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what can be learned from genotyping of fungi?multiple genotyping studies have been carried out in order to clarify the epidemiology of fungal infections, more specifically to determine the sources, transmission routes, and colonization patterns of fungal isolates. in this review, the results obtained in genotyping investigations of aspergillus isolates are summarized and discussed. furthermore, we examine the epidemiologic studies of candida albicans, exophiala dermatitidis and scedosporium apiospermum infections in patients with cystic fi ...201021067332
lack of standardization in the procedures for mycological examination of sputum samples from cf patients: a possible cause for variations in the prevalence of filamentous fungi.filamentous fungi and yeasts are increasingly isolated from respiratory secretions of patients with cystic fibrosis (cf), and persistent fungal colonization of the airways of such patients is thought to exacerbate lung damage. while many independent studies have identified aspergillus fumigatus complex as the principal colonizing fungus in cf, increased awareness of the role of fungi in cf pathology coupled with improved mycological culture and identification methods have resulted in a number of ...201021067335
n(α)-methyl coprogen b, a potential marker of the airway colonization by scedosporium apiospermum in patients with cystic fibrosis.scedosporium apiospermum is an emerging pathogen colonizing the airways of patients with cystic fibrosis (cf). while usually responsible for chronic colonization without clinical signs, this fungus may cause severe and often lethal infections in lung transplant recipients. early diagnosis of its airway colonization and appropriate treatment are required to eradicate the fungus when a lung transplantation is planned. here we propose an alternative to mycological examination of sputum samples base ...201021067336
successful treatment of scedosporium apiospermum soft tissue abscess with caspofungin and voriconazole in a severely immunocompromised patient with acute myeloid leukemia.we report the case of a 53-year-old female patient with refractory acute myeloid leukemia developing a necrotic, soft tissue abscess on the right forearm caused by scedosporium apiospermum during prolonged severe neutropenia (absolute white blood cell count <500/μl for 49 days). in the context of the severely immunocompromised state of the patient and her need for allogeneic hematopoietic stem cell transplantation (hsct), surgical treatment options were not favored. therefore, combined antifunga ...201020604906
diagnostic contribution of positron emission tomography with [18f]fluorodeoxyglucose for invasive fungal infections.optimal staging and evaluation of residual lesions of invasive fungal infections (ifis) are major challenges in the immunocompromised host. preliminary data have suggested that [¹⁸f]fluorodeoxyglucose ([¹⁸f]fdg) uptake may be observed in the course of active invasive fungal infections. the aim of this study was to assess the role of positron emission tomography with [¹⁸f]fdg ([¹⁸f]fdg-pet) in the diagnosis and staging of ifi. a prospective monocentric study evaluating [¹⁸f]fdg-pet in 30 consecut ...201120636432
effective prolonged therapy with voriconazole in a lung transplant recipient with spondylodiscitis induced by scedosporium apiospermum.scedosporium/pseudallescheria species are frequently seen in cystic fibrosis patients. however, disseminated forms after lung transplantation in these patients are rarely seen, but often with poor outcome. in this case report we describe a lung transplant recipient with cystic fibrosis who developed a spondylodiscitis that was caused by scedosporium apiospermum. the patient was treated with anti-fungal treatment by voriconazole for over three years with a clinical good response and without the n ...201122567471
scedosporium apiospermum catheter-related soft-tissue infection: a case report and review of the literature.we report a case of catheter-related scedosporium apiospermum soft-tissue infection. this ubiquitous filamentous fungus can cause human infection after traumatic subcutaneous implantation of its conidia or their inhalation in near-drowning cases. it has also been reported as an etiological agent in a growing number of hospital-acquired infections.201122142218
Scedosporium apiospermum atrial mycetomas after lung transplantation for cystic fibrosis.A 37-year-old patient with cystic fibrosis underwent double lung transplantation. She developed disseminated Scedosporium apiospermum infection 2 months after surgery. Along with multiple brain abscesses, lung infection, and chorioretinitis, a cardiac echo revealed 2 large intra-atrial mycetomas floating close to the right upper pulmonary vein orifice. The mycetomas were removed through a trans-atrial approach under cardiopulmonary by pass; histology and cultures confirmed the diagnosis. Despite ...201122093620
[mycetomas diagnosed in senegal from 2008 to 2010].mycetomas are inflammatory pseudotumours of subcutaneous and possibly osseous soft fabrics, generally polyfistulas with chronic mode of evolution.201124451559
metallopeptidase inhibitors arrest vital biological processes in the fungal pathogen scedosporium apiospermum.scedosporium apiospermum is an emerging agent of opportunistic mycoses in humans. previously, we showed that mycelia of s. apiospermum secreted metallopeptidases which were directly linked to the destruction of key host proteins. in this study, we analysed the effect of metallopeptidase inhibitors on s. apiospermum development. as germination of inhaled conidia is a crucial event in the infectious process of s. apiospermum, we studied the morphological transformation induced by the incubation of ...201119702620
cutaneous hyalohyphomycosis by scedosporium apiospermum in an immunocompromised patient.scedosporium apiospermum is a ubiquitous filamentous fungus that may infect immunocompetent patients after trauma and may cause severe and often fatal infections in immunocompromised hosts. here, we present the case of a 28-year-old female with s. apiospermum infection on the left forearm that had developed while she was on long-term immunosuppressant therapy. analysis of a skin biopsy specimen showed a mixed cell granuloma with hyaline septate hyphae. culture of the abscess revealed s. apiosper ...201119889175
