Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| stat1 gene expression in cervical carcinomas. | expression of the stat1 gene belonging to the group of interferon-regulated genes was analyzed in cervical tumors and cell lines harboring the genome of human papilloma viruses (hpv) of so-called high risk group. expression of this gene in invasive carcinomas was maintained on a definite level that was not significantly distinct from that in adjacent normal (control) tissue. tumors from different patients differ from each other by expression level of the stat1 gene. these variations can be attri ... | 2007 | 17680769 |
| colposcopy is not necessary to assess the risk to the cervix in hiv-positive women: an international cohort study of cervical pathology in hiv-1 positive women. | the objectives of this prospective multicentre international cohort study are to describe the characteristics of a cohort of hiv-1 positive women and determine the best management system by comparing cervical pathology according to results of cytology, colposcopy and human papillomavirus (hpv) testing at baseline and throughout follow-up. a. cohorts of known hiv-positive women were recruited from 6 hospital-based european centres and a community-based south african centre. following registration ... | 2007 | 17683070 |
| [transcriptional inhibition of human papilloma virus in cervical carcinoma cells reactivates functions of the tumor suppressor p53]. | inactivation of tumor suppressor p53 accompanies the majority of malignant diseases in humans. restoration of p53 functions in tumor results in death of cancer cells, which can be used in cancer therapy. in cervical cancer a product of e6 gene of the human papilloma virus promotes accelerated degradation of p53 in proteasome system. therefore, one of the approaches to reactivation of p53 in cervical carcinoma cells could be the use of small molecules that inhibit functions of viral proteins. by ... | 2007 | 17685229 |
| retinoic acid receptor beta silences human papillomavirus-18 oncogene expression by induction of de novo methylation and heterochromatinization of the viral control region. | retinoic acid receptor beta2 (rar beta2) is often down-regulated during the multistep process to cervical cancer. in that way, its inhibitory function on the transcription factor ap-1, indispensable to maintain human papillomavirus (hpv) gene expression is relieved. using hpv-18 positive hela cells as a model system, we show that ectopic expression of rar beta2 is able to down-regulate hpv-18 transcription by selectively abrogating the binding of ap-1 to the viral regulatory region in a ligand-i ... | 2007 | 17686773 |
| inhibition of transfer to secondary receptors by heparan sulfate-binding drug or antibody induces noninfectious uptake of human papillomavirus. | infection with various human papillomaviruses (hpvs) induces cervical cancers. cell surface heparan sulfates (hs) have been shown to serve as primary attachment receptors, and molecules with structural similarity to cell surface hs, like heparin, function as competitive inhibitors of hpv infection. here we demonstrate that the n,n'-bisheteryl derivative of dispirotripiperazine, dstp27, efficiently blocks papillomavirus infection by binding to hs moieties, with 50% inhibitory doses of up to 0.4 m ... | 2007 | 17686860 |
| multiple copies of a tumor epitope in a recombinant hepatitis b surface antigen (hbsag) vaccine enhance ctl responses, but not tumor protection. | we propose the replacement of endogenous epitopes with foreign epitopes to exploit the highly immunogenic hepatitis b surface antigen (hbsag) as a vaccine vector to elicit disease-protective cytotoxic t-lymphocyte (ctl) responses. locations were defined within the hbsag gene where replacements of dna encoding hbsag epitopes may be made to generate functional recombinant (r) hbsag dna vaccines. we demonstrate that rhbsag dna vaccines encoding multiple copies of a model tumor epitope from human pa ... | 2007 | 17689584 |
| therapeutic value of trichloroacetic acid in the treatment of isolated genital warts on the external female genitalia. | to evaluate the value of 85% trichloroacetic acid (tca) in the treatment of human papillomavirus (hpv)-associated genital warts of the external genitalia and to detect the recurrence rate and side effects of this therapeutic regimen. | 2007 | 17694970 |
| effect of human papillomavirus 16/18 l1 viruslike particle vaccine among young women with preexisting infection: a randomized trial. | viruslike particle human papillomavirus (hpv) vaccines were designed to prevent hpv infection and development of cervical precancers and cancer. women with oncogenic hpv infections might consider vaccination as therapy. | 2007 | 17699008 |
| detection of human papillomavirus genotypes 16/18/45 by hybrid capture hybridisation genotyping probe in clinical specimens: the first report. | 2007 | 17702646 | |
| profile of viral load, integration, and e2 gene disruption of hpv58 in normal cervix and cervical neoplasia. | the clinical utility of viral-load and integration status of human papillomavirus (hpv) infection remains uncertain. we examined 75 women infected with hpv58, a worldwide rare type found to be prevalent in cervical cancers in eastern asia. viral load was significantly higher for cervical intraepithelial neoplasia (cin) 1/2, but those for a normal control group and for cin 3 or cancer overlapped substantially. a pure integrated genome was found for all lesion grades, giving a poor positive predic ... | 2007 | 17703417 |
| the impact of hiv status and type on the clearance of human papillomavirus infection among senegalese women. | persistent infection with human papillomavirus (hpv) is associated with the development and progression of hpv-related disease, including cervical intraepithelial neoplasia (cin) and invasive cervical cancer. | 2007 | 17703420 |
| role of human papillomavirus genotype in prognosis of early-stage cervical cancer undergoing primary surgery. | our aim was to evaluate the prognostic significance of human papillomavirus (hpv) genotype in early-stage cervical carcinoma primarily treated with surgery in a large tertiary referral medical center. | 2007 | 17704412 |
