Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| microbiological characteristics of sepsis in a university hospital. | microbiological characteristics of sepsis and antimicrobial resistance are well studied, although in state university of campinas, no data has been published yet. | 2015 | 25887416 |
| unprecedented silver resistance in clinically isolated enterobacteriaceae: major implications for burn and wound management. | increased utilization of inorganic silver as an adjunctive to many medical devices has raised concerns of emergent silver resistance in clinical bacteria. although the molecular basis for silver resistance has been previously characterized, to date, significant phenotypic expression of these genes in clinical settings is yet to be observed. here, we identified the first strains of clinical bacteria expressing silver resistance at a level that could significantly impact wound care and the use of ... | 2015 | 26014954 |
| rapid and reliable identification of gram-negative bacteria and gram-positive cocci by deposition of bacteria harvested from blood cultures onto the maldi-tof plate. | rapid identification of the causative agent(s) of bloodstream infections using the matrix-assisted laser desorption/ionization time-of-flight (maldi-tof) methodology can lead to increased empirical antimicrobial therapy appropriateness. herein, we aimed at establishing an easier and simpler method, further referred to as the direct method, using bacteria harvested by serum separator tubes from positive blood cultures and placed onto the polished steel target plate for rapid identification by mal ... | 2015 | 26084329 |
| an updated review of terminalia catappa. | terminalia catappa linn. is known for its nutritional fruit and possesses medicinal benefits as well. this is a comprehensive review of the phytoconstituents and pharmacological benefits. t. catappa has been recognized for its medicinally essential phytoconstituents, such as phenol, flavonoid, and carotenoid. numerous pharmacological investigations have confirmed this plant's ability to exhibit antimicrobial, anti-inflammatory, antidiabetic, antioxidant, hepatoprotective, and anticancer activiti ... | 2015 | 26392705 |
| root-associated bacterial endophytes from ralstonia solanacearum resistant and susceptible tomato cultivars and their pathogen antagonistic effects. | this study was undertaken to assess if the root-associated native bacterial endophytes in tomato have any bearing in governing the host resistance to the wilt pathogen ralstonia solanacearum. internal colonization of roots by bacterial endophytes was confirmed through confocal imaging after syto-9 staining. endophytes were isolated from surface-sterilized roots of 4-weeks-old seedlings of known wilt resistant (r) tomato cultivar arka abha and susceptible (s) cv. arka vikas on nutrient agar after ... | 2015 | 25926818 |
| intra- and inter-species interactions within biofilms of important foodborne bacterial pathogens. | a community-based sessile life style is the normal mode of growth and survival for many bacterial species. under such conditions, cell-to-cell interactions are inevitable and ultimately lead to the establishment of dense, complex and highly structured biofilm populations encapsulated in a self-produced extracellular matrix and capable of coordinated and collective behavior. remarkably, in food processing environments, a variety of different bacteria may attach to surfaces, survive, grow, and for ... | 2015 | 26347727 |
| evaluation of antimicrobial therapy of blood culture positive healthcare-associated infections in children. | knowledge of the quality of antimicrobial therapy (amt) used for invasive healthcare-associated infections (hais) in paediatrics is scarce. influence of the final information about the isolated pathogen on the subsequent targeted amt was investigated in our study. | 2015 | 26539831 |
| port site infection in laparoscopic surgery: a review of its management. | laparoscopic surgery (ls), also termed minimal access surgery, has brought a paradigm shift in the approach to modern surgical care. early postoperative recovery, less pain, improved aesthesis and early return to work have led to its popularity both amongst surgeons and patients. its application has progressed from cholecystectomies and appendectomies to various other fields including gastrointestinal surgery, urology, gynecology and oncosurgery. however, ls has its own package of complications. ... | 2015 | 26488021 |
| persistence of nasal colonization with human pathogenic bacteria and associated antimicrobial resistance in the german general population. | the nares represent an important bacterial reservoir for endogenous infections. this study aimed to assess the prevalence of nasal colonization by different important pathogens, the associated antimicrobial susceptibility and risk factors. we performed a prospective cohort study among 1878 nonhospitalized volunteers recruited from the general population in germany. participants provided nasal swabs at three time points (each separated by 4-6 months). staphylococcus aureus, enterobacteriaceae and ... | 2015 | 26862431 |
| persistence of nasal colonization with human pathogenic bacteria and associated antimicrobial resistance in the german general population. | the nares represent an important bacterial reservoir for endogenous infections. this study aimed to assess the prevalence of nasal colonization by different important pathogens, the associated antimicrobial susceptibility and risk factors. we performed a prospective cohort study among 1878 nonhospitalized volunteers recruited from the general population in germany. participants provided nasal swabs at three time points (each separated by 4-6 months). staphylococcus aureus, enterobacteriaceae and ... | 2015 | 26862431 |
| optical scatter patterns facilitate rapid differentiation of enterobacteriaceae on chromagar™ orientation medium. | enterobacteriaceae family comprised pathogens and commensals and has a significant impact on food safety and public health. enterobacteriaceae is often enumerated and presumptively identified on chromogenic media, such as chromagar(tm) orientation medium based on colony profile; however, classification is highly arbitrary, and some could not be differentiated due to similar chromogen production. here, we investigated the ability of the laser optical sensor, bardot (bacterial rapid detection usin ... | 2015 | 26503189 |
| optical scatter patterns facilitate rapid differentiation of enterobacteriaceae on chromagar™ orientation medium. | enterobacteriaceae family comprised pathogens and commensals and has a significant impact on food safety and public health. enterobacteriaceae is often enumerated and presumptively identified on chromogenic media, such as chromagar(tm) orientation medium based on colony profile; however, classification is highly arbitrary, and some could not be differentiated due to similar chromogen production. here, we investigated the ability of the laser optical sensor, bardot (bacterial rapid detection usin ... | 2015 | 26503189 |
| evaluation of an inexpensive growth medium for direct detection of escherichia coli in temperate and sub-tropical waters. | the cost and complexity of traditional methods for the detection of faecal indicator bacteria, including e. coli, hinder widespread monitoring of drinking water quality, especially in low-income countries and outside controlled laboratory settings. in these settings the problem is exacerbated by the lack of inexpensive media for the detection of e. coli in drinking water. we developed a new low-cost growth medium, aquatest (at), and validated its use for the direct detection of e. coli in temper ... | 2015 | 26495983 |
