desirable policy cost rema ...200818642468
human papilloma virus: diagnostic, treatment and preventive issues.human papilloma virus (hpv), a sexually transmitted virus, is usually found in the genital tract and causes various lesions at the mucosae of both men and women. it is considered as a causative factor of cervical cancer even if all women infected by hpv will not develop the disease. this article reviews diagnostic aspects and therapeutic alternatives for the treatment of hpv infected females, as well as aspects concerning the prophylactic hpv vaccines.200818642576
evaluation of high-risk human papillomaviruses type distribution in cervical cancer in sichuan province of china.infection with high-risk human papillomavirus is an important factor associated with cervical cancer, and the distribution of hpv types varies greatly worldwide. determination of type-specific hpv prevalence constitutes an important step towards the development of vaccines for the prevention of cervical cancer.200818644159
diffuse intranasal papillomatosis and its association with human papillomavirus. 200818645131
hpv16 and bpv1 infection can be blocked by the dynamin inhibitor dynasore.the initial entry of papillomaviruses into their target cells has been shown to occur by clathrin-mediated endocytosis and caveolae-mediated endocytosis. these mechanisms entail the formation of nascent-coated vesicles at the plasma membrane. such coated vesicles, clathrin or caveolin, form and pinch-off in a controlled mechanism that involves several proteins including dynamin. dynamin is a gtpase that forms a dynamin ring at the stem connecting the nascent vesicle to the plasma membrane. in a ...200818645330
[cost effectiveness of human papilloma virus testing in cervical cancer screening: a literature review].human papilloma virus dna testing may improve the cost effectiveness of cervical cancer screening programs. however, the circumstances to get this improvement are not the same between countries. the objective of this paper is to evaluate the cost effectiveness of introducing human papilloma virus testing in the current screening practice both in developed and developing countries. we conducted a review of published articles since january 2000 until december 2006 related to the cost effectiveness ...200818645671
high-risk human papillomavirus infections in breast cancer in syrian women and their association with id-1 expression: a tissue microarray study.high-risk human papillomaviruses (hpvs) could be important risk factors for breast carcinogenesis and metastasis. based on this hypothesis, we recently studied the effect of e6/e7 onco-proteins of high-risk hpv type 16 in two non-invasive human breast cancer cell lines, bt20 and mcf7; we reported that e6/e7 converts these cell lines to invasive cells. this is accompanied by an overexpression of id-1, which is an important regulator of breast metastasis. in this investigation, we examined the pre ...200818648363
human papillomavirus detected in female breast carcinomas in japan.to investigate the aetiological role of human papillomavirus (hpv) in breast cancer, we examined the presence, genotype, viral load, and physical status of hpv in 124 japanese female patients with breast carcinoma. human papillomavirus presence was examined by pcr using spf10 primers, and primer sets targeting the e6 region of hpv-16, -18, and -33. the inno-lipa hpv genotyping kit was used to determine genotype. human papillomavirus dna was detected in 26 (21%) breast carcinomas. the most freque ...200818648364
effective induction of type 1 helper igg2a and cytotoxic t-cell responses in mice following immunization with human papillomavirus type 16 e2 in mf59.human papillomavirus (hpv) 16 e2-specific cell-mediated immunity to the early viral antigen e2 is associated with regression of natural infection in patients with cervical dysplasia. vaccination strategies that activate this type of immune response may have application in the immunotherapeutic treatment of pre-existing hpv infections. the objective of this study was to test if cell-mediated immunity to e2 could be activated when delivered with the already licensed adjuvant mf 59. we found that i ...200818476769
the physical state of hpv16 infection and its clinical significance in cancer precursor lesion and cervical carcinoma.integration of high-risk human papillomavirus (hr-hpvs) into the host dna has been proposed as a risk for cervical carcinogenesis. hpv-16 is the predominant high-risk type and its integration ration varied largely in different cervical cancer (cc) samples. the aim of this study was to evaluate the correlation between physical state of hpv16 infection and extent of cervical lesion, as well as the clinical significance of virus existing state.200818478264
