Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| acute chlamydia pneumoniae reinfection accelerates the development of insulin resistance and diabetes in obese c57bl/6 mice. | epidemiological and pathological evidence links highly prevalent pathogens to chronic inflammatory diseases, such as type 2 diabetes. animal models contribute critically to the mechanistic understanding of infectious enhancement of inflammatory diseases, which share insulin resistance as the central pathophysiological defect. | 2009 | 19508161 |
| [atypical and opportunistic pulmonary infections after cardiac surgery]. | new diseases and therapies that lead to marked immunocompromise, have brought to medicine so-called opportunistic infections, caused by pathogens that usually do not cause disease in the presence of a healthy immune system. first diagnosed in aids patients, opportunistic infections have appeared in many other situations, including transplant recipients, other immunosuppressed patients, and even in otherwise healthy patients undergoing major elective surgery. among the most common pathogens causi ... | 2009 | 19517677 |
| effects of cd14, tlr2, tlr4, lpb, and il-6 gene polymorphisms on chlamydia pneumoniae growth in human macrophages in vitro. | chlamydia pneumoniae is an obligate intracellular gram-negative bacterium, which causes respiratory infections in humans. it can infect various cell types, e.g. vascular endothelial cells, smooth muscle cells and monocyte-derived macrophages in vitro. the susceptibility of macrophages from healthy individuals to c. pneumoniae infection is highly variable. in this study, we evaluated the effects of innate immunity genes cd14 -260 c>t, tlr2 arg753gln, tlr4 asp299gly, lbp phe436leu and il6 -174 g>c ... | 2009 | 19522765 |
| [intervention of huanglian jiedu decoction on haemorheology and cholesterol-supplemented diet]. | to study the influence of chlamydia pneumonia (cpn) infection on haemorheology and atherosclerosis and the intervention of huanglian jiedu decoction (hjt). | 2009 | 19526793 |
| prevalence of chlamydophila psittaci infections in a human population in contact with domestic and companion birds. | chlamydophila psittaci infections in humans are underestimated. we investigated the occurrence of c. psittaci in a belgian population of 540 individuals. data were from a population survey (n=2524) of apparently healthy community-dwelling subjects aged 35-55 years. pharyngeal swabs and blood were taken. individuals completed a questionnaire on professional and nonprofessional activities, smoking habits, medical history and contact frequency with different bird species. swabs were analysed by a c ... | 2009 | 19528151 |
| relevance of the genetic polymorphism of nod1 in chlamydia pneumoniae seropositive stroke patients. | chronic infections with certain pathogens, such as chlamydia pneumoniae, and genetic parameters that influence inflammatory reactions have been suggested to contribute to ischaemic stroke. nod1 is a potent cytosolic receptor for c. pneumoniae. the aim of this study was to investigate the genetic polymorphism of nod1 from the aspect of the development of stroke. | 2009 | 19538217 |
| chlamydia pneumoniae hides inside apoptotic neutrophils to silently infect and propagate in macrophages. | intracellular pathogens have developed elaborate strategies for silent infection of preferred host cells. chlamydia pneumoniae is a common pathogen in acute infections of the respiratory tract (e.g. pneumonia) and associated with chronic lung sequelae in adults and children. within the lung, alveolar macrophages and polymorph nuclear neutrophils (pmn) are the first line of defense against bacteria, but also preferred host phagocytes of chlamydiae. | 2009 | 19547701 |
| alzheimer's disease and infection: do infectious agents contribute to progression of alzheimer's disease? | infection with several important pathogens could constitute risk factors for cognitive impairment, dementia, and alzheimer's disease (ad) in particular. this review summarizes the data related to infectious agents that appear to have a relationship with ad. infections with herpes simplex virus type 1, picornavirus, borna disease virus, chlamydia pneumoniae, helicobacter pylori, and spirochete were reported to contribute to the pathophysiology of ad or to cognitive changes. based on these reports ... | 2009 | 19560105 |
| clarithromycin suppresses airway hyperresponsiveness and inflammation in mouse models of asthma. | macrolide antibiotics, a class of potent antimicrobials, also possess immunomodulatory/anti-inflammatory properties. these properties are considered fundamental for the efficacy of macrolide antibiotics in the treatment of diffuse panbronchiolitis and cystic fibrosis. in patients with asthma, macrolide antibiotics have been reported to reduce airway hyperresponsiveness and improve pulmonary function. however, their beneficial actions in asthmatics possibly could be attributed to antimicrobial ac ... | 2009 | 19560456 |
| asthma, bronchial hyper-responsiveness and chlamydophila (chlamydia) pneumonia infection in adult thai population. | the associations between chlamydophila (chlamydia) pneumonia infection and chronic asthma or bronchial hyper-responsiveness (bhr) have been inconclusive. | 2009 | 19562983 |
| the effect of azithromycin and chlamydophilia pneumonia infection on expansion of small abdominal aortic aneurysms--a prospective randomized double-blind trial. | the aim of the study was to evaluate the effect of azithromycin on the expansion rate of small abdominal aortic aneurysms (aaas), and to determine whether or not a correlation exists between serological markers for chlamydophilia pneumonia (cpn) infection and aaa expansion. | 2009 | 19563951 |
| [comparative study of the seroprevalence of mycoplasma pneumoniae and chlamydia pneumoniae infection in the course of chronic asthma in children]. | 2009 | 19570661 | |
| [cough syncope caused by a possible chlamydia pneumoniae pneumonia]. | we report the case of a 61-year-old man who presented with coughing fits followed by sinus pauses and syncope. cardiac and neurological diagnostic work-up was negative and the patient was considered to have cough syncope. as this occurred within the context of febrile pneumonia, an infectious disease was suspected but diagnostic work-up only revealed an increase of antibodies against chlamydia pneumoniae. the responsibility of this agent is discussed. clinical recovery was obtained with the pres ... | 2009 | 19586690 |
| chlamydia pneumoniae and atherosclerosis: the role of mast cells. | chlamydia pneumoniae (c. pneumoniae), a respiratory pathogen, has been implicated in the pathogenesis of atherosclerosis, an inflammatory progressive disease, characterized by the formation of atherosclerotic plaques. among several types of inflammatory cells involved in the atherogenesis process, recently particular attention has been directed toward the mast cells. experimental studies have provided several mechanisms by which c. pneumoniae and mast cells could play a role in all stages of ath ... | 2009 | 19589286 |