| genetic islands in pome fruit pathogenic and non-pathogenic erwinia species and related plasmids. | new pathogenic bacteria belonging to the genus erwinia associated with pome fruit trees (erwinia, e. piriflorinigrans, e. uzenensis) have been increasingly described in the last years, and comparative analyses have found that all these species share several genetic characteristics. studies at different level (whole genome comparison, virulence genes, plasmid content, etc.) show a high intraspecies homogeneity (i.e., among e. amylovora strains) and also abundant similarities appear between the di ... | 2015 | 26379649 |
| development of molecular approach based on pcr assay for detection of histamine producing bacteria. | histamine fish poisoning becomes highly concern not only in public health but also economic aspect. histamine is produced from histidine in fish muscles by bacterial decarboxylase enzyme. several techniques have been developed to determine the level of histamine in fish and their products but the effective method for detecting histamine producing bacteria is still required. this study was attempted to detect histamine producing bacteria by newly developed pcr condition. histamine producing bacte ... | 2015 | 26787983 |
| development of molecular approach based on pcr assay for detection of histamine producing bacteria. | histamine fish poisoning becomes highly concern not only in public health but also economic aspect. histamine is produced from histidine in fish muscles by bacterial decarboxylase enzyme. several techniques have been developed to determine the level of histamine in fish and their products but the effective method for detecting histamine producing bacteria is still required. this study was attempted to detect histamine producing bacteria by newly developed pcr condition. histamine producing bacte ... | 2015 | 26787983 |
| isolation, characterization, and antibiotic resistance of vibrio spp. in sea turtles from northwestern mexico. | the aerobic oral and cloacal bacterial microbiota and their antimicrobial resistance were characterized for 64 apparently healthy sea turtles captured at their foraging grounds in ojo de liebre lagoon (oll), baja california sur (bcs), mexico (pacific ocean) and the lagoon system of navachiste (lsn) and marine area of influence (mai), guasave, sinaloa (gulf of california). a total of 34 black turtles (chelonia mydas agassizii) were sampled in oll and eight black turtles and 22 olive ridley turtle ... | 2015 | 26161078 |
| rapidec carba np test for rapid detection of carbapenemase producers. | performances of the rapidec carba np test (biomérieux) were evaluated for detection of all types of carbapenemases in enterobacteriaceae, acinetobacter baumannii, and pseudomonas aeruginosa. in less than 2 h after sample preparation, it showed a sensitivity and specificity of 96%. this ready-to-use test is well adapted to the daily need for detection of carbapenemase producers in any laboratory worldwide. | 2015 | 26085619 |
| involvement of aph(3')-iia in the formation of mosaic aminoglycoside resistance genes in natural environments. | intragenic recombination leading to mosaic gene formation is known to alter resistance profiles for particular genes and bacterial species. few studies have examined to what extent aminoglycoside resistance genes undergo intragenic recombination. we screened the genbank database for mosaic gene formation in homologs of the aph(3')-iia (nptii) gene. aph(3')-iia inactivates important aminoglycoside antibiotics. the gene is widely used as a selectable marker in biotechnology and enters the environm ... | 2015 | 26042098 |
| identification of nasal colonization with β-lactamase-producing enterobacteriaceae in patients, health care workers and students in madagascar. | this study assesses the nasal occurrence of β-lactamase-producing enterobacteriaceae both in patients in a hospital department of infectious diseases at admission and in healthy madagascan students and health care workers. nasal swabs from 681 students, 824 health care workers, and 169 patients were obtained in antananarivo, madagascar, and transferred to germany. screening for β-lactamase (esbl, ampc) producing enterobacteriaceae was performed by cultural and molecular approaches, comprising br ... | 2015 | 25908994 |
| validated predictive modelling of the environmental resistome. | multi-drug-resistant bacteria pose a significant threat to public health. the role of the environment in the overall rise in antibiotic-resistant infections and risk to humans is largely unknown. this study aimed to evaluate drivers of antibiotic-resistance levels across the river thames catchment, model key biotic, spatial and chemical variables and produce predictive models for future risk assessment. sediment samples from 13 sites across the river thames basin were taken at four time points a ... | 2015 | 25679532 |
| a comparison of the antimicrobial activity and toxicity of six combretum and two terminalia species from southern africa. | plants of the family combretaceae are amongst the most widely used plants for traditional medicinal purposes in southern africa. in particular, many species of combretum and terminalia are used for their antibacterial, antifungal, antiprotozoal, antiviral, antidiarrhoeal, analgesic, antimalarial, antioxidant, anti-inflammatory and anticancer activities, yet their antimicrobial potential has not been rigorously studied and compared. | 2015 | 25709234 |
| aerobic bacterial flora of biotic and abiotic compartments of a hyperendemic zoonotic cutaneous leishmaniasis (zcl) focus. | identification of the microflora of the sand fly gut and the environmental distribution of these bacteria are important components for paratransgenic control of leishmania transmission by sand flies. | 2015 | 25630498 |
| the three bacterial lines of defense against antimicrobial agents. | antimicrobial agents target a range of extra- and/or intracellular loci from cytoplasmic wall to membrane, intracellular enzymes and genetic materials. meanwhile, many resistance mechanisms employed by bacteria to counter antimicrobial agents have been found and reported in the past decades. based on their spatially distinct sites of action and distribution of location, antimicrobial resistance mechanisms of bacteria were categorized into three groups, coined the three lines of bacterial defense ... | 2015 | 26370986 |
| impact of the new delhi metallo-beta-lactamase on beta-lactam antibiotics. | since the first new delhi metallo-beta-lactamase (ndm) report in 2009, ndm has spread globally causing various types of infections. ndm-positive organisms produce in vitro resistance phenotypes to carbapenems and many other antimicrobials. it is thus surprising that the literature examining clinical experiences with ndm does not report corresponding poor clinical outcomes. there are many instances where good clinical outcomes are described, despite a mismatch between administered antimicrobials ... | 2015 | 26345624 |
