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genome characterization of the polyvalent lytic bacteriophage gte2 with the potential for biocontrol of gordonia, rhodococcus and nocardia stabilized foams in activated sludge plants.hydrophobic actinobacteria are commonly associated with the stabilization of foams in activated sludge systems. one possible attractive approach to control these foam stabilizing organisms is to use specific bacteriophages. we describe the genome characterization of a novel polyvalent dna phage, gte2, isolated from activated sludge. this phage is lytic for gordonia terrae, rhodococcus globerulus, rhodococcus erythropolis, rhodococcus erythropolis, nocardia otitididiscaviarum, and nocardia brasil ...201121498753
[microbiological and clinical features of nine cases with nocardial infections].following recent advance in medical technology, the increase of immunocompromised patients results in an increase of opportunistic infections such as nocardiosis. however, little is known about relationships between clinical features of nocardial infections and each nocardia species, especially newly identified ones. therefore, we identified clinical isolates of nocardia species by genetic methods and analyzed clinical features of nocardiosis. nine clinical isolates were obtained in kyushu unive ...201121560401
actinomycetoma of the scalp after a car accident.actinomycetoma is the most frequent type of mycetoma in mexico. localization on the scalp is very rare. because of this topography and potential spread to the brain, the present case became a diagnostic and therapeutic challenge.201121699522
primary pulmonary infection caused by 20% acid fast nocardia brasiliensis. 201122120819
phenotypic and genotypic evaluation of 18 nocardia isolates from human clinical samples in mexico.mexico has the largest number of clinical cases of actinomycetoma in north and south america. species originally identified by less specific methods have been recently reclassified as other known species or as new species.201123177807
diversity and frequency of nocardia spp. in the soil of isfahan province, iran.to isolate and identify nocardia spp. from soil in different regions of isfahan province in the center of iran.201223569953
a life-threatening case of disseminated nocardiosis due to nocardia brasiliensis.nocardiosis is a rare disease caused by infection with nocardia species, aerobic actinomycetes with a worldwide distribution. a rare life-threatening disseminated nocardia brasiliensis infection is described in an elderly, immunocompromised patient. microorganism was recovered from bronchial secretions and dermal lesions, and was identified using molecular assays. prompt, timely diagnosis and appropriate treatment ensured a favorable outcome.201223559737
[primary cutaneous nocardia brasiliensis cellulitis in immunocompetent child].primary cutaneous nocardiosis is an infrequent infection among children, generally affecting immunocompromised hosts. it is caused by gram positive bacteria, partially alcohol and acid resistant which are saprophytes of the soil, water and organic matter. in most cases the causal agent enters through inhalation, and hematogenous dissemination may occur mainly among the immune compromised patients. direct cutaneous inoculation is less frequent, especially among children. we report an 8-year old f ...201223350294
systemic increased immune response to nocardia brasiliensis co-exists with local immunosuppressive microenvironment.human diseases produced by pathogenic actinomycetes are increasing because they may be present as opportunistic infections. some of these microbes cause systemic infections associated with immunosuppressive conditions, such as chemotherapy for cancer, immunosuppressive therapy for transplant, autoimmune conditions, and aids; while others usually cause localized infection in immunocompetent individuals. other factors related to this increase in incidence are: antibiotic resistance, not well defin ...201222825801
nocardia brasiliensis induces an immunosuppressive microenvironment that favors chronic infection in balb/c mice.nocardia brasiliensis is an intracellular microorganism and the most common etiologic agent of actinomycetoma in the americas. several intracellular pathogens induce an immunosuppressive microenvironment through increases in cd4+ foxp3+ regulatory t cells (treg), thus downregulating other t-cell subpopulations and assuring survival in the host. in this study, we determined whether n. brasiliensis modulates t-lymphocyte responses and their related cytokine profiles in a murine experimental model. ...201222547544
