Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| prognostic value of increased expression of raco-1 in patients with hepatitis b-related hepatocellular carcinoma. | ring domain ap-1 coactivator-1 (raco-1) is a coactivator that links c-jun to growth factor signaling and is essential for ap-1 function. this study aimed to investigate the expression and clinical significance of raco-1 protein in hepatitis b virus (hbv)-related hepatocellular carcinoma (hcc) in china. a total of 136 tissue samples of hbv-related hcc were detected by immunohistochemistry (including 76 patients in training cohort and 60 patients in validation cohort). correlation between raco-1 e ... | 2017 | 28243109 |
| nucleic acid-based polymers effective against hepatitis b virus infection in patients don't harbor immunostimulatory properties in primary isolated liver cells. | nucleic acid polymers (naps) block the release of subviral particles from hepatocytes, a mechanism consistent with their antiviral activity against hepatitis b virus (hbv) in patients. analysis of immunostimulatory properties of naps were conducted with several nap species: rep 2006, the prototypic degenerate nap [dn]40, containing tlr9-stimulatory cpg; rep 2055 a clinically active nap with a sequence [dadc]20 devoid of cpg content; rep 2139 (also clinically active) and rep 2165 (rep 2055 analog ... | 2017 | 28272460 |
| knowledge, attitude and behaviours towards recommended vaccinations among healthcare workers. | healthcare workers (hcws) are an important group of professionals exposed to biological risk during their work activities. so, the aim of this study is to perform a survey on the knowledge, attitude and behaviour of italian hcws towards the vaccinations recommended by the ministry of health. a cross-sectional study was carried out during the period september 2014-august 2015 in the lazio region. the study was conducted by recruiting hcws and biomedical students. the sample was comprised of 571 r ... | 2017 | 28272332 |
| [the potential use of serum hbv rna to guide the functional cure of chronic hepatitis b]. | hepatitis b virus (hbv) covalently closed circular dna (cccdna) in infected hepatocytes is the main cause of off-therapy viral rebound. the half-life of cccdna is only 33-50 days, so the conversion of newly synthesized rcdna to cccdna in the nucleus is essential for the maintenance of cccdna pool in infected hepatocytes. though not directly targeting the existing cccdna, current nucleos(t)ide analogues (nas) may exhaust the cccdna reservoir by blocking the rcdna formation. indeed, a prolonged co ... | 2017 | 28297795 |
| [research advances in diagnosis and treatment of liver failure in 2016]. | liver failure has various clinical types, a complex pathogenesis, and rapid disease progression, as well as a high mortality rate. liver failure caused by hepatitis b virus infection is the most common type in china with severe conditions, various complications, and a mortality rate as high as 40%-90%. invasive fungal disease secondary to acute-on-chronic liver failure can affect patients' prognosis and increase mortality rate. this article introduces the research advances in hepatitis b-related ... | 2017 | 28297793 |
| [advances in clinical research on rta181 mutation in hepatitis b virus]. | nowadays, nucleos(t)ide analogues (nas) are important drugs for the treatment of chronic hepatitis b and can suppress the virus through inhibiting the activity of hepatitis b virus (hbv) polymerase. however, rta181 mutation in hbv can reduce the sensitivity of hbv to various nas, which brings new challenges to antiviral therapy. this article briefly introduces the research advances in the clinical detection rate of rta181 mutation and its influence on therapeutic effect and prognosis. | 2017 | 28297788 |
| [risk factors for hospital-acquired infection in patients with liver cirrhosis and value of immuknow assay in monitoring immune cell function]. | 2017 | 28297778 | |
| genetic variation in the vitamin d pathway cyp2r1 gene predicts sustained hbeag seroconversion in chronic hepatitis b patients treated with pegylated interferon: a multicenter study. | evidence of a role of vitamin d in the immune system is increasing. low serum vitamin d is associated with increased hepatitis b virus replication. genome-wide association study (gwas) data has revealed a number of the single nucleotide polymorphisms (snps) within the vitamin d synthetic pathway that affect vitamin d functions. we aimed to determine the association between snps in the vitamin d gene cascade and response to pegylated interferon (pegifn) therapy in hepatitis b e-antigen (hbeag)-po ... | 2017 | 28296915 |
| ugt1a1*28 relationship with abnormal total bilirubin levels in chronic hepatitis c patients: outcomes from a case-control study. | gilbert syndrome (gs) is a frequent benign clinical condition, marked by intermittent unconjugated hyperbilirubinemia, mostly due to the polymorphism uridine diphosphate-glucuronosyltransferase 1a1*28 (ugt1a1*28). hyperbilirubinemia has been reported in a gs patient undergoing hepatitis c treatment, and other ugt isoforms polymorphisms have been linked to worse outcomes in viral hepatitis. yet, little is known to gs contributions' to the liver disease scenario. our aim was to assess ugt1a1 genot ... | 2017 | 28296739 |
| combination therapy with lamivudine and angiotensin-converting enzyme inhibitor/angiotensin receptor blocker for hepatitis b virus-associated glomerulonephritis with mild to moderate proteinuria: a clinical review of 38 cases. | the treatment of hbv-associated glomerulonephritis (hbv-gn) is still a challenge in clinical practice now. the objective of this study was to report the pathological characteristics of hbv-gn presenting with mild to moderate proteinuria and to evaluate the therapeutic efficacy of lamivudine (lam) in combination with angiotensin-converting enzyme inhibitor (acei)/angiotensin receptor blocker (arb) as compared to acei/arb monotherapy. | 2017 | 28283858 |
| serum hepatitis b core-related antigen is a satisfactory surrogate marker of intrahepatic covalently closed circular dna in chronic hepatitis b. | recently, hepatitis b core-related antigen (hbcrag) has been suggested as an additional marker of hepatitis b virus (hbv) infection. this study aimed to investigate whether serum quantitative hbcrag (qhbcrag) was a satisfactory surrogate marker of intrahepatic covalently closed circular dna (cccdna). a total of 139 patients with liver biopsy were enrolled, consisting of 59 patients in immune tolerance (it) phase, 52 patients in immune clearance (ic) phase, 18 patients in low-replication (lr) pha ... | 2017 | 28282964 |
