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examining trichophyton tonsurans genotype and biochemical phenotype as determinants of disease severity in tinea capitis.trichophyton tonsurans infections occur in various host populations, on various body sites and with varying degrees of inflammation. this investigation was undertaken to determine whether fungal factors could explain the degree of severity in clinical symptomatology among infected children. otherwise healthy children (n=54) presenting with tinea capitis were enrolled in this study. a thorough history was performed, the extent and severity of infection graded and a fungal specimen collected from ...200818404549
epidemiology of sporadic (non-epidemic) cases of trichophyton tonsurans infection in japan based on pcr-rflp analysis of non-transcribed spacer region of ribosomal rna gene.a number of cases of trichophyton tonsurans infection have been reported among sportsmen and women participating in wrestling, judo, and sumo wrestling in japan, but there have also been sporadic reports of cases with no history of contact with these sports. a molecular method using restriction enzyme analysis of pcr-amplified fragments targeting the non-transcribed spacer region (nts) of ribosomal rna gene in fungal nuclei was applied to t. tonsurans strains isolated from sporadic cases in japa ...200818503175
assessment of the treatment protocol described in the guidelines for trichophyton tonsurans infection.infection with the anthropophilic fungus trichophyton tonsurans has spread among members of combat sports clubs and has become a serious public health problem in japan and other countries. infection usually provokes only a weak inflammatory response, and treatment compliance tends to be poor.200818277048
[tinea capitis].tinea capitis is a widespread scalp infection in children caused by dermatophytes. in fact, it is the most common cutaneous mycosis in children but is uncommon in adults. the disease has been major public health concern for decades. some factors implicated in infection include poor personal hygiene, crowded living conditions, and low socioeconomic status. it can be caused by any pathogenic dermatophyte except for epidermophyton floccosum and trichophyton concentricum. trichophyton rubrum, the mo ...200818346430
terbinafine hydrochloride oral granules versus oral griseofulvin suspension in children with tinea capitis: results of two randomized, investigator-blinded, multicenter, international, controlled trials.although griseofulvin is currently considered the primary antifungal agent used to treat tinea capitis in many countries, increasingly higher doses and longer durations of treatment are becoming necessary to achieve effective treatment. alternative antifungal therapies with shorter/simpler treatment regimens may be important to develop for this indication.200818378354
molecular characterization of a squalene epoxidase gene in dermatophyte pathogen trichophyton tonsurans.trichophyton tonsurans is one of the dermatophyte fungi which invades the skin and hair of human. several properties of this fungus have been investigated so far. however a few studies were carried out in the field of molecular biology of this fungus. in the present study, we tried to identify the squalene epoxidase gene which is related to synthesis of ergosterol in this fungus.200818392096
comparison between the standardized clinical and laboratory standards institute m38-a2 method and a 2,3-bis(2-methoxy-4-nitro-5-[(sulphenylamino)carbonyl]-2h-tetrazolium hydroxide- based method for testing antifungal susceptibility of dermatophytes.in this study, we determined the utility of a 2,3-bis(2-methoxy-4-nitro-5-[(sulfenylamino)carbonyl]-2h-tetrazolium hydroxide (xtt)-based assay for determining antifungal susceptibilities of dermatophytes to terbinafine, ciclopirox, and voriconazole in comparison to the clinical and laboratory standards institute (clsi) m38-a2 method. forty-eight dermatophyte isolates, including trichophyton rubrum (n = 15), trichophyton mentagrophytes (n = 7), trichophyton tonsurans (n = 11), and epidermophyton ...200818832129
tinea corporis with acute inflammation caused by trichophyton tonsurans.a 13-year-old japanese boy presented with acute skin inflammation on the extremities. he belonged to a judo club of a junior high school in which club tinea capitis and tinea corporis seemed to be prevalent. vesicles and pustules appeared on his right forearm and right leg. they increased in numbers and formed annular lesions. pruritic erythema appeared surrounding these lesions. direct microscopic examination of the lesions detected hyphae, and culture for the fungi yielded yellowish colonies. ...200818837705
[results of questionnaire survey of trichophyton tonsurans infection in judo clubs registered under the all japan judo federation].it has been seven years since an outbreak of trichophyton tonsurans infection occurred in japan. we have examined the state of t. tonsurans infection by a hairbrush test of athletes and a questionnaire survey of doctors' experience in its treatment, but have not completely grasped the actual state of infection at the sites of judo matches and its treatment or application of preventive measures. subjects and methods: the questionnaire was distributed to the leaders of all judo clubs (10,077 clubs ...200818689970
commonly affected body sites in 92 japanese combat sports participants with trichophyton tonsurans infection.outbreaks of trichophyton tonsurans infection constitute one of the serious problems among combat sports practitioners in japan. to facilitate the diagnosis of individuals at risk, we undertook a study to determine which body sites are most commonly infected. we reviewed medical data, hairbrush culture results and questionnaire information from patients with t. tonsurans infection who were admitted to the dermatology clinic of juntendo university hospital from 2000 to 2004. the study included 92 ...200818793263
epidemiologic and clinicomycologic profile of onychomycosis from north india.onychomycosis is an important public health problem because of the increase in immunosuppressive states. large-scale studies in india are scarce, and so the baseline incidence of onychomycosis is not firmly established.200818477149
