Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| high-level antimicrobial efficacy of representative mediterranean natural plant extracts against oral microorganisms. | nature is an unexplored reservoir of novel phytopharmaceuticals. since biofilm-related oral diseases often correlate with antibiotic resistance, plant-derived antimicrobial agents could enhance existing treatment options. therefore, the rationale of the present report was to examine the antimicrobial impact of mediterranean natural extracts on oral microorganisms. five different extracts from olea europaea, mastic gum, and inula viscosa were tested against ten bacteria and one candida albicans s ... | 2014 | 25054150 |
| effect of an oxygenating agent on oral bacteria in vitro and on dental plaque composition in healthy young adults. | oral bacteria live in symbiosis with the host. therefore, when mouthwashes are indicated, selective inhibition of taxa contributing to disease is preferred instead of broad-spectrum antimicrobials. the potential selectivity of an oxygenating mouthwash, ardox-x® (ax), has not been assessed. the aim of this study was to determine the antimicrobial potential of ax and the effects of a twice-daily oral rinse on dental plaque composition. | 2014 | 25101249 |
| effects of adjunctive daily phototherapy on chronic periodontitis: a randomized single-blind controlled trial. | the purpose of this randomized single-blind controlled trial was to elucidate the clinical and antimicrobial effects of daily phototherapy (pt) as an adjunct to scaling and root planing (srp) in patients with chronic periodontitis. | 2014 | 25568808 |
| n-acetylcysteine and the human serum components that inhibit bacterial invasion of gingival epithelial cells prevent experimental periodontitis in mice. | we previously reported that human serum significantly reduces the invasion of various oral bacterial species into gingival epithelial cells in vitro. the aims of the present study were to characterize the serum component(s) responsible for the inhibition of bacterial invasion of epithelial cells and to examine their effect on periodontitis induced in mice. | 2014 | 25568806 |
| shifts in campylobacter species abundance may reflect general microbial community shifts in periodontitis progression. | oral campylobacter species have been found to be associated with periodontitis progression. while the etiological significance of campylobacter rectus is quite established, the association of c. gracilis, c. concisus, and c. curvus with health or disease remains contradictory. | 2014 | 25412608 |
| association between periodontal condition and subgingival microbiota in women during pregnancy: a longitudinal study. | in this study, the gingival conditions and the quantitative detection for aggregatibacter actinomycetemcomitans, fusobacterium nucleatum, porphyromonas gingivalis and prevotella intermedia in pregnant women were determined. | 2014 | 25591021 |
| relationship of clinical and microbiological variables in patients with type 1 diabetes mellitus and periodontitis. | the aim of the study was to analyze how metabolic control of type 1 diabetes is related to clinical and microbiological periodontal parameters. | 2014 | 25294115 |
| microbial signature profiles of periodontally healthy and diseased patients. | to determine microbial profiles that discriminate periodontal health from different forms of periodontal diseases. | 2014 | 25139407 |
| association between polycystic ovary syndrome, oral microbiota and systemic antibody responses. | polycystic ovary syndrome (pcos) is a hormonal disorder of women that not only is the leading cause of infertility but also shows a reciprocal link with oral health. this study aimed to investigate the hypothesis that the levels of putative periodontal pathogens in saliva and their antibody response in serum are elevated in pcos, compared to systemic health. a total of 125 women were included in four groups; 45 women with pcos and healthy periodontium, 35 women with pcos and gingivitis, 25 syste ... | 2014 | 25232962 |
| the presence of cariogenic and periodontal pathogens in the oral cavity of one-year-old infants delivered pre-term with very low birthweights: a case control study. | recently, the dental literature has focused mainly on the microbial colonization of healthy full-term infants and their mothers or caretakers. however, oral microbial acquisition by premature infants has not been adequately investigated, and the correlation between pre-term birth and the presence of cariogenic and periodontal pathogens has not been determined. the aim of this study was to identify the presence and quantities of representative cariogenic and periodontal pathogens in the oral cavi ... | 2014 | 25178742 |
| massive parallel sequencing provides new perspectives on bacterial brain abscesses. | rapid development within the field of massive parallel sequencing (mps) is about to bring this technology within reach for diagnostic microbiology laboratories. we wanted to explore its potential for improving diagnosis and understanding of polymicrobial infections, using bacterial brain abscesses as an example. we conducted a prospective nationwide study on bacterial brain abscesses. fifty-two surgical samples were included over a 2-year period. the samples were categorized as either spontaneou ... | 2014 | 24671797 |
| subgingival bacteria in ghanaian adolescents with or without progression of attachment loss. | this study describes subgingival bacterial profiles associated with clinical periodontal status in ghanaian adolescents with or without progression of attachment loss. | 2014 | 24834145 |
| a periodontitis-associated multispecies model of an oral biofilm. | while single-species biofilms have been studied extensively, we know notably little regarding multispecies biofilms and their interactions. the purpose of this study was to develop and evaluate an in vitro multispecies dental biofilm model that aimed to mimic the environment of chronic periodontitis. | 2014 | 24778902 |
| characterization of aid1, a novel gene involved in fusobacterium nucleatum interspecies interactions. | the oral opportunistic pathogen fusobacterium nucleatum is known to interact with a large number of different bacterial species residing in the oral cavity. it adheres to a variety of gram-positive bacteria, including oral streptococci via the arginine-inhibitable adhesin radd. in this study, we describe a novel protein encoded by the predicted open reading frame fn1253 that appears to play a role in interspecies interactions of f. nucleatum, particularly with oral streptococci and related gram- ... | 2014 | 24643713 |