| do g protein-coupled receptors expressed in human lingual epithelium interact with hpv11? | human papillomaviruses infect epithelia but little is known about the nature of cell surface receptors interacting with the viral particles. it has been proposed that glycosaminoglycans and integrins may be involved in the attachment process. in the present study, the putative interactions of virus-like particles of human papillomavirus type 11 (hpv11), which present a tropism for nasopharyngeal epithelia, with olfactory and taste receptors expressed in the human lingual epithelium were studied. ... | 2007 | 17705193 |
| viral load of episomal and integrated forms of human papillomavirus type 33 in high-grade squamous intraepithelial lesions of the uterine cervix. | the association between total and integrated hpv-33 dna loads and high-grade squamous intraepithelial lesions (hsil) of the uterine cervix was investigated. of 5,347 women recruited in 4 studies, 89 (64 without sil, 7 low-grade sil (lsil), 15 hsil, 3 unknown grade) were infected by hpv-33. hpv-33 e6, hpv-33 e2 and beta-globin dna were measured with real-time pcr that allowed to assess total (e6), episomal (e2) and integrated (e6-e2) hpv-33 viral loads. hpv-33 e6/e2 ratios >/=>/=2.0 suggesting th ... | 2007 | 17708553 |
| b subunit of shiga toxin-based vaccines synergize with alpha-galactosylceramide to break tolerance against self antigen and elicit antiviral immunity. | the nontoxic b subunit of shiga toxin (stxb) targets in vivo ag to dendritic cells that preferentially express the glycolipid gb(3) receptor. after administration of stxb chemically coupled to ova (stxb-ova) or e7, a polypeptide derived from hpv, in mice, we showed that the addition of alpha-galactosylceramide (alpha-galcer) resulted in a dramatic improvement of the stxb ag delivery system, as reflected by the more powerful and longer lasting cd8(+) t cell response observed even at very low dose ... | 2007 | 17709554 |
| the human papillomavirus vaccine and its relevance in israel. | 2007 | 17710788 | |
| urine versus brushed samples in human papillomavirus screening: study in both genders. | to investigate whether urine is a good medium for screening and whether there is a correlation between the amount of extracted dna and human papillomavirus (hpv)-positivity. | 2007 | 17712490 |
| recurrence in patients with oral and oropharyngeal squamous cell carcinoma: human papillomavirus and other risk factors. | the results confirm that tumour stage influences the risk of recurrence/second primary tumour (spt). high-risk human papillomavirus (hpv)-infected patients have a significantly higher risk of recurrence/spt compared with high-risk hpv-negative patients. high alcohol consumption was associated with a higher risk of recurrence/spt. in this study, the competing risk of death in intercurrent disease (dicd) was given special consideration. | 2007 | 17712679 |
| age at first intercourse and hpv immunization. | the licence of the first human papillomavirus vaccine (hpv) has important implications for the most appropriate age for a mandatory immunization. in this paper data taken from a recent study show that more than 10% of the italian women report having already had a sexual intercourse by the age of 15. there is thus sufficient evidence to recommend administration of the hpv vaccine to all girls by the age of 12. | 2007 | 17713135 |
| high-risk cervical epithelial neoplasia grade 1 treated by loop electrosurgical excision: follow-up and value of hpv testing. | this study was undertaken to evaluate the value of high-risk human papillomavirus (hpv) testing in the follow-up of cervical intraepithelial neoplasia grade 1/low-grade squamous intraepithelial lesion treated by loop electrosurgical excision procedure because of the risk criteria established by the american society for colposcopy and cervical pathology (ie, unsatisfactory colposcopy or positive endocervical curettage, persistence of cervical intraepithelial neoplasia grade 1/low-grade squamous i ... | 2007 | 17714678 |
| politics and power plays behind the hpv vaccine. an effective vaccine is mired in controversy by mandates. | 2007 | 17667381 | |
| recent advances in the search for antiviral agents against human papillomaviruses. | infection by human papillomavirus (hpv) is extremely common and associated with the development of benign warts or malignant lesions of the skin and mucosa. infection by a high-risk (oncogenic) anogenital hpv type, most often through sexual contacts, is the starting point of virtually all cases of cervical cancers and the majority of anal cancers. the same viral types are also increasingly being linked with a subset of head-and-neck and non-melanoma skin cancers. although prophylactic vaccines a ... | 2007 | 17668552 |
| [identification of human papilloma viruses (hpv) in inflammatory states and ear neoplasms]. | human papilloma virus has a strong relation to oropharyngeal mucosa and is considered to be responsible for a wide range of upper respiratory tract pathologies, like laryngeal papilloma. there's a hypothesis, that it plays a significant role in middle ear chronic inflammations and neoplasm's. material and methodic. the examination was carried on a group of 53 patients, 39 of which was suffering from granulation tissue chronic otitis media, 7-cholesteatomatous otitis media, 6--middle ear malignan ... | 2007 | 17668798 |
| prophylactic human papillomavirus vaccines: potential for sea change. | persistent human papillomavirus (hpv) infection is the central cause in the development of anogenital warts, precancers and cancers of uterine cervix, and a major factor in the genesis of other malignancies of the lower anogenital and upper aerodigestive tracts. the burden of disease carries very high medical, financial and psychosocial costs. the role of prophylactic hpv vaccines in reducing the burden of disease is discussed in light of the results of multiple randomized, controlled trials con ... | 2007 | 17669006 |
