Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| mitochondrial dna diversity of feral pigs from karukinka natural park, tierra del fuego island, chile. | control or eradication of exotic species is one of the greatest challenges facing biodiversity and ecosystem conservation. domestic pigs (sus scrofa domestica) were released and became feral in the southern region of chilean tierra del fuego island in the 1900s. currently, they inhabit part of karukinka natural park, an area of global conservation concern. to gain insight into the control of this invasive species, we analyzed genetic variation in the mitochondrial dna control region to determine ... | 2015 | 25966196 |
| expression of vpac1 receptor at the level of mrna and protein in the porcine female reproductive system. | the presence and distribution of vasoactive intestinal polypeptide (vip) receptor vpac1 was studied in the ovary, oviduct and uterus (uterine horn and cervix) of the domestic pig using methods of molecular biology (rt-pcr and immunoblot) and immunohistochemistry. the expression of vpac1 receptor at mrna level was confirmed with rt-pcr in all the studied parts of the porcine female reproductive system by the presence of 525 bp pcr product and at the level of proteins by the detection of 46 kda pr ... | 2015 | 25928928 |
| fluid dynamics simulation of right ventricular outflow tract oversizing. | repair of the right ventricular outflow tract (rvot) in paediatric cardiac surgery remains challenging due to the high reoperation rate. intimal hyperplasia and consequent arteriosclerosis is one of the most important limitation factors for graft durability. since local shear stress and pressure are predictive elements for intimal hyperplasia and wall degeneration, we sought to determine in an oversized 12-mm rvot model, with computed fluid dynamics simulation, the local haemodynamical factors t ... | 2015 | 25912476 |
| real-time in-vivo imaging of pulmonary capillary perfusion using probe-based confocal laser scanning endomicroscopy in pigs: an interventional laboratory study. | little is known about real-time in-vivo microscopy of pulmonary capillary perfusion because current microscopy requires direct access to lung tissue with surgical intervention such as the thoracic-window technique and open-lung model. | 2015 | 25906262 |
| tvp1022: a novel cardioprotective drug attenuates left ventricular remodeling after ischemia/reperfusion in pigs. | the current cornerstone treatment of myocardial infarction (mi) is restoration of coronary blood flow by means of thrombolytic therapy or primary percutaneous coronary intervention. however, reperfusion of ischemic myocardium can actually provoke tissue damage, defined as "ischemia-reperfusion (i/r) injury." tvp1022 [the s-isomer of rasagiline (azilect), fda-approved anti-parkinson's drug] was found to exert cardioprotective activities against various cardiac insults, such as chronic heart failu ... | 2015 | 25900266 |
| pluripotent and metabolic features of two types of porcine ipscs derived from defined mouse and human es cell culture conditions. | the domestic pig is an excellent animal model for stem cell research and clinical medicine. there is still no suitable culture condition to generate authentic porcine embryonic stem cells (pescs) and high quality porcine induced pluripotent stem cells (pipscs). in this study, we found that culture conditions affected pluripotent and metabolic features of pipscs. using defined human embryonic stem cell (hesc) and mouse esc (mesc) culture conditions, we generated two types of pipscs, one of which ... | 2015 | 25893435 |
| development of a new lamp assay for the detection of csfv strains from cuba: a proof-of-concept study. | classical swine fever (csf) is a devastating animal disease of great economic impact worldwide. in many countries, csf has been endemic for decades, and vaccination of domestic pigs is one of the measures to control the disease. consequently, differentiating infected from vaccinated animals by antibody elisa screening is not applicable. in some countries, such as cuba, lack of molecular techniques for sensitive, rapid and reliable detection of virus genomes is a critical point. to overcome this ... | 2015 | 25877822 |
| analysis of carcass and meat quality traits and nutritional values of hybrid wild boars under different crossing systems. | the aim of this study was to analyze the results of two crossing systems between wild boars and different domesticated pig breeds. hybrid wild boars were produced by crossing captured wild boars with meishan pigs and ly sows according to the traditional production system. the resultant commercial hybrids were black and white in coat color, respectively. significant differences were found in the carcass and meat quality traits and nutritional values between these two hybrid wild boars. compared w ... | 2015 | 25867408 |
| the effects of altered maxillary growth on patterns of mandibular rotation in a pig model. | a thorough understanding of influence of maxillary growth on patterns of mandibular rotation during development is important with regard to the treatment of skeletal discrepancies. in the present study, we examined whether experimentally altered maxillary position has a significant influence on patterns of mandibular rotation in a pig model. | 2015 | 25841069 |
| the chimerical genome of isla del coco feral pigs (costa rica), an isolated population since 1793 but with remarkable levels of diversity. | the history of domestic species and of their wild ancestors is not a simple one, and feral processes can clarify key aspects of this history, including the adaptive processes triggered by new environments. here, we provide a comprehensive genomic study of isla del coco (costa rica) feral pigs, a unique population that was allegedly founded by two individuals and has remained isolated since 1793. using snp arrays and genome sequencing, we show that cocos pigs are hybrids between asian and europea ... | 2015 | 25827466 |
| flexible growing rods: a pilot study to determine if polymer rod constructs may provide stability to skeletally immature spines. | surgical treatments for early onset scoliosis (eos), including growing rod constructs, involve many complications. some are due to biomechanical factors. a construct that is more flexible than current instrumentation systems may reduce complications. the purpose of this preliminary study was to determine spine range of motion (rom) after implantation of simulated growing rod constructs with a range of clinically relevant structural properties. the hypothesis was that rom of spines instrumented w ... | 2015 | 25810752 |
| wild boars from sweden, austria, the czech republic and japan possess intact mannose-binding lectin 2 (mbl2) genes. | the two-nucleotide deletion recently detected in the mannose-binding lectin 2 gene in purebred and crossbred domestic pigs was not found among 68 wild boars representing 4 populations from europe and asia. this suggests that the deletion is a result of breeding and/or genetic drift/bottle necks. | 2015 | 25809846 |
