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spread and distribution of human t-cell leukaemia virus type i-reactive antibody among baboons and monkeys in the northern and eastern transvaal.antibodies which probably indicate infection with human t-cell leukaemia virus type i (htlv-i) were determined in three species of non-human primates from several localities. a significant prevalence among chacma baboons and vervet monkeys was confirmed. according to sero-epidemiological evidence that htlv-i infection is predominantly sexually transmitted between adult animals; comparison of prevalence rates between localities or species should therefore take sexual maturity into account. it app ...19852986298
psorergatic acariasis in vervet monkeys.7 cases of acariasis were discovered amongst a colony of vervet monkeys (cercopithecus pygerythrus). lesions were confined to palpebrae and periorbital areas. skin scrapings and biopsies were taken and the parasite was identified as psorergates cercopitheci. the skin biopsies showed that the parasite invaded the superficial epidermis only. skin scrapings taken from other parts of the infested animals' bodies were all negative for mites. several of the infested animals have had physical contact w ...19852411999
genital signalling and the coexistence of male vervet monkeys (cercopithecus aethiops pygerythrus).to ascertain the social significance of male genital colouration two troops of vervets, one free-ranging and one caged, were observed. it was found that genital signals were associated with intermale agonism. it is suggested that this communicatory system regulates the behaviour of competitors and may thereby have facilitated the evolution of a multimale social system.19853833622
isobutyl cyanoacrylate: a clinical and histologic comparison with sutures in closing mucosal incisions in monkeys.bilateral vertical incisions were made in the maxillary and mandibular labial mucosa of eight young green vervet monkeys. incisions were closed with either interrupted 4-0 black silk sutures or by the application of isobutyl cyanoacrylate. mucosal specimens containing the incisions were examined histologically and scored for degree of inflammation at 1, 3, 10, and 20 weeks. the results showed that cyanoacrylate and sutures did not produce similar inflammatory responses.19853856209
precipitated diazepam withdrawal elevates noradrenergic metabolism in primate brain.following treatment for seven days with diazepam (2.0 mg/kg i.m., b.i.d.), administration of the benzodiazepine receptor antagonist ro 15-1788 (5 mg/kg) induced a severe withdrawal syndrome in vervet monkeys which included tremors, vomiting, vocalizations, chewing, and piloerection. brain concentrations of the noradrenergic metabolite 3-methoxy-4-hydroxyphenylglycol (mhpg) were significantly higher in the precipitated withdrawal group than in the diazepam plus vehicle control group. administrati ...19853920054
the effect of apicoectomy before replantation on periodontal and pulpal healing in teeth in monkeys.the effect of resection of the apical part of the root before replantation upon periodontal and pulpal healing was studied in 7 green vervet monkeys (cercopithecus aethiops) using teeth with incomplete and complete root formation. maxillary central incisors, mandibular lateral incisors and first and second mandibular molars were used in this experiment. on one side, the tooth was extracted and replanted with an intact root while the contralateral tooth had 2 mm of the apex resected for the purpo ...19853920162
"intestinal spirochaetosis" of the vervet monkey.electron microscopy revealed that 80% of captured vervet monkeys, held in quarantine for experimental use, showed extensive proliferation of spiral-shaped bacteria on the mucosal epithelium of the large bowel. a consortium, consisting of a predominant spirillum together with a spirochaete, was usually seen as a lawn covering the colonic epithelium. sparsely populated areas showed preferential colonization of the tubular glands. pathological changes were minimal, being confined to the microvillus ...19853925404
cryopreservation before replantation of mature teeth in monkeys. (ii). effect of preincubation, different freezing and equilibration rates and endodontic treatment upon periodontal healing.the effect of cryopreservation in liquid nitrogen at -196 degrees c for 1 week was studied by histometric analysis of 60 mature teeth replanted in 10 green vervet monkeys. the effect of preincubation in enriched tissue culture medium was also investigated. 2 different freezing rates were compared, and the effect of stepwise equilibration of dmso was studied as well as the effect of root canal treatment. the histometric analysis carried out 8 weeks after replantation revealed that if the cryoprot ...19853928511
isoproterenol dose-outflow facility response relationships in the vervet monkey.total outflow facility was measured by two-level constant pressure anterior chamber perfusion in surgically untouched vervet monkeys receiving intracameral infusions of mock aqueous humor without or with isoproterenol. bolus dl-isoproterenol sulfate doses of 1 to 10 micrograms, corresponding respectively to initial intracameral base concentrations of 2 x 10(-5) m and 2 x 10(-4) m, increased facility 30-50%; higher and lower bolus doses were ineffective, as were 0.1 and 1 g doses of 1-isoproteren ...19853930146
circadian rhythm of hmg-coa reductase and insulin in african green monkeys.hmg-coa reductase in hepatic microsomes and serum insulin display circadian rhythm in two strains of cercopethicus aethiops. grivets develop higher levels of serum cholesterol than vervets fed cholesterol. males (n = 20/gp) were adapted to a light cycle (7:30 a.m.-8:30 p.m.) for 60 days and fed a non-cholesterol diet at 8:30 a.m. and 2:00 p.m. vervet acrophase, reductase activity was synchronized to serum insulin units with a specific activity of 1480 pmol/min/mg protein changing by 7.5-fold fro ...19853888223
the pulpal response to dilute citric acid smear removers.the aim of this study was to determine the pulpal response to three dilute citric acid smear removers. forty-eight vervet monkeys (cercopithecus aethiops pygerythrus), in three groups of sixteen animals provided 384 tooth specimens for the histological evaluation of the pulpal response at 3, 31, and 59 days post-operatively. labial class v cavities were prepared in the maxillary and mandibular incisor teeth. the pulpal responses elicited by 1% aqueous citric acid, 1% citric acid in 30% ethanol a ...19853891932
steroid hormone influences on the mating behavior of vervet monkeys (cercopithecus aethiops).eight ovariectomized female vervet monkeys (cercopithecus aethiops) were tested in heterosexual and isosexual pairs, under estradiol and testosterone treatments. pairs were tested under two different experimental situations in which the male was either restrained or left free. there were only small behavioral changes across the treatments, involving mainly male responses. erection time, frequency of intromission, ejaculation, and olfactory investigation increased during estradiol treatment where ...19853979968