| the n-terminal module of hpv16 e7 is an intrinsically disordered domain that confers conformational and recognition plasticity to the oncoprotein. | the hpv16 e7 oncoprotein is an extended dimer, with a stable and cooperative fold, but that displays properties of "natively unfolded" proteins. two regions of conserved sequence are found in e7 proteins, where the n-terminus (1-40) includes the retinoblastoma tumor suppressor binding and casein kinase ii phosphorylation sites. a fragment containing the highly acidic n-terminal half shows an apparently disordered conformation by far-uv-circular dichroism (cd) at neutral ph, and its hydrodynamic ... | 2007 | 17715947 |
| human papillomavirus infection in hiv-infected persons. | rates of cervical and anal human papillomavirus (hpv) infection and abnormal cytology are high in hiv-infected women, as are rates of anal hpv infection and abnormal cytology in hiv-infected men who have sex with men (msm). available evidence indicates that the incidence of anal cancer in hiv-infected msm has increased in association with prolonged life expectancy achieved with antiretroviral therapy. routine screening for cervical neoplasia is recommended for hiv-infected women. routine screeni ... | 2007 | 17720998 |
| association of cutaneous anergy with human papillomavirus and cervical neoplasia in hiv-seropositive and seronegative women. | cutaneous anergy testing evaluates delayed type hypersensitivity responses and is, in essence, an in-vivo measure of cell-mediated immune function at an epithelial surface. this study assessed the relationship of anergy test results with cervical infection by human papillomavirus (hpv) and cervical neoplasia in hiv-seropositive and seronegative women. | 2007 | 17721101 |
| activation of akt and nuclear accumulation of wild type tp53 and mdm2 in anal squamous cell carcinoma. | human papilloma virus (hpv) infection is considered as an important aetiological factor for anal squamous cell carcinoma (ascc) but is not sufficient for tumour progression. this carcinoma is poorly understood at the molecular level. using the largest cohort of cases to date we investigated the molecular mechanisms underlying ascc development, in particular the roles of tp53, mdm2 and akt. viral infection in our cohort occurred at high frequency (73%, 94/128) with hpv16 accounting for the majori ... | 2007 | 17721920 |
| vaccination trial with hpv16 l1e7 chimeric virus-like particles in women suffering from high grade cervical intraepithelial neoplasia (cin 2/3). | persistent infection with human papillomaviruses (hpv) is a prerequisite for the development of cervical cancer. vaccination with virus-like particles (vlp) has demonstrated efficacy in prophylaxis but lacks therapeutic potential. hpv16 l1e7 chimeric virus-like particles (cvlp) consist of a carboxy-terminally truncated hpv16l1 protein fused to the amino-terminal part of the hpv16 e7 protein and self-assemble by recombinant expression of the fusion protein. the cvlp are able to induce l1- and e7- ... | 2007 | 17721997 |
| accuracy of hpv testing of vaginal smear obtained with a novel self-sampling device. | most of women diagnosed as having cervical cancer have not participated in organized cytological screening. aim. a study was conducted to evaluate the accuracy of human papilloma virus testing by self-collected vaginal samples in comparison to regular cytological screening. the agreement of hybrid capture 2 assay and polymerase chain reaction assay for detection of human papilloma virus dna in self-collected vaginal samples and clinician-obtained cervical smears was investigated. | 2007 | 17230283 |
| human papillomavirus: cause of epithelial lacrimal sac neoplasia? | epithelial tumours of the lacrimal sac are rare but important entities that may carry grave prognoses. in this study the prevalence and possible role of human papillomavirus (hpv) infection in epithelial tumours of the lacrimal sac were evaluated. | 2007 | 17362365 |
| human papillomavirus testing by self-sampling: assessment of accuracy in an unsupervised clinical setting. | to compare the performance and acceptability of unsupervised self-sampling with clinician sampling for high-risk human papillomavirus (hpv) types for the first time in a uk screening setting. | 2007 | 17362570 |
| superficial burns secondary to misuse of acetic acid solution. | topical use of acetic acid solutions is one of the treatments for human papillomavirus infections, although the disease can spontaneously resolve. over-the-counter availability of acetic acid solutions for medical use presents a potential hazard for misuse. here we present an example of accidental use. a 13-year-old boy was wounded as a result of using an acetic acid solution for cosmetic purposes. superficial burns on the left side of his face were managed with topical wound care, and minimal s ... | 2007 | 17351460 |
| six-month natural history of oral versus cervical human papillomavirus infection. | human papillomavirus (hpv) infection is etiologically associated with a subset of oral cancers, and yet, the natural history of oral hpv infection remains unexplored. the feasibility of studying oral hpv natural history was evaluated by collecting oral rinse samples on 2 occasions at a 6-month interval from 136 hiv-positive and 63 hiv-negative participants. cervical vaginal lavage samples were concurrently collected for comparison. hpv genomic dna was detected in oral and cervical samples by con ... | 2007 | 17354235 |
| risk of high-grade cervical intra-epithelial neoplasia based on cytology and high-risk hpv testing at baseline and at 6-months. | adding a test for high-risk human papillomavirus (hrhpv) to cytological screening enhances the detection of high-grade cervical intraepithelial neoplasia (>or=cin2), but data are required that enable long-term evaluation of screening. we investigated the >or=cin2 risk for women participating in population-based screening as a function of hrhpv and cytology testing results at baseline and at 6 months. we included 2,193 women aged 30-60 years participating in a population-based screening trial who ... | 2007 | 17354241 |
