Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| intracellular viral rna species in mouse cells nonproductively transformed by the murine sarcoma virus. | the size and quantity of virus-specific rna in five non-virus-producing mouse cells transformed by the moloney isolate of murine sarcoma virus (msv) was determined. hybridization of rna from transformed cells with the [(3)h]dna product of the rna-directed dna polymerase of the murine sarcoma-leukemia virus was used to detect and quantitate virus-specific rna. the amount of virus-specific rna in non-virus-producing cells was less than one-sixth of that found in virus-producing cells. a striking c ... | 1974 | 4852536 |
| isolation and characterization of "8s" rna in murine sarcoma virus-infected cells. | 1974 | 4473984 | |
| revertants of mouse cells transformed by murine sarcoma virus. iii. metastable expression of virus functions in revertants retransformed by murine sarcoma virus. | 3t3fl cells transformed by the moloney murine sarcoma virus (msv) (sarcoma positive, leukemia negative, s+l- cells) segregate spontaneous flat revertants. these s-l- revertants do not release msv upon superinfection with mulv but are susceptible to a second cycle of single-hit msv transformation. the behavior and nature of second-cycle msv transformed revertants were followed by successive clonal generations. the second transformation by msv resulted in a number of metastable states. the simples ... | 1974 | 18620232 |
| the growth of transplanted tumours in mice after chronic inhalation of fresh cigarette smoke. | the subcutaneous growth of the lewis lung tumour in c57bl mice chronically exposed to fresh cigarette smoke was increased above that in age-matched control mice. when murine sarcoma virus (harvey) induced tumour cells were introduced to the lungs of groups of balb/c mice, only mice chronically exposed to fresh cigarette smoke died with tumour cells in the lungs. tumour cell growth in mice during short term cigarette smoke exposure was indistinguishable from that in controls. | 1974 | 4377708 |
| effect of vitamin a on tumor development in burned, unburned, and glucocorticoid-treated mice inoculated with an oncogenic virus. | high doses of vitamin a decreased the severity of tumor development in mice inoculated with a murine sarcoma virus; the same doses of vitamin a had no effect on the increased tumorigenesis seen in animals severely stressed with thermal injury or the increased tumorigenesis induced by exogenous glucocorticoid administration. | 1975 | 173574 |
| murine sarcoma virus defectiveness. viral polymerase expression in murine and nonmurine host cells transformed by s + l - type murine sarcoma virus. | sarcoma virus-positive, leukemia virus-negative (s + l -) mouse cells transformed by defective but rescuable murine sarcoma virus (msv) release noninfectious type c virions with a quantitative deficiency of viral-type rna-dependent dna polymerase (rddp). human s + l - cells containing the same genome fail to express any detectable viral-type reverse transcriptase. to study this difference in msv expression, second-generation msv from the s + l - human cells is recloned in dog, mink, and back int ... | 1975 | 18621353 |
| virus-specific dna sequences in mouse and rat cells transformed by the harvey and moloney murine sarcoma viruses detected by in situ hybridization. | 1975 | 163051 | |
| phosphoproteins: structural components of oncornaviruses. | oncornaviruses, which contain a virion-associated protein kinase, were found to possess phosphoproteins as virion structural components. one major phosphoprotein common to strains of laboratory and wild mouse oncornaviruses and a strain of feline leukemia virus was shown to be a polypeptide of about 12, 000 mol wt. in addition to this, the kirsten strain of murine sarcoma virus contained a second major phosphoprotein of about 10, 000 mol wt, and mouse erythroblastosis virus contained a second ma ... | 1975 | 163371 |
| a comparison of the effects of daunomycin and adriamycin on various dna polymerases. | the effects of the anthracycline antiboties, daunomycin and adriamycin, on the dna-directed activities of dna polymerases from murine sarcoma virus, rat liver (high-molecular-weight species), escherichia coli, and micrococcus luteus were determined. under all conditions tested, these compounds had greater inhibitory effect against the viral polymerase than against cellular polymerase. the inhibition of murine sarcoma virus dna polymerase by daunomycin was competitive with respect to dna. for vir ... | 1975 | 163690 |
| studies of fbj osteosarcoma virus in tissue culture. ii. autoinhibition of focus formation. | a high-titered non-focus-forming virus, fbj-mulv (murine leukemia virus), present in fbj tumor preparations, inhibited significantly the expression and production of fbj-musv (murine sarcoma virus) in tissue culture. this "autoinhibition" was comparable to that observed when a 3- to 4-log excess of infectious mulv was added to standard musv. the degree of inhibition was influenced by the tropism of the mulv (or the ease of spread and propagation of mulv in certain cells), multiplicity of infecti ... | 1975 | 164561 |
| aberrant viruses in cells infected with murine sarcoma virus-feline leukemia virus. | this study describes an unusual type of virus seen when a feline leukemia virus (felv) pseudotype of murine sarcoma virus (musv) obtained by cocentrifugation procedures infected feline embryo cells (fef) and two crandell cat cell lines (crfk1, crfk2). when all three cell cultures were infected with musv-felv, only fef and crfk2 were transformed and only these showed normal and aberrant virus. the crfk1 infected with musv-felv did not transform but did replicate normal type-c virus with a 50-a in ... | 1975 | 164569 |
| distribution of membrane particles and gap junctions in normal and transformed 3t3 cells studied in situ, in suspension, and treated with concanavalin a. | freeze-fracture techniques were used to study the ultrastructural distribution of plasma membrane particles in cultures of normal balb/c and swiss 3t3 and simian virus 40- or murine sarcoma virus-transformed fibroblasts. no apparent differences were observed. cultures fixed in situ show a seemingly random distribution of membrane particles both in normal or in transformed cells. treatment of cell cultures in situ with concanavalin a does not result in an altered pattern of particle distribution. ... | 1975 | 164659 |
| viral-related information in oncornavirus-lik particles isolated from cultures of marrow cells from leukemic patients in relapse and remission. | characterization of ribonucleic acid content of particles released from cultures of marrow cells of leukemic patients indicates the presence of rna molecules of size and base sequence characteristic of oncornarviruses. seventeen marrow samples obtained from leukemic patients in relapse or in a chronic phase of the disease yielded particles containing high-molecular-weight rna with a sedimentation velocity (about 70 s) similar to that obtained for murine oncornavirus rna. eight of nine marrow sam ... | 1975 | 164662 |
