Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| human stem cell-derived hepatocytes as a model for hepatitis b virus infection, spreading and virus-host interactions. | one major obstacle of hepatitis b virus (hbv) research is the lack of efficient cell culture system permissive for viral infection and replication. the aim of our study was to establish a robust hbv infection model by using hepatocyte-like cells (hlcs) derived from human pluripotent stem cells. | 2017 | 27746336 |
| gene editing: a new tool for viral disease. | the emergence of the crispr/cas system of antiviral adaptive immunity in bacteria as a facile system for gene editing in mammalian cells may well lead to gene editing becoming a novel treatment for a range of human diseases, especially those caused by deleterious germline mutations. another potential target for gene editing are dna viruses that cause chronic pathogenic diseases that cannot be cured by using currently available drugs. we review the current state of this field and discuss the pote ... | 2017 | 27576009 |
| time trends of chronic hbv infection over prior decades - a global analysis. | information on trends in chronic hepatitis b virus (hbv) prevalence across countries is lacking. we studied changes in chronic hbv infection over previous decades by country, and assessed patterns of change between and within who-defined regions. | 2017 | 27592304 |
| splenic diffuse red-pulp small b-cell lymphoma associated with hepatitis b virus: a report of two cases. | splenic diffuse red-pulp small b-cell lymphoma is a rare disease, representing less than 1% of all non-hodgkin lymphomas (nhl). this entity is characterized by involvement of bone marrow sinusoids and peripheral blood. the majority of cases are at an advanced stage when diagnosed. its pathogenesis is still poorly understood. | 2017 | 27581334 |
| optimizing outcomes in pediatric renal transplantation through the australian paired kidney exchange program. | kidney paired donation (kpd) programs offer the opportunity to enable living kidney donation when immunological and other barriers prevent safe directed donation. children are likely to require multiple transplants during their lifetime; therefore, high-level histocompatibility and organ quality matching are key priorities. details are given for a cohort of seven pediatric renal transplantations performed through the australian kidney exchange (akx), including barriers to alternative transplanta ... | 2017 | 27597398 |
| a study on confidential unit exclusion at shiraz blood transfusion center, iran. | confidential unit exclusion (cue) system has been designed to enhance transfusion safety as an extra additive approach. | 2017 | 27605850 |
| complement 5a is an indicator of significant fibrosis and earlier cirrhosis in patients chronically infected with hepatitis b virus. | to investigate the association between serum complement 5a (c5a) concentration and liver fibrosis and cirrhosis in a large cohort of patients chronically infected with hepatitis b virus (hbv). | 2017 | 27605044 |
| hepatitis b virus infection in children of hbv-related chronic liver disease patients: a study of intra-familial hbv transmission. | hbv-infected patients are potential sources of intra-familial transmission. we studied hbv transmission and molecular characteristics within families of hbv-related chronic liver disease (cld) patients. | 2017 | 27624502 |
| a combination of different diagnostic tools allows identification of inactive hepatitis b virus carriers at a single time point evaluation. | serial evaluation of hepatitis b virus (hbv) dna and aminotransferase values is required for identification of inactive hbv carriers (ics). recently, hbv surface antigen quantification (qhbsag) and liver stiffness measurement (lsm) have been proposed as diagnostic tools in chronic hbv infection. the aim of this study was to evaluate the efficacy of hbv dna quantification, qhbsag and lsm in diagnosing ics at a single time point. | 2017 | 27606573 |
| predictors of liver disease severity in children with chronic hepatitis b. | evaluation of the liver histology is essential for the management of chronic hepatitis b (chb) in children. | 2017 | 27629842 |
| simplification to dual therapy (atazanavir/ritonavir + lamivudine) versus standard triple therapy [atazanavir/ritonavir + two nucleos(t)ides] in virologically stable patients on antiretroviral therapy: 96 week results from an open-label, non-inferiority, randomized clinical trial (salt study). | we evaluated whether maintenance therapy with atazanavir/ritonavir plus lamivudine (atv/r + 3tc) was non-inferior to atv/r plus two nucleosides (atv/r + 2nucs) at 96 weeks of follow-up. | 2017 | 27629070 |
| seeksv: an accurate tool for somatic structural variation and virus integration detection. | many forms of variations exist in the human genome including single nucleotide polymorphism, small insert/deletion (del) (indel) and structural variation (sv). somatically acquired sv may regulate the expression of tumor-related genes and result in cell proliferation and uncontrolled growth, eventually inducing tumor formation. virus integration with host genome sequence is a type of sv that causes the related gene instability and normal cells to transform into tumor cells. cancer svs and viral ... | 2017 | 27634948 |
| in-house quantitative real-time pcr for the diagnosis of hepatitis b virus and hepatitis c virus infections. | the quantification of viral nucleic acids in serum by real-time pcr plays an important role in diagnosing hepatitis b virus and hepatitis c virus infection. in this study, we developed an assay using specific primers and probes to quantify hepatitis b virus dna or hepatitis c virus rna in serum from infected patients. for standardization and validation of the assay, an international panel of hepatitis b virus/hepatitis c virus and standard plasmids was used. a correlation coefficient of 0.983 an ... | 2017 | 27637170 |
| nonalcoholic fatty liver disease in asia: emerging perspectives. | as in the west, nonalcoholic fatty liver disease (nafld) is the commonest chronic liver disease in asia, with a prevalence higher than 40 % in some countries. the risk factors for nafld development are similar to those in western countries, including increased body mass index, diabetes, insulin resistance, and metabolic syndrome. nafld in asians is associated with different extrahepatic manifestations involving the cardiovascular, gastrointestinal, and renal systems. a considerable proportion of ... | 2017 | 27637587 |