complete genome sequence of nocardia brasiliensis hujeg-1.in mexico, actinomycetoma is mainly caused by nocardia brasiliensis, which is a soil inhabitant actinobacterium. here, we report for the first time the draft genome of a strain isolated from a human case that has largely been found in in vitro and experimental models of actinomycetoma, n. brasiliensis hujeg-1.201222535940
in vitro activities of the new antitubercular agents pa-824 and btz043 against nocardia brasiliensis.the in vitro activity of pa-824 and btz043 against 30 nocardia brasiliensis isolates was tested. the mic(50) and mic(90) values for pa-824 were both >64 μg/ml. the same values for btz043 were 0.125 and 0.250 μg/ml. given the mic values for benzothiazinone (btz) compounds, we consider them good candidates to be tested in vivo against n. brasiliensis.201222526312
nocardia harenae, an uncommon causative organism of mycetoma: report on two patients.mycetoma is the most frequently diagnosed deep mycosis in mexico and is caused, in 86% of cases, by nocardia brasiliensis. worldwide, nocardia harenae has not been previously reported as a causative agent of human mycetoma. herein we report, to our knowledge, the first two human cases of mycetoma due to n. harenae in a clinical setting. the strains were identified by phenotypic and molecular techniques. both cases were characterized by long-lasting mycetoma that had previously been failed to be ...201222499778
uncommon mandibular osteomyelitis in a cat caused by nocardia africana.nocardiosis is an unusual infection in companion animals characterized by suppurative to pyogranulomatous lesions, localized or disseminated. cutaneous-subcutaneous, pulmonary and systemic signs are observed in feline nocardiosis. however, osteomyelitis is a rare clinical manifestation in cats. nocardia cyriacigeorgica (formerly n. asteroides sensu stricto), nocardia brasiliensis, nocardia otitidiscaviarum, and nocardia nova are the most common pathogenic species identified in cats, based on rec ...201223216681
nocardia brasiliensis cell wall lipids modulate macrophage and dendritic responses that favor development of experimental actinomycetoma in balb/c mice.nocardia brasiliensis is a gram-positive facultative intracellular bacterium frequently isolated from human actinomycetoma. however, the pathogenesis of this infection remains unknown. here, we used a model of bacterial delipidation with benzine to investigate the role of n. brasiliensis cell wall-associated lipids in experimental actinomycetoma. delipidation of n. brasiliensis with benzine resulted in complete abolition of actinomycetoma without affecting bacterial viability. chemical analyses ...201222851755
[ocular disease as an onset form of disseminated nocardiosis by nocardia brasiliensis]. 201222571846
primary cutaneous nocardia brasiliensis infection isolated in an immunosuppressed patient: a case report.cutaneous nocardiosis is a rare infection that may manifest as a superficial skin lesion, lymphocutaneous infection, mycetoma, or diffuse cutaneous infection from a disseminated systemic infection. we report a case of a 65-year-old immunocompromised man with persistent primary cutaneous nocardia brasiliensis infection following a motor vehicle collision. a high degree of suspicion is needed to diagnose nocardia infection because of its resemblance to other bacterial infections. nocardiosis shoul ...201222474729
multisite reproducibility of the broth microdilution method for susceptibility testing of nocardia species.antimicrobial susceptibility testing (ast) of clinical isolates of nocardia is recommended to detect resistance to commonly used antimicrobial agents; such testing is complicated by difficulties in inoculum preparation and test interpretation. in this study, six laboratories performed repetitive broth microdilution testing on single strains of nocardia brasiliensis, nocardia cyriacigeorgica, nocardia farcinica, nocardia nova, and nocardia wallacei. for each isolate, a total of 30 microdilution p ...201222219309
nocardia brasiliensis infection mimicking juvenile idiopathic arthritis in a 4-year-old girl.nocardia are ubiquitous environmental saprophytes that cause pneumonia and disseminated disease in immunocompromised patients. they can also cause localized cutaneous and soft tissue infections in healthy people after direct percutaneous inoculation. nocardia arthritis is rare in both forms of the disease. here we present the first published case of a child with septic arthritis caused by n brasiliensis. importantly, this otherwise well 4-year-old girl had no known history of trauma but presente ...201324127474
