Publications

[antibiotic therapy of infections caused by proteus and pseudomonas pyocyanea].		1972	4666690
[bacterial vaccines for oral administration and local mechanisms of immunity].		1972	4669411
the behaviour in man of c. p. 15,464, a carbenicillin absorbed following oral administration.		1972	4669556
in vitro studies of tobramycin, an aminoglycoside antibiotic.	tobramycin is an aminoglycoside antibiotic which has excellent antibacterial activity against pseudomonas, staphylococcus aureus, and many members of the enterobacteriaceae. most strains of serratia, providence, streptococcus, and diplococcus pneumoniae were resistant to concentrations of tobramycin which could be achieved in man. tobramycin was effective against certain pseudomonas strains resistant to gentamicin. the growth medium used to determine the inhibitory level of tobramycin had a sign ...	1972	4670427
structure-activity relationships among a group of 7-(alpha-(n,n'-substituted-amidinothio)-acetamido) cephalosphoranic acids.	structure-activity relationships were examined for a number of 7-[alpha-(n,n'-substituted-amidinothio)-acetamido] cephalosporanic acids, including several wherein the amidino group was cyclized into six, seven, and eight-membered rings and a series wherein alkyl, cycloalkyl, alkenyl, and alkynyl radicals were substituted on the nitrogens of the noncyclized amidino group. derivatives containing an unsubstituted cyclized amidino group had comparable antibacterial activity in vitro and in general h ...	1972	4670429
7-(alpha-(1-methyl-4-pyridinothio)-acetamido) cephalosporanic acid.	7-[alpha-(1-methyl-4-pyridiniothio)-acetamido] cephalosporanic acid, referred to herein as bl-s 217, is a new broad-spectrum semisynthetic cephalosporin that offers several advantages over cephalothin. a comparison of the activity in vitro of these antibiotics indicates that bl-s 217 is about eightfold more effective against streptococcus pyogenes and diplococcus pneumoniae. against gram-negative bacteria, bl-s 217 possesses a broader antibacterial spectrum than cephalothin, particularly against ...	1972	4670430
in vitro evaluation of tobramycin, a new aminoglycoside antibiotic.	one hundred fifty-two strains of escherichia coli, klebsiella-enterobacter, pseudomonas aeruginosa, proteus species, and staphylococcus aureus were inhibited by 3.1 mug of tobramycin/ml in a broth-dilution method and showed zones of inhibition of 16 mm or more around a 10-mug tobramycin disc in the kirby-bauer method. tobramycin was most active against s. aureus, 100% of strains being inhibited by 0.1 mug/ml. all strains of e. coli, k. pneumoniae, p. aeruginosa, and indole-positive proteus speci ...	1972	4670478
in vitro susceptibility testing with tobramycin.	tobramycin (nebramycin factor 6) is an aminoglycoside antibiotic active in vitro against many gram-negative species and staphylococcus aureus. the susceptibility of 191 recently isolated pathogenic bacteria to tobramycin was measured by both a routine broth dilution procedure and the fda standardized disc technique using a 10-mug disc. twenty-five isolates each of escherichia, enterobacter, klebsiella, indole-negative proteus, pseudomonas, serratia, and s. aureus, and 16 isolates of group d ente ...	1972	4670483
butirosin, a new aminoglycosidic antibiotic complex: antibacterial activity in vitro and in mice.	butirosin is a new aminoglycosidic antibiotic complex which has broad gram-negative and gram-positive inhibitory antibacterial activity, as well as some bactericidal properties. significantly susceptible bacteria include strains of staphylococcus aureus and streptococcus pyogenes, and pathogenic gram-negative species such as enterobacter aerogenes, escherichia coli, klebsiella pneumoniae, proteus mirabilis and p. vulgaris, salmonella enteritidis and s. typhimurium, shigella flexneri and s. sonne ...	1972	4670492
activity of methacycline, related tetracyclines, and other antibiotics against various l-forms and their parent bacteria in vitro.	the activity of methacycline against microbial l-forms and their parent bacteria was compared with that of oxytetracycline, chlortetracycline, tetracycline, and demethylchlortetracycline, as well as with that of 22 other antibiotics which included examples of major groups of antibiotics. the l-forms and bacteria used were streptococcus faecalis, s. faecium, s. faecalis var. zymogenes, staphylococcus aureus (three strains), proteus mirabilis (two strains), pseudomonas aeruginosa, escherichia coli ...	1972	4670500