| recent advancements in combination subunit vaccine development. | viral structural proteins share a common nature of homotypic interactions that drive viral capsid formation. this natural process has been mimicked in vitro through recombinant technology to generate various virus-like particles (vlps) and small subviral particles that exhibit similar structural and antigenic properties of their authentic viruses. therefore, such self-assembled, polyvalent, and highly immunogenic vlps and small subviral particles are excellent subunit vaccines against individual ... | 2017 | 27649319 |
| cell culture system for analysis of genetic heterogeneity within hepatocellular carcinomas and response to pharmacologic agents. | no targeted therapies have been found to be effective against hepatocellular carcinoma (hcc), possibly due to the large degree of intratumor heterogeneity. we performed genetic analyses of different regions of hccs to evaluate levels of intratumor heterogeneity and associate alterations with responses to different pharmacologic agents. | 2017 | 27639803 |
| evaluation of liver enzyme levels and identification of asymptomatic liver disease patients in primary care. | the evaluation of serum liver enzyme levels is the most used surrogate marker of liver injury in clinical practice. the prevalence and association of abnormal enzyme values with hepatitis b virus (hbv) and hepatitis c virus (hcv) infections, and with other major causes of liver damage (obesity, diabetes, dyslipidemia, and alcohol abuse) were evaluated in individuals attending the surgeries of 14 general practitioners (gps) working in messina. alanine-amino-transferase, aspartate-amino-transferas ... | 2017 | 27644706 |
| effects of amino acid substitutions in hepatitis b virus surface protein on virion secretion, antigenicity, hbsag and viral dna. | as important virological markers, serum hepatitis b surface antigen (hbsag) and hepatitis b virus (hbv) dna levels show large fluctuations among chronic hepatitis b patients. the aim of this study was to reveal the potential impact and mechanisms of amino acid substitutions in small hepatitis b surface proteins (shbs) on serum hbsag and hbv dna levels. | 2017 | 27650283 |
| hiv-infected or -exposed children exhibit lower immunogenicity to hepatitis b vaccine in yaoundé, cameroon: an appeal for revised policies in tropical settings? | since 2005, anti-hepatitis b virus (anti-hbv) vaccine is part of the expanded program on immunization (epi) for infants born in cameroon, with 99% anti-hbv coverage. in a context of generalized hiv epidemiology, we assessed paediatric anti-hbv vaccine response according to hiv status, feeding option and age in a tropical context. | 2017 | 27656883 |
| metavir and fib-4 scores are associated with patient prognosis after curative hepatectomy in hepatitis b virus-related hepatocellular carcinoma: a retrospective cohort study at two centers in china. | although metavir and fibrosis-4 (fib-4) scores are typically used to assess the severity of liver fibrosis, the relationship between these scores and patient outcome in hepatocellular carcinoma (hcc) is unclear. the aim of this study was to evaluate the prognostic value of the severity of hepatic fibrosis in hbv-related hcc patients after curative resection. we examined the prognostic roles of the metavir and preoperative fib-4 scores in 432 hbv-hcc patients who underwent curative resection at t ... | 2017 | 27662665 |
| no detectable resistance to tenofovir disoproxil fumarate in hbeag+ and hbeag- patients with chronic hepatitis b after 8 years of treatment. | a major hurdle in the long-term treatment of chronic hepatitis b (chb) patients is to maintain viral suppression in the absence of drug resistance. to date, no evidence of resistance to tenofovir disoproxil fumarate (tdf) has been observed. a cumulative evaluation of chb patients who qualified for resistance surveillance over 8 years of tdf treatment was conducted. patients in studies gs-us-174-0102 (hbeag-) and gs-us-174-0103 (hbeag+) were randomized 2:1 to receive tdf or adefovir dipivoxil (ad ... | 2017 | 27658343 |
| patients with hbv-related acute-on-chronic liver failure have increased concentrations of extracellular histones aggravating cellular damage and systemic inflammation. | acute-on-chronic liver failure (aclf) is the most common type of liver failure and associated with grave consequences. systemic inflammation has been linked to its pathogenesis and outcome, but the identifiable triggers are absent. recently, extracellular histones, especially h4, have been recognized as important mediators of cell damage in various inflammatory conditions. this study aimed to investigate whether extracellular histones have clinical implications in patients with hepatitis b virus ... | 2017 | 27660136 |
| mir-370 suppresses hbv gene expression and replication by targeting nuclear factor ia. | hepatitis b virus (hbv) infection is a major health problem worldwide. the roles of micrornas in the regulation of hbv expression are being increasingly recognized. in this study, we found that overexpression of mir-370 suppressed hbv gene expression and replication in huh7 cells, whereas antisense knockdown of endogenous mir-370 enhanced hbv gene expression and replication in huh7 cells and hepg2.2.15 cells. further, we identified the transcription factor nuclear factor ia (nfia) as a new host ... | 2017 | 27664977 |
| efficacy of prophylactic antiviral therapy and outcomes in hbsag-negative, anti-hbc-positive patients receiving chemotherapy: a real-life experience. | the aim of this study is to evaluate the outcomes of hepatitis b surface antigen (hbsag)-negative, anti-hbc-positive patients who received immunosuppressive therapies. | 2017 | 27669175 |
| estimation of heritability for nine common cancers using data from genome-wide association studies in chinese population. | the familial aggregation indicated the inheritance of cancer risk. recent genome-wide association studies (gwass) have identified a number of common single-nucleotide polymorphisms (snps). following heritability analyses have shown that snps could explain a moderate amount of variance for different cancer phenotypes among caucasians. however, little information was available in chinese population. we performed a genome-wide complex trait analysis for common cancers at nine anatomical sites in ch ... | 2017 | 27668986 |