| the influence of orthodontic fixed appliances on the oral microbiota: a systematic review. | to investigate whether there is scientific evidence to support the hypothesis that the presence of orthodontic fixed appliances influences the oral microbiota. | 2014 | 24945514 |
| bacteriological analysis of necrotic pulp and fistulae in primary teeth. | primary teeth work as guides for the eruption of permanent dentition, contribute for the development of the jaws, chewing process, preparing food for digestion, and nutrient assimilation. treatment of pulp necrosis in primary teeth is complex due to anatomical and physiological characteristics and high number of bacterial species present in endodontic infections. the bacterial presence alone or in association in necrotic pulp and fistula samples from primary teeth of boys and girls was evaluated ... | 2014 | 24676582 |
| transcriptional responses of treponema denticola to other oral bacterial species. | the classic organization by socransky and coworkers categorized the oral bacteria of the subgingival plaque into different complexes. treponema denticola, porphyromonas gingivalis and tannerella forsythia are grouped into the red complex that is highly correlated with periodontal disease. socransky's work closely associates red with orange complex species such as fusobacterium nucleatum and prevotella intermedia but not with members of the other complexes. while the relationship between species ... | 2014 | 24505483 |
| effects of tongue cleaning on bacterial flora in tongue coating and dental plaque: a crossover study. | the effects of tongue cleaning on reconstruction of bacterial flora in dental plaque and tongue coating itself are obscure. we assessed changes in the amounts of total bacteria as well as fusobacterium nucleatum in tongue coating and dental plaque specimens obtained with and without tongue cleaning. | 2014 | 24423407 |
| detection of eight periodontal microorganisms and distribution of porphyromonas gingivalis fima genotypes in chinese patients with aggressive periodontitis. | the microbiologic feature of aggressive periodontitis (agp) in chinese patients has not yet been determined. this study aims to investigate the prevalence of eight periodontal microorganisms and the distribution of the porphyromonas gingivalis fima genotype in a cohort of chinese patients with agp. | 2014 | 23646850 |
| antimicrobial photodynamic efficiency of novel cationic porphyrins towards periodontal gram-positive and gram-negative pathogenic bacteria. | the gram-negative aggregatibacter actinomycetemcomitans and fusobacterium nucleatum are major causative agents of aggressive periodontal disease. due to increase in the number of antibiotic-resistant bacteria, antimicrobial photodynamic therapy (apdt) seems to be a plausible alternative. in this work, photosensitization was performed on gram-positive and gram-negative bacteria in pure culture using new-age cationic porphyrins, namely mesoimidazolium-substituted porphyrin derivative (imp) and pyr ... | 2014 | 24164211 |
| antibacterial action of chlorhexidine/thymol containing varnishes in vitro and in vivo. | the antibacterial activity of two different formulations of a chlorhexidine/thymol varnish should be elucidated in vitro and in vivo. | 2014 | 24738759 |
| combinatorial effects of amoxicillin and metronidazole on selected periodontal bacteria and whole plaque samples. | the aim of the present study was to analyze in vitro the combinatorial effects of the antibiotic combination of amoxicillin plus metronidazole on subgingival bacterial isolates. | 2014 | 24727003 |
| nanoparticle-encapsulated chlorhexidine against oral bacterial biofilms. | chlorhexidine (chx) is a widely used antimicrobial agent in dentistry. herein, we report the synthesis of a novel mesoporous silica nanoparticle-encapsulated pure chx (nano-chx), and its mechanical profile and antimicrobial properties against oral biofilms. | 2014 | 25170958 |
| clinical and microbiological characterization of localized aggressive periodontitis: a cohort study. | localized aggressive periodontitis (lagp) is an infectious periodontal disease which generally affects young people. recent data suggest the involvement of different bacterial species in different populations. the causative bacterial species in israel has never been identified despite a high prevalence of lagp in this population. the objectives of this study were to characterize the bacterial microbiota of periodontal pockets within an israeli lagp population who were also clinically assessed. | 2014 | 24861390 |
| evaluation of periodontal pathogens of the mandibular third molar pericoronitis by using real time pcr. | the aim of this study was to investigate the mandibular third molar pericoronitis flora by using real-time polymerase chain reaction (pcr). | 2014 | 24835305 |
| diverse toll-like receptors mediate cytokine production by fusobacterium nucleatum and aggregatibacter actinomycetemcomitans in macrophages. | toll-like receptors (tlrs) orchestrate a repertoire of immune responses in macrophages against various pathogens. fusobacterium nucleatum and aggregatibacter actinomycetemcomitans are two important periodontal pathogens. in the present study, we investigated tlr signaling regulating cytokine production of macrophages in response to f. nucleatum and a. actinomycetemcomitans. tlr2 and tlr4 are redundant in the production of cytokines (interleukin-6 [il-6] and tumor necrosis factor alpha [tnf-α]) i ... | 2014 | 24566622 |
| biodegradable nanofibrous drug delivery systems: effects of metronidazole and ciprofloxacin on periodontopathogens and commensal oral bacteria. | the purposes of this study were to fabricate biodegradable polydioxanone (pds ii®) electrospun periodontal drug delivery systems (hereafter referred to as matrices) containing either metronidazole (met) or ciprofloxacin (cip) and to investigate the effects of antibiotic incorporation on both periodontopathogens and commensal oral bacteria. | 2014 | 24535074 |
| photodynamic antimicrobial effect of safranine o on an ex vivo periodontal biofilm. | the increasing resistance of oral pathogens against antibiotic measures urgently requires new therapeutic strategies. in this context, antimicrobial photodynamic therapy (apdt) may play a crucial part in the future. the aim of the present study was to compare the antibacterial efficiency of apdt using the photosensitizer safranine o with that of chlorhexidine (0.2% chx) on an ex vivo biofilm. | 2014 | 24473989 |