[subcutaneous abscess due to nocardia brasiliensis identified by mass spectrometry]. 201323895743
retnla down-regulation and il-13-rich environment correlate with inflammation severity in experimental actinomycetoma by nocardia brasiliensis.nocardia brasiliensis (nb) is a facultative intracellular pathogen that may cause actinomycetoma when immune response is unable to control the pathogenic invasion. we used comparative real-time pcr to evaluate the expression level of molecules indicative of either classical or alternative activation of macrophages, as well as of cytokines involved in macrophage polarization, during the experimental infection in balb/c mice. we found induction or increased expression of the pro-inflammatory marke ...201323620185
nocardia brasiliensis vertebral osteomyelitis and epidural abscess.nocardia species exist in the environment as a saprophyte; it is found worldwide in soil and decaying plant matter. they often infect patients with underlying immune compromise, pulmonary disease or history of trauma or surgery. the diagnosis of nocardiosis can be easily missed as it mimics many other granulomatous and neoplastic disease. we report a 69-year-old man who presented with chronic back pain and paraparesis. he was found to have nocardial brasiliensis vertebral osteomyelitis and epidu ...201323585503
nocardia brasiliensis endophthalmitis in a patient with an exposed ahmed glaucoma drainage implant.to report a case of endophthalmitis due to nocardia brasiliensis in an eye with an exposed, infected ahmed glaucoma drainage implant (gdi).201323323584
nocardia abscessus brain abscess in an immunocompetent host.nocardia brain abscesses typically occur in immunocompromised patients. most cases of nocardiosis are caused by the nocardia asteroides complex and nocardia brasiliensis. here, we present a patient with a nocardia abscessus brain abscess. the diagnosis was confirmed by dna sequencing, and the organism was susceptible to linezolid, clarithromycin, ceftriaxone, imipenem, tobramycin, amikacin, minocycline and sulfamethoxazole. the patient was successfully treated medically in combination with surgi ...201323668458
the incidence of nocardiosis at pulmonary and extra - pulmonary sites.nocardiosis is a rare but well-established opportunistic infection. we are presenting two cases of nocardiosis diagnosed in the microbiology laboratory, one in an immuno-competent elderly patient and the other in a immunocompromised patient with aids. the first case was of pulmonary nocardiosis which was caused by the nocardia asteroides complex and concomitant infections with staphylococcus aureus and blastoschizomyces capitatus. in the second case, nocardia brasiliensis was isolated from the p ...201323998082
cutaneous manifestations of nocardia brasiliensis infection in taiwan during 2002-2012-clinical studies and molecular typing of pathogen by gyrb and 16s gene sequencing.to observe the clinicopathologic and resistance profiles of the nocardia brasiliensis causing cutaneous nocardiosis in taiwan, 12 n. brasiliensis isolates were prospectively collected from patients with cutaneous nocardiosis in a hospital during 2002-2012. clinicopathologic data were obtained, and isolates were identified by biochemical methods and 16s rrna sequencing. susceptibilities to 14 antimicrobial compounds were tested. isolates were further genotyped by sequencing of 16s rrna, seca1, hs ...201323791388
cutaneous nocardiosis in two dogs receiving ciclosporin therapy for the management of canine atopic dermatitis.ciclosporin is a calcineurin inhibitor that is currently registered for the treatment of canine atopic dermatitis. the most common adverse effects include mild, transient gastrointestinal disturbances. single case reports of opportunistic infections due to nocardia spp., neospora spp. and papillomaviruses have also been reported.201323781943
complete genome sequence analysis of nocardia brasiliensis hujeg-1 reveals a saprobic lifestyle and the genes needed for human pathogenesis.nocardia brasiliensis is an important etiologic agent of mycetoma. these bacteria live as a saprobe in soil or organic material and enter the tissue via minor trauma. mycetoma is characterized by tumefaction and the production of fistula and abscesses, with no spontaneous cure. by using mass sequencing, we determined the complete genomic nucleotide sequence of the bacteria. according to our data, the genome is a circular chromosome 9,436,348-bp long with 68% g+c content that encodes 8,414 protei ...201323755230