| hepatitis b virus x protein stimulates proliferation, wound closure and inhibits apoptosis of huh-7 cells via cdc42. | chronic hepatitis b virus (hbv) infection has been considered as the major cause of hepatocellular carcinoma (hcc). hepatitis b virus x protein (hbx) has been reported to be oncogenic. the underlying mechanisms of hbv-related hcc are not fully understood, and the role played by the hbx protein in hbv induced carcinogenesis remains controversial. cdc42, a member of the rho gtpase family, has been reported to be overexpressed in several different cancers, including hbv-related hcc. however, the sp ... | 2017 | 28282856 |
| interleukin-23 mediates the pathogenesis of lps/galn-induced liver injury in mice. | interleukin-23 (il-23) is required for t helper 17 (th17) cell responses and il-17 production in hepatitis b virus infection. a previous study showed that the il-23/il-17 axis aggravates immune injury in patients with chronic hepatitis b virus infection. however, the role of il-23 in acute liver injury remains unclear. | 2017 | 28282579 |
| a novel colorimetric pcr-based biosensor for detection and quantification of hepatitis b virus. | hepatitis b virus (hbv) can cause viral infection that attacks the liver and it is a major global health problem that puts people at a high risk of death from cirrhosis of the liver and liver cancer. hbv has infected one-third of the worldwide population, and 350 million people suffer from chronic hbv infection. for these reasons, development of an accurate, sensitive, and expedient detection method for diagnosing, monitoring, and assessing therapeutic response of hbv is very necessary and urgen ... | 2017 | 28281267 |
| interrelationship of hepatitis c virus genotypes with patient characteristics in bahrain. | hepatitis c virus (hcv) shows genotype-based variation in prevalence across geographical regions. this study was conducted to understand the clinical interrelationship of hcv genotypes with patient characteristics. | 2017 | 28280398 |
| comparison of the long-term efficacy between entecavir and tenofovir in treatment- naïve chronic hepatitis b patients. | there have been limited studies directly comparing the long-term efficacy between entecavir (etv) and tenofovir disoproxil fumarate (tdf). this study was aimed to compare the long-term efficacy between them in treatment-naïve chronic hepatitis b (chb). | 2017 | 28279168 |
| polymorphisms in the il-17 gene (rs2275913 and rs763780) are associated with hepatitis b virus infection in the han chinese population. | interleukin-17 (il-17) can accelerate the release of many pro-inflammatory cytokines. the purpose of our study was to investigate the potential association between polymorphisms in the il-17 gene and susceptibility to hepatitis b virus (hbv) infection in the han chinese population. | 2017 | 28277785 |
| long-term persistence of immunity after hepatitis b vaccination: is this substantiated by the literature? | hepatitis b vaccination is held to provide life-long protection against hepatitis b virus (hbv) infection, but evidence for this notion remains wanting, since no studies have assessed the vaccinees in their fourth decade of life. indeed, there are several reports indicating that despite vaccination in infancy, the prevalence of hbv infection still increased with age in the vaccinees, and that both anti-hbs titer and anamnestic response declined with age. clearly it is time to clarify the long-te ... | 2017 | 28277087 |
| a pilot study of salivary n-glycome in hbv-induced chronic hepatitis, cirrhosis, and hepatocellular carcinoma. | hepatitis b is a potentially life-threatening liver infection caused by the hepatitis b virus (hbv), which can lead to chronic liver disease and put people at high risk of death from cirrhosis of the liver and liver cancer. however, little is known about the correlation of salivary n-linked glycans related to hbv-infected liver diseases. here we investigated n-linked glycome in saliva from 200 subjects (50 healthy volunteers (hv), 40 hbv-infected patients (hb), 50 cirrhosis patients (hc), and 60 ... | 2017 | 28389847 |
| assessing hepatitis b knowledge among immigrant communities in new york city. | the objective of this study was to assess the knowledge of hepatitis b virus (hbv) among new york city immigrants. data were obtained from cohort of 2385 persons at-risk for hbv, who completed a knowledge assessment survey during hbv screening events in 2010-2013. hbv knowledge scores were very low among the tested population, with the majority answering every question incorrectly. participants had higher odds of obtaining a better score if they were fluent in english or born in the us, where pa ... | 2017 | 28389832 |
| hbxip overexpression is correlated with the clinical features and survival outcome of ovarian cancer. | accumulated evidence has demonstrated that mammalian hepatitis b x-interacting protein (hbxip) has broad roles in cancer. although hbxip is associated with a variety of cancers, the hbxip protein expression level and its clinical significance in ovarian cancer have not yet been determined. the aim of this study is to investigate the association between hbxip expression and the clinicopathological features of ovarian cancer patients to determine whether hbxip may be correlated with a poor prognos ... | 2017 | 28388957 |
| high sero-prevalence of hepatitis b virus and human immunodeficiency virus infections among pregnant women attending antenatal clinic at temeke municipal health facilities, dar es salaam, tanzania: a cross sectional study. | hepatitis b virus (hbv) and human immunodeficiency virus (hiv) infection in pregnancy is associated with direct effect of pregnancy and potential viral transmission from mother to newborn. in tanzania very little in known on prevalence of hbv infection and their associated factors among pregnant women in lower health facilities. the main objective of the study was to determine the prevalence of hbsag, hiv and hbv-hiv co-infection among pregnant women attending antenatal clinics in dar es salaam. | 2017 | 28388879 |
| immune balance in hepatitis b infection: present and future therapies. | chronic hepatitis b virus (hbv) infection affects millions of people worldwide and about half a million people die every year. india represents the second largest pool of chronic hbv infections with an estimated 40 million chronically infected patients. persistence or clearance of hbv infection mainly depends upon host immune responses. chronically infected individuals remain in immune tolerant phase unless hbv flares and leads to development of chronic active hepatitis or acute on chronic liver ... | 2017 | 28387980 |