| antimicrobial activity of chemokine cxcl10 for dermal and oral microorganisms. | cxcl10 (ip-10) is a small 10 kda chemokine with antimicrobial activity. it is induced by ifn-γ, chemoattracts mononuclear cells, and promotes adhesion of t cells. recently, we detected cxcl10 on the surface of the skin and in the oral cavity. in the current study, we used broth microdilution and radial diffusion assays to show that cxcl10 inhibits the growth of escherichia coli, staphylococcus aureus, corynebacterium jeikeium, corynebacterium striatum, and candida albicans hmv4c, but not coryneb ... | 2014 | 25859394 |
| detection of periodontal pathogens in the patients with aortic aneurysm. | the occurrence and development of aortic aneurysm (aa) are associated with infection. some researchers have detected the dna of periodontal pathogens in aa samples in certain populations. however, it has not been done in chinese population. the objective of this study was to evaluate the prevalence of periodontal pathogens in oral tissue samples and aneurysm samples of aa patients. | 2014 | 25430459 |
| prevalence of six periodontal pathogens in subgingival samples of italian patients with chronic periodontitis. | the aim of this study was to investigate the subgingival prevalence of six periodontal pathogens in 352 italian patients with chronic periodontitis. possible correlations with clinical parameters, age, gender and smoking status were also investigated. at first visit a pooled subgingival plaque sample was obtained for each subject by using the paper-point method. the samples were processed and analysed according to a commercially available quantitative real time polymerase chain reaction assay (m ... | 2014 | 25387289 |
| effect of non-surgical periodontal treatment on short chain fatty acid levels in gingival crevicular fluid of patients with generalized aggressive periodontitis. | short chain fatty acids (scfas) play important roles in periodontal diseases. however, the concentrations of scfas in gingival crevicular fluid of patients with aggressive periodontitis are not known. the aim of this intervention study was to investigate the influences of non-surgical periodontal therapy on levels of scfas in the gingival crevicular fluid of patients with generalized aggressive periodontitis (g-agp), and analyze the concentrations of scfas in sites with or without the detected p ... | 2014 | 25340203 |
| quantitative real-time pcr combined with propidium monoazide for the selective quantification of viable periodontal pathogens in an in vitro subgingival biofilm model. | differentiation of live and dead cells is an important challenge when using molecular diagnosis for microbial identification. this is particularly relevant when bacteria have been exposed to antimicrobial agents. the objective of this study was to test a method using quantitative real-time polymerase chain reaction (qpcr) combined with propidium monoazide (pma), developed for the selective quantification of viable p. gingivalis, a. actinomycetemcomitans, f. nucleatum and total bacteria in an in ... | 2014 | 23581569 |
| distinct polymicrobial populations in a chronic foot ulcer with implications for diagnostics and anti-infective therapy. | polymicrobial infections caused by combinations of different bacteria are being detected with an increasing frequency. the evidence of such complex infections is being revealed through the use of novel molecular and culture-independent methods. considerable progress has been made in the last decade regarding the diagnostic application of such molecular techniques. in particular, 16s rdna-based sequencing and even metagenomic analyses have been successfully used to study the microbial diversity i ... | 2014 | 24679105 |
| bacterial pathogens related to chronic suppurative otitis media in individuals with cleft palate: bacteriological culture and polymerase chain reaction. | to characterize the microbial etiology of chronic suppurative otitis media comparing the methods of classical bacteriological culture and polymerase chain reaction. | 2014 | 22594401 |
| energetics of pathogenic bacteria and opportunities for drug development. | the emergence and spread of drug-resistant pathogens and our inability to develop new antimicrobials to overcome resistance has inspired scientists to consider new targets for drug development. cellular bioenergetics is an area showing promise for the development of new antimicrobials, particularly in the discovery of new anti-tuberculosis drugs where several new compounds have entered clinical trials. in this review, we have examined the bioenergetics of various bacterial pathogens, highlightin ... | 2014 | 25476763 |
| antimicrobial and immunomodulatory properties of pgla-am1, cpf-am1, and magainin-am1: potent activity against oral pathogens. | cationic amphipathic α-helical peptides are intensively studied classes of host defence peptides (hdps). three peptides, peptide glycine-leucine-amide (pgla-am1), caerulein-precursor fragment (cpf-am1) and magainin-am1, originally isolated from norepinephrine-stimulated skin secretions of the african volcano frog xenopus amieti (pipidae), were studied for their antimicrobial and immunomodulatory activities against oral and respiratory pathogens. minimal effective concentrations (mecs), determine ... | 2014 | 25447193 |
| action of essential oils from brazilian native and exotic medicinal species on oral biofilms. | essential oils (eo) obtained from twenty medicinal and aromatic plants were evaluated for their antimicrobial activity against the oral pathogens candida albicans, fusobacterium nucleatum, porphyromonas gingivalis, streptococcus sanguis and streptococcus mitis. | 2014 | 25407737 |
| a comparative antimicrobial analysis of various root canal irrigating solutions on endodontic pathogens: an in vitro study. | evolution in understanding the poly-microbial environment of both endodontic infections and that of failed root canal treatments has been debatable over the years. the present study was designed to compare and analyze the effect of various root canal irrigation solutions on certain endodontic pathogens in vitro. | 2014 | 25095835 |
| relationship between halitosis and periodontal disease - associated oral bacteria in tongue coatings. | the objective of our study was to investigate the relationship between halitosis and oral bacteria in tongue coating (tc) and saliva samples from patients with halitosis, and to evaluate the effect of tongue cleaning on halitosis. | 2014 | 23890391 |
