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[infectious resistance to antibiotics in haemophilus influenzae (author's transl)].ampicillin-resistant haemophilus influenzae does occur now in the frg. in one isolate a plasmid with resistance genes (r-factor) could be demonstrated as cause of the ampicillin resistance. this r-factor influences production of a beta-lactamase of the tem type which destroys ampicillin. the infectious nature of the ampicillin resistance was proven by the fact that it was transferable to other bacterial species through cocultivation. parallel to ampicillin resistance tetracycline resistant haemo ...1978305840
para-aminobenzoic acid. 1978305886
a dnase for apurinic/apyrimidinic sites associated with exonuclease iii of hemophilus influenzae.an endonuclease purified from hemophilus influenzae made single strand breaks in dna containing apurinic or apyrimidinic sites but had no detectable endonuclease activity on untreated native dna. the new 5'-termini created at the cleavage sites were base-free deoxyribose 5-phosphate residues. the enzyme preparation also catalyzed the exonucleolytic release of 5'-mononucleotides from bihelical dna and the hydrolysis of dna 3'-terminal phosphomonoesters. the phosphatase-exonuclease activity was in ...1978305919
purification of specific precipitinogen and extraction of endotoxin from haemophilus influenzae.after purifying a haemophilus influenzae precipitinogen from endotoxic activity by means of ultracentrifugation, column chromatography (sepharose 6b) and ion exchange chromatography (deae sephadex a25) a fraction was obtained which still contained a specific precipitinogen that was virtually free of endotoxin. furthermore, during the chromatographic procedures fractions with a high and a low molecular weight endotoxic activity were found. the limulus lysate test was more sensitive in the high mo ...1978305926
evidence against the reversion of mutation in the haemophilus influenzae phage hp1c1 by preinfection treatment of host cells or phage with mnng.n-methyl-n'-nitrosoguanidine (mnng) causes reversion of a temperature-sensitive mutation in a bacteriophage of haemophilus influenzae if exposure to the mutagen takes place after infection but before lysis. however, neither pre-infection treatment of the phage dna, host cells, or both will cause reversion. the reasons for this are discussed in relation to the somewhat different results in the escherichia coli lambda phage system and in relation to error-prone repair and replication processes.1978306062
hip joint infections in infants and children. 1978306087
effect of ampicillin and chloramphenicol against haemophilus influenzae.synergy, determined by isobolograms constructed from the minimal inhibitory concentrations of combinations of ampicillin and chloramphenicol, was observed against six of 13 ampicillin-susceptible haemophilus influenzae type b isolates and against five of eight ampicillin-resistant strains by using a small inoculum of 10(4) colony forming units (cfu) per milliliter. synergy occurred against nine of 13 ampicillin-susceptible and against two of eight ampicillin-resistant strains using a large inocu ...1978306090
radiometric detection of haemophilus influenzae in cerebrospinal fluid specimens.the investigation demonstrates the usefulness of a radiometric urease test in the rapid detection of haemophilus influenzae in cerebrospinal fluid specimens. the test is simple and economical to perform and results are obtained within a one hour incubation period.1978305614
[a study on periodontal dressing materials. part 7. the effects of liquid of periodontal dressing materials on the capillary permeability of subcutaneous tissue of rabbit (author's transl)]. 1978296221
[changes in bovine mandible during fetal development; combined microradiographic, x-ray diffractometric and thermogravimetric investigation]. 1978296266
ampicillin-resistant hemophilus influenzae.ampicillin-resistant hemophilus influenzae had not been identified in fresno, california, before june 1976. in the 12 months that followed, eight resistant type b strains and three resistant nontypable isolates were cultured from patients treated at two hospitals that provide nearly all of the acute pediatric inpatient care for the area. two of the resistant strains were obtained from patients with invasive infections and represented 4.2 percent of hemophilus influenzae isolated from blood, cere ...1978305157
meningitis due to chloramphenicol-resistant haemophilus influenzae type b. 1978305271
mapping of the single cleavage site in s13 replicative form dna of hemophilus influenzae (hind iii) restriction enzyme. 1978304632