human papillomavirus types 16 and 18 vaccine (recombinant, as04 adjuvanted, adsorbed) [cervarix]: profile report. 200818481902
age considerations when vaccinating against hpv.human papillomavirus (hpv) vaccines have been shown to be both highly effective and safe, and there is now considerable enthusiasm among healthcare providers to use the vaccines to reduce the burden of hpv-associated disease in women. when considering who should be vaccinated, it is important that providers understand the complex relationships between age and hpv infections. hpv infections and cervical cancer have a widespread impact on society. cervical cancer is the cause of a significant amou ...200818482558
invited commentary: is monitoring of human papillomavirus infection for viral persistence ready for use in cervical cancer screening?persistent cervical infections by approximately 15 carcinogenic genotypes of human papillomavirus (hpv) cause virtually all cases of cervical cancer and its immediate precancerous precursor, cervical intraepithelial neoplasia grade 3 or carcinoma in situ. as is shown in a meta-analysis by koshiol et al. (am j epidemiol 2008;168:123-137), detection of carcinogenic hpv viral persistence could be used to identify women at the greatest risk of cervical precancer. specifically, women who have carcino ...200818483124
the human papillomavirus vaccine.dialogues in dermatology, a monthly audio program from the american academy of dermatology, contains discussions between dermatologists on timely topics. commentaries from dialogues editor-in-chief warren r. heymann, md, are provided after each discussion as a topic summary and are provided here as a special service to readers of the journal of the american academy of dermatology.200818485986
[frequency, persistence and recurrence of hpv lesions of the uterine cervix in hiv-seropositive women].the aim of this study was to determine the frequency, persistence and risk of recurrence of human papillomavirus (hpv) lesions of the uterine cervix in human immunodeficiency virus (hiv)-infected women.200818486518
alterations in the p53 pathway and their association with radio- and chemosensitivity in head and neck squamous cell carcinoma.chemotherapy and/or radiotherapy are established measures in treatment protocols of head and neck squamous cell carcinoma (hnscc). however, we still lack reliable predictive markers for the response to radio- and chemotherapy. the p53 pathway is involved in stress response and thus might influence chemo-/radiosensitivity. using 29 hnscc cell lines previously characterized for p53 mutations, we simultaneously analyzed several key players in the p53 pathway by rt-pcr, transcript sequencing and imm ...200818487078
md simulations of papillomavirus dna-e2 protein complexes hints at a protein structural code for dna deformation.the structural dynamics of the dna binding domains of the human papillomavirus strain 16 and the bovine papillomavirus strain 1, complexed with their dna targets, has been investigated by modeling, molecular dynamics simulations, and nuclear magnetic resonance analysis. the simulations underline different dynamical features of the protein scaffolds and a different mechanical interaction of the two proteins with dna. the two protein structures, although very similar, show differences in the relat ...200818487311
the hpv vaccine: framing the arguments for and against mandatory vaccination of all middle school girls.human papillomavirus (hpv), the virus responsible for cervical cancer, is the most common viral sexually transmitted infection in the united states. a vaccine was approved in 2006 that is effective in preventing the types of hpv responsible for 70% of cervical cancers and 90% of genital warts. proposals for routine and mandatory hpv vaccination of girls have become sources of controversy for parents of school-aged youth, legislators, members of the medical community, and the public at large.200818489462
reductions in human papillomavirus-disease resource use and costs with quadrivalent human papillomavirus (types 6, 11, 16, and 18) recombinant vaccination: the future study economic evaluation.to examine the short-term impact of quadrivalent human papillomavirus (hpv) (types 6/11/16/18) recombinant vaccination upon hpv disease-related health-care resource utilization and costs among young women.200818489503
incidental epidermodysplasia verruciformis human papillomavirus infection (ev acanthoma): evidence for 'field cancerization' and a putative cofactor in seborrheic keratosis. 200818494819
centrosome-mediated chromosomal instability and steroid hormones as co factors in human papillomavirus-associated cervical carcinogenesis: small viruses help to answer big questions. 200818497035
