Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| [antiviral therapy in the third trimester to prevent mother-to-infant transmission of hepatitis b virus:benefit or harm?] | 2017 | 28253569 | |
| variation in the viral hepatitis and hiv policies and practices of methadone maintenance programs. | patients prescribed methadone maintenance treatment (mmt) demonstrate elevated prevalence of hepatitis b virus (hbv), hepatitis c virus, and hiv. government agencies recommend testing for these infections in mmt programs, but uptake is limited. | 2017 | 28252455 |
| enhanced fluorescence elisa based on hat triggering fluorescence "turn-on" with enzyme-antibody dual labeled aunp probes for ultrasensitive detection of afp and hbsag. | at present, enzyme-linked immunosorbent assay (elisa) is considered to be the most appropriate approach in clinical biomarker detection, with good specificity, low cost, and straightforward readout. however, unsatisfactory sensitivity severely hampers its wide application in clinical diagnosis. herein, we designed a new kind of enhanced fluorescence enzyme-linked immunosorbent assay (felisa) based on the human alpha-thrombin (hat) triggering fluorescence "turn-on" signals. in this system, detect ... | 2017 | 28252291 |
| fibrosis assessment in patients with chronic hepatitis b virus (hbv) infection. | chronic hepatitis b virus (hbv) infection is a major cause of liver morbidity and mortality worldwide. while a proportion of the 250 million individuals chronically infected with hbv will not come to significant harm or require therapy, many others risk developing complications of the end-stage liver disease such as decompensated cirrhosis and hepatocellular carcinoma (hcc), without intervention. due to the complex natural history of hbv infection, patients require an expert assessment to interp ... | 2017 | 28251119 |
| optimizing antiviral agents for hepatitis b management in malignant lymphomas. | the global scale of hepatitis b infection is well known but its impact is still being understood. missed hepatitis b infection impacts lymphoma therapy especially increased risk of hepatitis b virus (hbv) reactivation and poor treatment outcomes. the presence of undiagnosed chronic hepatitis also undermines chronic hbv screening methods that are based on a positive hbsag alone. the goal of this review is to evaluate the literature for optimizing antiviral therapy for lymphoma patients with hbv i ... | 2017 | 28251118 |
| pediatric hepatitis b treatment. | although the introduction of hepatitis b vaccine has been contributing to the reduction in the prevalence of hepatitis b virus (hbv) carriers worldwide, the treatment of children with chronic hbv infection is a challenge to be addressed. hbeag seroconversion, which induces low replication of hbv, is widely accepted as the first goal of antiviral treatment in children with chronic hepatitis b. however, spontaneous hbeag seroconversion is highly expected in children with chronic hbv infection. the ... | 2017 | 28251116 |
| quantitative nucleic acid amplification methods and their implications in clinical virology. | recently, a number of techniques have been approved for quantification of viral nucleic acids in clinical samples. viral load (vl) tests have considerable importance in the management of patients and are widely used in routine diagnosis. in clinical virology, vl testing are important to monitor the antiviral treatment, to initiate preemptive therapy, to understand pathogenesis, and to evaluate the infectivity. these tests have now become a part of many diagnostic and treatment guidelines. consid ... | 2017 | 28251100 |
| potential of cannabidiol for the treatment of viral hepatitis. | viral hepatitis b (hbv) and hepatitis c (hcv) pose a major health problem globally and if untreated, both viruses lead to severe liver damage resulting in liver cirrhosis and cancer. while hbv has a vaccine, hcv has none at the moment. the risk of drug resistance, combined with the high cost of current therapies, makes it a necessity for cost-effective therapeutics to be discovered and developed. the recent surge in interest in medical cannabis has led to interest in evaluating and validating th ... | 2017 | 28250664 |
| serum lipid profile as a marker of liver impairment in hepatitis b cirrhosis patients. | chronic hbv infection is a major cause of cirrhosis and an important risk factor to develop hepatocellular carcinoma. the study is conducted to find out the changes in the lipid metabolism of hbv-cirrhosis patients. | 2017 | 28249586 |
| reactivation of occult hbv infection in an hiv/hcv co-infected patient successfully treated with sofosbuvir/ledipasvir: a case report and review of the literature. | reactivation of occult or inactive hepatitis b virus (hbv) infection during immunosuppressant treatments is well known and widely described in literature. the same observation has been made in hepatitis c (hcv)-infected patients previously exposed to hbv and treated with interferon-free daa treatments. because of common transmission routes, persons may have been exposed to hcv, hbv and hiv, but few cases have been reported in this scenario to date. frequency of hbv reactivation in hiv/hcv co-inf ... | 2017 | 28249574 |
| evaluation of two vidas (®)prototypes for detecting anti-hev igg. | high performance anti-hepatitis e virus (hev) igg assays are crucial for epidemiology. | 2017 | 28249234 |
| the independent predictors of significant liver histological changes in chronic hepatitis b virus infection patients with persistently high-normal or low-normal alanine transaminase levels. | to determine the independent predictors of significant liver histological changes (slhc) defined as inflammatory grade ≥a2 and/or fibrosis stage ≥f2 using the metavir scoring system in chronic hepatitis b virus (hbv) infection patients with persistently normal alt (pnalt) levels. | 2017 | 28245424 |
| a mathematical model for estimating residual transmission risk of occult hepatitis b virus infection with different blood safety scenarios. | if anti-hepatitis b core antibody testing is not mandated blood donors with occult hepatitis b infection (obi) may transmit hepatitis b virus (hbv) to a recipient in spite of the use of nucleic acid amplification technology (nat) or pathogen inactivation (pi). | 2017 | 28244600 |
| efficacy and safety analysis of rituximab combined with chemotherapy in the treatment of b-cell lymphoma patients complicated with hepatitis b virus infection. | lymphoma combined with hepatitis b infection occupies a relatively higher incidence in china than that of in europe and america. | 2017 | 28244480 |