infections caused by fungi of the scedosporium/pseudallescheria complex in veterinary species.fungi belonging to the scedosporium/pseudallescheria complex (spcf) have been known to cause human infections for nearly a century and are important human pathogens, with an increasing frequency of infection in patients with underlying conditions. there appears to be a lower incidence of infections with spcf in veterinary species, although this may be related to a lack of awareness of these diseases. important recent taxonomic changes in this group of fungi include the classification of pseudall ...201120580291
subconjunctival mycetoma caused by scedosporium apiospermum infection in a horse.an 11-year-old american saddlebred gelding was presented for evaluation of a nonpainful subconjunctival mass involving the lateral canthus of the left eye. other findings included a central corneal scar and a small central cataract of the lens in the left eye. fine-needle aspiration of the mass was performed and cytologic examination revealed marked pyogranulomatous inflammation with intralesional fungal hyphae, consistent with mycetoma. the fungal structures were elongated and characterized by ...201121291482
simultaneous detection and identification of aspergillus and mucorales species in tissues collected from patients with fungal rhinosinusitis.rapid detection and differentiation of aspergillus and mucorales species in fungal rhinosinusitis diagnosis are desirable, since the clinical management and prognosis associated with the two taxa are fundamentally different. we describe an assay based on a combination of broad-range pcr amplification and reverse line blot hybridization (pcr/rlb) to detect and differentiate the pathogens causing fungal rhinosinusitis, which include five aspergillus species (a. fumigatus, a. flavus, a. niger, a. t ...201121325541
development and validation of a multiplex pcr for detection of scedosporium spp. in respiratory tract specimens from patients with cystic fibrosis.the emergence of scedosporium infections in diverse groups of individuals, which are often treatment refractory, warrants timely and accurate laboratory diagnosis. species- or group-specific primers based on internal transcribed spacer (its) sequence polymorphisms were designed for scedosporium aurantiacum, scedosporium dehoogii, scedosporium prolificans, pseudallescheria boydii species complex (former clade 5)/pseudallescheria apiosperma (formerly classified as s. apiospermum sensu lato) and ps ...201121325557
fatal mycotic aneurysms due to scedosporium and pseudallescheria infection.angioinvasive complications of scedosporium infections are rare. we report two cases of mycotic aneurysm, following apparent localized infection, due to scedosporium apiospermum and pseudallescheria boydii. the thoracoabdominal aorta was affected in one patient, and cerebral vessels were affected in the other. despite voriconazole therapy and surgical resection, the patients died. previously reported cases are reviewed.201121430108
rhizomucor and scedosporium infection post hematopoietic stem-cell transplant.hematopoietic stem-cell transplant recipients are at increased risk of developing invasive fungal infections. this is a major cause of morbidity and mortality. we report a case of a 17-year-old male patient diagnosed with severe idiopathic acquired aplastic anemia who developed fungal pneumonitis due to rhizomucor sp. and rhinoencephalitis due to scedosporium apiospermum 6 and 8 months after undergoing allogeneic hematopoietic stem-cell transplant from an hla-matched unrelated donor. discussion ...201121547214
scedosporium infection in a patient with anti-tnfα therapy.patients on anti-tnfα therapy are at increased risk for rare opportunistic infections. here we are reporting a case of scedosporium apiospermum infection in a patient treated with anti-tnf for 5 years. patients on anti-tnfα need close follow-up and clinicians should be suspicious for atypical infections in these immunocompromised hosts.201121572800
clinical differences between invasive pulmonary infection by scedosporium apiospermum and invasive pulmonary aspergillosis.invasive pulmonary infection by scedosporium apiospermum (ipsa) and invasive pulmonary aspergillosis (ipa) are clinically similar. our objective was to identify clinical parameters that may differentiate ipsa from ipa. ours was a prospective cohort study that included patients with different degrees of immunosuppression and respiratory isolation of s. apiospermum (sca). episodes of invasive infection were classified according to the eortc and msg criteria. clinical variables corresponding to pa ...201121672039
deep skin infection of scedosporium apiospermum in a patient with refractory idiopathic thrombocytopenic purpura.infection of scedosporium apiospermum is very rare but is now emerging as an important cause of both localized and disseminated infections in immunocompromised patients. a 62-year-old woman, who had undergone steroid therapy for refractory idiopathic thrombocytopenic purpura and had a history of diffuse large b cell lymphoma, developed a deep skin ulcer complicated with lymphangitis. after culture study demonstrated the presence of s. apiospermum, voriconazole (vrcz) was administered and prompt ...201121673473
the importance of a proper aetiological diagnosis in the management of patients with invasive mycoses: a case report of a brain abscess by scedosporium apiospermum.scedosporium apiospermum is a saprobic fungus responsible for many different clinical manifestations. although it affects mostly immunocompromised patients, pulmonary and disseminated scedosporiosis have also been reported in immunocompetent subjects. it often causes subcutaneous mycetoma, despite its preferential tropism to cns. the authors describe a fatal case of a s. apiospermum brain abscess in a 58-year-old female. she was affected by chronic liver disease and idiopathic pulmonary fibrosis ...201121678124
management and outcome of microbial anterior scleritis.: to evaluate the prevalence, predisposing factors, and outcomes of bacterial and fungal scleritis.201121694595