| atrial fibrillation complicated by heart failure induces distinct remodeling of calcium cycling proteins. | atrial fibrillation (af) and heart failure (hf) are two of the most common cardiovascular diseases. they often coexist and account for significant morbidity and mortality. alterations in cellular ca2+ homeostasis play a critical role in af initiation and maintenance. this study was designed to specifically elucidate af-associated remodeling of atrial ca2+ cycling in the presence of mild hf. af was induced in domestic pigs by atrial burst pacing. the animals underwent electrophysiologic and echoc ... | 2015 | 25775120 |
| establishing a reproducible hypertrophic scar following thermal injury: a porcine model. | our complete understanding of hypertrophic scarring is still deficient, as portrayed by the poor clinical outcomes when treating them. to address the need for alternative treatment strategies, we assess the swine animal burn model as an initial approach for immature scar evaluation and therapeutic application. | 2015 | 25750848 |
| crimped braided sleeves for soft, actuating arm in robotic abdominal surgery. | this paper investigates different types of crimped, braided sleeve used for a soft arm for robotic abdominal surgery, with the sleeve required to contain balloon expansion in the pneumatically actuating arm while it follows the required bending, elongation and diameter reduction of the arm. | 2015 | 25744663 |
| effectiveness of microsatellite and single nucleotide polymorphism markers for parentage analysis in european domestic pigs. | parentage analysis and individual identification are recent, promising methods that have been applied to evolutionary and ecological studies, as well as conservation management. parental exclusion relying on polymorphic microsatellites has been used worldwide in parentage determination, while the low mutation rate and genotyping error rate of single nucleotide polymorphisms (snps) make them another important marker for pedigree tracing. here, we compared the effectiveness of microsatellites and ... | 2015 | 25730075 |
| evidence for a link between tail biting and central monoamine metabolism in pigs (sus scrofa domestica). | tail biting in pigs is a major welfare problem within the swine industry. even though there is plenty of information on housing and management-related risk factors, the biological bases of this behavioral problem are poorly understood. the aim of this study was to investigate a possible link between tail biting, based on behavioral recordings of pigs during an ongoing outbreak, and certain neurotransmitters in different brain regions of these pigs. we used a total of 33 pigs at a farm with a lon ... | 2015 | 25728243 |
| reply to 'on genetic differentiation between domestic pigs and tibetan wild boars'. | 2015 | 25711862 | |
| on genetic differentiation between domestic pigs and tibetan wild boars. | 2015 | 25711861 | |
| [regularity of agonal respiration after untreated cardiac arrest in a swine model]. | to explore the regularity of incidence of agonal respiration (ar) and agonal respiration frequency rate (arfr) during untreated cardiac arrest (ca) after ventricular fibrillation (vf) in a swine model. | 2015 | 27318343 |
| pilot in vivo study of an absorbable polydioxanone vena cava filter. | the objectives of this study were to evaluate tensile strength retention of polydioxanone as a function of time in a swine venous system and to assess the feasibility of an absorbable inferior vena cava (ivc) filter made from polydioxanone in a pilot swine study. | 2015 | 26992619 |
| first detection of sarcoptic mange in free-ranging wild boar (sus scrofa) in switzerland. | in switzerland sarcoptic mange is frequent in free-ranging wild carnivores but until recent years no cases had been recorded in wild ungulates. since 2010, cases have been observed in wild boar in the cantons of solothurn, tessin and thurgau. here, we report the detection of mange-like skin lesions in wild boars by photo-trapping and the post-mortem findings in 6 culled animals presenting different stages of the disease. potential sources of infection include mangy red foxes, outdoor domestic pi ... | 2015 | 26753342 |
| heart rate variability in porcine progressive peritonitis-induced sepsis. | accumulating evidence suggests that heart rate variability (hrv) alterations could serve as an indicator of sepsis progression and outcome, however, the relationships of hrv and major pathophysiological processes of sepsis remain unclear. therefore, in this experimental study hrv was investigated in a clinically relevant long-term porcine model of severe sepsis/septic shock. hrv was analyzed by several methods and the parameters were correlated with pathophysiological processes of sepsis. in 16 ... | 2015 | 26779039 |
| volume infusion cooling increases end-tidal carbon dioxide and results in faster and deeper cooling during intra-cardiopulmonary resuscitation hypothermia induction. | intra-arrest hypothermia induction may provide more benefit than inducing hypothermia after return of spontaneous circulation. however, little is understood about the interaction between patient physiology and hypothermia induction technology choice during ongoing chest compressions. | 2015 | 26715581 |
| shifts in soil biodiversity-a forensic comparison between sus scrofa domesticus and vegetation decomposition. | in a forensic context, microbial-mediated cadaver decomposition and nutrient recycling cannot be overlooked. as a result, forensic ecogenomics research has intensified to gain a better understanding of cadaver/soil ecology interactions as a powerful potential tool for forensic practitioners. for this study, domestic pig (sus scrofa domesticus) (4g) and grass (agrostis/festuca spp) cuttings (4g) were buried (july 2013 to july 2014) in sandy clay loam (80 g) triplicates in sealed microcosms (127 m ... | 2015 | 26654074 |
| an initial investigation into the ecology of culturable aerobic postmortem bacteria. | postmortem microorganisms are increasingly recognized for their potential to serve as physical evidence. yet, we still understand little about the ecology of postmortem microbes, particularly those associated with the skin and larval masses. we conducted an experiment to characterize microbiological and chemical properties of decomposing swine (sus scrofa domesticus) carcasses on the island of oahu, hawaii, usa, during june 2013. bacteria were collected from the head, limb, and larval mass durin ... | 2015 | 26654073 |