| inhibitory effects of resveratrol on hepatitis b virus x-protein (hbx)-induced hepatocellular carcinoma (hcc). | liver cancer occurs very frequently worldwide and hepatocellular carcinoma (hcc) accounts for more than 80% of total primary liver cancer cases. here, the anticarcinogenic effects of resveratrol against hepatitis b virus (hbv)-induced hcc were investigated using hbv x-protein-overexpressing huh7 (huh7-hbx) human hepatoma cells. mtt assay showed that resveratrol decreased cell viability. fluorescence-activated cell sorter analysis showed that it induced g1 cell cycle arrest without increasing the ... | 2017 | 28385009 |
| a novel system for predicting liver histopathology in patients with chronic hepatitis b. | there is currently a lack of reliable, reproducible, and easily applied methods for assessing changes in liver histology in patients in the gray zone phase of chronic hepatitis b (chb). therefore, we aimed to develop a novel predictive scoring system to detect significant liver histological changes in these patients.a total of 388 patients in the gray zone phase of chb who underwent liver biopsy were divided into a training group and a validation group, and their clinical and routinely available ... | 2017 | 28383410 |
| a consensus for occupational health management of healthcare workers infected with human immunodeficiency virus, hepatitis b virus, and/or hepatitis c virus. | occupational health management plays an important role in the prevention of provider-to-patient transmission in healthcare workers infected with human immunodeficiency virus (hiv), hepatitis b virus (hbv), and/or hepatitis c virus (hcv). therefore, the japan society for occupational health's scientific committee of occupational health for health care workers has proposed a consensus for the management of healthcare workers infected with hiv, hbv, and/or hcv based on recent evidence for each conc ... | 2017 | 28381816 |
| occult hepatitis b virus infection in hyperlipidemia patients. | chronic hepatitis b virus (hbv) infection is associated with lower prevalence of hyperlipidemia (hlp). however, occult hbv infection (obi) in hlp patients has not yet been explored. obi is defined as the presence of detectable hbv dna in serum or liver tissue but undetectable hbv surface antigen in serum. in this study, 1,036 hlp patients and 1,134 replacement blood donor controls were recruited. among them, 252 hlp patients and 255 blood donors with antibody to hbv core positive were selected a ... | 2017 | 28381700 |
| the impact of hepatitis b virus infection and vaccination on the development of non-hodgkin lymphoma. | hepatitis b virus (hbv) infection has been documented as a risk factor for non-hodgkin lymphoma (nhl). however, there are few large cohort studies, and there is no report about the impact of hbv vaccination. we conducted this study to evaluate these issues. | 2017 | 28375587 |
| higher disappearance rate of anti-hbs in taiwanese freshers neonatally vaccinated with recombinant yeast hepatitis b vaccine. | to compare the long term efficacy of infant recombinant yeast hepatitis b vaccine (recombinant group) and infant plasma-derived one (plasma group) in taiwanese freshers. | 2017 | 28374906 |
| elevated expression of chemokine cxcl13 in chronic hepatitis b patients links to immune control during antiviral therapy. | c-x-c-chemokine ligand 13 (cxcl13), the ligand for c-x-c chemokine receptor type 5 (cxcr5), is a major regulator of b-cell trafficking and plays an integral role in age-dependent clearance of hepatitis b virus (hbv) in the mouse model. however, the expression and function of cxcl13 in patients with chronic hepatitis b (chb) remain unknown. by use of liver cell subpopulations isolated from chb patients, we found that cxcl13 mrna was abundantly expressed in kupffer cells (kcs), but not in primary ... | 2017 | 28386259 |
| improvement of liver fibrosis after long-term antiviral therapy assessed by fibroscan in chronic hepatitis b patients with advanced fibrosis. | performing repeated liver biopsies to assess the improvement of liver fibrosis is impractical. the purpose of this prospective cohort study was to assess the improvement of liver fibrosis during antiviral treatment by serial liver stiffness (ls) measurement using fibroscan in chronic hepatitis b (chb) patients with advanced fibrosis. | 2017 | 28374814 |
| evolution of full-length genomes of hbv quasispecies in sera of patients with a coexistence of hbsag and anti-hbs antibodies. | although the evolutionary changes of viral quasispecies are correlated to the pathological status of a disease, little is known in the coexistence of hepatitis b surface antigen (hbsag) and antibodies to these antigens (anti-hbs). to examine evolutionary changes in hepatitis b virus (hbv) and their relationship to the coexistence of hbsag and anti-hbs antibodies, hbv genomes in patients with a coexistence of hbsag and anti-hbs antibodies (experimental group) and hbsag positive without anti-hbs ( ... | 2017 | 28386078 |
| transbody against virus core protein potently inhibits hepadnavirus replication in vivo: evidence from a duck model of hepatitis b virus. | 2017 | 28383135 | |
| human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis b virus infection. | in order to understand the life cycle of hepatitis b virus (hbv) and to develop efficient anti-hbv drugs, a useful in vitro cell culture system which allows hbv infection and recapitulates virus-host interactions is essential; however, pre-existing in vitro hbv infection models are often problematic. here, we examined the potential of human induced-pluripotent stem (ips) cell-derived hepatocyte-like cells (ips-hlcs) as an in vitro hbv infection model. expression levels of several genes involved ... | 2017 | 28374759 |
| increased erp57 expression in hbv-related hepatocellular carcinoma: possible correlation and prognosis. | aim. erp57 is involved in virus induced endoplasmic reticulum stress (ers) and plays an important role in tumorigenesis. this study aimed to find whether hbv infection altered erp57 expression and whether erp57 regulation was involved in hepatitis b virus-related hepatocellular carcinoma (hbv-hcc) genesis. materials and methods. hbv-hcc tissues, chronic hepatitis b (chb) liver tissues, and normal liver tissues were acquired. erp57 expressions in these tissues were detected through immunohistoche ... | 2017 | 28373975 |
| the clinical efficacy and adverse effects of interferon combined with matrine in chronic hepatitis b: a systematic review and meta-analysis. | currently, many studies have demonstrated certain beneficial effects of interferon (ifn) combined with matrine (mat) for chronic hepatitis b (chb) in china. however, the evidence from these randomized control trials is still controversial. therefore, the aim of this meta-analysis was to explore the efficacy and safety of mat combined with ifn for chb. we performed a systematic search of seven databases to identify all randomized controlled trials that treated chb with ifn or ifn plus mat from th ... | 2017 | 28382770 |