[scedosporium apiospermum disseminated infection in a single lung transplant recipient.]background: scedosporium spp. are filamentous fungi, and the 2 most important species are scedosporium prolificans and scedosporium apiospermum. s. apiospermum accounts for approximately 25% of non-aspergi-llus filamentous fungi infections in organ transplant recipients. scedosporium can colonize the sinuses and airways of lung recipients with underlying pulmonary diseases, such as bronchiectasis or cystic fibrosis before transplant, and develop invasive disease after lung transplantation. in fa ...201121700235
[a case of lung scedosporiosis successfully treated with monitoring of plasma voriconazole concentration level].a 71-year-old man was referred because of fever and productive cough. his chest radiograph showed a large cavitary mass with an intracavitary mycetoma-like lesion in the left middle lung field. we undertook bronchoscopy and ct-guided biopsy, and both bronchial lavage fluid culture and ct-guided biopsy culture revealed scedosporium apiospermum. on a diagnosis of lung scedosporiosis, he was treated with 200 mg/day voriconazole for 2 months, but his symptoms did not improve. measurement of the plas ...201121688649
a case of cutaneous scedosporium infection in an immunocompromised patient.scedosporium apiospermum, the asexual stage of pseudoallescheria boydii, is a fungus ubiquitous in soil as well as organically polluted areas, where nitrogen-containing compounds are abundant. it is an emerging opportunistic pathogen that can range from cutaneous to disseminated infection and can be fatal within months of diagnosis. here we present a case of disseminated s. apiospermum infection with cutaneous manifestations in a 59-year-old woman with myelodysplastic syndrome, in remission from ...201122032175
Severe prosthetic joint infection in an immunocompetent male patient due to a therapy refractory Pseudallescheria apiosperma.Prosthetic joint infections (PJI) are rarely due to fungal agents and if so they are mainly caused by Candida strains. This case represents a PJI caused by a multi-drug resistant Pseudallescheria apiosperma, with poor in vivo response to itraconazole and voriconazole. This case differs also by the way of infection, since the joint infection did not follow a penetrating trauma. In the majority of cases, Scedosporium extremity infections remain local in immunocompetent individuals. We report a per ...201121995659
Dapsone hypersensitivity syndrome complicated by Scedosporium apiospermum pneumonia in an immunocompetent patient. 201122124953
Post-traumatic Pseudallescheria apiosperma osteomyelitis: positive outcome of a young immunocompetent male patient due to surgical intervention and voriconazole therapy. 201121995662
multiple scedosporium apiospermum abscesses in a woman survivor of a tsunami in northeastern japan: a case report.abstract:201122027347
reverse line blot hybridisation screening of pseudallescheria/scedosporium species in patients with cystic fibrosis.the pcr-rlb (reverse line blot hybridisation) was applied as a molecular technique for the detection of members of pseudallescheria and scedosporium from sputum of patients with cystic fibrosis (cf). fifty-nine sputum samples were collected from 52 cf patients, which were analysed by culture and pcr-rlb. conventional and semi-selective culture yielded five positive samples, but the pcr-rlb hybridisation assay permitted the detection of members of pseudallescheria/scedosporium in 32 out of 52 pat ...201121995657
phylogeny and immune evasion: a putative correlation for cerebral pseudallescheria/scedosporium infections.representatives of the genus pseudallescheria (anamorph: scedosporium) are saprobes and the aetiologic agent of invasive mycosis in humans. after dissemination, the central nervous system (cns) is one of the most affected organs. prerequisites for the survival of pseudallescheria/scedosporium in the host are the ability to acquire nutrients and to evade the immune attack. the cleavage of complement compounds via the secretion of fungal proteases might meet both challenges since proteolytic degra ...201121995663
scedosporium apiospermum skin infection mimicking tuberous xanthoma. 201121950379
evaluation of luminex xtag fungal analyte-specific reagents for rapid identification of clinically relevant fungi.invasive fungal infections (ifi) remain a serious threat to immunocompromised hosts. current diagnostic methods, including fungal culture and antigen detection, are slow and often lack specificity. rapid diagnostic tools with increased sensitivity and specificity could improve the care of patients with ifi. recently, luminex molecular diagnostics (toronto, canada) developed 23 analyte-specific reagents (asrs) for the detection of the most common clinically relevant fungi. this study's objective ...201121880976
Activities of E1210 and Comparator Agents Tested by CLSI and EUCAST Broth Microdilution Methods against Fusarium and Scedosporium Species Identified Using Molecular Methods.Fusarium (n = 67) and Scedosporium (n = 63) clinical isolates were tested by two reference broth microdilution (BMD) methods against a novel broad-spectrum (active against both yeasts and molds) antifungal, E1210, and comparator agents. E1210 inhibits the inositol acylation step in glycophosphatidylinositol (GPI) biosynthesis, resulting in defects in fungal cell wall biosynthesis. Five species complex organisms/species of Fusarium (4 isolates unspeciated) and 28 Scedosporium apiospermum, 7 Scedo ...201222083469
disseminated trichosporon mycotoxinivorans, aspergillus fumigatus, and scedosporium apiospermum coinfection after lung and liver transplantation in a cystic fibrosis patient.trichosporon mycotoxinivorans is a novel pathogen recently found in cystic fibrosis patients. we report the first case of a disseminated fatal infection with t. mycotoxinivorans associated with invasive aspergillus fumigatus and scedosporium apiospermum infection after lung and liver transplantation in a cystic fibrosis patient.201223035187