susceptibility of dermatophyte isolates obtained from a large worldwide terbinafine tinea capitis clinical trial.our group, in collaboration with seven other laboratories, has recently developed a method to determine the susceptibility of dermatophytes.200818510668
asymptomatic dermatophyte scalp carriage: laboratory diagnosis, epidemiology and management.asymptomatic carrier is defined as an individual who has dermatophyte-positive scalp culture without signs or symptoms of tinea capitis. the prevalence of asymptomatic carriage differs from region to region with a rate of 0.1-49%. anthropophilic dermatophytes, trichophyton tonsurans and trichophyton violaceum, have been generally associated with high rates of asymptomatic carriage. hence, the presence of dermatophytes on healthy scalp hairs of children may be a potential source of infection for ...200818034369
comparison of hairbrush, toothbrush and cotton swab methods for diagnosing asymptomatic dermatophyte scalp carriage.tinea capitis may also present as a minimal infection, termed carrier state. anthropophilic dermatophytes (i.e. trichophyton tonsurans and trichophyton violaceum) have been generally associated with high rates of asymptomatic carriage.200818269603
management and follow-up survey of trichophyton tonsurans infection in a university judo club.the prevalence of trichophyton tonsurans infection of the scalp in members of a university judo club (combat sport) was investigated over a 3.5-year period using a questionnaire survey and an assay based on fungal culture by the hairbrush method. in november 2002, 11 (35%) of 31 athletes were found to be positive for t. tonsurans infection by the hairbrush method and provided treatment with oral and topical antifungal agents according to a prescribed protocol. all the infected subjects became cu ...200818399905
outbreak of tinea gladiatorum in wrestlers in tehran (iran).in recent years, skin diseases in wrestling have finally received the attention they deserve. outbreaks of tinea corporis are often associated with sports involving extensive bodily contact; such sports include wrestling. tinea corporis gladiatorum is primarily caused by trichophyton tonsurans, infecting wrestlers at alarming rates. the management of skin infections in wrestlers and other athletes in sports involving skin-to-skin contact entails numerous challenges, from making an accurate diagn ...200819882012
in vitro activity of penicillium chrysogenum antifungal protein (paf) and its combination with fluconazole against different dermatophytes.strains of five dermatophyte species (microsporum canis, microsporum gypseum, trichophyton mentagrophytes, trichophyton rubrum and trichophyton tonsurans) were selected for testing against penicillium chrysogenum antifungal protein (paf) and its combination with fluconazole (fcz). inhibition of microconidia germination and growth was detected with mics of paf ranging from 1.56 to 200 microg ml(-1) when it was used alone, or at constant concentration (100 microg ml(-1)) in combination with fcz at ...200818574706
[screening examination of trichophyton tonsurans among judo practitioners at the all japan inter high school championships, saga 2007].this paper presents the results of an examination for trichophyton tonsurans(t. tonsurans)performed by the hairbrush (hb; 90 bristles)method at the all japan inter high school championships, saga 2007. samples were taken from 487 judo practitioners (265 males and 222 females) out of a total of 951. the areas with the highest positive rates were: kyushu 21%(15 participants out of 73 sampled), tohoku 17% (13 out of 77), kinki 16% (14 out of 89), and chubu 13% (12 out of 89). four participants from ...200819001758
changes in frequency of agents of tinea capitis in school children from western china suggest slow migration rates in dermatophytes.tinea capitis is a common dermatophyte infection of the scalp of children in western china, with the gray-patch from being the most prevalent. twenty years ago, the most widespread etiologic agent was reported to be trichophyton violaceum, which was later succeeded by microsporum ferrugineum and trichophyton schoenleinii. in the framework of our recent study, 97 isolates were collected from patients with clinically suspected tinea capitis. identification was performed by conventional methods and ...200818608883
efficacy of local herbal therapy in the management of dermatophytosis among primary school children in cross river state, south-south nigeria.as a contribution to the on-going search for alternative, available and affordable treatment of common infections in sub-saharan africa, the efficacy of local herbs, senna alata(linn) and borreria ocymoides (burm), in comparison with conventional drugs, griseofulvin and clotrimazole in the treatment of dermatophytosis among primary school children, was examined in the three districts of cross river state, south-south nigeria. out of 840 pupils screened, 68 (8.1%) were infected, with incidence ra ...200920175416
prevalence of tinea pedis, tinea unguium of toenails and tinea capitis in school children from barcelona.to evaluate the prevalence of tinea capitis, tinea pedis, and tinea unguium in children from several schools of barcelona city.200919766517
epidemiological survey of dermatophytosis in tehran, iran, from 2000 to 2005.cutaneous fungal infections are common in tehran, iran, and causative organisms include dermatophytes, yeasts and non-dermatophyte molds. the prevalence of superficial mycosis infections has risen to such a level that skin mycoses now affect more than 20-25% of the world's population, making them the most frequent form of infection.200919293500
[summarization of tinea capitis cases encountered at a clinic in the past 5 years].twelve cases of tinea capitis were encountered at a clinic in kumamoto prefecture between april 2004 and december 2008. patients were boys aged between 2 and 18 in 11 cases, and a woman aged 50 years in 1 case. the pathogen was microsporum canis in 6 cases, and trichophyton tonsurans in 6 cases. in the cases with m. canis , patients were boys aged 2 to 8 years in 5 cases, and the type of disease was non-inflammatory in 5 cases and inflammatory in 1 case. the patients with t. tonsurans were boys ...200919654449