hemophilus influenzae pneumonia in adults.hemophilus influenzae pneumonia was diagnosed in 41 adult patients based on cultures of blood, pleural fluid or transtracheal aspirate. bacteremia occurred in all age groups, but was most frequent in patients over the age of 50 years with severe underlying pulmonary disease. chest films usually demonstrated multisegmental or multilobar infiltrates without evidence of cavitation. pleural involvement was evident in half of the patients, although empyema occurred infrequently. mortality was almost ...1978304671
comparison of rapid methods of antimicrobial susceptibility in haemophilus influenzae.a method is described for the rapid, simultaneous determination of the mic's of chloramphenicol and ampicillin to haemophilus influenzae. excellent agreement was observed between the autobac method and the agar dilution method for antimicrobial susceptibility. all ampicillin resistant haemophilus isolates produced beta lactamase and none of the suceptible strains produced this enzyme.1978304695
characterization of the immunoprotective antigen of ribosomal preparations from haemophilus influenzae.this investigation was designed to characterize the immunoprotective antigen of ribosomal preparations from haemophilus influenzae. the ribosomes that elicited 80 to 90% protection contained 25% protein and 75% ribonucleic acid but did not contain any detectable hexoses. the immunodiffusion and hemagglutination inhibition tests also failed to demonstrate that the capsular material (polyribose phosphate) was in ribosomal preparations. treatment of ribosomes with ribonuclease degraded 78% ribonucl ...1978304844
bacteremia associated with haemophilus influenzae type e biotype 4.haemophilus influenzae type e biotype 4 was isolated from a single antemortem blood culture obtained from a 60-year-old, white male with abdominal carcinomatosis.1978304860
detection of capsulated haemophilus influenzae in chest infections by counter current immunoelectrophoresis.the application of counter current immunoelectrophoresis to the detection of haemophilus influenzae capsular antigen in sputum is described. the method, technically simple, provided results within 30 minutes. h. influenzae capsular antigen was detected in 12% of patients and in 54.8% of the h. influenzae strains isolated. the test was not impaired by prior antibiotic therapy.1978304861
development of ampicillin-resistance during treatment of haemophilus influenzae pneumonia. 1978304475
an improved method for detection of hemophilus influenzae b antigen in cerebrospinal fluid. 1978304476
ampicillin-resistant followed by ampicillin-sensitive hemophilus influenzae meningitis in a normal host. 1978304477
resistance of h. influenzae to ampicillin. 1978304479
acute epiglottitis and systemic infection with hemophilus influenzae. 1978304374
cell-mediated immune response to dog pulp tissue altered by eugenol within the root canal.after pulpal extirpation of twenty teeth in each of four dogs, these animals were primarily immunized intramuscularly with the dog's own pulp (three dogs) and saline solution with pulp (one dog). a fifth dog was used as a control for skin tests. secondary immunizations were accomplished via the root canal every 7 days over a 28-day period. cell-mediated skin-test reactions demonstrated less of a response to the eugenol alone than when the dog's pulp was incubated with this material. in vitro ana ...1978273194
modification of "c" synapses following partial central deafferentation of thoracic motoneurones. 1978273463
evolutionary adaptation of membranes to temperature.the "fluidity" of brain synaptosomal membrane preparations of arctic and hot-springs fish species, two temperature water fish species acclimated to different seasonal temperatures, and two mammals was estimated using the fluorescence polarization technique. at all measurement temperatures, the fluidity decreased in the order: arctic sculpin, 5 degrees-acclimated goldfish, 25 degrees-acclimated goldfish, desert pupfish, and rat. this correlated with increasing adaptation or body (i.e., cellular) ...1978273929
localization of eukaryotic initiation factor 3 on native small ribosomal subunits.the localization of eukaryotic initiation factor 3(eif-3) on native small ribosomal subunits has been established by electron microscopy through a comparison of native small ribosomal subunits with derived subunits and with native subunits stripped of eif-3. small subunits derived from reticulocyte ribosomes by the puromycin/kcl method are seen in electron micrographs as elongated particles, divided by a heavily stained partition into approximately one-third and two-third domains. most particles ...1978274727