| independent inactivation of arginine decarboxylase genes by nonsense and missense mutations led to pseudogene formation in chlamydia trachomatis serovar l2 and d strains. | chlamydia have reduced genomes that reflect their obligately parasitic lifestyle. despite their different tissue tropisms, chlamydial strains share a large number of common genes and have few recognized pseudogenes, indicating genomic stability. all of the chlamydiaceae have homologs of the aaxabc gene cluster that encodes a functional arginine:agmatine exchange system in chlamydia (chlamydophila)pneumoniae. however, chlamydia trachomatis serovar l2 strains have a nonsense mutation in their aaxb ... | 2009 | 19607664 |
| simultaneous use of direct and indirect diagnostic techniques in atypical respiratory infections from chlamydophila pneumoniae and mycoplasma pneumoniae. | in 2008, 50 samples (bal), coming from hospital patients, with acute respiratory symptoms have been investigated using two real-time pcr methods: one assay for the single detection of chlamydophila pneumoniae and mycoplasma pneumoniae dna and one commercially available real-time duplex pcr assay for the detection of c. pneumoniae and m. pneumoniae dna. both techniques used here showed compliant results, with 100% concordance for detection of c. pneumoniae and 98% for detection of m. pneumoniae. ... | 2009 | 19623657 |
| assay of chlamydia pneumoniae-specific igm antibodies by elisa method--reduction of non-specific reaction and resetting of serological criteria by measuring igm antibodies--. | in the present study, we tried to reduce the non-specific reactions for measuring anti-chlamydia pneumoniae igm antibodies by the elisa kit of hitazyme c. pneumoniae ab-igm (hitazyme igm) by using a new absorbent. we also tried to reset the igm cut-off index (id) of hitazyme igm by testing serum samples from healthy children and healthy adults with no respiratory symptoms. the results suggest that the use of the new absorbent (anti-human igg antibodies) may reduce the non-specific reactions by r ... | 2009 | 19628901 |
| prevalence of chlamydia pneumoniae and mycoplasma pneumoniae in different forms of coronary disease. | several infectious agents have been investigated since the association between atherosclerosis and infection was demonstrated; however, the results of these studies are contradictory. | 2009 | 19629306 |
| verification of the propneumo-1 assay for the simultaneous detection of mycoplasma pneumoniae and chlamydophila pneumoniae in clinical respiratory specimens. | mycoplasma pneumoniae and chlamydophila pneumoniae are major causes of lower and upper respiratory infections that are difficult to diagnose using conventional methods such as culture. the propneumo-1 (prodesse, waukesha, wi) assay is a commercial multiplex real-time pcr assay for the simultaneous detection of m. pneumoniae and/or c. pneumoniae dna in clinical respiratory samples. | 2009 | 19284712 |
| atypical bacterial pathogens in community-acquired pneumonia in children: a hospital-based study. | a total of 243 children aged one month to five years with world health organization defined severe community acquired pneumonia were studied for the presence of atypical bacterial pathogens: 24 were found positive for mycoplasma infection. there was no significant association with any of the clinical, laboratory and radiological variables in children with pneumonia by the atypical pathogen. | 2009 | 19299299 |
| development and evaluation of a multiplex test for the detection of atypical bacterial dna in community-acquired pneumonia during childhood. | an incorrect or late diagnosis can lead to an increase in the morbidity and mortality caused by pneumonia, and the availability of a rapid and accurate microbiological test to verify the aetiology is imperative. this study evaluated a molecular test for the identification of the bacterial cause of atypical community-acquired pneumonia (acap). fifty-four children with pneumonia were studied using bacteriological cultures, mycoplasma pneumoniae, coxiella burnetii, chlamydophila pneumoniae and legi ... | 2009 | 19302698 |
| chlamydia pneumoniae and atherosclerosis: current state and future prospectives. | chlamydia pneumoniae, an intracellular bacterial pathogen, is known as a leading cause of human respiratory tract infections worldwide. over the last decade, several reports in the literature have suggested that infection with c. pneumoniae may contribute to the pathogenesis of atherosclerosis. in order to play a causative role in chronic disease, c. pneumoniae would need to persist within infected tissue for extended periods of time, thereby stimulating a chronic inflammatory response. c. pneum ... | 2009 | 19309547 |
| infection, its treatment and the risk for stroke. | stroke is among the most common causes of death and persisting disability and therefore represents a great social and economic burden worldwide. in order to lower this burden it is essential to identify risk factors and respective preventive strategies. besides the established stroke risk factors (e.g. hypertension, diabetes, hypercholesterolemia, atrial fibrillation) both acute and chronic infectious diseases have emerged as risk factors for stroke. mainly acute respiratory tract infection but ... | 2009 | 19355997 |
| pgp3 antibody enzyme-linked immunosorbent assay, a sensitive and specific assay for seroepidemiological analysis of chlamydia trachomatis infection. | understanding of the burden of chlamydia trachomatis infection and its clinical sequelae is hampered by the absence of accurate, well-characterized tests using serological methods to determine past exposure to infection. an "in-house" immunoglobulin g (igg) enzyme-linked immunosorbent assay (elisa) based on the c. trachomatis-specific antigen pgp3 was produced and evaluated against three commercial elisas derived from the major outer membrane protein: the medac pelisa plus, the savyon seroct-igg ... | 2009 | 19357314 |
| qualitative and quantitative detection of chlamydophila pneumoniae dna in cerebrospinal fluid from multiple sclerosis patients and controls. | a standardized molecular test for the detection of chlamydophila pneumoniae dna in cerebrospinal fluid (csf) would assist the further assessment of the association of c. pneumoniae with multiple sclerosis (ms). we developed and validated a qualitative colorimetric microtiter plate-based pcr assay (pcr-eia) and a real-time quantitative pcr assay (taqman) for detection of c. pneumoniae dna in csf specimens from ms patients and controls. compared to a touchdown nested-pcr assay, the sensitivity, sp ... | 2009 | 19357786 |
