Publications

chronic inflammation and oxidative stress: the smoking gun for helicobacter pylori-induced gastric cancer?	helicobacter pylori is the leading risk factor associated with gastric carcinogenesis. h. pylori leads to chronic inflammation because of the failure of the host to eradicate the infection. chronic inflammation leads to oxidative stress, deriving from immune cells and from within gastric epithelial cells. this is a main contributor to dna damage, apoptosis and neoplastic transformation. both pathogen and host factors directly contribute to oxidative stress, including h. pylori virulence factors, ...	2017	23811829
current recommendations for helicobacter pylori therapies in a world of evolving resistance.	occurrence of resistance, especially to clarithromycin, renders the standard triple therapy used to cure helicobacter pylori infection ineffective. this review presents the bacteriological and pharmacological basis for h. pylori therapy and the current recommendations. the third-line treatment must be based on clarithromycin susceptibility testing. if the bacteria are still susceptible, failure may come from problems of compliance, hyperacidity or high bacterial load which can be overcome. if th ...	2017	23929066
helicobacter pylori infection does not promote hepatocellular cancer in a transgenic mouse model of hepatitis c virus pathogenesis.	helicobacter pylori (h. pylori) and hepatitis c virus (hcv) infect millions of people and can induce cancer. we investigated if h. pylori infection promoted hcv-associated liver cancer. helicobacter-free c3b6f1 wild-type (wt) and c3b6f1-tg(alb1-hcvn)35sml (ht) male and female mice were orally inoculated with h. pylori ss1 or sterile media. mice were euthanized at ~12 mo postinoculation and samples were collected for analyses. there were no significant differences in hepatocellular tumor promotio ...	2017	23929035
modeling temporal relationships in large scale clinical associations.	we describe an approach for modeling temporal relationships in a large scale association analysis of electronic health record data. the addition of temporal information can inform hypothesis generation and help to explain the relationships. we applied this approach on a dataset containing 41.2 million time-stamped international classification of diseases, ninth revision (icd-9) codes from 1.6 million patients.	2017	23019240
chronic idiophatic urticaria and helicobacter pylori: a specific pattern of gastritis and urticaria remission after helicobacter pylori eradication.	chronic urticaria (cu) is defined as the occurrence of spontaneous wheals for a duration of more than 6 weeks and is the most frequent skin disease, with prevalence ranging between 15 and 25%, and is a seriously disabling condition, with social isolation and mood changes causing a significant degree of dysfunction and quality of life impairment to many patients. the main clinical features of cu are the repeated occurrence of transient eruptions of pruritic wheals or patchy erythema on the skin t ...	2017	23058028
par1b takes the stage in the morphogenetic and motogenetic activity of helicobacter pylori caga oncoprotein.	helicobacter pylori caga oncoprotein is critically involved in gastric carcinogenesis. upon delivery into gastric epithelial cells via type iv secretion, caga induces an extremely elongated cell-shape known as the hummingbird phenotype, which is associated with massive changes in actin cytoskeleton and elevated motility. with the notion that the hummingbird phenotype reflects pathogenic/oncogenic activity of caga, many studies have focused on the mechanism through which caga induces the morpholo ...	2017	23076215
correlation of serology with morphological changes in gastric biopsy in helicobacter pylori infection and evaluation of immunohistochemistry for h. pylori identification.	helicobacter pylori is implicated in various gastroduodenal diseases and many tests are available for its detection. the present study attempted to document the morphological changes in the gastric mucosa induced by h. pylori colonization and correlate them with the severity of the infection. the study also compared various diagnostic tests and evaluated the different staining methods used for h. pylori detection, especially immunohistochemical identification.	2017	23150022
optimization of culture conditions to improve helicobacter pylori growth in ham's f-12 medium by response surface methodology.	helicobacter pylori is a gastroduodenal pathogen that colonizes the human stomach and is the causal agent of gastric diseases. from the clinical and epidemiological point of view, enhancing and improving the growth of this bacterium in liquid media is an important goal to achieve in order to allow the performance of accurate physiological studies. the aim of this work was to optimize three culture conditions that influence the growth of h. pylori in the defined medium ham s f-12 supplemented wit ...	2017	23298481