effects of ketamine anaesthesia, stress and repeated bleeding on the haematology of vervet monkeys.haematology values are presented for the vervet monkey (cercopithecus aethiops), and the relative effects of high dose ketamine anaesthesia, stress of capture and repeated bleedings assessed. anaesthesia resulted in decreased wbc and rbc values, attributed to depression of cardiovascular function. these effects were the reverse of those of alarm and strenuous exercise (leukocytosis and polycythaemia) during capture. stress resulted in relatively high white and low red blood cell counts. opposing ...19853999687
trypanosomal cardiac valvulitis in vervet monkeys.quarantined vervet monkeys (cercopithecus aethiops) were infected with trypanosoma brucei (10(4) parasites/animal) in a tsetse free area. thirteen monkeys (11 infected with t.b. rhodesiense and 2 with t.b. brucei) were studied. animals became parasitaemic within one week after infection. the infection time lasted between 21 and 129 days; in 8 monkeys it was between 50 and 70 days. macroscopically massive pericarditis was observed in one, pericardial effusion in one, small apical aneurysms in thr ...19854023556
serotonin-behavior interactions in vervet monkeys. 19854034859
serum testosterone, male dominance, and aggression in captive groups of vervet monkeys (cercopithecus aethiops sabaeus).the relationship of serum testosterone concentration to male dominance rank and frequency of aggression was investigated in stable vervet monkey social groups, each containing two or three adult males, several adult females, and their offspring. dominance relationships were determined by noting an animal's success in intermale aggressive encounters. a striking finding was the marked within-subject variation in testosterone concentration: 5- to 10-fold fluctuations were often observed on successi ...19854040114
estrogen and progesterone receptors in the uterus of the vervet monkey.experimental conditions for the optimal measurement of estrogen (er) and progesterone (pr) receptors in normal vervet monkey (cercopithecus aethiops pygerythrus) uteri are described. the uteri of this primate were found to contain relatively high concentrations of both er and pr. levels of er ranged from 151 to 822 femtomoles per mg protein (mean for group assayed is 327 +/- 165 femtomoles per mg protein). pr assays were performed on the same cytosols and the levels ranged from 444 to 2267 femto ...19854040971
captive propagation of vervet monkeys (cercopithecus aethiops) in harems.a small breeding colony of captive vervet monkeys (cercopithecus aethiops), consisting of ten single male harem groups, was established in kenya. vervets were extremely prone to stress after capture and manipulative procedures led to high mortalities. six weeks were required for partial habituation, after which routine handling was not too problematic. however, complete adjustment to captivity took a minimum of one year. establishment of stable breeding groups from adult animals initially proved ...19854046547
reversibility of the stabilization effect of sodium molybdate on uterine estrogen and progesterone receptors of the vervet monkey.sodium molybdate affected the stability of vervet monkey (cercopithecus aethiops pygerythrus) uterine estrogen (er) and progesterone (pr) receptors. yields of receptors were invariably higher (20-40%) when cytosols were prepared in the presence of 10mm sodium molybdate. no changes were observed in the binding affinities for the natural ligands as reflected in dissociation constants. receptor-ligand association at 0 degrees c and 20 degrees c was not affected in the presence or absence of molybda ...19854057178
phenylacetic acid production in dominant and non-dominant vervet monkeys.free and conjugated plasma phenylacetic acid concentrations were significantly higher in dominant male vervet monkeys than in non-dominant males living in stable social groups. these findings may be connected with an earlier observation that plasma from aggressive human psychopaths contains higher concentrations of phenylacetic acid than non-aggressive controls; whether they reflect an increased production of phenylethylamine is still unknown.19854058249
immunopathological aspects of trypanosomal meningoencephalitis in vervet monkeys after relapse following berenil treatment.four quarantined vervet monkeys were treated with intramuscular berenil in patent cns infection after experimental trypanosome inoculation with trypanosoma brucei rhodesiense or t. brucei brucei. all four animals relapsed in the post-therapeutic survival time of 37 to 209 days when they had fully developed meningoencephalitis in histological sections with the presence of interstitial intracerebral trypanosomes, which were confirmed in two monkeys by electron microscopy. in both, sequential sampl ...19854082265
dominant social status facilitates the behavioral effects of serotonergic agonists.the effects of dominance rank on the behavioral responses to drugs that enhance central serotonergic function were examined in 45 adult male vervet monkeys living in 15 stable social groups. each group contained 3 adult males, 3 adult females, and their immature offspring. dominance rank was assessed by measuring success in intermale agonistic encounters. in every group one male was clearly the dominant, or alpha male, and the other two males were subordinate. males from 5 groups received 3 dose ...19853878181
serum antibodies to human t-cell leukaemia virus type i in different ethnic groups and in non-human primates in south africa.the prevalence of humoral antibodies to human t-cell leukaemia virus type i (htlv-i) was investigated in different ethnic groups and in non-human primates in south africa. serum antibody levels were determined by enzyme-linked immunosorbent assay (elisa) using either disrupted whole htlv-i or purified p24 core protein (p24 htlv-i) as antigens. elisa was complemented by direct radio-immunoprecipitation assays using either purified iodinated p24 htlv-i or radiolabelled lysates of an htlv-producing ...19852984793
alteration of high density lipoprotein subfraction distribution with induction of serum amyloid a protein (saa) in the nonhuman primate.overnight chair restraint results in a dramatic increase in serum amyloid a protein (aposaa) of nonhuman primate high density lipoprotein (hdl). to determine whether aposaa induction resulted in a displacement of indigenous hdl protein or a change in the subfraction distribution of hdl, we analyzed the characteristics of hdl subfractions in eight vervet monkeys before and 24 hr after aposaa induction. blood was taken from each animal before and after chair restraint to induce aposaa. hdl was iso ...19853919135
absence of antibodies reactive with simian aids virus surface antigens in sera of vervet monkeys and baboons. 19853992388
