Publications

furazolidone-based therapies for helicobacter pylori infection: a pooled-data analysis.	furazolidone-based therapies are used in developing countries to cure helicobacter pylori infection due to its low cost. the low bacterial resistance toward furazolidone may render appealing the use of this drug even in developed countries. however, some relevant safety concerns do exist in using furazolidone.	2017	22249086
polymorphism in the helicobacter pylori caga and vaca toxins and disease.	half of the world's population is infected with helicobacter pylori and approximately 20% of infected individuals develop overt clinical disease such as ulcers and stomach cancer. paradoxically, despite its classification as a class i carcinogen, h. pylori has been shown to be protective against development of asthma, allergy, and esophageal disease. given these conflicting roles for h. pylori, researchers are attempting to define the environmental, host, and pathogen interactions that ultimatel ...	2017	23380646
optimization of culture conditions to improve helicobacter pylori growth in ham's f-12 medium by response surface methodology.	helicobacter pylori is a gastroduodenal pathogen that colonizes the human stomach and is the causal agent of gastric diseases. from the clinical and epidemiological point of view, enhancing and improving the growth of this bacterium in liquid media is an important goal to achieve in order to allow the performance of accurate physiological studies. the aim of this work was to optimize three culture conditions that influence the growth of h. pylori in the defined medium ham s f-12 supplemented wit ...	2017	23298481
study of the cytoxin-associated gene a (caga gene) in helicobacter pylori using gastric biopsies of iraqi patients.	the helicobacter pylori caga gene is a major virulence factor that plays an important role in gastric pathologies. the size variation of caga gene, which is dependent on the 3' repeat region, contains one or more glu-pro-ile-tyr-ala (epiya) motifs and caga multimerization (cm) motifs. four segments flanking the epiya motifs, epiya -a, -b, -c, or -d, were reported to play a crucial role in the pathogenesis of h. pylori infection. the aim was to determine the roles of epiya segments and cm motifs ...	2017	23481132
par1b takes the stage in the morphogenetic and motogenetic activity of helicobacter pylori caga oncoprotein.	helicobacter pylori caga oncoprotein is critically involved in gastric carcinogenesis. upon delivery into gastric epithelial cells via type iv secretion, caga induces an extremely elongated cell-shape known as the hummingbird phenotype, which is associated with massive changes in actin cytoskeleton and elevated motility. with the notion that the hummingbird phenotype reflects pathogenic/oncogenic activity of caga, many studies have focused on the mechanism through which caga induces the morpholo ...	2017	23076215
chronic idiophatic urticaria and helicobacter pylori: a specific pattern of gastritis and urticaria remission after helicobacter pylori eradication.	chronic urticaria (cu) is defined as the occurrence of spontaneous wheals for a duration of more than 6 weeks and is the most frequent skin disease, with prevalence ranging between 15 and 25%, and is a seriously disabling condition, with social isolation and mood changes causing a significant degree of dysfunction and quality of life impairment to many patients. the main clinical features of cu are the repeated occurrence of transient eruptions of pruritic wheals or patchy erythema on the skin t ...	2017	23058028
correlation of serology with morphological changes in gastric biopsy in helicobacter pylori infection and evaluation of immunohistochemistry for h. pylori identification.	helicobacter pylori is implicated in various gastroduodenal diseases and many tests are available for its detection. the present study attempted to document the morphological changes in the gastric mucosa induced by h. pylori colonization and correlate them with the severity of the infection. the study also compared various diagnostic tests and evaluated the different staining methods used for h. pylori detection, especially immunohistochemical identification.	2017	23150022
modeling temporal relationships in large scale clinical associations.	we describe an approach for modeling temporal relationships in a large scale association analysis of electronic health record data. the addition of temporal information can inform hypothesis generation and help to explain the relationships. we applied this approach on a dataset containing 41.2 million time-stamped international classification of diseases, ninth revision (icd-9) codes from 1.6 million patients.	2017	23019240