cephamycins, a new family of beta-lactam antibiotics. 3. in vitro studies.	cephamycins a, b, and c are naturally produced cephalosporin-type antibiotics. although a and b were found to be more active than c against gram-positive organisms, they were not so active against such strains as are cephalosporin c or the semisynthetic antibiotics cephaloridine and cephalothin. against gram-negative organisms, cephamycin c was more active than a or b and, in general, was as active as the cephalosporins. in addition, cephamycin c was active in vitro against clinically isolated s ...	1972	4670501
cephamycins, a new family of beta-lactam antibiotics. iv. in vivo studies.	cephamycin a was found to be more active in vivo than cephamycin b. in comparison with cephamycin c, cephamycin a was more active against gram-positive organisms but less active against gram-negative organisms. given subcutaneously, cephamycin c had good in vivo gram-negative activity, comparing favorably with cephalothin and cephaloridine against cephalosporin-susceptible organisms. in general, against the gram-negative organisms, it was more active than cephalothin or cephalosporin c and about ...	1972	4670502
tobramycin: in vitro activity and comparison with kanamycin and gentamicin.	the in vitro activity of the aminoglycoside antibiotic tobramycin was demonstrated by broth dilution and single-disc methods on 50 isolates each of staphylococcus aureus, klebsiella or enterobacter, indole-positive and -negative proteus, escherichia coli, and pseudomonas aeruginosa. all organisms were inhibited by 6.25 mug or less of the drug/ml. pseudomonas strains resistant to kanamycin or gentamicin or both were susceptible to tobramycin. those strains which were inhibited by 6.25 mug of tobr ...	1972	4670697
[clinical experiences with urikult. a comparison of pathogen findings in conventional urine culture and slide culture].		1972	4678514
[letter: hospital infections].		1972	4680686
disinfectants and gram-negative bacteria.		1972	4109832
enzyme evolution in the enterobacteriaceae.	an immunological approach has been used for the study of alkaline phosphatase evolution in bacteria of the family enterobacteriaceae. antisera were prepared against alkaline phosphatase from escherichia coli and klebsiella aerogenes and tested against the unpurified alkaline phosphatases of 32 strains of enterobacteria by double diffusion and quantitative micro-complement fixation. the immunological relationships detected among the alkaline phosphatases of enterobacteria agree approximately with ...	1972	4113124
the immunogenicity of proteus vulgaris ox 19 in the rabbit.		1972	4114566
bacteriuria of elderly women in hospital: occurrence and drug resistance.		1972	4115344
mucopeptide hydrolases and bacterial "persisters".		1972	4115349
absence of nephrotoxicity during cephaloridine therapy for urinary-tract infection.		1972	4115572
factors influencing colonisation and antibiotic-resistance patterns of gram-negative bacteria in hospital patients.		1972	4115815
clearance from a hospital of gram-negative bacilli that transfer carbenicillin-resistance to pseudomonas aeruginosa.		1972	4116823
studies on changes in skin surface bacteria in induced miliaria and associated hypohidrosis.		1972	4117084
direct evidence for immunoglobulins on the surface of thymus lymphocytes of amphibian larvae.		1972	4117283
diagnosis of urinary-tract infection in general practice.		1972	4117810
[penicillin-induced filamentous forms in proteus vulgaris p 18 ].		1972	4118184
serum proteins of gnotobiotic rats.	cellulose-acetate and agar gel immunoelectrophoresis were used to study the serum protein patterns of germfree rats before and after monoassociation with a pure culture of staphylococcus aureus (phage type 80/81), streptococcus faecalis, lactobacillus acidophilus, bacteroides fragilis, pseudomonas aeruginosa, or proteus vulgaris. all six bacteria quickly established themselves in the gastrointestinal tract of the germfree rat, and all six increased the animals' total serum proteins. only s. aure ...	1972	4120245
ethylenediamine tetra-acetic acid (edta) induced morphological changes in proteus mirabilis.		1972	4145153
[aerobic faecal flora of reptiles with special reference to the enterobacteria of snakes].		1972	4145166
[influence of thallium acetate on the growth of acholeplasmataceae, mycoplasmataceae, and some bacteria species].		1972	4145172
[the "pril-mannite-agar" in salmonella diagnostics].		1972	4145492