the first korean case of disseminated mycetoma caused by nocardia pseudobrasiliensis in a patient on long-term corticosteroid therapy for the treatment of microscopic polyangiitis.nocardia pseudobrasiliensis is predominantly associated with invasive infections in immunocompromised patients. we report a case of disseminated mycetoma caused by n. pseudobrasiliensis in a 57-yr-old woman with microscopic polyangiitis, who was treated for 3 months with corticosteroids. the same organism was isolated from mycetoma cultures on the patient's scalp, right arm, and right leg. the phenotypic characteristics of the isolate were consistent with both nocardia brasiliensis and n. pseudo ...201323667849
emergence of co-trimoxazole resistant nocardia brasiliensis causing fatal pneumonia.an 85-year-old man was admitted to the medical intensive care unit with a 10-day history of severe breathlessness, fever and cough. the patient was known to have chronic obstructive pulmonary disease and had been receiving corticosteroids in the preceding 18 months. he had been treated for tuberculosis 2.5 years previously. on examination he was febrile, tachycardic with a respiratory rate of 46/min. auscultation revealed bilateral crepitation's and wheeze. chest radiograph revealed patchy infil ...201323598938
global burden of human mycetoma: a systematic review and meta-analysis.mycetoma is a chronic infectious disease of the subcutaneous tissue with a high morbidity. this disease has been reported from countries between 30°n and 15°s since 1840 but the exact burden of disease is not known. it is currently unknown what the incidence, prevalence and the number of reported cases per year per country is. in order to estimate what the global burden of mycetoma is, a meta-analysis was performed. in total 50 studies were included, which resulted in a total of 8763 mycetoma ca ...201324244780
identification of fluorinases from streptomyces sp ma37, norcardia brasiliensis, and actinoplanes sp n902-109 by genome mining.the fluorinase is an enzyme that catalyses the combination of s-adenosyl-l-methionine (sam) and a fluoride ion to generate 5'-fluorodeoxy adenosine (fda) and l-methionine through a nucleophilic substitution reaction with a fluoride ion as the nucleophile. it is the only native fluorination enzyme that has been characterised. the fluorinase was isolated in 2002 from streptomyces cattleya, and, to date, this has been the only source of the fluorinase enzyme. herein, we report three new fluorinase ...201424449539
[update on the epidemiology of mycetoma in mexico. a review of 3933 cases].mycetoma is one of the most frequent chronic subcutaneous infections in many tropical and subtropical regions.201424108347
genome based analysis of type-i polyketide synthase and nonribosomal peptide synthetase gene clusters in seven strains of five representative nocardia species.actinobacteria of the genus nocardia usually live in soil or water and play saprophytic roles, but they also opportunistically infect the respiratory system, skin, and other organs of humans and animals. primarily because of the clinical importance of the strains, some nocardia genomes have been sequenced, and genome sequences have accumulated. genome sizes of nocardia strains are similar to those of streptomyces strains, the producers of most antibiotics. in the present work, we compared second ...201424884595
thyrotoxicosis followed by hypothyroidism due to suppurative thyroiditis caused by nocardia brasiliensis in a patient with advanced acquired immunodeficiency syndrome.acute thyroiditis is an extremely rare complication of nocardiosis. we report a patient with hyperthyroidism due to suppurative thyroiditis caused by nocardia brasiliensis. a 38-year-old black male presented with features of thyrotoxicosis, sepsis and airway obstruction. he had no evidence of underlying thyroid disease, but was severely immunocompromised as a result of acquired immunodeficiency syndrome. he had previously been diagnosed with pulmonary nocardiosis and also had nocardial abscesses ...201424847469
characterization of a sam-dependent fluorinase from a latent biosynthetic pathway for fluoroacetate and 4-fluorothreonine formation in nocardia brasiliensis.fluorination has been widely used in chemical synthesis, but is rare in nature. the only known biological fluorination scope is represented by the fl pathway from streptomyces cattleya that produces fluoroacetate (fac) and 4-fluorothreonine (4-ft). here we report the identification of a novel pathway for fac and 4-ft biosynthesis from the actinomycetoma-causing pathogen nocardia brasiliensis atcc 700358. the new pathway shares overall conservation with the fl pathway in s. cattleya. biochemical ...201424795808