| detection of different categories of hepatitis b virus (hbv) infection in a multi-regional study comparing the clinical sensitivity of hepatitis b surface antigen and hbv-dna testing. | twenty-two users of individual donation nucleic acid amplification technology (id-nat) in six geographical regions provided detailed hepatitis b virus (hbv) infection data in first-time, lapsed, and repeat donations and classified confirmed hbv-positive donors into different infection categories. these data were used to compare the clinical sensitivity of hepatitis b surface antigen (hbsag) and hbv-dna testing. | 2017 | 27673757 |
| plasma epstein-barr virus and hepatitis b virus in non-hodgkin lymphomas: two lymphotropic, potentially oncogenic, latently occurring dna viruses. | there is a need to study potential infective etiologies in lymphomas. lymphocyte-transforming viruses can directly infect lymphocytes, disrupt normal cell functions, and promote cell division. epstein-barr virus (ebv) is known to be associated with several lymphomas, especially hodgkin lymphomas (hls). and recently, the lymphocyte-transforming role of hepatitis b virus (hbv) has been emphasized. | 2017 | 27688607 |
| improvements in hepatitis b virus screening before rituximab therapy: a community-based, safety-net hospital experience. | individuals with chronic hepatitis b virus infection (hbv) or previously resolved hbv are at increased risk of hbv exacerbation or reactivation when they receive treatment with anti-cd20 monoclonal antibodies (against b-lymphocyte antigen cluster of differentiation 20 [cd20], an activated-glycosylated phosphoprotein) like rituximab (rtx). the objective of the current study was to evaluate the rates of appropriate hbv screening before patients started receiving rtx, at the initiation of hbv treat ... | 2017 | 27696389 |
| hepatocellular carcinoma in the absence of cirrhosis in patients with chronic hepatitis b virus infection. | cirrhosis related to chronic hepatitis b (chb) is a major risk factor for hepatocellular carcinoma (hcc). the extent to which hcc occurs in u.s. in the absence of cirrhosis in chb remains unclear. | 2017 | 27693539 |
| is the risk of death enhanced in immunosuppressed hepatitis b virus-infected patients who develop acute liver failure? | 2017 | 27693523 | |
| hbx and sp1 upregulate dkk1 expression. | numerous evidences suggested that the hepatitis b virus (hbv) was recognized as an important factor in the development of hepatocellular carcinoma (hcc). dickkopf-1 (dkk1) recently was reported to be involved in the progress of hcc. hbv may regulate dkk1 expression in hematoma carcinogenesis. here, we demonstrated that hbv could regulate dkk1 promoter activity which resulted in upregulation of its mrna and protein expression in several hbv existing cell lines, and hbx played a prominent role in ... | 2017 | 27723845 |
| development of the cpg adjuvant 1018: a case study. | the development of aluminum salts (alum) as vaccine adjuvants was an empirical process with little understanding of the mechanism of action and, with decades of use, it has become clear that there is a need for alternatives where alum-based adjuvants are suboptimal. oligonucleotides containing unmethylated cpg sequences represent one alternative as they are potent stimulators of the vertebrate innate immune system through activation of toll-like receptor-9. this chapter outlines the methods used ... | 2017 | 27718183 |
| characterization of hepatitis b virus infection in illicit drug users in the marajó archipelago, northern brazil. | south america is considered to have a low prevalence of hepatitis b virus (hbv) infection, although areas with a relatively high prevalence have been identified in northern brazil. few epidemiological studies of populations at risk of hbv infection are available for this region. given this, in the present study, we investigated the prevalence of hbv and the factors associated with infection among illicit drug users (dus) in the marajó archipelago, northern brazil. in this cross-sectional study, ... | 2017 | 27718074 |
| genetic basis of hepatitis virus-associated hepatocellular carcinoma: linkage between infection, inflammation, and tumorigenesis. | hepatitis virus infection is a leading cause of chronic liver disease, including cirrhosis and hepatocellular carcinoma (hcc). although anti-viral therapies against hepatitis b virus (hbv) and hepatitis c virus (hcv) have dramatically progressed during the past decade, the estimated number of people chronically infected with hbv and/or hcv is ~370 million, and hepatitis virus-associated hepatocarcinogenesis is a serious health concern worldwide. understanding the mechanism of virus-associated ca ... | 2017 | 27714455 |
| lamivudine and fingolimod co-administration in two patients with multiple sclerosis and occult hepatitis b virus infection. | 2017 | 27699497 | |
| serum hbv core-related antigen is a good predictor for spontaneous hbeag seroconversion in chronic hepatitis b patients. | early prediction of spontaneous hepatitis b virus e antigen (hbeag) seroconversion is pivotal in the prevention of unnecessary drug prescription, corresponding financial burden, and adverse reactions. one hundred and thirteen chronic hepatitis b patients with hbeag-positive in the immune active phase were followed up for about 1.5 years. patients were classified into two groups: spontaneous hbeag seroconversion group (group a, n = 18) and non-spontaneous hbeag seroconversion group. among the non ... | 2017 | 27505145 |
| interferon stimulated genes and innate immune activation following infection with hepatitis b and c viruses. | although not directly cytopathic, hepatitis b and c viruses (hbv and hcv) are responsible for millions of deaths per year, and the aging patient population presents a severe public health challenge. most cases of acute hcv become chronic, but treatment has become increasingly successful following the development of direct acting antiviral agents. conversely, most cases of acute hbv are cleared in the pre-symptomatic stage and do not become chronic, but treatment options for chronic hbv are limit ... | 2017 | 27509053 |
| tenofovir in treatment of iranian patients with chronic hepatitis b virus infection: an open-label case series. | tenofovir is among the first-line treatments for chronic hepatitis b (chb) virus infection. we evaluated the efficacy and safety of tenofovir in treatment of iranian patients with chb. | 2017 | 27512706 |
| telbivudine therapy for chronic hepatitis b: a journey to identify super-responders and to optimize treatment using the roadmap model. | hepatitis b virus (hbv) infection is one of the most serious health problems worldwide with a high risk for cirrhosis and liver cancer. several antiviral agents have been approved for the treatment of chronic hepatitis b, leading to a rapid reduction in hbv dna and normalization of serum alanine aminotransferase levels. telbivudine, a potent inhibitor of hbv replication, has been shown to be well tolerated. because of the emergence of drug resistance, optimization strategies for telbivudine ther ... | 2017 | 27515408 |