| investigation of yersinia pestis laboratory adaptation through a combined genomics and proteomics approach. | the bacterial pathogen yersinia pestis, the cause of plague in humans and animals, normally has a sylvatic lifestyle, cycling between fleas and mammals. in contrast, laboratory-grown y. pestis experiences a more constant environment and conditions that it would not normally encounter. the transition from the natural environment to the laboratory results in a vastly different set of selective pressures, and represents what could be considered domestication. understanding the kinds of adaptations ... | 2015 | 26599979 |
| development of a rapid and simplified protocol for direct bacterial identification from positive blood cultures by using matrix assisted laser desorption ionization time-of- flight mass spectrometry. | bloodstream infections represent serious conditions carrying a high mortality and morbidity rate. rapid identification of microorganisms and prompt institution of adequate antimicrobial therapy is of utmost importance for a successful outcome. aiming at the development of a rapid, simplified and efficient protocol, we developed and compared two in-house preparatory methods for the direct identification of bacteria from positive blood culture flasks (bd bactec fx system) by using matrix-assisted ... | 2015 | 26546000 |
| maldi-tof mass spectrometry: an emerging technology for microbial identification and diagnosis. | currently microorganisms are best identified using 16s rrna and 18s rrna gene sequencing. however, in recent years matrix assisted laser desorption ionization-time of flight mass spectrometry (maldi-tof ms) has emerged as a potential tool for microbial identification and diagnosis. during the maldi-tof ms process, microbes are identified using either intact cells or cell extracts. the process is rapid, sensitive, and economical in terms of both labor and costs involved. the technology has been r ... | 2015 | 26300860 |
| in vitro activity of rx-p873 against enterobacteriaceae, pseudomonas aeruginosa, and acinetobacter baumannii. | rx-p873 is a novel antibiotic from the pyrrolocytosine series which exhibits high binding affinity for the bacterial ribosome and broad-spectrum antibiotic properties. the pyrrolocytosines have shown in vitro activity against multidrug-resistant gram-negative and gram-positive strains of bacteria known to cause complicated urinary tract, skin, and lung infections, as well as sepsis. enterobacteriaceae (657), pseudomonas aeruginosa (200), and acinetobacter baumannii (202) isolates from north amer ... | 2015 | 25645834 |
| cell wall recycling-linked coregulation of ampc and penb β-lactamases through ampd mutations in burkholderia cenocepacia. | in many gram-negative pathogens, mutations in the key cell wall-recycling enzyme ampd (n-acetyl-anhydromuramyl-l-alanine amidase) affect the activity of the regulator ampr, which leads to the expression of ampc β-lactamase, conferring resistance to expanded-spectrum cephalosporin antibiotics. burkholderia cepacia complex (bcc) species also have these amp homologs; however, the regulatory circuitry and the nature of causal ampd mutations remain to be explored. a total of 92 ampd mutants were obta ... | 2015 | 26416862 |
| multicenter evaluation of the bruker maldi biotyper ca system for the identification of clinical aerobic gram-negative bacterial isolates. | the prompt and accurate identification of bacterial pathogens is fundamental to patient health and outcome. recent advances in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (maldi-tof ms) have revolutionized bacterial identification in the clinical laboratory, but uniform incorporation of this technology in the u.s. market has been delayed by a lack of fda-cleared systems. in this study, we conducted a multicenter evaluation of the maldi biotyper ca (mbt-ca) system ... | 2015 | 26529504 |
| determinants of bacteriological outcomes in exacerbations of chronic obstructive pulmonary disease. | changes in sputum microbiology following antibiotic treatment of acute exacerbations of chronic obstructive pulmonary disease (aecopd), including patterns of bacteriological relapse and superinfection are not well understood. sputum microbiology at exacerbation is not routinely performed, but pathogen presence and species are determinants of outcomes. therefore, we determined whether baseline clinical factors could predict the presence of bacterial pathogens at exacerbation. bacterial eradicatio ... | 2015 | 26370552 |
| determinants of bacteriological outcomes in exacerbations of chronic obstructive pulmonary disease. | changes in sputum microbiology following antibiotic treatment of acute exacerbations of chronic obstructive pulmonary disease (aecopd), including patterns of bacteriological relapse and superinfection are not well understood. sputum microbiology at exacerbation is not routinely performed, but pathogen presence and species are determinants of outcomes. therefore, we determined whether baseline clinical factors could predict the presence of bacterial pathogens at exacerbation. bacterial eradicatio ... | 2015 | 26370552 |
| prevalence and impact of streptococcus pneumoniae in adult cystic fibrosis patients: a retrospective chart review and capsular serotyping study. | cystic fibrosis (cf) is a genetic disease characterized by complex polymicrobial communities within the lower respiratory tract. s. pneumoniae, while a well-defined pathogen in the general population, has rarely been identified in cf. furthermore, prevalence studies on pneumococcus in cf have predominantly focused on the infant and pediatric populations, and outcome data is lacking. | 2015 | 25930152 |
| a locked nucleic acid (lna)-based real-time pcr assay for the rapid detection of multiple bacterial antibiotic resistance genes directly from positive blood culture. | bacterial strains resistant to various antibiotic drugs are frequently encountered in clinical infections, and the rapid identification of drug-resistant strains is highly essential for clinical treatment. we developed a locked nucleic acid (lna)-based quantitative real-time pcr (lna-qpcr) method for the rapid detection of 13 antibiotic resistance genes and successfully used it to distinguish drug-resistant bacterial strains from positive blood culture samples. a sequence-specific primer-probe s ... | 2015 | 25775001 |
| bacteriological assessment of the hospital environment in two referral hospitals in yaoundé-cameroon. | many studies still show significant numbers of surgical patients contracting nosocomial infections each year globally with high morbidity and mortality. the aim of this study was to identify potential bacteria reservoirs that may be responsible for nosocomial infection in surgical services in the yaoundé university teaching hospital (yuth) and the central hospital yaoundé (chy). | 2015 | 26140067 |
| use of 16s rrna gene for identification of a broad range of clinically relevant bacterial pathogens. | according to world health organization statistics of 2011, infectious diseases remain in the top five causes of mortality worldwide. however, despite sophisticated research tools for microbial detection, rapid and accurate molecular diagnostics for identification of infection in humans have not been extensively adopted. time-consuming culture-based methods remain to the forefront of clinical microbial detection. the 16s rrna gene, a molecular marker for identification of bacterial species, is ub ... | 2015 | 25658760 |