| validation of antibiotic efficacy on in vitro subgingival biofilms. | systemic antibiotics are often used as adjunctive treatment modalities for periodontal diseases. testing of antimicrobial efficacy can be relevant only if the bacteria are in the form of biofilms rather than the planktonic state, and at concentrations of physiologic relevance, i.e., reachable in the periodontal pocket. the aim of the present study is to test the antimicrobial efficacy of five common antibiotic schemes at physiologically relevant concentrations on a multispecies in vitro biofilm ... | 2014 | 23659420 |
| bimix antimicrobial scaffolds for regenerative endodontics. | eliminating and/or inhibiting bacterial growth within the root canal system has been shown to play a key role in the regenerative outcome. the aim of this study was to synthesize and determine in vitro both the antimicrobial effectiveness and cytocompatibility of bimix antibiotic-containing polydioxanone-based polymer scaffolds. | 2014 | 25201643 |
| the effect of sodium hypochlorite on enterococcus faecalis when grown on dentine as a single- and multi-species biofilm. | enterococcus faecalis is often involved in the aetiology of apical periodontitis after endodontic treatment. this project aimed to establish, on dentine in vitro, a multi-species biofilm containing e. faecalis, and to determine if the organism had an increased resistance to sodium hypochlorite compared with an axenic biofilm. biofilms were established on dentine discs in flow cells with either e. faecalis alone (axenic) or together with fusobacterium nucleatum and streptococcus sanguinis. follow ... | 2014 | 25195495 |
| susceptibility of methacrylate-based root canal filling to degradation by bacteria found in endodontic infections. | to present a case of endodontic failure obturated with a methacrylate-based root filling material, resilon/realseal (rs). to determine if rs is susceptible to biodegradation by endodontically relevant microbes by a method known to show rs degradation. | 2014 | 25019109 |
| an endodontic-periodontal lesion with primary periodontal disease: a case report on its bacterial profile. | the microflora in the periodontal pockets can affect the dental pulp and cause endodontic-periodontal lesions or retrograde pulpitis. here we report an endodontic-periodontal lesion together with its bacterial profile. the lesion occurred in the maxillary right first molar of a 40-year-old woman who presented at our hospital complaining of a violent toothache since the previous night. clinically, the tooth was caries-free and an electric pulp test showed it to be vital. the tooth showed signs of ... | 2014 | 24717928 |
| fusobacterium and enterobacteriaceae: important players for crc? | the gut microbiota plays an essential role in regulating intestinal homeostasis through its capacity to modulate various biological activities ranging from barrier, immunity and metabolic function. not surprisingly, microbial dysbiosis is associated with numerous intestinal disorders including inflammatory bowel diseases (ibd) and colorectal cancer (crc). in this piece, we will review recent evidence that gut microbial dysbiosis can influence intestinal disease, including colitis and crc. we wil ... | 2014 | 24972311 |
| intestinal dysbiosis: novel mechanisms by which gut microbes trigger and prevent disease. | new research has identified specific intestinal colonizing microbes that can have significant influence on health and disease. evidence is reviewed supporting an association between fusobacterium nucleatum and colon cancer and for a protective role of faecalibacterium prausnitzii in inflammatory bowel disease, of escherichia coli nissle 1917 in acute intestinal inflammation, of bifidobacterium infantis in neonatal necrotizing enterocolitis, and of akkermansia muciniphila in obesity and diabetes. ... | 2014 | 24857830 |
| dna-based adaptive immunity protect host from infection-associated periodontal bone resorption via recognition of porphyromonas gingivalis virulence component. | porphyromonas gingivalis (pg) is one of a constellation of oral organisms associated with human chronic periodontitis. while adaptive immunity to periodontal pathogen proteins has been investigated and is an important component of periodontal bone resorption, the effect of periodontal pathogen dna in eliciting systemic and mucosal antibody and modulating immune responses has not been investigated. | 2014 | 24051159 |
| infections caused by fusobacterium in children: a 14-year single-center experience. | this study aimed at reviewing our experience with infections caused by fusobacterium in children. | 2015 | 25929419 |
| hydrogen sulfide production from subgingival plaque samples. | periodontitis is a polymicrobial anaerobe infection. little is known about the dysbiotic microbiota and the role of bacterial metabolites in the disease process. it is suggested that the production of certain waste products in the proteolytic metabolism may work as markers for disease severity. hydrogen sulfide (h2s) is a gas produced by degradation of proteins in the subgingival pocket. it is highly toxic and believed to have pro-inflammatory properties. we aimed to study h2s production from su ... | 2015 | 25280920 |
| peripheral blood neutrophil cytokine hyper-reactivity in chronic periodontitis. | pro-inflammatory cytokine release (il-8, il-6, tnf-α, il-1β) by peripheral blood neutrophils, isolated from periodontitis patients (before/after therapy) and matched controls, was determined after 18 h culture in the presence/absence of escherichia coli lps, opsonised staphylococcus aureus, heat-killed fusobacterium nucleatum and porphyromonas gingivalis. all cultures demonstrated differences in the amounts of each cytokine detected (p < 0.0001), with a clear release pattern (il-8 > il-6 > tnf-α ... | 2015 | 26055820 |
| fusobacterium and escherichia: models of colorectal cancer driven by microbiota and the utility of microbiota in colorectal cancer screening. | intestinal microbiota has emerging roles in the development of colorectal cancer (crc). intestinal dysbiosis, with altered levels of specific bacteria, is consistently seen in crc. the heart of the debate lies in whether these bacteria are a cause or consequence of crc. two bacteria in particular, fusobacterium nucleatum and escherichia coli, have consistently been associated with crc. this review will examine evidence supporting oncogenic roles of f. nucleatum and e. coli. the proposed mechanis ... | 2015 | 25582922 |