| african swine fever: a global view of the current challenge. | african swine fever (asf) is an important contagious haemorrhagic viral disease affecting swine whose notification is mandatory due to its high mortality rates and the great sanitary and socioeconomic impact it has on international trade in animal and swine products. this disease only affects porcine species, both wild and domestic, and produces a variety of clinical signs such as fever and functional disorders of the digestive and respiratory systems. lesions are mainly characterized by congest ... | 2015 | 28405426 |
| establishment of a new pull-out strength testing method to quantify early osseointegration-an experimental pilot study. | the animal study aims to evaluate a new experimental model for measuring sole the influence of the surface characteristics independent from implant macro-design on the level of osseointegration by registering the pull-out strength needed for removal of experimental devices with different surfaces from artificial defects. | 2015 | 26616405 |
| the control of classical swine fever in wild boar. | classical swine fever (csf) is a viral disease with severe economic consequences for domestic pigs. natural hosts for the csf virus (csfv) are members of the family suidae, i.e., eurasian wild boar (sus scrofa) are also susceptible. csf in wild boar poses a serious threat to domestic pigs. csfv is an enveloped rna virus belonging to the pestivirus genus of the flaviviridae family. transmission of the infection is usually by direct contact or by feeding of contaminated meat products. in recent de ... | 2015 | 26594202 |
| effects of amlodipine and perindoprilate on the structure and function of mitochondria in ventricular cardiomyocytes during ischemia-reperfusion in the pig. | the aim of this study was to determine whether amlodipine and/or perindoprilate injected intravenously (iv) prior to ischemia exerted protective effects on mitochondria structural and functional alterations induced by ischemia and aggravated by reperfusion. heart rate, the duration of monophasic action potentials (dmap), peak of the time derivative of left ventricular pressure (lv dp/dt max), mitochondria structural and functional parameters in the left ventricle ischemic area were measured afte ... | 2015 | 24588464 |
| immunohistochemical analysis of blood vessels in peri-implant mucosa: a comparison between mini-incision flapless and flap surgeries in domestic pigs. | the aim of this experimental study is to compare the effect of mini-incision flapless versus flap technique of implant placement on the amount of vascular structures and blood vessel elements in peri-implant soft tissue, using immunohistochemical analysis. | 2015 | 24438481 |
| computed tomography for planning and postoperative imaging of transvenous mitral annuloplasty: first experience in an animal model. | to investigate the use of computed tomography (ct) to measure the mitral valve annulus size before implantation of a percutaneous mitral valve annuloplasty device in an animal trial. seven domestic pigs underwent ct before and after implantation of a cardioband™ (a percutaneously implantable mitral valve annuloplasty device) with a second-generation 128-section dual-source ct machine. implantation of the cardioband™ was performed in a standard fashion according to a protocol. animals were sacrif ... | 2015 | 25119889 |
| qualitative tissue differentiation by analysing the intensity ratios of atomic emission lines using laser induced breakdown spectroscopy (libs): prospects for a feedback mechanism for surgical laser systems. | the research work presented in this paper focuses on qualitative tissue differentiation by monitoring the intensity ratios of atomic emissions using 'laser induced breakdown spectroscopy' (libs) on the plasma plume created during laser tissue ablation. the background of this study is to establish a real time feedback control mechanism for clinical laser surgery systems during the laser ablation process. ex-vivo domestic pig tissue samples (muscle, fat, nerve and skin) were used in this experimen ... | 2015 | 24376030 |
| preclinical randomised safety, efficacy and physiologic study of the silicon dioxide inert-coated axetis and bare metal stent: short-, mid- and long-term outcome. | to evaluate the short-, mid- and long-term safety, efficacy and vascular physiology of axetis silicon dioxide (sio2, abrading the micropores) inert-coated stent implantation in a randomised preclinical setting. | 2015 | 24769439 |
| dynamic changes in nuclear import of a nuclear localisation signal-bearing substrate in 8-cell stage porcine embryos. | coordinated intracellular trafficking is critically important for proper timing of major cellular events during embryogenesis. nuclear import mediated by the karyopherin α/β (importin α/β) heterodimer is perhaps the best characterised nuclear trafficking system in eukaryotic cells. seven karyopherin α subtypes have been identified in the domestic pig, and although each karyopherin α subtype transports proteins bearing classical nuclear localisation signals (nlss), individual karyopherin α subtyp ... | 2015 | 24342392 |
| dental implant macro-design features can impact the dynamics of osseointegration. | the purpose of this study was to compare the clinical performance of two dental implant types possessing a different macro-design in the in vivo pig model. | 2015 | 24238310 |
| assessing the risk of african swine fever introduction into the european union by wild boar. | the presence of african swine fever (asf) in the caucasus region and russian federation has increased concerns that wild boars may introduce the asf virus into the european union (eu). this study describes a semi-quantitative approach for evaluating the risk of asf introduction into the eu by wild boar movements based on the following risk estimators: the susceptible population of (1) wild boars and (2) domestic pigs in the country of origin; the outbreak density in (3) wild boars and (4) domest ... | 2015 | 23926953 |
| radiologic advantages of potential use of polymer plastic clips in neurosurgery. | plastic clips are made of diamagnetic material and may result in fewer computed tomography (ct) and magnetic resonance artifacts than titanium clips. considering that polymer plastic clips are increasingly being used in endoscopic surgery, our study examined the ct and magnetic resonance imaging (mri) characteristics of plastic clips after application in the neurocranium and compared them with titanium clips. | 2016 | 24067738 |
| detecting mitochondrial signatures of selection in wild tibetan pigs and domesticated pigs. | selection in genomic regions is prevalent in mammals; however, the effects of selection on the mitogenome are not clearly understood. we determined the complete mitochondrial dna (mtdna) sequences from six wild tibetan pigs from the tibetan plateau and four domestic pig breeds from the lowland of neighboring southwest china. nucleotide diversity analysis using the sliding window method showed that the nucleotide diversity of wild tibetan pigs in most regions of the mitogenome was higher than tha ... | 2016 | 24810064 |