mri with magnetic resonance spectroscopy of multiple brain abscesses secondary to scedosporium apiospermum in two immunocompromised patients.scedosporium apiospermum is a deadly fungal infection that can infect the central nervous system, particularly in immunocompromised patients. we present two cases of scedosporium brain abscesses. the first case was fatal and relevant conventional mri and mr spectroscopy findings are discussed. to our knowledge, this is the first reported case of mr spectroscopy in scedosporium apiospermum abscesses. in the second case, the patient recovered and conventional mr findings are followed over several ...201223465993
evaluation of multiplexed pcr and liquid-phase array for identification of respiratory fungal pathogens.invasive fungal infections are the cause of serious morbidity and high mortality in immunocompromised patients. early laboratory diagnostic options remain limited; however, rapid detection and accurate identification may improve outcome. herein, multiplexed pcr followed by liquid-phase array was evaluated for detection and identification of common respiratory fungal pathogens, including aspergillus fumigatus, rhizopus microsporus, scedosporium apiospermum and fusarium solani. the limit of detect ...201222435876
intraventricular daptomycin and intravenous linezolid for the treatment of external ventricular-drain-associated ventriculitis due to vancomycin-resistant enterococcus faecium.to report the successful treatment of external ventricular-drain (evd)-associated infection due to vancomycin-resistant enterococcus faecium (vre) with intraventricular daptomycin and intravenous linezolid.201223232018
a rare presentation of concurrent scedosporium apiospermum and madurella grisea eumycetoma in an immunocompetent host.mycetoma is a disfiguring, chronic granulomatous infection which affects the skin and the underlying subcutaneous tissue. we present an atypical case of recurrent mycetoma without ulceration, in a 35-year-old immunocompetent male caused by scedosporium apiospermum sensu stricto and madurella grisea, occurring at two separate anatomical sites.201223133772
scedosporium apiospermum endophthalmitis: diffusion-weighted imaging in detecting subchoroidal abscess.to describe the imaging appearance of scedosporium apiospermum (s. apiosermum) endophthalmitis in an immunocompetent female who underwent high resolution magnetic resonance imaging (mri) of the orbits and showed subchoroidal abscess on diffusion-weighted imaging.201223204835
scedosporium apiospermum peritonitis in a patient undergoing peritoneal dialysis. 201222725716
persistent erythematous plaque after minor trauma in an immunocompromised woman.scedosporium apiospermum is a ubiquitous soil fungus with a worldwide distribution. it can cause a wide range of clinical disease, from cutaneous and subcutaneous infections, to pneumonia, brain abscess, and life threatening systemic illness. the diagnosis of cutaneous disease is with biopsy and culture. we discuss the case of an elderly immunocompromised woman who presented with a persistent erythematous plaque on the elbow after minor trauma. a biopsy revealed scedosporium apiospermum. treatme ...201222559017
scedosporium apiospermum keratomycosis in a dog.a 6-year-old male castrated norfolk terrier dog was examined following a 21-day history of an increasingly painful eye. examination revealed marked blepharospasm and purulent ocular discharge associated with an ulcerative keratitis. there was panstromal corneal opacity with raised gray to white lesions. corneal cytology demonstrated branching septate fungal hyphae identified by polymerase chain reaction as scedosporium apiospermum. treatment with topical 1% voriconazole solution was successful i ...201222432768
scedosporium apiospermum endopthalmitis treated early with intravitreous voriconazole results in recovery of vision.the purpose of this study is to report a case of endogenous endopthalmitis caused by scedosporium apiospermum with a favorable outcome and review previously reported cases, their treatment regimens and outcomes.201222370908
[slow onset septic arthritis by scedosporium apiospermum after periarticular infiltration].fungal arthritis is usually of haematogenous origin, and mainly affects patients with impaired cellular immunity or users of intravenous drugs. the infection in immunocompetent patients is generally caused by direct inoculation of the microorganism through an invasive device. the experience of azole therapy in these patients is limited.201222366127
unilateral cacosmia: a presentation of maxillary fungal infestation.we present a case of long-standing unilateral cacosmia in a healthy 67-year-old man due to maxillary fungal infestation. treatment with septoplasty had been attempted 10 years prior but no further investigation or management undertaken and symptoms continued. subsequent mri scan revealed significant opacification of the left maxillary sinus. this was readily amenable to treatment by balloon sinuplasty. this yielded viscous grey mucus which grew scedosporium apiospermum. the case highlights the n ...201323563684
post-tsunami primary scedosporium apiospermum osteomyelitis of the knee in an immunocompetent patient.scedosporium apiospermum is a filamentous fungus present in soil and polluted waters that may cause infection by direct inoculation. osteomyelitis represents a challenge both for diagnosis and treatment. we report a case of post-tsunami primary s. apiospermum osteomyelitis of the knee in an immunocompetent patient.201323523561
refractory scedosporium apiospermum keratitis successfully treated with combination of amphotericin b and voriconazole.aim. to report a case of refractory fungal keratitis caused by scedosporium apiospermum. methods. interventional case report. results. a 47-year-old malay housewife presented with left eye cornea ulcer as her first presentation of diabetes mellitus. there was no history of ocular trauma, contact lens used, or cornea foreign body. scedosporium apiospermum was isolated from the cornea scrapping. her cornea ulcer initially responded well to topical amphotericin b within 3 days but subsequently wors ...201323509650