| non-producer human cells induced by murine sarcoma virus. | non-produces (np) human cells were isolated from transformed foci induced by the kirsten mouse sarcoma virus. these morphologically altered np cells produced neither infectious virus nor complement-fixing antigens of the murine sarcoma-leukemia virus complex. however, the sarcoma virus genome could be rescued from these nf cells by co-cultivation with cells carrying "helper" kirsten mouse leukemia virus or woolly monkey leukemia virus. the possible usefulness of these cells in efforts designed t ... | 1975 | 165148 |
| effect of protease inhibitors on focus formation by murine sarcoma virus. | the effect of six protease inhibitors, isolated from various species of actinomycetes, on focus formation by murine sarcoma virus was examined. pepstatin was the only inhibitor. the treatment of cells with pepstatin at various times possibly retards the early stage of infection with murine sarcoma virus. | 1975 | 165316 |
| development of a 3t3-like line from an embryo culture of an inbred strain of syrian golden hamster. | an embryo culture of an inbred strain of syrian hamster developed into a permanent cell line under the "3t3" 3 x 10-5 cells/60-mm dish. the resulting cell line had properties very similar to those of the mouse 3t3 series and was named hams 3t3. the cell showed density-dependent inhibition of division with a saturation density of 1.0 to 1.2 x 10-6 cells/60-mm dish or 4.5 to 5.5 x 10-4 cells/sq cm. addition of fresh medium containing 5 or 10% fetal calf serum to a confluent culture induced dna syn ... | 1975 | 165885 |
| effect of cordycepin on the replication of type-c rna tumor viruses. | cordycepin (3'-deoxyadenosine) was previously shown to inhibit virus production induced by iododeoxyuridine from murine fibroblasts (wu et al., 1972). we now report that the inhibitory effect of cordycepin results in a reduction of the number of cells producing virus as measured by the infectious center assay and fluorescent antibody technique. cordycepin has a much greater inhibitory effect on viral replication than on transformation of normal rat kidney cells by murine sarcoma virus since vira ... | 1975 | 166934 |
| effects of steroid hormones on replication of murine sarcoma virus in mouse embryo cultures. | the androgenic steroid hormone, testosterone, inhibited focus formation by the murine moloney sarcoma virus in mouse embryo cells. the inhibition of focus formation was enhanced by cyclic amp. although focus formation was inhibited, there was no inhibition of viral replication. the glucogenic adrenal corticosteroids, cortisol and dexamethasone, and 17-beta-estradiol and progesterone did not affect focus formation by musv(m). | 1975 | 167384 |
| sarcoma-negative leukemia-positive transformed cell culture established from a murine sarcoma virus-induced rat bone tumor. | inoculation of the soehner-dmochowski isolate of the moloney strain of murine sarcoma virus (msv), designated msv-sd, consistently leads to the development of bone tumors in the susceptible new zealand black (nb) rats. two separate cell cultures have been established from 2 individual msv-sd-induced nb rat bone tumors. cells of 1 bone tumor culture, designated rbt-e, are in early in vitro passages. these cells form colonies in agar medium and take up 2-deoxy-d-[3h]glucose at a greatly enhanced r ... | 1975 | 167960 |
| evaluation of the cell-mediated immune response to murine sarcoma virus by (125i)iododeoxyuridine assay and comparison with chromium 51 and microcytotoxicity assays. | the cell-mediated immune response of c57bl/6 mice to murine sarcoma virus (msv) was examined by the [125i]-iododeoxyuridine release cytotoxicity assay using msv-induced sarcoma tissue culture cell lines as target cells. cellular cytotoxicity was detected as early as 3 days after virus inoculation. most mice assayed between 12 and 17 days after msv inoculation gave positive results with maximum levels of activity present on days 13 and 14. reactivity was frequently detected for up to 100 days aft ... | 1975 | 167966 |
| heat sensitivity of murine sarcoma virus. | murine sarcoma virus (moloney) was found to be heat labile. inactivation curve represents a first-order kinetics at temperatures between 30 degrees and 60 degrees. inactivation constant analysis showed an inflexion at about 45 degrees, and the activation energy was calculated as 67.6 kcal/mol for higher temperature range and 7.95 kcal/mol for lower temperature range. nature of inactivation is also discussed. | 1975 | 168117 |
| secondary cell-mediated cytotoxic response to syngeneic mouse tumor challenge. | when c57bl/6 mice previously immunized with murine sarcoma virus (msv) were challenged with a rauscher virus-induced lymphoma, rbl-5, a secondary cell-mediated cytotoxic response could be detected by the cr release cytotoxicity assay. the level and distribution of the secondary cytotoxic response was affected by the route of challenge. animals injected i.p. demonstrated a high level of cytotoxicity in the peritoneal exudate cells 3 days after challenge and subsequently cytotoxicity was detected ... | 1975 | 168259 |
| murine sarcoma virus pseudotypes acquire a determinant specifying n or b tropism from leukaemia virus during rescue. | 1975 | 168499 | |
| transformation of cultured rat liver cells by murine sarcoma viruses. | cultured liver cells (trl-2 cells), originating from a bd-6 rat, an inbred black rat strain, and possessing several marker enzymes, and characteristic ultrastructures of hepatic cells, were infected with murine sarcoma viruses (msv: kirsten and gazdar strains). on day 5-6 after virus inoculation, the monolayered epithelial cells focally began to pile up forming small polypoid projections, and on day 7 round-shaped cells were released from the polypoid foci. these cells first grew in a chain or a ... | 1975 | 169808 |
| human amnion and lung tissue culture systems for possible detection and study of human rna tumor viruses. | a human lung and an amnion cell line were identified as highly susceptible to transformation by the rhabdomyosarcoma-114 (rd-114) virus pseudotype of murine sarcoma virus (msv). msv transformation on these two cell lines demonstrated a) "one-hit" kinetics with an msv stock which contained a 100-fold excess of msv over its detectable associate rd-114 helper virus and b) only a slight increase (2x) in focus-forming titers by the addition of optimal concentrations of rd-114 helper virus. these find ... | 1975 | 169818 |
| control of reversion of moloney virus sarcoma virus transformed cells. | mouse cells transformed by the moloney murine sarcoma virus (msv) native to the species can give rise to revertants which are supersusceptible to a second cycle of transformation. the msv retransformed cells can give rise to several complex functional states even after several cycles of cloning: a) formation of sarcoma positive, leukemia negative (s+lminus) type cells of which some sublines may be inducible for msv by halogenated pyrimidines; b) detection of initially sminuslminus cells which sp ... | 1975 | 169824 |