| effect of elevated reperfusion pressure on "no reflow" area and infarct size in a porcine model of ischemia-reperfusion. | the "no reflow" phenomenon (microvascular obstruction despite restoration of epicardial blood flow) develops postreperfusion in acute myocardial infarction and is associated with poor prognosis. we hypothesized that increased reperfusion pressure may attenuate the no reflow phenomenon, as it could provide adequate flow to overcome the high resistance of the microvasculature within the no reflow zone. thus, we investigated the effect of modestly elevated blood pressure during reperfusion on the e ... | 2016 | 26589289 |
| pervasive environmental contamination with human feces results in high prevalence of zoonotic sarcocystis infection in pigs in the punjab, india. | three species of sarcocystis-s. miescheriana, s. suihominis, and s. porcifelis-have been recorded from pigs ( sus scrofa ). among these 3 species, the zoonotic species s. suihominis is of paramount importance and an important food safety issue. previous studies indicate prevalence of porcine sarcocystis species in india, but molecular evidence, among other evidence, is required for proper species differentiation. myocardium from 250 stray and farm pigs destined for slaughter for human consumptio ... | 2016 | 26588086 |
| articular cartilage repair with recombinant human type ii collagen/polylactide scaffold in a preliminary porcine study. | the purpose of this study was to investigate the potential of a novel recombinant human type ii collagen/polylactide scaffold (rhco-pla) in the repair of full-thickness cartilage lesions with autologous chondrocyte implantation technique (aci). the forming repair tissue was compared to spontaneous healing (spontaneous) and repair with a commercial porcine type i/iii collagen membrane (pco). domestic pigs (4-month-old, n = 20) were randomized into three study groups and a circular full-thickness ... | 2016 | 26573959 |
| fractional radiofrequency combined with sonophoresis to facilitate skin penetration of 5-aminolevulinic acid. | ablative fractional technology has been used to improve transdermal drug delivery. however, there have been few previous in vivo investigations of the relative potency and methodology of fractional radiofrequency (rf) combined with sonophoresis. the purpose of this study was to investigate the effects of fractional rf combined with sonophoresis on 5-aminolevulinic acid (ala) penetration of the skin. three male domestic swine were used. the skin of the pigs was exposed to fractional rf and/or son ... | 2016 | 26563955 |
| a novel hemostatic patch that stops bleeding in cardiovascular and peripheral vascular procedures. | achieving hemostasis during surgery is a common challenge across surgical specialties and procedures, including cardiovascular and peripheral vascular procedures. although several hemostatic agents are available, they all become less effective as bleeding becomes more vigorous. veriset™ hemostatic patch is a topical hemostatic agent that has been approved for use on solid organs and in soft tissue. the primary aim of these studies was to assess the safety of veriset hemostatic patch during cardi ... | 2016 | 26597233 |
| implantation of a tissue-engineered neo-bile duct in domestic pigs. | extrahepatic bile duct injuries remain severe complications during cholecystectomies and often require reconstruction by bilioenteric anastomosis (i.e., hepaticojejunostomy), which comes with further long-term complications (e.g., recurring ascending cholangitis, secondary biliary cirrhosis). in the case of inherent extrahepatic biliary atresia or during liver transplant, artificial or engineered bile ducts could allow novel surgical strategies without the need for hepaticojejunostomy. | 2016 | 26684913 |
| large-scale screening and characterization of enteroviruses and kobuviruses infecting pigs in vietnam. | a recent survey of pigs in dong thap province, vietnam identified a high frequency of enterovirus species g (ev-g) infection (144/198; 72.7%). amongst these was a plethora of ev-g types (ev-g1, ev-g6 and four new types ev-g8-ev-g11). to better characterize the genetic diversity of ev-g and investigate the possible existence of further circulating types, we performed a larger-scale study on 484 pig and 45 farm-bred boar faecal samples collected in 2012 and 2014, respectively. all samples from the ... | 2016 | 26653281 |
| assessing the accuracy of cone-beam computerized tomography in measuring thinning oral and buccal bone. | the aim of this study was to assess the accuracy and reliability of cone-beam computerized tomography (cbct) in measuring thinning bone surrounding dental implants. three implants were inserted into the mandible of a domestic pig at 6 different bone thicknesses on the vestibular and the lingual sides, and measurements were recorded using cbct. the results were obtained, analyzed, and compared with areas without implants. our results indicated that the bone thickness and the neighboring implants ... | 2016 | 26645480 |
| surgical implantation and functional assessment of an invasive telemetric system to measure autonomic responses in domestic pigs. | the first aim of this study was to establish a surgical procedure to implant a new telemetric device for the continuous recording of electrocardiogram (ecg) and blood pressure (bp) in freely moving pigs. a second aim was the functional assessment of cardiovascular parameters, including heart rate variability (hrv) and blood pressure variability (bpv), so that these data could be used as the basis for the objective evaluation of autonomic activity and balance in different behavioural contexts. el ... | 2016 | 26626089 |
| an implantable sensor device measuring suture tension dynamics: results of developmental and experimental work. | knowledge about suture tension dynamics after laparotomy closure is limited due to the lack of adequate measurement tools. as a consequence, a miniaturized implantable sensor and data logger were developed and applied experimentally in a porcine model to measure suture tension dynamics after laparotomy closure. | 2016 | 26621138 |
| closed-loop glycaemic control using an implantable artificial pancreas in diabetic domestic pig (sus scrofa domesticus). | the performance of a completely implantable peritoneal artificial pancreas (ap) has been demonstrated in principle in a live diabetic domestic pig. the device consists of a smart glucose-sensitive gel that forms a gateway to an insulin reservoir and is designed to both sense glucose and deliver insulin in the peritoneal cavity. it can be refilled with insulin via subcutaneous ports and surgery was developed to insert the ap. diabetes was induced with streptozotocin (stz), the device filled with ... | 2016 | 26691655 |