| detection of antibodies to chlamydophila pneumoniae by immunoblotting in patients with cardiovascular diseases. | chlamydophila pneumoniae, one of the most prevalent human pathogens worldwide, is not only a significant cause of pneumonia, but may also be associated with cardiovascular diseases (cvd) as suggested by multiple studies. a total of 228 sera from cvd patients with hypertension, ischemic heart disease or previous reconstructive vascular surgery were screened for the presence of anti-c. pneumoniae igg and iga antibodies by elisa. out of 150 positive serum samples, 80 with similar igg and iga levels ... | 2009 | 19358448 |
| association of plasma circulatory markers, chlamydia pneumoniae, and high sensitive c-reactive protein in coronary artery disease patients of india. | plasma inflammatory markers have been shown to be predictors for cardiovascular risk, however, there is no study where the levels of plasma circulatory markers have been evaluated in coronary artery disease patients (cad pts) positive for c. pneumoniae iga and high sensitive c-reactive protein (hscrp) which may help in better understanding of disease pathogenesis. a total of 192 patients and 192 controls attending the cardiology outpatient department of safdarjung hospital were enrolled. the lev ... | 2009 | 19360108 |
| the nod/rip2 pathway is essential for host defenses against chlamydophila pneumoniae lung infection. | here we investigated the role of the nod/rip2 pathway in host responses to chlamydophila pneumoniae-induced pneumonia in mice. rip2(-/-) mice infected with c. pneumoniae exhibited impaired inos expression and no production, and delayed neutrophil recruitment to the lungs. levels of il-6 and ifn-gamma levels as well as kc and mip-2 levels in bronchoalveolar lavage fluid (balf) were significantly decreased in rip2(-/-) mice compared to wild-type (wt) mice at day 3. rip2(-/-) mice showed significan ... | 2009 | 19360122 |
| high sensitivity c-reactive protein is associated with the metabolic syndrome independent to viral and bacterial pathogen burden. | to investigate the influences of bacterial or viral pathogen burden in the relationship of high sensitivity c-reactive protein (hs-crp) and the metabolic syndrome in a population-based study. | 2009 | 19362745 |
| beneficial effect of clarithromycin in patients with acute coronary syndrome and complement c4 deficiencies. | we sought to examine the role of complement component c4 deficiencies on the effect of antibiotic treatment in patients with acute coronary syndrome (acs). | 2009 | 19365786 |
| [familial predisposition and microbial etiology in dilated cardiomyopathy]. | cardiomyopathies are an important and diverse group of heart muscle diseases in which the heart muscle itself is structurally or functionally abnormal and in which coronary artery disease, hypertension, valvular and congenital heart disease are absent or do not sufficiently explain the observed myocardial abnormality. this often results in severe heart failure accompanied by arrhythmias and/or sudden death. clinical and morphological diversity of cardiomyopathies can reflect the broad spectrum o ... | 2009 | 19370326 |
| chlamydophila pneumoniae. | chlamydophila pneumoniae infection is ubiquitous. it accounts for 10% of community-acquired pneumonias and 5% of cases of pharyngitis, bronchitis and sinusitis in both immunocompetent and immunocompromised hosts. it is also involved in exacerbations of chronic bronchitis and asthma. moreover, c. pneumoniae has been reported as a possible cause of atherosclerosis and central nervous system disorders. the current reference standard for serological diagnosis of acute infection is microimmunofluores ... | 2009 | 19220337 |
| molecular pathogenesis of chronic chlamydia pneumoniae infection: a brief overview. | owing to its unique host cell-dependent development cycle, chlamydia pneumoniae occupies an intracellular niche that enables the bacterium to survive and to multiply, secluded from both the extracellular and the cytoplasmic environments. within its separate chlamydial inclusion, it is able to genetically switch between a replicative and a persisting non-replicative state, linking the pathogen to acute as well as chronic diseases. although its role in acute respiratory infection has been establis ... | 2009 | 19220338 |
| pharmacokinetics of edp-420 after ascending single oral doses in healthy adult volunteers. | edp-420 (ep-013420, s-013420) is a first-in-class bicyclolide (bridged bicyclic macrolide) currently in clinical development for the treatment of respiratory tract infections. it has good preclinical pharmacokinetic properties across multiple species and potent in vitro and in vivo activity against respiratory tract infection pathogens, including haemophilus influenzae, atypical organisms (e.g., chlamydia pneumoniae, mycoplasma pneumoniae, and legionella pneumophila), and multidrug-resistant str ... | 2009 | 19223626 |
| throat infection, neck and chest pain and cardiac response: a persistent infection-related clinical syndrome. | dizziness, chest discomfort, chest depression and dyspnea are a group of symptoms that are common complaints in clinical practice. patients with these symptoms are usually informed that while neurosis consequent to coronary heart disease is excluded nonetheless they remain unhealthy with no rational explanation or treatment. 165 cases of these symptoms and 85 control subjects were reviewed and underwent further medical history inquiry, routine ekg test and cardiac ultrasound examination. thirty- ... | 2009 | 19224156 |
| cultivation and laboratory maintenance of chlamydia pneumoniae. | chlamydiae are gram-negative obligate intracellular parasites. chlamydia pneumoniae is a human respiratory pathogen that causes pneumonia, bronchitis, sinusitis, and pharyngitis. c. pneumoniae has also been associated with cardiovascular disease. c. pneumoniae can only be grown in cell culture and is more difficult to isolate from specimens than chlamydia trachomatis. commonly used cell lines for isolation of c. trachomatis are not sensitive for c. pneumoniae. the most sensitive cell lines for i ... | 2009 | 19235146 |
| the science of selecting antimicrobials for community-acquired pneumonia (cap). | among infectious diseases, community-acquired pneumonia (cap) is the leading cause of death in the united states and is associated with a substantial economic burden to the health care system. initiating appropriate empiric therapy can be challenging given elevated resistance rates among streptococcus pneumoniae strains. | 2009 | 19236135 |
| serological evidence of infections and type 2 diabetes: the multiethnic study of atherosclerosis. | prospective studies have identified chronic inflammation as a risk factor for type 2 diabetes. however, it is not known whether infection by specific pathogens or having a greater 'pathogen burden' is associated with diabetes. the aim of this study was to examine the cross-sectional relation of seropositivity to five pathogens (chlamydia pneumoniae, cytomegalovirus, helicobacter pylori, hepatitis a virus, herpes simplex virus) and prevalent diabetes. | 2009 | 19236617 |