| diversity and evolutionary analysis of iron-containing (type-iii) alcohol dehydrogenases in eukaryotes. | alcohol dehydrogenase (adh) activity is widely distributed in the three domains of life. currently, there are three non-homologous nad(p)+-dependent adh families reported: type i adh comprises zn-dependent adhs; type ii adh comprises short-chain adhs described first in drosophila; and, type iii adh comprises iron-containing adhs (feadhs). these three families arose independently throughout evolution and possess different structures and mechanisms of reaction. while types i and ii adhs have been ... | 2016 | 27893862 |
| prevalence and identification of burkholderia pseudomallei and near-neighbor species in the malabar coastal region of india. | accurate identification of pathogens with biowarfare importance requires detection tools that specifically differentiate them from near-neighbor species. burkholderia pseudomallei, the causative agent of a fatal disease melioidosis, is one such biothreat agent whose differentiation from its near-neighbor species is always a challenge. this is because of its phenotypic similarity with other burkholderia species which have a wide spread geographical distribution with shared environmental niches. m ... | 2016 | 27632353 |
| clinical relevance of molecular identification of microorganisms and detection of antimicrobial resistance genes in bloodstream infections of paediatric cancer patients. | bloodstream infections (bsis) are the major cause of mortality in cancer patients. molecular techniques are used for rapid diagnosis of bsi, allowing early therapy and improving survival. we aimed to establish whether real-time quantitative polymerase chain reaction (qpcr) could improve early diagnosis and therapy in paediatric cancer patients, and describe the predominant pathogens of bsi and their antimicrobial susceptibility. | 2016 | 27585633 |
| ceftazidime-avibactam versus doripenem for the treatment of complicated urinary tract infections, including acute pyelonephritis: recapture, a phase 3 randomized trial program. | the global emergence of carbapenem-resistant enterobacteriaceae highlights the urgent need to reduce carbapenem dependence. the phase 3 recapture program compared the efficacy and safety of ceftazidime-avibactam and doripenem in patients with complicated urinary tract infection (cuti), including acute pyelonephritis. | 2016 | 27313268 |
| a universal culture medium for screening polymyxin-resistant gram-negative isolates. | the colistin-containing superpolymyxin medium was developed for screening polymyxin-resistant gram-negative bacteria. it was evaluated with 88 polymyxin-susceptible or polymyxin-resistant cultured gram-negative isolates. its sensitivity and specificity of detection were ca. 100%. the superpolymyxin medium is the first screening medium that is able to detect intrinsic and acquired polymyxin-resistant bacteria. | 2016 | 26984971 |
| therapeutic manuka honey: no longer so alternative. | medicinal honey research is undergoing a substantial renaissance. from a folklore remedy largely dismissed by mainstream medicine as "alternative", we now see increased interest by scientists, clinical practitioners and the general public in the therapeutic uses of honey. there are a number of drivers of this interest: first, the rise in antibiotic resistance by many bacterial pathogens has prompted interest in developing and using novel antibacterials; second, an increasing number of reliable s ... | 2016 | 27148246 |
| evaluation of a fully automated research prototype for the immediate identification of microorganisms from positive blood cultures under clinical conditions. | a clinical laboratory evaluation of an intrinsic fluorescence spectroscopy (ifs)-based identification system paired to a bact/alert virtuo microbial detection system (biomérieux, inc., durham, nc) was performed to assess the potential for fully automated identification of positive blood cultures. the prototype ifs system incorporates a novel method combining a simple microbial purification procedure with rapid in situ identification via spectroscopy. results were available within 15 min of a bot ... | 2016 | 27094332 |
| diversity, evolution and medical applications of insect antimicrobial peptides. | antimicrobial peptides (amps) are short proteins with antimicrobial activity. a large portion of known amps originate from insects, and the number and diversity of these molecules in different species varies considerably. insect amps represent a potential source of alternative antibiotics to address the limitation of current antibiotics, which has been caused by the emergence and spread of multidrug-resistant pathogens. to get more insight into amps, we investigated the diversity and evolution o ... | 2016 | 27160593 |
| trypanosoma cruzi differentiates and multiplies within chimeric parasitophorous vacuoles in macrophages coinfected with leishmania amazonensis. | the trypanosomatids leishmania amazonensis and trypanosoma cruzi are excellent models for the study of the cell biology of intracellular protozoan infections. after their uptake by mammalian cells, the parasitic protozoan flagellates l. amazonensis and t. cruzi lodge within acidified parasitophorous vacuoles (pvs). however, whereas l. amazonensis develops in spacious, phagolysosome-like pvs that may enclose numerous parasites, t. cruzi is transiently hosted within smaller vacuoles from which it ... | 2016 | 26975994 |
| in vitro engineering of novel bioactivity in the natural enzymes. | enzymes catalyze various biochemical functions with high efficiency and specificity. in vitro design of the enzyme leads to novel bioactivity in this natural biomolecule that give answers of some vital questions like crucial residues in binding with substrate, molecular evolution, cofactor specificity etc. enzyme engineering technology involves directed evolution, rational designing, semi-rational designing, and structure-based designing using chemical modifications. similarly, combined computat ... | 2016 | 27774447 |
| bioprospecting sponge-associated microbes for antimicrobial compounds. | sponges are the most prolific marine organisms with respect to their arsenal of bioactive compounds including antimicrobials. however, the majority of these substances are probably not produced by the sponge itself, but rather by bacteria or fungi that are associated with their host. this review for the first time provides a comprehensive overview of antimicrobial compounds that are known to be produced by sponge-associated microbes. we discuss the current state-of-the-art by grouping the bioact ... | 2016 | 27144573 |
| detection of extended spectrum beta-lactamases resistance genes among bacteria isolated from selected drinking water distribution channels in southwestern nigeria. | extended spectrum beta-lactamases (esbl) provide high level resistance to beta-lactam antibiotics among bacteria. in this study, previously described multidrug resistant bacteria from raw, treated, and municipal taps of dwds from selected dams in southwestern nigeria were assessed for the presence of esbl resistance genes which include bla tem, bla shv, and bla ctx by pcr amplification. a total of 164 bacteria spread across treated (33), raw (66), and municipal taps (68), belonging to α-proteoba ... | 2016 | 27563674 |
| persistence of bacterial indicators and zoonotic pathogens in contaminated cattle wastes. | manure can provide a favourable environment for pathogens' survival. de-contamination may be conducted by extended storage, until field conditions are suitable for application to land as source of agricultural nutrients. | 2016 | 27206734 |