| in vivo interactions between murine leukemia and sarcoma viruses. | experiments have been performed with the aim of elucidating the nature and the extent of the in vivo interactions between murine leukemia viruses (mulvs) and murine sarcoma virus (msv). balb/c and cba mice, injected neonatally with graffi or passage a gross viruses (mulv-gi, mulv-g), have been inoculated as young adults with murine sarcoma virus, moloney strain (msv-m). a higher percentage of nonregressing sarcomas appeared in these animals, sometimes accompanied simultaneously by leukemia. the ... | 1975 | 169829 |
| genetic control of oncogenesis by murine sarcoma virus moloney pseudotype. i. genetics of resistance in akr mice. | infection of moloney mouse sarcoma virus (m-msv) in adult mice of several inbred strains revealed that all strains except akr are highly susceptible to m-msv tumor development. f1 hybrids between akr and cba, dba/2 or nih mice are as resistant (93%) as the parental akr strain, which indicates that resistance is transmitted as a dominant character. first backcross mice to the susceptible parent show a 3:1 ratio of resistant to susceptible mice. this is the expected ratio for two segregating loci ... | 1975 | 170219 |
| genetic control of oncogenesis by murine sarcoma virus moloney pseudotype. ii. a dominant epistatic susceptibility gene. | we have shown in the preceding paper that akr mice are highly resistant to m-msv tumor development, and that resistance is transmitted as a dominant character. in the present studies the tumor-response pattern of f1 hybrids between resistant akr and susceptible strains (c57bl/6, balb/c and b10br) following injection with moloney mouse sarcoma virus (m-msv) resembles that of the non-akr parent. segregation is observed in first backcross (bc1) and f2 mice, and the segregation ratios up to bc3 mice ... | 1975 | 170220 |
| clonal variation of the mouse cells in the endogenous c-type virus induction by 5-iodo-2'-deoxyuridine. | using an mlg cell line originating from a single newborn ddy mouse, n-tropic c-type virus able to infect the cells or origin was induced by 5-iodo-2'-deoxyuridine (iudr). all the clones isolated from the mlg cell line released the virus after iudr-treatment. there was more than a 100-fold difference in the virus inducibility between the highly and lowly inducible clones. the [125i]iudr incorporation was, however, the same for the both types of clones. when the induced virus was titrat-d in the s ... | 1975 | 170368 |
| murine xenotropic type c viruses i. distribution and further characterization of the virus in nzb mice. | the xenotropic mouse type c virus, originally detected in cultured embryo cells from new zealand black (nzb) mice, has been recovered from over 50 adult nzb animals and 15 nzb embryos. its presence is best detected by measuring its ability to rescue a murine sarcoma virus (msv) genome from a non-virus-producing msv-transformed rat cell. the virus can serve as a helper for replication of msv. it has a distinct type-specific coat and is a prototype for a third serotype of mouse type c viruses, nzb ... | 1975 | 170419 |
| adaptation of n-tropic friend leukaemia virus and its murine sarcoma virus pseudotype of non-permissive b-type c57bl/6 mouse cell line. | n-tropic friend leukaemia virus (flv) was serially passaged in a b-type c57bl/6 mouse cell line, yh-7. after a single passage, the infectious efficiency of flv in the restrictive yh-7 cells was significantly increased. this adapted character of flv could be reversed by a single passage in permissive n-type mlg cells. the true host range conversion from n to nb was accomplished after eleven to twelve passages in yh-7 cells. in contrast, the host range conversion of n-tropic murine sarcoma pseudot ... | 1975 | 171332 |
| two levels of restriction by mouse or cat cells of murine sarcoma virus coated by endogenous xenotropic oncornavirus. | mouse and cat cells were each examined for the mode of restriction of endogenous xenotropic oncornavirus. murine xenotropic helper virus (mux) and its pseudo-type of moloney murine sarcoma virus (msv(mux)) were grown in cat cells to high titre. mux alone did not replicate in any mouse cell tested including normal or transformed outbred swis 3t3 cells or sc-i cells, but did grow in a variety of other mammalian cells. msv(mux) was not able to achieve that intracellular state from which it could be ... | 1975 | 171336 |
| inhibition of in vitro growth of lymphoma cells by macrophages from tumor-bearing mice. | spleen cells from c57bl/6 mice bearing primary tumors induced by the moloney strain of murine sarcoma virus (musv) strongly inhibited the uptake of tritiated thymidine (3h-tdr) by rbl-5 lymphoma cells in a 48-hour growth-inhibition assay (gia). this activity was first detected 7 days after musv was injected; it peaked at 14 days, and was usually no longer detectable after 18-21 days. it could be detected at effector cell/target cell ratios between 20:1 and 5:1, at which normal spleen cells had a ... | 1975 | 171434 |
| requirement for cellular protein synthesis in reversal of ethidium-bormide-induced inhibition of cell transformation by murine sarcoma virus. | cultures of mouse balb 3t3 fibroblasts exposed to a noncytotoxic dose of ethidium bromide for 16-18 hr are unable to produce foci after infection with murine sarcoma virus. such cultures regain susceptibility to infection when incubated for 6-8 hr in drug-free growth medium. pretreated but not untreated cultures exhibit sensitivity toward brief (6 hr) exposure to cycloheximide, chloramphenicol, and actinomycin d before infection. pretreatment with cordy-cepin inhibits the ability of cultures to ... | 1975 | 172904 |
| tumorigenicity of virus-transformed cells in nude mice is correlated specifically with anchorage independent growth in vitro. | clonal isolates of mouse 3t3 cells and primary rat embryo cells, recovered nonselectively after infection by simian virus 40 (sv40), have been tested for tumorigenicity in the immune-deficient nude mice in order to determine the cellular growth properties in vitro specifically correlated with neoplastic growth in vivo. in addition, mouse 3t3 cells transformed by murine sarcoma virus (musv, kirsten strain), and revertants isolated from cells fully transformed by either sv40 or musv were also stud ... | 1975 | 172908 |
| radiation-enhanced murine sarcoma virus genome rescue activity. | although the doses of x-ray (312-2,500 r) used for irradiation of cells caused impairment of dna synthesis and cell replication, co-cultivation of x-irradiated mulv- carrier cells with un-irradiated nonproducer cells of msv-induced tumour resulted in as much as 20-fold increase in msv retrieval compared with the un-irradiated control. the enhancement was apparent also as a 3-fold increase in the number of cells producing msv (infectious centers) in the co-cultivation plate. this suggested that t ... | 1975 | 173498 |