| hierarchical micro/nanostructured titanium with balanced actions to bacterial and mammalian cells for dental implants. | a versatile strategy to endow dental implants with long-term antibacterial ability without compromising the cytocompatibility is highly desirable to combat implant-related infection. silver nanoparticles (ag nps) have been utilized as a highly effective and broad-spectrum antibacterial agent for surface modification of biomedical devices. however, the high mobility and subsequent hazardous effects of the particles on mammalian cells may limit its practical applications. thus, ag nps were immobil ... | 2015 | 26604743 |
| subgingival plaque in periodontal health antagonizes at toll-like receptor 4 and inhibits e-selectin expression on endothelial cells. | the ability of the subgingival microbial community to induce an inappropriate inflammatory response ultimately results in the destruction of bone and gingival tissue. in this study, subgingival plaque samples from both healthy and diseased sites in the same individual were obtained from adults with chronic periodontitis and screened for their ability to either activate toll-like receptor 2 (tlr2) or tlr4 and to antagonize tlr4-specific activation by agonist, fusobacterium nucleatum lps. subgingi ... | 2015 | 26483407 |
| antimicrobial effectiveness of cetylpyridinium chloride and zinc chloride-containing mouthrinses on bacteria of halitosis and peri-implant disease. | to clarify the antimicrobial efficacy of zinc chloride (zncl2) and cetylpyridinium chloride (cpc) by testing their impact on the growth of seven bacterial strains known to be involved in the pathophysiology of both peri-implant disease and halitosis-staphylococcus aureus, streptococcus mutans, porphyromonas gingivalis, prevotella intermedia, fusobacterium nucleatum, treponema denticola, and tannerella forsythia. | 2015 | 26478974 |
| lethal effect of blue light-activated hydrogen peroxide, curcumin and erythrosine as potential oral photosensitizers on the viability of porphyromonas gingivalis and fusobacterium nucleatum. | recently, photodynamic therapy (pdt) has been introduced as a new modality in oral bacterial decontamination. current research aims to evaluate the effect of photodynamic killing of visible blue light in the presence of hydrogen peroxide, curcumin and erythrosine as potential oral photosensitizers on porphyromonas gingivalis associated with periodontal bone loss and fusobacterium nucleatum associated with soft tissue inflammation. | 2015 | 26246690 |
| inactivating effects of the lactoperoxidase system on bacterial lyases involved in oral malodour production. | the main components of oral malodour have been identified as volatile sulfur compounds (vscs), including hydrogen sulfide (h(2)s) and methyl mercaptan (ch(3)sh). the lactoperoxidase (lpo) system (consisting of lpo, glucose oxidase, glucose and thiocyanate) was previously shown to exhibit antimicrobial activities against some oral bacteria in vitro and suppressive effects on vscs in mouth air in a clinical trial. here, we examined the in vitro effects of the lpo system on the activities of the ba ... | 2015 | 26242770 |
| efficacy of a novel antimicrobial peptide against periodontal pathogens in both planktonic and polymicrobial biofilm states. | streptococcus gordonii, fusobacterium nucleatum and porphyromonas gingivalis represent the early, middle and late colonizers of the bacterial accretion in dental plaque biofilms. these sessile communities constitute a protected mode of growth that promotes survival in a hostile environment. this study describes a novel and unrecognized role for a synthetic cationic antimicrobial peptide, nal-p-113, which inhibits and kills periodontal bacteria in planktonic state, inhibits the formation of biofi ... | 2015 | 26210284 |
| wild blueberry (vaccinium angustifolium ait.) polyphenols target fusobacterium nucleatum and the host inflammatory response: potential innovative molecules for treating periodontal diseases. | blueberries contain significant amounts of flavonoids to which a number of beneficial health effects in humans have been associated. the present study investigated the effect of a polyphenol-rich lowbush blueberry (vaccinium angustifolium ait.) extract on the two main etiologic components of periodontitis, a multifactorial disorder affecting the supporting structures of the teeth. phenolic acids, flavonoids (flavonols, anthocyanins, flavan-3-ols), and procyanidins made up 16.6, 12.9, and 2.7% of ... | 2015 | 26207764 |
| fusobacterium nucleatum and t cells in colorectal carcinoma. | evidence indicates a complex link between gut microbiome, immunity, and intestinal tumorigenesis. to target the microbiota and immunity for colorectal cancer prevention and therapy, a better understanding of the relationship between microorganisms and immune cells in the tumor microenvironment is needed. experimental evidence suggests that fusobacterium nucleatum may promote colonic neoplasia development by downregulating antitumor t cell-mediated adaptive immunity. | 2015 | 26181352 |
| periodontal pathogens porphyromonas gingivalis and fusobacterium nucleatum promote tumor progression in an oral-specific chemical carcinogenesis model. | oral squamous cell carcinoma (oscc) is a lethal disease whose incidence is increasing. epidemiologic studies demonstrate an association between periodontitis and oral cancer, and periodontal pathogens are implicated in the pathogenesis of numerous disorders, including rheumatoid arthritis, cardiovascular diseases, diabetes and gastrointestinal malignancies. nevertheless, a causal role for periodontal pathogens in oscc has not been shown, partly due to the lack of an appropriate animal model. her ... | 2015 | 26158901 |
| influence of the prosthetic index into morse taper implants on bacterial microleakage. | to evaluate the influence of morse taper implant index on microleakage. | 2015 | 26068320 |
| mechanistic analysis of plga/hpmc-based in-situ forming implants for periodontitis treatment. | in-situ forming implant formulations based on poly(lactic-co-glycolic acid) (plga), acetyltributyl citrate (atbc), minocycline hcl, n-methyl pyrrolidone (nmp) and optionally hydroxypropyl methylcellulose (hpmc) were prepared and thoroughly characterized in vitro. this includes electron paramagnetic resonance (epr), nuclear magnetic resonance ((1)h nmr), mass change and drug release measurements under different conditions, optical microscopy, size exclusion chromatography (sec) as well as antibac ... | 2015 | 26047797 |