| comparison of complement activation-related pseudoallergy in miniature and domestic pigs: foundation of a validatable immune toxicity model. | complement activation-related pseudoallergy (carpa) is an acute adverse immune reaction caused by many nanomedicines. there is a regulatory need for a sensitive and standardizable in vivo predictive assay. while domestic pigs are a sensitive animal model, miniature pigs are favored in toxicological studies yet their utility as a carpa model has not yet been explored. herein, we used liposomal doxorubicin and amphotericin b (doxil/caelyx and ambisome), cremophor el and zymosan as carpa triggers t ... | 2016 | 26767512 |
| aortic hemostasis and resuscitation: preliminary experiments using selective aortic arch perfusion with oxygenated blood and intra-aortic calcium coadministration in a model of hemorrhage-induced traumatic cardiac arrest. | selective aortic arch perfusion (saap) uses a thoracic aortic balloon occlusion catheter for heart and brain perfusion in cardiac arrest to achieve return of spontaneous circulation (rosc). saap with oxygenated stored blood was studied in a model of hemorrhage-induced cardiac arrest. the study hypothesis was that intra-aortic calcium coadministration would be required to maintain normal aortic arch blood ionized calcium during saap and to achieve rosc. | 2016 | 26766760 |
| hypercholesterolemia impairs nonstenotic kidney outcomes after reversal of experimental renovascular hypertension. | revascularization of a stenotic renal artery improves kidney function only in select patients with renovascular hypertension (ht) secondary to atherosclerosis. however, the effects of reversal of renovascular ht (rrht) on the nonstenotic kidney are unclear. we hypothesized that concurrent hypercholesterolemia (hc) attenuates nonstenotic kidney recovery. | 2016 | 26739189 |
| the swine plasma metabolome chronicles "many days" biological timing and functions linked to growth. | the paradigm of chronobiology is based almost wholly upon the daily biological clock, or circadian rhythm, which has been the focus of intense molecular, cellular, pharmacological, and behavioral, research. however, the circadian rhythm does not explain biological timings related to fundamental aspects of life history such as rates of tissue/organ/body size development and control of the timing of life stages such as gestation length, age at maturity, and lifespan. this suggests that another bio ... | 2016 | 26735517 |
| detection and genetic characterization of a novel parvovirus distantly related to human bufavirus in domestic pigs. | in this study, a novel parvovirus (strain swine/zsana3/2013/hun, kt965075) was detected in domestic pigs and genetically characterized by viral metagenomics and pcr methods. the novel parvovirus was distantly related to the human bufaviruses and was detected in 19 (90.5 %) of the 21 and five (33.3 %) of the 15 faecal samples collected from animals with and without cases of posterior paraplegia of unknown etiology from five affected farms and one control farm in hungary, respectively. swine/zsana ... | 2016 | 26733298 |
| serological prevalence of enteropathogenic yersinia spp. in pigs and wild boars from different production systems in the moravian region, czech republic. | human yersiniosis caused by pathogenic yersinia spp. is one of the most common reported zoonoses in the european union and pigs are considered as the major reservoir of these bacteria. serological testing represents a suitable method to obtain information about the prevalence of enteropathogenic yersinia spp. in food animals. the prevalence of antibodies against enteropathogenic yersinia spp. was studied in 319 slaughtered pigs and 135 wild boars from different production systems in the moravian ... | 2016 | 26982547 |
| cellular cardiomyoplasty into infracted swine's hearts by retrograde infusion through the venous coronary sinus: an experimental study. | the aim was to create a model of myocardial infarction with a borderline myocardial impairment which would enable evaluation of the retrograde cellular cardiomyoplasty through the venous coronary sinus in a large animal model. | 2016 | 26953214 |
| gelatin-poly(lactic-co-glycolic acid) scaffolds with oriented pore channel architecture - from in vitro to in vivo testing. | a gelatin-poly(lactic-co-glycolic acid), plga, composite scaffold, featuring a highly oriented pore channel structure, was developed as a template for articular cartilage regeneration. as a design principle the composite scaffold was optimized to contain only medical grade educts and accordingly no chemical cross linking agents or other toxicological relevant substances or methods were used. scaffolds were synthesized using a freeze structuring method combined with an electrochemical process fol ... | 2016 | 26952462 |
| the effect of head up cardiopulmonary resuscitation on cerebral and systemic hemodynamics. | chest compressions during cardiopulmonary resuscitation (cpr) increase arterial and venous pressures, delivering simultaneous bidirectional high-pressure compression waves to the brain. we hypothesized that this may be detrimental and could be partially overcome by elevation of the head during cpr. | 2016 | 26905388 |
| early atherosclerosis aggravates renal microvascular loss and fibrosis in swine renal artery stenosis. | renal function in patients with atherosclerosis and renal artery stenosis (aras) deteriorates more frequently than in nonatherosclerotic ras. we hypothesized that aras aggravates stenotic-kidney micro vascular loss compared to ras. domestic pigs were randomized to normal, ras, and aras (ras fed a high-cholesterol diet) groups (n = 7 each). ten weeks later stenotic-kidney oxygenation, renal blood flow, and glomerular filtration rate (gfr) were evaluated in vivo, and micro vascular density by micr ... | 2016 | 26879682 |
| behavioural and physiological measures indicate subtle variations in the emotional valence of young pigs. | in the study of animal emotions, emotional valence has been found to be difficult to measure. many studies of farm animals' emotions have therefore focussed on the identification of indicators of strong, mainly negative, emotions. however, subtle variations in emotional valence, such as those caused by rather moderate differences in husbandry conditions, may also affect animals' mood and welfare when such variations occur consistently. in this study, we investigated whether repeated moderate ave ... | 2016 | 26850291 |
| argon and xenon ventilation during prolonged ex vivo lung perfusion. | evidence supports the use of ex vivo lung perfusion (evlp) as a platform for active reconditioning before transplantation to increase the potential donor pool and to reduce the incidence of primary graft dysfunction. a promising reconditioning strategy is the administration of inhaled noble gases based on their organoprotective effects. our aim was to validate a porcine warm ischemic lung injury model and investigate postconditioning with argon (ar) or xenon (xe) during prolonged evlp. | 2016 | 26850183 |