atomic force microscopy in biofilm study.biofilms have been classically visualized by scanning electron microscopy (sem). the complex operating procedure of sem restricts its use in routine practice. there is a need of newer visualizing techniques for examining surfaces of biofilms, in particular under ambient conditions. we have presented the unique advantages of atomic force microscopy (afm) in studying surfaces of biofilms through analyses of the height images obtained on biofilms of two gram positive and one gram negative bacteria, ...201424793174
corneal ulcer caused by nocardia brasiliensis in a patient with diabetes. 201424790888
[case of the abscess type cutaneous nocardiosis].a 58-year-old woman, who had write infull (itp) and angina, developed a rash similar to an insect bite on the left achilles tendon one week before visiting our hospital. the rash evolved into pustule. three or 4 days later she had redness and swelling on her left leg, which was pain full.she went to a clinic, where she was given cefdinir (cfdn) and referred to our hospital.when she came to our hospital, she had an abscess on her left heel, and linear redness and heat along lymph ducts in her lef ...201424682099
soil-acquired cutaneous nocardiosis on the forearm of a healthy male contracted in a swamp in rural eastern virginia.a 45-year-old man complained of pain and swelling on his right wrist after receiving a scratch while playing paintball in a swampy area of eastern virginia. two weeks later, he noticed a pimple-like lesion developing, which quickly grew in size and then ulcerated. because of the severity of his condition, the patient was taken to the emergency room where surgical drainage of the abscess was carried out and the pus was sent for culture and sensitivity testing. enlarged and tender lymph nodes were ...201424634589
mycetoma: experience of 482 cases in a single center in mexico.mycetoma is a chronic granulomatous disease. it is classified into eumycetoma caused by fungi and actinomycetoma due to filamentous actinomycetes. mycetoma can be found in geographic areas in close proximity to the tropic of cancer. mexico is one of the countries in which this disease is highly endemic. in this retrospective study we report epidemiologic, clinical and microbiologic data of mycetoma observed in the general hospital of mexico in a 33 year-period (1980 to 2013). a total of 482 case ...201425144462
nocardia vulneris sp. nov., isolated from wounds of human patients in north america.nocardia species are ubiquitous in the environment with an increasing number of species isolated from clinical sources. from 2005 to 2009, eight isolates (w9042, w9247, w9290, w9319, w9846, w9851t, w9865, and w9908) were obtained from eight patients from three states in the united states and canada; all were from males ranging in age from 47 to 81 years old; and all were obtained from finger (n = 5) or leg (n = 3) wounds. isolates were characterized by polyphasic analysis using molecular, phenot ...201425015412
nocardia brasiliensis induces formation of foamy macrophages and dendritic cells in vitro and in vivo.foamy cells have been described in various infectious diseases, for example in actinomycetoma induced by nocardia brasiliensis. these cells are generally considered to be macrophages, although they present dendritic cell (dc)-specific surface markers. in this study, we determined and confirmed the lineage of possible precursors of foamy cells in vitro and in vivo using an experimental actinomycetoma model in balb/c mice. bone marrow-derived macrophages (bmdm) or dc (bmdc) were infected in vitro ...201424936860
immunomodulatory effect of diethylcarbamazine in mice infected with nocardia brasiliensis.we tested whether diethylcarbamazine (dec) or ivermectin (ivm), both antiparasitic drugs with reported immunomodulatory properties, were able to affect the immune system to potentiate host defense mechanisms and protect against actinomycetoma in a mouse model. male balb/c mice of 10-12 weeks of age were injected with either nocardia brasiliensis or saline solution. recorded were the effects of a treatment by dec (6 mg/kg per os daily for one week) or ivm (200 μg/kg subcutaneously on days 1 and 3 ...201425150175
mycetoma caused by nocardia brasiliensis in an immunocompetent patient. 201425135693