| management of clevudine-resistant chronic hepatitis b: a multicenter cohort study. | data are lacking regarding the management of chronic hepatitis b (chb) with resistance to clevudine (clv). this study evaluated the efficacy of different rescue therapies for clv-resistant chb. | 2017 | 27538443 |
| low risk of hepatitis b virus reactivation in patients with resolved infection and chronic myeloid leukemia treated with tyrosine kinase inhibitors. | 2017 | 27546591 | |
| tenofovir disoproxil fumarate (tdf) vs. emtricitabine (ftc)/tdf in lamivudine resistant hepatitis b: a 5-year randomised study. | long-term treatment with tenofovir disoproxil fumarate (tdf) alone, or in combination with emtricitabine (ftc) is associated with sustained viral suppression in patients with lamivudine resistant (lam-r) chronic hepatitis b (chb). | 2017 | 27545497 |
| refining the risk estimate for transfusion-transmission of occult hepatitis b virus. | we previously published a model to estimate the residual risk (rr) for occult hepatitis b infection (obi) in the absence of universal anti-hbc testing. to incorporate new information on the epidemiology of obi, we describe model refinements and estimate a more accurate hbv rr due to obi in australia. | 2017 | 27564651 |
| a model predicting survival of patients with recurrent or progressive hepatocellular carcinoma: the more score. | most prognostic models for hepatocellular carcinoma are based on data at the time of diagnosis. however, the disease frequently recurs or progresses after initial treatment, with changes in tumor burden and clinical status. therefore, we developed a risk score model to predict survival of hepatocellular carcinoma patients at the time of disease recurrence or progression. | 2017 | 27519171 |
| persistently elevated circulating th22 reversely correlates with prognosis in hbv-related acute-on-chronic liver failure. | hepatitis b virus-related acute-on-chronic liver failure (hbv-aclf) is an acute deterioration of liver function on chronic liver disease with immune disorder. th22 cells and il-22 were correlated with inflammatory and autoimmune diseases. however, th22 cells and il-22 in the pathogenesis of hbv-aclf remains to be elucidated. it was investigated the correlation between th22 and prognosis in hbv-aclf. | 2017 | 27548078 |
| concurrent fatty liver increases risk of hepatocellular carcinoma among patients with chronic hepatitis b. | concurrent fatty liver in hepatitis b virus (hbv)-infected patients without significant alcohol intake is a frequent and increasingly alarming problem because of the non-alcoholic fatty liver disease pandemic. the risk of hbv-related hepatocellular carcinoma (hcc) development was increased by concomitant obesity and diabetes. direct evidence of the hepatocarcinogenic effect of fatty liver in chronic hbv remains elusive. we aimed to evaluate the risk of concurrent histologically proven fatty live ... | 2017 | 27547913 |
| review of laboratory tests used in monitoring hepatitis b response to pegylated interferon and nucleos(t)ide analog therapy. | there are only two currently approved classes of hepatitis b virus (hbv) antiviral agents, pegylated interferon (peg-ifn), and nucleos(t)ide analogs (nas) for chronic hbv infection. although peg-ifn is used for a finite 48-week duration and offers a greater chance of sustained off-treatment virological response, it is poorly tolerated and can only be offered to selected patients. the nas are well tolerated but require prolonged therapy due to risk of relapse with treatment cessation. there is ev ... | 2017 | 27547127 |
| hepatitis b virus and hepatitis d virus recurrence in patients undergoing liver transplantation for hepatitis b virus and hepatitis b virus plus hepatitis d virus. | in this study, we retrospectively analyzed the recurrence of hepatitis b virus (hbv) and hepatitis d virus (hdv) infection after liver transplantation for hbv and hbv+hdv co-infection. | 2017 | 27569956 |
| safety of monitoring viral and liver function markers in patients with prior resolved hepatitis b infection after kidney transplantation. | hepatitis b virus (hbv) infection is a risk factor of mortality in kidney transplant recipients. however, information on the risk of hbv reactivation in kidney recipients with prior resolved hbv infection is limited. this study aimed to evaluate the safety of simply monitoring viral and liver markers in living donor kidney transplantation (ldkt) recipients with prior resolved hbv infection. | 2017 | 27569942 |
| week 4 viral load predicts long-term suppression of hepatitis b virus dna during antiviral therapy: improving hepatitis b treatment in the real world. | entecavir and tenofovir potently suppress hepatitis b virus (hbv) replication so that serum hbv dna levels <20 iu/ml can be achieved after 2 years. despite this, inadequate suppression is reported in >20% of cases for unclear reasons. | 2017 | 27571991 |
| the role of quantitative hepatitis b surface antigen revisited. | in the past 10years, there has been a lot of enthusiasm surrounding the use of serum hepatitis b surface antigen (hbsag) quantification to predict disease activity and monitor treatment response in chronic hepatitis b. the measurement of hbsag levels have been standardized in iu/ml, and nowadays it is almost a mandatory measurement due to the development of new antiviral treatments aiming at hbsag seroclearance, i.e., functional cure of hepatitis b. recently, there has been an improved understan ... | 2017 | 27575311 |
| avcpred: an integrated web server for prediction and design of antiviral compounds. | viral infections constantly jeopardize the global public health due to lack of effective antiviral therapeutics. therefore, there is an imperative need to speed up the drug discovery process to identify novel and efficient drug candidates. in this study, we have developed quantitative structure-activity relationship (qsar)-based models for predicting antiviral compounds (avcs) against deadly viruses like human immunodeficiency virus (hiv), hepatitis c virus (hcv), hepatitis b virus (hbv), human ... | 2017 | 27490990 |