| novel roles for kv7 channels in shaping histamine-induced contractions and bradykinin-dependent relaxations in pig coronary arteries. | voltage-gated kv7 channels are inhibited by agonists of gq-protein-coupled receptors, such as histamine. recent works have provided evidence that inhibition of vascular kv7 channels may trigger vessel contractions. in this study, we investigated how kv7 activity modulates the histamine-induced contractions in "healthy" and metabolic syndrome (mets) pig right coronary arteries (cas). we performed isometric tension and immunohistochemical studies with domestic, lean ossabaw, and mets ossabaw pig c ... | 2016 | 26844882 |
| minipigs in translational immunosafety sciences: a perspective. | the porcine immune system has been studied especially with regard to infectious diseases of the domestic pig, highlighting the economic importance of the pig in agriculture. recently, in particular, minipigs have received attention as alternative species to dogs or nonhuman primates in drug safety evaluations. the increasing number of new drug targets investigated to modulate immunological pathways has triggered renewed interest to further explore the porcine immune system. comparative immunolog ... | 2016 | 26839327 |
| blood lactate concentrations in göttingen minipigs compared with domestic pigs. | measurement of the blood lactate concentration is a useful monitoring tool during anesthesia of animals and people. recently, blood lactate has been used to monitor anesthetized pigs, but very little is known about variations in blood lactate concentrations in this species. we therefore evaluate the effects of breed (domestic pigs compared with göttingen minipigs), body weight (domestic pigs of 40 kg compared with 70 kg), type of anesthesia (inhalation compared with infusion) and surgery (minor ... | 2016 | 26817974 |
| electrical impedance tomography (eit) for quantification of pulmonary edema in acute lung injury. | assessment of pulmonary edema is a key factor in monitoring and guidance of therapy in critically ill patients. to date, methods available at the bedside for estimating the physiologic correlate of pulmonary edema, extravascular lung water, often are unreliable or require invasive measurements. the aim of the present study was to develop a novel approach to reliably assess extravascular lung water by making use of the functional imaging capabilities of electrical impedance tomography. | 2016 | 26796635 |
| aortic root haemodynamics following david procedure: numerical analysis of 3-dimensional haemodynamics. | the aim was to determine 3-dimensional (3d) geometrical deformation of the aortic root (aor) following the david procedure in order to evaluate local haemodynamical conditions of individual aor elements. | 2016 | 26792930 |
| pegivirus infection in domestic pigs, germany. | 2016 | 27314228 | |
| using 300 pretreatment shock waves in a voltage ramping protocol can significantly reduce tissue injury during extracorporeal shock wave lithotripsy. | pretreating a pig kidney with 500 low-energy shock waves (sws) before delivering a clinical dose of sws (2000 sws, 24 kv, 120 sws/min) has been shown to significantly reduce the size of the hemorrhagic lesion produced in that treated kidney, compared with a protocol without pretreatment. however, since the time available for patient care is limited, we wanted to determine if fewer pretreatment sws could be used in this protocol. as such, we tested if pretreating with 300 sws can initiate the sam ... | 2016 | 27307070 |
| search for a reliable model for bisphosphonate-related osteonecrosis of the jaw: establishment of a model in pigs and description of its histomorphometric characteristics. | the pathogenesis of bisphosphonate-related osteonecrosis of the jaw (bronj) remains unknown, and the development of a reliable experimental model would help to improve our understanding of it. we used 12 domestic pigs of which 6 made up the experimental group and were treated with zoledronate 4mg intravenously weekly for 5 weeks, while the control group (n=6) were given no drugs. on day 60 the right second maxillary and mandibular third molars were extracted. thirty days later 3 animals in each ... | 2016 | 27282083 |
| microwave versus saline-linked radiofrequency (aquamantys) assisted liver resection in a porcine liver resection model. a safety and feasibility pilot study. | the aim of this study was to compare the feasibility, efficacy and safety of microwave ablation and saline-linked radiofrequency (aquamantys) in liver resection. | 2016 | 27273952 |
| targeted gene knockin in porcine somatic cells using crispr/cas ribonucleoproteins. | the pig is an ideal large animal model for genetic engineering applications. a relatively short gestation interval and large litter size makes the pig a conducive model for generating and propagating genetic modifications. the domestic pig also shares close similarity in anatomy, physiology, size, and life expectancy, making it an ideal animal for modeling human diseases. often, however, the technical difficulties in generating desired genetic modifications such as targeted knockin of short stre ... | 2016 | 27240344 |
| endoscopic ultrasound guided injection of iron oxide magnetic nanoparticles for liver and pancreas: a feasibility study in pigs. | pancreatic cancer and hepatocellular carcinoma are two of the most aggressive types of cancer with limited therapeutic options in stages of advanced disease. our objective is to assess the safety and feasibility of injecting iron oxide nanoparticles (ions) via endoscopic ultrasound (eus)-guidance, both systemically and locally in the liver and pancreas in order to study new potential therapies for liver and pancreatic tumors. | 2016 | 27239648 |
| omental flow-through flap: experimental hemodynamic study. | the omental flow-through flap (oftf) is based on the use of an anatomic unit composed of the right gastro-omental artery (bypass) with its omental branch or branches supplying the greater omentum (flap). the greater omentum flap is known for its capacity of resistance to infection, for its use in the treatment of ischemic lesions and as a high-flow tissue. several hypotheses regarding the hemodynamic behavior of a distal bypass with a flap were discussed in the literature. we made the assumption ... | 2016 | 27238991 |
| reperfusion injury protection during basic life support improves circulation and survival outcomes in a porcine model of prolonged cardiac arrest. | ischemic postconditioning (pc) using three intentional pauses at the start of cardiopulmonary resuscitation (cpr) improves outcomes after cardiac arrest in pigs when epinephrine (epi) is used before defibrillation. we hypothesized pc, performed during basic life support (bls) in the absence of epinephrine, would reduce reperfusion injury and enhance 24h functional recovery. | 2016 | 27211835 |