comparative genomic analyses reveal a lack of a substantial signature of host adaptation in rhodococcus equi ('prescottella equi').rhodococcus equi ('prescottella equi') is a pathogenic actinomycete primarily infecting horses but has emerged as an opportunistic human pathogen. we have sequenced the genome of the type strain of this species, r. equi strain c7(t) , and compared the genome with that of another foal isolate 103s and of a human isolate atcc 33707. the r. equi strains are closely related to each other and yet distantly related to other rhodococci and nocardia brasiliensis. the comparison of gene contents among r. ...201424376240
nocardia brasiliensis-associated femorotibial osteomyelitis.we report a case of femorotibial osteomyelitis due to nocardia brasiliensis. nocardia spp are a rare cause of bone infections, and the majority of such cases are associated with the spine. this type of osteomyelitis is uncommon, and in the immunocompetent host, is more often related to a chronic evolution following direct inoculation of the microorganism.201424362018
nocardia brasiliensis infection: an emergent suppurative granuloma after mesotherapy. 201423829712
actinomycetoma of the scalp due to nocardia brasiliensis: case report and review of the literature. 201523834435
phylogenetic diversity and antibacterial activity of culturable fungi derived from the zoanthid palythoa haddoni in the south china sea.investigation on diversity of culturable fungi mainly focused on sponges and corals, yet little attention had been paid to the fungal communities associated with zoanthid corals. in this study, a total of 193 culturable fungal strains were isolated from the zoanthid palythoa haddoni collected in the south china sea, of which 49 independent isolates were identified using both morphological characteristics and internal transcribed spacer (its) sequence analyses. thirty-five strains were selected f ...201525117478
in vivo activity of the benzothiazinones pbtz169 and btz043 against nocardia brasiliensis.mycetoma is a neglected, chronic, and deforming infectious disease caused by fungi and actinomycetes. in mexico, n. brasiliensis is the predominant etiologic agent. therapeutic alternatives are necessary because the current drug regimens have several disadvantages. benzothiazinones (btz) are a new class of candidate drugs that inhibit decaprenyl-phosphoribose-epimerase (dpre1), an essential enzyme involved in the cell wall biosynthesis of corynebacterineae.201526474057
sporotrichoid pattern of nerve abscesses in borderline tuberculoid leprosy: a case report (sporotrichoid like abscesses in leprosy).linear distribution of multiple subcutaneous nodules or ulcers along the course of lymphatics, classically seen in lymphocutaneous sporotrichosis, has been observed in a number of other infections like localized cutaneous leishmaniasis, cutaneous tuberculous and non tuberculous mycobacterial infections, pasteurella tularensis, scopulariopsis blochi, nocardia brasiliensis, yaws and syphilis. a case of borderline tuberculoid leprosy with multiple cutaneous nodules corresponding to resolving nerve ...201526411249
actinomycetoma and advances in its treatment.actinomycetoma is a chronic subcutaneous infection caused by aerobic branching actinomycetes. its clinical features are firm tumefaction of the affected site and the presence of abscesses, nodules, and sinuses that drain a seropurulent exudate containing filamenting granules. the disease is caused by inoculation of the infectious agent through minor trauma in susceptible individuals. nocardia brasiliensis, actinomadura madurae, and streptomyces somaliensis are among the most frequent agents in t ...201522682184
antagonistic activity of nocardia brasiliensis ptcc 1422 against isolated enterobacteriaceae from urinary tract infections.the main drawback of current antibiotic therapies is the emergence and rapid increase in antibiotic resistance. nocardiae are aerobic, gram-positive, catalase-positive, non-motile actinomycetes. nocardia brasiliensis was reported as antibiotic producer. the purpose of the study was to determine antibacterial activity of n. brasiliensis ptcc 1422 against isolated enterobacteriaceae from urinary tract infections (utis). the common bacteria from utis were isolated from hospital samples. antimicrobi ...201626920557