[periodontal treatment in general dental practice with emphasis on rational and effective working methods]. 1978274845
[total replacement of the temporomandibular joint by means of alloplastic materials. i]. 1978274848
[spatial variations of the mechanical properties of dental enamel and dentin].cuts with a vickers diamond were made in five horizontal planes of the upper third of the crown of human lower premolars. at the same time the depth of entry was registered directly during the cutting with adot screen with a distance of about 150 mu between the dots. the depth of the cuts obtained was determined by optical measurement of breadth. only in the fissure enamel was a slight hardening in the cervical direction observed. with a 5 p loading of the cutter diamond the reversible (elastic) ...1978275054
immune reactivity of rbl-3, a nonproducer leukemia induced by rauscher murine leukemia virus in c57bl/6 mice.a cultured line of rbl-3 leukemia, induced by rauscher murine leukemia virus (r-mulv) in c57bl/6 mice, was found to be a virus nonproducer. an nb tropic virus indistinguishable from r-mulv, however, was recovered after treatment with 5-iodo-2'-deoxyuridine (optimal concentration, 200 microgram/ml). dexamethasone treatment slightly boosted the production of the activated virus but did not by itself activate the virus. rbl-3 cells were found to have fc receptors but no surface immunoglobulin or th ...1978276620
in vivo and in vitro study of 59fe uptake in developing rat molars.autoradiographic methods were used to study 59fe uptake in vivo in mineralizing tissues of young rats. localization of 59fe was observed in the ameloblastic layers of molars. in vitro studies were performed which demonstrated that 59fe uptake in developing rat molar enamel was limited by the metabolic activity of the cells of the enamel organ.1978281101
biosynthesis of phosphoprotein by rat incisor odontoblasts in in-vitro culture. 1978281203
development of a minimal medium for streptococcus mutans. 1978281207
chemoimmunotherapy in disseminated melanoma and colorectal carcinoma.non-specific immunotherapy with monthly intramuscular injection of corynebacterium parvum has been investigated by randomized clinical trials in patients with advanced cancer. thirty-six patients with disseminated melanoma were treated with either imidazole carboxamide (dtic) alone or dtic plus c.parvum. a 19% objective response rate was observed. the mean survival time was similar for both groups. thirty-three patients with disseminated colorectal cancer were treated with either 5-fluorouracil ...1978281221
viral arthritis and the possible role of viruses in rheumatoid arthritis. 1978281924
binding of hla antigen-containing liposomes to bacteria.highly purified, detergent-solubilized hla-a and -b antigens and hla-d antigens were separately incorporated into liposomes. detergent-solubilized transplantation antigens, but not papain-solubilized antigens lacking the membrane-integrated portions of the molecules, were bound to the liposomes. a considerable portion of the liposome-bound antigens displayed accessible antigenic sites, suggesting that they were oriented in the right-side-out direction. liposomes containing the hla-a and -b antig ...1978282637
gentamicin and amikacin---an in vitro comparison using 1000 clinical isolates.the in vitro antimicrobial activities of gentamicin and amikacin against 1000 bacterial isolates from clinical material were compared. the minimum inhibitory concentrations were determined by an agar dilution technique. both of these aminoglycoside antibiotics had a similar spectrum of activity, being highly active against most species of aerobic gram negative bacilli. gentamicin was more active than amikacin against most species of enterobacteria, haemophilus influenzae and staphylococcus aureu ...1978282852
[biological importance of the periodontal ligament]. 1978284675
comparison of bl-s786 with cephalothin, cefamandole and cefoxitin in vitro and in treatment of experimental infections in mice.the activity of bl-s786 was compared to that of cephalothin, cefamandole and cefoxitin in vitro and in treatment of experimental infections in mice. in broth dilution tests, the activity of bl-s786 was less than cephalothin or cefamandole against staphylococcus aureus and less than cefamandole or cefoxitin against haemophilus influenzae. bl-s786 and cefamandole were the two most active drugs against cephalothin-sensitive enterobacteriaceae. in tests with cephalothin-resistant enterobacteriaceae, ...1978306989