| peri-implant defect regeneration in the diabetic pig: a preclinical study. | the study aims to establish a peri-implant dehiscence-type bone defect in a diabetic animal model of human bone repair and to quantify the influence of diabetes on peri-implant bone regeneration. | 2016 | 27209350 |
| functional plasticity of adipose-derived stromal cells during development of obesity. | obesity is a major risk factor for a number of chronic diseases, including diabetes, cardiovascular diseases, and cancer. expansion of the adipose mass requires adipocyte precursor cells that originate from multipotent adipose-derived stromal cells (ascs), which in turn also participate in repair activities. asc function might decline in a disease milieu, but it remains unclear whether asc function varies during the development of obesity. we tested the hypothesis that microenvironmental inflamm ... | 2016 | 27177576 |
| influence of chest compressions on circulation during the peri-cardiac arrest period in porcine models. | starting chest compressions immediately after a defibrillation shock might be harmful, if the victim already had a return of spontaneous circulation (rosc) and yet was still being subjected to external compressions at the same time. the objective of this study was to study the influence of chest compressions on circulation during the peri-cardiac arrest period. | 2016 | 27168071 |
| intranasal oxytocin administration in relationship to social behaviour in domestic pigs. | intranasal administration of oxytocin has been shown to alter positive and negative social behaviour. positive social behaviour in pigs (sus scrofa) may be expressed through gentle social nosing, and greater insight in the specific expression hereof might contribute to the current search for positive indicators of animal welfare. we investigated whether oxytocin alters social nosing and whether this is specific to nose-body or nose-nose contact. sixty-four focal female pigs of 13weeks of age (ou ... | 2016 | 27143253 |
| complete antegrade transapical deployment of a branched aortic arch endograft: a porcine feasibility study. | to describe and prove the concept of a technique for complete transapical deployment of a single-branch aortic arch endograft in a porcine model. | 2016 | 27090167 |
| olfactory sensitivity in mammalian species. | olfaction enables most mammalian species to detect and discriminate vast numbers of chemical structures called odorants and pheromones. the perception of such chemical compounds is mediated via two major olfactory systems, the main olfactory system and the vomeronasal system, as well as minor systems, such as the septal organ and the grueneberg ganglion. distinct differences exist not only among species but also among individuals in terms of their olfactory sensitivity; however, little is known ... | 2016 | 27070753 |
| identification of a novel bufavirus in domestic pigs by a viral metagenomic approach. | bufavirus is a single-stranded dna virus belonging to the genus protoparvovirus. this study reports the identification and characterization of a porcine bufavirus by a metagenomic approach, and a limited epidemiology investigation of bufavirus in six swine farms. a comparative genome analysis showed a similarity of 93 % to a hungarian porcine bufavirus. bayesian and maximum-likelihood analyses of genome sequences showed a close relationship of porcine bufaviruses to human and monkey bufaviruses. ... | 2016 | 27058516 |
| an experimental comparative study on classic tube thoracostomy and thoracostomy with a newly designed thorax drainage catheter. | the collection of fluids, blood, pus, or air in the pleural cavity is a pathological condition requiring pleural drainage. a newly designed thorax drainage catheter in the prototype phase was used in this experimental study to test its efficacy. | 2016 | 27511340 |
| dynamic variables fail to predict fluid responsiveness in an animal model with pericardial effusion. | the reliability of dynamic and volumetric variables of fluid responsiveness in the presence of pericardial effusion is still elusive. the aim of the present study was to investigate their predictive power in a porcine model with hemodynamic relevant pericardial effusion. | 2016 | 27499343 |
| penile injuries in wild and domestic pigs. | in boars, sexually motivated mounting can not only cause problems such as lameness, but penile injuries are also reported. the relevance of penis biting in boars is discussed controversially, but reliable data is missing. in the present study, boars ( n = 435) and barrows ( n = 85) from experimental farms were therefore evaluated for scars, fresh wounds and severe injuries of the penis. similarly, 321 boars from 11 farms specializing in pork production with boars, and 15 sexually mature wild boa ... | 2016 | 27023619 |
| endovascular mr-guided renal embolization by using a magnetically assisted remote-controlled catheter system. | purpose to assess the feasibility of a magnetically assisted remote-controlled (marc) catheter system under magnetic resonance (mr) imaging guidance for performing a simple endovascular procedure (ie, renal artery embolization) in vivo and to compare with x-ray guidance to determine the value of mr imaging guidance and the specific areas where the marc system can be improved. materials and methods in concordance with the institutional animal care and use committee protocol, in vivo renal artery ... | 2016 | 27019290 |
| prevalence and consequences of chromosomal abnormalities in canadian commercial swine herds. | structural chromosome abnormalities are well known as factors that reduce fertility rate in domestic pigs. according to large-scale national cytogenetic screening programs that are implemented in france, it is estimated that new chromosome abnormalities occur at a rate of 0.5 % in fertility-unproven boars. | 2016 | 27620715 |
| simulating the epidemiological and economic effects of an african swine fever epidemic in industrialized swine populations. | african swine fever (asf) is a notifiable infectious disease with a considerable impact on animal health and is currently one of the most important emerging diseases of domestic pigs. asf was introduced into georgia in 2007 and subsequently spread to the russian federation and several eastern european countries. consequently, there is a non-negligible risk of asf spread towards western europe. therefore it is important to develop tools to improve our understanding of the spread and control of as ... | 2016 | 27599924 |
| feasibility of three-dimensional placement of human therapeutic stem cells using the intracerebral microinjection instrument. | the ability to safely place viable intracerebral grafts of human-derived therapeutic stem cells in three-dimensional (3d) space was assessed in a porcine model of human stereotactic surgery using the intracerebral microinjection instrument (imi) compared to a conventional straight cannula. | 2016 | 27593216 |