target-specific identification and characterization of the putative gene cluster for brasilinolide biosynthesis revealing the mechanistic insights and combinatorial synthetic utility of 2-deoxy-l-fucose biosynthetic enzymes.brasilinolides exhibiting potent immunosuppressive and antifungal activities with remarkably low toxicity are structurally characterized by an unusual modified 2-deoxy-l-fucose (2df) attached to a type i polyketide (pk-i) macrolactone. from the pathogenic producer nocardia terpenica (nocardia brasiliensis ifm-0406), a 210 kb genomic fragment was identified by target-specific degenerate primers and subsequently sequenced, revealing a giant nbr gene cluster harboring genes (nbrcdef) required for t ...201626754528
nocardiajiangsuensis sp. nov., an actinomycete isolated from coastal soil.a novel actinomycete strain, designated strain klbmp s0027t, was isolated from a coastal soil collected from the coastal region of lianyungang, jiangsu province, in east china, and was studied in detail for its taxonomic position. comparative 16s rrna gene sequence analysis showed that this strain belonged to the genus nocardia and was most closely related to nocardia harenae ws-26t (98.5 %), nocardiaasiatica nbrc 100129t (98.5 %), nocardiaabscessus nbrc 100374t (98.2 %), nocardia brasiliensis n ...201627503503
genomic changes associated with the loss of nocardia brasiliensis virulence in mice after 200 in vitro passages.nocardia species, particularly nocardia brasiliensis, are etiologic agents of mycetoma, a chronic subcutaneous infection. until now, little has been known about the pathogenic mechanisms involved in nocardial infection. traditionally, subculture in rich media has been a simple way to induce attenuation. in this work, we report the changes in virulence toward mice and in genomic constitution of n. brasiliensis produced after 200 continuous subcultures in brain heart infusion (bhi) medium (p-200 s ...201627354446
a case of an immunocompetent young man obtaining community-acquired disseminated nocardia brasiliensis.nocardiosis is a rare but severe pyogenic or granulomatous disease and caused by nocardia that mainly infects immunocompromised patients. we report here a case of an immunocompetent 24-year-old male student with community-acquired pneumonia with asymptomatic disseminated cerebral abscess by brasiliensis nocardiosis. the patient was fully recovered after receiving optimized antimicrobial therapy without relapse. this case suggests the health professionals such as the physicians of pulmonary, infe ...201624594251
experimental granulomatous pulmonary nocardiosis in balb/c mice.pulmonary nocardiosis is a granulomatous disease with high mortality that affects both immunosuppressed and immunocompetent patients. the mechanisms leading to the establishment and progression of the infection are currently unknown. an animal model to study these mechanisms is sorely needed. we report the first in vivo model of granulomatous pulmonary nocardiosis that closely resembles human pathology. balb/c mice infected intranasally with two different doses of gfp-expressing nocardia brasili ...201627303806
first case report of nocardia brasiliensis infection causing necrotizing fasciitis in an immunocompetent patient. 201627117138
[one case of nose nocardia brasiliensis infection]. 201627095727
pleural nocardiosis in an immunocompetent patient: a case report.nocardiosis is a rare infection that has attracted attention with its increased rate of occurrence in the recent years. in india there is a rare documentation of the pleural involvement in nocardiosis. we report here a case of pleural nocardiosis caused by nocardia brasiliensis in an immunocompetent patient. this case highlights the importance of considering nocardiosis as a differential diagnosis in patients with pleural lesions.201626894067
successful treatment of primary cutaneous nocardia brasiliensis infection with oral potassium iodide. 201626876145
primary cutaneous nocardiosis in a patient with nephrotic syndrome: a case report and review of the literature.nocardia infection is not common in clinical practice and most cases occur as an opportunistic infection in immunocompromised patients.we report a case of primary cutaneous nocardiosis characterized by multiple subcutaneous abscesses due to nocardia brasiliensis in a patient with nephrotic syndrome undergoing long-term corticosteroid therapy. the patient was diagnosed with nephrotic syndrome 9 months ago, and mesangial proliferative glomerulonephritis was confirmed by renal biopsy. subsequently, ...201626817885
lymphocutaneous nocardiosis caused by nocardia brasiliensis in an immunocompetent elderly woman. 201626475056
systemic nocardia brasiliensis infection in a patient with systemic lupus erythematosus: successful diagnosis and therapy. 201625311703