| inhibition of oncornavirus functions by 2'-azido polynucleotides. | the 2'-azido analogs of poly(u) and poly(c), poly(duz) [poly(2'-azido-2'-deoxyuridylic acid)], and poly-(dcz [poly(2'-azido-2'-deoxycytidylic acid)], were found to inhibit the rna-directed dna polymerase (reverse transcriptase) activity of murine leukemia (moloney, rauscher) and sarcoma (moloney) virus, and feline leukemia (theilen) and sarcoma (gardner) virus, while under the same conditions the unsubstituted parent compounds failed to do so. in addition, poly(duz) and poly(dcz) inhibited the r ... | 1975 | 47174 |
| studies on virus induction by 5-bromodeoxyuridine in nonproducer murine sarcoma virus-transformed 3t3 cells. | 1975 | 49978 | |
| immunity to murine sarcoma virus induced tumours. iv. direct cellular cytolysis of 51cr labelled target cells in vitro and analysis of blocking factors which modulate cytotoxicity. | the antigen specific cell mediated cytotoxicity of msv immune spleen lymphocytes to 51cr labelled murine lymphoma cells was wholly abolished by pretreatment of the spleen cells with anti-theta antibody and complement. early during the immune response to msv the cytotoxic acitivity was inhibited by incubation of immune lymphocytes with "late progressor" or "early regressor" serum. immune lymphocytes at later times were more refractory to such inhibition by serum blocking factors. although unfract ... | 1975 | 50851 |
| partial characterization of c-type particles in a cell line (wr-9) derived from a rat epidermoid carcinoma of spontaneous origin. | a c-type virus continuously released from a cell line (wr-9) derived from a spontaneous epidermoid carcinoma was purified by means of large-scale tissue culture techniques and high-volume zonal centrifuges. with the use of relatively pure virus concentrates, partial characterization of the virus has been accomplished. up to 60 liters of spent culture medium from relatively low virus-yielding cultures were processed at a time through the model k ultracentrifuge in order to obtain quantities of vi ... | 1975 | 50883 |
| inhibition of purified dna polymerase of rna tumor viruses by fluoranthene derivatives and analogues of tilorone hydrochloride. | at concentrations of 7 times 10(-6) to 7 times 10(-5) m, derivatives consisting of the polycylic ring structures fluoranthene, fluorenone, fluorene, anthraquinone, xanthenone, and dibenzofuran with appropriate amine side chains inhibited by over 90% the purified rna-directed dna polymerase of avian myeloblastosis virus acting on poly(deoxyadenylate-deoxythymidylate) [poly(da-dt)]. of these, only the fluoranthene derivatives were strong inhibitors of the viral dna polymerase directed by polyadeny ... | 1975 | 51087 |
| characterization of murine sarcoma virus transformation of guinea pig cells and activation of an rna tumor-like virus from nonproducer guinea pig cells. | guinea pig embryo (gep) cells were transformed in vitro by the kirsten strain of mouse sarcoma virus (ki-msv). the transformed cells were found to release infectious virus continuously and produced high titers of group-specific (gs) complement-fixing (cf) antigen characteristics of the murine sarcoma-leukemia virus complex. foci of transformed cells were similar in appearance to those obtained with ki-msv in mouse and rat cells. the transformed cells produced rna dependent dna polymerase and typ ... | 1975 | 51621 |
| murine sarcoma virus defectiveness. viral polymerase expression murine and nonmurine host cells transformed by s+l-type murine sarcoma virus. | 1975 | 52940 | |
| secondary specific immune response in vitro to msv tumor cells. | the interactions which occur between antigenic tumor cells and normal or immune lymphoid cells in a 3-day in vitro culture, have been studied with a murine sarcoma virus (msv)-induced tumor. the 3h-thymidine incorporation of lymphoma cells growing in suspension, and the radioactive-chromium release of freshly sampled lymphoma cells regularly added to the culture, have been compared to determine the part played by immune lymphoid cells in cytolysis and cytostasis of the tumor-cell population. the ... | 1975 | 53210 |
| thermolabile reverse transcriptase of a mammalian leukemia virus mutant temperature sensitive in its replication and sarcoma virus helper functions. | three temperature-sensitive mutants of the rauscher strain of murine leukemia virus are defective in early post-penetration functions required both for leukemia virus infection and for initiation of transformation of cells by their pseudotypes of murine sarcoma virus. in the present study, the reverse transcriptase of one of these mutants (ts 29) is shown to be thermolabile compared with the enzymes of the wild-type virus and several other temperature-sensitive mutants. these findings provide ev ... | 1975 | 53294 |
| species and interspecies radioimmunoassays for rat type c virus p30: interviral comparisons and assay of human tumor extracts. | the major internal protein, p30, of rat type c virus (ralv) was purified and utilized to establish intra- and interspecies radioimmunoassays. three rat viruses were compared in homologous and heterologous intraspecies assays with no evidence of type specificity. the only heterologous viruses to give inhibition in these species assays were the feline (felv) and hamster (halv) type c viruses; these reactions were incomplete and required high virus concentrations. an interspecies assay using a goat ... | 1975 | 54444 |
| mouse msv transformed cells resistant to 8-azaguanine. | mouse cells transformed by murine sarcoma virus were made resistant to 8-azaguanine. resistant cells and cell clones isolated from them were deficient in hypoxanthine-guanine phosphoribosyl transferase (hgprt) activity. they did not grow in hatg medium, did not incorporate labeled hypoxanthine, and had negligible hgprt activity. the resistance was genetically stable. the resistant cells were hyperdiploid and contained telocentric chromosomes only. the resistant cells as well as the progenitor ce ... | 1975 | 55981 |
| inhibition of proliferation of lymphoma cells and t lymphocytes by suppressor cells from spleens of tumor-bearing mice. | we have recently demonstrated suppressor cells in spleens of mice bearing tumors induced by moloney murine sarcoma virus (msv) which were non-t cells and inhibited phytohemagglutinin molney (pha)-induced dna synthesis of syngeneic normal spleen cells. from the present study, the suppressor cells appeared to be macrophages since they were radioresistant, inactivated by carrageenan, and removed by adherence columns and an iron/magnet technique. we have also found that suppressor cells were still f ... | 1975 | 122986 |