| pharmaceutical approval update. | prasterone (intrarosa) for the treatment of dyspareunia due to menopause; crisaborole (eucrisa) for the topical treatment of atopic dermatitis; and tenofovir alafenamide (vemlidy) for once-daily treatment of chronic hepatitis b virus infection. | 2017 | 28163553 |
| anti-pd-1/pd-l1 therapy for infectious diseases: learning from the cancer paradigm. | immune checkpoint pathways regulate optimal host immune responses against transformed cells, induce immunological memory, and limit tissue pathology. conversely, aberrant immune checkpoint activity signifies a poor prognosis in cancer and infectious diseases. host-directed therapy (hdt) via immune checkpoint blockade has revolutionized cancer treatment with therapeutic implications for chronic infections, thus laying the foundation for this review. | 2017 | 28163164 |
| autoimmune hepatitis and occult hcv infection: a prospective single-centre clinical study. | 2017 | 28161557 | |
| short-course tocilizumab increases risk of hepatitis b virus reactivation in patients with rheumatoid arthritis: a prospective clinical observation. | to investigate the impact of short-course tocilizumab (tcz) on hepatitis b virus (hbv) reactivation in rheumatoid arthritis (ra) patients. | 2017 | 28160426 |
| clinical characteristics and prognosis of non-b, non-c hepatocellular carcinoma: the impact of patient sex on disease-free survival - a retrospective cohort study. | the number of patients with hepatocellular carcinoma (hcc) negative for both hepatitis b virus surface antigen (hbsag) and hepatitis c virus antibody (hcvab) has increased recently. the purpose of the present study was to investigate the clinical characteristics and prognoses of non-b non-c hcc (nbnc-hcc) patients. | 2017 | 28159713 |
| cxcr5(+) cd8(+) t cells indirectly offer b cell help and are inversely correlated with viral load in chronic hepatitis b infection. | treatment options for chronic hepatitis b (chb) infection are extremely limited. cxcr5(+) cd8(+) t cell is a novel cell subtype and could possess strong cytotoxic properties in hiv infection. in this study, we investigated the role of cxcr5(+) cd8(+) t cells in chb patients. compared to healthy individuals, both chb patients and hepatitis b virus (hbv)-infected hepatocellular carcinoma patients presented significant upregulation of cxcr5(+) cd8(+) t cells in peripheral blood, in which cxcr5(+) c ... | 2017 | 28157399 |
| epidemiology of hepatitis b virus in immigrants crossing to europe from north and sub-saharan africa. | 2017 | 28153710 | |
| hepatitis b virus modulates store-operated calcium entry to enhance viral replication in primary hepatocytes. | many viruses modulate calcium (ca2+) signaling to create a cellular environment that is more permissive to viral replication, but for most viruses that regulate ca2+ signaling, the mechanism underlying this regulation is not well understood. the hepatitis b virus (hbv) hbx protein modulates cytosolic ca2+ levels to stimulate hbv replication in some liver cell lines. a chronic hbv infection is associated with life-threatening liver diseases, including hepatocellular carcinoma (hcc), and hbx modul ... | 2017 | 28151934 |
| sonography predicts liver steatosis in patients with chronic hepatitis b. | liver inflammation and fibrosis may impair the ability of sonography to identify steatosis. we determined the accuracy of sonography in grading steatosis in patients with chronic hepatitis b compared to liver biopsy. | 2017 | 28151547 |
| role of tlr9 in oncogenic virus-produced cancer. | nucleic acid recognition by toll-like receptor 9 (tlr9) initiates signaling pathways that regulate the production of proinflammatory cytokines or type i interferons, as well as many other molecules required to initialize the immune response. the use of synthetic oligodeoxynucleotides (odns) has been crucial to emulate the recognition of dna sequences by tlr9. furthermore, odn administration to mice has shown to confer protection against a wide range of viral, bacterial, and parasitic pathogens. ... | 2017 | 28151089 |
| hepatitis b virus-encoded mirna controls viral replication. | micrornas (mirnas) are a class of small single-stranded non-coding functional rnas. hepatitis b virus (hbv) is an enveloped dna virus with virions and subviral forms of particles that lack a core. it was not known whether hbv encodes mirnas. here, we identified an hbv-encoded mirna (called hbv-mir-3) by deep sequencing and northern blot. hbv-mir-3 is located at nts 373-393 of the hbv genome and was generated from 3.5kb, 2,4kb and 2.1kb hbv in classic mirna biogenesis (drosha-dicer dependent) man ... | 2017 | 28148795 |
| poor sensitivity of rapid tests for the detection of antibodies to the hepatitis b virus: implications for field studies. | rapid tests (rts) can be used as an alternative method for the conventional diagnosis of hepatitis b virus (hbv). this study aims to evaluate antibodies to hbsag (anti-hbs) and antibodies to hbeag (anti-hbe) rts under different brazilian settings. the following three groups were included: gi: viral hepatitis outpatient services; gii: low resource areas; and giii: crack users and beauticians. imuno-rápido anti-hbsag™ and imuno-rápido anti-hbeag™ rts were evaluated and showed specificities greater ... | 2017 | 28146158 |
| clinical validity of metroticket calculator in transplant patients undergoing prior chemoembolization for hepatocellular carcinoma. | to test the predictive performance of the metroticket calculator for survival after liver transplantation (lt) of patients with hepatocellular carcinoma (hcc) undergoing prior transarterial chemoembolization (tace). | 2017 | 28144812 |
| proteomics approaches for early detection and targeted therapy of hepatocellular carcinoma. | hepatocellular carcinoma (hcc) is one of the leading causes of cancer related mortality worldwide. hcc incidences have increased worldwide though more prevalent in asia and africa. hepatitis b virus and hepatitis c virus infections are mostly responsible of increased number of hcc cases. biomarkers can help early detection and improve treatment regimen in patients as advanced stage is chemo-refractive with limited treatment options. potential of proteomics in finding new biomarkers for early det ... | 2017 | 28144394 |