| etiology of community-acquired pneumonia in hospitalized children based on who clinical guidelines. | community-acquired pneumonia (cap) is a major cause of death in developing countries and of morbidity in developed countries. the objective of the study was to define the causative agents among children hospitalized for cap defined by who guidelines and to correlate etiology with clinical severity and surrogate markers. investigations included an extensive etiological workup. a potential causative agent was detected in 86% of the 99 enrolled patients, with evidence of bacterial (53%), viral (67% ... | 2009 | 19238436 |
| association between chlamydia pneumoniae igg antibodies and migraine. | in this study, there is a confirmed association between cerebral infarction with migraine and chlamydia pneumoniae infection, but the association between c. pneumoniae igg antibodies and migraine in the general population has not been investigated. c. pneumoniae igg antibody levels were compared in 329 adult chinese patients, who met the international classification of headache disorders 2nd edition (ichd ii) criteria for migraine, and in 329 healthy subjects. factors such as gender, age, smokin ... | 2009 | 19238508 |
| kdo-(2 --> 8)-kdo-(2 --> 4)-kdo but not kdo-(2 --> 4)-kdo-(2 --> 4)-kdo is an acceptor for transfer of l-glycero-alpha-d-manno-heptose by escherichia coli heptosyltransferase i (waac). | early steps in the biosynthesis of lipopolysaccharide (lps) involve the transfer of 3-deoxy-alpha-d-manno-oct-2-ulopyranosonic acid (kdo) to lipid a. whereas kdo transferases (waaa) of escherichia coli generate a (2 --> 4)-linked kdo disaccharide, chlamydiae contain tri- or tetra-functional waaa generating oligosaccharides with (2 --> 8)- and (2 --> 4)-linkages between kdo. it has been suggested that the transfer of l-glycero-alpha-d-manno-heptose (hep) to kdo by an e. coli waac may not be possi ... | 2009 | 19201821 |
| induction of interleukin-18 in atherosclerotic patients: a role for chlamydia pneumoniae. | the present work explored gene expression and spontaneous induction of the inflammatory cytokine interleukin-18 (il-18) in atherosclerotic patients. in addition, the effect of the chlamydial antigen heat shock protein 60 (hsp60) and lipopolysaccharide (lps) on the induction of this mediator was examined. | 2009 | 19204428 |
| development and evaluation of a loop-mediated isothermal amplification method for the rapid detection of chlamydophila pneumoniae. | we developed a loop-mediated isothermal amplification (lamp) method to detect chlamydophila pneumoniae infection. this assay exclusively amplified c. pneumoniae sequences and no cross-reactivity was observed for other chlamydia species. the detection limit for this assay was found to be ten elementary bodies in 25 min, as observed in a real-time turbidimeter and electrophoretic analysis. the specificity of the lamp reaction was confirmed by restriction endonuclease analysis, as well as direct se ... | 2009 | 19205763 |
| chronic and repeated chlamydophila pneumoniae lung infection can result in increasing il-4 gene expression and thickness of airway subepithelial basement membrane in mice. | chlamydophila pneumoniae infection has been associated with several pulmonary and cardiac diseases. however, it has not been explored for its ability to activate the same immunopathologic mechanisms of asthma, namely, a predominant th2 immune response and structural changes that are termed airway remodeling. this study evaluated immune responses in the lung and airway pathology of balb/c mice with chronic and repeated c. pneumoniae infections. | 2009 | 19181607 |
| detection of circulating chlamydophila pneumoniae in patients with coronary artery disease and healthy control subjects. | there is a long history of research suggesting that chlamydophila pneumoniae is associated with coronary artery disease (cad). c. pneumoniae in peripheral blood mononuclear cells (pbmcs) could serve as a risk factor for cad if respiratory infection with c. pneumoniae spreads to atherosclerotic plaques through pbmcs or if infected plaques shed c. pneumoniae-laden pbmcs into the circulation. | 2009 | 19191640 |
| host molecular defense mechanisms against chlamydophila pneumoniae and genetic studies of immune-response-related genes in asthma. | chlamydophila pneumoniae is an intracellular pathogen and a major cause of pneumonia that can cause chronic, persistent, and often asymptomatic, infections in target cells such as monocytes, macrophages, endothelial cells, fibroblasts, and smooth muscle cells. chlamydial infections play roles in new-onset wheezing, exacerbation of prevalent asthma, and long-term decrements in lung function. however, accurate standardized laboratory tests to diagnose infection with c. pneumoniae have not been est ... | 2009 | 19149742 |
| socioeconomic and psychosocial gradients in cardiovascular pathogen burden and immune response: the multi-ethnic study of atherosclerosis. | the biologic mechanisms linking socioeconomic position and psychosocial factors to cardiovascular disease (cvd) are not well understood. immune response to persistent pathogens may be one of these mechanisms. | 2009 | 19150399 |
| acute chlamydia pneumoniae infection in the pathogenesis of autoimmune diseases. | autoimmune diseases have several etiologies. acute chlamydia pneumoniae (c. pneumoniae) infection may be involved in the pathogenesis of several autoimmune diseases. in this study, 82 patients with several autoimmune diseases and 70 controls were enrolled, and acute c. pneumoniae infection has been evaluated by monitoring the levels of igm antibody. chlamydia pneumoniae igm positive results were observed in 29% (p < 0.05) of the patients with several autoimmune diseases and in 10% of the control ... | 2009 | 19151119 |
| a protein secreted by the respiratory pathogen chlamydia pneumoniae impairs il-17 signalling via interaction with human act1. | chlamydia pneumoniae is a common respiratory pathogen that has been associated with a variety of chronic diseases including asthma and atherosclerosis. chlamydiae are obligate intracellular parasites that primarily infect epithelial cells where they develop within a membrane-bound vacuole, termed an inclusion. interactions between the microorganism and eukaryotic cell can be mediated by chlamydial proteins inserted into the inclusion membrane. we describe here a novel c. pneumoniae-specific incl ... | 2009 | 19159390 |
| innate immunity and vaccines in chlamydial infection with special emphasis on chlamydia pneumoniae. | chlamydial infections are prevalent worldwide. immunological events related to both innate and adaptive immunity during chlamydial infection can aid in recovery from the disease, but they can also cause harmful effects (immunopathology). the host genetic factors (variation in innate immunity and adaptive response-related genes) can predispose individuals to infection and its sequelae as well as determine the effects of intervention. no effective vaccine is available for human use. modern technol ... | 2009 | 19159433 |