| dna vaccines encoding ii-padre generates potent padre-specific cd4+ t-cell immune responses and enhances vaccine potency. | it is now clear that cd4+ t cells play a crucial role in the generation of cd8+ t effector and memory t-cell immune responses. in this study, we enhanced the cd4+ t-cell immune responses in mice by constructing a dna vaccine encoding an invariant (ii) chain in which the class ii-associated ii peptide (clip) region is replaced with a cd4+ t-helper epitope, padre (ii-padre) (invariant pan hla-dr reactive epitope). c57bl/6 mice vaccinated with dna encoding ii-padre showed significantly greater padr ... | 2007 | 17356542 |
| human papillomavirus vaccine: waiting for a miracle. | 2007 | 17724313 | |
| human papillomavirus vaccines launch a new era in cervical cancer prevention. | 2007 | 17724324 | |
| evaluation of quantity and staining pattern of human papillomavirus (hpv)-infected epithelial cells in thin-layer cervical specimens using optimized hpv-card assay. | testing for human papillomavirus (hpv) is used in the triage of women with a cervical cytology of atypical squamous cells of undetermined significance (ascus). a fluorescent in situ hybridization assay was developed for the detection of hpv using the catalyzed receptor deposition technique (hpv-card). in this study, the utility of this assay was tested for the detection of hpv in liquid-based cervical cytology specimens. | 2007 | 17724679 |
| circulating human papillomavirus type 16 specific t-cells are associated with hla class i expression on tumor cells, but not related to the amount of viral oncogene transcripts. | human papillomavirus (hpv) is a necessary factor in the pathogenesis of cervical cancer. circulating hpv-specific t-cells responding to the e6 and e7 hpv proteins can be detected only in half of cervical cancer patients. potential explanations for the absence of this response are lack of sufficient amounts of antigen to activate the immune response or local immune escape mechanisms. we studied the relationship between hpv 16 e6/e7 oncogene mrna expression, human leukocyte antigen (hla) expressio ... | 2007 | 17724722 |
| a doctor talks about hpv vaccination. | 2007 | 17726760 | |
| re: "multiparameter calibration of a natural history model of cervical cancer". | 2007 | 17728268 | |
| national vaccination coverage among adolescents aged 13-17 years--united states, 2006. | before 2005, vaccines were administered during adolescence to "catch up" children with vaccinations not received at a younger age, with the exception of the tetanus and diphtheria (td) booster. however, since 2005, three new vaccines specifically for older children have been licensed and recommended in the united states: meningococcal conjugate vaccine (mcv4) for those aged 11-12 years and 15 years; tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (tdap) vaccine for those aged ... | 2007 | 17728694 |
| expression of p53 and its homolog, p73, in hpv dna positive oesophageal squamous cell carcinomas. | several studies have detected human papilloma virus (hpv) dna in squamous cell carcinoma of the oesophagus (oscc). in this study, we analysed oscc specimens from 114 patients for the presence of hpv dna, and p53 and p73 expression. hpv dna was detected in 44.7% of cases, with the low risk hpv11 occurring most frequently. p53 and p73 expression was detected in 70% and 61.4% of cases, respectively. there was no correlation between expression of p53, p73 or hpv infection and tumour grade, or betwee ... | 2007 | 17761206 |
| [analysis of demethylation-related hpv16 reactivation by dhplc-primer extension assay]. | to establish a sensitive assay to detect methylation status of the critical 7862nt cpg site related to transcription of hpv16 e6 and e7 genes. | 2007 | 17767865 |
| human papillomavirus: e6 and e7 oncogenes. | the recognition of a causal relationship between human papillomaviruses and cancer almost 30 years ago led to a rapid expansion of knowledge in the field, resulting in the description of the main mediators of hpv-induced carcinogenesis, the viral proteins e6 and e7. these oncoproteins show a remarkable pleiotropism in binding host-cell proteins, with the tumour suppressor genes p53 and prb as their major targets. these interactions induce proliferation, immortalization and malignant transformati ... | 2007 | 17768080 |
| [antisense targeting to human papillomavirus 18 e6/e7 affects the proliferation and apoptosis of human cervical carcinoma: an in vitro experiment with hela cells]. | to investigate the effect of eukaryotic fluorescent expression vector carrying antisense human papillomavirus (hpv) 18 e6/e7 on the growth and proliferation of human cervical carcinoma. | 2007 | 17803852 |
| human papillomavirus e6 regulates the cytoskeleton dynamics of keratinocytes through targeted degradation of p53. | the attachment and spreading of keratinocyte cells result from interactions between integrins and immobilized extracellular matrix molecules. human papillomavirus type 16 (hpv-16) e6 augmented the kinetics of cell spreading, while e6 genes from hpv-11 or bovine papillomavirus type 1 did not. the ability of e6 to interact with the e6ap ubiquitin ligase and target p53 degradation was required to augment cell-spreading kinetics; dominant negative p53 alleles also enhanced the kinetics of cell sprea ... | 2007 | 17804489 |
| racial and ethnic disparities in cervical cancer incidence rates in the united states, 1992-2003. | differences in cervical cancer incidence rates by race/ethnicity persist in the united states. we examined these differences by histologic type and by various patient and socioeconomic characteristics. | 2007 | 17805982 |
| combination of intratumoral injections of vaccinia virus mva expressing gm-csf and immunization with dna vaccine prolongs the survival of mice bearing hpv16 induced tumors with downregulated expression of mhc class i molecules. | downregulation of mhc class i molecules is believed to be often the cause of tumor immune escape and at the same time it is the major obstacle to t-cell based immunotherapy of tumors. in our experimental model, the c57bl/6 mice bearing tumors induced by tc-1/a9 cells characterized by expression of hpv16 oncogenes and downregulation of h-2b molecules were immunized with highly immunogenic e7ggg.gus dna vaccine expressing the fused gene of modified hpv16 e7 (e7ggg) with e.coli beta-glucuronidase ( ... | 2007 | 17822323 |