| host-specific functional significance of caenorhabditis gut commensals. | the gut microbiota is an important contributor to host health and fitness. given its importance, microbiota composition should not be left to chance. however, what determines this composition is far from clear, with results supporting contributions of both environmental factors and host genetics. to gauge the relative contributions of host genetics and environment, specifically the microbial diversity, we characterized the gut microbiotas of caenorhabditis species spanning 200-300 million years ... | 2016 | 27799924 |
| direct identification of urinary tract pathogens from urine samples, combining urine screening methods and matrix-assisted laser desorption ionization-time of flight mass spectrometry. | early diagnosis of urinary tract infections (utis) is essential to avoid inadequate or unnecessary empirical antibiotic therapy. microbiological confirmation takes 24 to 48 h. the use of screening methods, such as cytometry and automated microscopic analysis of urine sediment, allows the rapid prediction of negative samples. in addition, matrix-assisted laser desorption ionization-time of flight mass spectrometry (maldi-tof ms) is a widely established technique in clinical microbiology laborator ... | 2016 | 26818668 |
| microbial transformations of selenium species of relevance to bioremediation. | selenium species, particularly the oxyanions selenite (seo3 (2-)) and selenate (seo4 (2-)), are significant pollutants in the environment that leach from rocks and are released by anthropogenic activities. selenium is also an essential micronutrient for organisms across the tree of life, including microorganisms and human beings, particularly because of its presence in the 21st genetically encoded amino acid, selenocysteine. environmental microorganisms are known to be capable of a range of tran ... | 2016 | 27260359 |
| whole-transcriptome analysis of verocytotoxigenic escherichia coli o157:h7 (sakai) suggests plant-species-specific metabolic responses on exposure to spinach and lettuce extracts. | verocytotoxigenic escherichia coli (vtec) can contaminate crop plants, potentially using them as secondary hosts, which can lead to food-borne infection. currently, little is known about the influence of the specific plant species on the success of bacterial colonization. as such, we compared the ability of the vtec strain, e. coli o157:h7 'sakai,' to colonize the roots and leaves of four leafy vegetables: spinach (spinacia oleracea), lettuce (lactuca sativa), vining green pea (pisum sativum), a ... | 2016 | 27462311 |
| isolation of bdellovibrio sp. from soil samples in mexico and their potential applications in control of pathogens. | in this study, two strains of bdellovibrio were isolated from soil samples using the culture-dependent technique and two members of the family enterobacteriaceae (klebsiella sp. and salmonella sp.) as prey. the bdellovibrio strains were bacteriolytic, plaque-forming, and highly motile gram-negative bacteria. we identified and confirmed the bdellovibrio strains using microscopy, pcr amplification, and sequencing of the 16s rrna gene. they were observed to be different strains based on hit locus a ... | 2016 | 27297185 |
| analysis for the presence of determinants involved in the transport of mercury across bacterial membrane from polluted water bodies of india. | mercury, which is ubiquitous and recalcitrant to biodegradation processes, threatens human health by escaping to the environment via various natural and anthropogenic activities. non-biodegradability of mercury pollutants has necessitated the development and implementation of economic alternatives with promising potential to remove metals from the environment. enhancement of microbial based remediation strategies through genetic engineering approaches provides one such alternative with a promisi ... | 2016 | 26887227 |
| comparative metabolic state of microflora on the surface of the anode electrode in a microbial fuel cell operated at different ph conditions. | the metabolic state of microflora (mixed microbial cultures) in microbial fuel cells (mfcs) is currently unclear. metabolomic analyses were conducted of microflora growing on the anodic electrodes of mfcs operated at ph 7.0, 5.5, or 4.0 and utilizing starch as the major carbon substrate. a much higher current was produced at ph 7.0 than at ph 5.5 and 4.0, correlating with an increased population ratio of geobacter species to the total bacteria growing on the electrode. most intracellular metabol ... | 2016 | 28000139 |
| species diversity of environmental gim-1-producing bacteria collected during a long-term outbreak. | reports of outbreaks concerning carbapenemase-producing gram-negative bacteria in which the main source of transmission is the hospital environment are increasing. this study describes the results of environmental sampling in a protracted polyspecies metallo-beta-lactamase gim-1 outbreak driven by plasmids and bacterial clones of enterobacter cloacae and pseudomonas aeruginosa in a tertiary care center. environmental sampling targeting wet locations (especially sinks) was carried out on a surgic ... | 2016 | 27060121 |
| piperacillin concentration in relation to therapeutic range in critically ill patients--a prospective observational study. | piperacillin levels after standard dosing have been shown frequently to be subtherapeutic, especially when renal clearance was augmented. here, we aimed to determine if piperacillin was in its therapeutic range in a typically heterogeneous intensive care unit patient group, and also to describe target attainment dependent on daily dosage, creatinine clearance, and renal replacement therapy (rrt). | 2016 | 27039986 |
| triton hodge test: improved protocol for modified hodge test for enhanced detection of ndm and other carbapenemase producers. | accurate detection of carbapenemase-producing gram-negative bacilli is of utmost importance for the control of nosocomial spread and the initiation of appropriate antimicrobial therapy. the modified hodge test (mht), a carbapenem inactivation assay, has shown poor sensitivity in detecting the worldwide spread of new delhi metallo-β-lactamase (ndm). recent studies demonstrated that ndm is a lipoprotein anchored to the outer membrane in gram-negative bacteria, unlike all other known carbapenemases ... | 2016 | 26719442 |
| structural dynamics of a methionine γ-lyase for calicheamicin biosynthesis: rotation of the conserved tyrosine stacking with pyridoxal phosphate. | cale6 from micromonospora echinospora is a (pyridoxal 5' phosphate) plp-dependent methionine γ-lyase involved in the biosynthesis of calicheamicins. we report the crystal structure of a cale6 2-(n-morpholino)ethanesulfonic acid complex showing ligand-induced rotation of tyr100, which stacks with plp, resembling the corresponding tyrosine rotation of true catalytic intermediates of cale6 homologs. elastic network modeling and crystallographic ensemble refinement reveal mobility of the n-terminal ... | 2016 | 27191010 |