increasing incidence of ampicillin resistance in hemophilus influenzae.the incidence of ampicillin resistance in hemophilus influenzae and its medical significance have not been extensively determined. during 1975-1977, we tested for ampicillin resistance 489 consecutive middle-ear isolates of hi obtained from children in huntsville, alabama, and 719 consecutive laboratory isolates of hi from children's hospital, boston. the annual incidence of amp resistance rose progressively in each survey, from initial values of 1.4 to 5.3% in 1975, to 14 to 16% in 1977 (p less ...1978307055
treatment of haemophilus influenzae meningitis. 1978307066
case report. ampicillin-resistant hemophilus influenzae type b orbital cellulitis. 1978307088
extracellular nucleases of pseudomonas bal 31. iii. use of the double-strand deoxyriboexonuclease activity as the basis of a convenient method for the mapping of fragments of dna produced by cleavage with restriction enzymes.we have previously characterized an extracellular nuclease from pseudomonas bal 31 which, in addition to other activities, displays a double-strand exonuclease activity which progressively shortens both strands of linear duplex dna molecules from both termini. this degradation is accomplished without the introduction of detectable scissions away from the ends of the duplexes. when this nuclease is used to produce a series of progressively shortened samples from a linear duplex dna, subsequent di ...1978307230
diagnosis of pneumonia by counterimmunoelectrophoresis of respiratory secretions.several recent studies in adults have indicated that counterimmunoelectrophoresis (cie) of sputum can distinguish persons with pneumococcal pneumonia vs those in whom merely colonization of pneumococcus occurs--cie being positive in the former and negative in the latter. counterimmunoelectrophoretic determinations were done on nasopharyngeal (np) secretions in 20 children with bacterial pneumonia as evidenced by physical and radiological findings, leukocytosis, response to a penicillin, and in s ...1978307343
hemophilus influenzae type f pneumonia in adults.a 69-year-old man was hospitalized with fatal bacteremic hemophilus influenzae type f pneumonia. three cases of type f pneumonia have been reported previously. when compared with 22 reported cases of bacteremic type b pneumonia, patients with type f infection were more likely to be elderly males who succumbed to their infection (p less than 0.05). statistically significant differences in the incidence of underlying conditions or in the extent of pneumonia were not present.1978307346
nitrate reduction: new method for testing the antibiotic susceptibility of haemophilus influenzae.we have developed a new micro-broth-dilution assay for determining the antimicrobial susceptibility of haemophilus influenzae. this assay is based on the ability of viable h. influenzae to reduce nitrates to nitrites. bacterial viability is detected by a positive nitrite reaction rather than visible turbidity. the nitrate reduction assay was compared with a standard microassay using 51 isolates of h. influenzae and six beta-lactam antibiotics. although there was good agreement between the two me ...1978307365
restriction enzyme analysis of plasmids from haemophilus influenzae.examination of haemophilus influenzae strains isolated in new orleans revealed ampicillin-resistant strains with plasmids of size classes not previously detected in north america. the molecular weight of plasmids in five ampicillin-resistant strains ranged from 0.8 x 10(6) daltons (0.8 mdal) to 36 mdal. the molecular weights of the plasmids were determined by sucrose gradient centrifugation, electron microscopy, and agarose gel electrophoresis. plasmids of the previously detected 30-mdal size cl ...1978307366
in vitro susceptibility of haemophilus influenzae to sulfamethoxazole-trimethoprim and cefaclor, cephalexin, and cephradine.sulfamethoxazole-trimethoprim and three oral cephalosporins, cefaclor, cephalexin, and cephradine, were evaluated in vitro as possible alternatives to chloramphenicol in the treatment of non-central nervous system infections due to ampicillin-resistant haemophilus influenzae. sixty-four isolates of h. influenzae, including 31 beta-lactamase-positive strains, were tested by the agar dilution method. all strains were inhibited by 0.78/0.039 mug sulfamethoxazole-trimethoprim per ml and by 0.78 mug ...1978307367