| human papillomavirus type 16 e7 oncoprotein inhibits apoptosis mediated by nuclear insulin-like growth factor-binding protein-3 by enhancing its ubiquitin/proteasome-dependent degradation. | the e7 protein encoded by the oncogenic human papillomavirus type 16 has been shown to bind and inactivate insulin-like growth factor-binding protein-3 (igfbp-3), the pro-apoptotic product of a tumour suppressor gene; however, the molecular mechanism underlying e7-induced inactivation of igfbp-3 remained uncertain. in this study, we map the igfbp-3-binding domain for e7 to the nuclear localization signal in the conserved c-terminal domain of igfbp-3. moreover, we demonstrate that both proteins i ... | 2007 | 17827406 |
| relationship between the expression of telomerase and human papillomavirus infection in invasive uterine cervical carcinoma. | telomerase activity was examined in invasive cervical carcinoma to assess whether it is activated during cervical malignant transformation and to look for its possible association with human papillomavirus (hpv) infection. histologically confirmed invasive cervical carcinomas and benign cervices were assayed for telomerase activity by using a modified telomere repeat amplification protocol (trap). the same cases were subjected to polymerase chain reaction (pcr) detection of hpv by using consensu ... | 2007 | 17828509 |
| strategic plans to promote head and neck cancer translational research within the radiation therapy oncology group: a report from the translational research program. | head and neck cancer is the fifth most common cancer in the united states, with an overall survival rate of approximately 40-50%. in an effort to improve patient outcomes, research efforts designed to maximize benefit and reduce toxicities of therapy are in progress. basic research in cancer biology has accelerated this endeavor and provided preclinical data and technology to support clinically relevant advances in early detection, prognostic and predictive biomarkers. recent completion of the h ... | 2007 | 17848300 |
| an oncolytic mutant of herpes simplex virus type-1 in which replication is governed by a promoter/enhancer of human papillomavirus type-16. | although herpes simplex virus type-1 (hsv-1) can be used as an oncolytic virus it has the undesirable side effect of neurotoxicity. to create a virus with improved specificity for oral cancer we used a fragment of human papillomavirus type-16, which is frequently found in oral and cervical cancers, but not elsewhere. the upstream regulatory region, urr16, was shown to have a high level of transcriptional activity in three of four oral cancer cell lines but low activity in three cell lines derive ... | 2007 | 17853922 |
| human papillomavirus dna detection in thinprep pap test vials is independent of cytologic sampling of the transformation zone. | sampling of the transformation zone (tz) and endocervical cells (ec) has been widely regarded as a quality indicator in cervical screening programs; however, the significance of a tz/ec sample (tz/ecs) in promoting disease detection remains a matter of controversy. because little data are available on the relationship between tz/ec sampling and hpv dna test results, we examined whether or not there is a measurable association between high-risk human papillomavirus (hrhpv) dna test results and tz ... | 2007 | 17854873 |
| a new window into the natural history of human papillomavirus infection: a view from the alts (atypical squamous cells of undetermined significance/low-grade squamous intraepithelial lesions triage study) trial. | 2007 | 17471424 | |
| high risk of human papillomavirus type 16 infections and of development of cervical squamous intraepithelial lesions in systemic lupus erythematosus patients. | to determine rates of human papillomavirus (hpv) infections, abnormal cervical smears, and squamous intraepithelial lesions (sil) among women with systemic lupus erythematosus (sle). | 2007 | 17471531 |
| [sexually transmitted disease (std)]. | 2007 | 17477146 | |
| sexually transmitted infections in preadolescent children. | pediatric nurse practitioners may be called on to conduct an assessment for sexual abuse of a young child. depending on the type of sexual contact, a decision may have to be made to obtain cultures for sexually transmitted infections (stis). recognizing the symptoms of stis in preadolescent children, along with having knowledge of the modes of transmission, diagnostics, and treatment, are part of the clinical decision. the impact of sti in preadolescent children has physical and emotional conseq ... | 2007 | 17478304 |
| cervical screening in the 21st century: the case for human papillomavirus testing of self-collected specimens. | cervical screening by pap smear involves a high rate of false negatives, necessitating frequent testing. because women do not like the sampling procedure, many avoid being screened. testing for the causative high-risk human papillomavirus (hpv) types, by pcr or other technologies, on self-collected (tampon) samples permits women to be monitored non-invasively. the high negative predictive value of hpv testing means a greater interval between tests, and thus reduces costs. hpv testing lends itsel ... | 2007 | 17484617 |
| prophylactic dna immunization against multiple papillomavirus types. | at least 15 different papillomavirus types are causatively associated with the development of tumors in humans. since the middle of 2006 a protective, virus-like particle based vaccine against the tumor-related hpv types 16 and 18 is commercially available. we investigated the possibility of applying dna vaccination to obtain protective antibody responses against multiple papillomavirus types. our data indicate that low amounts of dna were sufficient to induce neutralizing antibodies in mice alt ... | 2007 | 17485151 |