dermatic scedosporium apiospermum infection after autologous bone marrow transplantation.infection with scedosporium apiospermum (s. apiospermum) is rare, although it is associated with a high fatality rate, especially in immunosuppressed patients. a 23-year-old man with acute myelogenous leukemia (aml) (m2) who was pretreated with chemotherapy for autologous bone marrow transplantation developed a skin ulcer on the left groin. after a culture study demonstrated the presence of s. apiospermum, voriconazole was administered and the lesion rapidly improved. since a diagnosis of s. api ...201323503412
distribution of the different species of the pseudallescheria boydii/scedosporium apiospermum complex in french patients with cystic fibrosis.as various new sibling species within the pseudallescheria boydii/scedosporium apiospermum complex have been described recently with differences in their susceptibility to antifungals, this study was conducted in order to determine their respective frequency in cystic fibrosis. results indicated that p. boydii largely predominated (62%), followed by s. apiospermum (24%), scedosporium aurantiacum (10%) and pseudallescheria minutispora (4%). scedosporium dehoogii was not recovered in this study. t ...201323461512
cerebral scedosporium apiospermum infection presenting with intestinal manifestations.we present a case of cerebral scedosporium apiospermum infection presenting with intestinal manifestations in a 64-year-old male patient on immunosuppression for orthotopic liver transplantation. at admission, the patient's chief complaint was chronic watery diarrhea and he was found to have colonic ulcers on endoscopy. his hospital course was complicated by a tonic-clonic seizure caused by a left frontal brain abscess, with the causative agent being identified by culture. he was treated with lo ...201323440749
experimental models of disseminated scedosporiosis with cerebral involvement.scedosporium apiospermum is a soil fungus which can cause severe and often fatal cerebral infections in both immunocompetent patients in the event of near drowning and immunosuppressed patients such as lung transplant recipients. because of the low susceptibility of this fungus to antifungal drugs, and the low permeability of the blood-brain barrier (bbb), therapeutic drug monitoring is necessary to reach an effective tissue concentration with limited side effects. indeed, diffusion of the drug ...201323426955
scedosporium apiospermum soft tissue infection as the initial presentation of acute myeloid leukemia: a case report. 201323319688
[fungal keratitis caused by scedosporium apiospermum: first report from turkey].fungal keratitis, an eye infection with poor prognosis, is difficult to treat and can lead to loss of vision. among filamentous fungi scedosporium spp. rarely lead to fungal keratitis. here we present a case of keratitis caused by scedosporium apiospermum. a 61-year-old female patient was admitted to our hospital with the complaints of right eye pain and decreased vision after a foreign body trauma to the right eye. the patient was diagnosed as keratitis by biomicroscopic examination. conjunctiv ...201324237443
skin infection caused by scedosporium apiospermum in immunocompromised patients. report of two cases.scedosporium apiospermum is a filamentous fungus that can cause cutaneous or extracutaneous disease. a large number of cases have been published over the last decades, mainly in patients immunocompromised as a result of their disease or treatment. these kinds of infections can progress rapidly and become disseminated, leading to very serious or even fatal complications. we report two new cases of skin infection by scedosporium apiospermum from our hospital.201324139365
treatment of a brain abscess caused by scedosporium apiospermum and phaeoacremonium parasiticum in a renal transplant recipient.cerebral mycosis is a significant cause of morbidity among immunocompromised populations. we present here a case of cerebral infection with scedosporium apiospermum and phaeoacremonium parasiticum in a 49-year-old renal transplant recipient. fourteen years after renal transplantation, the patient presented with invasive pulmonary aspergillosis treated with intravenous liposomal amphotericin b. the patient had clinical and radiographic improvement. however, 6 weeks later, the patient presented wi ...201324050081
an unusual cause of diarrhea in an immunocompromised patient. scedosporium apiospermum colitis and brain abscess. 201323896373
antifungal effects of palmitic acid salt and ultrapure soft water on scedosporium apiospermum.scedosporium apiospermum sometimes causes serious infectious diseases on the skin of immunodeficient subjects. antifungal effects of fatty acid salts in soap against s. apiospermum were investigated under different water conditions.201323826728
multilocus sequence typing of scedosporium apiospermum and pseudallescheria boydii isolates from cystic fibrosis patients.scedosporium and pseudallescheria species are the second most common lung-colonising fungi in cystic fibrosis (cf) patients. for epidemiological reasons it is important to trace sources of infection, routes of transmission and to determine whether these fungi are transient or permanent colonisers of the respiratory tract. molecular typing methods like multilocus sequence typing (mlst) help provide this data.201323764085
combination antifungal therapy in the treatment of scedosporium apiospermum central nervous system infections.treatment of scedosporium apiospermum central nervous system (cns) infection typically consists of an azole in combination with surgical debridement. this approach requires prolonged treatment and carries a high associated mortality. we present two cases of the successful treatment of s. apiospermum cns infections with the combination of voriconazole and terbinafine.201323738164
successful prevention of scedosporiosis after lung transplantation in a cystic fibrosis patient by combined local and systemic triazole therapy.a persistent colonization with scedosporium apiospermum (s. apiospermum) often results in disseminated infection with a high mortality rate in immunosuppressed patients. we present the first case of successful prevention of scedosporiosis in an adolescent female cystic fibrosis patient post double lung transplant, with a combination of local and systemic voriconazole therapy and surgical intervention.201324432232