human papillomavirus vaccine: effect of ethnic group should be clarified. 200818497381
long-term outcome after combined radiochemotherapy for anal cancer - retrospective analysis of efficacy, prognostic factors, and toxicity.this retrospective study evaluated the efficacy, prognostic factors, and toxicity of combined radiochemotherapy for anal cancer.200818497514
mandating a human papillomavirus vaccine: an investigation into whether such legislation is constitutional and prudent. 200818512537
hscrib, a human homologue of drosophila neoplastic tumor suppressor, is a novel death substrate targeted by caspase during the process of apoptosis.hscrib, human homologue of drosophila neoplastic tumor suppressor, was identified as a target of human papillomavirus e6 oncoprotein for the ubiquitin-mediated degradation. here, we report that hscrib is a novel death substrate targeted by caspase. full-length hscrib was cleaved by caspase during death ligands-induced apoptosis, which generates a p170 c-terminal fragments in hela cells. in vitro cleavage assay using recombinant caspases showed that hscrib is cleaved by the executioner caspases. ...200818513328
the e6e7 oncoproteins of cutaneous human papillomavirus type 38 interfere with the interferon pathway.non-melanoma skin cancer is the most frequent malignancy in caucasian populations. evidence suggests the involvement of cutaneous human papillomavirus (hpv) of the genus beta (beta) in this disease. the ability of e6 and e7 of mucosal hpv to promote cellular transformation and inhibit immune response-related pathways plays a key role in cervical carcinogenesis. beta hpv-38 e6 and e7 display transforming activities in in vitro and in vivo models, but their impact on immune surveillance is unknown ...200818519144
ctl responses to a dna vaccine encoding e7 gene of human papillomavirus type 16 from an iranian isolate.cervical cancer is the most prevalent tumor in developing countries and the second most frequent cancer among female population worldwide. specific human papillomaviruses and, most notably, hpv types 16 and 18 are recognized as being causally associated with cervical carcinomas. the early hpv type 16 genes, e6 and e7, directly participate in the in vitro transformation of primary human keratinocytes and represent an excellent target for immune therapy of hpv related disease.200818523353
incidence and risk factors for verrucae in women.to describe the incidence and risk factors for verrucae in hiv-infected and uninfected women.200818525267
hpv types present in invasive cervical cancers of hiv-seropositive women. 200818537158
quantitation of human papillomavirus type 16 e6 oncogene sequences by real-time or quantitative pcr with evagreen.quantitation of e6 oncogene sequences of the human papillomavirus type 16 by real-time or quantitative pcr (qpcr) is used to determine the viral load, which correlates with the degree of the cervical neoplastic lesions. in the presence of evagreen, a new dna intercalating fluorochrome, we obtained consistent and reproducible qpcr amplification curves and thermal denaturation profiles identical to those of the authentic e6-hpv16 (human papillomavirus 16) genome from the amplification products der ...200818539127
value of combining hpv-dna testing with follow-up papanicolaou smear in patients with prior atypical squamous cells of undetermined significance.to address human papillomavirus (hpv) testing on negative pap tests preceded by atypical squamous cells of undetermined significance (asc-us) without reflex hpv testing.200818540292
significance of shp-1 and shp-2 expression in human papillomavirus infected condyloma acuminatum and cervical cancer.human papillomaviruses (hpvs) are a group of dna viruses that infect the skin and mucous membranes. type hpv6/11 is closely related to condyloma acuminatum, while hpv16/18 is the principal cause of cervical cancer. in this study, we examined the expression of protein tyrosine phosphatases shp-1 and shp-2 in condyloma acuminatum, cervical cancer and the relationship between shp-1/shp2 expression and hpv infection. forty condyloma acuminatum cases, 20 cervical cancer cases and 20 normal human fore ...200818543080
update on molecular diagnostic tests in head and neck cancer.head and neck cancers (hncs) include several cancers originating in the upper airways that represent a variety of histologies. the most common type of hnc is squamous cell carcinoma (scc), which is linked to tobacco and alcohol use and to human papilloma virus (hpv). at present, there are no standard molecular tests that are routinely used in clinics. this overview will discuss the current knowledge on molecular markers with the potential to be developed as diagnostic tests for cancer risk asses ...200818544435