| novel function of the endoplasmic reticulum degradation-enhancing α-mannosidase-like proteins in the human hepatitis b virus life cycle, mediated by the middle envelope protein. | cells replicating the human hepatitis b virus (hbv) express high levels of degradation-enhancing α-mannosidase-like proteins (edems), a family of proteins involved in the endoplasmic reticulum associated degradation, one of the pathways activated during the unfolded protein response. owing to their α-1,2 mannosidase activity, the edem1-3 proteins are able to process the n-linked glycans of misfolded or incompletely folded proteins, providing the recognition signal for their subsequent degradatio ... | 2017 | 27490136 |
| conventional versus drug-eluting beads chemoembolization for hepatocellular carcinoma: emphasis on the impact of tumor size. | this study aims to evaluate clinical outcomes of patients with hepatocellular carcinoma who underwent transarterial chemoembolization (tace) using drug-eluting beads (deb). | 2017 | 27503585 |
| evolutionary dynamics of hbv-d7 subgenotype in tunisia. | hepatitis b virus (hbv) is the main cause of diseases liver related infecting more than 200 milion persons worldwide. hbv infection shows high level of prevalence in south-east europe and in mediterranean basin. in tunisia, a country with an intermediate level endemicity, hbsag prevalence ranges from 2 to 5%. most of the hbv isolates from tunisia were classified as subgenotype d7 whose circulation is restricted to a specific area of north africa including maghreb region. in this paper, the phylo ... | 2017 | 27543368 |
| hav and hbv seroprevalence in 1,000 patients with chronic hcv infection in a tertiary care center in são paulo, brazil. | background. patients with chronic hcv infection and superinfection by hepatitis a virus (hav) or hepatitis b virus (hbv) have higher morbidity and mortality when compared with those without hcv infection. therefore, hav and hbv active immunization has become mandatory in this population and hence their serological markers must be determined. the aim of this study was to evaluate the prevalence of serological markers of hav and hbv infection in patients with chronic hcv. | 2017 | 27493107 |
| economic growth leads to increase of obesity and associated hepatocellular carcinoma in developing countries. | hepatocellular carcinoma (hcc) is the most common type of primary liver cancer and the third leading cause of cancer related death worldwide. in recent years, the prevalence of hcc has increased in both developing and developed countries. most hcc cases develop in the presence of advanced chronic liver disease related to viral hepatitis. in particular hepatitis b virus and hepatitis c virus infections are considered as major hcc risk factors worldwide. however, current studies provide strong evi ... | 2017 | 27493104 |
| a case of figurate urticaria by etanercept. | etanercept is a competitive inhibitor of tumor necrosis factor-alpha (tnf-α) a polypeptide hormone, involved in the development of the immune system, in host defense and immune surveillance. even if the etanercept mechanism of action is not completely understood, it is supposed that it negatively modulates biological responses mediated by molecules (cytokines, adhesion molecules, or proteinases) induced or regulated by tnf. for this reason, it is widely used in the treatment of immunologicals di ... | 2017 | 27440958 |
| novel and highly sensitive immunoassay for total hepatitis b surface antigen, including that complexed with hepatitis b surface antibody. | hepatitis b surface antigen (hbsag) is used as a clinical marker of hepatitis b virus (hbv) infection. however, conventional hbsag assays have so far failed to accurately detect hbsag in blood because of interference by patient-derived antibodies against hbsag (hbsab). | 2017 | 27460099 |
| hepatitis b virus x protein impairs α-interferon signaling via up-regulation of suppressor of cytokine signaling 3 and protein phosphatase 2a. | hepatitis b virus (hbv) causes liver cirrhosis and hepatocellular carcinoma. standard therapy includes treatment with interferon (ifn); however, its efficacy is limited. hbv has been reported to impair ifn signaling; however, the mechanism is unclear. here, the relationship between hbv x protein (hbx) and ifn signaling was investigated by establishing hepg2 cells, stably expressing hbx (hepg2/hbx) via retrovirus-mediated gene transfer. subsequently, ifn negative-regulator expression and its mech ... | 2017 | 27459003 |
| evaluation of liaison® xl system for hbsag, and anti-hcv and anti-hiv/ag p24. | the aim of this study was to compare the data obtained using the new liaison® xl chemiluminescence system to search for hbsag, anti-hcv, and anti-hiv1-2/p24 ag with those obtained using the vitros system currently adopted by the microbiology unit of the hospital of legnano. routine samples of patients who were referred by practitioners for the determination of hbsag (1,000 samples) and/or anti-hcv (1,002 samples) and/or anti-hiv1-2 (995 samples) were simultaneously analyzed using both systems. t ... | 2017 | 27467710 |
| influence of treg cells and hbv genotype on sustained response and drug resistance in the treatment with nucleoside drugs. | we aimed to investigate the influence of regulatory t cells including cd4+cd25+, cd8+cd28- and hepatitis b virus (hbv) genotype on sustained virological response and tolerance of nucleoside drugs. one hundred and thirty-seven patients were enrolled. lamivudine was administered to 84 patients. entecavir was administered to the other 53 patients. before treatment, biochemical tests, hbv dna load, hbv serum level, hbv genotype, pb cd3+, cd4+, cd8+, cd4+cd25+/cd3+, and cd8+cd28-/cd3+ frequencies wer ... | 2017 | 28273209 |
| hepatitis b, c, and d virus infection showing distinct patterns between injection drug users and the general population. | hepatitis b, c, and d virus (hbv, hcv, and hdv) infections are known to be prevalent in injection drug users (idus); however, the relationship between the molecular epidemiologic features of hepatitis virus infection in high-risk individuals and the general population has not yet been established. | 2017 | 27248508 |
| predominance of hepatitis b virus genotype a among treated hiv infected patients experiencing high hbv drug resistance in nairobi, kenya. | hbv/hiv coinfections are becoming common with information on hbv genetic diversity and drug resistance still remaining elusive. to evaluate the hbv genetic diversity and drug resistance associated mutations among drug experienced hiv patients, the genetic analysis of the partial hbv-pol-reverse trancriptase gene was successfully sequenced from 13 samples. analysis of the sequences showed that all (13) the sequences belonged to genotype a. nucleos(t)ide drug resistance mutations were found in six ... | 2017 | 28316253 |