| conservation in the face of diversity: multistrain analysis of an intracellular bacterium. | with the recent completion of numerous sequenced bacterial genomes, notable advances have been made in understanding the level of conservation between various species. however, relatively little is known about the genomic diversity among strains. we determined the complete genome sequence of the florida strain of anaplasma marginale, and near complete (>96%) sequences for an additional three strains, for comparative analysis with the previously fully sequenced st. maries strain genome. | 2009 | 19134224 |
| anti-chlamydial antibiotic therapy for symptom improvement in peripheral artery disease: prospective evaluation of rifalazil effect on vascular symptoms of intermittent claudication and other endpoints in chlamydia pneumoniae seropositive patients (providence-1). | a potentially strong association exists between chlamydia pneumoniae and atherosclerosis, but the clinical benefits of antibiotic therapy have not been demonstrated. preliminary studies of antibiotic therapy in peripheral artery disease have shown a decreased need for revascularization and improved walking ability. the objective of this phase-iii trial was to assess the effect of a potent anti-chlamydial agent, rifalazil, on peak walking time in patients with symptomatic peripheral artery diseas ... | 2009 | 19139383 |
| chlamydia pneumoniae encodes a functional aromatic amino acid hydroxylase. | chlamydia pneumoniae is a community-acquired respiratory pathogen that has been associated with the development of atherosclerosis. analysis of the c. pneumoniae genome identified a gene (cpn1046) homologous to eukaryotic aromatic amino acid hydroxylases (aroaa-hs). aroaa-hs hydroxylate phenylalanine, tyrosine, and tryptophan into tyrosine, dihydroxyphenylalanine, and 5-hydroxytryptophan, respectively. sequence analysis of cpn1046 demonstrated that residues essential for aroaa-h enzymatic functi ... | 2009 | 19141112 |
| chlamydia pneumoniae induces macrophage-derived foam cell formation via ppar alpha and ppar gamma-dependent pathways. | in the presence of low density lipoprotein (ldl), chlamydia pneumoniae induces macrophage-derived foam cell formation, a typical pathological feature of early atherosclerosis. however, its mechanism has not been fully understood. peroxisome proliferator-activated receptors (ppars) are key regulators of macrophage lipid metabolism. this study therefore investigated the role that ppar alpha and ppar gamma may play a role in c. pneumoniae-induced foam cell formation. oil red o staining and lipid ma ... | 2009 | 19114110 |
| the transcript profile of persistent chlamydophila (chlamydia) pneumoniae in vitro depends on the means by which persistence is induced. | expression of specific bacterial genes is differentially regulated during persistent, vs. active, chlamydial infection. transcript patterns were examined using real-time reverse transcriptase-pcr in four in vitro models of persistence for chlamydia pneumoniae strain cwl 029, using hela cells and normal human monocytes as host. differential expression of genes encoding cell division proteins was variable when persistence was induced by interferon-gamma, penicillin g, or deferoxamine mesylate trea ... | 2009 | 19077059 |
| identification of viral and atypical bacterial pathogens in children hospitalized with acute respiratory infections in hong kong by multiplex pcr assays. | acute respiratory tract infection is a leading cause of hospital admission of children. this study used a broad capture, rapid and sensitive method (multiplex pcr assay) to detect 20 different respiratory pathogens including influenza a subtypes h1, h3, and h5; influenza b; parainfluenza types 1, 2, 3, and 4; respiratory syncytial virus (rsv) groups a and b; adenoviruses; human rhinoviruses; enteroviruses; human metapneumoviruses; human coronaviruses oc43, 229e, and sars-cov; chlamydophila pneum ... | 2009 | 19031443 |
| culture versus polymerase chain reaction for the etiologic diagnosis of community-acquired pneumonia in antibiotic-pretreated pediatric patients. | tracheal aspirates were collected from 176 hospitalized antibiotic-pretreated children with community-acquired pneumonia. haemophilus influenzae and streptococcus pneumoniae were detected by both culture and target-enriched multiplex (tem)-pcr whereas mycoplasma pneumoniae and chlamydia pneumoniae were detected by tem-pcr only. tem-pcr detected more s. pneumoniae (32 vs. 7) and h. influenzae (29 vs. 23) than did culture. tem-pcr detected an additional 26 m. pneumoniae and 1 c. pneumoniae. tem-pc ... | 2009 | 19034066 |
| chlamydia pneumoniae induces macrophage-derived foam cell formation by up-regulating acyl-coenzyme a: cholesterol acyltransferase 1. | in macrophages, the accumulation of cholesteryl esters synthesized by acyl-coenzyme a: cholesterol acyltransferase 1(acat1) plays a crucial role in foam cell formation, a hallmark of early atherosclerotic lesions. it is suggested that chlamydia pneumoniae (c. pneumoniae) induces foam cell formation. however, the mechanism of foam cell formation induced by c. pneumoniae has not been fully elucidated. in this study, we found that c. pneumoniae increased the expression of acyl-coenzyme a: cholester ... | 2009 | 19049899 |
| identification of high- and low-virulent strains of chlamydia pneumoniae by their characterization in a mouse pneumonia model. | contradicting reports exist about the pathogenicity of chlamydia pneumoniae and the severity of the respiratory disease they cause. this study aimed to clarify, in mice, our hypothesis that marked differences in virulence of well-defined c. pneumoniae strains might exist for lung infections. c57bl/6j mice were intranasally infected with equal amounts of five different, identically prepared laboratory strains of c. pneumoniae. based on the clinical score, weight, histopathological score, the gran ... | 2009 | 19076226 |
| chlamydophila pneumoniae diagnostics: importance of methodology in relation to timing of sampling. | the diagnostic impact of pcr-based detection was compared to single-serum igm antibody measurement and igg antibody seroconversion during an outbreak of chlamydophila pneumoniae in a military community. nasopharyngeal swabs for pcr-based detection, and serum, were obtained from 127 conscripts during the outbreak. serum, drawn many months before the outbreak, provided the baseline antibody status. c. pneumoniae igm and igg antibodies were assayed using microimmunofluorescence (mif), enzyme immuno ... | 2009 | 19046171 |