| hpv infection and the alterations of the prb pathway in oral carcinogenesis. | inactivation of the retinoblastoma (prb) pathway is a common event in oral squamous cell carcinoma particularly through the aberrant expression of the components within this pathway. this study examines the alterations of molecules within the prb pathway by looking at the presence of homozygous deletions in p16(ink4a) and the expression patterns of prb, cyclin d1 and cdk4, as well as the presence of human papillomavirus (hpv) in our samples. in our study, 5/20 samples demonstrated deletions of p ... | 2007 | 17487385 |
| nitrative and oxidative dna damage in cervical intraepithelial neoplasia associated with human papilloma virus infection. | recently, it was proposed that inflammation plays an integral role in the development of human papilloma virus (hpv)-induced cervical cancer. the present study sought to examine if 8-nitroguanine, a mutagenic nitrative dna lesion formed during inflammation, contributes to cervical carcinogenesis. we obtained biopsy specimens from 30 patients with cervical intraepithelial neoplasia (cin)1 (n = 9), cin2 (n = 10), cin3 (n = 6) and condyloma acuminatum (n = 5). we used immunohistochemistry to detect ... | 2007 | 17488337 |
| human papillomavirus therapeutic vaccines in head and neck tumors. | head and neck cancer represents one of the most challenging diseases as the mortality remains high despite advances in early diagnosis and treatment. human papillomavirus has been implicated in a third of head and neck squamous cell carcinomas and human papillomavirus type 16 is strongly associated with carcinomas arising from the oropharynx, the tonsil being the preferred infected site. novel therapeutic approaches including immunotherapy are currently under investigation. immune vaccines devel ... | 2007 | 17492938 |
| politics, parents, and prophylaxis--mandating hpv vaccination in the united states. | 2007 | 17494922 | |
| cancer prevention or parents' rights? | 2007 | 17500100 | |
| human papillomavirus detection in self-collected vaginal specimens and matched clinician-collected cervical specimens. | human papillomavirus (hpv) detection is an integral part of cervical cancer screening, and a range of specimen collection procedures are being tested. preliminary studies have found that the majority of women prefer self-collection of vaginal specimens instead of clinician-collected specimens of the cervix. the purposes of the current study were to explore the social and behavioral predictors of acceptance of self-collection of vaginal specimens among patients and to assess concordance in detect ... | 2007 | 17504376 |
| increased sensitivity of radiated murine cervical cancer tumors to e7 subunit vaccine-driven ctl-mediated killing induces synergistic anti-tumor activity. | the development of therapeutic vaccines has important implications for the treatment of cancer patients. here we investigate whether human papillomavirus (hpv) e7 subunit vaccines can enhance tumor radioresponse using an established cervical cancer animal model. radiation plus e7 subunit vaccines improved complete response, cure, and recurrence rates of tumors dramatically compared with single therapy alone. in particular, both components of the e7 subunit vaccines (e7 protein and cpg-oligodeoxy ... | 2007 | 17505485 |
| fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head/neck and cervical cancers. | human papillomaviruses (hpv) are associated with nearly all cervical cancers, 20% to 30% of head and neck cancers (hnc), and other cancers. because hncs also arise in hpv-negative patients, this type of cancer provides unique opportunities to define similarities and differences of hpv-positive versus hpv-negative cancers arising in the same tissue. here, we describe genome-wide expression profiling of 84 hncs, cervical cancers, and site-matched normal epithelial samples in which we used laser ca ... | 2007 | 17510386 |
| the human papilloma virus, the vaccines, and oral and oropharyngeal squamous cell carcinoma: what every dentist should know. | high-risk human papilloma virus (hpv) strains 16 and 18 have been shown to cause cervical cancer as well as other benign and malignant disorders. oral and oropharyngeal squamous cell carcinoma (ooscc) has been linked to high-risk hpv strains. recent developments in the field of immunology have resulted in a vaccine to treat patients with hpv against cervical cancer. the widespread use of the hpv vaccine should reduce the risk of cervical cancer and could decrease the risk of ooscc as well. this ... | 2007 | 17511372 |
| synthetic genes: a tool for identifying human papillomavirus genotypes by hybridization and polymerase chain reaction-based assays. | obtaining positive polymerase chain reaction (pcr) controls for human papillomavirus (hpv) diagnostic tests has been difficult because of prevalence variation in different geographic regions of each high-risk viral type. overlapping oligonucleotides were designed for hpv-18, hpv-31, hpv-45, and hpv-58 type-specific (ts) sequences. synthetic hpv viral genes were constructed by 2-step assembly pcr for accurately diagnosing ts hpv infection. | 2007 | 17512155 |
| pilot study of human-papilloma-virus vaccine in uganda. | 2007 | 17514798 | |
| accuracy of liquid based versus conventional cytology: overall results of new technologies for cervical cancer screening: randomised controlled trial. | to compare the accuracy of conventional cytology with liquid based cytology for primary screening of cervical cancer. | 2007 | 17517761 |
| the possible role of cell cycle regulators in multistep process of hpv-associated cervical carcinoma. | human papillomavirus (hpv) 16 and 18 are associated with cervical carcinogenesis through an interaction between hpv oncogenic proteins and cell cycle regulatory genes. however, the exact pathogenetic mechanisms are not determined yet. | 2007 | 17521451 |
| role of human papillomavirus in squamous cell metaplasia-dysplasia-carcinoma of the rectum. | primary colorectal squamous cell carcinoma (scc) and squamous dysplasia are uncommon and little is known about their pathogenesis. most have been reported in association with ulcerative colitis and other chronic disease states. although cervical and anal scc have been strongly linked to human papillomavirus (hpv) infection, the role of hpv in rectal squamous carcinoma has not been well-examined. we evaluated 3 cases of primary rectal scc for the presence of high-risk hpv by immunohistochemistry ... | 2007 | 17527081 |