| natural history of chronic hepatitis b virus infection in children in japan: a comparison of mother-to-child transmission with horizontal transmission. | it is necessary to evaluate the natural history of children with hepatitis b virus (hbv) infection in each country to consider their long-term management. | 2017 | 28184998 |
| low and disparate seroprotection after pentavalent childhood vaccination in the lao people's democratic republic: a cross-sectional study. | in lao people's democratic republic, the high burden of vaccine-preventable diseases is thought to be mainly due to low vaccine coverage. we investigated the seroprotective response against diphtheria-tetanus-whole cell pertussis-hepatitis b-haemophilus influenzae type b (dtpw-hepb-hib) vaccine in children. | 2017 | 27756713 |
| human leukocyte antigen-e alleles are associated with hepatitis c virus, torque teno virus, and toxoplasma co-infections but are not associated with hepatitis b virus, hepatitis d virus, and gb virus c co-infections in human immunodeficiency virus patients. | data regarding the distribution of human leukocyte antigen (hla)-e alleles and their association with blood-borne pathogen infections/co-infections are limited for many populations, including indonesia. | 2017 | 27293362 |
| molecular analysis of hepatitis b virus sub-genotypes and incidence of pres1/pres2 region mutations in hbv-infected egyptian patients from mansoura. | hepatitis b virus (hbv) is one of the major causes of viral hepatitis worldwide. despite the prevalence of hbv infection in egypt, few studies have focused on sub-genotyping of the virus. moreover, no studies are available regarding the mutational analysis of the pres1/pres2 region of the viral genome, or its impact on hepatocellular carcinoma (hcc) development in egypt. in this study, we have analyzed the sub-genotypes and incidence of mutations in the pres1/pres2 region of hbv present in hbv-i ... | 2017 | 28390175 |
| a pilot study of salivary n-glycome in hbv-induced chronic hepatitis, cirrhosis, and hepatocellular carcinoma. | hepatitis b is a potentially life-threatening liver infection caused by the hepatitis b virus (hbv), which can lead to chronic liver disease and put people at high risk of death from cirrhosis of the liver and liver cancer. however, little is known about the correlation of salivary n-linked glycans related to hbv-infected liver diseases. here we investigated n-linked glycome in saliva from 200 subjects (50 healthy volunteers (hv), 40 hbv-infected patients (hb), 50 cirrhosis patients (hc), and 60 ... | 2017 | 28389847 |
| assessing hepatitis b knowledge among immigrant communities in new york city. | the objective of this study was to assess the knowledge of hepatitis b virus (hbv) among new york city immigrants. data were obtained from cohort of 2385 persons at-risk for hbv, who completed a knowledge assessment survey during hbv screening events in 2010-2013. hbv knowledge scores were very low among the tested population, with the majority answering every question incorrectly. participants had higher odds of obtaining a better score if they were fluent in english or born in the us, where pa ... | 2017 | 28389832 |
| hbxip overexpression is correlated with the clinical features and survival outcome of ovarian cancer. | accumulated evidence has demonstrated that mammalian hepatitis b x-interacting protein (hbxip) has broad roles in cancer. although hbxip is associated with a variety of cancers, the hbxip protein expression level and its clinical significance in ovarian cancer have not yet been determined. the aim of this study is to investigate the association between hbxip expression and the clinicopathological features of ovarian cancer patients to determine whether hbxip may be correlated with a poor prognos ... | 2017 | 28388957 |
| high sero-prevalence of hepatitis b virus and human immunodeficiency virus infections among pregnant women attending antenatal clinic at temeke municipal health facilities, dar es salaam, tanzania: a cross sectional study. | hepatitis b virus (hbv) and human immunodeficiency virus (hiv) infection in pregnancy is associated with direct effect of pregnancy and potential viral transmission from mother to newborn. in tanzania very little in known on prevalence of hbv infection and their associated factors among pregnant women in lower health facilities. the main objective of the study was to determine the prevalence of hbsag, hiv and hbv-hiv co-infection among pregnant women attending antenatal clinics in dar es salaam. | 2017 | 28388879 |
| immune balance in hepatitis b infection: present and future therapies. | chronic hepatitis b virus (hbv) infection affects millions of people worldwide and about half a million people die every year. india represents the second largest pool of chronic hbv infections with an estimated 40 million chronically infected patients. persistence or clearance of hbv infection mainly depends upon host immune responses. chronically infected individuals remain in immune tolerant phase unless hbv flares and leads to development of chronic active hepatitis or acute on chronic liver ... | 2017 | 28387980 |
| elevated expression of chemokine cxcl13 in chronic hepatitis b patients links to immune control during antiviral therapy. | c-x-c-chemokine ligand 13 (cxcl13), the ligand for c-x-c chemokine receptor type 5 (cxcr5), is a major regulator of b-cell trafficking and plays an integral role in age-dependent clearance of hepatitis b virus (hbv) in the mouse model. however, the expression and function of cxcl13 in patients with chronic hepatitis b (chb) remain unknown. by use of liver cell subpopulations isolated from chb patients, we found that cxcl13 mrna was abundantly expressed in kupffer cells (kcs), but not in primary ... | 2017 | 28386259 |
| evolution of full-length genomes of hbv quasispecies in sera of patients with a coexistence of hbsag and anti-hbs antibodies. | although the evolutionary changes of viral quasispecies are correlated to the pathological status of a disease, little is known in the coexistence of hepatitis b surface antigen (hbsag) and antibodies to these antigens (anti-hbs). to examine evolutionary changes in hepatitis b virus (hbv) and their relationship to the coexistence of hbsag and anti-hbs antibodies, hbv genomes in patients with a coexistence of hbsag and anti-hbs antibodies (experimental group) and hbsag positive without anti-hbs ( ... | 2017 | 28386078 |