| prevalence and influencing factors of hepatitis b among a rural residential population in zhejiang province, china: a cross-sectional study. | to reveal the prevalence and associated influencing factors of hepatitis b among a rural residential population in zhejiang, china, in order to help develop specific control strategies. | 2017 | 28373257 |
| allogeneic bone marrow-derived mesenchymal stromal cells for hbv-related acute-on-chronic liver failure: a randomized controlled trial. | mortality from hepatitis b virus (hbv)-related acute-on-chronic liver failure (aclf) is high due to limited treatment options. preclinical and clinical investigations have proved that treatment with mesenchymal stromal cells (mscs) is beneficial for recovery from liver injury. we hypothesized that the outcome of hbv-related aclf would be improved by msc treatment. from 2010 to 2013, 110 patients with hbv-related aclf were enrolled in this open label non-blinded randomized controlled study. the c ... | 2017 | 28370357 |
| development of a novel site-specific pegylated interferon beta for antiviral therapy for chronic hepatitis b. | although nucleot(s)ide analogues and pegylated-interferon-α2a (peg-ifnα2a) can suppress hepatitis b virus (hbv) replication, it is difficult to achieve complete hbv elimination from hepatocytes. a novel site-specific pegylated recombinant human ifnβ (trk-560) was recently developed. in the present study, we evaluated the antiviral effects of trk-560 on hbv replication in vitro and in vivoin vitro and in vivo hbv replication models were treated with antivirals including trk-560, and changes in hb ... | 2017 | 28373196 |
| sequence analysis and functional characterization of full-length hepatitis b virus genomes from korean cirrhotic patients with or without liver cancer. | this study aimed to identify and characterize mutations in the hepatitis b virus (hbv) genome associated with advanced liver diseases. the 3.2-kb hbv genome of the c2 subgenotype was amplified from sera of 18 cirrhotic korean patients with (10) or without (8) hepatocellular carcinoma (hcc), and two clones per patient were characterized by transient transfection experiments in human hepatoma cells. while a1762t/g1764a core promoter mutations were highly prevalent in both groups, the g1896a precor ... | 2017 | 28373061 |
| clinical and pathological significance of myeloid differentiation factor 88 expression in human hepatocellular carcinoma tissues. | the innate immune system, which includes toll-like receptor (tlr) signaling, plays an important role in inflammation and oncogenesis. although tlr common adaptor myeloid differentiation factor 88 (myd88) is known to have multiple effects on carcinogenesis, the role of myd88 in hepatocarcinogenesis remains unknown. in this study, myd88 expression was examined in 105 samples of human hepatocellular carcinoma (hcc) tissue by immunohistochemistry, western blot, and quantitative reverse-transcriptase ... | 2017 | 28370778 |
| pregnancy and maternal chronic hepatitis b infection-evidence of reproductive advantage? | as multiparas have high prevalence of chronic hepatitis b virus (hbv) infection, we examined here the relationship between the number of pregnancies with hbv infection. | 2017 | 28370686 |
| past, current, and future developments of therapeutic agents for treatment of chronic hepatitis b virus infection. | for decades, treatment of hepatitis b virus (hbv) infection has been relying on interferon (ifn)-based therapies and nucleoside/nucleotide analogs (nas) that selectively target the viral polymerase reverse transcriptase (rt) domain and thereby disrupt hbv viral dna synthesis. we have summarized here the key steps in the hbv viral life cycle, which could potentially be targeted by novel anti-hbv therapeutics. a wide range of next generation direct antiviral agents (daas) with distinct mechanisms ... | 2017 | 28383274 |
| monotherapy with tenofovir disoproxil fumarate for multiple drug-resistant chronic hepatitis b: 3-year trial. | combination therapy has been recommended for the treatment of patients harboring multiple drug-resistant hepatitis b virus (hbv). however, we recently demonstrated that monotherapy with tenofovir disoproxil fumarate (tdf) for 48 weeks displayed non-inferior efficacy to tdf plus entecavir (etv) combination therapy in patients with hbv resistant to multiple drugs, including etv and adefovir, respectively. nonetheless, whether prolonged tdf monotherapy would be safe and increase the virologic respon ... | 2017 | 28370419 |
| removal of integrated hepatitis b virus dna using crispr-cas9. | the presence of hepatitis b virus (hbv) covalently closed circular dna (cccdna) and the permanent integration of hbv dna into the host genome confers the risk of viral reactivation and hepatocellular carcinoma. nucleoside/nucleotide analogs alone have little or no capacity to eliminate replicative hbv templates consisting of cccdna or integrated hbv dna. recently, crispr/cas9 technology has been widely applied as a promising genome-editing tool, and hbv-specific crispr-cas9 systems were shown to ... | 2017 | 28382278 |
| topic: "the level of nurses' knowledge on occupational post exposure to hepatitis b infection in the tamale metropolis, ghana". | health care workers especially nurses in developing countries are at serious risk for infection from blood-borne pathogens particularly hepatitis b virus (hbv) - because of the high prevalence of such pathogens in many poorer regions of the world. employers are required to establish exposure-control plans that include post exposure follow-up for their employees and to comply with incident reporting requirements. this study assessed the level of knowledge and awareness of nurses in the tamale met ... | 2017 | 28381257 |
| a single center analysis of the positivity of hepatitis b antibody after neonatal vaccination program in korea. | the antibody to hepatitis b surface antigen (anti-hbs) seropositivity rate after 3 doses of hepatitis b virus (hbv) vaccination during infancy period is known to be higher than 90%. however, a considerable number of vaccines do not form protective anti-hbs or chronologic decrease of anti-hbs. we retrospectively collected data of hbv serologic test results in 20,738 individuals from 2000 to 2015. after exclusion criteria were applied, 19,072 individuals were included. we analyzed the anti-hbs ser ... | 2017 | 28378555 |
| acute infectious hepatitis in hospitalised children: a british paediatric surveillance unit study. | hepatitis remains a key public health priority globally. most childhood cases are caused by viruses, especially hepatitis a virus (hav) and hepatitis b virus (hbv). this study aimed to estimate the burden of acute infectious hepatitis in hospitalised children and to describe their clinical characteristics and outcomes. | 2017 | 28377449 |