screening examination and treatment of trichophyton tonsurans infection in judo athletes affiliated with the university judo federation of tokyo.summary in japan, trichophyton tonsurans infection has become an increasing problem among combat sports participants. we investigated the prevalence of t. tonsurans infection in athletes affiliated to judo clubs in the 21 first division universities that were registered with the university judo federation of tokyo in 2008. study procedures performed by the subjects included (i) completion of a questionnaire concerning lifestyle, risk factors for tinea corporis and medical history; (ii) scrubbing ...200920002880
griseofulvin only modestly diminishes persistence of trichophyton tonsurans on the scalp of carriers.using genetic strain typing, we previously identified a high rate of t. tonsurans carriage among preschool-aged children attending an urban daycare center. no treatment was provided as part of the observational study; however, children when symptomatic were treated in accordance with daycare policies. this retrospective investigation examines antifungal drug therapy received during the previous investigation and characterizes the impact of treatment on persistence of the fungus on the scalp.200923055896
a large outbreak of trichophyton tonsurans among health care workers in a pediatric hospital.although trichophyton tonsurans remains a major cause of dermataophytoses in us children, nosocomial spread may go unrecognized in health care settings. we describe a staff outbreak of t tonsurans infection among health care workers in a freestanding pediatric hospital.200918834726
dermatophyte infections in cairo, egypt.in this study, we examined dermatophyte infections in patients referred to the department of dermatology, el-houd el-marsoud hospital, cairo, during march 2004 to june 2005. of 506 patients enrolled in this investigation, 403 (79.6%) were clinically diagnosed as having dermatophytoses (age range 6-70 years; males 240; females 163). species identification determined by observation of their macroscopic and microscopic characteristics was complemented with sequencing of the internal transcribed spa ...200918972221
fungistatic effects of optical brightener 220 against trichophyton tonsurans, aspergillus fumigatus and candida albicans.dermatophytes are one of the main causes of dermal infections. moreover, there are some opportunistic fungi such as aspergillus fumigatus (mycelial form) and candida albicans (yeasty form) that in immunosuppressed patients can cause cutaneous disease.200919003591
trichophyton species susceptibility to green and red propolis from brazil.the in vitro antifungal activity of brazilian green and red propolis was tested against different species of trichophyton.200919018958
in vitro pharmacodynamic characteristics of griseofulvin against dermatophyte isolates of trichophyton tonsurans from tinea capitis patients.tinea capitis is the most commonly observed fungal infection in childhood and is primarily caused by the dermatophyte species trichophyton tonsurans, microsporum canis, and trichophyton violaceum. in north america and the united kingdom t. tonsurans is responsible for more than 90% of cases. griseofulvin has been the treatment of choice for tinea capitis for more than 40 years and is the sole oral antifungal agent approved by the fda for the management of tinea capitis. some researchers have exp ...200919212895
genotyping of trichophyton tonsurans isolate from a japanese boy reveals infection in the usa. 200919236416
changing face of tinea capitis in europe.the aim of this review is to update the latest epidemiological situation in europe, explore recent issues in recognition and emerging opportunities in diagnosis and look at progressions in treatment. papers reviewed have, in the main, been published within the last 2 years.200919262376
clinico-etiologic correlates of onychomycosis in sikkim.the etiological spectrum of any superficial mycosis is largely dependent on the flora in the immediate environment of the individual. it is influenced by the geographic, climatic and occupational factors. the study is basically to formulate baseline data for the species prevalence of various dermatophytes in patients with onychomycosis attending the central referral hospital, gangtok, sikkim.200919332910
epidemiology of fungal scalp infections in the west of scotland 2000-2006.fungal infections of the scalp commonly affect the paediatric population and are caused by dermatophytes which have the ability to invade the keratinised structures of skin, hair and nails. this study analyses the changes in the epidemiology of fungal scalp infections in the west of scotland during the period 2000-2006.200919530495
tinea capitis mimicking tufted hair folliculitis.we report a case of tinea capitis mimicking tufted hair folliculitis in a 56-year-old european man, who presented with a 4-year history of pain and erythema in an area of scarring alopecia of the occipital scalp, with scales and tufts of hair emerging from individual follicles. histological examination showed hair plugging, and a dense perifollicular infiltrate of plasma cells, lymphocytes, and neutrophils. there was widespread scarring and fibrosis. bacterial cultures were negative for staphylo ...200919663859
trichophyton tonsurans-ringworm in an nicu.ringworm is very rarely found in the neonate, especially infants who have been confined from birth to an intensive care unit. we report an infection with the dermatophyte trichophyton tonsurans, the most common cause of tinea capitis in children but not yet described in a premature baby who has never left the nursery. our case illustrates the need to consider this diagnosis among the causes of dermatitis in the newborn, especially in at-risk populations such as indigenous australians. though our ...200919720594
the emergence of trichophyton tonsurans in port-au-prince, haiti.the occurrence of the anthropophilic dermatophyte trichophyton tonsurans as a frequent causative agent of tinea capitis in several developed countries has been associated with a global rise in its isolation during recent years. while t. tonsurans was never found in haiti before 1988, a sharp increase in the number of isolates of this species from scalp lesions began to be observed in 2005 in port-au-prince, haiti. a prospective study was conducted in port-au-prince from may to november 2006 of 6 ...200918608887