| large round cell granulomas induced by murine sarcoma virus (moloney) in mouse brains. | the effect of murine sarcoma virus of moloney strain on central nervous system was examined morphologically in swiss mice of different age. a single intracranial inoculation of cell-free virus solution resulted in the induction of characteristic intracerebral granulomas in 82.8% of the newborn to 5 day-old group, in 71.4% of the 6 to 10 day-old group, and in 68.0% of the 11 to 20 day-old group. the mean latency periods to tumor recognition were 16.5, 21.1, and 33.5 days, respectively. the granul ... | 1975 | 128993 |
| [isolation of murine sarcoma virus not associated with xc plague forming leukemia virus]. | the n-type mlg cells transformed by b-tropic musv (wn1802b) produced defective musv without detectable among of mulv; the focus formation by the culture fluid required the co-infection of exogenous mulv. after one passage of the virus in mlg cells, we obtained a virus preparation which was capable of inducing foci without the exogenous mulv, but which remained negative in the xc test. | 1975 | 175971 |
| tumor inhibiting capacity of spleen and lymph node cells from mice with murine sarcoma virus (msv-m)-induced tumors. | the direct tumor inhibiting capacity of spleen and lymph node cells obtained from mice in different stages of moloney sarcoma virus (msv-m)-induced tumor development was studied. msv-m producing ascitic tumor cells with a tumor dosis50 of about 10(3) cells and a mean latent period--depending on the amount of transplanted cells--of6-12 days were used as target cells. they were mixed with dilutions of spleen and lymph node cells obtained from mice at various times after infection with msv-m. the c ... | 1975 | 181922 |
| [in vitro transmission of mouse leukemia virus to restrictive mouse cells: necessity for mixed infection by two different leukemia viruses]. | the plaque formation of murine leukemia virus (mulv) in non permissive mouse cells (n-tropic mulv in b-type cells, or b-tropic mulv in n-type cells) was increased by murine sarcoma virus whose plaque-forming activity was extremely low (musv xc-). the infection of n-tropic mulv in b-type cells was increased by musv xc- propagated only in n-type cells but not in b-type cells, and the infection of b-tropic mulv in n-type cells by musv xc- propagated only in b-type cells but not in n-type cells. | 1975 | 174827 |
| genetic control of oncogenesis by murine sarcoma virus moloney pseudotype. iii. possible correlation with endogenous virus production. | 1975 | 183715 | |
| primary and secondary in vitro generation of cytolytic t lymphocytes in the murine sarcoma virus system. | cell-mediated cytotoxic responses in vitro to surface antigens associated with murine sarcoma virus (msv)-induced tumors were investigated using mixed leukocyte-tumor cell cultures (mltc). the source of responding cells was either spleens from normal c57bl/6 mice (primary mltc) or spleens of c57bl/6 mice carrying or having rejected a msv-induced tumor (secondary mltc). graffi virus-induced gil-4 leukemia cells, rauscher virus-induced rb1-5 leukemia cells, and msv-induced msv-b16 sarcoma cells we ... | 1975 | 185057 |
| studies on the distribution and origin of cytolytic t lymphocytes present in mice bearing moloney murine sarcoma virus (msv)-induced tumors. | 1975 | 1085620 | |
| cell-mediated immunity to moloney sarcoma virus in mice. ii. analysis of antigenic specificities involved in t lymphocyte-mediated in vivo rejection of murine sarcoma virus-induced tumors. | sublethally irradiated balb/c mice innoculated with moloney sarcoma virus (msvm) develop progressively growing tumors and die within 30 days of virus innoculation. these animals can be protected from tumor progression (and death) by innoculation of small numbers of msv-immune t lymphocytes from msv-m innoculated (but unirradiated) animals. t lymphocytes in these donor animals have been shown to express immunity to a variety of viral and virally-induced antigens. we have investigated whether immu ... | 1975 | 1086221 |
| delayed tumour appearance and absence of regression in nude mice infected with murine sarcoma virus. | 1975 | 1110765 | |
| antibody-dependent lymphocyte cytotoxicity in the murine sarcoma virus system: activity of igm and igg with specificity for mlv determined antigen(s). | antisera with specificity for moloney leukemia virus-(mlv) determined antigen(s) were studied for their ability to induce mlv antigen bearing target cell reduction by lymphocytes in microcytotoxicity assays. sera from animals which had regressed moloney sarcoma virus (msv) tumors as well as sera from animals with progressively growing msv tumors were found to induce normal lymphocytes to be active against the targets. regressor serum was found also to induce cytotoxicity by immune lymphocytes fr ... | 1975 | 1117138 |
| some pathogenic aspects of murine sarcoma virus (moloney) in rats. | the oncogenic effect of the murine sarcoma virus (moloney) was tested in rats. host-age and virus-dose dependent variations in the pathogenic spectrum were found. four tumour "stages" were described: progressively lethal; lethal after long stationary period; complete tumour regression; tumour reoccurrence after complete regression. virus recovery was highest from the progressively growing tumours and in the reoccurred neoplasms, while no virus was found in stationary tumours or in those sites ... | 1975 | 1117696 |
| murine sarcoma virus related nucleic acid sequences in a non-transforming virus derived from an interspecies pseudotype sarcoma virus. | a number of sarcomagenic viruses recovered from hamster tumors induced originally by moloney sarcoma virus or several of its mouse pseudotypes appear to be interspecies pseudotypes with structural proteins of hamster type-c viruses and nucleic acid sequences of both mouse and hamster specificity. a non-transforming virus (gloh-minus) recovered from a sarcomagenic virus preparation obtained from a tumor induced by the gross pseudotype of moloney sarcoma virus was previously shown to retain mouse ... | 1975 | 1140876 |
| [histopathologic and ultrastructural study of tumors induced by murine sarcoma virus (msv) (author's transl)]. | various growth phases of moloney murine sarcoma virus (m-msv) induced tumors in suckling and young adult balb/c mice have been studied by light and electron microscopy. in the early phase (3-6 days following m-msv), observations at the injection site of the thigh muscles consisted of endo- and perimysial edema "activated" muscle satellite, cells, endothelial cells and fibroblasts, scattered type c virus particles within the muscle fibers, muscle fibers and endomysial cells undergoing necrosis an ... | 1975 | 1226574 |
| search for nucleic acid sequences complementary to a murine oncornaviral genome in poly(a)-rich rna of human leukemic cells. | the presence of viral-like sequences in the rna of various types of leukemic cells was investigated by hybridizing cellular poly(a)-containing rna with cdna synthesized in an endogenous system of purified moloney murine sarcoma virus [m-msv-(mlv)]. poly(a)-rna-cdna hybrids were detected by assaying their resistance to s1 nuclease. hybrids were found in 22 out of the 46 leukemias that were tested. none of the controls, including material obtained from buffy coats, bone marrow cells, and a continu ... | 1975 | 1061078 |