noninvasive measurement of blood pressure in african green monkeys (cercopithecus aethiops).indirect measurements of arterial blood pressure were made in african green monkeys (cercopithecus aethiops) employing a doppler ultrasound stethoscope and standard cuff and an infrasonde automatic blood pressure recorder. measurements were obtained from anesthetized (10 mg/kg ketamine (hci) and unanesthetized (1.5 mg/kg ketamine hci) animals. ketamine had no significant effect on blood pressure. indirect measurements from the brachial artery were compared with direct femoral artery measurements ...198531979507
female mate choice in vervet monkeys (cercopithecus aethiops sabaeus).female mate choice was examined in a captive group of vervet monkeys (cercopithecus aethiops sabaeus). male-female interactions were examined under both dyadic and group conditions to determine whether females mate with different males under the two conditions. results showed that all females preferred to mate with the alpha male under both dyadic and group conditions. alpha females, however, were more successful than subordinate females in rejecting the sexual solicitations of subordinate males ...198631979492
reproduction in the vervet monkey (cercopithecus aethiops): i. testicular volume, testosterone, and seasonality.to test whether the male could contribute to the birth peak seen in both wild and captive vervets, testicular volume and peripheral testosterone concentration were measured monthly in nine adults throughout a 14-month period. volume was an average of 15% greater during the months of june to september, the period of natural breeding activity in the wild, than at other times of the year. testosterone concentration rose throughout the time period but did not correlate with testicular volume. quarte ...198631979482
group extinction and fusion in free-ranging vervet monkeys.three cases of group fusion were observed among vervet monkeys in amboseli national park, kenya, during the 1984 drought. in all cases, group fusion involved the migration of at least two females into a small neighboring group. following migration, the females' natal groups ceased to exist. although migrants initially assumed low ranks, none received high rates of aggression, and two rose in rank 6 months after their arrival. migrant females appeared to employ a number of "strategies," including ...198631979470
reproduction in the vervet monkey (cercopithecus aethiops): ii. annual menstrual patterns and seasonality.menstrual patterns and progesterone levels were monitored for 5 years from a cohort of 28 female vervet monkeys that were individually caged indoors. three distinct cycle types (short, normal, and prolonged) were defined according to cycle length. mean length of the normal cycle (32.5 days) and menses duration (4.8 days) are in agreement with previous reports. prolonged cycles (> 50 days) contributed 20% of the total, with a decreased incidence during the natural peak breeding period. weekly pro ...198631979437
resting cortisol levels and the emergence of dominant status among male vervet monkeys.resting serum cortisol was measured in adult male vervet monkeys (cercopithicus aethiops sabaeus) in four different conditions: (1) among groups with unaltered group membership and established dominance hierarchies; (2) among groups from which the original dominant male had been removed and in which the remaining males competed for dominant status; (3) among newly formed groups of three unfamiliar males each of which had been the dominant male in his previous group; and (4) among groups from whi ...19863957256
the histology and carbohydrate histochemistry of the lingual glands in vervet monkeys.the lingual salivary glands of the vervet monkey were examined for the first time to establish their histological appearance and mucosubstance histochemistry. sero-mucous and mucous glands are present. the mucin content of the serous glands is a neutral mucin, that of the mucus glands a carboxylated or sulphated sialomucin. the reason for the variation between cells was not established. anterior lingual glands were not detected in any of the tongues examined.19863468111
the influence of diet and dimethylhydrazine on the small and large intestine of vervet monkeys.the morphological features of the intestine in monkeys on various diets with and without carcinogen were studied. seventy adult female vervet monkeys were divided into seven treatment groups. four groups received a western high-fat low fibre diet (wd); two a prudent low-fat higher fibre diet (pd) and one a control low-fat high fibre diet (cd). three groups (2 wd, i pd) received dimethylhydrazine 10 mg/kg intramuscularly at 14 days intervals. after 18 months, monkeys of two groups on the wd were ...19862872910
transmitter-replacement therapy in alzheimer's disease using intracerebroventricular infusions of receptor agonists.neurotransmitter replacement therapy in alzheimer's disease is currently being attempted using bethanechol chloride (urecholine) infused intracerebroventricularly with an infusaid continuous infusion pump. the rationale of this therapy is based on the severe cortical pre-synaptic cholinergic deficit in the presence of relatively normal post-synaptic muscarinic receptor density. patients are selected on the basis of strict clinical criteria at a functional stage 4 or 5 of reisberg. a cortical bio ...19862878712
breeding vervet monkeys in a closed environment.a breeding group of vervet monkeys produced 95 offspring over five years. fetal wastage for 114 pregnancies was 16.7%. uterine sizes were recorded for 103 pregnancies in various stages of gestation. this enabled diagnosis of pregnancy, estimation of stage of gestation, and prediction of parturition to within two weeks. detailed observations were made on dental eruption, pelage development, and growth of 57 infants.19863806652
the suitability of east african primates as animal models of visceral leishmaniasis.the susceptibility of four east african primate species to experimental infection with leishmania donovani was investigated. vervet monkeys (cercopithecus aethiops), sykes monkeys (c. mitis) and baboons (papio cynocephalus) all supported low grade infections for periods ranging between four and eight months and subsequently showed evidence of self-cure. greater bushbabies (galago crassicaudatus) remained completely refractory throughout the course of the experiment. the significance of hepatic h ...19863810791
reproduction in the vervet monkey (cercopithecus aethiops): endometrial oestrogen and progestin receptor dynamics during normal and prolonged menstrual cycles.sixteen individually caged adult female vervet monkeys (cercopithecus aethiops), whose reproductive parameters had been studied for 5 years, were hysterectomized/ovariectomized during three reproductive states; i.e. the late follicular (15.4 +/- 4.7 (s.d.) days) and luteal (27.8 +/- 4.7 days) phases of the normal cycle (20-50 days), and during prolonged intermenstrual intervals (pii; 99.0 +/- 2.5 days since the previous menses). these latter animals showed characteristics of both follicular and ...19863760741
molybdate and the molecular properties of the vervet monkey estrogen receptor.the vervet monkey (cercopithecus aethiops pygerythrus) uterine estrogen receptor was partially characterised. the effect of the molybdate oxyanion on various molecular properties of the receptor was investigated. molybdate appeared to affect the subunit structure and apparent heterogeneity of the receptor. anion exchange chromatography of uterine cytosols yielded two ligand binding subunits in a 1:1 ratio in the absence of sodium molybdate, while only a single labelled complex could be demonstra ...19863795954