[epidemiological correlation between keratinophilic fungi isolated from soil and dermatomycosis agents].this study had the aim of isolating and identifying keratinophilic fungi from soil and correlating them with dermatomycosis agents. according to our results, the predominance of trichophyton tonsurans as a dermatomycosis agent among children in the city of recife, pe, is probably due to children's greater contact with soil.200919802490
tinea capitis in southwest poland.tinea capitis in southwest poland is mainly caused by zoophilic dermatophytes. microsporum canis is the main pathogen, which was demonstrated in all analysed periods between 1977 and 2006 (50.5%-63.2%). recently (2002-2006), a significant (p < 0.05) increase of trichophyton tonsurans isolates was observed, which may be due to increasing migration of polish population in this period. to sum up, the data on the prevalence of tinea capitis in southwest poland resemble the epidemiological situation ...200918793266
recovery of dermatophytes in pet grooming tools from veterinary clinics and pet grooming salons.fomites such as brushes and clippers are known to be potential risk factors for the transmission of dermatophytes between pet animals. the aim of this study was to investigate this risk by examining those grooming implements for the presence of any viable dermatophytes.201020137008
[emergence of microsporum audouinii and trichophyton tonsurans as causative organisms of tinea capitis in the dominican republic].tinea capitis affects mainly children. the frequency and causative organism vary from region to region.201020487688
clonal outbreak of trichophyton tonsurans tinea capitis gladiatorum among wrestlers in adana, turkey.tinea capitis gladiatorum and tinea corporis gladiatorum caused by the anthropophilic dermatophyte trichophyton tonsurans are well-known clinical entities in individuals involved in combat sports, e.g., wrestlers and judo practitioners. we present an outbreak of trichophyton tonsurans tinea capitis gladiatorum among wrestlers at a boarding school in adana, turkey. fourteen of the 29 wrestlers examined (48.3%) harbored the pathogen, including eight asymptomatic scalp carriers, five with tinea cap ...201019824879
tinea capitis among children in the columbus area, ohio, usa.tinea capitis is a fungal infection of the hair follicles of the scalp. in the us, the most common organisms have traditionally been trichophyton tonsurans, and occasionally microsporum canis. this study was designed to examine patterns of organisms causing tinea capitis and determine factors associated with infection. a retrospective database analysis was conducted to locate records of patients with tinea capitis from may 2001 to may 2006 at nationwide children's hospital in columbus, oh. descr ...201019302461
divergence among an international population of trichophyton tonsurans isolates.trichophyton tonsurans is a widely distributed pathogen that demonstrates a significant degree of genetic and phenetic heterogeneity. to date, the degree of genetic relatedness among geographically segregated isolates has not been explored. this investigation evaluates the extent of genetic variation among an international population of t. tonsurans isolates and examines the relatedness of isolates within and between countries. molecular strain typing was performed on 198 isolates obtained from ...201019609717
in vitro antifungal activity of indirubin isolated from a south indian ethnomedicinal plant wrightia tinctoria r. br.acalypha indica, cassia alata, lawsonia inermis, punica granatum, thespesia populnea and wrightia tinctoria are folklore medicines extensively used in the treatment of ringworm infections and skin related diseases in tamil nadu, india.201020691774
[dermatophytoses due to anthropophilic fungi in cadiz, spain, between 1997 and 2008].cutaneous fungal infections are a major public health problem. the distribution of the dermatophytoses varies between countries and geographical areas. the aim of this study was to determine the incidence, epidemiology, etiology, and clinical course of the dermatophytoses caused by anthropophilic fungi in cadiz, spain, over the past 12 years.201020398600
[role of cytokine secretion of human keratinocytes in dermatophytosis].the clinical presentation of dermatophytosis depends on species of the infecting fungus. the infections caused by the anthropophilic species tend to be chronic and intractable, and the resultant inflammation is minimal. on the other hand, the infections caused by the geophilic and zoophilic species tend to be self-healing, and the resultant inflammation is more severe. we investigated the role of cytokine secretion of human keratinocyte during dermatophyte infections: arthroderma benhamiae, a zo ...201020716850
chronically recurrent and disseminated tinea faciei/corporis--autoinoculation from asymptomatic tinea capitis carriage.we report clinical findings in a 12-year-old girl with long-term recurrent and disseminated multiple eruptions of tinea faciei and tinea corporis, which persisted for 10 years. mycological examination revealed the dermatophyte trichophyton tonsurans in both scale samples from the body lesions and in brushing samples from her asymptomatic scalp, suggesting that she was an asymptomatic dermatophyte carrier on the scalp, and autoinoculation of the dermatophyte was responsible for the recurrent and ...201020796239
comparative analysis of secreted enzymes between the anthropophilic-zoophilic sister species trichophyton tonsurans and trichophyton equinum.trichophyton tonsurans (tt) and trichophyton equinum (te) are two closely related dermatophytes with very different host preferences. this study was designed to examine the genetic and transcript level variations of secreted enzymes between tt and te. thirty-one genes representing 10 gene families were selected for comparison and complete genomic and cdna sequences were elucidated. sequence analyses of the selected genes identified 104 polymorphisms between the two dermatophytes, 37 of which are ...201020943153