urinary bladder, urethral and renal condylomata, due to human papilloma virus (hpv) type 11 associated with transitional cell tumors in bladder, ureter and kidney: a case report. 200818547990
exposure profiles and human papillomavirus infection in skin cancer: an analysis of 25 genus beta-types in a population-based study.an increasing number of studies report that genus beta human papillomaviruses (hpvs) are associated with skin cancer, with suggestions of specificity for squamous cell carcinoma (scc) of the skin. we have conducted a systematic examination of hpv dna in tumors from immunocompetent hosts, including scc and basal cell carcinoma (bcc), using a highly sensitive methodology and population-based samples to test the hypothesis that a differential prevalence of beta-hpvs exists between scc (n=101) and b ...200818548109
human papillomavirus e6/e7 oncogenes promote mouse ear regeneration by increasing the rate of wound re-epithelization and epidermal growth.mammals have limited regeneration capacity. we report here that, in transgenic mice (tg(bk6-e6/e7)), the expression of the e6/e7 oncogenes of human papilloma virus type 16 (hpv16) under the control of the bovine keratin 6 promoter markedly improves the mouse's capacity to repair portions of the ear after being wounded. increased repair capacity correlates with an increased number of epidermal proliferating cells. in concordance with the expected effects of the e6 and e7 oncogenes, levels of p53 ...200818548112
[advisory report from the health council of the netherlands to include human papillomavirus vaccination in the national immunisation programme for the prevention of cervical cancer].the health council of the netherlands has advised the minister of health, welfare and sport to include vaccination against human papillomavirus (hpv) for girls aged 12 years as part of the national immunisation programme. a catch-up vaccination is proposed for girls aged 13-16 years. high-risk hpv infections cause cervical cancer. approximately 70% of these infections are attributed to hpv-16 and hpv-18. vaccination was shown to prevent these infections and subsequent precursor lesions. its effi ...200818549170
[flat penile lesions in the sexual transmission of human papillomavirus].--infection with high-risk genital human papillomavirus (hrhpv) is necessary for the development of cervical cancer and its early stages. --although it is widely accepted that infection with hrhpv is sexually transmitted, insight into the clinical manifestations of hrhpv infection in men is limited. --flat penile lesions may be the hrhpv reservoir in men. --their limited visibility with the naked eye explains why flat penile lesions may escape the attention of both the carrier and the clinician. ...200818549173
health and economic outcomes of hpv 16,18 vaccination in 72 gavi-eligible countries.the risk of dying from cervical cancer is disproportionately borne by women in developing countries. two new vaccines are highly effective in preventing hpv 16,18 infection, responsible for approximately 70% of cervical cancer, in girls not previously infected. the gavi alliance (gavi) provides technical assistance and financial support for immunization in the world's poorest countries. using population-based and epidemiologic data for 72 gavi-eligible countries we estimate averted cervical canc ...200818550229
evidence for benefits from treating cervical ectopy: literature review.uterine cervical ectopy (cervical erosion) is today considered to be a physiological condition, but there still seems to be a strong tendency towards treating it. the purpose of this study was to review the medical literature for evidence regarding benefits from treating cervical ectopy.200818553039
determinants of incidence and clearance of high-risk human papillomavirus infections in rural rakai, uganda.we used self-administered vaginal swabs to assess the incidence and clearance of carcinogenic human papillomavirus (hpv) infections in rural rakai, uganda.200818559545
influence of human papillomavirus type 16 (hpv-16) e2 polymorphism on quantification of hpv-16 episomal and integrated dna in cervicovaginal lavages from women with cervical intraepithelial neoplasia.integrated human papillomavirus type 16 (hpv-16) viral loads are currently estimated by quantification with real-time pcr of hpv-16 e6 (rt-e6 and hpv-16 pg) and e2 (rt-e2-1) dna. we assessed the influence of hpv-16 e2 polymorphism on quantification of integrated hpv-16 dna in anogenital specimens. hpv-16 e2 was sequenced from 135 isolates (123 from european and 12 from non-european lineages). an assay targeting conserved hpv-16 e2 sequences (rt-e2-2) was optimized and applied with rt-e6 and rt-e ...200818559943
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