| host cell cytokines induced by chlamydia pneumoniae decrease the expression of interstitial collagens and fibronectin in fibroblasts. | chlamydia pneumoniae infection has been associated with chronic obstructive airway disease (copd), asthma, and atherosclerosis. inflammation and airway remodeling in asthma and copd result in subepithelial fibrosis that is characterized by the deposition of interstitial collagens and fibronectin. the progression of atherosclerosis is also accompanied by an increased production of interstitial collagens in the intima. as shown by reverse transcription-pcr and immunoblotting, infection of human fi ... | 2009 | 19047405 |
| in vitro characterisation of koala chlamydia pneumoniae: morphology, inclusion development and doubling time. | chlamydia pneumoniae is a common human and animal pathogen associated with upper and lower respiratory tract infections. of the animal c. pneumoniae isolates, the koala nasal isolate (lpcoln) is by far the best genetically characterised. this current study was designed to characterise the morphology and developmental events for the lpcoln isolate, and our results showed several striking in vitro growth differences when compared to the human isolate, ar39. the lpcoln inclusion size and morphology ... | 2009 | 19026498 |
| a real-time quantitative polymerase chain reaction assay for the detection of chlamydia in the mouse genital tract model. | chlamydia trachomatis is a human pathogen that infects genital tracts in women. disease control may be achieved through development of an efficacious vaccine. a mouse genital tract model serves as a tool for evaluation of vaccine candidates. currently, assessment of infection in mice is performed by enumeration of inclusion-forming units (ifus) through microscopic counting of fluorescently stained bacteria. we have developed a highly sensitive real-time quantitative polymerase chain reaction (rt ... | 2009 | 19026505 |
| chlamydia trachomatis polymorphic membrane protein d is an oligomeric autotransporter with a higher-order structure. | chlamydia trachomatis is a globally important obligate intracellular bacterial pathogen that is a leading cause of sexually transmitted disease and blinding trachoma. effective control of these diseases will likely require a preventative vaccine. c. trachomatis polymorphic membrane protein d (pmpd) is an attractive vaccine candidate as it is conserved among c. trachomatis strains and is a target of broadly cross-reactive neutralizing antibodies. we show here that immunoaffinity-purified native p ... | 2009 | 19001072 |
| occurrence of chlamydia trachomatis and chlamydia pneumoniae in paediatric respiratory infections. | an emerging body of evidence suggests that half of asthma in both children and adults is associated with chronic lung infection. the aim of the present study was to determine the frequency of viable chlamydia pneumoniae (cp) and c. trachomatis (ct) in the respiratory tracts of paediatric patients with chronic respiratory diseases. bronchoalveolar lavage fluid (balf) samples obtained from 182 children undergoing bronchoscopy for clinical reasons were assayed using pcr analysis, in vitro tissue cu ... | 2009 | 19010996 |
| chlamydophila pneumoniae myopericarditis in a child. | an 11-year-old boy with serologically confirmed chlamydophila pneumoniae infection presented with clinical, laboratory, and echocardiographic changes consistent with myopericarditis. no reports on c. pneumoniae myopericarditis in children are found in the medical literature. the boy, previously healthy, presented with fever, rash, constitutional symptoms, elevated acute phase reactants, elevated cardiac enzymes, and high brain natriuretic peptide levels. hemodynamic instabilities, including hypo ... | 2009 | 18953592 |
| azithromycin does not prevent six-month myointimal proliferation but attenuates the transient systemic inflammation occurring after coronary stenting. | stent implantation produces a systemic increase of inflammatory markers that correlates with chlamydophila pneumoniae infection in atherosclerotic plaque. we performed a clinical intervention study to investigate the effect of antibiotic treatment on 6-month follow-up angiographic minimal luminal diameter after stenting. | 2009 | 18853090 |
| initial characterization of chlamydophila (chlamydia) pneumoniae cultured from the late-onset alzheimer brain. | previous studies from this laboratory provided evidence that the intracellular bacterial pathogen chlamydophila (chlamydia) pneumoniae is present in the late-onset alzheimer's disease (ad) brain. here we report culture of the organism from two ad brain samples, each of which originated from a different geographic region of north america. culturable organisms were detectable after one and two passages in hep-2 cells for the two samples. both isolates, designated tor-1 and phi-1, were demonstrated ... | 2009 | 18829386 |
| chlamydia pneumoniae infection, complement factor h variants and age-related macular degeneration. | impaired inhibition of the alternative complement pathway by complement factor h (cfh) is linked to age-related macular degeneration (amd) based on the strong association between cfh variant and amd. chlamydia pneumoniae (c pneumoniae) infection can trigger the alternative pathway, but the evidence for an association between c pneumoniae and amd is contradictory. this study investigated whether c pneumoniae infection is associated with amd and whether the presence of c pneumonia modulates amd ri ... | 2009 | 18996904 |
| epidemiology of community-acquired pneumonia in older adults: a population-based study. | this study assessed incidence, aetiology, clinical outcomes and risk factors for community-acquired pneumonia (cap) in older adults. | 2009 | 18804355 |
| coronary artery disease patient's first degree relatives may be at higher risk for atherosclerosis. | our aim was to investigate the relationship between the serologic status concerning chlamydia pneumoniae (cp), helicobacter pylori (hp), cytomegalovirus (cmv) and high sensitive c-reactive protein (hscrp) in coronary artery disease (cad) patient's first degree relatives, which remain an unrevealed issue in literature. we studied 192 cad patients (pts), 140 cad-patient first degree relatives (cad-r) and 192 controls with no evidence of obstructive cad. seropositivity for cp igg (71 vs 50, p=0.090 ... | 2009 | 18572262 |
| chlamydia pneumoniae infection enhances microglial activation in atherosclerotic mice. | the presence of chlamydia pneumoniae in murine brain tissue was studied in atherosclerotic and non-atherosclerotic mice, after peritoneal injection. furthermore, we investigated whether increased permeability of the blood-brain barrier was implicated in cerebral c. pneumoniae infection and whether intra-cerebral c. pneumoniae infection leads to microglial activation. using a polymerase chain reaction, c. pneumoniae dna was found in the brain tissue of 33% of the mice, 3, 7 and 21 days after infe ... | 2010 | 19027992 |