haemophilus influenzae susceptibility testing within four hours by a modification of the autobac i system.by adding an xv strip to the eugonic broth or substituting levinthal broth, the standard autobac i susceptibility testing system may be used to determine susceptibility of haemophilus influenzae to antimicrobial agents. complete concordance was attained in testing 30 strains (5 resistant) by autobac i, disk diffusion, and broth dilution methods. autobac i results were available within 4 h after isolation of the organism.1978307368
experimental haemophilus influenzae type b meningitis: immunological investigation of the infant rat model.infant rats inoculated intraperitoneally with haemophilus influenzae type b develop bacteremia and meningitis. rats were infected at 10 to 12 days of age and studied for the development of serum anticapsular antibody and bactericidal and opsonizing activity. seven and 11 weeks after inoculation, convalescent animals showed a higher frequency of anticapsular antibody responses than uninfected controls, but 35 to 40% of the infected group had undetectable levels of anticapsular antibody (<0.10 mug ...1978307539
biochemical characteristics of haemophilus influenzae in relationship to source of isolation and antibiotic resistance.based on a limited number of biochemical properties, a system for biotyping haemophilus influenzae (m. kilian, acta pathol. microbiol, scand. sect. b82:835-842, 1976) was used to analyze the relationship of biotype to source of infection and antibiotic resistance for 600 clinical strains. the distribution of biotypes from bacteremic patients was significantly different (p less than 0.001) from the distribution of biotypes from nonbacteremic patients. although there appeared to be a correlation b ...1978307559
the induction of hapten-specific immunologic tolerance and immunity in b lymphocytes. iii. in vitro evaluation of tnp-specific tolerance and evidence for b cell deletion. 1978307573
influence of specificity of reagents and of behaviour of cell surface ig on the detection and enumeration of immunoglobulin-bearing lymphocytes in humans.some parameters likely to influence detection and classification of human b-lymphocytes using anti-immunoglobulin (ig) sera have been investigated. of 20 separate mono- and polyspecific native or conjugated anti-ig sera analysed by a passive haemagglutination technique, 13 exhibited non-specific reactivity. this technique showed no consistent correlation between the titre of individual sera against fab2 and whole igg respectively. the indirect immunofluorescence (if) method applied to detect sur ...1978307583
hemophilus influenzae infection in the neonate mimicking respiratory distress syndrome. 1978307594
[haemophilus influenzae et parainfluenzae: determination of the biotype]. 1978307738
diagnosis of haemophilus influenzae type b pericarditis by counterimmunoelectrophoresis.a 6-year-old girl developed pericardial tamponade because of pericarditis caused by haemophilus influenzae type b. bacteriological cultures of the pericardial exudate were negative. the etiological diagnosis was established by counterimmunoelectrophoresis (cie).1978307808
hypergammaglobulinemic purpura in cystic fibrosis.four patients are presented aged 14 to 20 years with cystic fibrosis and recurrent purpura of the legs. they have polyclonal increase of ig but no intermediate complexes demonstrable by ultracentrifugation. the 4 patients differ from other patients with cystic fibrosis by a rapid deterioration of the clinical condition after the establishment of permanent pulmonary infection, and also by their proneness to haemophilus influenzae infections. the clinical and laboratory findings are compatible wit ...1978307897
clinical and laboratory investigation of cefamandole in infections of infants and children.forty-seven infants and children with a variety of infections including bacteremia, ethmoiditis, and periorbital cellulitis, soft tissue infection, pneumonia, and lymphadenitis were treated with intravenous cefamandole. the infections were due to staphylococcus aureus, streptococcus pyogenes, streptococcus pneumoniae, and haemophilus influenzae. the clinical response was prompt, and, with the exception of two cases who developed skin rash, significant side effects were not noted. in vitro cefama ...1978307939
susceptibility of haemophilus influenzae type b to rifampin and sulfisoxazole.a total of 100 and 97% of haemophilus influenzae type b strains from major infections were susceptible, respectively, to levels of rifampin and sulfisoxazole attainable in saliva. it is theoretically feasible to eliminate haemophilus influenzae from the nasopharynx with these drugs.1978307940
antibiotic resistance in haemophilus influenzae. 1978307973