preferential vulnerability of a8 dopamine neurons in the primate to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.immunohistochemical examination of the midbrain of vervet monkeys treated with mptp revealed a marked loss of dopaminergic neurons in the lateral, but not medial, region of the a8 dopamine (da) cell group. in the same animals, the number of da neurons in the substantia nigra was only slightly decreased. biochemical assessment revealed a marked (greater than 85%) depletion of da in the striatum. however, in the da cell body regions significant decreases in da and homovanillic acid were observed o ...19863487756
natural infections of vervet monkeys (cercopithecus aethiops) and african red monkeys (erythrocebus patas) in sudan with taeniid cysticerci. 19863503150
evidence of blood cerebrospinal fluid barrier permeability impairment in chronic trypanosoma rhodesiense infection in a vervet monkey. 19863603626
effects of chronic fenfluramine on blood serotonin, cerebrospinal fluid metabolites, and behavior in monkeys.the effects of long term (70 days) fenfluramine treatment on selected physiological and behavioral measures were examined in four adult male vervet monkeys (cercopithecus aethiops sabaeus). relative to pretreatment baseline values, whole blood serotonin (wbs) and cerebrospinal fluid 5-hydroxyindole acetic acid (5-hiaa) were reduced, cerebrospinal fluid homovanillic acid (hva) was unaltered, and aggressive and locomotor behavior were increased. both physiological and behavioral effects were rever ...19862433707
influence of dietary fiber on lipids and aortic composition of vervet monkeys.a semipurified, cholesterol-free diet containing 40% carbohydrate can produce aortic sudanophilia or aortic atherosclerosis in vervet monkeys (cercopithecus aethiops pygerethrus) depending on the particular carbohydrate fed. four groups of vervet monkeys (three males and three females per group) were fed semipurified diets containing lactose. two of the groups were also fed 15% cellulose (c) or 15% cellulose plus 0.1% cholesterol (cc); the two other groups were fed 15% pectin (p) or 15% pectin p ...19863014255
stlv-i antibodies in feral populations of east african vervet monkeys (cercopithecus aethiops).serum samples from feral populations of african green monkeys (cercopithecus aethiops) were screened for antibodies to the simian t-lymphotropic virus, type i (stlv-i). blood samples had been collected from 336 monkeys in 4 regions of central and southern kenya in 1978 and 1979, from 114 monkeys in central ethiopia in 1973, and from 85 monkeys from the kampala region of uganda in 1966. a total of 178/535 monkeys (33%) were seropositive (stlv-i+). only 4/114 monkeys (4%) from ethiopia were seropo ...19863019900
use of procyclic trypanosomes for detection of antibodies in sera from vervet monkeys infected with trypanosoma rhodesiense: an immunodiagnostic test for african sleeping sickness.uncoated procyclic culture forms of african trypanosomes were used in immunofluorescence and simple agglutination assays to detect antibodies in the sera of vervet monkeys infected with t. b. rhodesiense. antibodies to procyclic surface antigens were found in sera from animals with active, untreated infections or sera taken soon after treatment with trypanocidal drugs. the antibodies were detectable within 7 days of infection. no specific antibodies were detected in sera prior to infection or lo ...19862882666
ethanol drinking by vervet monkeys (cercopithecus pygerethrus): individual responses of juvenile and adult males.unrestricted access of vervet monkeys to a palatable solution of ethanol resulted in chronic intake or abstinence. self-selected dose averaged 4.42 g/kg body mass/day. growth of juveniles was not grossly affected. in plasma, chronic ethanol intake was associated with lower average k and cl values, increased gamma glutamyl transpeptidase in some adults, and higher average total cholesterol. neither hepatic histology nor haematology were affected by chronic ethanol intake.19862874229
hepatitis in vervet monkeys caused by fusarium moniliforme.the fungus fusarium moniliforme sheldon is a common contaminant of maize (zea mays l.) intended for human and animal consumption throughout the world. culture material of f. moniliforme mrc 826, isolated from home-grown maize in an area in transkei, southern africa, with a high rate of human oesophageal cancer, was highly toxic to vervet monkeys (cercopithecus pygerythrus). ten monkeys were fed a standard primate diet which contained various amounts of culture material for 180 days. two control ...19872886517
intestinal structural changes in african green monkeys after long term psyllium or cellulose feeding.intestinal structure of male adult african green monkeys (cercopithecus aethiops ssp vervets) was studied after 3 1/2 yr of consuming diets containing 10% psyllium husk or cellulose. scanning electron microscopy (sem) identified mild damage (cellular swelling and disarray, and microvillar denudation and disarray) at villous tips throughout the small intestine in the psyllium-fed monkeys. the cellulose group had similar duodenal damage. differences were not found in colons by sem. by light micros ...19873031252
infection of vervet monkey bone marrow stromal cells with simian cytomegalovirus. 19873040871
the species-specific nature of the ototoxicity of dihydrostreptomycin in the patas monkey.the remarkable susceptibility of the inner ear of the patas monkey (erythrocebus patas) to the ototoxic action of dihydrostreptomycin (dhsm) (and streptomycin (sm)) is well established in this paper and affords a rare example of a species-specific reaction to a restricted class of compounds within the aminoglycoside group of antibiotics. in a series of experiments, behavioral and morphological observations together provided the following profile of dhsm ototoxicity in the patas monkey: sudden on ...19872436117
experimental extra-follicular histogenesis of follicular cysts.an animal model has been developed in which implantation cysts have been produced very close to developing teeth within the jaws of vervet monkeys. various deciduous teeth were extracted from both the maxilla and the mandible of 6 young vervet monkeys. after 4 weeks, full thickness mucoperiosteal flaps were raised in these areas, up to 6 recipient sites were prepared in each monkey by drilling holes in the alveolar bone and small pieces of autogenous palatal mucosa were placed in these graft rec ...19872441018
the genetic consequences of primate social organization: a review of macaques, baboons and vervet monkeys.primates, as long-lived, iteroparous, socially complex mammals, offer the opportunity to assess the effects of behavior and demography on genetic structure. because it is difficult to obtain tissue samples from wild primate populations, research in this area has largely been confined to terrestrial and semi-terrestrial old world monkeys (e.g., rhesus and japanese macaques, vervets and several subspecies of baboons). however, these species display a multi-male, multi-female social structure commo ...19873505885