scedosporium apiospermum brain abscesses in an immunocompetent man with silicosis.we report a case of scedosporium apiosporum brain abscesses in an immunocompetent 69-year-old man with a history of silicosis. delayed diagnosis and institution of antifungal therapy was associated with neurological impairment, with subsequent complications resulting in death, highlighting the need for early diagnostic aspiration of brain abscesses non-responsive to antibiotics. we propose that, in the absence of identifiable immunosuppression, silicosis may have been a contributing factor to th ...201324432222
management of scedosporium apiospermum in a pre- and post-lung transplant patient with cystic fibrosis.although the predominant type of infection seen in the cystic fibrosis lung remains bacterial, fungal organisms are being isolated more frequently and are associated with a high mortality rate in lung transplant recipients. we present a case of a patient with cf with sputum cultures positive for scedosporium apiospermum prior to a successful lung transplant. she remains without evidence of infection 18 months later following treatment with a combination of triazoles and terbinafine.201324432212
diabetic foot ulcer due to scedosporium apiospermum.we report a case of diabetic foot ulcer caused by scedosporium apiospermum in a seventy year old male patient with uncontrolled diabetes. scedosporium apiospermum, the asexual phase of pseudallescheria boydii a fungus isolated from a variety of natural substrates throughout the world including soil, polluted water, sewage and manure of poultry and cattle. p.boydii is now recognized as a medically important opportunistic fungus. this case has been reported for its rarity.201324392407
white grain mycetoma caused by scedosporium apiospermum in north india: a case report.mycetoma is chronic granulomatous infection of skin and subcutaneous tissue caused by both bacteria and fungi. we report a case of mycetoma caused by scedosporium apiospermum in the right foot of a 45-year-old farmer in north india. the patient had a history of trauma in the sole of the right foot followed by discharge of white granules along with proximal progression. scedosporium apiospermum was identified based on colony characteristics and microscopic features on slide culture. mycetoma is a ...201324356247
[isolation of scedosporium apiospermum (teleomorph: pseudallescheria apiosperma) from an acute myeloid leukemia patient].scedosporium apiospermum is an emerging opportunistic pathogen that may lead to life-threatening infections especially in immunosuppressive individuals. in this report, s.apiospermum infection in a 62 year old male patient with acute myeloid leukemia was presented. during remission-induction chemotherapy, piperacillin-tazobactam therapy was started for febrile neutropenia. since fever had continued, treatment was switched to imipenem and also amphotericin b deoxycholate was added to the treatmen ...201323621736
eumycetoma.eumycetoma is caused by different fungi. madurella mycetomatis, madurella grisae, and scedosporium apiospermum are the most common causative agents. this disease is more frequent on the lower extremities but can also be present in other areas. the diagnosis is made by direct microscopic examination and histologic study, which should show hyphae and vesicles characteristic of the fungi. etiologic identification of the species of the fungus is sometimes difficult by culture and biopsy specimen; in ...201322682186
isolation and molecular identification of keratinophilic fungi from public parks soil in shiraz, iran.keratinophilic fungi are an important group of fungi that live in soil. the aim of this study was to isolate and identify keratinophilic fungi from the soil of different parks in shiraz.201323956993
scedosporium aurantiacum brain abscess after near-drowning in a survivor of a tsunami in japan.many victims of the tsunami that occurred following the great east japan earthquake on march 11, 2011 developed systemic disorders owing to aspiration pneumonia. herein, we report a case of tsunami lung wherein scedosporium aurantiacum was detected in the respiratory tract. a magnetic resonance image of the patient's head confirmed multiple brain abscesses and lateral right ventricle enlargement. in this case report, we describe a potential refractory multidrug-resistant infection following a ts ...201324238227
erratum to "a rare presentation of concurrent scedosporium apiospermum and madurella grisea eumycetoma in an immunocompetent host". 201323533896
mycotic keratitis: epidemiology, diagnosis and management.mycotic keratitis (an infection of the cornea) is an important ocular infection, especially in young male outdoor workers. there are two frequent presentations: keratitis due to filamentous fungi (fusarium, aspergillus, phaeohyphomycetes and scedosporium apiospermum are frequent causes) and keratitis due to yeast-like fungi (candida albicans and other candida species). in the former, trauma is usually the sole predisposing factor, although previous use of corticosteroids and contact lens wear ar ...201323398543
clinical utility of a panfungal polymerase chain reaction assay for invasive fungal diseases in patients with haematologic disorders.invasive fungal diseases (ifds) are life-threatening events in patients with haematologic disorders, and the spectrum of the aetiological pathogens continues to expand. this study aimed to evaluate the clinical utility of a panfungal polymerase chain reaction (pcr) assay for the management of ifds in such patients.201323360173
critical tests for determination of microbiological quality and biological activity in commercial vermicompost samples of different origins.the aim of the present paper was to show that differences in biological activity among commercially produced vermicompost samples can be found by using a relatively simple test system consisting of microorganism tests on six microbiological media and soilless seedling growth tests with four vegetable crop species. significant differences in biological properties among analyzed samples were evident both at the level of microbial load as well as plant growth-affecting activity. these differences w ...201323504062