| [a case of corticosteroid-responsive lemierre syndrome with clivus osteomyelitis and a mass in the cavernous sinus-suprasellar region]. | lemierre syndrome is a clinical syndrome that presents with internal jugular thrombophlebitis, septicemia and systemic abscess formations. in general, the condition is preceded by oropharyngeal infections. we report a case of a 73-year-old man with lemierre syndrome, clivus osteomyelitis and a steroid-responsive mass in the cavernous sinus-suprasellar region. he complained of fever, occipital pain, diplopia and right ptosis. administration of oral steroids ameliorated the ophthalmic symptoms for ... | 2015 | 26028195 |
| [spondylodiscitis due to fusobacterium nucleatum: new diagnostic method]. | fusobacterium spp. are gram negative anaerobe bacteria. vertebral osteomyelitis caused by these bacteria is very unusual; in fact, we could only find 11 cases in the literature. we report the case of a male, 46 year-old patient who had had lumbar pain for several weeks that irradiated to the right leg, and did not respond to nsaid treatment. the work-up included mri, biopsy with draining of the collection and a universal pcr followed by 16s rdna sequencing. the latter was used to make the microb ... | 2015 | 26021107 |
| a clinical study evaluating changes in the microbial flora around dental implants during various stages of implant restoration. | this study evaluated the microbial colonization of dental implants in healthy patients before placing the implants and during the various stages of implant treatment. | 2015 | 25996787 |
| real-time monitoring of the metabolic activity of periodontopathic bacteria. | bacterial metabolic activity is associated with the onset and progression mechanisms of oral biofilm-mediated disease; however, at present no method to monitor bacterial metabolism exists, especially for periodontopathic bacteria. therefore, we aimed to establish a novel method for monitoring the metabolic activity of periodontopathic bacteria, porphyromonas gingivalis (pg), prevotella intermedia (pi) and fusobacterium nucleatum (fn), as well as streptococcus mutans (sm) for comparison. the meth ... | 2015 | 25986950 |
| liquid based microbiological transport systems: conformity assessment of two commercial devices. | we compared two types of liquid-based microbiology devices for microorganism viability according to standardized quantitative elution method clsi m40-a2. the eswab® met clsi acceptance criteria of viability maintenance for all microorganisms tested. the σ-transwab® failed to meet clsi acceptance criteria for peptostreptococcus anaerobius, prevotella melaninogenica, fusobacterium nucleatum and haemophilus influenzae. | 2015 | 25957512 |
| internal jugular vein septic thrombophlebitis (lemierre syndrome) as a complication of pharyngitis. | sore throat is a common presenting complaint in the outpatient setting. most cases are nonbacterial in origin, but those that are bacterial are usually the result of group a β-hemolytic streptococcus. guidelines exist to help physicians decide whether to treat with an antibiotic. lemierre syndrome is a dangerous potential sequela of pharyngitis that results in septic thrombophlebitis of the internal jugular (ij) vein. a high index of suspicion is needed to consider this diagnosis in the workup o ... | 2015 | 25957375 |
| pyrosequencing analysis of subgingival microbiota in distinct periodontal conditions. | subgingival microorganisms are potentially associated with periodontal diseases. however, changes in the subgingival microbiota during the progress of periodontal diseases are poorly understood. in this study, we analyzed bacterial communities in the subgingival paper point samples from 32 korean individuals with no sign of disease, gingivitis, or periodontitis using 454 flx titanium pyrosequencing. a total of 256,113 reads representing 26 phyla, 433 genera, and 1,016 species were detected. bact ... | 2015 | 25904141 |
| pyogenic liver abscess caused by fusobacterium in a 21-year-old immunocompetent male. | a 21-year-old male with no significant past medical history, presented with right upper quadrant (ruq) abdominal pain along with fevers and chills. lab work revealed leukocytosis, anemia, and slightly elevated alkaline phosphatase. viral serology for hepatitis b virus, hepatitis c virus, and human immunodeficiency virus were negative and he was immunocompetent. computed tomography imaging revealed hepatic abscesses, the largest measuring 9.5 cm. empiric antibiotics were started and percutaneous ... | 2015 | 25834342 |
| short-chain fatty acids in infected root canals of teeth with apical periodontitis before and after treatment. | short-chain fatty acids (scfas) are bacterial metabolic end products that may function as virulence factors. this study evaluated the occurrence of scfas in infected root canals before and after treatment. | 2015 | 25799538 |
| the effect of blue light on periodontal biofilm growth in vitro. | we have previously shown that blue light eliminates the black-pigmented oral bacteria porphyromonas gingivalis, prevotella intermedia, prevotella nigrescens, and prevotella melaninogenica. in the present study, the in vitro photosensitivity of the above black-pigmented microorganisms and four fusobacteria species (fusobacterium nucleatum ss. nucleatum, f. nucleatum ss. vincentii, f. nucleatum ss. polymorphum, fusobacterium periodonticum) was investigated in pure cultures and human dental plaque ... | 2015 | 25759232 |
| subacute osteomyelitis of the femur due to fusobacterium nucleatum in a 7-year-old boy. | subacute hematogenous osteomyelitis is an insidious infection, which commonly has a delayed diagnosis. we describe the case of a 7-year-old boy with subacute osteomyelitis, which was initially considered to be a bone tumor. infection should be considered in all cases of bone pain, especially in children, even in the absence of typical systemic features of inflammation. | 2015 | 25742081 |
| dna methylation differentially regulates cytokine secretion in gingival epithelia in response to bacterial challenges. | epigenetic modifications are changes in gene expression without altering dna sequence. we previously reported that bacteria-specific innate immune responses are regulated by epigenetic modifications. our hypothesis is that dna methylation affects gingival cytokine secretion in response to bacterial stimulation. gingival epithelial cells (gecs) were treated with dnmt-1 inhibitors prior to porphyromonas gingivalis (pg) or fusobacterium nucleatum (fn) exposure. protein secretion was assessed using ... | 2015 | 25722484 |