| usefulness of humanized cdna-upa/scid mice for the study of hepatitis b virus and hepatitis c virus virology. | urokinase-type plasminogen activator-severe combined immunodeficiency (upa/scid) mice transplanted with human hepatocytes are permissive for hepatitis b virus (hbv) and hepatitis c virus (hcv) infection. however, one of the problems affecting upa transgenic mice is the expansion of mouse hepatocyte colonies due to homologous recombination of the upa gene. in this study, we attempted to infect hbv and hcv in humanized cdna-upa/scid mice, a novel upa transgenic mouse model designed to overcome thi ... | 2017 | 28141486 |
| antiviral therapies for managing viral hepatitis in lymphoma patients. | in patients with lymphoma the detection of positive hepatitis b or c viruses (hbv and hcv) serology involves crucial therapeutic consequences. in hbv-infected patients the serological profile of active (hbsag-positive) or resolved (hbsag-negative/anti-hbcab-positive) infection is associated to differential risk of viral reactivation during rituximab-based therapy and require appropriate strategies of monitoring and of antiviral prophylaxis. in hcv-associated nhl patients consolidated data demons ... | 2017 | 28140702 |
| c-terminal truncated hepatitis b virus x protein regulates tumorigenicity, self-renewal and drug resistance via stat3/nanog signaling pathway. | hepatitis b virus (hbv) is a major risk factor of chronic liver disease and hepatocellular carcinoma (hcc). random integration of hbv dna into the host genome is frequent in hcc leading to truncation of the hbv dna, particularly at the c-terminal end of the hbv x protein (hbx). c-terminally truncated hbx (hbx-δc) has been implicated in playing a pro-oncogenic role in hepatocarcinogenesis. however, the mechanism whereby hbx-δc1 contributes to hepatocarcinogenesis remains unclear. in this study, w ... | 2017 | 28186991 |
| hepatitis b virus x protein-mediated non-coding rna aberrations in the development of human hepatocellular carcinoma. | hepatitis b virus (hbv) has an important role in the development of human hepatocellular carcinoma (hcc). accumulated evidence has shown that hbv-encoded x protein (hbx) can induce both genetic alterations in tumor suppressor genes and oncogenes, as well as epigenetic aberrations in hcc pathogens. non-coding rnas (ncrnas) mainly include micrornas and long non-coding rnas (lncrnas). although ncrnas cannot code proteins, growing evidence has shown that they have various important biological functi ... | 2017 | 28186085 |
| management of antiviral resistance in chronic hepatitis b. | the primary goal of therapy for chronic hepatitis b (chb) is to prevent liver disease progression. hepatitis b surface antigen (hbsag) seroclearance or seroconversion is regarded as an optimal endpoint to discontinue treatment. however, hbsag seroclearance occurs very rarely with nucleos(t)ide analog (nuc) treatment, and long-term, almost indefinite, nuc treatment is required for the majority of patients. in patients with drug-resistant hepatitis b virus (hbv), a combination of tenofovir disopro ... | 2017 | 28183162 |
| rapid deterioration of latent hbv hepatitis during cushing disease and posttraumatic stress disorder after earthquake. | reactivation of the hepatitis b virus (hbv) is a risk in the 350 million hbv carriers worldwide. hbv reactivation may cause hepatocellular carcinoma, cirrhosis, and fulminant hepatitis, and hbv reactivation accompanied with malignant tumor and/or chemotherapy is a critical problem for patients with chronic hbv infection. multiple risk factors causing an immunosuppressive state can also induce hbv reactivation.we present a case of hbv reactivation during an immunosuppressive state caused by cushi ... | 2017 | 28183144 |
| ultrasensitive detection of serum hepatitis b virus by coupling ultrafiltration dna extraction with real-time pcr. | a simple and reliable dna extraction of hepatitis b virus (hbv) is critical in developing an ultrasensitive detection method for hbv infection. current commercially available serum hepatitis b virus (hbv) dna extraction methods are time-consuming, expensive and/or require specialized equipment, which hinders wide adoption of clinical laboratories. this study offers a report on an ultrasensitive hbv dna detection method by coupling serum hbv dna extraction by ultrafiltration (uf) with real-time p ... | 2017 | 28182626 |
| chronologic changes in serum hepatitis b virus dna, genotypes, surface antigen mutants and reverse transcriptase mutants during 25-year nationwide immunization in taiwan. | we investigated breakthrough infection and hepatitis b virus (hbv) genetic changes in immunized subjects after 25 years of a universal infant immunization. specifically, serum hbv dna, genotypes, surface antigen mutants and nucleoside analog-resistant (nar) mutants were assessed in 2853 subjects (<25 years old) surveyed in 2009, and these data were compared with the data from previous serosurveys. a comparison across different age-stratified groups using the 2009 data revealed a significant incr ... | 2017 | 28182307 |
| hepatitis b virus covalently closed circular dna homeostasis is independent of the lymphotoxin pathway during chronic hbv infection. | current treatment options for patients with chronic hepatitis b virus (hbv) infection are not curative as they are not effective in eliminating covalently closed circular dna (cccdna). cccdna is a stable template for hbv transcription in the nucleus of hepatocytes and is thought to be one of the main factors responsible for hbv persistence. recently, activation of the lymphotoxin beta receptor (ltβr) has been shown to trigger degradation of cccdna through induction of cytidine deaminases of the ... | 2017 | 28182305 |
| high expression of akr1b10 predicts low risk of early tumor recurrence in patients with hepatitis b virus-related hepatocellular carcinoma. | to clarify the relationship between aldo-keto reductase family 1 member b10 (akr1b10) expression and early hepatocellular carcinoma (hcc) recurrence, this study detected akr1b10 expression in tumor and adjacent non-tumor tissues from 110 patients with hepatitis b virus (hbv)-related hcc underwent liver resection and analyzed its correlations with clinicopathological characteristics and prognosis of these patients. detected by quantitative reverse transcription polymerase chain reaction, akr1b10 ... | 2017 | 28181486 |
| hepatitis b virus infection in undocumented immigrants and refugees in southern italy: demographic, virological, and clinical features. | the data on hepatitis b virus (hbv) infection in immigrants population are scanty. the porpoise of this study was to define the demographic, virological, and clinical characteristics of subjects infected with hbv chronic infection in a cohort of immigrants living in naples, italy. | 2017 | 28179020 |