fungi in the cystic fibrosis lung: bystanders or pathogens?improvement to the life expectancy of people with cystic fibrosis (pwcf) brings about novel challenges including the need for evaluation of the role of fungi in the cystic fibrosis (cf) lung. to determine if such organisms represent bystanders or pathogens affecting clinical outcomes we review the existing knowledge from a clinical, biochemical, inflammatory and immunological perspective. the prevalence and importance of fungi in the cf airway has likely been underestimated with the most frequen ...201424625547
impact of scedosporium apiospermum complex seroprevalence in patients with cystic fibrosis.species of the scedosporium apiospermum complex (s. a complex) are emerging fungi responsible for chronic airway colonization in cystic fibrosis (cf) patients. recent studies performed on aspergillus fumigatus suggest that the colonization of the airways by filamentous fungi may contribute to the progressive deterioration of lung function.201424530191
different colonization patterns of aspergillus terreus in patients with cystic fibrosis.aspergillus terreus is a common soil saprophyte. after aspergillus fumigatus and scedosporium apiospermum it ranks third amongst the filamentous fungi colonizing the airways of patients with cystic fibrosis. in this context, the clinical presentation of a. terreus infection mainly corresponds to allergic broncho-pulmonary aspergillosis. in the work presented here, we studied colonization patterns of a. terreus in cf patients by genotyping using nine short tandem repeat markers. a total of 115 cl ...201423927682
modified culture method detects a high diversity of fungal species in cystic fibrosis patients.cystic fibrosis (cf) is one of the most common genetic lung diseases worldwide. the production of sticky viscous mucus leads to enhanced bacterial colonization and infection, but yeasts and filamentous fungi are also found abundantly in the mucus of patients suffering from cf. the role of fungi in the airways of cf patients is still not understood completely. furthermore, recent investigations have shown that the spectrum of fungi isolated from the airways of cf patients depends strongly on the ...201423651180
matrix-assisted laser desorption ionization-time of flight mass spectrometry for fast and accurate identification of pseudallescheria/scedosporium species.an increasing number of infections due to pseudallescheria/scedosporium species has been reported during the past decades, both in immunocompromised and immunocompetent patients. additionally, these fungi are now recognized worldwide as common agents of fungal colonization of the airways in cystic fibrosis patients, which represents a risk factor for disseminated infections after lung transplantation. currently six species are described within the pseudallescheria/scedosporium genus, including s ...201424476388
nebulized voriconazole in infections with scedosporium apiospermum--case report and review of the literature.scedosporium infections are rare complications in immunocompromised patients or patients with chronic pulmonary disease. while scedosporium prolificans is resistant to most antimycotics, scedosporium apiospermum is usually sensitive to voriconazole and posaconazole. pharmacokinetics and efficacy of nebulized voriconazole have been described in a murine model previously. we report for the first time the safe and effective use of nebulized voriconazole for the treatment of severe pulmonary infecti ...201424263169
epidemiology, clinical manifestations, and outcomes of scedosporium infections among solid organ transplant recipients.few studies of scedosporium infections following solid organ transplantation have been performed in the era of induction immunosuppression and widespread antifungal prophylaxis.201424962102
pseudallescheria endophthalmitis: four cases over 15 years in queensland, australia, and a review of the literature.to describe the clinical features and outcomes of patients with culture-proven pseudallescheria endophthalmitis in the context of previously published cases.201424695065
co-infection of scedosporium apiospermum and mycobacterium chelonae in an immunocompetent host.a 75-year-old man presented with multiple, scaly, erythematous, grouped papules, nodules and plaques with tenderness ranging from the right forearm to hand dorsum and the right lower leg for 2-3 months. five months prior to presentation, the patient had received an antibiotic skin test on his right forearm. lesions appeared approximately 2-3 months after the antibiotic skin test, slowly progressing without clinical improvement. culture for fungus on the right forearm revealed growth of scedospor ...201425228156
a rare case of cytomegalovirus, scedosporium apiospermum and mycobacterium tuberculosis in a renal transplant recipient.renal transplant recipients are at high risk of developing multiple infections, often concomitantly because of their immunocompromised status. post renal transplant infections are often elusive and require extensive evaluation for proper diagnosis and treatment. a high index of suspicion is required and an attempt should be made to confirm the microbiological diagnosis from each site involved to rule out multiple infections.201424885965
susceptibility and diversity in the therapy-refractory genus scedosporium.scedosporium species show decreased susceptibility to the majority of systemic antifungal drugs. acquired resistance is likely to disseminate differentially with the mode of exchange of genetic material between lineages. inter- and intraspecific diversities of scedosporium species were analyzed for three partitions (rdna internal transcribed spacer gene [its], partial β-tubulin gene, and amplified fragment length polymorphism profiles), with the aim to establish distribution of resistance betwee ...201425070092
fungal keratitis secondary to scedosporium apiospermum infection and successful treatment with surgical and medical intervention.to report a rare case of severe fungal keratitis caused by scedosporium apiospermum, which was treated with a penetrating tectonic keratoplasty and aggressive medical treatment. a 62-year-old woman with a history of soil contamination of the right eye while planting vegetables presented with a severe corneal abscess and ocular pain. the patient received medical treatment and underwent tectonic keratoplasty. both corneal scrapings and the corneal button were evaluated microscopically. the samples ...201423612853