| oral bacteria adherence to suture threads: an in vitro study. | this study investigated the adherence of oral microorganisms to different types of suture threads. | 2015 | 25711725 |
| high in vitro antibacterial activity of pac-525 against porphyromonas gingivalis biofilms cultured on titanium. | in order to investigate the potential of short antimicrobial peptides (amps) as alternative antibacterial agents during the treatment of peri-implantitis, the cytotoxic activity of three short amps, that is, pac-525, ksl-w, and ksl, was determined using the mtt assay. the antimicrobial activity of these amps, ranging in concentration from 0.0039 mg/ml to 0.5 mg/ml, against the predominant planktonic pathogens, including streptococcus sanguis, fusobacterium nucleatum, and porphyromonas gingivalis ... | 2015 | 25710035 |
| killing dental pathogens using antibacterial graphene oxide. | dental caries and periodontal diseases have a close relationship with microbes such as streptococcus mutans, porphyromonas gingivalis and fusobacterium nucleatum. graphene oxide (go), as the derivative of graphene, plays an important role in many areas including biology and medicine. in particular, it has been known as a promising antimicrobial nanomaterial. in this study, we focused on the antimicrobial property of go against dental pathogens. with the utilization of 3-(4,5-dimethylthiazol-2-yl ... | 2015 | 25705785 |
| advanced caries microbiota in teeth with irreversible pulpitis. | bacterial taxa in the forefront of caries biofilms are candidate pathogens for irreversible pulpitis and are possibly the first ones to invade the pulp and initiate endodontic infection. this study examined the microbiota of the most advanced layers of dentinal caries in teeth with irreversible pulpitis. | 2015 | 26187422 |
| isolation of alkaline-tolerant bacteria from primary infected root canals. | alkaline-tolerant bacteria in primary infected root canals could have enhanced survival capacity against antimicrobials commonly used in root canal treatment. the aims of this study were to isolate and characterize alkaline-tolerant bacteria before endodontic treatment (s1), after chemomechanical root canal preparation (s2), and after calcium hydroxide dressing (s3). | 2015 | 25638530 |
| in vitro growth-inhibitory effect of ethanol gras plant and supercritical co₂ hop extracts on planktonic cultures of oral pathogenic microorganisms. | conventional chemical antiseptics used for treatment of oral infections often produce side-effects, which restrict their long-term use. plants are considered as perspective sources of novel natural antiseptics. however, little is still known about their inhibitory properties against oral pathogens. the objective of this study was to test in vitro antimicrobial activities of generally recognized as safe (gras) species against planktonic cultures of cariogenic, periodontal and candidal microorgani ... | 2015 | 26232134 |
| cellular components mediating coadherence of candida albicans and fusobacterium nucleatum. | candida albicans is an opportunistic fungal pathogen found as part of the normal oral flora. it can be coisolated with fusobacterium nucleatum, an opportunistic bacterial pathogen, from oral disease sites, such as those involved in refractory periodontitis and pulp necrosis. the physical coadherence between these 2 clinically important microbes has been well documented and suggested to play a role in facilitating their oral colonization and colocalization and contributing to polymicrobial pathog ... | 2015 | 26152186 |
| microflora in oral ecosystems and salivary secretion rates--a 3-year follow-up after radiation therapy to the head and neck region. | results indicate that late improvements of radiation therapy (rt) in the head and neck region may diminish the long-term effects on salivary glands and oral microflora. the aim was therefore to analyze salivary secretion rates and oral microflora over time in rt subjects. | 2015 | 26058004 |
| microbial community in persistent apical periodontitis: a 16s rrna gene clone library analysis. | to characterize the microbial composition of persistent periapical lesions of root filled teeth using a molecular genetics approach. | 2015 | 25088120 |
| microbiological profile resistant to different intracanal medications in primary endodontic infections. | this clinical study aimed to determine the microbiological profile resistant to different intracanal medications in primary endodontic infections by using both microbiological culture and the checkerboard dna-dna hybridization technique. | 2015 | 25892513 |
| phototargeting human periodontal pathogens in vivo. | the effects of blue light at 455 nm were investigated on the bacterial composition of human dental plaque in vivo. eleven subjects who refrained from brushing for 3 days before and during phototherapy participated in the study. light with a power density of 70 mw/cm(2) was applied to the buccal surfaces of premolar and molar teeth on one side of the mouth twice daily for 2 min over a period of 4 days. dental plaque was harvested at baseline and again at the end of 4 days from eight posterior tee ... | 2015 | 24346334 |
| subgingival microbiome in smokers and non-smokers in korean chronic periodontitis patients. | smoking is a major environmental factor associated with periodontal diseases. however, we still have a very limited understanding of the relationship between smoking and subgingival microflora in the global population. here, we investigated the composition of subgingival bacterial communities from the pooled plaque samples of smokers and non-smokers, 134 samples in each group, in korean patients with moderate chronic periodontitis using 16s rrna gene-based pyrosequencing. a total of 17,927 reads ... | 2015 | 25283067 |
| influence of biofilm formation by gardnerella vaginalis and other anaerobes on bacterial vaginosis. | bacterial vaginosis (bv) is the worldwide leading vaginal disorder among women of reproductive age. bv is characterized by the replacement of beneficial lactobacilli and the augmentation of anaerobic bacteria. gardnerella vaginalis is a predominant bacterial species, but bv is also associated with other numerous anaerobes, such as atopobium vaginae, mobiluncus mulieris, prevotella bivia, fusobacterium nucleatum, and peptoniphilus species. currently, the role of g. vaginalis in the etiology of bv ... | 2015 | 26080369 |