| hepatitis b virus surface proteins accelerate cholestatic injury and tumor progression in abcb4-knockout mice. | understanding of the pathophysiology of cholestasis associated carcinogenesis could challenge the development of new personalized therapeutic approaches and thus improve prognosis. simultaneous damage might aggravate hepatic injury, induce chronic liver disease and even promote carcinogenesis. we aimed to study the effect of hepatitis b virus surface protein (hbsag) on cholestatic liver disease and associated carcinogenesis in a mouse model combining both impairments. hybrids of abcb4-/- and hbs ... | 2017 | 28178654 |
| different courses of hepatitis b reinfection after renal transplant: a case report. | hepatitis b surface antigen-positive allografts may be a source of transmission in patients who undergo renal transplantation. treatment of hepatitis b virus infection with nucleoside/nucleotide analogs in kidney recipients who have hepatitis b virus infection or who have received transplants from hepatitis b surface antigen-positive donors improves long-term patient survival. antiviral agents are administered as a preemptive or prophylactic therapy at the time of kidney transplantation, rather ... | 2017 | 28176616 |
| autologous neohep derived from chronic hepatitis b virus patients' blood monocytes by upregulation of c-met signaling. | in view of the escalating need for autologous cell-based therapy for treatment of liver diseases, a novel candidate has been explored in the present study. the monocytes isolated from hepatitis b surface antigen (hbsag) nucleic acid test (nat)-positive (hnp) blood were differentiated to hepatocyte-like cells (neohep) in vitro by a two-step culture procedure. the excess neutrophils present in hnp blood were removed before setting up the culture. in the first step of culture, apoptotic cells were ... | 2017 | 28170202 |
| health-related quality of life in pediatric patients with chronic hepatitis b living in the united states and canada. | to determine if selected socio-demographic and hbv-specific clinical factors are associated with health-related quality of life (hrqol) among pediatric patients chronically infected with hepatitis b virus (hbv). | 2017 | 28169971 |
| th17/treg imbalance is an indicator of liver cirrhosis process and a risk factor for hcc occurrence in hbv patients. | to determine the impact of t helper 17 cell (th17)/regulatory t cell (treg) ratio imbalance on the process and prognosis of hepatitis b virus (hbv)-related liver cirrhosis. | 2017 | 28169127 |
| community seroprevalence of hepatitis b, c and human immunodeficiency virus in adult population in gojjam zones, northwest ethiopia. | in ethiopia, there is lack of data on the prevalence of hepatitis b virus (hbv), hepatitis c virus (hcv) and human immune deficiency virus (hiv) infections in adult population at community level. this study aimed at determining the hbv, hcv and hiv seroprevalence in adult population at community level in east and west gojjam zones in amhara region, ethiopia. | 2017 | 28166829 |
| targeting mitochondrial dysfunction can restore antiviral activity of exhausted hbv-specific cd8 t cells in chronic hepatitis b. | hepatitis b virus (hbv)-specific cd8 t cells are functionally exhausted in chronic hepatitis b infection, and this condition can be corrected only partially through the modulation of inhibitory pathways, which suggests that a more complex molecular interplay underlies t cell exhaustion. to gain broader insight into this process and identify additional targets for the restoration of t cell function, we compared the transcriptome profiles of hbv-specific cd8 t cells from patients with acute and ch ... | 2017 | 28165481 |
| virological and serological features of acute hepatitis b in adults. | various viral kinetics among patients with acute hepatitis b (ahb) have been observed in clinical practice. this study investigated the virological, biochemical, and serological characteristics of ahb in adults.a total of 192 adult patients with ahb were recruited between december 2010 and january 2014. the quantification of biochemical and serologic markers for hepatitis b virus (hbv) infection was monitored from the onset.of the 192 patients, 113 patients were followed up. one patient died due ... | 2017 | 28207518 |
| is serum angiotensin-converting enzyme level useful for determining necroinflammatory activity in chronic hepatitis b infection? | the purpose of this study was to investigate the relationship between the findings from liver biopsy and the serum angiotensin-converting enzyme (ace) level to determine whether ace might serve as a potential noninvasive sign of necroinflammatory activity in patients with chronic hepatitis b (chb) infection. | 2017 | 28207324 |
| hepatitis b reactivation in patients with chronic hepatitis c undergoing anti-viral therapy with an interferon-free regimen. | a few cases of hepatitis b virus (hbv) reactivation during anti-viral therapy against hepatitis c (hcv) have been reported. however, the information regarding the real impact of this phenomenon is scarce. | 2017 | 28206681 |
| heteroaryldihydropyrimidine (hap) and sulfamoylbenzamide (sba) inhibit hepatitis b virus replication by different molecular mechanisms. | heteroaryldihydropyrimidine (hap) and sulfamoylbenzamide (sba) are promising non-nucleos(t)ide hbv replication inhibitors. haps are known to promote core protein mis-assembly, but the molecular mechanism of abnormal assembly is still elusive. likewise, the assembly status of core protein induced by sba remains unknown. here we show that sba, unlike hap, does not promote core protein mis-assembly. interestingly, two reference compounds hap_r01 and sba_r01 bind to the same pocket at the dimer-dime ... | 2017 | 28205569 |
| a noninvasive diagnostic model to assess nonalcoholic hepatic steatosis in patients with chronic hepatitis b. | the objective of this study was to develop a noninvasive diagnostic test for nonalcoholic hepatic steatosis in patients with chronic hepatitis b (chb) by using routinely available clinical markers. | 2017 | 28203279 |
| the new aptima hbv quant real-time tma assay accurately quantifies hepatitis b virus dna from genotypes a to f. | sensitive and accurate hepatitis b virus (hbv) dna detection and quantification are essential to diagnose hbv infection, establish the prognosis of hbv-related liver disease, and guide the decision to treat and monitor the virological response to antiviral treatment and the emergence of resistance. currently available hbv dna platforms and assays are generally designed for batching multiple specimens within an individual run and require at least one full day of work to complete the analyses. the ... | 2017 | 28202793 |