| tumor induction by moloney sarcoma virus in athymic nude mice. | athymic nude (nu/nu) mice, normal nmri (plus/plus) mice, and nu/plus heterozygotes, inoculated at birth with the moloney strain of murine sarcoma virus (m-msv), did not differ either in tumor growth rate or incidence or in mortality due to tumor development; neither did nude (nu/nu) and normal nmri mice inoculated with m-msv at 30 days of age differ in the initial tumor growth rate. however, tumors induced in adult nude mice grew progressively and eventually killed the hosts, whereas tumors indu ... | 1975 | 1078700 |
| two functionally distinct anti-tumor effector cells isolated from primary murine sarcoma virus-induced tumors. | the ability of cells from primary msv-induced tumors to function as effector cells in vitro was evaluated. host cells were isolated by enzymatic disaggregation of the tumor and fractionated by sedimentation velocity at unit gravity on a ficoll gradient. characterization of these cells indicated that 30 to 40 % were t lymphocytes, about 50% were macrophages and less than 5% were b lymphocytes. two different functional activities were mediated by these cells: cytolysis, as measured by the cra, and ... | 1976 | 1084897 |
| virus-induced osteosarcoma in rats. | an experimental model for osteosarcoma was developed in which, after moloney murine sarcoma virus was injected into the tibial marrow space of three strains of inbred neonatal rats, a highly malignant neoplasm arose within ten days. this tumor was readily maintained in tissue culture and was transplantable to adult rats. it arose in the metaphyseal marrow of several bones, was locally invasive, metastasized to the lungs, and histologically resembled osteosarcoma. | 1976 | 1063127 |
| immunogenicity of virus-induced rat osteosarcoma. | the immunogenicity of a virus-induced rat osteosarcoma was studied utilizing the lymphocyte microcytotoxicity test. intratibial injection of murine sarcoma virus (moloney) resulted in the development of palpable tumors at the injection site which on histopathological examination appeared to be osteosarcomas. in 73 per cent of animals injected these tumors progressed and metastasized to the lungs. lymphocytes from these "progressor" animals demonstrated an ability to kill osteosarcoma cells in vi ... | 1976 | 1063128 |
| mixed lymphocyte/tumor-cell interaction in a murine sarcoma virus (moloney)-induced tumor system. comparison between lymphoproliferation and lymphocyte cytotoxicity. | studies of the mlti were performed in a primary msv-induced tumor system. reactivity against mitomycin-c-treated rbl-5 cells could be detected during a limited period at about 14 days after virus injection. the degree of reactivity of msv 14 spleen cells was quite variable; stimulation indices ranged from 2.2 to 9.4. activity in the mlti appeared to a great extent to be dependent on t-lymphocytes. a relatively broad spectrum of specificity was demonstrated in experiments using additional stimula ... | 1976 | 1254360 |
| inhibition of cell-mediated cytotoxicity against tumor-associated antigens by suppressor cells from tumor-bearing mice. | spleen cells from mice bearing primary tumours induced by moloney strain of murine sarcoma virus (m-musv) strongly inhibited the in vitro generation of specific secondary cell-mediated cytotoxic response of spleen cells from m-musv regressor mice. these suppressor cells were resistant to treatment with anti-theta serum and complement or to x-irradiation. it appeared that suppressor cells may have had a role in limiting the host's immune response against tumor growth. | 1976 | 1255803 |
| elimination of the sarcoma genome from murine sarcoma virus transformed cat cells. | cat cells transformed by moloney murine sarcoma virus contain virus-specific sequences in their rna and dna. cloned, spontaneous revertant cell lines derived from clones of these cells had no evidence of the sarcoma genome in the cell rna or dna as judged by rna-complementary dna or dna-complementary dna hybridizations. ?this is apparently the first report of loss of a transforming genome in a revertant cell line. | 1976 | 1257745 |
| morphological, biological, immunological and biochemical studies on bone tumors of animals and man. | biological studies on fbj osteosarcoma virus in tissue cultures have led to the isolation of murine sarcoma virus. characteristic type c-mulv particles were observed in bone tumors induced by the sd-msv-m-virus in vitro and in vivo. the sd-msv-m virus also induced bone tumors in rats of all strains tested, and it has a similar tumor-inducing property in hamsters. immunoelectronmicroscopic studies showed that envelope antigens of msv-sd virus in rat bone tumors can be distinguished from those fou ... | 1976 | 189370 |
| immunogenic properties of a nonproducer malignant tumor induced by murine sarcoma virus. | a cloned cell line h-11 (hp) derived from an msv-induced neoplasm (a hemangiosarcoma) was found to possess virus-specific tumor rejection antigen(s). the specific nature of the immune response was established through the use of a polyoma virus-induced neoplasm no. 89 both in cross immunization and cross challenge experiments. virus antigens or surface antigens associated with virus production are not responsible for tumor rejection since virus production could not be detected, nor were any viral ... | 1976 | 967890 |
| malignant transformation and viral replication of rat bone and muscle cells after in vitro infection with rat-adapted murine sarcoma virus (moloney). | isolated bone and muscle cells from rat fetuses were infected with the rat-adapted osteosarcomogenic murine sarcoma virus (moloney) for examination of malignant transformation and viral replication. after the infection, the bone cells underwent an unusual transformation characterized by two patients in the focus formation. in the early transformation (transformation i), foci consisting of only morphologically altered cells appeared, but they soon disappeared. focus formation of this type continu ... | 1976 | 975041 |
| suppression of moloney sarcoma virus immunity following sensitization with attenuated virus. | murine sarcoma virus (moloney strain) (msv-m)-induced tumors are unusual in that they regularly appear less than 2 weeks after virus inoculation, progress for 1 to 2 weeks, and are rejected by normal adult balb/c mice. rejectio leaves the animals immune to tumor induction. in the present study, presensitization of normal adult balb/c mice with attenuated msv-m resulted in an altered pattern of tumor immunity. injection of active msv-m into the presensitized animals resulted in tumor induction an ... | 1976 | 1000500 |