proliferative activity of vervet monkey bone marrow-derived adherent cells.vervet monkey bone marrow-derived adherent cell population cultured in fischer's medium supplemented with 12.5% fetal calf serum and 12.5% horse serum consists of two cell shapes: fusiform (type i) and polygonal (type ii). limiting-dilution cloning of the cells suggested that the two morphologically distinct cell types belong to the same cellular system even though they differ in their proliferative capabilities. the labeling index of type ii cells, as measured by autoradiography, was found to b ...19873666073
a comparison of the effects of soya-bean protein and casein on bile composition, cholelithiasis and serum lipoprotein lipids in the vervet monkey (cercopithecus aethiops).1. two groups of vervet monkeys (cercopithecus aethiops) were fed on high-cholesterol diets which differed only with respect to the protein source. in one group casein was the only protein source, while the other group received only soya-bean protein. 2. samples of blood, bile and liver biopsy material were collected at the commencement of the study and at 3-monthly intervals until termination 12 months later. 3. at the end of the experimental period all the animals (n 19) had high plasma choles ...19873676246
leishmania major: the suitability of east african nonhuman primates as animal models for cutaneous leishmaniasis.the susceptibility of four species of east african nonhuman primates to experimental infection with leishmania major was investigated. four syke's monkeys (cercopithecus mitis), two vervet monkeys (cercopithecus aethiops), two baboons (papio cynocephalus), and two brown bushbabies (galago garnettii) were each inoculated intradermally on the left eyelid, left ear, and nose with 0.1 ml of medium containing 1 x 10(7) promastigotes of a characterized l. major strain. all the nonhuman primates except ...19873678449
segmental variations in the elastic fiber content of the lateral costotransverse ligaments in the vervet monkey (cercopithecus pygerythrus aethiops).the segmental and zonal variations in the quantitative relationships between elastic and collagen fibers within the lateral costotransverse ligaments have been investigated in the vervet monkey. the lateral costotransverse ligaments of the caudal segments have a largely elastic structure in contrast to those of the cranial segments, which are characteristically collagenous. in the transitional zone extending from the 4th through to the 6th costotransverse joints, the lateral costotransverse liga ...19873688468
seasonal variation of serum lipids in the vervet monkey.seasonal variation of serum lipids has been observed in man, primates and other species. we are presenting data on serum lipid variation in vervet monkeys (cercopithecus aethiops). the monkeys (54 males, 33 females) were fed control diets (commercial pellets, fruit, vegetables) and data were pooled and grouped by season. data having been obtained in south africa, the seasons were: summer (december, january, february); fall (march, april, may); winter (june, july, august); and spring (september, ...19873689478
vervet monkey (cercopithecus aethiops sabaeus) whole blood serotonin level is determined by platelet uptake sites.whole blood serotonin levels in adult male vervet monkeys living in social groups are sensitive to the animals' social environment. the mechanisms that translate different behavioral and environmental cues into altered whole blood serotonin levels are unknown. in this study, we have measured platelet number, size, serotonin content, and serotonin uptake, as well as the serum concentrations of tryptophan, mg+2 and ca+2. results showed that whole blood serotonin levels, platelet serotonin content, ...19873626771
leptospires in vervet monkeys (cercopithecus aethiops sabaeus) on barbados.agglutinins to leptospira were found at titers of greater than or equal to 1:100 in 150 of 501 (29.9%) vervet monkeys (cercopithecus aethiops sabaeus) bled within 1 mo of capture in barbados. including a further 34 of 145 bled within 1 yr of capture, the seropositivity prevalence was 28.5%. a further 35 monkeys (5.4%) had traces of agglutinins or gave titers of 1:50. the proportion of seropositive adults (41.5%) was more than twice that of seropositive immature monkeys (17.6%). among adults, 49. ...19873820429
homovanillic acid concentrations in brain, csf and plasma as indicators of central dopamine function in primates.in a large number (91) of vervet monkeys, correlation coefficients were determined between homovanillic acid (hva) concentrations in four brain areas. significant correlations existed between dorsal frontal cortex and orbital frontal cortex and between putamen and caudate nucleus. however, no significant correlations existed between either cortical area and the basal ganglia areas. correlations were tested between csf and plasma hva and between these fluids and brain regions. the only significan ...19873806086
decalcification end point determination by x-rays and flame photometry to obtain superior quality pulpal sections.radiography and flame photometry have been compared as means of determining the end point of decalcification in relation to minimizing pulp-dentin separation in histological sections of teeth. eighteen homologous pairs of vervet monkey incisor teeth were decalcified in a formic-citric acid mixture. at 24 hr intervals decalcification was monitored in half of the teeth by radiography and in the other half by flame photometry. when decalcification was complete as determined by the respective method ...19873307028
prolongation of cardiac xenograft (vervet monkey to baboon) function by a combination of total lymphoid irradiation and immunosuppressive drug therapy. 19873321599
photoreceptor fine structure in the vervet monkey (cercopithecus aethiops).the structure of the photoreceptors of the vervet monkey (cercopithecus aethiops) has been investigated by light and electron microscopy. in this species the photoreceptors can be readily differentiated and adequately described by the classical terminology of rods and cones, with rods being the more numerous. rods are long, slender cells while cones are shorter and stouter. both rods and cones are highly differentiated cells and consist of an outer segment, a connecting cilium, and inner segment ...19872980747
comparison of ketamine, physical restraint, halothane and pentobarbital: lack of influence on serotonergic measures in monkeys and rats.the consequences of the use of ketamine for immobilization have been examined on the concentration of whole blood serotonin, concentrations of neurotransmitters and metabolites in csf and brain, and specific binding of ligands related to neurotransmitters in brain. vervet monkeys (cercopithecus aethiops sabaeus) were examined under conditions which compared ketamine with physical restraint and with halothane. it was found that ketamine, used acutely in monkeys for restraint, had no influence on ...19873431664