| hiv and sti s among men who have sex with men in dodoma municipality, tanzania: a cross-sectional study. | to determine the seroprevalence of hiv, sti and related risks among men who have sex with men (msm) in dodoma municipality, tanzania. | 2017 | 28202736 |
| a retrospective study of hepatitis b mother-to-child transmission prevention and postvaccination serological test results of infants at risk of perinatal transmission in two counties of middle china. | approximately, 240 million people have chronic hepatitis b worldwide, with mother-to-child-transmission (mtct) accounting for most cases. therefore, henan province, china launched a public health programme to prevent mtct. to determine the efficacy of this health programme, a survey was carried out in huixian and xinan counties, which are located in northern and western henan. all infants born in these two counties between january 1, 2013 and march 31, 2014 to a mother positive for hepatitis b s ... | 2017 | 28199772 |
| prevalence of hbsag/hbeag amongst 1 936 801 couples preparing for pregnancy in rural china: an observational study. | there are few extant studies on the prevalence of hbv infection in couples preparing for pregnancy. we assessed the prevalence of hepatitis b surface antigen (hbsag) and hepatitis b e antigen (hbeag) in couples preparing for pregnancy in rural china, and the association between hbv prevalence and the statuses of hbsag/hbeag and alt in the spouses. we performed a nationwide cross-sectional study, using data from a health check-up program for 1 936 801 rural couples from 31 provinces preparing for ... | 2017 | 28199770 |
| predicting short-term survival after liver transplantation on eight score systems: a national report from china liver transplant registry. | to compare the performance of eight score systems (meld, umeld, meld-na. imeld, ukeld, meld-as, ctp, and mctp) in predicting the post-transplant mortality, we analyzed the data of 6,014 adult cirrhotic patients who underwent liver transplantation between january 2003 and december 2010 from the china liver transplant registry database. in hepatitis b virus (hbv) group, meld, umeld and meld-as showed good predictive accuracies at 3-month mortality after liver transplantation; by comparison with ot ... | 2017 | 28198820 |
| a molecular epidemiology study investigating familial clustering of hepatitis b virus infection in families with unfavorable prognoses in northwest china. | hepatitis b virus (hbv) infections and adverse outcome have been demonstrated to show characteristics of familial clustering. the aim of this study was to investigate the prevalence of different hbv genotypes, hbv sub-genotypes, and pre-s mutations associated with familial hbv infection clusters with unfavorable prognoses. families presenting with clustered hbv infections and unfavorable prognoses were enrolled in this study. non-clustered hbv-infected individuals were used as the control group. ... | 2017 | 28198546 |
| serum lipid alterations identified in chronic hepatitis b, hepatitis b virus-associated cirrhosis and carcinoma patients. | the incidences of chronic hepatitis b (chb), hepatitis b virus (hbv)-associated cirrhosis and hbv-associated carcinoma are high and increasing. this study was designed to evaluate serum lipid metabolite changes that are associated with the progression from chb to hbv-associated cirrhosis and ultimately to hbv-associated hcc. a targeted metabolomic assay was performed in fasting sera from 136 chb patients, 104 hbv-associated cirrhosis, and 95 hbv-associated hcc using ultra-performance liquid chro ... | 2017 | 28198443 |
| mutation in the s gene of hepatitis b virus and anti-hbs subtype-nonspecificity contributed to the co-existence of hbsag and anti-hbs in patients with chronic hepatitis b virus infection. | the mechanism for the co-existence of hepatitis b surface antigen (hbsag) and antibodies to hbsag (anti-hbs) in chronic hbv infected patients remains controversial. this study aimed to explore the role of hbv s gene mutation and anti-hbs subtype-nonspecificity in patients with simultaneous hbsag/anti-hbs positivity. chronic hbv infections with (n = 145, group i) and without (n = 141, group ii) anti-hbs were included. the s gene was amplified and sequenced. the neutralization experiment was used ... | 2017 | 28198078 |
| economic analysis and budget impact of tenofovir and entecavir in the first-line treatment of hepatitis b virus in italy. | chronic hepatitis b is a common, progressive disease, particularly when viral replication is detected. oral antivirals can suppress viral replication and prevent or delay the development of cirrhosis and liver-related complications. the treatments of chronic hepatitis b cannot totally cure the disease but can prevent its progression to hepatocellular carcinoma, decreasing the levels of both morbidity and mortality. to date, there are several therapies indicated by the international guidelines as ... | 2017 | 28197805 |
| effects of vaccine-acquired polyclonal anti-hbs antibodies on the prevention of hbv infection of non-vaccine genotypes. | in universal hepatitis b (hb) vaccination, single vaccine-derived polyclonal anti-hbs antibodies (anti-hbs) need to inhibit infection of hb viruses (hbv) of non-vaccine genotypes. we experimentally addressed this issue. | 2017 | 28197802 |
| high nkg2a expression contributes to nk cell exhaustion and predicts a poor prognosis of patients with liver cancer. | background and aims: as the predominant lymphocyte subset in the liver, natural killer (nk) cells have been shown to be highly associated with the outcomes of patients with chronic hepatitis b virus infection (chb) and hepatocellular carcinoma (hcc). previously, we reported that nkg2a, a checkpoint candidate, mediates human and murine nk cell dysfunction in chb. however, nk cell exhaustion and, particularly, the level of nkg2a expression within liver tumors have not been reported. methods: in th ... | 2017 | 28197391 |
| knowledge, current status, and barriers toward healthcare worker vaccination among family medicine resident participants in a web-based survey in korea. | we investigated the knowledge, status, and barriers toward healthcare workers receiving vaccinations among korean family medicine residents. to date, a systematic study has not been conducted among medical practitioners examining these variables. | 2017 | 28197329 |