| reduced transplantability of syngenic mouse tumors superinfected with membrane viruses in nu/nu mice. | transplantability of mouse tumors superinfected with various kinds of membrane viruses was investigated in syngeneic hosts. methylcholanthrene-induced fibrosarcomas in balb/c mice, meth a, and in c57bl/6 mice, bmt-, superinfected with friend lymphatic leukemia virus in mice given neonatal injection of the virus, grew more slowly than uninfected tumors. the retardation of growths was not observed in mice that had been given injections of the virus at birth. similarly, meth a and a hepatoma in c3h ... | 1976 | 1006777 |
| nucleotide sequences in mouse dna and rna specific for moloney sarcoma virus. | complementary dna (cdna) synthesized by moloney murine sarcoma virus (m-msv) was separated into two parts, the first, termed msv-specific cdna, composed of nucleotide sequences found only in m-msv viral rna, and the second, termed msv-mulv common cdna, composed of nucleotide sequences that were found in both m-msv and murine leukemia virus (mulv) viral rnas. rna complementary to the msv-specific cdna was not found in several other msv isolates, nor in ecotropic mulv, mouse mammary tumor virus, o ... | 1976 | 185623 |
| antigenic specificity of the cytolytic t lymphocyte (ctl) response to murine sarcoma virus-induced tumors. i. preferential reactivity of in vitro generated secondary ctl with syngeneic tumor cells. | incubation of spleen cells from mice having rejected a moloney sarcoma virus (msv)-induced tumor with syngeneic irradiated lymphoma or sarcoma cells bearing msv-associated antigens in secondary mixed leukocyte-tumor cell cultures (mltc) resulted in the generation of highly active cytolytic t lymphocytes (ctl) specifically directed against syngeneic target cells bearing msv-associated antigens. when msv-immune spleen cells from c57bl/6 (h-2b) and balb/c(h-2d) mice were compared with respect to th ... | 1976 | 187429 |
| antipyretic and antiviral action of vitamin a in moloney sarcoma virus- and poxvirus-inoculated mice. | six week-old male cba/j mice fed a commercial powdered laboratory chow or the same chow supplemented with vitamin a palmitate (150,000 u/kg) were inoculated with either the moloney strain of murine sarcoma virus (m-musv) or poxvirus. central body temperature was measured daily. both viruses elicited fevers, but the fevers were less pronounced and of shorter duration in the mice ingesting the vitamin a-supplemented diet. palpable m-musv-induced tumors appeared later, were less frequent, grew more ... | 1976 | 187770 |
| evaluation of moloney murine sarcoma and leukemia virus complex as a model for airborne oncogenic virus biohazards: survival of airborne virus and exposure of mice. | aerosols of the moloney murine sarcoma virus (musv-m) and leukemia virus (mulv-m) complex (musv-m/mulv-m) were generated from refluxing atomizers and then aged in rotating drums at 21 degrees c holding temperature with relative humidities ranging from 25 to 76%. the musv-m and mulv-m aerosolized from the same tumor extract preparation survived almost equally at the four humidity levels. both viruses remained viable in the airborne state for at least 2 hours after aerosolization. when mice were e ... | 1976 | 187776 |
| rapid screening assay for revertants of murine sarcoma virus-transformed cells. | 1976 | 187898 | |
| prevention of spontaneous leukemia in akr mice by type-specific immunosuppression of endogenous ecotropic virogenes. | akr/j mice, 80-90% of which ordinarily die of spontaneous lymphocytic leukemias by 12 months of age, were significantly protected from developing leukemia in the initial experiment by a single course of treatment with akr serotype-specific antibodies mad in goats and processed as immune gamma globulin (igg). in experiment 1, igg was given on the day of birth and on four additional days, and finished on day 14. this schedule resulted in suppression of over 4 logarithms of normal virogene expressi ... | 1976 | 188047 |
| susceptibility of xeroderma pigmentosum cells to transformation by murine and feline sarcoma viruses. | among various strains of skin fibroblasts tested, two strains derived from xeroderma pigmentosum (xp) patients (ages 19 and 25) with neurological complications and two strains obtained from heterozygotes (ages 54 and 18) showed relatively higher susceptibility than normal age-matched controls to transformation by feline sarcoma virus (fsv). only one strain from a normal individual also showed a high susceptibility. generally, there was a parallelism in susceptibilities to fsv and kirsten murine ... | 1976 | 184947 |
| attempts to induce tubular deformations and subsequent mixed tumours from organotypic cultures of mouse renal mesenchyma. | with the aim of expanding knowledge on the pathogenesis of nephroblastomata, an embryological organ culture system (grobstein, 1956) was tested for its applicability to in vitro carcinogenesis experiments by using murine sarcoma virus (msv-m) and 3-methylcholanthrene (mca). treatment of cba/h-t6 mouse metanephrogenic mesenchyma with msv-m at the pretubular stage neither disturbed the glomerulogenesis nor induced rapid malignant transformation. treatment of the same tissues with mca considerably ... | 1976 | 175592 |
| preliminary evidence for novel fucose-containing lipids in normal and murine sarcoma virus-transformed rat cells. | 1976 | 175795 | |
| fucolipid metabolism as a function of cell population density in normal and murine sarcoma virus-transformed rat cells. | the incorporation of isotopically labeled fucose into the lipids of normal and murine sarcoma virus-transformed rat cells as a function of cell population density was examined. when normal cells were seeded at low cell density, the levels of the major fucolipids, i.e., fucolipids iii and iv, were substantially reduced, but then they increased as the cells approached confluency. this variation in synthesis of fucolipids iii and iv appeared to be primarily related to cell density and not to cell g ... | 1976 | 182264 |
| glycolytic enzyme activities in murine sarcoma virus-transformed cultures of balb 3t3. the role of culture density. | 1976 | 183120 | |
| increased ornithine decarboxylase activity in murine sarcoma virus infected cells. | 1976 | 183140 | |
| the correlation of plasma membrane microvilli and intracellular cyclic amp content in a rat epitheloid kidney cell line. | modulation of the intracellular concentration of cyclic amp has been associated with a regulatory role in cell division, cell morphology, and physical properties of the plasma membrane. untransformed rat kidney cells in culture exhibit epitheloid morphology, high intracellular cyclic amp levels, and contact inhibition of growth. untransformed rat kidney cells transformed with the kirsten murine sarcoma virus exhibit a low cyclic amp content, rapid growth rate, and a loss of contact inhibition. s ... | 1976 | 191699 |