| antiviral efficacy of entecavir for hepatitis b virus rta181v/t mutants. | the amino acid substitution at position 181 of the hepatitis b virus (hbv) polymerase is a multi-drug resistance affecting both the l-nucleoside and acyclic phosphonate nucleotide groups. data is limited on the efficacy of entecavir (etv) rescuing chronic hepatitis b (chb) patients with rta181t/v mutation. | 2017 | 28376852 |
| incidence and clinical characteristics of hepatitis b virus reactivation in hbsag-negative/hbcab-positive patients receiving rituximab for rheumatoid arthritis. | to analyse the incidence, clinical characteristics, and prognosis of patients with rheumatoid arthritis (ra) and hepatitis b virus (hbv) surface antigen negative/core antibody positive serostatus (hbsag-/hbcab+), who underwent rituximab therapy and developed hbv reactivation. | 2017 | 28375829 |
| gene expression profile after knockdown of usp18 in hepg2.2.15 cells. | in our previous work, we found that the expression of ubiquitin-specific protease 18 (usp18), also known as ubp43, is associated with the efficiency of interferon alpha (ifn-α) treatment in patients with chronic hepatitis b (chb). to elucidate the influence of usp18 on hepatitis b virus (hbv) replication and the mechanism of this activity, we silenced usp18 by introducing short hairpin rna (shrna) into hepg2.2.15 cells. to identify the changed genes and pathways in hepg2.2.15-shrna-usp18 cells, ... | 2017 | 28369997 |
| chronic hepatitis b: immunological profile and current therapeutic vaccines in clinical trials. | more than 250million people worldwide are chronically infected with hepatitis b virus (chb), and over half a million die each year due to chb-associated liver complications such as cirrhosis and hepatocellular carcinoma. the translation of immunological knowledge about chb into therapeutic strategies aiming to a sustainable hepatitis b virus (hbv) clearance has been challenging. in recent years, however, the understanding on the immune effectors required to overcome chronicity has notably increa ... | 2017 | 28351734 |
| on-treatment hbv dna dynamics predict virological breakthrough in entecavir-treated hbeag-positive chronic hepatitis b. | virological breakthrough (vbt) could be a manifestation of chronic hepatitis b (chb) in patients treated with long-term nucleot(s)ide analogues. we aimed to determine the association of on-treatment serum hepatitis b virus (hbv) dna with vbt in hbeag-positive chb patients receiving entecavir (etv) treatment. | 2017 | 28350873 |
| role of p63 and p73 isoforms on the cell death in patients with hepatocellular carcinoma submitted to orthotopic liver transplantation. | patients with hepatocellular carcinoma (hcc) submitted to orthotopic liver transplantation (olt) have a variable 5-year survival rate limited mostly by tumor recurrence. the etiology, age, sex, alcohol, child-pugh, and the immunesuppressor have been associated with tumour recurrence. the expression of δnp73 is related to the reduced survival of patients with hcc. the study evaluated the expression of p63 and p73 isoforms and cell death receptors, and their relation to tumour recurrence and survi ... | 2017 | 28350813 |
| prevalence of hepatitis b and c and factors for infection and nonimmune in inflammatory bowel disease patients in china. | the aims of this study were to investigate the prevalence of hepatitis b virus (hbv) and hepatitis c virus (hcv) infection in inflammatory bowel disease (ibd) patients and the risk factors related to the infection and nonimmune status. | 2017 | 28350740 |
| mortality associated with hepatitis c and hepatitis b virus infection: a nationwide study on multiple causes of death data. | to analyze mortality associated with hepatitis c virus (hcv) and hepatitis b virus (hbv) infection in italy. | 2017 | 28348493 |
| integrated analysis of microrna and mrna expression profiles in hbx-expressing hepatic cells. | to identify the mirna-mrna regulatory network in hepatitis b virus x (hbx)-expressing hepatic cells. | 2017 | 28348484 |
| hepatitis b virus infection is associated with younger median age at diagnosis and death in cancers. | several non-hepatocellular cancers were linked with hepatitis b virus (hbv) infection. this study was aimed to quantify the potential associations between hbv infection and multiple non-hepatocellular cancers. continuous cases, including 5,715 non-cancer and 40,963 cancer cases diagnosed from 2008 to 2014 in sun yat-sen university cancer center were analyzed. hbv dna and hepatitis b core antigen (hbcag) were examed in gastric cancer tissues by polymerase chain reaction and immunohistochemical st ... | 2017 | 28369849 |
| role of quantitative hepatitis b surface antigen in predicting inactive carriers and hbsag seroclearance in hbeag-negative chronic hepatitis b patients. | to evaluate quantitative hepatitis b surface antigen (qhbsag) as a diagnostic marker for inactive carriers (ics) and hepatitis b surface antigen (hbsag) seroclearance in hepatitis b e antigen (hbeag)-negative chronic hepatitis b (chb) patients. we retrospectively studied 300 hbeag-negative chb patients with initial serum hepatitis b virus (hbv) deoxyribonucleic acid (dna) levels <2000 iu/ml. serum hbv dna and alanine aminotransferase (alt) levels were monitored every 6 months for 24 months. ics ... | 2017 | 28353619 |
| using health-system-wide data to understand hepatitis b virus prophylaxis and reactivation outcomes in patients receiving rituximab. | hepatitis b virus (hbv) reactivation in the setting of rituximab use is a potentially fatal but preventable safety event. the rate of hbv screening and proportion of patients at risk who receive antiviral prophylaxis in patients initiating rituximab is unknown.we analyzed electronic health record (ehr) data from 2 health systems, a university center and a safety net health system, including diagnosis grouper codes, problem lists, medications, laboratory results, procedures codes, clinical encoun ... | 2017 | 28353614 |
| breastfeeding from mothers carrying hbv would not increase the risk of hbv infection in infants after proper immunoprophylaxis. | previously meta-analysis had different conclusions about the role of breastfeeding in mother-to-child transmission (mtct) of hepatitis b virus (hbv). we aimed to carry out an updated meta-analysis based on current published evidence to explore whether breastfeeding increase the risk of hbv infection from mothers carrying hbv after proper immunoprophylaxis in the infants or not. | 2017 | 28353321 |
| a novel phenotypic assay of hepatitis b virus polymerase with extensive site-specific mutagenesis. | 2017 | 28353186 | |
| deep sequencing analysis of quasispecies in the hbv pre-s region and its association with hepatocellular carcinoma. | the association between the evolution of hepatitis b virus (hbv) quasispecies and the development of hepatocellular carcinoma (hcc) is unknown. | 2017 | 28353014 |