| the genetic analysis of an acinetobacter johnsonii clinical strain evidenced the presence of horizontal genetic transfer. | acinetobacter johnsonii rarely causes human infections. while most a. johnsonii isolates are susceptible to virtually all antibiotics, strains harboring a variety of β-lactamases have recently been described. an a. johnsonii aj2199 clinical strain recovered from a hospital in buenos aires produces per-2 and oxa-58. we decided to delve into its genome by obtaining the whole genome sequence of the aj2199 strain. genome comparison studies on aj2199 revealed 240 unique genes and a close relation to ... | 2016 | 27548264 |
| osmoadaptative strategy and its molecular signature in obligately halophilic heterotrophic protists. | halophilic microbes living in hypersaline environments must counteract the detrimental effects of low water activity and salt interference. some halophilic prokaryotes equilibrate their intracellular osmotic strength with the extracellular milieu by importing inorganic solutes, mainly potassium. these "salt-in" organisms characteristically have proteins that are highly enriched with acidic and hydrophilic residues. in contrast, "salt-out" halophiles accumulate large amounts of organic solutes li ... | 2016 | 27412608 |
| fungal peritonitis: underestimated disease in critically ill patients with liver cirrhosis and spontaneous peritonitis. | spontaneous peritonitis, especially spontaneous fungal peritonitis (sfp), is an important and potentially fatal complication in patients with endstage liver disaese. we evaluated potential risk factors, microbiological findings, and outcome of patients with sfp compared to spontaneous bacterial peritonitis (sbp) in critically ill patients. | 2016 | 27390856 |
| epidemiology and resistance patterns of bacterial and fungal colonization of biliary plastic stents: a prospective cohort study. | plastic stents used for the treatment of biliary obstruction will become occluded over time due to microbial colonization and formation of biofilms. treatment of stent-associated cholangitis is often not effective because of inappropriate use of antimicrobial agents or antimicrobial resistance. we aimed to assess the current bacterial and fungal etiology of stent-associated biofilms, with particular emphasis on antimicrobial resistance. | 2016 | 27171497 |
| depth and well type related to groundwater microbiological contamination. | use of groundwater from private wells in households has increased considerably, owing to a better cost/benefit ratio than that of water provided by local utilities for a fee. however, this water is usually untreated, which makes it a vehicle for diseases. thus, monitoring this water is necessary to ensure its integrity and quality. we aimed to evaluate the physical, chemical, and microbiological parameters of untreated groundwater drawn from different types of wells, and the antimicrobial suscep ... | 2016 | 27775681 |
| cloning, expression, and characterization of a peptidoglycan hydrolase from the burkholderia pseudomallei phage st79. | the lytic phage st79 of burkholderia pseudomallei can lyse a broad range of its host including antibiotic resistant isolates from within using a set of proteins, holin, lysb, lysc and endolysin, a peptidoglycan (pg) hydrolase enzyme. the phage st79 endolysin gene identified as peptidase m15a was cloned, expressed and purified to evaluate its potential to lyse pathogenic bacteria. the molecular size of the purified enzyme is approximately 18 kda and the in silico study cited here indicated the pr ... | 2016 | 27637947 |
| architecture of class 1, 2, and 3 integrons from gram negative bacteria recovered among fruits and vegetables. | the spread of antibiotic resistant bacteria throughout the food chain constitutes a public health concern. to understand the contribution of fresh produce in shaping antibiotic resistance bacteria and integron prevalence in the food chain, 333 antibiotic resistance gram negative isolates were collected from organic and conventionally produced fruits (pears, apples, and strawberries) and vegetables (lettuces, tomatoes, and carrots). although low levels of resistance have been detected, the bacter ... | 2016 | 27679611 |
| occurrence and antimicrobial susceptibility of enteric rods and pseudomonads isolated from the dental prostheses biofilm. | to determine the occurrence and the in vitro antimicrobial susceptibility of enteric rods and pseudomonads from the denture biofilm of 52 subjects at the center for dental specialties of sobral/ ceara, brazil. | 2016 | 27812616 |
| identification of klebsiella pneumoniae carbapenemase-producing klebsiella oxytoca in clinical isolates in tehran hospitals, iran by chromogenic medium and molecular methods. | production of carbapenemase, especially klebsiella pneumoniae carbapenemases (kpc), is one of the antibiotic resistance mechanisms of enterobacteriaceae such as klebsiella oxytoca. this study aimed to investigate and identify kpc-producing k. oxytoca isolates using molecular and phenotypic methods. | 2016 | 27812488 |
| recent advances on multi-parameter flow cytometry to characterize antimicrobial treatments. | the investigation on antimicrobial mechanisms is a challenging and crucial issue in the fields of food or clinical microbiology, as it constitutes a prerequisite to the development of new antimicrobial processes or compounds, as well as to anticipate phenomenon of microbial resistance. nowadays it is accepted that a cells population exposed to a stress can cause the appearance of different cell populations and in particular sub-lethally compromised cells which could be defined as viable but non- ... | 2016 | 27551279 |
| the importance of integrons for development and propagation of resistance in shigella: the case of latin america. | in latin america, the disease burden of shigellosis is found to coexist with the rapid and rampant spread of resistance to commonly used antibiotics. the molecular basis of antibiotic resistance lies within genetic elements such as plasmids, transposons, integrons, genomic islands, etc., which are found in the bacterial genome. integrons are known to acquire, exchange, and express genes within gene cassettes and it is hypothesized that they play a significant role in the transmission of multidru ... | 2016 | 27528086 |
| disk carbapenemase test for the rapid detection of kpc-, ndm-, and other metallo-β-lactamase-producing gram-negative bacilli. | rapid detection of carbapenemase-producing gram-negative bacilli (gnb) is required for optimal treatment of infected patients. we developed and assessed a new disk carbapenemase test (dct). | 2016 | 27374708 |
| phosphorus mobilizing consortium mammoth p(™) enhances plant growth. | phosphorus (p) is a critical nutrient used to maximize plant growth and yield. current agriculture management practices commonly experience low plant p use efficiency due to natural chemical sorption and transformations when p fertilizer is applied to soils. a perplexing challenge facing agriculture production is finding sustainable solutions to deliver p more efficiently to plants. using prescribed applications of specific soil microbial assemblages to mobilize soil bound-p to improve crop nutr ... | 2016 | 27326379 |
| evaluation of heavy metal removal from wastewater in a modified packed bed biofilm reactor. | for the effective application of a modified packed bed biofilm reactor (pbbr) in wastewater industrial practice, it is essential to distinguish the tolerance of the system for heavy metals removal. the industrial contamination of wastewater from various sources (e.g. zn, cu, cd and ni) was studied to assess the impacts on a pbbr. this biological system was examined by evaluating the tolerance of different strengths of composite heavy metals at the optimum hydraulic retention time (hrt) of 2 hour ... | 2016 | 27186636 |