septic arthritis of the hip in infancy: end result study.twenty-four hips in 21 patients suffering septic arthritis at infancy were followed 11-30 years (mean 17 years). fourteen hips with none to moderate femoral head destruction proved to have a fairly good chance of becoming located following closed treatment. if it failed, open reduction was successful, provided the femoral head-neck was big enough to achieve a stable reduction. out of the 10 hips with absent femoral head-neck and an iliac dislocation, 6 underwent trochanteric arthroplasty: 3 hips ...1978307996
common bacterial infections in infancy and childhood. 5. infections of the skeletal system. 1978308004
haemophilus influenzae amnionitis associated with prematurity and premature membrane rupture.prematurity and premature rupture of the membranes present major obstetric problems. when associated with amnionitis, the result may be disastrous. a case of haemophilus influenzae aminionitis in association with premature rupture of the membranes is presented. the rarity of this organism as a causative agent in amnionitis and its possible causative role in premature membrane rupture are considered in review of the scant relevant literature.1978308211
beta-lactamases and r-plasmids of haemophilus influenzae.the emergence of resistance to ampicillin and other antibiotics in haemophilus influenzae has been a relatively recent event. in contrast, drug resistance has been rampant in the enterobacteriaceae for many years. ampicillin-resistance in h. influenzae is almost invariably attributable to possession of the tem (type iii a)beta-lactamase. as is common in other bacteria the gene specifying this enzyme is plasmid-borne in haemophilus. some ampicillin-resistant strains of h. influenzae can transfer ...1978308259
studies with cefuroxime and cefoxitin.we have studied cefuroxime, a new beta-lactamase resistant cephalosporin, and cefoxitin, the first cephamycin antibiotic, which is also resistant to many beta-lactamases. both of these antibiotics have been shown to be microbiologically superior to the "first generation" cephalosporins, cefuroxime having notable activity against haemophilus influenzae, and cefoxitin against bacteroides fragilis. neither antibiotic is absorbed from the gut but, following parenteral administration, serum, urine an ...1978308260
spread of haemophilus influenzae. secondary illness in household contacts of patients with h influenzae meningitis.to determine the risk of severe secondary illness in household contacts of patients with haemophilus influenzae meningitis, telephone interviews were conducted with contacts of patients with reported cases. four probable or proved secondary cases of severe disease were identified for a secondary attack rate of 0.4%. the secondary attack rate for household contacts of patients 2 years of age and younger was 4.9%. until safe, effective prophylactic measures become available, physicians should expl ...1978308312
transferable chloramphenicol and ampicillin resistance in a strain of haemophilus influenzae.a strain of haemophilus influenzae isolated from sputum has been shown to be resistant to chloramphenicol, ampicillin, and tetracycline. all three resistances were transferred together to recipients when the selecting antibiotic was ampicillin, chloramphenicol, or tetracycline.1978308347
haemophilus influenzae cellulitis.cellitis that is caused by haemophilus influenzae demonstrates a unique predilection for the faces of young children. although previously considered a rare entity, it is currently being recognized more frequently. despite the importance of early recognition and treatment in preventing potentially fatal complications, it has been noticeably neglected in the otolaryngologic literature. we report a case and discuss the diagnosis and management of h influenzae cellulitis.1978308365
cortical blindness associated with occipital atrophy: a complication of h. influenzae meningitis. 1978308472
earache and coma. 1978308490
cefotoxime (hr 756) a new cephalosporin with exceptional broad-spectrum activity in vitro. 1978308505
activity of hr 756 against haemophilus influenzae, bacteroides fragilis and gram-negative rods. 1978308506
synchronous division and rates of macromolecular synthesis in haemophilus influenzae competent for genetic transformation.when competent haemophilus influenzae were returned to complete growth medium, they resumed growth at once and underwent a synchronous division after 20 to 25 min. the rate of dna synthesis increased to the definitive rate very quickly after resumption of growth. in contrast, the rate of rna synthesis remained low until the time of division, at which time it accelerated dramatically. changes in the rate of protein synthesis were similar in form to those of rna synthesis. the kinetics of loss of ...1978308508