| plasma microrna levels are associated with hbeag status and treatment response in chronic hepatitis b patients. | hepatitis b virus (hbv) modulates mirna expression to support viral replication. the aim of this study was to identify mirnas associated with hbeag-status and response to antiviral therapy in chronic hepatitis b (chb) patients, and to assess if these mirnas are secreted by hepatoma cells. | 2017 | 28368488 |
| identifying and characterizing interplay between hepatitis b virus x protein and smc5/6. | hepatitis b x protein (hbx) plays an essential role in the hepatitis b virus (hbv) replication cycle, but the function of hbx has been elusive until recently. it was recently shown that transcription from the hbv genome (covalently-closed circular dna, cccdna) is inhibited by the structural maintenance of chromosome 5/6 complex (smc5/6), and that a key function of hbx is to redirect the dna-damage binding protein 1 (ddb1) e3 ubiquitin ligase to target this complex for degradation. by doing so, h ... | 2017 | 28368357 |
| circulating levels of collagen iii and mmp-1 in patients with chronic hepatitis c co-infected with hepatitis b virus. | there is controversial data in the literature about the characteristics and features of dual hepatitis b and hepatitis c infection. this work is concerned with estimating the extent to which hbv could influence circulating levels of hepatitis c viral nonstructural-4 (hcv-ns4) in addition to some direct fibrosis markers in chronic hepatitis c. | 2017 | 28367737 |
| secreted interferon-inducible factors restrict hepatitis b and c virus entry in vitro. | interferon-α (ifn-α) has been used for more than 20 years as the first-line therapy for hepatitis b virus (hbv) and hepatitis c virus (hcv) infection, because it has a number of antiviral effects. in this study, we describe a novel mode of its antiviral action. we demonstrate that the supernatant from ifn-α-treated cultured cells restricted hbv and hcv infection by inhibiting viral entry into hepatoma cells. the factors contained in the supernatant competed with the virus for binding to heparan ... | 2017 | 28367455 |
| comparison of knowledge and attitudes regarding hepatitis b among healthcare professionals in pakistan. | hepatitis b virus (hbv) is a blood-borne infectious disease. it is one of the most common causes of end-stage liver disease, including cirrhosis and hepatocellular carcinoma. healthcare professionals, including medical and dental students, are at a high risk of acquiring this infection. the aim of this study was to compare and contrast the knowledge and attitudes toward hbv infection amongst doctors, dentists, nurses, and undergraduate final year medical and dental students. | 2017 | 28367387 |
| assessment of immunization to hepatitis b vaccine among children under five years in rural areas of taiz, yemen. | background. hepatitis b virus (hbv) infection poses a major health problem worldwide. approximately 1 million deaths annually due to cirrhosis and hepatocellular carcinoma. objectives. this study was conducted to determine the coverage rate of hbv vaccine and assess the vaccine protective response among children under five years old in rural areas of yemen. methods. a cross-sectional study was conducted from january to december 2015 in four districts of countryside yemen. the target population w ... | 2017 | 28367327 |
| the 50 most-cited articles in gastroenterology and hepatology from mainland china. | to identify and analyze the 50 most-cited gastroenterology and hepatology articles originating from mainland china. | 2017 | 28367203 |
| hepatitis b virus induced cytoplasmic antineutrophil cytoplasmic antibody-mediated vasculitis causing subarachnoid hemorrhage, acute transverse myelitis, and nephropathy: a case report. | transverse myelitis, subarachnoid hemorrhage, and nephropathy are established but rare complications of hepatitis b virus infection that can potentially be triggered by an antibody-mediated vasculitis as a result of a viral infection. the following is a case report detailing a patient presenting with all three of the above presentations who is cytoplasmic antineutrophil cytoplasmic antibody-positive and a chronic carrier of hepatitis b. | 2017 | 28366165 |
| a circulating microrna signature capable of assessing the risk of hepatocellular carcinoma in cirrhotic patients. | with the availability of potent antiviral therapies, complete suppression of hepatitis b virus (hbv) replication and total eradication of hepatitis c virus (hcv) can now be achieved. despite these advances, hepatocellular carcinoma (hcc) still develops in a substantial proportion of cirrhotic patients, suggesting that host factors remain critical. dysregulation of mirnas is noted in many cancers, and circulating mirnas can be readily assayed. in this study, we aimed to develop a circulating mirn ... | 2017 | 28364124 |
| plasma apolipoprotein a-v predicts long-term survival in chronic hepatitis b patients with acute-on-chronic liver failure. | hepatitis b virus-related acute-on-chronic liver failure (hbv-aclf) is a life-threatening condition, and the lipid metabolism disorder is common in the development of this disease. this prospective observational study aimed to define the characteristics of plasma apolipoprotein a-v (apoa-v) in long-term outcome prediction of hbv-aclf, and a total of 330 hbv-aclf patients were included and followed for more than 12 months. in this cohort, the 4-week, 12-week, 24-week and 48-week cumulative mortal ... | 2017 | 28358016 |
| association of p53 codon 72 polymorphism with susceptibility to hepatocellular carcinoma in a chinese population from northeast sichuan. | the p53 tumor suppressor gene is key in tumor development and progression, and the single nucleotide polymorphism (snp) of the p53 gene codon 72 (p53arg/pro) changes the structure of the protein. in addition, it affects its activity, which may affect cancer risk. the aim of the present study was to investigate the association between p53 codon 72 polymorphism and susceptibility to hepatocellular carcinoma (hcc) in a chinese population from northeast sichuan. a total of 342 hcc patients and 347 n ... | 2017 | 28357076 |
| factors associated with long-term survival after liver transplantation: a retrospective cohort study. | to identify predictive factors associated with long-term patient and graft survival (> 15 years) in liver transplant recipients. | 2017 | 28357030 |