| development and validation of a prognostic model for acute-on-chronic hepatitis b liver failure. | the canonic study proposed the chronic liver failure consortium acute-on-chronic liver failure (clif-c aclf) prognostic model at the european association for the study of the liver-clif diagnosis. this study aimed to develop and validate a prognostic model for predicting the short-term mortality of hepatitis b virus (hbv) aclf as defined by the asia-pacific association for the study of the liver. | 2017 | 28195876 |
| elevated pre-treatment il-18 level is associated with hbeag seroconversion in hiv-hbv coinfection. | in hepatitis b virus (hbv) infected patients, hepatitis b e antigen (hbeag) seroconversion is associated with better outcomes. interleukin-18 (il-18) controls hepatitis b replication in a mouse model. however, its role in treatment response in hiv/hbv co-infected patients is unknown. | 2017 | 28195558 |
| sodium taurocholate cotransporting polypeptide is the limiting host factor of hepatitis b virus infection in macaque and pig hepatocytes. | infections with the human hepatitis b (hbv) and hepatitis d virus (hdv) depend on species-specific host factors like the receptor human sodium taurocholate cotransporting polypeptide hntcp. complementation of mouse hepatocytes with hntcp confers susceptibility to hdv but not hbv indicating the requirement of additional hbv-specific factors. as an essential premise towards the establishment for an hbv-susceptible animal model, we investigated the role of hntcp as a limiting factor of hepatocytes ... | 2017 | 28195359 |
| pre-s2 mutant-induced mammalian target of rapamycin signal pathways as potential therapeutic targets for hepatitis b virus-associated hepatocellular carcinoma. | chronic hepatitis b virus (hbv) infection is a major risk factor for hepatocellular carcinoma (hcc). pre-s2 mutant represents an hbv oncoprotein that is accumulated in the endoplasmic reticulum (er) and manifests as type ii ground glass hepatocytes (gghs). pre-s2 mutant can induce er stress and initiate multiple er stress-dependent or -independent cellular signal pathways, leading to growth advantage of type ii ggh. importantly, the mammalian target of rapamycin (mtor) signal pathways are consis ... | 2017 | 28195035 |
| type i ifn augments il-27-dependent trim25 expression to inhibit hbv replication. | hepatitis b virus (hbv) can cause chronic hepatitis b, which may lead to cirrhosis and liver cancer. type i interferon (ifn) is an approved drug for the treatment of chronic hepatitis b. however, the fundamental mechanisms of antiviral action by type i ifn and the downstream signaling pathway are unclear. trim25 is an ifn-stimulated gene (isg) that has an important role in rig-i ubiquitination and activation. whether trim25 is induced in liver cells by type i ifn to mediate anti-hbv function rem ... | 2017 | 28194021 |
| anti-hbv drugs suppress the growth of hbv-related hepatoma cells via down-regulation of hepatitis b virus x protein. | chronic infection of hepatitis b virus (hbv) is closely associated with the development of hepatocellular carcinoma (hcc). meta-analyses show that adjuvant anti-hbv therapy is effective for hbv-related hcc patients in clinical. however, the significance that anti-hbv drugs depress hcc is poorly understood. here, we investigated the effects of telbivudine (ldt), entecavir (etv) and interferon-α2b (ifn-α2b) on hbv-related hcc. our data showed that the treatment with the drugs significantly suppres ... | 2017 | 28192212 |
| detection of antibodies against hepatitis b virus surface antigen and hepatitis c virus core antigen in plasma with a waveguide-mode sensor. | in large-scale disasters, such as huge significant earthquakes, on-site examination for blood typing and infectious disease screening will be very helpful to save lives of victims who need surgical treatment and/or blood transfusion. however, physical damage, such as building collapse, electric power failure and traffic blockage, disrupts the capacity of the medical system. portable diagnostic devices are useful in such cases of emergency. in this study, we evaluated a waveguide-mode sensor for ... | 2017 | 28190739 |
| tenofovir has inferior efficacy in adefovir-experienced chronic hepatitis b patients compared to nucleos(t)ide-naïve patients. | a recent study reported that entecavir had inferior efficacy in nucleos(t)ide analogue (na)-experienced chronic hepatitis b (chb) patients compared to na-naïve patients. we sought to compare the efficacy of tenofovir disoproxil fumarate (tdf) in na-experienced and na-naïve chb patients. | 2017 | 28190329 |
| development of a hepatitis b virus reporter system to monitor the early stages of the replication cycle. | currently, it is possible to construct recombinant forms of various viruses, such as human immunodeficiency virus 1 (hiv-1) and hepatitis c virus (hcv), that carry foreign genes such as a reporter or marker protein in their genomes. these recombinant viruses usually faithfully mimic the life cycle of the original virus in infected cells and exhibit the same host range dependence. the development of a recombinant virus enables the efficient screening of inhibitors and the identification of specif ... | 2017 | 28190076 |
| performance of hbsag quantification assays for detection of hepatitis b virus genotypes and diagnostic escape-variants in clinical samples. | the impact of hepatitis b virus (hbv) genomic variability on the measurement of hbsag level has been poorly evaluated. | 2017 | 28189936 |
| comparison of the efficacy and safety of entecavir and tenofovir in nucleos(t)ide analogue-naive chronic hepatitis b patients with high viraemia: a retrospective cohort study. | the aims of this study are to compare the long-term efficacy and safety of entecavir and tenofovir in nucleos(t)ide analogue (na)-naive patients with chronic hepatitis b (chb) with high hepatitis b virus (hbv) dna (> 6 log10 iu/ml). | 2017 | 28189857 |
| the role of st2 and st2 genetic variants in schistosomiasis. | chronic schistosomiasis and its severe complication, periportal fibrosis, are characterized by a predominant th2 response. to date, specific single nucleotide polymorphisms in st2 have been some of the most consistently associated genetic variants for asthma. | 2017 | 28189770 |
| hepatitis b immunoglobulin during pregnancy for prevention of mother-to-child transmission of hepatitis b virus. | hepatitis is a viral infection of the liver. it is mainly transmitted between people through contact with infected blood, frequently from mother to baby in-utero. hepatitis b poses significant risk to the fetus and up to 85% of infants infected by their mothers at birth develop chronic hepatitis b virus (hbv) infection. hepatitis b immunoglobulin (hbig) is a purified solution of human immunoglobulin that could be administered to the mother, newborn, or both. hbig offers protection against hbv in ... | 2017 | 28188612 |