the effect of raising or lowering tryptophan levels on aggression in vervet monkeys.social groups of vervet monkeys (cercopithecus aethiops) were given amino acid mixtures that were tryptophan-free (t-), nutritionally balanced (b), or contained excess tryptophan (t+). the t- mixture caused a marked decrease in plasma tryptophan and the t+ mixture a large increase. behavioral observations were made on the animals after administration of the amino acid mixtures both during spontaneous activity and while the (fasted) animals were competing for food newly placed in the feeder. the ...19873432316
isolation of leishmania major from a naturally infected vervet monkey (cercopithecus aethiops) caught in kiambu district, kenya. 19873437365
a histometric/scanning electron microscope study of normal and loaded oral epithelium of the vervet monkey.to investigate the functional significance of the epithelial cell surface features found in oral mucosa, a histometric analysis of the pits, microvilli and microplications was carried out in normal and mechanically loaded attached gingiva and alveolar mucosa of the vervet monkey throughout the full thickness of the epithelium. an electronic image analysing system and point counting methods were used to obtain the necessary data from micrographs of tissue specimens viewed in the scanning electron ...19873446668
diets realistic for westernized people significantly effect lipoproteins, calcium, zinc, vitamins c, e, b6 and haematology in vervet monkeys.this report describes measurements of 50 variables in adult, female, reproductively inactive vervet monkeys during prolonged nutrition realistic for westernized people. dietary treatments consisted of an atherogenic western diet (wd) and a prudent western diet (pd). ingredients were normal foods for man and no extra cholesterol was added. fortification of both diets with vitamin c after cooking was necessary to prevent deficiency. randomised groups of vervet monkeys received either the pd or wd ...19873632758
the influence of diet and dimethylhydrazine on the large intestine of vervet monkeys: scanning and transmission electron microscope studies.the study was designed to identify diet and carcinogen-dependent ultrastructural changes in the epithelium of macroscopically normal colonic mucosa in primates. seventy adult female vervet monkeys were divided into seven equal treatment groups. four received a western high-fat low fibre diet (wd), two a prudent low-fat higher fibre diet (pd) and one a control low-fat high fibre diet (cd). three groups (2 wd, 1 pd) received dimethylhydrazine intramuscularly at 14 day intervals. after 18 months, m ...19873620336
toward a theory for the evolution of cultural communication: coevolution of signal transmission and reception.a haploid sexual two-locus model of gene-culture coevolution is examined, in which a dichotomous phenotype subject to natural selection is transmitted vertically with probabilities dependent on the chosen parent's genotype and phenotype and the offspring's genotype. stability conditions for the genetically monomorphic corner equilibria are obtained. in a specialization of this general model, one locus controls the transmission and the other controls the reception of adaptive information. the cor ...19873478689
promotion and regression of atherosclerosis in vervet monkeys by diets realistic for westernized people.we have described and measured aortic and arterial atherosclerosis in adult female vervet monkeys (n = 61) after application of dietary treatments for 47 months. the diets were compounded entirely of normal food items for westernized people, with no extra cholesterol added. a 'western' diet (wd), known to induce hypercholesterolaemia, was found to be atherogenic in aortas and some arteries. a more 'prudent' diet (pd) induced much less lipid infiltration into aortic intimas and was not associated ...19873632759
similarity of 5-ht2 receptor sites in dominant and subordinate vervet monkeys.pharmacological studies using serotonergic agents have revealed status-linked behavioral effects in dominant and subordinate vervet monkeys. a possible explanation for the greater drug response observed in dominant animals is that there is a cns difference between dominant and subordinate animals. such differences could exist at the level of serotonin receptor sites, membrane responsiveness, or interaction with other neurotransmitters. we have examined the specific 3h-ketanserin binding in vario ...19873659094
fixation of vervet monkey oral mucosa for ultrastructural investigation--tem.this study was undertaken to determine optimal fixation procedure for vervet monkey (cercopithecus pygerythrus) oral mucosa. perfusion and immersion fixation were investigated using glutaraldehyde and glutaraldehyde-paraformaldehyde fixatives with either a phosphate or sodium cacodylate buffer as vehicle and with osmolarities varying from 2010 to 320 mosm. good fixation could not be obtained uniformly or consistently by perfusion. vervet monkey oral mucosa is best fixed by first perfusing the he ...19873321568
differential behavioral effects of tryptophan and 5-hydroxytryptophan in vervet monkeys: influence of catecholaminergic systems.in previous studies tryptophan and 5-hydroxy-tryptophan (5-htp) treatments produced opposite effects on aggression and vigilance and differing effects on eating and locomoting in vervet monkeys. this study examined the effects of the serotonin reuptake inhibitor fluoxetine, and the catecholamine reuptake inhibitor desmethylimipramine (dmi) on tryptophan and 5-htp induced behavioral changes. thirty-two adult males from 16 different social groups were studied. tryptophan (10, 20, and 40 mg/kg/day) ...19873114814
selection of secondary growth areas by vervet monkeys (cercopithecus aethiops).habitat selection by a group of vervet monkeys (cercopithecus aethiops) living on the savanna peninsula of st. kitts was investigated by the intensive sampling of 12 transects. the vervets exhibited nonrandom use of habitats. examination of 20 ecological variables in each of the habitat types revealed that the vervets preferentially used areas of secondary growth characterized by high density and diversity of tall food plants. it is suggested that the preferential use of secondary growth habitat ...198731973510
pregnancy outcome in free-ranging vervet monkeys (cercopithecus aethiops).a preliminary assessment of individual female differences in conception rate and fetal wastage has been determined for a population of wild vervet monkeys (cercopithecus aethiops). one of three troops of vervet monkeys, the subjects of a long-term behavioral study, was trapped and blood was obtained for electrophoretic analysis. pregnant females exhibited a distinctive serum aminopeptidase phenotype allowing a conclusive determination of pregnancy. of the seven females diagnosed as pregnant, thr ...198731973506