identification of beta-lactamases and beta-lactam-related proteins in human pathogenic bacteria using a computational search approach.a systematic analysis of beta-lactamases based on comparative proteomics has not been performed thus far. in this report, we searched for the presence of beta-lactam-related proteins in 591 bacterial proteomes belonging to 52 species that are pathogenic to humans. the amino acid sequences for 19 different types of beta-lactamases (act, carb, cifa, cmy, ctx, fox, ges, gob, imp, ind, kpc, len, okp, oxa, oxy, shv, tem, ndm, and vim) were obtained from the arg-annot database and were used to constru ...201728508147
non-coding rnas are differentially expressed by nocardia brasiliensis in vitro and in experimental actinomycetoma.nocardia spp. are common soil-inhabiting bacteria that frequently infect humans through traumatic injuries or inhalation routes and cause infections, such as actinomycetoma and nocardiosis, respectively. nocardia brasiliensis is the main aetiological agent of actinomycetoma in various countries. many bacterial non-coding rnas are regulators of genes associated with virulence factors.201728839491
image gallery: acute primary cutaneous nocardiosis due to nocardia brasiliensis. 201728504394
primary cutaneous nocardiosis caused by nocardia brasiliensis following a wasp sting.we report a case of an 87-year-old woman who presented with painful erythema of her right forearm 10 days after she had been stung by a wasp on her right hand. the lesion had rapidly deteriorated during the week before presentation, and treatment with antibiotics and glucocorticoids did not improve the condition. after careful evaluation, we performed cultures from the lesion aspiration, and morphological and genetic analysis of bacteria cultures confirmed a bacterial infection with nocardia bra ...201728397286
actinomycetoma due to nocardia brasiliensis in tamil nadu.two cases of actinomycetoma caused by nocardia brasiliensis in tamilians are reported. both presented with multiple sinuses discharging serosanguinous material without any granules. in the first case, the lesion was located in the thigh and leg and the specific diagnosis was made by histopathology and isolation of n. brasiliensis. in the other, in addition to thigh and leg, the foot was also affected and the causative agent was isolated in pure culture. the geographic distribution of the organis ...201728193959
review of 21 cases of mycetoma from 1991 to 2014 in rio de janeiro, brazil.mycetoma is caused by the subcutaneous inoculation of filamentous fungi or aerobic filamentous bacteria that form grains in the tissue. the purpose of this study is to describe the epidemiologic, clinic, laboratory, and therapeutic characteristics of patients with mycetoma at the oswaldo cruz foundation in rio de janeiro, brazil, between 1991 and 2014. twenty-one cases of mycetoma were included in the study. there was a predominance of male patients (1.3:1) and the average patient age was 46 yea ...201728192433
epidemiology and susceptibility to antimicrobial agents of the main nocardia species in spain.the aims of this study were to explore the clinical distribution, by species, of the genus nocardia and to assess the antimicrobial susceptibilities of the 10 most prevalent species identified in spain.201727999029
nocardia brasiliensis infection complicating cryptogenic organizing pneumonia.pulmonary nocardiosis is a severe and uncommon opportunistic infection caused by nocardia species. we present a patient with cryptogenic organizing pneumonia who was receiving long-term immunosuppressive therapy, whose treatment course was complicated by cutaneous and pulmonary nocardiosis. tissue cultures confirmed nocardia brasiliensis. nocardiosis should be a diagnostic consideration for patients treated with long-term immunosuppression who have worsening pulmonary symptoms and relapsing pust ...201728348912
actinomycetoma due to nocardia brasiliensis with extension to the ovaries. 201728259373
first case of actinomycetoma in france due to a novel nocardia species, nocardia boironii sp. nov.bacterial mycetoma is a neglected disease mainly observed in tropical area countries and typically associated with rural conditions, making its presence in developed countries of temperate climate areas rare. however, we report the first case of an autochthonous mycetoma case in continental france that originated from a new nocardia species. a gram-positive filamentous bacterium (ofn 14.177(t)) was isolated from a pus sample from the mycetoma of a male french patient 92 years old suffering from ...201727904882
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