| prmt5 restricts hepatitis b virus replication via epigenetic repression of cccdna transcription and interference with pgrna encapsidation. | chronic hepatitis b virus (hbv) infection remains a major health problem worldwide. the covalently closed circular dna (cccdna) minichromosome, which serves as the template for the transcription of viral rnas, plays a key role in viral persistence. while accumulating evidence suggests that cccdna transcription is regulated by epigenetic machinery, particularly the acetylation of cccdna-bound histone 3 (h3) and h4, the potential contributions of histone methylation and related host factors remain ... | 2017 | 28236308 |
| characterization of hepatitis b virus (hbv) pres/s gene mutations in blood donors with occult hbv infection in the baoji area of north china. | occult hepatitis b virus (hbv) infection (obi) in blood donors was investigated in the baoji area of north china, and obi-related viral mutations in donors were characterized. | 2017 | 28236303 |
| widespread geographical disparities in chronic hepatitis b virus infection in algeria. | algeria is the largest country of africa, with a population of 40 million inhabitants living in disparate environments from the sahara to the large cities of the mediterranean coast. the molecular epidemiology of hepatitis b virus (hbv) variants has been partially described, but variations in the seroprevalence of hbv surface antigen (hbsag) throughout the algerian territories are still poorly described. we analyzed demographic features of new cases of chronic infection collected in 41 administr ... | 2017 | 28236070 |
| [spontaneous remission of hcv infection after autologous stem cell transplantation in a 58-year-old man]. | we report about a 58-year-old man with a chronic and treatment-naive hepatitis c virus (hcv) infection of genotype 1b, who had undergone autologous stem cell transplantation twice due to multiple myeloma. subsequently, a high-level viremic reactivation of an occult hepatitis b virus (hbv) infection and also a reverse seroconversion was observed. furthermore, a sustained spontaneous remission of hcv infection was seen. antiviral therapy of hbv infection was initiated with tenofovir. seven months ... | 2017 | 28235985 |
| hepatic deficiency of the pioneer transcription factor foxa restricts hepatitis b virus biosynthesis by the developmental regulation of viral dna methylation. | the foxa family of pioneer transcription factors regulates hepatitis b virus (hbv) transcription, and hence viral replication. hepatocyte-specific foxa-deficiency in the hbv transgenic mouse model of chronic infection prevents the transcription of the viral dna genome as a result of the failure of the developmentally controlled conversion of 5-methylcytosine residues to cytosine during postnatal hepatic maturation. these observations suggest that pioneer transcription factors such as foxa, which ... | 2017 | 28235042 |
| lamivudine, entecavir, or tenofovir treatment of hepatitis b infection: effects on calcium, phosphate, fgf23 and indicators of bone metabolism. | patients with chronic hepatitis b virus (hbv) are often treated with nucleoside/nucleotide antiviral agents and metabolic bone toxicity is a possible concern. | 2017 | 28233741 |
| hepatitis b and nafld: lives crossed. | hepatitis b virus infection seems to protect against steatosis and insulin resistance decreasing nafld. metabolic syndrome has been associated with increased risk of disease progression to cirrhosis and liver cancer in hepatitis b. hbsag seroclearance increased over time and it could be a confounding factor when analysing nafld and hepatitis b prevalence. | 2017 | 28233740 |
| label-free detection of hepatitis b virus using solution immersed silicon sensors. | highly sensitive solution immersed silicon (sis) biosensors were developed for detection of hepatitis b virus (hbv) infection in the early stage. the ultrasensitivity for overlayer thickness at the nonreflecting condition for the p-polarized wave is the basis of sis sensing technology. the change in thickness due to biomolecular interactions and change in refractive index of the surrounding buffer medium were assessed simultaneously using two separate ellipsometric parameters (ψ and δ), respecti ... | 2017 | 28231713 |
| association of neutrophil-lymphocyte ratio and t lymphocytes with the pathogenesis and progression of hbv-associated primary liver cancer. | the neutrophil-lymphocyte ratio (nlr) is a new prognostic predictor for patients with liver cancer. the association of nlr and t lymphocytes with the pathogenesis and progression of liver cancer is poorly understood. | 2017 | 28231294 |
| reactivation of hepatitis b in patients of chronic hepatitis c with hepatitis b virus infection treated with direct acting antivirals. | hepatitis b virus (hbv) may reactivate when treating chronic hepatitis c (chc) with direct acting antivirals (daa). we aim to investigate the risk of hbv reactivation during daa therapy. | 2017 | 28230928 |
| prec and c regions of woodchuck hepatitis virus facilitate persistent expression of surface antigen of chimeric whv-hbv virus in the hydrodynamic injection balb/c mouse model. | in the hydrodynamic injection (hi) balb/c mouse model with the overlength viral genome, we have found that woodchuck hepatitis virus (whv) could persist for a prolonged period of time (up to 45 weeks), while hepatitis b virus (hbv) was mostly cleared at week four. in this study, we constructed a series of chimeric genomes based on hbv and whv, in which the individual sequences of a 1.3-fold overlength hbv genome in pbs-hbv1.3 were replaced by their counterparts from whv. after hi with the whv-hb ... | 2017 | 28230775 |
| complete genome sequence of the who international standard for hepatitis b virus dna. | the world health organization (who) international standard (is) for hepatitis b virus (hbv) dna for use in nucleic acid amplification assays was characterized by determining the complete genome sequence, which was assigned genotype a. this information will aid the design, development, and evaluation of hbv dna amplification assays. | 2017 | 28209818 |