the prevalence of infections with trichophyton tonsurans in schoolchildren: the capitis study.although trichophyton tonsurans has become the leading cause of tinea capitis in the united states, reported infection rates vary widely, and prevalence estimates for the pediatric population at large remain poorly characterized.201020403937
onychomycosis observed in children over a 20-year period.summary there are few reports studying the aetiology of onychomycosis in children in spain. to study childhood dermatophyte onychomycosis, a retrospective study of children was carried out, who were <16 years of age with dermatophyte onychomycosis diagnosed between 1987 and 2007. of 4622 nail samples from 3550 patients, 218 came from 181 children up to 16 years old. onychomycosis caused by dermatophytes was demonstrated in 28 (15.5%) cases. trichophyton rubrum (18 cases) was the most prevalent s ...201020406389
tinea capitis in birmingham: survey of elementary school students.trichophyton tonsurans is currently the leading cause of tinea capitis, but was only introduced into the united states less than six decades ago. in this study, we found a prevalence of 11% in birmingham, alabama, which is similar to earlier reports from other geographic regions. despite previous reports concerning escalation, the prevalence appears to be stable over the past decade.201020553397
organization and evolutionary trajectory of the mating type (mat) locus in dermatophyte and dimorphic fungal pathogens.sexual reproduction in fungi is governed by a specialized genomic region, the mating type (mat) locus, whose gene identity, organization, and complexity are diverse. we identified the mat locus of five dermatophyte fungal pathogens (microsporum gypseum, microsporum canis, trichophyton equinum, trichophyton rubrum, and trichophyton tonsurans) and a dimorphic fungus, paracoccidioides brasiliensis, and performed phylogenetic analyses. the identified mat locus idiomorphs of m. gypseum control cell t ...201019880755
evaluation of the association of superficial dermatophytosis and athletic activities with special reference to its prevention and control.this study was conducted to evaluate the association of superficial mycosis and athletic activities with special references to its prevention and control in tehran. participating in various kinds of sports can lead to direct and indirect exposures to and transmission of micro-organisms between athletes and also passive observers.201020636349
prevalence and causative fungal species of tinea capitis among schoolchildren in gabon.summary tinea capitis is endemic among schoolchildren in tropical africa. the objective was to determine the prevalence of symptomatic tinea capitis in schoolchildren in gabon. a cross-sectional study was conducted with 454 children aged 4-17 years, attending a rural school and an urban school. the diagnosis of tinea capitis was based on clinically manifest infection, direct microscopic examination using 20% potassium hydroxide (koh) solution and fungal culture. based on clinical examination, 10 ...201020637052
Molecular Epidemiology of Trichophyton tonsurans Strains Isolated in Japan between 2006 and 2010 and Their Susceptibility to Oral Antimycotics.Trichophyton tonsurans has been isolated among judo practitioners, wrestlers, and sumo wrestlers during an epidemic of tinea corporis and tinea capitis in Japan. A previous study using restriction fragment length polymorphism (RFLP) analysis of the non-transcribed spacer (NTS) region of the ribosomal RNA gene revealed that different sources for the causative fungus in epidemics among judo practitioners and among wrestlers. Many different fungal strains have since been isolated from practiti ...201122116323
a clinico-epidemiological study on tinea gladiatorum in iranian wrestlers and mat contamination by dermatophytes.dermatophytosis is still being considered as one of the major public health problems in wrestlers. objectives: to identify the prevalence, clinical pattern, aetiological agents and the predominant transmission route of dermatophytoses in iranian wrestlers, a study was carried out in 2008. in total, 270 wrestlers from eight wrestling salons were evaluated. classical mycological techniques were performed on 135 skin scraping samples of 110 wrestlers suspicious for dermatophytoses and 240 touch pre ...201119917034
trichophyton tonsurans in a family microepidemic.trichophyton tonsurans is a highly transmissible anthropophilic dermatophyte fungus, which invades keratinized tissues. this study reports a case of family microepidemic caused by this dermato phyte. despite their excellent hygiene conditions, it remained active for several years, spreading to all family members. the hypothesis that the fungus was being kept alive in the family home was confirmed after samples collected from it were analyzed. pure cultures of the fungus were isolated and identif ...201122147044
tinea capitis and tinea corporis with a severe inflammatory response due to trichophyton tonsurans.trichophyton tonsurans is an anthropophilic dermato-phyte, with a worldwide distribution, although its prevalence varies considerably between different geographical regions. whereas in north america infections due to this fungus are exceptionally common, on the european continent they appear relatively seldom. although t. tonsurans is primarily associated with tinea capitis, it can also be the cause of tinea corporis and tinea unguium. the course of infection is usually only mildly symptomatic. ...201121710105
tinea capitis in elderly women: a report of 4 cases.tinea capitis is a condition usually found only in children. however, its epidemiological profile has changed in recent decades, with regard to age at onset and the causative microorganisms. we report the cases of 4 women over 65 years of age diagnosed with tinea capitis. one presented plaques of alopecia with desquamation and the other 3 developed crusted inflammatory lesions. cultures were positive for trichophyton tonsurans (2 patients), trichophyton rubrum, and trichophyton mentagrophytes. t ...201121592449