[development of penicillin resistance and its prevention].		1972	4145556
[effect of levallorphen, a morphine derivative, on the transmission of drug-resistance factors].		1972	4145559
[the presence of oscillations in growing bacterial cultures].		1972	4145602
[structural changes in cell-wall murein in defective cell-shape mutants of proteus mirabilis].		1972	4145631
[electron microscopy and chemical analyses on the cell wall structure of proteus mirabilis and escherichia coli b].		1972	4145636
bacteriocinogeny in proteus-species.		1972	4144798
effect of polysorbate 80 and phenylethanol on the antibacterial activity of fentichlor.		1972	4144922
[the combination sulfamethoxazole-trimethoprim in vitro].		1972	4144946
evaluation of clinical and antibacterial activity of pyrrolidinemethyltetracycline.		1972	4147372
[formation of extracellular rnases by microorganisms on a synthetic medium].		1972	4197399
[toxic properties of the metabolites of some saprophytic bacteria].		1972	4197401
[study of the antibiotic activity of mycetes isolated from the soil of various regions of bulgaria. i].		1972	4197602
antibacterial action of complexing compounds. the influence of disodium versenate on microorganisms in vitro.		1972	4197730
[antimicrobial properties of cranberry].		1972	4198007
[studies on the isolation and elucidation of constitution of the rhyodomycin antibiotic agent in the streptomyces strain ja 8467].		1972	4198117
[carbenicillin treatment of pseudomonas aeruginosa infections and proteus infections in infants].		1972	4198126
[problems associated with the administration of combined antibacterial drugs].		1972	4200239
[antibacterial activity of lividomycin against several bacteria isolated from clinical specimens].		1972	4198941
[bacteriological studies on wall to wall carpeting. i. significance of threatened and texture of wall to wall carpeting for the disinfectant].		1972	4198443
[the isoelectric point of extracellular proteases of certain bacterial species].		1972	4200183
[antibiotic produced by the mutant variant p3 of actinomyces species no. 2 strain].		1972	4121153
production of glutamine synthetase by proteus mirabilis in short time periods.		1972	4154487
septic arthritis.		1972	5008465
urinary tract calculi and ileal conduit diversion.		1972	5013768
[indications for trimethoprim in otorhinolaryngology].		1972	5014141
[pathogenicity, biochemical properties and sensitivity to antibiotics of rettgerella strains from clinical material].		1972	5020575
[bacteriological follow-up studies in vena cava catheterization].		1972	5022355
alkenyl and alkyl phosphatides in proteus and its l forms.		1972	5025027
ion levels of amoeba proteus, amoeba discoides and their heterospecific hybrids.		1972	5025937
[proteus meningoencephalitis in a 3-week-old infant].		1972	5026345
connections between cisternae of the golgi apparatus and the granular endoplasmic reticulum in amoeba proteus.		1972	5029370
[microflora of the department of acute respiratory diseases and the spreading of proteus strains].		1972	5032303
the occurrence of empyema cystis: management of the bladder to be defunctionalized.		1972	5034022
humoral antibody production following primary and secondary immunization in rabbits treated with thiamphenicol and chloramphenicol.		1972	5034723
review of a 5-year experience with the radiostrontium bone scintiscan.	radiostrontium ((85)sr) skeletal scintiscanning was done on 640 cases and 520 were included in a review. forty-eight percent of 359 patients with biopsy-proved malignant disease had secondary skeletal involvement; in 17 percent the involvement was identified by scintiscanning alone. false-negative scintiscans were recorded in 0.9 percent. unusual (85)sr localization was found in a bone infarct, in proteus bursitis and in a pulmonary aspergillosis infiltrate. serum alkaline phosphatase levels wer ...	1972	5039800
[relationship of dwarf tapeworms and microflora in intestinal parasitocenosis of white mice. ii. changes in the intestinal microflora of white mice in the course of development of the dwarf tapeworm].		1972	5042551
[carbecillin therapy of pseudomonas aeruginosa and proteus infections in infancy].		1972	5043096
biological properties of three 3-heterocyclic-thiomethyl cephalosporin antibiotics.	three new cephalosporin antibiotics, prepared by substitution of heterocyclic groups on 7-aminocephalosporanic acid, possess certain desirable chemical or biological properties. all three compounds are active in vitro against a variety of gram-positive and gram-negative bacteria. minimal inhibitory concentrations (mic) of these bactericidal antibiotics were not significantly affected by changes in ph or nacl content of nutrient broth, or by the use of different inoculum sizes. however, agar-dilu ...	1972	5045468