scedosporium apiospermum eumycetoma successfully treated with oral voriconazole: report of a case and review of the brazilian reports on scedosporiosis.we describe a case of white-grain eumycetoma caused by scedosporium apiospermum in an immunocompetent host that was successfully treated with oral voriconazole, and we review the brazilian reports on scedosporiosis.201423563766
[battery of rockets "scedosporium apiospermum" in mycotic keratitis]. 201424576568
sporotrichoid eruption in a patient after lung transplantation. scedosporium apiospermum fungal thrombophlebitis and sporotrichoid nodules. 201424258488
mycotic keratitis due to scedosporium apiospermum in layer pullets.investigation of ocular disease in a flock of layer pullets identified corneal infection with scedosporium apiospermum, a fungus of emerging significance in medicine and veterinary medicine.201423710763
assessing micafungin/triazole combinations for the treatment of invasive scedosporiosis due to scedosporium apiospermum and scedosporium boydii.scedosporium infections are associated with high therapeutic failure rates. combination therapy may be an alternative approach to improve outcome. the in vitro and in vivo efficacy of micafungin plus posaconazole or plus voriconazole was investigated herein.201424986494
clinical and morphologic findings in disseminated scedosporium apiospermum infections in immunocompromised patients.scedosporium apiospermum is a ubiquitous, saprophytic, filamentous mold that may cause localized, subcutaneous infections in immunocompetent hosts, but disseminated infection in severely immunocompromised patients. this mold is often highly resistant to multiple commonly used antifungal drugs. even with treatment, there is a high mortality rate. we present two patients with fatal disseminated s. apiospermum infections after bone marrow and lung transplantation. this infection can be rapidly fata ...201424982580
polymicrobial sclerokeratitis caused by scedosporium apiospermum and aspergillus cibarius.the aim of this study was to report the first case of polymicrobial fungal sclerokeratitis caused by infection with both scedosporium apiospermum and aspergillus cibarius, and notify the medical community of the possibility of infection caused by a. cibarius in humans.201424937168
characterization of scedosporium apiospermum glucosylceramides and their involvement in fungal development and macrophage functions.scedosporium apiospermum is an emerging fungal pathogen that causes both localized and disseminated infections in immunocompromised patients. glucosylceramides (cmh, glccer) are the main neutral glycosphingolipids expressed in fungal cells. in this study, glucosylceramides (glccer) were extracted and purified in several chromatographic steps. using high-performance thin layer chromatography (hptlc) and electrospray ionization mass spectrometry (esi-ms), n-2'-hydroxyhexadecanoyl-1-β-d-glucopyrano ...201424878570
tumorlike cardiac fungal mycetoma caused by scedosporium apiospermum presenting as symptomatic ventricular tachycardia. 201424821829
[fungal keratitis caused by scedosporium apiospermum: first report from turkey-comment].scedosporium apiospermum is a saprophytic fungus which is isolated worldwide in soil, fertilizers, polluted water, rotten vegetables, and other natural environments. it is the cause of mycetoma, a subcutaneous infection, characterized by granule formation. it may also cause severe local or diffuse infections in immunosuppressive patients. s.apiospermum-induced arthritis, endocarditis, keratitis, scleritis, endophthalmitis, meningitis, osteomyelitis, otomycosis, onychomycosis, chronic prostatitis ...201424819276
draft genome sequence of the pathogenic fungus scedosporium apiospermum.the first genome of one species of the scedosporium apiospermum complex, responsible for localized to severe disseminated infections according to the immune status of the host, will contribute to a better understanding of the pathogenicity of these fungi and also to the discovery of the mechanisms underlying their low susceptibility to current antifungals.201425278533
atypical fungal vertebral osteomyelitis in a tsunami survivor of the great east japan earthquake.case report.201424718064
human-impacted areas of france are environmental reservoirs of the pseudallescheria boydii/scedosporium apiospermum species complex.species of the pseudallescheria boydii/scedosporium apiospermum complex (psc) are emerging fungal pathogens able to chronically colonize the airways of patients with cystic fibrosis (cf). as p. boydii was found more frequently colonizing the lungs of cf patients in france than in other european countries in a previous report, the present study was conducted in order to clarify distribution of psc species in france and to characterize their natural habitat. the highest densities of psc isolates w ...201524684308
[deep skin infection with scedosporium apiospermum-infection in a renal transplant patient].a 57-year-old immunosuppressed patient presented with multiple erythematous papules and pustules as well as isolated ulcerations on the right lower leg and subcutaneous nodules on the right thigh. the biopsy revealed granulomatous inflammation with numerous fungal hyphae, which were identified as scedosporium apiospermum by pcr. he was treated with voriconazole 2 × 200 mg daily as well assurgical debridement. scedosporium apiospermum is a rare pathogenic agent of deep mold fungus infections. ski ...201525260303
scedo-select iii: a new semi-selective culture medium for detection of the scedosporium apiospermum species complex.the scedosporium apiospermum complex is responsible for a large variety of infections in human. members of this complex have become emerging fungal pathogens with an increasing occurrence in patients with underlying conditions such as immunosuppression or cystic fibrosis. a better knowledge of these fungi and of the sources of contamination of the patients is required and more accurate detection methods from the environment are needed. in this context, a highly selective culture medium was devel ...201525841055
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