carbohydrate profiling of fungal cell wall surface glycoconjugates of trichophyton tonsurans and other keratinophilic filamentous fungi using lectins.various researchers have concluded that lectins are useful reagents for the study of fungal cell wall surface glycoconjugates. in this study, we evaluated the expression of n-acetyl-d-glucosamine, l-fucose, d-galactose and glucose/mannose on the cell wall surface of trichophyton tonsurans and other keratinophilic filamentous fungi, using a simple lectin-binding protocol. the fungal cultures used were isolated from soils obtained from public parks by the hair-bait technique. the lectin assays use ...201121615541
ganoderma lucidum: a source for novel bioactive lectin.ganoderma lucidum is known for its high medicinal value, clinically used in treatment for various diseases. we have selected this mushroom for isolation of novel bioactive lectin. the isolation procedure comprised of ion-exchange chromatography on deae- cellulose and affinity chromatography on affi-gel blue gel. purified lectin was monomer with a molecular mass of 15 kda, determined by sds-page, gel filtration, maldi-tof. it showed hemagglutinating activity against both human and animal erythroc ...201121728991
prevalence of tinea capitis in southeastern austria between 1985 and 2008: up-to-date picture of the current situation.tinea capitis is the most common dermatophyte infection in childhood, but may rarely occur in adults and the elderly. causative agents vary within different geographical areas as well as during decades. the aim of this study was to evaluate the prevalence and causative agents of tinea capitis in southeastern austria. retrospective analysis of 714 patients diagnosed with tinea capitis seen at the outpatient department of dermatology/medical university of graz during the time period 1985-2008 was ...201119863725
trichophyton tonsurans scalp carriage among wrestlers in a national competition in turkey.trichophyton tonsurans tinea gladiatorum is an emerging epidemic among combat-sport athletes across the globe. in the present study, we investigated the prevalence of symptomatic and asymptomatic dermatophytic infections among wrestlers in the national greco-roman championship in turkey. in total, 194 wrestlers from 32 provinces and 72 clubs were examined for scalp, trunk, groin, and toe web dermatophytic infections. we also administered a questionnaire to obtain information on the participants' ...201121472391
antidermatophytic activity of pyrazolo[3,4-c]isothiazoles: a preliminary approach on 4-chlorophenyl derivative for evaluation of mutagenic and clastogenic effects on bacteria and human chromosomes in vitro.the antifungal activity of eight pyrazolo[3,4-c]isothiazole derivatives was evaluated on five dermatophytes: three were of an anthropophilic species (i.e., epidermophyton floccosum, trichophyton rubrum, and trichophyton tonsurans) and two were of a geophilic species (i.e., microsporum gypseum and nannizzia cajetani). the new compounds proved to be unlikely effective in inhibiting the growth of the different strains. in general, the fungi parasitic on man were more sensitive than the geophilic sp ...201121649488
epidemiology of superficial fungal diseases in french guiana: a three-year retrospective analysis.a three-year retrospective analysis of fungi isolated from specimens of patients with superficial fungal infections in french guiana is presented. clinical samples from 726 patients with presumptive diagnoses of onychomycosis (28.2% of the patients), tinea capitis (27.8%), superficial cutaneous mycoses of the feet (22.0%), and of other areas of the body (21.9%), were assessed by microscopic examination and culture. dermatophytes accounted for 59.2% of the isolates, followed by yeasts (27.5%) and ...201121314249
inhibition of growth of trichophyton tonsurans by lactobacillus reuteri.aim:  the aims of this study were to identify antifungal lactic acid bacteria (lab) and characterize their activity against the dermatophyte trichophyton tonsurans. methods and results:  a total of 165 different lab were isolated and initially screened for anti-penicillium expansum activity. five strains, which exhibited strong inhibitory activity, were then tested against the dermatophyte t. tonsurans dsm12285, where they also caused inhibition as observed by large fungal clearing on agar surfa ...201121645181
A retrospective study of the management of pediatric kerion in Trichophyton tonsurans infection.Kerion celsi is the inflammatory extreme of tinea capitis, representing a delayed hypersensitivity reaction to the causative dermatophyte. Some authors have advocated the use of oral corticosteroids in patients with kerion formation to inhibit the host inflammatory response and minimize the risk of scarring. This retrospective study analyzed the management and outcome of all children younger than 10 years old presenting to our pediatric dermatology service with tinea capitis resulting in kerion ...201122082462
Extra-Scalp Black Dot Ringworm Caused by Trichophyton tonsurans Among Contact Sports Players.We describe here two patients with tinea corporis exhibiting black dot ringworm (BDR). A cluster of black dots was observed on the extensor surfaces of the extremities of two rather hairy male patients, a 15-year-old judo practitioner and a 26-year-old combined martial arts fighter, during treatment of tinea corporis with topical antimycotics. Direct KOH examination showed that the black dots were composed of degenerated hair with numerous arthroconidia and were indistinguishable from BDR of tin ...201122071663
a 5-year survey of dermatomycoses in southwest poland, years 2003-2007.the study was performed to analyse the spectrum of dermatomycoses in southwest poland during the period 2003-2007. a total of 10,486 patients were investigated for fungal skin infections by means of native specimen and cultivating procedures. skin scrapings, plucked hairs and nail clippings were examined and identified by direct microscopy and culture. from 2468 patients, 2753 fungi were identified including dermatophytes, yeast and moulds. among the dermatophytes, the most common pathogen isola ...201119925570
tinea corporis gladiatorum presenting as a majocchi granuloma.background. wrestlers are at increased risk of developing cutaneous infections, including fungal infections caused by dermatophytes. erythematous lesions due to tinea infections can be mistakenly diagnosed as an inflammatory dermatitis and incorrectly treated with potent topical corticosteroid treatments which cause localized skin immunosuppression. this can eventuate in a majocchi granuloma which then becomes refractory to topical antifungal therapy. to our knowledge, this is the first case of ...201122363858