| immune reactivity in the moloney strain of murine sarcoma virus oncogenesis: requirement of thymus-derived lymphocytes for in vivo protection. | to study the function of different lymphocyte populations in the moloney strain of murine sarcoma virus (m-musv) tumorigenesis, we gave m-musv injections to cba mice selectively deprived of thymus (t) lymphocytes by thymectomy, x-rradiation, and syngeneic bone marrow injection. although no tumors appeared in the control group, 80% of the derived mice had tumors that grew progressively and ultimately killed them. in deprived mice, grafted with a syngeneic thymus (reconstituted mice) before or aft ... | 1976 | 176399 |
| rat sequences of the kirsten and harvey murine sarcoma virus genomes: nature, origin, and expression in rat tumor rna. | two murine sarcoma viruses, the kirsten and the harvey, were isolated by passage of mouse type c leukemia viruses through rats. these sarcoma viruses have genomes containing portions of their parental type c mouse leukemia virus genomes, in stable association with specific rat cellular sequences that we find to be quite likely not those of a rat type c leukemia virus. to determine if these murine sarcoma viruses provide a model relevant to the events occurring in spontaneous tumors, we have hybr ... | 1976 | 176419 |
| genomic complexities of murine leukemia and sarcoma, reticuloendotheliosis, and visna viruses. | the genetic complexities of several ribodeoxyviruses were measured by quantitative analysis of unique rnase t1-resistant oligonucleotides from 60-70s viral rnas. moloney murine leukemia virus was found to have an rna complexity of 3.5 x 10(6) daltons, whereas moloney murine sarcoma virus had a significantly smaller genome size of 2.3 x 10(6). reticuleondotheliosis and visna virus rnas had complexities of 3.9 x 10(6), respectively. analysis of rnase a-resistant oligonucleotides of rous sarcoma vi ... | 1976 | 176429 |
| an improved assay for feline leukaemia virus pseudotypes of murine sarcoma virus. | an assay is described for feline leukaemia virus pseudotypes of murine sarcoma virus which increased the virus titre by about 100-fold over conventional assays. the titre is independent of dilution and no secondary focus formation occurs. the assay may be used to study virus neutralization and to detect and type feline leukaemia virus in feline embryo cells by interference. | 1976 | 177726 |
| fractionation of dna nucleotide transcripts from moloney sarcoma virus and isolation of sarcoma virus-specific complementary dna. | radioactive dna complementary to nucleotide sequences in moloney murine sarcoma virus (msv) and moloney leukemia virus (m-mulv) complex was made by the endogenous reverse transcriptase reaction. these virus stocks contained a threefold excess of msv over m-mulv as measured by biological assay. the complementary dna was an accurate copy of the viral rna in that 86% of 35s viral rna hybridized with complementary (cdna) dna at a 1.5 to 1 cdna-rna molar ratio. the complementary dna, of a 4-6s size, ... | 1976 | 178890 |
| retransformation of a thermosensitive balb/c-3t3 transformant by murine sarcoma virus at the non-permissive temperature. | 1976 | 179009 | |
| suppression of mixed lymphocyte response in mice bearing primary tumors induced by murine sarcoma virus. | mixed lymphocyte culture (mlc) responses of spleen cells from mice bearing tumors induced by murine sarcoma virus of the moloney type (msv) against allogeneic spleen cells were found to be markedly depressed, as estimated by three parameters: lymphoblast counts, 3h-thymidine incorporation (ti), and cell-mediated lysis (cml). while all three parameters were definitely depressed in comparison to the normal controls, ti was depressed to a greater degree than lymphoblast counts and cml. msv spleen c ... | 1976 | 179171 |
| characterization of effector lymphocytes associated with immunity to murine sarcoma virus (msv) induced tumors. i. physical properties of cytolytic t lymphocytes generated in vitro and of their immediate progenitors. | cytolytic t lymphocytes (ctl) were generated in secondary mixed leukocyte-tumor cell cultures (mltc) with syngeneic rb1-5 tumor cells as stimulating cells and with responding spleen cells from regressor mice that had rejected a murine sarcoma virus (msv)-induced tumor. ctl precursor cells were found to be exclusively of thymic origin and non-t cells were apparently not required for ctl generation. when the size variations of ctl from syngeneic mltc were analyzed by velocity sedimentation it appe ... | 1976 | 180182 |
| inhibition of murine sarcoma virus induced transformation by adenovirus structural proteins. | the purified fibre and hexon of adenovirus 12 inhibit the transformation in tissue culture of murine sarcoma virus (msv-m) by as much as 80% and 70%, respectively, when they are added to cells 8 to 2o h before msv-m infection. during a 12 h period, only about 6 to 8% of added radiolabelled viral proteins become associated with cells (or i-o mug protein bound/10(5) cells). no inhibition occurs when the proteins are added simultaneously with msv-m or 90 min or 4 h after msv-m. there is also a dire ... | 1976 | 180250 |
| phenotypic mixing between n- and b-tropic murine leukemia viruses: infectious particles with dual sensitivity to fv-1 restriction. | in effort to understand how n or b tropism is determined in murine leukemia virus (mulv) particles, we analyzed the mulv produced after dual infection of mouse cells by n- and b-tropic mulv. the progeny mulv from such a mixed infection are sensitive to fv-1 restriction in both n- and b-type cells, but are still highly infectious for mouse cells which do not exhibit fv-1 restriction. this dual sensitivity to fv-1 restriction is a phenotypic property of mulv produced by mixedly infected cells, sin ... | 1976 | 181144 |
| the pathology of brain tumors induced by murine sarcoma virus, moloney strain. | murine sarcoma virus, moloney strain, was inoculated intracerebrally into 75 spraque-dawley rats within 24 hours after birth. of 48 rats examined histologically within 35 days after virus inoculation, most developed granulomatous lesions in the meninges or in the cortex and in the glial nodules of the subependymal region, or in all these regions. the granulomatous lesions first appeared 8 days after virus inoculation and reached a peak about 30 days after virus inoculation. thereafter, the lesio ... | 1976 | 137651 |
| cell-mediated immunity to leukemia virus- and tumor-associated antigens in mice. | cell-mediated immune reactions appear to play an important role in resistance against growth of leukemia cells in mice. possible mechanisms for in vivo protection in two tumor systems are discussed. these tumor models, which are a friend leukemia virus-induced transplantable tumor, fbl-3, and primary murine sarcoma virus (msv) -induced tumors, are strongly antigenic; under some conditions, tumors regress completely. in mice with regressing fbl-3 tumors, cell-mediated cytotoxicity was measured by ... | 1976 | 56223 |