terrestrial locomotion and back anatomy in vervets (cercopithecus aethiops) and patas monkeys (erythrocebus patas).this comparative study addressed the problem of relationships between locomotor behavior and back anatomy in the cursorial monkeys, cercopithecus aethiops and erythrocebus patas. analysis of cine-film revealed that patas and vervet monkeys differed significantly in the degree to which they used their backs to increase stride length during galloping. c. aethiops showed increased ranges of sagittal back motion as galloping speed increased almost fivefold; e. patas failed to show significant increa ...198731973464
effects of trapping on the vervet (cercopithecus aethiops sabaeus) population in barbados.the effects of a 7-year trapping program on a population of vervets, cercopithecus aethiops sabaeus, in barbados is described. the pretrapping population was estimated at between 6,000 and 12,000 monkeys. the number trapped annually has increased from less than 200 in 1980 to almost 1,000 in 1986. despite this, annual catch per trapping effort indicates that population abundance has remained relatively constant. however, the proportion of juveniles to adults in the population has increased marke ...198831968894
plasma low density lipoprotein composition in relation to atherosclerosis in nutritionally defined vervet monkeys.an atherogenic diet (ad) consisting entirely of normal foods for westernized people was fed to female vervet monkeys for 4 years. the plasma low density lipoprotein (ldl) cholesterol pool was increased and progression of atherosclerosis was enhanced by the ad compared to a more prudent western diet. the increased ldl-cholesterol was carried by a 3-fold increase in particles of relatively normal composition and not by packing cholesterol esters into the cores of enlarged ldl particles, as has bee ...19883145748
long-term effects of early mothering behavior on responsiveness to the environment in vervet monkeys.the long-term effect of early mothering style on juvenile responsiveness to the external environment was studied in vervet monkeys living in two naturally composed, undisturbed social groups. mothering behavior for 35 mother-infant dyads was analyzed by principal components analysis which revealed two independent dimensions: protectiveness and rejection. protectiveness was characterized by high levels of approach, making contact, restraint, and inspection from mother to infant, and rejection was ...19883234602
plasma endotoxin concentration in healthy primates and during e. coli-induced shock.the normal range for circulating plasma endotoxin concentration was determined in 62 healthy primates (vervet monkeys, cerecopithecus aethiops) by the chromogenic substrate modification of the limulus amoebocyte lysate test, and found to have a mean of 0.076 +/- 0.004 ng/ml (range 0.000 to 0.0127). four anesthetized primates received an ld100 iv infusion of escherichia coli over one hour. plasma concentrations of endotoxin (lipopolysaccharide, lps) and anti-lps igg, and viable e. coli colonies i ...19883286118
evidence of blood cerebrospinal fluid barrier permeability impairment in trypanosoma rhodesiense infection in vervet monkeys.blood-cerebrospinal fluid (csf) barrier damage in 11 vervet monkeys was estimated before infection and during the early and late phases of trypanosoma rhodesiense disease, using the method given by tibbling, link and ohman (1977). of the 11, only one monkey showed signs of barrier impairment that ranged from a slight (12.6) to total barrier impairment (285); the latter occurring just before the height of clinical encephalitis. the barrier reverted to normal after melarsoprol treatment at 1.8 mg/ ...19883197248
the effect of breakfast on social behavior and brain amine metabolism in vervet monkeys.two groups of vervet monkeys were fed, on alternate days, either before or after a morning observation period. this enabled us to determine changes in behavior when the animals were fed a nutritionally balanced breakfast of monkey chow. feeding did not alter the proportion of behaviors that were social or non-social, but had a marked effect on individual behaviors. feeding increased active behaviors among the adult animals except for the vervets who were lowest in the social hierarchy in each ca ...19883353416
the acoustic features of vervet monkey alarm calls.vervet monkeys routinely produce semantic alarm calls upon detection of various predators encountered in their natural environment. two of these calls, snake and eagle alarms, were analyzed using digital signal processing techniques in order to identify potentially distinctive acoustic cues. distinctive cues were sought in the periodicity of the source waveform associated with each call type, the probable vocal tract filtering functions, and in temporal patterning. results were equivocal with re ...19883403806
serodiagnosis of african sleeping sickness in vervet monkeys by detection of parasite antigens.sera of vervet monkeys experimentally infected with t. b. rhodesiense were examined using a double antibody sandwich elisa and procyclic agglutination trypanosomiasis test (patt) for the presence of circulating trypanosomal antigens and anti-procyclic surface antibodies, respectively. trypanosomal antigens were detected at 7 days post infection and remained at a detectable level thereafter during the infection. antigens were not detected in sera prior to experimental infection or at 26 days afte ...19882907259
effects of dietary fiber in vervet monkeys fed "western" diets.male vervet monkeys (7/treatment) were fed a "western" diet containing 46.2% calories as fat, 39.8% as carbohydrate and 14.0% as protein. the diet was augmented with 10% cellulose or 10% pectin. a third (control) group of seven monkeys was fed a commercial ration augmented with fruit and bread. after 34 weeks, serum cholesterol levels were elevated significantly in the two test groups compared with the controls but there was no difference between the two fiber-fed groups. serum triglycerides wer ...19882836687
hepatic estrogen-binding proteins in male and female vervet monkeys.hepatic cytosols from male and female vervet monkeys (cercopithecus pygerythrus) were found to contain the same levels of high affinity estrogen-binding proteins. multipoint saturation analyses revealed that male liver cytosols contain two distinctly different binding components: a high affinity (haeb) and a low affinity estrogen binder (laeb). female livers appeared to contain only the haeb. sucrose density gradient (sdg) analyses, however, clearly established the presence of a 3.8 s as well as ...19883419161
absolute auditory thresholds in three old world monkey species (cercopithecus aethiops, c. neglectus, macaca fuscata) and humans (homo sapiens).we investigated the absolute auditory sensitivities of three monkey species (cercopithecus aethiops, c. neglectus, and macaca fuscata) and humans (homo sapiens). results indicated that species-typical variation exists in these primates. vervets, which have the smallest interaural distance of the species that we tested, exhibited the greatest high-frequency sensitivity. this result is consistent with masterton, heffner, and ravizza's (1969) observations that head size and high-frequency acuity ar ...19883396316