inflammatory tinea capitis due to trichophyton tonsurans in a high school wrestler. 201121605194
increasing place of trichophyton tonsurans in paris, france: a 15-year retrospective study. 201122059675
tinea faciei in a newborn due to trichophyton tonsurans.we report here the first case of neonatal tinea faciei caused by trichophyton tonsurans in mainland china. the mother of the infant had tinea corpris and tinea capitis while the father had tinea incongnito. the infections in the parents were mycologically confirmed to be due to trichophyton tonsurans. ttinea faciei in the infant was cured after two-week topical use of amorolfine cream. the mother ceased breastfeeding and took oral terbinafine for 4 weeks. no recurrence was observed in the infant ...201223554797
discovery and characterization of a group of fungal polycyclic polyketide prenyltransferases.the prenyltransferase (ptase) gene vrtc was proposed to be involved in viridicatumtoxin (1) biosynthesis in penicillium aethiopicum. targeted gene deletion and reconstitution of recombinant vrtc activity in vitro established that vrtc is a geranyl transferase that catalyzes a regiospecific friedel-crafts alkylation of the naphthacenedione carboxamide intermediate 2 at carbon 6 with geranyl diphosphate. vrtc can function in the absence of divalent ions and can utilize similar naphthacenedione sub ...201222590971
tinea capitis in the form of concentric rings in an hiv positive adult on antiretroviral treatment.dermatophyte infection may present in the form of concentric rings caused by trichophyton concentricum, known as tinea imbricata. in immunosuppressed patients, there are reports of lesions in the form of concentric rings caused by dermatophytes other than trichophyton concentricum too, mostly by trichophyton tonsurans, known as tinea indesiciva or tinea pseudoimbricata. we report a case of tinea capitis in a hiv-positive adult woman on antiretroviral therapy, who presented with concentric rings ...201222837564
frequency and aetiology of dermatophytosis in children age 12 and under in the state of amazonas, brazil.few scientific studies have evaluated dermatophytosis among children in the state of amazonas or in the greater northern region of brazil.201222410497
dermatophytes isolated from the mosques in tokat, turkey.dermatophytes are a group of fungi that invade keratinized tissues such as the skin, hair and nails. the aim of this study was to investigate the existence of the potential causative agents of dermatophytosis in the mosque area in tokat, turkey. thirty mosques were included in the study. a total of two hundred samples were collected from various parts of carpets and slippers in the mosques. positive cultures were obtained in 144 samples (113 from carpets, 31 from slippers). among the species iso ...201222576940
epidemiology of dermatophytoses in crete, greece between 2004 and 2010.the present work was undertaken in order to study the epidemiology of dermatophytoses in the island of crete, greece, over a 7-year period (2004-2010) and to compare the results with those reported earlier from this region and from other parts of the world.201222648332
comparative genome analysis of trichophyton rubrum and related dermatophytes reveals candidate genes involved in infection.the major cause of athlete's foot is trichophyton rubrum, a dermatophyte or fungal pathogen of human skin. to facilitate molecular analyses of the dermatophytes, we sequenced t. rubrum and four related species, trichophyton tonsurans, trichophyton equinum, microsporum canis, and microsporum gypseum. these species differ in host range, mating, and disease progression. the dermatophyte genomes are highly colinear yet contain gene family expansions not found in other human-associated fungi. dermato ...201222951933
treatment outcomes for tinea capitis in a skin of color population.tinea capitis periodically undergoes demographic shifts in causative dermatophyte and therapeutic response to oral anti-fungal therapy.201222777228
discrimination of trichophyton tonsurans and trichophyton equinum by pcr-rflp and by β-tubulin and translation elongation factor 1-α sequencing.trichophyton tonsurans and t. equinum are two closely related sister species of dermatophytes, but differ in their preferred hosts, i.e., humans or horses, respectively. routine procedures for their identification depend on studies of their phenotypic, physiological and biochemical characteristics, which are laborious and may yield ambiguous results. molecular methods using rdna its also had been judged to be insufficiently discriminatory. in the present study two genetic markers were sequenced ...201222369622
prevalence of fungal skin infections in iranian wrestlers.fungal infections are one of the most common skin infections. athletes, especially in contact sports such as wrestlers are the group at risk of fungal skin infections (fsi). the aim of this study was to determine prevalence of fsi and some effective factors in wrestlers in tehran, iran.201223785573
semisynthesis and antimicrobial activity of novel guttiferone-a derivatives.six derivatives of guttiferone-a (lfqm-79, 80, 81, 82, 113 and 114) were synthesized and evaluated for their antimicrobial activity against the opportunistic or pathogenic fungi candida albicans (atcc 09548), candida glabrata (atcc 90030), candida krusei (atcc 6258), candida parapsilosis (atcc 69548), candida tropicalis (atcc 750), cryptococcus neoformans (atcc 90012), trichophyton tonsurans, microsporum gypseum and also against the opportunistic and pathogenic gram-positive bacteria staphylococ ...201222401914
the results of trichophyton tonsurans screening examinations and infection management in university judo federation of tokyo athletes over a 4-year period.t. tonsurans infection is spreading among combat sport athletes in japan, and preventive measures are necessary.201223257728