| chlamydial lipopolysaccharide (clps) is present in atherosclerotic and aneurysmal arterial wall--clps levels depend on disease manifestation. | the role of chlamydia pneumoniae in peripheral atherosclerosis disease and abdominal aortic aneurysm (aaa) remains unclear. chlamydial lipopolysaccharide (clps) detection is a method used conventionally in routine chlamydial diagnosis of gynecological or ophthalmic samples. | 2010 | 19150246 |
| why first degree relatives of coronary artery disease patient's have chlamydia pneumoniae infection. | chlamydia pneumoniae (c. pneumoniae) infection in coronary artery disease (cad) is confirmed by many workers. however our knowledge on relationship between infection and atherosclerosis is still in infancy. in this report we discuss why should relatives of patients with cad have contracted c. pneumoniae infection? | 2010 | 19167109 |
| presence of chlamydophila pneumoniae dna but not mrna in stenotic aortic heart valves. | the pathogenesis of aortic valve stenosis may involve inflammation and we have previously demonstrated chlamydophila pneumoniae (c. pneumoniae) dna in stenotic aortic heart valves. dissemination of these bacteria is probably mediated by alveolar macrophages. bacterial dna alone does not indicate whether the bacteria are viable and replicating. this study aimed to investigate the presence of c. pneumoniae mrna, a marker of replicating bacteria, and c. pneumoniae dna in stenotic aortic valves and ... | 2010 | 19246110 |
| [mycoplasma pneumoniae and chlamydophila pneumoniae coinfection in severe pneumoniae among a hospitalized child with respiratory distress: what are the best diagnostic tools for an optimal care?]. | the role for mycoplasma pneumoniae and chlamydophila pneumoniae in lower and upper respiratory tract infections in childhood increased by use of specialised diagnostic techniques, more and more performant for the early diagnosis of these infections. however, the prevalence of m. pneumoniae and c. pneumoniae as a cause of severe pneumoniae among hospitalized children has been rarely described. we report a case of m. pneumoniae et c. pneumoniae coinfection in a 10-year-old child hospitalized with ... | 2010 | 19375247 |
| lack of chlamydophila pneumoniae and predominance of alloiococcus otitidis in middle ear fluids of children with otitis media with effusion. | to investigate the presence of chlamydophila pneumoniae and other bacterial pathogens in middle ear effusion samples obtained from children with otitis media with effusion (ome). | 2010 | 19879704 |
| infectious burden and risk of stroke: the northern manhattan study. | to determine the association between a composite measure of serological test results for common infections (chlamydia pneumoniae, helicobacter pylori, cytomegalovirus, and herpes simplex virus 1 and 2) and stroke risk in a prospective cohort study. | 2010 | 19901154 |
| plasmacytoid dendritic cells prevent cigarette smoke and chlamydophila pneumoniae-induced th2 inflammatory responses. | smoking promotes the development of allergic asthma and pneumonia. chlamydophila pneumoniae lung infection is associated with an increased risk for asthma, inducing an immune response regulated by dendritic cells (dcs). this study sought to determine whether exposure to cigarette smoke modulates the functional activity of cd11c-positive dcs in the lung, with and without concomitant c. pneumoniae infection. bone marrow-derived dcs (bmdcs) were exposed in vitro to cigarette smoke extract (cse) and ... | 2010 | 19901344 |
| a prospective study of multiple donor exposure blood recipients: surveillance value and limitations for hemovigilance. | there have been few recent systematic studies of blood recipients for direct evidence of blood safety, especially for emerging pathogens that may pose a threat to the blood supply. | 2010 | 19778336 |
| invariant nkt cells preferentially modulate the function of cd8 alpha+ dendritic cell subset in inducing type 1 immunity against infection. | although studies suggest that nkt cell (nkt) activation modulates the function of dendritic cells (dcs) in inducing t cell responses, it is unknown whether this modulating effect is biased to a dc subset. we previously reported that nkt activation could modulate dc function in inducing protective t cell immunity to chlamydia pneumoniae, an intracellular bacterial infection. in this study, we investigated the effect of nkt activation on dc subsets, using multiple approaches, including gene knocko ... | 2010 | 20089704 |
| interactions between flagellar and type iii secretion proteins in chlamydia pneumoniae. | flagellar secretion systems are utilized by a wide variety of bacteria to construct the flagellum, a conserved apparatus that allows for migration towards non-hostile, nutrient rich environments. chlamydia pneumoniae is an obligate, intracellular pathogen whose genome contains at least three orthologs of flagellar proteins, namely flii, flha and flif, but the role of these proteins remains unknown. | 2010 | 20096108 |
| in vitro antibacterial activity of phx-3 against helicobacter pylori. | phx-3, one of the phenoxazine derivatives, is reported to have inhibitory effect on mycobacterium species and chlamydia pneumoniae but not escherichia coli, salmonella typhimurium, pseudomonas aeruginosa, staphylococcus aureus, listeria monocytogenes. the bactericidal activities of phx-3 against helicobacter pylori strains have not been assessed. then, we measured minimum inhibitory concentration of phx-3 for helicobacter strains and assessed the morphological and biochemical effects of phx-3 on ... | 2010 | 20118538 |
| essential role of mitochondrial antiviral signaling, ifn regulatory factor (irf)3, and irf7 in chlamydophila pneumoniae-mediated ifn-beta response and control of bacterial replication in human endothelial cells. | chlamydophila pneumoniae infection of the vascular wall as well as activation of the transcription factor ifn regulatory factor (irf)3 have been linked to development of chronic vascular lesions and atherosclerosis. the innate immune system detects invading pathogens by use of pattern recognition receptors, some of which are able to stimulate irf3/7 activation and subsequent type i ifn production (e. g., ifn-beta). in this study, we show that infection of human endothelial cells with c. pneumoni ... | 2010 | 20154210 |
| combination antibiotics as a treatment for chronic chlamydia-induced reactive arthritis: a double-blind, placebo-controlled, prospective trial. | chlamydia trachomatis and chlamydophila (chlamydia) pneumoniae are known triggers of reactive arthritis (rea) and exist in a persistent metabolically active infection state in the synovium, suggesting that they may be susceptible to antimicrobial agents. the goal of this study was to investigate whether a 6-month course of combination antibiotics is an effective treatment for patients with chronic chlamydia-induced rea. | 2010 | 20155838 |
| is chlamydia pneumoniae the causative agent of microscopic polyangiitis? | 2010 | 20164047 | |