| sexual health for people living with hiv. | sexual health is defined in terms of well-being, but is challenged by the social, cultural and economic realities faced by women and men with hiv. a sexual rights approach puts women and men with hiv in charge of their sexual health. accurate, accessible information to make informed choices and safe, pleasurable sexual relationships possible is best delivered through peer education and health professionals trained in empathetic approaches to sensitive issues. young people with hiv especially nee ... | 2007 | 17531749 |
| [genotyping of genital human papillomavirus by dna sequencing and luminex methods]. | to compare the specificity and sensitivity of two genotyping approaches for human papillomavirus (hpv). | 2007 | 17536264 |
| determinants of womens participation in cervical cancer screening trial, maharashtra, india. | to determine the factors associated with participation in cervical cancer screening and follow-up treatment in the context of a randomized controlled trial. the trial was initiated to evaluate the efficacy and cost effectiveness of visual inspection with acetic acid, cytological screening and testing for human papillomavirus in reducing the incidence of and mortality from cervical cancer in maharashtra, india. | 2007 | 17546307 |
| cervical cancer screening following the implementation of prophylactic human papillomavirus vaccination. | the recognition that infection with certain human papillomavirus (hpv) types is a necessary cause of cervical cancer has opened new fronts in the prevention of this disease. primary prevention is now possible via immunization with highly efficacious hpv vaccines, and secondary prevention has gained impetus with the advent of sensitive hpv-dna testing to improve traditional pap cytology screening programs. although universal vaccination of teenagers and young women is a desirable policy, cost rem ... | 2007 | 17547527 |
| promoter hypermethylation of tumor suppressor genes in urine from patients with cervical neoplasia. | we examined the feasibility of using detection of high-risk human papillomavirus (hpv) dna in combination with the presence of aberrantly methylated genes (dapk1, rarb, twist1, and cdh13) for urine-based cervical cancer screening. urine samples from 129 senegalese women, aged 35 years or older, 110 with (same day) biopsy-proven cervical neoplasia [cervical intraepithelial neoplasia grade 1 (cin-1): n = 9; cin-2-3/carcinoma in situ (cis): n = 29; invasive cervical cancer (icc): n = 72], and 19 wi ... | 2007 | 17548682 |
| cross-protection data for gardasil submitted to fda. | 2007 | 17549812 | |
| squamous cell cancer and human papillomavirus infection in oral lichen planus: case report and literature review. | 2007 | 17550459 | |
| questions over human papillomavirus vaccine in the us and australia. | 2007 | 17556447 | |
| public health, public trust and lobbying. | each year, infection with human papillomavirus (hpv) leads to millions of abnormal pap smears and thousands of cases of cervical cancer in the us. throughout the developing world, where pap smears are less common, hpv is a leading cause of cancer death among women. so when the international pharmaceutical giant merck developed a vaccine that could prevent infection with several key strains of hpv, the public health community was anxious to celebrate a major advance. but then marketing and lobbyi ... | 2007 | 17558977 |
| [preventive vaccines against human papilloma virus and cervical cancer]. | 2007 | 17565882 | |
| e7 properties of mucosal human papillomavirus types 26, 53 and 66 correlate with their intermediate risk for cervical cancer development. | epidemiological studies have demonstrated that 15 different mucosal human papillomavirus (hpv) types of the genus alpha of the hpv phylogetic tree are classified as high risk for cervical cancer development. three additional hpv types of the same genus, hpv26, 53 and 66, are classified as probable high-risk types. in this study, we have characterized the biological properties of the e7 oncoproteins from these three hpv types. all of the corresponding e7 proteins were able to associate with retin ... | 2007 | 17568647 |
| development of combined dna-based piezoelectric biosensors for the simultaneous detection and genotyping of high risk human papilloma virus strains. | human papilloma virus (hpv) is a dna virus belonging to the papovavirus family. genital hpv types have been subdivided into medium-low risk, and high-risk (hpv 16 and 18), frequently associated with cervical cancer. three dna-based piezoelectric biosensors were here developed for a quick detection and genotyping of hpv. | 2007 | 17573061 |
| p16ink4a expression decreases during imiquimod treatment of anal intraepithelial neoplasia in human immunodeficiency virus-infected men and correlates with the decline of lesional high-risk human papillomavirus dna load. | human papillomavirus (hpv)-associated anogenital cancers and their precursor lesions occur in excess in human immunodeficiency virus (hiv)-infected patients despite the initiation of highly active antiretroviral therapy. in this context, a drastically increased relative risk for anal intraepithelial neoplasia (ain) exists in hiv-infected men having sex with men (msm). in a pilot study, imiquimod, a topical immune response modifier, has been reported to be beneficial in the treatment of ain. | 2007 | 17573882 |
| langerhans cell density and high-grade vulvar intraepithelial neoplasia in women with human immunodeficiency virus infection. | decreased numbers of langerhans cells (lcs) in the cervix of human immunodeficiency virus (hiv)-infected women are believed to contribute to the progression of human papilloma virus (hpv)-related squamous intraepithelial lesions. however, this impairment of local immunity has not been well studied in the vulva. the objective of this study was to compare the s100+ lc density in high-grade vulvar intraepithelial neoplasia (vin) in hiv-positive and hiv-negative women. | 2007 | 17576336 |