the treatment of chronic renal infections with carbenicillin-gentamicin: a report of two cases.		1972	5047394
relationship of intraventricular gentamicin levels to cure of meningitis. report of a case of proteus meningitis successfully treated with intraventricular gentamicin.		1972	5049822
[respiratory manifestations in the course of the gougerot-sjogren syndrome (with report of 2 cases)].		1972	5051110
[radiobiologic reactions in amoeba proteus. i. viability, delay in cell division and forms of death following gamma-irradiation of radiosensitive and radioresistant strains].		1972	5052698
[microcirculation disorders in the buccal pouch in the syrian hamster at the later stage of endotoxic shock].		1972	5054102
effectiveness of pulsating water jet lavage in treatment of contaminated crushed wounds.		1972	5056898
the isolation and characterization of a strain of bdellovibrio bacteriovorus.		1972	5058665
integration of obstetric and gynecologic inpatients: morbidity.		1972	5059591
penicillin and related antibiotics: gram-negative infections: urine.		1972	5061042
asymptomatic candiduria. prognosis, complications and some other clinical considerations.		1972	5064886
[brain abscess in infants].		1972	5068781
[characteristics of the enzymatic properties of a collection of bacteria of providencia genus].		1972	5071622
enzymatic inactivation of gentamycin by extracts from antibiotic resistant proteus morganii strains.		1972	5073886
[the effect of polysynthetic penicillin, ampicillin and methicillin preparations on proteus].		1972	5077226
urinary tract infection and drug response.		1972	4631866
function of various intestinal bacteria in converting germfree mice to the normal state.	earlier work had shown that a collection of anaerobic bacteria, in conjunction with facultative anaerobes, may be implanted into germfree mice, thereby rendering the animals "normal" with respect to a variety of parameters tested. the present experiments indicate that a different collection of anaerobic bacteria, isolated from the cecum of normal mice, was necessary to convert germfree mice to the "normal" state when the animals were fed a crude diet, rather than the refined food which had been ...	1972	4631910
semisynthetic -lactam antibiotics. 2. synthesis and properties of d- and l- -sulfobenzylpenicillins.		1972	4631919
[synergism of trimethoprim and sulfamethoxazole action on microorganisms isolated from persons with urinary tract infections].		1972	4632270
the effect of fungal metabolites and of coriander seeds on the growth of pathogenic bacteria.		1972	4632293
[composition of the microflora from suppurative foci in inflammatory diseases of the hand and its sensitivity to antibiotics].		1972	4633058
in vitro activity of tobramycin and gentamicin.	the in vitro antimicrobial activity of tobramycin and gentamicin was compared against 362 bacterial isolates. the minimal inhibitory concentration (mic) of tobramycin was fourfold less than the mic of gentamicin against most of 119 pseudomonas organisms. gentamicin and tobramycin had similar in vitro activity against enterobacteriaceae and staphylococcus aureus. proteus rettgeri were commonly resistant to both tobramycin and gentamicin. the 10-mug tobramycin disc separated resistant (mic >/=5 mu ...	1972	4790564
enterobacteria in feedlot waste and runoff.	samples of beef cattle feedlot waste (flw), runoff from the pens, and water from a large drainage ditch at the feedlot were examined for enterobacteriaceae. the drainage ditch receives the runoff but contains primarily subsurface drainage from fields on which flw is spread for disposal. planting and enrichment techniques with seven different media were used to isolate 553 cultures of enterobacteria. flw contains about 50 million enterobacteria/g dry weight. more than 90% of these were escherichi ...	1972	16349932
sisomicin: evaluation in vitro and comparison with gentamicin and tobramycin.	sisomicin is a new antibiotic produced by micromonospora inyoensis. the in vitro activities of sisomicin, gentamicin, and tobramycin, three similar aminoglycosides, were determined against 228 clinical isolates representing 10 genera of common pathogens. no difference was noted in the activities of these antimicrobial agents when assayed by a standard broth dilution technique against klebsiella, enterobacter, escherichia, salmonella, citrobacter, enterococci, or staphylococcus aureus. sisomicin ...	1973	4790572