effect of tmp-smx on nasopharyngeal carriage of ampicillin-sensitive and ampicillin-resistant hemophilus influenzae type b.the carriage rate of ampicillin-resistant hemophilus influenzae type b in a chronic care facility was investigated. up to 48% of the children carried this strain. of interest was the finding of simulaneous carriage of ampicillin-resistant and ampicillin-sensitive hitb, a phenomenon which was detected by using both chocolate agar and chocolate agar containing 2 microgram/ml of ampicillin. a trial of sulfamethoxazole-trimethoprin successfully eradicated the ampicillin-sensitive hitb, but had no ef ...1978308533
acute glossitis due to hemophilus influenzae type b. 1978308534
from the nih: haemophilus influenzae type b meningitis can occur in children with natural exposure to only a small number of organisms. 1978308547
pyrimidine nucleoside phosphorylase from haemophilus influenzae. 1978308598
purulent pericarditis in children.acute purulent pericarditis was treated successfully in five children between the ages of 27 months and 11 1/2 years during the past 5 years. the responsible organism was hemophilus influenzae, type b, in two cases and meningococcus, pneumococcus, and coagulase-positive staphylococcus aureus in one case each. no primary source of infection could be identified in two patients. a high index of suspicion, combined with immediate echocardiograms and pericardiocentesis, led to the diagnosis. immediat ...1978308705
purine reutilization in phytohemagglutinin-stimulated human t-lymphocytes. 1978308885
anatomy of the surface of the articular disk of the temporo-mandibular articulation in man, seen with the scanning microscope. 1978308903
genetic control of the content and avidity of hapten-binding b lymphocytes in mouse spleen. 1978308926
characterization and mitogenic activity of haemophilus influenzae type b capsular polysaccharide.studies were conducted on the characterization of haemophilus influenzae type b polysaccharide (hitb-ps) and its mitogenic activity upon peripheral lymphocytes. this capsular polysaccharide was found to contain hexosamines and hexoses in addition to the main components of ribose and ribitol phosphate. the molecular weight of hitb-ps was determined as 585,000. the affinity constant of hitb-ps to unfractionated lymphocytes was 3.13 x 10(3) m-1 with 1.11 x 10(4) binding sites per cell. hitb-ps was ...1978308927
influenzal pneumonia: early appearance of cross-reactive t cells in lungs of mice primed with heterologous type a viruses.mice were first primed with a type a or a type b influenza virus and then challenged intranasally at least 1 month later with another type a virus. potent cytotoxic t cell populations were found in lung, and effector t cell function was also demonstrated in blood, spleen and mediastinal lymph nodes. lymphocytes isolated from all of these anatomical sites were active against target cells infected with the same, or with serologically different, type a influenza viruses. also, prior exposure to ano ...1978308930
prevalence of ampicillin- and chloramphenicol-resistant strains of haemophilus influenzae causing meningitis and bacteremia: national survey of hospital laboratories. 1978308974
role of the h-2 complex in induction of t helper cells in vivo. i. antigen-specific selection of donor t cells to sheep erythrocytes in irradiated mice dependent upon sharing of h-2 determinants between donor and host.when purified cba lymph node t cells were mixed with sheep erythrocytes (src) and filtered from blood to lymph through irradiated syngeneic mice for 1-2 days, the donor cells lost their capacity to stimulate anti-src responses by cba b cells; the response to a third-party antigen (horse erythrocytes) was unaffected and active suppression was not involved. this process of specific negative selection to src also occurred when semiallogeneic mice were used as filtration hosts. by contrast, when all ...1978308981
influenza virus infection in newborn rats: a possible marker of attenuation for man.the growth of parent influenza viruses a/england/939/69 and a/pr/8/34, and clones 6, 7, and 64c, derived by recombination, was studied in newborn rats. using an inoculum of 10(4.0) eid50, influenza virus a/england/939/69 produced the highest titres of virus in rat turbinates at 48 hours after inoculation; clones 6 and 7 and a/pr/8/34 grew to lower titres; and clone 64c grew to the lowest titre. these differences were less apparent when 10(2.0) eid50 of virus was used as an inoculum, and rats wer ...1978308996