| different inocula produce distinctive microbial consortia with similar lignocellulose degradation capacity. | despite multiple research efforts, the current strategies for exploitation of lignocellulosic plant matter are still far from optimal, being hampered mostly by the difficulty of degrading the recalcitrant parts. an interesting approach is to use lignocellulose-degrading microbial communities by using different environmental sources of microbial inocula. however, it remains unclear whether the inoculum source matters for the degradation process. here, we addressed this question by verifying the l ... | 2016 | 27170322 |
| clinical usefulness of arbekacin. | arbekacin is a broad-spectrum aminoglycoside used to treat methicillin-resistant staphylococcus aureus (mrsa). arbekacin has antibacterial activities against high-level gentamicin-resistant enterococci, multidrug-resistant pseudomonas aeruginosa, and acinetobacter baumannii et al. here, we reviewed in vitro data on arbekacin in staphylococci and gram-negative microorganisms. we also reviewed clinical studies for clinical efficacy and microbiologic efficacy data in patients with identified mrsa a ... | 2016 | 27104010 |
| epidemiologic and genotypic review of carbapenemase-producing organisms in british columbia, canada, between 2008 and 2014. | carbapenemase-producing organisms (cpos) are a serious emerging problem for health care facilities worldwide. owing to their resistance to most antimicrobial therapies, cpos are difficult to treat and pose a challenge for infection prevention and control. since 2010, lab-based surveillance for cpos and pcr-based testing were implemented in british columbia (bc), canada. a review of cpos in bc from 2008 to march 2014 was done to characterize the resistance mechanisms and possible clonal strain tr ... | 2016 | 26607987 |
| a multi-substrate approach for functional metagenomics-based screening for (hemi)cellulases in two wheat straw-degrading microbial consortia unveils novel thermoalkaliphilic enzymes. | functional metagenomics is a promising strategy for the exploration of the biocatalytic potential of microbiomes in order to uncover novel enzymes for industrial processes (e.g. biorefining or bleaching pulp). most current methodologies used to screen for enzymes involved in plant biomass degradation are based on the use of single substrates. moreover, highly diverse environments are used as metagenomic sources. however, such methods suffer from low hit rates of positive clones and hence the dis ... | 2016 | 26822785 |
| risk factors for bacteremia in patients with urinary catheter-associated bacteriuria. | catheter-associated bacteriuria is complicated by secondary bacteremia in 0.4% to 4.0% of cases. the directly attributable mortality rate is 12.7%. | 2016 | 27965229 |
| microbiome analysis reveals the abundance of bacterial pathogens in rousettus leschenaultii guano. | bats are crucial for proper functioning of an ecosystem. they provide various important services to ecosystem and environment. while, bats are well-known carrier of pathogenic viruses, their possible role as a potential carrier of pathogenic bacteria is under-explored. here, using culture-based approach, employing multiple bacteriological media, over thousand bacteria were cultivated and identified from rousettus leschenaultii (a frugivorous bat species), the majority of which were from the fami ... | 2016 | 27845426 |
| detection of ampc β-lactamase producing bacteria isolated in neonatal sepsis. | the objective of this study was to determine the occurrence and antimicrobial profile of ampc β-lactamase producing bacteria. | 2016 | 28083055 |
| genome sequences of nine gram-negative vaginal bacterial isolates. | the vagina is home to a wide variety of bacteria that have great potential to impact human health. here, we announce reference strains (now available through bei resources) and draft genome sequences for 9 gram-negative vaginal isolates from the taxa citrobacter, klebsiella, fusobacterium, proteus, and prevotella. | 2016 | 27688330 |
| correction: clinical impact of maldi-tof ms identification and rapid susceptibility testing on adequate antimicrobial treatment in sepsis with positive blood cultures. | [this corrects the article doi: 10.1371/journal.pone.0156299.]. | 2016 | 27658295 |
| carbapenem-resistant enterobacteriaceae: prevalence and risk factors in a single community-based hospital in korea. | carbapenemase-producing enterobacteriaceae (cpe) are gram-negative bacteria with increasing prevalence of infection worldwide. in korea, 25 cases of cpe isolates were reported by the korea centers for disease control and prevention in 2011. most cpe cases were detected mainly at tertiary referral hospitals. we analyzed the prevalence and risk factors for carbapenem-resistant enterobacteriaceae (cre) in a mid-sized community-based hospital in korea. | 2016 | 27659436 |
| a review of shv extended-spectrum β-lactamases: neglected yet ubiquitous. | β-lactamases are the primary cause of resistance to β-lactams among members of the family enterobacteriaceae. shv enzymes have emerged in enterobacteriaceae causing infections in health care in the last decades of the twentieth century, and they are now observed in isolates in different epidemiological settings both in human, animal and the environment. likely originated from a chromosomal penicillinase of klebsiella pneumoniae, shv β-lactamases currently encompass a large number of allelic vari ... | 2016 | 27656166 |
| assessment of the effectiveness of three different cephalosporins/clavulanate combinations for the phenotypic confirmation of extended spectrum beta lactamases producer bacterial isolates from urine samples at national public health laboratory, kathmandu, nepal. | the extended-spectrum β-lactamase (esbl) producing bacteria are present as the serious public health problems due to their resistance to large number of antibiotics. the main aims of this study were to determine the prevalence and antibiotic resistance patterns of bacteria producing extended-spectrum β-lactamases (esbls) and to find the suitable cephalosporin/clavulanate combination for phenotypic confirmation of esbl production. | 2016 | 27488224 |
| isolation and characterization of escherichia coli sequence type 131 and other antimicrobial-resistant gram-negative bacilli from clinical stool samples from veterans. | emerging multidrug-resistant (mdr) gram-negative bacilli (gnb), including escherichia coli sequence type 131 (st131) and its resistance-associated h30 subclone, constitute an ever-growing public health threat. their reservoirs and transmission pathways are incompletely defined. to assess diarrheal stools as a potential reservoir for st131-h30 and other mdr gnb, we cultured 100 clinical stool samples from a veterans affairs medical center clinical laboratory (october to december 2011) for fluoroq ... | 2016 | 27185805 |
| global dissemination of blakpc into bacterial species beyond klebsiella pneumoniae and in vitro susceptibility to ceftazidime-avibactam and aztreonam-avibactam. | the klebsiella pneumoniae carbapenemase (kpc), first described in the united states in 1996, is now a widespread global problem in several gram-negative species. a worldwide surveillance study collected gram-negative pathogens from 202 global sites in 40 countries during 2012 to 2014 and determined susceptibility to β-lactams and other class agents by broth microdilution testing. molecular mechanisms of β-lactam resistance among carbapenem-nonsusceptible enterobacteriaceae and pseudomonas aerugi ... | 2016 | 27161636 |