| immunological fingerprinting method for differentiation of serum samples in research-oriented biobanks. | an immunoenzymatic serum fingerprinting method was developed to establish a serum sample fingerprint based on igg titers obtained with three different antigens. three widely expressed antigens were selected for their capacity to induce long-lasting humoral immune responses. this fingerprinting method may be used to differentiate between two serum samples and to determine whether they come from the same primary blood specimen. the method showed a specificity of 99.5%. this method is suitable as a ... | 2010 | 20164255 |
| elevated serum immunoglobulin g titers against chlamydia pneumoniae in primary open-angle glaucoma patients without systemic disease. | to determine if chlamydia pneumoniae infection is associated with primary open-angle glaucoma (poag). | 2010 | 20164795 |
| macrolide antibiotics in the treatment of asthma. an update. | it seems clear that certain macrolide antibiotics exert anti-inflammatory and immune modulating effects beyond their purely antibacterial action, as has been demonstrated in a number of bronchial inflammatory disorders such as diffuse panbronchiolitis. randomised, controlled clinical trials involving larger patient samples are needed to confirm whether these actions are of clinical relevance in application to asthma. on the other hand, the macrolide antibiotics have a long half-life, with a prol ... | 2010 | 20171003 |
| chlamydophila pneumoniae. | chlamydophila pneumoniae is estimated to cause about 10% of community-acquired pneumonia (cap) cases and 5% of bronchitis cases, although most patients with c pneumoniae infection are asymptomatic, and the course of respiratory illness is relatively mild. the incubation period of c pneumoniae infection is around 21 days, and such symptoms as cough and malaise show a gradual onset, yet may persist for several weeks or months despite appropriate antibiotic therapy. diagnosis by nasopharyngeal spec ... | 2010 | 20171546 |
| the role of infection in carotid plaque pathogenesis and stability: the clinical evidence. | chlamydia pneumoniae was the first pathogen linked with carotid atherosclerotic changes and plaque rupture. currently, other common pathogens are also under investigation as potential contributors. | 2010 | 20180770 |
| chlamydophila pneumoniae infection and its role in neurological disorders. | chlamydophila pneumoniae is an intracellular pathogen responsible for a number of different acute and chronic infections. the recent deepening of knowledge on the biology and the use of increasingly more sensitive and specific molecular techniques has allowed demonstration of c. pneumoniae in a large number of persons suffering from different diseases including cardiovascular (atherosclerosis and stroke) and central nervous system (cns) disorders. despite this, many important issues remain unans ... | 2010 | 20182626 |
| chlamydia pneumoniae infection was associated with risk of mortality from coronary heart disease in japanese women but not men: the jacc study. | to investigate the association between chlamydia pneumoniae infection and mortality from coronary heart disease, a nested case-control study was conducted for 39,242 japanese who participated in the jacc study. | 2010 | 20215711 |
| chlamydia pneumoniae-induced memory cd4+ t-cell activation in human peripheral blood correlates with distinct antibody response patterns. | chlamydia pneumoniae is a frequent pathogen of the respiratory tract, and persistent infections with this obligate intracellular bacterium have been associated with different severe sequelae. although t-cell activation during acute c. pneumoniae infections has been described, little is known about the frequency or the role of the c. pneumoniae-specific memory t cells that reside in the human body after the resolution of the infection. in the present study, the c. pneumoniae-induced t-cell respon ... | 2010 | 20219874 |
| chlamydophila pneumoniae enhances secretion of vegf, tgf-beta and timp-1 from human bronchial epithelial cells under th2 dominant microenvironment. | chlamydophila pneumoniae infection in the airways is thought to be associated with the pathogenesis of asthma, especially in non-atopic severe asthma with irreversible airway obstruction that may be related to airway remodeling. here, we investigated whether c. pneumoniae infection enhances the secretion of critical chemical mediators for airway remodeling, such as vegf, tgf-beta, and timp-1, in human bronchial epithelial cells (becs) in a th2-dominant microenvironment. | 2010 | 20224677 |
| chlamydia pneumoniae igg and iga antibody titers and prognosis in patients with coronary heart disease: results from the claricor trial. | the association observed between coronary heart disease (chd) and chlamydia (chlamydophila) pneumoniae antibodies prompted, during the 1990s, several primary and secondary prevention trials with various antibiotics. in our claricor trial, a randomized placebo-controlled trial in 4372 patients with stable chd, a brief clarithromycin regimen was followed, unexpectedly, by increased long-term mortality. we now compare c. pneumoniae antibody levels at entry with population levels, with the patients' ... | 2010 | 20226329 |
| chlamydophila pneumoniae downregulates mhc-class ii expression by two cell type-specific mechanisms. | chlamydophila pneumoniae was shown to prevent ifn gamma-inducible upregulation of mhc-class ii molecules by secreting chlamydial protease-like activity factor (cpaf) into the cytosol of those host cells which support the complete bacterial replication cycle. cpaf acts by degrading upstream stimulatory factor 1 (usf-1). however, in cells like bone marrow-derived macrophages (bmm), which restrict chlamydial replication, we show that cpaf expression is barely detectable and the expression of usf-1 ... | 2010 | 20233301 |
| a systemic network for chlamydia pneumoniae entry into human cells. | bacterial entry is a multistep process triggering a complex network, yet the molecular complexity of this network remains largely unsolved. by employing a systems biology approach, we reveal a systemic bacterial-entry network initiated by chlamydia pneumoniae, a widespread opportunistic pathogen. the network consists of nine functional modules (i.e., groups of proteins) associated with various cellular functions, including receptor systems, cell adhesion, transcription, and endocytosis. the peak ... | 2010 | 20233927 |
| types of infectious outbreaks and their impact in elderly care facilities: a review of the literature. | infectious outbreaks in long-term care facilities (ltcfs) tend to have a significant impact on infection rates and mortality rates of the residents. | 2010 | 20332371 |
| evaluation of false-positive reaction with elisa for the detection of chlamydophila pneumoniae-specific igm antibody in adults. | 2010 | 20332585 |