| urinary bladder matrix scaffolds strengthen esophageal hiatus repair. | laparoscopic repair of the hiatal hernia is associated with a recurrence rate between 12% and 42% depending on the defect size. although the impact of hiatal reinforcement on long-term recurrence remains controversial, the main limitation of this approach has been the risk of adverse events related with the use of synthetic materials in the vicinity of the esophagus. | 2016 | 27565070 |
| technical note: evaluation of a 160-mm/256-row ct scanner for whole-heart quantitative myocardial perfusion imaging. | the authors investigated the performance of a recently introduced 160-mm/256-row ct system for low dose quantitative myocardial perfusion (mp) imaging of the whole heart. this platform is equipped with a gantry capable of rotating at 280 ms per full cycle, a second generation of adaptive statistical iterative reconstruction (asir-v) to correct for image noise arising from low tube voltage potential/tube current dynamic scanning, and image reconstruction algorithms to tackle beam-hardening, cone- ... | 2016 | 27487900 |
| a naturally hypersensitive glucocorticoid receptor elicits a compensatory reduction of hypothalamus-pituitary-adrenal axis activity early in ontogeny. | we comprehensively characterized the effects of a unique natural gain-of-function mutation in the glucocorticoid receptor (gr), grala610val, in domestic pigs to expand current knowledge of the phenotypic consequences of gr hypersensitivity. cortisol levels were consistently reduced in one-week-old piglets, at weaning and in peripubertal age, probably due to a reduced adrenal capacity to produce glucocorticoids (gc), which was indicated by an adrenocortical thinning in grala610val carriers. adren ... | 2016 | 27440422 |
| romanian wild boars and mangalitza pigs have a european ancestry and harbour genetic signatures compatible with past population bottlenecks. | we aimed to analyse the genetic diversity of romanian wild boars and to compare it with that from other wild boar and pig populations from europe and asia. partial sequencing of the mitochondrial encoded cytochrome b (mt-cyb) gene from 36 romanian wild boars and 36 domestic pigs (mangalitza, bazna and vietnamese breeds) showed that the diversity of romanian wild boars and mangalitza pigs is fairly reduced, and that most of the members of these two populations share a common mt-cyb haplotype. bes ... | 2016 | 27418428 |
| coating of intravascular balloon with paclitaxel prevents constrictive remodeling of the dilated porcine femoral artery due to inhibition of intimal and media fibrosis. | here we investigated how a coating of intravascular balloon with paclitaxel (drug-coated balloon; dcb, freeway™) impacted porcine peripheral artery vascular function and remodeling. domestic swine (n = 54) underwent percutaneous overstretch balloon dilation of femoral and iliac arteries, controlled by angiography and optical coherence tomography (oct). paclitaxel tissue uptake was measured at 1 h and 1, 3, and 9 days post-dilation. at these time-points and at 32 ± 2 days, vascular function of th ... | 2016 | 27388164 |
| experimental taphonomy: post-mortem microstructural modifications in sus scrofa domesticus bone. | bone is a highly specialised form of hard and rigid connective tissue whose histological structure undergoes post-mortem modifications. in taphonomic research, histological examination of bone thin sections is used to investigate these post-mortem microstructural changes in skeletal tissues. in this study, diagenetic modifications in pig skeletal remains (sus scrofa domesticus) which were exposed to different taphonomic conditions as part of a long-term, real-time experiment were examined under ... | 2016 | 27368073 |
| comparable vascular response of a new generation sirolimus eluting stents when compared to fluoropolymer everolimus eluting stents in the porcine coronary restenosis model. | novel sirolimus eluting stents (ses) have shown non-inferior clinical outcomes when compared to everolimus eluting stents (ees), however only limited preclinical data have been published. therefore, we evaluate vascular response of a new generation biodegradable polymer ses (bp-ses: alex plus, balton) and fluoropolymer ees (ees: xience pro, abbott) in the porcine coronary restenosis model. | 2016 | 27976797 |
| social support modulates stress-related gene expression in various brain regions of piglets. | the presence of an affiliative conspecific may alleviate an individual's stress response in threatening conditions. however, the mechanisms and neural circuitry underlying the process of social buffering have not yet been elucidated. using the domestic pig as an animal model, we examined the effect of a 4-h maternal and littermate deprivation on stress hormones and on mrna expression of the glucocorticoid receptor (gr), mineralocorticoid receptor (mr), 11ß-hydroxysteroid dehydrogenase (11ß-hsd) ... | 2016 | 27965550 |
| control of african swine fever epidemics in industrialized swine populations. | african swine fever (asf) is a notifiable infectious disease with a high impact on swine health. the disease is endemic in certain regions in the baltic countries and has spread to poland constituting a risk of asf spread toward western europe. therefore, as part of contingency planning, it is important to explore strategies that can effectively control an epidemic of asf. in this study, the epidemiological and economic effects of strategies to control the spread of asf between domestic swine he ... | 2016 | 27938676 |
| somatic cell nuclear transfer followed by cripsr/cas9 microinjection results in highly efficient genome editing in cloned pigs. | the domestic pig is an ideal "dual purpose" animal model for agricultural and biomedical research. with the availability of genome editing tools such as clustered regularly interspaced short palindromic repeat (crispr) and associated nuclease cas9 (crispr/cas9), it is now possible to perform site-specific alterations with relative ease, and will likely help realize the potential of this valuable model. in this article, we investigated for the first time a combination of somatic cell nuclear tran ... | 2016 | 27918485 |
| in-depth proteomic analysis of the porcine retina by use of a four step differential extraction bottom up lc ms platform. | the eye of the house swine (sus scrofa domestica linnaeus, 1758) represents a promising model for the study of human eye diseases encircling neurodegenerative retina disorders that go along with proteomic changes. to provide an in-depth view into the "normal" (untreated & healthy) porcine retina proteome as an important reference, a proteomic strategy has been developed encircling stepwise/differential extraction, lc ms and peptide de novo sequencing. accordingly, pooled porcine retina homogenat ... | 2016 | 27796761 |