| comparative study of cronobacter identification according to phenotyping methods. | microbiological criteria applied to powdered infant formula (pif) require the absence of all cronobacter spp. consequently, misidentification of isolates from finished products can lead to significant financial losses for manufacturers and could increase the risk of neonatal infection. biochemical identification of suspect isolates using commercially available test panels is recommended for use by pif manufacturers by both the us fda and iso standard methods for cronobacter species; however, phe ... | 2016 | 27401027 |
| development of a phage cocktail to control proteus mirabilis catheter-associated urinary tract infections. | proteus mirabilis is an enterobacterium that causes catheter-associated urinary tract infections (cautis) due to its ability to colonize and form crystalline biofilms on the catheters surface. cautis are very difficult to treat, since biofilm structures are highly tolerant to antibiotics. phages have been used widely to control a diversity of bacterial species, however, a limited number of phages for p. mirabilis have been isolated and studied. here we report the isolation of two novel virulent ... | 2016 | 27446059 |
| antimicrobial activities of ceftazidime-avibactam and comparator agents against gram-negative organisms isolated from patients with urinary tract infections in u.s. medical centers, 2012 to 2014. | a total of 7,272 unique patient clinical isolates were collected from 71 u.s. medical centers from patients with urinary tract infections in 2012 to 2014 and tested for susceptibility to ceftazidime-avibactam and comparators by broth microdilution methods. ceftazidime-avibactam inhibited >99.9% of all enterobacteriaceae at the susceptible breakpoint of ≤8 μg/ml (there were only three nonsusceptible strains). ceftazidime-avibactam was also active against pseudomonas aeruginosa isolates (mic50, 2 ... | 2016 | 27114273 |
| clinical impact of maldi-tof ms identification and rapid susceptibility testing on adequate antimicrobial treatment in sepsis with positive blood cultures. | shortening the turn-around time (tat) of positive blood culture (bc) identification (id) and susceptibility results is essential to optimize antimicrobial treatment in patients with sepsis. we aimed to evaluate the impact on antimicrobial prescription of a modified workflow of positive bcs providing id and partial susceptibility results for enterobacteriaceae (eb), pseudomonas aeruginosa and staphylococcus aureus on the day of bc positivity detection. this study was divided into a pre-interventi ... | 2016 | 27228001 |
| vector potential of blattella germanica (l.) (dictyoptera: blattidae) for medically important bacteria at food handling establishments in jimma town, southwest ethiopia. | cockroaches have been regarded as possible vectors of human enteropathogens. their presence and crawl particularly in food handling establishments could be risky for human health. therefore, this study was done to determine the vector potential of cockroach for medically important bacterial pathogens in restaurants and cafeterias. a cross-sectional study was conducted on cockroaches from restaurants and cafeterias in jimma town from may to september 2014. standard taxonomic keys and microbiologi ... | 2016 | 27294115 |
| in vitro susceptibility to ceftazidime-avibactam of carbapenem-nonsusceptible enterobacteriaceae isolates collected during the inform global surveillance study (2012 to 2014). | the activity of ceftazidime-avibactam was assessed against 961 isolates of meropenem-nonsusceptible enterobacteriaceae most meropenem-nonsusceptible metallo-β-lactamase (mbl)-negative isolates (97.7%) were susceptible to ceftazidime-avibactam. isolates that carried kpc or oxa-48-like β-lactamases, both alone and in combination with extended-spectrum β-lactamases (esbls) and/or ampc β-lactamases, were 98.7% and 98.5% susceptible to ceftazidime-avibactam, respectively. meropenem-nonsusceptible, ca ... | 2016 | 26926648 |
| antimicrobial activities of ceftaroline and comparator agents against bacterial organisms causing bacteremia in patients with skin and skin structure infections in u.s. medical centers, 2008 to 2014. | we evaluated the antimicrobial susceptibility of 1,454 organisms consecutively collected from patients with bacteremia associated with skin and skin structure infections. the most common organisms obtained werestaphylococcus aureus(670 organisms [46.1%]),escherichia coli(200 organisms [13.8%]), β-hemolytic streptococci (βhs) (138 organisms [9.5%]), andklebsiella pneumoniae(109 organisms [7.5%]). the susceptibility rates for ceftaroline were 97.9% fors. aureus(95.9% among methicillin-resistants. ... | 2016 | 26856825 |
| insights into newer antimicrobial agents against gram-negative bacteria. | currently, drug resistance, especially against cephalosporins and carbapenems, among gram-negative bacteria is an important challenge, which is further enhanced by the limited availability of drugs against these bugs. there are certain antibiotics (colistin, fosfomycin, temocillin, and rifampicin) that have been revived from the past to tackle the menace of superbugs, including members of enterobacteriaceae, acinetobacter species, and pseudomonas species. very few newer antibiotics have been add ... | 2016 | 27013887 |
| evaluation of the septifast mgrade test on standard care wards--a cohort study. | the immediate need for appropriate antimicrobial therapy in septic patients requires the detection of the causative pathogen in a timely and reliable manner. in this study, the real-time pcr septifast mgrade test was evaluated in adult patients meeting the systemic inflammatory response syndrome (sirs) criteria that were treated at standard care wards. | 2016 | 26986826 |
| β-lactamase characterization of gram-negative pathogens recovered from patients enrolled in the phase 2 trials for ceftazidime-avibactam: clinical efficacies analyzed against subsets of molecularly characterized isolates. | the correlation of the clinical efficacies of ceftazidime-avibactam and comparators (carbapenems) was evaluated against baseline gram-negative isolates having characterized β-lactam resistance mechanisms from complicated urinary tract infection (cuti) and complicated intra-abdominal infection (ciai) phase 2 trials. enterobacteriaceae displaying ceftriaxone and/or ceftazidime mics of ≥ 2 μg/ml (69 isolates) and nonfermentative gram-negative bacilli (nf-gnb [three isolates]) with ceftazidime mics ... | 2016 | 26666936 |
| correlation of β-lactamase production and colistin resistance among enterobacteriaceae isolates from a global surveillance program. | the increasing use of carbapenems for treating multidrug-resistant (mdr) gram-negative bacterial infections has contributed to the global dissemination of carbapenem-resistant enterobacteriaceae (cre). serine and metallo-β-lactamases (mbls) that hydrolyze carbapenems have become prevalent and endemic in some countries, necessitating the use of older classes of agents, such as colistin. a total of 19,719 isolates of enterobacteriaceae (excluding proteeae and serratia spp., which have innate resis ... | 2016 | 26666920 |