| type-specific and cross-reactive antibodies induced by human papillomavirus 31 l1/l2 virus-like particles. | the aim of this study was to determine whether antibodies induced by human papillomavirus (hpv) type 31 l1/l2 virus-like particles (vlps) could cross-react with vlps of the closely related hpv-16 and distantly related hpv-11, and to investigate the potential role of the l2 protein in l1/l2 vlps in inducing cross-neutralizing antibodies. antisera were prepared from rabbits immunized with intact or denatured hpv-31 l1/l2 vlps. cross-reaction and cross-neutralization were analysed by western blotti ... | 2007 | 17577054 |
| immunohistochemical overexpression of p16 and p53 in uterine serous carcinoma and ovarian high-grade serous carcinoma. | the immunohistochemical expression pattern of p16 in biopsy samples has been useful as part of a panel to distinguish adenocarcinomas arising from the endometrium from those arising from the endocervix. however, no information is available on the expression of p16 in uterine serous carcinoma (usc) or ovarian high-grade serous carcinoma that could be used for diagnostic purposes. here, we retrospectively analyzed the immunohistochemical expression of p16 in 11 cases of usc (5 pure and 6 mixed wit ... | 2007 | 17581420 |
| human papillomavirus vaccine for genotypes 6, 11, 16 and 18: new drug. cervical cancer prevention: high hopes.... | (1) most cases of high-grade anogenital dysplasia and malignancy are caused by human papillomavirus (hpv) genotypes 16 and 18. anogenital papilloma and condyloma acuminata are mainly caused by hpv6 and hpv11. (2) a recombinant vaccine covering these four genotypes is now marketed in the european union for the prevention of condyloma, precancerous lesions, and cancers of the female lower genital tract. (3) a three-dose vaccination schedule (0, 2 and 6 months) elicits an immune response in almost ... | 2007 | 17582921 |
| combined ultrasound and magnetic resonance imaging findings on cervical verrucous carcinoma with endometrial invasion: a case report. | cervical verrucous carcinoma is a rare form of cervical cancer. very few reports present the correlation between diagnostic images and clinicopathologic findings. | 2007 | 17583251 |
| polycyclic aromatic hydrocarbon-dna adducts in cervix of women infected with carcinogenic human papillomavirus types: an immunohistochemistry study. | among women infected with carcinogenic human papillomavirus (hpv), there is a two- to five-fold increased risk of cervical precancer and cancer in women who smoke compared to those who do not smoke. because tobacco smoke contains carcinogenic polycyclic aromatic hydrocarbons (pahs), it was of interest to examine human cervical tissue for pah-dna adduct formation. here, we measured pah-dna adduct formation in cervical biopsies collected in follow-up among women who tested positive for carcinogeni ... | 2007 | 17583755 |
| neoplastic transformation of human bronchial cells by lead chromate particles. | particulate hexavalent chromium (cr(vi)) is a well-established human lung carcinogen with widespread exposure among people in occupational settings and the general public. however, no studies have examined the chromate-induced malignant transformation of human lung epithelial cells, its predominant target. human papillomavirus-immortalized human bronchial epithelial (bep2d) cells were used to better understand the mechanisms involved in human bronchial carcinogenesis induced by particulate chrom ... | 2007 | 17585109 |
| anal squamous intraepithelial lesions and condyloma in hiv-infected heterosexual men, homosexual men and women: prevalence and associated factors. | to assess the prevalence of and factors associated with squamous intraepithelial lesions and condyloma [human papillomavirus (hpv)-related lesions) in hiv-infected patients. | 2007 | 17589192 |
| induction of cd4-independent e7-specific cd8+ memory response by heat shock fusion protein. | infection with human papillomavirus type 16 (hpv16) is strongly associated with a number of disease states, of which cervical and anal cancers represent the most drastic endpoints. induction of t-cell-mediated immunity, particularly cytotoxic t lymphocytes (ctl), is important in eradication of hpv-induced lesions. studies have shown that heat shock protein fusion proteins are capable of inducing potent antigen-specific ctl activity in experimental animal models. in addition, e7-expressing tumors ... | 2007 | 17596433 |
| value of the international federation for cervical pathology and colposcopy (ifcpc) terminology in predicting cervical disease. | to evaluate the colposcopic accuracy according to the international federation for cervical pathology and colposcopy (ifcpc) 2002 terminology. | 2007 | 17596761 |
| worldwide prevalence and genotype distribution of cervical human papillomavirus dna in women with normal cytology: a meta-analysis. | we set out to estimate the age and genotype-specific prevalence of cervical human papillomavirus (hpv) dna in women with normal cervical cytology worldwide by meta-analysis of a systematic literature review. reports on hpv prevalence published between january, 1995, and january, 2005, were retrieved. to be included, studies required information on cervical cytology, plus detailed descriptions of study populations, methods used to collect cervical samples, and assays used for hpv dna detection an ... | 2007 | 17597569 |
| prevalence of human papillomavirus among croatian women attending regular gynecological visit. | human papillomavirus (hpv) infection has been identified as major risk factor for cervical intraepithelial neoplasia (cin) and invasive cervical cancer. about 40 hpv viral types are commonly found in the genital tract. most hpv infections resolve spontaneously, while persistent infection with oncogenic types, namely hpv 16 and 18 is necessary for cin to occur and progress to cancer. cervical screening is presently based on the pap smear that is designed to diagnose precancerous lesions and cervi ... | 2007 | 17598508 |