microbiological properties of a new cephalosporin, bl-s 339: 7-(phenylacetimidoyl-aminoacetamido)-3-(2-methyl-1,3,4-thiadiazol-5-ylthiomethyl)ceph-3-em-4-carboxylic acid.	bl-s 339 is a new broad-spectrum, parenterally effective cephalosporin whose expression of antibacterial activity in vitro is markedly affected by the nature of the assay medium. when assayed in nutrient agar, bl-s 339 was more active than cephalothin against strains of diplococcus pneumoniae, streptococcus pyogenes, escherichia coli, serratia marcescens, klebsiella pneumoniae, enterobacter, and indole-positive proteus sp. however, when assayed in mueller-hinton medium, its activity, especially ...	1973	4790575
in vitro bactericidal effectiveness of four aminoglycoside antibiotics.	the antibacterial activity of four aminoglycoside antibiotics (gentamicin, sch 13706, tobramycin, and sisomicin) was tested against eight gram-negative and three gram-positive species. a total of 323 strains were studied by the broth dilution technique. tobramycin and sisomicin had greater bacteriostatic and bactericidal activity against pseudomonas strains than did gentamicin and sch 13706. of the four antibiotics, sisomicin was most active against klebsiella, enterobacter, escherichia coli, in ...	1973	4790579
clinical and in vitro evaluation of cefazolin, a new cephalosporin antibiotic.	cefazolin sodium, a cephalosporin for parenteral use, was evaluated in vitro and in 26 patients. cefazolin had activity equivalent to cephalothin against streptococcus pneumoniae, staphylococcus aureus, group a streptococci, and proteus mirabilis. cefazolin was four- to eightfold more active against escherichia coli and slightly more active against klebsiella pneumoniae, whereas cephalothin was slightly more active against indole-positive proteus species. after a 500-mg dose of cefazolin intramu ...	1973	4790584
cephamycins, a new family of beta-lactam antibiotics: antibacterial activity and resistance to beta-lactamase degradation.	the susceptibility to some cephalosporin antibiotics and to cephamycin c, a member of a new family of beta-lactam antibiotics, was evaluated for 466 cultures representing 11 different genera or species of gram-negative clinical isolates. the susceptibility of 39 gram-negative cultures known to produce beta-lactamase was also determined. the beta-lactamase activity of a representative group of the clinical isolates and the 39 enzyme producers was studied with the cephalosporins (cephalothin and c ...	1973	4790591
evaluation of cefazolin, a new cephalosporin antibiotic.	cefazolin sodium was tested in vitro against 308 isolates of enterobacteriaceae, pseudomonas aeruginosa, neisseria meningitidis, haemophilus influenzae, staphylococcus aureus, and enterococcus. broth and agar dilution and disk diffusion techniques were used with at least two sizes of inocula of organisms. cefazolin was also studied in the treatment of 85 hospitalized patients with a variety of serious infections. in concentations of 5 mug or less/ml, cefazolin inhibited and killed more than 90% ...	1973	4790605
antibacterial activity of cefamandole, a new cephalosporin antibiotic, compared with that of cephaloridine, cephalothin, and cephalexin.	the in vitro antibacterial activity of cefamandole, a new cephalosporin antibiotic, was compared with that of cephaloridine, cephalothin, and cephalexin against 1,213 strains of gram-positive and gram-negative bacteria recently isolated from clinical sources. the decreasing order of activity of the four agents against gram-positive cocci was cephaloridine, cephalothin, cefamandole, and cephalexin. however, cefamandole was the most active of the four against haemophilus species and gram-negative ...	1973	4790616
in vitro studies of bb-k8, a new aminoglycoside antibiotic.	bb-k8, an aminoglycoside antibiotic which is a derivative of kanamycin, was tested in vitro against 466 clinical bacterial isolates. over 90% of gram-negative bacilli, except proteus spp., were inhibited by 3.12 mug of bb-k8 per ml. this antibiotic was consistently more active than kanamycin but less active than tobramycin or gentamicin. unlike kanamycin, bb-k8 was active against pseudomonas aeruginosa. eleven of 19 isolates resistant to either gentamicin or tobramycin, or both, were susceptible ...	1973	4790938