apparatus for uniaxial testing of soft human tissues in vitro. 1978309051
periorbital cellulitis in children. 1978309105
[cefuroxim, a new beta-lactamase stable cephalosporin].in vitro activity of cefuroxime, a new cephalosporin stable to bacterial beta-lactamases, was compared with that of cefalothin and other cephalosporins by serial dilution test in more than 600 bacterial strains. cefuroxime was more active than cefalothin on most strains of gram negative bacilli (except salmonella species) and also on most strains of cefalothin-resistant bacteria. in comparison to cefalothin, cefoxitin and cefamandol, cefuroxime exerted the strongest activity on meningococci, str ...1978309178
cp-45,899, a beta-lactamase inhibitor that extends the antibacterial spectrum of beta-lactams: initial bacteriological characterization.cp-45,899 {3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 4,4-dioxide, [2s-(2alpha,5alpha)]} is an irreversible inhibitor of several bacterial penicillinases and cephalosporinases. in the presence of low concentrations of cp-45,899, ampicillin and other beta-lactams readily inhibit the growth of a variety of resistant bacteria that contain beta-lactamases. cp-45,899 used alone displays only weak antibacterial activity, with the notable exception of its potent effects on ...1978309306
role of immunity in the clearance of bacteremia due to haemophilus influenzae.the role of antibodies to capsular and somatic antigens in the clearance of haemophilus influenzae was investigated by active and passive immunization. the clearance index (k) and the proportion of strain b organisms cleared 30 min after intravenous administration (deltay30) were greater in eight-week-old actively immunized rats (k = 0.693, deltay30 = 4.07) than in nonimmune animals (k = 0.075, deltay30 = 0.95)(p less than 0.025 for all); however, clearance correlated imprecisely with titers of ...1978309494
congenital vesicular eruption caused by haemophilus influenzae type b.we report a case of perinatal infection that we believe is the first documented report of a congenital vesicular eruption due to haemophilus influenzae type b and the second report of puerperal sepsis with this organism. a vesicular eruption was noted at birth on an infant delivered at 37 weeks following 34 hours' premature rupture of membranes. gram-negative rods were seen on gram stain of vesicular fluid, and h. influenzae type b grew on cultures of vesicular fluid. the mother sustained postpa ...1978309588
many bacterial species are mitogenic for human blood b lymphocytes.thirty bacterial species were tested for their ability to stimulate to increased dna synthesis in human blood lymphocytes. a definite stimulation was obtained with eighteen bacterial species. for three of these species ten different strains of each were tested, and all increased dna synthesis. the maximum response was after 3--4 days of culture, suggesting a mitogenic effect. this was confirmed by the induction of polyclonal antibody production shown by a plague assay, which was positive for nin ...1978309629
two cases of septicemia caused by noncapsulated strains of haemophilus influenzae. 1978309630
hemophilus influenzae f cellulitis with bacteremia, peritonitis, and pleuritis in an adult with nephrotic syndrome.hemophilus influenzae f was responsible for cellulitis with bacteremia, pleuritis, and peritonitis in an adult patient with the nephrotic syndrome. the patient rapidly responded to ampicillin. h influenzae f has previously been rarely found to cause pleuritis and bacteremia, but has not been reported as a cause of cellulitis or primary peritonitis. patients with the nephrotic syndrome are prone to serious infection with encapsulated bacteria. the relative frequency of infection with the various ...1978309658
bulging (sagging) fissure sign in hemophilus influenzae lobar pneumonia.a bulging fissure sign was noticed on chest roentgenogram in a patient with h influenzae pneumonia. this sign is usually associated with klebsiella pneumonia and has also been seen in pneumococcal and plague pneumonia, tuberculosis, mass lesions of the lung, and large lung abscesses. this is thought to be the first report of a bulging fissure sign associated with pneumonia due to h influenzae.1978309660
haemophilus influenzae sepsis in the premature infant. 1978309717
haemophilus influenzae infections. 1978309718
radiological case of the month. 1978309719
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