| [noma/cancrum oris: a neglected disease]. | noma is an aggressive orofacial gangrenous pathology that damages hard and soft tissues of the mouth and the face. throughout the centuries it has been present around the globe, but nowadays it has practically disappeared from developed countries and mainly affects children from the most disadvantaged places, especially in africa. noma disease is a multifactorial process; malnutrition, debilitating diseases (bacterial or viral systemic diseases, hiv-associated immunosuppression, etc.) and intrao ... | 2015 | 26437752 |
| identification of an antibacterial protein by functional screening of a human oral metagenomic library. | screening of a bacterial artificial chromosome (bac) library containing metagenomic dna from human plaque and saliva allowed the isolation of four clones producing antimicrobial activity. three of these were pigmented and encoded homologues of glutamyl-trna reductase (glutr), an enzyme involved in the c5 pathway leading to tetrapyrole synthesis, and one clone had antibacterial activity with no pigmentation. the latter contained a bac with an insert of 15.6 kb. initial attempts to localize the ge ... | 2015 | 26347298 |
| randomized in vivo evaluation of photodynamic antimicrobial chemotherapy on deciduous carious dentin. | the aim of this randomized in vivo study was to compare antimicrobial chemotherapies in primary carious dentin. thirty-two participants ages 5 to 7 years underwent partial caries removal from deep carious dentin lesions in primary molars and were subsequently divided into three groups: control [chlorhexidine and resin-modified glass ionomer cement (rmgic)], ledtb [photodynamic antimicrobial chemotherapy (pact) with light-emitting diode associated with toluidine blue solution and rmgic], and lmb ... | 2015 | 26502235 |
| effect of bdellovibrio bacteriovorus hd100 on multispecies oral communities. | the predation of bdellovibrio bacteriovorus on different periodontal pathogens has already been described. however, it is necessary to consider the polymicrobial nature of periodontal disease. the current study explores the predation of bdellovibrio on oral pathogens organized in multispecies communities. the effect of the predator was evaluated on in vitro six species communities with microbial culturing. additionally, the effect on ex vivo subgingival plaque and saliva samples from periodontit ... | 2015 | 25252124 |
| real-time pcr quantification of six periodontal pathogens in saliva samples from healthy young adults. | the use of saliva as a diagnostic fluid for the evaluation of periodontal health has gained attention recently. most published real-time pcr assays focused on quantification of bacteria in subgingival plaque, not in saliva. the aims of this study were to develop a real-time pcr assay for quantification of six periodontal pathogens in saliva and to establish a relationship between the amount of dna (fg) and colony-forming unit (cfu). | 2015 | 25217278 |
| essential oils and isolated compounds from lippia alba leaves and flowers: antimicrobial activity and osteoclast apoptosis. | in the present study, essential oils extracted from the leaves and flowers of lippia alba (mill.) n.e.br. (l. alba) were analyzed for their antimicrobial activity and their effects on osteoclasts. the periodontal pathogens, aggregatibacter actinomycetemcomitans (a. actinomycetemcomitans; atcc 43717), fusobacterium nucleatum (f. nucleatum; atcc 25586) and porphyromonas gingivalis (p. gingivalis); atcc 33277) were used in antimicrobial activity assays for determining the minimum inhibitory concent ... | 2015 | 25384405 |
| antimicrobial activity of platelet-rich plasma and other plasma preparations against periodontal pathogens. | in addition to releasing a pool of growth factors during activation, platelets have many features that indicate their role in the anti-infective host defense. the antimicrobial activities of platelet-rich plasma (prp) and related plasma preparations against periodontal disease-associated bacteria were evaluated. | 2015 | 25345340 |
| alcohol consumption and periodontitis: quantification of periodontal pathogens and cytokines. | there are few studies on periodontal status related to microbiologic and immunologic profiles among individuals not or occasionally using alcohol and those with alcohol dependence. the aim of this study is to determine the effect of alcohol consumption on the levels of subgingival periodontal pathogens and proinflammatory cytokines (interleukin [il]-1β and tumor necrosis factor [tnf]-α) in the gingival fluid among individuals with and without periodontitis. | 2015 | 26062839 |
| quantitation of biofilm and planktonic life forms of coexisting periodontal species. | complexity of oral polymicrobial communities has prompted a need for developing in vitro models to study behavior of coexisting bacteria. little knowledge is available of in vitro co-growth of several periodontitis-associated species without early colonizers of dental plaque. | 2015 | 25926392 |
| occurrence of periodontal pathogens in ethnic groups from a native brazilian reservation. | the present study was designed to evaluate the occurrence of periodontal pathogens in the subgingival biofilm of 100 native brazilians living at the umutina indian reservation, mato grosso state, brazil. | 2015 | 25847068 |
| antibacterial photodynamic treatment of periodontopathogenic bacteria with indocyanine green and near-infrared laser light enhanced by trolox(tm). | it has been shown that certain vitamins can significantly enhance the effect of photodynamic anti-tumor therapy. unfortunately, there is no sufficient information available about the impact of those antioxidants on antimicrobial photodynamic therapy (apdt). the present study is aimed at investigating the antimicrobial effect of the dye indocyanine green (icg) in the presence of trolox(tm) , a vitamin e analogue, upon irradiation with near-infrared (nir) laser light (808 nm) on the gramnegative p ... | 2015 | 25753989 |
| anti-inflammatory, antioxidant and antimicrobial effects of artemisinin extracts from artemisia annua l. | the anti-inflammatory, antioxidant, and antimicrobial properties of artemisinin derived from water, methanol, ethanol, or acetone extracts of artemisia annua l. were evaluated. all 4 artemisinin-containing extracts had anti-inflammatory effects. of these, the acetone extract had the greatest inhibitory effect on lipopolysaccharide-induced nitric oxide (no), prostaglandin e2 (pge2), and proinflammatory cytokine (il-1β , il-6, and il-10) production. antioxidant activity evaluations revealed that t ... | 2015 | 25605993 |