morphology and morphometry of the normal lung of the adult vervet monkey (cercopithecus aethiops).the lungs of four adult specimens of the vervet monkey (cercopithecus aethiops) have been examined by transmission and scanning electron microscopy. a morphometric evaluation of the structural components directly involved in gas exchange has been carried out and the data have been modelled to estimate the anatomical diffusing capacity of the lung. the upper air-conducting airways of the lung were lined by an epithelium characterized by ciliated cells among which were dispersed goblet cells. the ...19883213831
the effect of altered tryptophan levels on mood and behavior in normal human males.the effect of lowering or raising tryptophan levels was studied in normal males using amino acid mixtures that were tryptophan free or tryptophan supplemented. tryptophan depletion caused a small but significant alteration in food selection in subjects allowed to select from a buffet. although carbohydrate and total kilocalories selected were unchanged, significantly less protein was chosen. tryptophan depletion also caused an acute lowering of mood, suggesting that low serotonin (5-ht) may be i ...19883052819
retinal epithelial fine structure in the vervet monkey (cercopithecus aethiops).the morphology of the retinal pigment epithelium (rpe) and closely associated bruch's membrane (complexus basalis) and choriocapillaris have been investigated by electron microscopy in the vervet monkey (cercopithecus aethiops). the rpe is composed of a single layer of cuboidal cells joined laterally by apically-located junctional complexes. basally (sclerally) these cells display numerous infoldings while apically (vitreally) abundant processes enclose and interdigitate with rod outer segments. ...19882980205
effect of a topical drug combination on the early healing of extraction sockets in the vervet monkey.an animal trial was undertaken in 9 vervet monkeys to test the effect of a medicament combination on extraction socket healing. all 4 third molar teeth were extracted and 2 of the sockets in each animal were packed with gelfoam sponge impregnated with a medicament containing a local anaesthetic, antiseptic, 2 potent antifibrinolytic agents and metronidazole. the remaining 2 sockets acted as controls: one of the sockets was packed with gelfoam sponge alone and the other allowed to heal spontaneou ...19883133425
preliminary studies on toxic effects of cyclopiazonic acid alone and in combination with aflatoxin b1 in non-human primates.results of experimental studies on toxicity of cyclopiazonic acid (cpa), a mycotoxin isolated from aspergillus flavus, and toxicity of this toxin in combination with aflatoxin b1 (afb1) are reported. experiments were conducted in 16 vervet monkeys of both sexes. one male monkey was given 1 mg/kg per day of cpa intragastrically and the dose was doubled every third day to eventually achieve 60 mg/kg per day. two males and 3 female monkeys were fed 20 mg/kg per day of cpa and terminated after 60 an ...19883142106
allotransplantation and autotransplantation of mature teeth in monkeys: the influence of endodontic treatment.this study investigated the effect of endodontic treatment on root resorption of autotransplanted and allotransplanted mature teeth in unmatched monkeys. the material comprised 40 mature maxillary central incisors in 20 green vervet monkeys (cercopithecus aethiops). teeth were either allotransplanted or autotransplanted in pairs of monkeys matched only for the size of the root. endodontic treatment was performed at random peroperatively with gutta percha and kerr sealer in 10 of each of the 20 a ...19883165121
low density lipoprotein kinetics in african green monkeys showing variable cholesterolaemic responses to diets realistic for westernised people.african green (vervet) monkeys were fed either an atherogenic western diet (wd), a prudent diet (pd), or a high carbohydrate diet (hcd) for various lengths of time. monkeys differed greatly in their response to the wd, and a strong negative correlation was observed between the fractional catabolic rates (fcr) of low density lipoprotein (ldl) and the total plasma cholesterol concentrations (r = -0.83 p = 0.0029). similarly the individual synthetic rates (sr) of ldl plotted against the total plasm ...19883178927
long-term effects of destruction of the endolymphatic sac in a primate species.the endolymphatic sacs of ten vervet monkeys were surgically ablated unilaterally, and the animals were assigned predetermined survival times ranging from 6 months to 5 years. the left and right ears were prepared in anatomical continuity for light microscopic study. four experimental ears had openings in their membranous labyrinths of unknown etiology and were not considered acceptable for correlative studies. the remaining five experimental ears showed mild cochlear endolymphatic hydrops, whic ...19883185072
some histological aspects of the hip joint capsule in the vervet monkey.microscopic studies show that the capsule of the hip joint in the vervet monkey (cercopithecus aethiops pygerythrus) is preponderantly collagenous. among the collagen fiber bundles are varying quantities of elastic fibers that demonstrate a definite, differential regional distribution. the highest concentration of elastic tissue is found in the posterior, postero-inferior, and inferior aspects of the hip joint capsule, whereas the anterior and superior aspects of the capsule are preponderantly c ...19883193460
[description of cercopithifilaria verveti n. sp., a subcutaneous filaria of a cercopithecus in kenya].description of the fifth species of cercopithifilaria from african primates. the four previous species are parasites of baboons (papio spp.), this one is a parasite of the vervet monkey (cercopithecus aethiops). the male has yet to be recovered for the new species.19892930121
role of supraspinatus in the quadrupedal locomotion of vervets (cercopithecus aethiops): implications for interpretation of humeral morphology.various researchers have noted that terrestrial and arboreal monkeys often differ in the degree to which the greater tubercle of the humerus projects proximally beyond the profile of the humeral head. these differences have been associated with differing leverage requirements for supraspinatus during quadrupedal locomotion. although jolly (the baboon in medical research, vol. ii., pp. 23-50, 1967) suggested that a projecting tubercle can be related to the ability of supraspinatus to control more ...19892764088
effect of polyunsaturated fat on regression of atheroma in the non-human primate.twenty-seven vervet monkeys were placed on a 'normal' south african diet (polyunsaturated/saturated (p/s) ratio 0.28) for 24 months. nine animals were then sacrificed to obtain a baseline for percentage atheroma in the aorta and iliac vessels (15.7 +/- 3.6%). the remaining animals were divided into two equal groups. group a continued on the diet with a p/s ratio of 0.28, while group b was given the same diet, but with the p/s ratio increased to 1.5. after a further 20 months on their respective ...19892799585
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