[the present state of trichophyton tonsurans infection in japan and measures to combat it].more than 10 years have passed since trichophyton tonsurans infection first began to increase in japan. initially the infection was confined to high school and university students participating in combat sports clubs, but it has now spread among the athletes' family members and friends. in a recent survey, 10% of judo athletes tested positive for trichophyton tonsurans; most were asymptomatic carriers. t.tonsurans infection usually causes tinea corporis or tinea capitis, but lesions can occur on ...201223149352
genetic predictors of susceptibility to cutaneous fungal infections: a pilot genome wide association study to refine a candidate gene search.trichophyton tonsurans is the foremost fungal pathogen of minority children in the u.s. despite overwhelming infection rates, it does not appear that this fungus infects children in a non-specific manner.201222704677
tinea capitis in botswana.tinea capitis (tc) is a common dermatophyte infection of the scalp that can also involve the eyebrows and eyelashes.201323386791
prevalence and risk factors of onychomycosis in primary school children living in rural and urban areas in central anatolia of turkey.onychomycosis is a world-wide public health concern in children, requiring epidemiological data for different regions for control and prevention.201324177609
trichophyton tonsurans induced recurrent onychomadesis in a very young infant.onychomadesis, or nail shedding, is rarely seen in children and can be due to stress, systemic illnesses, trauma, and drug therapy or may be idiopathic. fungal infection of the nail is only rarely reported as a cause of onychomadesis. we present here a case of trichophyton tonsurans-induced onychomycosis and resultant onychomadesis in a 9-month-old boy with onset of lesions at 2 weeks of life.201322299755
trichophyton tonsurans strains from brazil: phenotypic heterogeneity, genetic homology, and detection of virulence genes.the objective of this study was to establish the phenotypical and molecular patterns of clinical isolates of trichophyton tonsurans circulating in the state of ceará, northeastern brazil. for this purpose, 25 t. tonsurans strains isolated from independent cases of tinea capitis in children were phenotypically evaluated regarding their macro- and micro-morphological characteristics, vitamin requirements, urease production, and antifungal susceptibility. the molecular characterization was carried ...201324206358
epidemiologic trends in pediatric tinea capitis: a population-based study from kaiser permanente northern california.epidemic levels of tinea capitis (tc) have previously been reported in children.201324094452
inflammatory tinea capitis mimicking dissecting cellulitis in a postpubertal male: a case report and review of the literature.tinea capitis in postpubertal patients is unusual and may be misdiagnosed as dissecting cellulitis. we report a case of a healthy 19-year-old hispanic male presenting with a 2-month history of a large, painful subcutaneous boggy plaque on the scalp with patchy alopecia, erythematous papules, cysts and pustules. although initially diagnosed as dissecting cellulitis, potassium hydroxide evaluation (koh preparation) of the hair from the affected region was positive. a punch biopsy of the scalp demo ...201323582018
microsatellite-primed pcr and random primer amplification polymorphic dna for the identification and epidemiology of dermatophytes.this study demonstrates the capacity of the one-step polymerase chain reaction (pcr) fingerprinting method using the microsatellite primers (gaca)4 or (gtg)5 (msp-pcr) to identify six of the most frequent dermatophyte species causing cutaneous mycosis. pcr with (gaca)4 was a suitable method to recognise microsporum canis, microsporum gypseum, trichophyton rubrum and trichophyton interdigitale among 82 argentinian clinical isolates, producing the most simple and reproducible band profiles. in con ...201323412735
simple identification of trichophyton tonsurans by chlamydospore-like structures produced in culture media.trichophyton tonsurans is known to be the causative agent of a worldwide epidemic of dermatophytoses among contact sports practitioners, and is spreading among the general population of japan. prompt and simple identification of t. tonsurans in diagnostic laboratories is crucial to control infection. the present study evaluated the availability of observation of chlamydospore-like structures grown in culture media as a characteristic for identification of t. tonsurans. twenty-five strains of t.  ...201324304336
tinea corporis due to trichophyton mentagrophytes and trichophyton tonsurans mimicking tinea imbricata. 201323760341
epidemiology of dermatophytosis in junior combat and non-combat sports participants.participation in competitive sports is popular and widely encouraged worldwide. herein, we investigated 252 male and 67 female sports players, aged 16.4 ± 1.3 years, active in 15 different types of combat (n = 143) and non-combat (n = 176) sports. of the 319 participants in this study, 11 (3.5%) players, including six wrestlers, four football players and one handball player, all of whom were men, harboured dermatophytic fungi. briefly, trichophyton tonsurans was present in three athletes, who we ...201322621172
in vitro antifungal activity of micafungin and caspofungin against dermatophytes isolated from china.the aims of this study are to investigate the in vitro activities of micafungin and caspofungin that are two new echinocandin antifungal drugs against clinically isolated dermatophytes in china and to define mec (minimal effective concentration) as the reading endpoints of this study in accordance with (clinical and laboratory standards institute) clsi m38-a2 reference.201322983900
public health significance of dermatophytes in ismailia and port said provinces, egypt.[corrected] dermatophytes are common in both developed and developing countries, the species involved and the resulting clinical entities vary geographically.201323760076
in vitro activities of antifungal drugs against dermatophytes isolated in tokat, turkey.in this study, we aimed to establish the in vitro antifungal susceptibilities of terbinafine, miconazole, itraconazole, ketoconazole, griseofulvin, and amphotericin b against dermatophyte isolates.201324134487
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