| atorvastatin decreases hbx-induced phospho-akt in hepatocytes via p2x receptors. | hepatocellular carcinoma (hcc) is rated as the fifth most common malignancy and third in cancer related deaths worldwide. statins, hmg-coa reductase inhibitors, are potent cholesterol lowering drugs and recent epidemiological evidence suggests that statins prevent aggressive hcc development. previous experiments revealed that statins downregulate phosphorylated akt (pakt). here, it is demonstrated that atorvastatin decreases nuclear pakt levels in pancreatic and lung cancer cell lines within min ... | 2017 | 28209758 |
| first epidemiological and phylogenetic analysis of hepatitis b virus infection in migrants from mali. | the armed conflict in mali caused a migration crisis since 2012. most malian refugees were in italy. in sub-saharan africa, the seroprevalence of anti-hbv antibodies is particularly high. genotype e is the most prevalent throughout a crescent covering area from angola to senegal, including mali. we report 16 hbv positive individual from 136 malian asylum seekers in order to investigate the genetic diversity of hbv in this population. sequencing and phylogenetic analysis has been used. the hbv ge ... | 2017 | 27576107 |
| hepatitis b virus sequencing and liver fibrosis evaluation in hiv/hbv co-infected nigerians. | molecular characteristics of hepatitis b virus (hbv), such as genotype and genomic mutations, may contribute to liver-related morbidity and mortality. the association of these characteristics with liver fibrosis severity in sub-saharan africa is uncertain. we aimed to characterize molecular hbv features in hiv/hbv co-infected nigerians and evaluate associations between these characteristics and liver fibrosis severity before and after antiretroviral therapy (art) initiation. | 2017 | 28376292 |
| permissive, in vitro replication of hepatitis b virus genotype e. | a cloned stable cell line, hepg2-hbve6, was established following transfection of hepg2 cells with a retroviral plasmid into which a 1.1-fold genomic construct of hepatitis b virus (hbv) belonging to genotype e (hbv/e) was inserted. the cell line retains the entire hbv/e insert, and produces episomal hbv dna. it expresses hbv pregenomic, pres1 and pres2/s transcripts, and sheds hepatitis b surface and e antigens as well as structures resembling hbv-subviral and dane particles. the hepg2-hbve6 ce ... | 2017 | 28122202 |
| origin and evolutionary dynamics of hepatitis b virus (hbv) genotype e in madagascar. | africa is one of the endemic regions of hbv infection. in particular, genotype e is highly endemic in most of sub-saharan africa such as west african countries where it represents more than 90% of total infections. madagascar, which is classified as a high endemic area for hbv and where the most prevalent genotype is e, might play a relevant role in the dispersion of this genotype due to its crucial position in the indian ocean. the aim of this study was to investigate the origin, population dyn ... | 2017 | 28081689 |
| nitrative and oxidative dna damage in infection-related carcinogenesis in relation to cancer stem cells. | infection and chronic inflammation have been recognized as important factors for carcinogenesis. under inflammatory conditions, reactive oxygen species (ros) and reactive nitrogen species (rns) are generated from inflammatory and epithelial cells, and result in the formation of oxidative and nitrative dna lesions, such as 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodg) and 8-nitroguanine. the dna damage can cause mutations and has been implicated in inflammation-mediated carcinogenesis. it has bee ... | 2017 | 28163802 |
| evaluation of helicobacter pylori infection in patients with chronic hepatic disease. | the 13c urea breath test (13c-ubt) is the gold standard for detecting helicobacter pylori infection. h. pylori pathogenesis in patients with hepatitis b virus (hbv) and related diseases remains obscure. we used 13c-ubt to detect h. pylori infection in patients with chronic hbv infection, hbv-related cirrhosis, hbv-related hepatic carcinoma, and other chronic hepatic diseases. | 2017 | 28091405 |
| high association of t1858-g1896 precore mutations with impaired base pairing and high hepatitis b virus dna levels in hbeag-negative chronically infected patients. | the progression of liver disease in hepatitis b virus (hbv) infection is fostered by active virus replication. mutations in the basal core promoter (bcp) and precore (pc) regions of the hbv genome are known to have an impact on viral replication. the aim of the present study was to assess the correlation of mutation profiles in the bcp and pc regions with the viral load in hbeag-negative chronically infected patients. the hbv genotype, bcp/pc mutations, serum hbv dna levels, and associated serol ... | 2017 | 28289975 |
| detection of hbv dna and antigens in hbsag-positive patients with primary hepatocellular carcinoma. | hepatitis b virus (hbv) markers include hbv deoxyribonucleic acid (dna) and hbv antigens. the former involves hbv covalently closed circular dna (cccdna) as well as total hbv dna, whereas the latter involves hbsag, hbcag, and hbx. | 2017 | 28286056 |
| hepatitis b vaccination status in an at-risk adult population: long-term immunity but insufficient coverage. | in france, hepatitis b (hb) vaccine has been offered to all infants since 1994, and was proposed to all children aged 11 years from 1994 to 1998. nevertheless, hb vaccine hesitancy may result in low vaccination coverage in present-day at-risk adults. we aimed to determine hb vaccination coverage in adults attending a free testing center for sexually transmitted infections (sti). as part of routine care, three classes of data were anonymously collected from attendees over a 3-month period: result ... | 2017 | 28285330 |
| no. 342-hepatitis b and pregnancy. | to review the epidemiology, natural history, evaluation, and treatment of hepatitis b virus (hbv) infection during pregnancy. this will aid obstetric care providers in counseling their patients regarding perinatal risks and management options available to pregnant women with hepatitis b. | 2017 | 28284515 |
| a highly sensitive electrochemical immunosensor for hepatitis b virus surface antigen detection based on hemin/g-quadruplex horseradish peroxidase-mimicking dnazyme-signal amplification. | here we prepared an electrochemical immunosensor employing au sheet as working electrode, fe3o4 magnetic nanoparticles (mnps) as supporting matrix and hemin/g-quadruplex dnazyme as signal amplifier for determination of hepatitis b virus surface antigen (hbsag). first, the primary antibody of hbs (ab1) was immobilized on the surface of the carboxyl-modified mnps. then, the assembly of antibody and alkylthiol/g-quadruplex dna/hemin on gold nanoparticles was used as bio-bar-coded nanoparticle probe ... | 2017 | 28284078 |