| inhibitory effects of resveratrol on hepatitis b virus x-protein (hbx)-induced hepatocellular carcinoma (hcc). | liver cancer occurs very frequently worldwide and hepatocellular carcinoma (hcc) accounts for more than 80% of total primary liver cancer cases. here, the anticarcinogenic effects of resveratrol against hepatitis b virus (hbv)-induced hcc were investigated using hbv x-protein-overexpressing huh7 (huh7-hbx) human hepatoma cells. mtt assay showed that resveratrol decreased cell viability. fluorescence-activated cell sorter analysis showed that it induced g1 cell cycle arrest without increasing the ... | 2017 | 28385009 |
| a novel system for predicting liver histopathology in patients with chronic hepatitis b. | there is currently a lack of reliable, reproducible, and easily applied methods for assessing changes in liver histology in patients in the gray zone phase of chronic hepatitis b (chb). therefore, we aimed to develop a novel predictive scoring system to detect significant liver histological changes in these patients.a total of 388 patients in the gray zone phase of chb who underwent liver biopsy were divided into a training group and a validation group, and their clinical and routinely available ... | 2017 | 28383410 |
| past, current, and future developments of therapeutic agents for treatment of chronic hepatitis b virus infection. | for decades, treatment of hepatitis b virus (hbv) infection has been relying on interferon (ifn)-based therapies and nucleoside/nucleotide analogs (nas) that selectively target the viral polymerase reverse transcriptase (rt) domain and thereby disrupt hbv viral dna synthesis. we have summarized here the key steps in the hbv viral life cycle, which could potentially be targeted by novel anti-hbv therapeutics. a wide range of next generation direct antiviral agents (daas) with distinct mechanisms ... | 2017 | 28383274 |
| transbody against virus core protein potently inhibits hepadnavirus replication in vivo: evidence from a duck model of hepatitis b virus. | 2017 | 28383135 | |
| the clinical efficacy and adverse effects of interferon combined with matrine in chronic hepatitis b: a systematic review and meta-analysis. | currently, many studies have demonstrated certain beneficial effects of interferon (ifn) combined with matrine (mat) for chronic hepatitis b (chb) in china. however, the evidence from these randomized control trials is still controversial. therefore, the aim of this meta-analysis was to explore the efficacy and safety of mat combined with ifn for chb. we performed a systematic search of seven databases to identify all randomized controlled trials that treated chb with ifn or ifn plus mat from th ... | 2017 | 28382770 |
| removal of integrated hepatitis b virus dna using crispr-cas9. | the presence of hepatitis b virus (hbv) covalently closed circular dna (cccdna) and the permanent integration of hbv dna into the host genome confers the risk of viral reactivation and hepatocellular carcinoma. nucleoside/nucleotide analogs alone have little or no capacity to eliminate replicative hbv templates consisting of cccdna or integrated hbv dna. recently, crispr/cas9 technology has been widely applied as a promising genome-editing tool, and hbv-specific crispr-cas9 systems were shown to ... | 2017 | 28382278 |
| a consensus for occupational health management of healthcare workers infected with human immunodeficiency virus, hepatitis b virus, and/or hepatitis c virus. | occupational health management plays an important role in the prevention of provider-to-patient transmission in healthcare workers infected with human immunodeficiency virus (hiv), hepatitis b virus (hbv), and/or hepatitis c virus (hcv). therefore, the japan society for occupational health's scientific committee of occupational health for health care workers has proposed a consensus for the management of healthcare workers infected with hiv, hbv, and/or hcv based on recent evidence for each conc ... | 2017 | 28381816 |
| occult hepatitis b virus infection in hyperlipidemia patients. | chronic hepatitis b virus (hbv) infection is associated with lower prevalence of hyperlipidemia (hlp). however, occult hbv infection (obi) in hlp patients has not yet been explored. obi is defined as the presence of detectable hbv dna in serum or liver tissue but undetectable hbv surface antigen in serum. in this study, 1,036 hlp patients and 1,134 replacement blood donor controls were recruited. among them, 252 hlp patients and 255 blood donors with antibody to hbv core positive were selected a ... | 2017 | 28381700 |
| topic: "the level of nurses' knowledge on occupational post exposure to hepatitis b infection in the tamale metropolis, ghana". | health care workers especially nurses in developing countries are at serious risk for infection from blood-borne pathogens particularly hepatitis b virus (hbv) - because of the high prevalence of such pathogens in many poorer regions of the world. employers are required to establish exposure-control plans that include post exposure follow-up for their employees and to comply with incident reporting requirements. this study assessed the level of knowledge and awareness of nurses in the tamale met ... | 2017 | 28381257 |
| a single center analysis of the positivity of hepatitis b antibody after neonatal vaccination program in korea. | the antibody to hepatitis b surface antigen (anti-hbs) seropositivity rate after 3 doses of hepatitis b virus (hbv) vaccination during infancy period is known to be higher than 90%. however, a considerable number of vaccines do not form protective anti-hbs or chronologic decrease of anti-hbs. we retrospectively collected data of hbv serologic test results in 20,738 individuals from 2000 to 2015. after exclusion criteria were applied, 19,072 individuals were included. we analyzed the anti-hbs ser ... | 2017 | 28378555 |
| acute infectious hepatitis in hospitalised children: a british paediatric surveillance unit study. | hepatitis remains a key public health priority globally. most childhood cases are caused by viruses, especially hepatitis a virus (hav) and hepatitis b virus (hbv). this study aimed to estimate the burden of acute infectious hepatitis in hospitalised children and to describe their clinical characteristics and outcomes. | 2017 | 28377449 |
| antiviral efficacy of entecavir for hepatitis b virus rta181v/t mutants. | the amino acid substitution at position 181 of the hepatitis b virus (hbv) polymerase is a multi-drug resistance affecting both the l-nucleoside and acyclic phosphonate nucleotide groups. data is limited on the efficacy of entecavir (etv) rescuing chronic hepatitis b (chb) patients with rta181t/v mutation. | 2017 | 28376852 |