| [effect of lamivudine and silymarin on liver fibrosis-relevant factors in hbv transgenic mice with alcohol drinking]. | to observe the role of lamividine and silymarin preventing and curing liver fibrosis-relevant factors induced by alcohol drinking in hepatitis b virus (hbv) transgenic mice (tg mice). methods: forty hbv-tg balb/c mice with 1.3 copy were randomly divided into 4 groups: a control group, a model group, a lamivudine group and a silymarin group. tg mice in control group were treated with normal saline via intragastric administration; tg-mice in the model group were treated with 50% alcohol (5 ml/kg) ... | 2017 | 28364097 |
| interferon induces interleukin 8 and bone marrow stromal cell antigen 2 expression, inhibiting the production of hepatitis b virus surface antigen from human hepatocytes. | hepatitis b virus (hbv) surface antigen (hbsag) loss is one of the treatment goals of chronic hbv infection. bone marrow stromal cell antigen 2 (bst2) is one of the interferon (ifn)-stimulated genes (isgs) and inhibits the release of various enveloped viruses. here we examined the effects of antiviral treatment on hbsag levels and its intracellular mechanism in hbsag-producing hepatocytes. in plc/prf/5 and huh1, ifnα-2a treatment decreased hbsag levels in their conditioned media. upregulation of ... | 2017 | 28363866 |
| the social stigma experience in patients with hepatitis b infection: a qualitative study. | the social stigma in patients with hepatitis b virus infection has caused several complications for both the patients and the associated medical system. this study aimed at demonstrating the social stigma experienced by these patients in iran. this is a qualitative study using a content analysis approach with references to primary and secondary sources. the data were collected through 15 unstructured and in-depth interviews conducted in 2014. by analyzing the data, two main themes were noted: ex ... | 2017 | 28362662 |
| liver fibrosis regression and progression during controlled hepatitis b virus infection among hiv-hbv patients treated with tenofovir disoproxil fumarate in france: a prospective cohort study. | long-term tenofovir disoproxil fumarate (tdf) use has been associated with significant regression of liver fibrosis during hepatitis b virus (hbv) mono-infection, yet little is known during hiv-hbv coinfection. the aim of this study was to evaluate the evolution of liver fibrosis and its determinants in tdf-treated coinfected patients. | 2017 | 28362068 |
| alcohol use, viral hepatitis and liver fibrosis among hiv-positive persons in west africa: a cross-sectional study. | liver fibrosis is often the first stage of liver disease in people living with hiv (plwhiv) in industrialized countries. however, little is known about liver fibrosis and its correlates among plwhiv in sub-saharan africa. | 2017 | 28362065 |
| identification of novel a2/c2 inter-genotype recombinants of hepatitis b virus from a korean chronic patient co-infected with both genotype a2 and c2. | nearly all cases of hepatitis b virus (hbv) infections in south korea have the c2 genotype. here, we have identified a chronically infected patient who was co-infected with hbv of both the a2 and c2 genotypes by screening 135 korean chronically infected patients using direct sequencing protocols targeting the 1032-bp polymerase reverse transcriptase (rt) region. further polymerase chain reaction (pcr)-cloning analysis (22 clones) of the rt showed that this patient had genotype c2 (12 clones), ge ... | 2017 | 28358313 |
| liver function tests abnormalities and hepatitis b virus & hepatitis c virus co-infection in human immunodeficiency virus (hiv)-infected patients in india. | while highly active anti-retroviral therapy (haart) has improved survival of hiv-infected patients, there is increasing liver disease and progressive hepatitis b virus (hbv) and hepatitis c virus (hcv) related liver disease. | 2017 | 28348464 |
| high expression of g-protein signaling modulator 2 in hepatocellular carcinoma facilitates tumor growth and metastasis by activating the pi3k/akt signaling pathway. | the aim of this study was to investigate the role of g-protein signaling modulator 2 in the carcinogenesis and progression of hepatocellular carcinoma. we previously showed that g-protein signaling modulator 2 was upregulated in hepatitis b virus-related hepatocellular carcinoma tissues through a hierarchical clustering analysis. with this study, we first assessed the expression pattern of g-protein signaling modulator 2 in hepatocellular carcinoma specimens and adjacent noncancerous tissues; cl ... | 2017 | 28347229 |
| natural killer cell activation contributes to hepatitis b viral control in a mouse model. | the roles of cd4 + t cells and cd8 + t cells in hepatitis b virus (hbv) infection have been well documented. however, the role of innate immunity in hbv infection remains obscure. here we examined the effect of activation of innate immunity by polyinosinic: polycytidylic acid (polyi:c) on hbv infection. a chronic hbv replication mouse model was established by hydrodynamical injection of paav/hbv1.2 plasmid into c57bl/6 mice. we found that hbv did not seem to induce an active nk-cell response in ... | 2017 | 28331190 |
| off-treatment hepatitis b virus (hbv) dna levels and the prediction of relapse after discontinuation of nucleos(t)ide analogue therapy in patients with chronic hepatitis b: a prospective stop study. | the optimal management remains unknown after nucleos(t)ide analogue (na) discontinuation in patients with chronic hepatitis b (chb). this prospective study investigated the role of off-treatment viral kinetics in predicting relapse after discontinuation of na therapy. | 2017 | 28329347 |
| association of mutations in tlr2 signaling genes with fulminant form of hepatitis b related acute liver failure. | fulminant form of hepatitis b related acute liver failure (fhb-alf) is a rare but highly fatal outcome of acute hepatitis b virus (hbv) infection. its related host factors have not been studied. | 2017 | 28329297 |
| pegylated interferon alfa-2b add-on treatment in hepatitis b virus envelope antigen-positive chronic hepatitis b patients treated with nucleos(t)ide analogue: a randomized, controlled trial (pegon). | we studied whether 48 weeks of pegylated interferon alfa-2b (peginterferon) add-on therapy increases serological response in hepatitis b virus (hbv) envelope antigen (hbeag)-positive patients receiving nucleos(t)ide analogue (na) therapy, compared with continued na monotherapy. | 2017 | 28329061 |
| frequency and role of nkp46 and nkg2a in hepatitis b virus infection. | natural killer (nk) cells are involved in the control of viral infection. however, the role of nk cells in chronic hepatitis b (chb) remains unclear. this study investigated the frequencies and roles of nk cells in chb, with a focus on activating receptor nkp46 and inhibitory receptor nkg2a. | 2017 | 28328926 |