| incidence and clinical characteristics of hepatitis b virus reactivation in hbsag-negative/hbcab-positive patients receiving rituximab for rheumatoid arthritis. | to analyse the incidence, clinical characteristics, and prognosis of patients with rheumatoid arthritis (ra) and hepatitis b virus (hbv) surface antigen negative/core antibody positive serostatus (hbsag-/hbcab+), who underwent rituximab therapy and developed hbv reactivation. | 2017 | 28375829 |
| the impact of hepatitis b virus infection and vaccination on the development of non-hodgkin lymphoma. | hepatitis b virus (hbv) infection has been documented as a risk factor for non-hodgkin lymphoma (nhl). however, there are few large cohort studies, and there is no report about the impact of hbv vaccination. we conducted this study to evaluate these issues. | 2017 | 28375587 |
| higher disappearance rate of anti-hbs in taiwanese freshers neonatally vaccinated with recombinant yeast hepatitis b vaccine. | to compare the long term efficacy of infant recombinant yeast hepatitis b vaccine (recombinant group) and infant plasma-derived one (plasma group) in taiwanese freshers. | 2017 | 28374906 |
| improvement of liver fibrosis after long-term antiviral therapy assessed by fibroscan in chronic hepatitis b patients with advanced fibrosis. | performing repeated liver biopsies to assess the improvement of liver fibrosis is impractical. the purpose of this prospective cohort study was to assess the improvement of liver fibrosis during antiviral treatment by serial liver stiffness (ls) measurement using fibroscan in chronic hepatitis b (chb) patients with advanced fibrosis. | 2017 | 28374814 |
| human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis b virus infection. | in order to understand the life cycle of hepatitis b virus (hbv) and to develop efficient anti-hbv drugs, a useful in vitro cell culture system which allows hbv infection and recapitulates virus-host interactions is essential; however, pre-existing in vitro hbv infection models are often problematic. here, we examined the potential of human induced-pluripotent stem (ips) cell-derived hepatocyte-like cells (ips-hlcs) as an in vitro hbv infection model. expression levels of several genes involved ... | 2017 | 28374759 |
| increased erp57 expression in hbv-related hepatocellular carcinoma: possible correlation and prognosis. | aim. erp57 is involved in virus induced endoplasmic reticulum stress (ers) and plays an important role in tumorigenesis. this study aimed to find whether hbv infection altered erp57 expression and whether erp57 regulation was involved in hepatitis b virus-related hepatocellular carcinoma (hbv-hcc) genesis. materials and methods. hbv-hcc tissues, chronic hepatitis b (chb) liver tissues, and normal liver tissues were acquired. erp57 expressions in these tissues were detected through immunohistoche ... | 2017 | 28373975 |
| prevalence and influencing factors of hepatitis b among a rural residential population in zhejiang province, china: a cross-sectional study. | to reveal the prevalence and associated influencing factors of hepatitis b among a rural residential population in zhejiang, china, in order to help develop specific control strategies. | 2017 | 28373257 |
| development of a novel site-specific pegylated interferon beta for antiviral therapy for chronic hepatitis b. | although nucleot(s)ide analogues and pegylated-interferon-α2a (peg-ifnα2a) can suppress hepatitis b virus (hbv) replication, it is difficult to achieve complete hbv elimination from hepatocytes. a novel site-specific pegylated recombinant human ifnβ (trk-560) was recently developed. in the present study, we evaluated the antiviral effects of trk-560 on hbv replication in vitro and in vivoin vitro and in vivo hbv replication models were treated with antivirals including trk-560, and changes in hb ... | 2017 | 28373196 |
| sequence analysis and functional characterization of full-length hepatitis b virus genomes from korean cirrhotic patients with or without liver cancer. | this study aimed to identify and characterize mutations in the hepatitis b virus (hbv) genome associated with advanced liver diseases. the 3.2-kb hbv genome of the c2 subgenotype was amplified from sera of 18 cirrhotic korean patients with (10) or without (8) hepatocellular carcinoma (hcc), and two clones per patient were characterized by transient transfection experiments in human hepatoma cells. while a1762t/g1764a core promoter mutations were highly prevalent in both groups, the g1896a precor ... | 2017 | 28373061 |
| clinical and pathological significance of myeloid differentiation factor 88 expression in human hepatocellular carcinoma tissues. | the innate immune system, which includes toll-like receptor (tlr) signaling, plays an important role in inflammation and oncogenesis. although tlr common adaptor myeloid differentiation factor 88 (myd88) is known to have multiple effects on carcinogenesis, the role of myd88 in hepatocarcinogenesis remains unknown. in this study, myd88 expression was examined in 105 samples of human hepatocellular carcinoma (hcc) tissue by immunohistochemistry, western blot, and quantitative reverse-transcriptase ... | 2017 | 28370778 |
| pregnancy and maternal chronic hepatitis b infection-evidence of reproductive advantage? | as multiparas have high prevalence of chronic hepatitis b virus (hbv) infection, we examined here the relationship between the number of pregnancies with hbv infection. | 2017 | 28370686 |
| monotherapy with tenofovir disoproxil fumarate for multiple drug-resistant chronic hepatitis b: 3-year trial. | combination therapy has been recommended for the treatment of patients harboring multiple drug-resistant hepatitis b virus (hbv). however, we recently demonstrated that monotherapy with tenofovir disoproxil fumarate (tdf) for 48 weeks displayed non-inferior efficacy to tdf plus entecavir (etv) combination therapy in patients with hbv resistant to multiple drugs, including etv and adefovir, respectively. nonetheless, whether prolonged tdf monotherapy would be safe and increase the virologic respon ... | 2017 | 28370419 |
| allogeneic bone marrow-derived mesenchymal stromal cells for hbv-related acute-on-chronic liver failure: a randomized controlled trial. | mortality from hepatitis b virus (hbv)-related acute-on-chronic liver failure (aclf) is high due to limited treatment options. preclinical and clinical investigations have proved that treatment with mesenchymal stromal cells (mscs) is beneficial for recovery from liver injury. we hypothesized that the outcome of hbv-related aclf would be improved by msc treatment. from 2010 to 2013, 110 patients with hbv-related aclf were enrolled in this open label non-blinded randomized controlled study. the c ... | 2017 | 28370357 |