| dynamic and specific immune responses against multiple tumor antigens were elicited in patients with hepatocellular carcinoma after cell-based immunotherapy. | hepatocellular carcinoma (hcc) is one of the most common cancers in china and frequently occurs with chronic hepatitis b virus infection. to investigate whether cell-based cancer immunotherapy induces tumor specific immune responses in patients with hcc and provides clinical benefits, as well as to elucidate the most immunogenic tumor associated antigens (taas), multiple antigen stimulating cellular therapy (masct) was applied in addition to standard of care. | 2017 | 28330473 |
| hepatitis b and c virus infections among human immunodeficiency virus-infected people who inject drugs in lahore, pakistan. | hepatitis b virus (hbv) and hepatitis c virus (hcv) are the major cause of the global burden of hepatitis. one of the main routes of transmission for both viruses is through exposure to infected blood, which includes sharing blood-contaminated syringes and needles. human immunodeficiency virus (hiv) attacks the immune system and results in acquired immune deficiency syndrome and opportunistic infections. the objective of this study was to assess the epidemiology of hbv and hcv infections among h ... | 2017 | 28346804 |
| hepatitis b virus prevalence in rural areas in south-west chad. | in chad, hepatitis b virus (hbv) is thought to have a high prevalence and is consequently responsible for numerous acute and long-term complications. it is often detected during screening in potential blood donors. however, no general population-based study on the prevalence of hepatitis b has been performed. the aim of this study was to gain an impression of the hbv prevalence in rural areas in south-west chad. a total of 1309 individuals (745 boys/men, 564 girls/women) with a median age of 15 ... | 2017 | 28345397 |
| linc00152 promotes cancer progression in hepatitis b virus-associated hepatocellular carcinoma. | the x protein (hbx) plays as a key role in hepatocarcinogenesis associated with hepatitis b virus (hbv) infections. the study aimed to figure out the role of linc00152 in hepatocellular carcinoma (hcc) and the association between the expression levels of linc00152 and hbx. | 2017 | 28343069 |
| f221y mutation in hepatitis b virus reverse transcriptase is associated with hepatocellular carcinoma prognosis following liver resection. | hepatitis b virus (hbv) reverse transcriptase (rt) is encoded by the polymerase gene in the reverse transcriptase region, which overlaps with the s gene. the association between mutations of hbv rt and the pathobiological features of hepatocellular carcinoma (hcc) remain to be elucidated. the present study aimed to examine mutations in this region of the hbv genome and its clinical significance. briefly, hbv total dna was extracted from 84 pairs of hcc tumor tissue and corresponding adjacent non ... | 2017 | 28339094 |
| hbx represses riz1 expression by dna methyltransferase 1 involvement in decreased mir-152 in hepatocellular carcinoma. | hepatitis b virus (hbv) is mainly suspected to promote hepatocellular carcinoma (hcc) development by epigenetic alteration. the hbv x protein (hbx) plays a key role in the molecular pathogenesis of hbv-related hcc. however, the mechanism of hbx-mediated hepatocarcinogenesis remains to be elucidated. riz1 gene, a candidate hcc suppressor gene, is frequently found to be hypermethylated and downregulated in hcc. in the present study, we show that the expression of riz1 was downregulated in 65% hcc ... | 2017 | 28339081 |
| hepatitis b virus x protein increases microrna‑21 expression and accelerates the development of hepatoma via the phosphatase and tensin homolog/phosphoinositide 3‑kinase/protein kinase b signaling pathway. | hepatitis b virus (hbv) x protein (hbx) is a key regulatory protein that is involved in hbv infection, replication and carcinogenesis of hepatocellular carcinoma (hcc). the aim of the present study was to investigate the role of hbx in the progression and metastasis of liver cancer cells and to determine the underlying molecular mechanism of hbx in metastatic liver cancer cells. hbx protein expression was detected by western blot analysis, and microrna (mir)‑21 levels were determined by reverse ... | 2017 | 28339072 |
| establishment of a human hepatocellular cell line capable of maintaining long-term replication of hepatitis b virus. | hepatitis b virus is a virus whose replication cycle cannot be completely reproduced using cultured cell lines. here, we report an engineered cell line capable of supporting the complete hbv life cycle. we generated hepg2 cells overexpressing hbv entry receptor human ntcp, and defective in rig-i-like receptor signaling, by knocking down the ips-1 adaptor molecule. the resultant ntg20.i7 cells were susceptible to hbv, and its replication was detectable at 14 days post-infection and persisted for ... | 2017 | 28338936 |
| hepatitis b in solid-organ transplant procedures other than liver. | transplant is often the best treatment available for patients with end-stage organ failure. hepatitis b virus infection in transplant procedures other than liver is a major concern because it can be a significant cause of morbidity and mortality after transplant. due to the increased risk of hepatic complications, such as fibrosing cholestatic hepatitis or histologic deterioration after transplant, systematic use of nucleoside or nucleotide analogues shortly before or at the time of transplant i ... | 2017 | 28338458 |
| association between hepatitis b and hearing status. | this study was performed to investigate the correlation between the chronic hepatitis b virus infection and hearing status. this study was performed to investigate the correlation between the chronic hepatitis b virus infection and hearing status. | 2017 | 28338205 |
| evaluating histologic differentiation of hepatitis b virus-related hepatocellular carcinoma using intravoxel incoherent motion and afp levels alone and in combination. | to evaluate histologic differentiation of hepatitis b virus (hbv)-related hepatocellular carcinomas (hccs) using apparent diffusion coefficient (adc) and intravoxel incoherent motion (ivim)-derived metrics and to compare findings with alpha-fetoprotein (afp) levels alone and in combination. | 2017 | 28337521 |
| erbb4 acts as a suppressor in the development of hepatocellular carcinoma. | erbb4, one member of the epidermal growth factor receptor (egfr) family, plays a key role in physiological and pathological processes. recently, we identified that erbb4 played a protective role from chronic hepatitis b virus infection. however, the role of erbb4 in hepatocellular carcinoma (hcc) is still unclear. here, we explore the role of erbb4 in the development of hcc using in vitro models, in vivo animal models and clinical samples of hcc. liver-specific erbb4 knockout alleles and full er ... | 2017 | 28334319 |