Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| frequency and significance of antibody to hepatitis c virus in severe corticosteroid-treated autoimmune chronic active hepatitis. | to determine the frequency and significance of antibody to hepatitis c virus (anti-hcv) in severe autoimmune chronic active hepatitis, we tested sera from 85 cortico-steroid-treated patients by an enzyme immunoassay. seropositive patients were assessed for specific antibodies to hepatitis c virus-encoded antigens by recombinant immunoblot assay. the findings in patients with and without anti-hcv were contrasted, and the frequency of seropositivity was compared with that in patients who had other ... | 1991 | 1646353 |
| hepatitis c virus antibody in patients with chronic autoimmune hepatitis: pitfalls in diagnosis and implications for treatment. | 1991 | 1646354 | |
| histological outcome in interferon alpha-2b treated patients with chronic posttransfusion non-a, non-b hepatitis. | the histological outcome in liver biopsies following 9 months of interferon alpha-2b treatment was assessed in detail in 19 patients with chronic posttransfusion non-a, non-b hepatitis (pth-nanb) and compared with 12 untreated pth-nanb patients. fourteen (74%) treated and 7 (58%) control patients were reactive for antibodies against hepatitis c virus (anti-hcv). liver biopsies taken before and after the 9-month period were scored numerically for portal inflammation, piecemeal necrosis (pmn) and ... | 1991 | 1646369 |
| prevalence of antibodies to hepatitis c virus in sera from patients with systemic necrotizing vasculitis. | 1991 | 1646410 | |
| [prevalence of antibodies to hepatitis c virus in a population of south eastern france infected with hiv]. | 1991 | 1646450 | |
| prevalence of non-a, non-b hepatitis/hepatitis c virus antibody in laboratory quality-assurance sera. | quality-assurance sera (qas) are prepared from pooled sera composed of thousands of individual donations. previous studies documented that a substantial percentage of individual qas test positive for viral disease markers, including antibodies to human immunodeficiency virus and to hepatitis b surface antigen. we tested 239 qas from various proficiency programs and commercial sources to determine the prevalence of hepatitis c virus (hcv) antibody. we tested samples for anti-hcv by using an enzym ... | 1991 | 1646689 |
| antibodies to hepatitis c virus in community-acquired acute non-a, non-b hepatitis. | circulating antibodies to the recently identified hepatitis c virus (anti-hcv) have been investigated by elisa in a series of 129 adult italian patients with acute, community-acquired non-a, non-b hepatitis. anti-hcv was detected in 50 (38%) cases with a prevalence rate which increased from 19%, in sera taken during the first 2 weeks of illness to 52% in samples obtained 5-6 weeks after onset, indicating a rather late appearance of the antibody. anti-hcv positivity was independent of risk factor ... | 1991 | 1646835 |
| antibodies to hepatitis c virus and response to interferon treatment in non-a, non-b chronic hepatitis. | 1991 | 1646837 | |
| anti-hcv antibodies detected by elisa in autoimmune and cryptogenic chronic liver disease. | 1991 | 1646838 | |
| antibody to the hepatitis c virus in acute hepatitis and chronic liver diseases in japan. | in a 6-month follow-up study of acute hepatitis in japan, 31 out of 41 (75.6%) cases of post-transfusion non-a and non-b hepatitis (nanb-pth) and 14 out of 40 (35.0%) cases of sporadic non-a non-b hepatitis (nanb-spo) were found to be positive for antibody to the hepatitis c virus (hcvab). after 12 months of follow-up, 30 cases (81.1%) became chronic among 37 hcvab positive acute nanb hepatitis cases. this figure shows a significantly higher rate of chronicity as compared with hcvab negative acu ... | 1991 | 1646928 |
| seroconversion for hepatitis c virus antibody in bone marrow recipients treated with immune globulin. | 1991 | 1646961 | |
| a long-term study of hepatitis c virus replication in non-a, non-b hepatitis. | although antibodies to the hepatitis c virus (hcv) are known to be associated with non-a, non-b hepatitis, little is known about the pattern of hcv replication, its relation to antibody levels, and the clinical course of non-a, non-b hepatitis. | 1991 | 1646962 |
| virus safety of pasteurized antithrombin iii concentrate. | 1991 | 1647061 | |
| antibody to hepatitis-c-virus-related proteins in sera from alanine-aminotransferase-screened blood donors and prospectively studied recipients. | a prospective study of posttransfusion non-a, non-b hepatitis was conducted in malmö, sweden, in 1984-1985, in which donors were alanine aminotransferase (alt) screened but not alt selected. among 741 patients studied at 0, 6, and 12 weeks after transfusion, 13 developed non-a, non-b hepatitis, and these were further followed up. stored sera from the 13 hepatitis patients and their 123 donors were tested for anti-hepatitis c virus (hcv) by elisa and if positive, analyzed by recombinant immunoblo ... | 1991 | 1647082 |
| assessment of hepatitis c antibody tests in homosexual men with hyperglobulinemia. | 1991 | 1647424 | |
| [antibodies against hepatitis c in african leprotic patients]. | 1991 | 1647529 | |
| [non-a, non-b hepatitis: advances in diagnosis and therapy]. | the characterization of the hepatitis c virus (hcv) and the development of an anti-hcv antibody test have closed a further gap in the etiological diagnosis of viral hepatitis, but at the same time new questions have been raised. it has been shown that hcv is by far the most frequent source of the parenterally transmitted form of non-a, non-b hepatitis (nanbh). the anti-hcv test is reactive in the majority of cases with chronic nanbh. however, seroconversion is delayed by weeks or even months and ... | 1991 | 1647547 |
| [prevalence and significance of ant-hcv-antibodies in ambulatory patients with raised transaminases]. | from november 1989 to april 1990 we analyzed prospectively the prevalence of anti-hepatitis c virus antibodies and the possible mode of infection in 90 outpatients with repeatedly elevated alanine-aminotransferase levels. the clinical and serological course of these patients was evaluated after 1, 3 and 6 months. initially, 24 patients (26.6%) were positive for anti-hcv antibodies, but subsequently only 14 of these patients (15.5%) were positive in the follow-up tests. 9 patients (10%) showed no ... | 1991 | 1647550 |
| hepatitis c virus not found in fulminant non-a, non-b hepatitis. | 1991 | 1647717 | |
| hepatitis c virus: evidence for sexual transmission. | to determined the prevalence of hepatitis c virus infection and associated risk factors in patients attending a genitourinary medicine clinic, as evidence for sexual transmission. | 1991 | 1647826 |
| gene mapping of the putative structural region of the hepatitis c virus genome by in vitro processing analysis. | processing of the putative structural proteins of hepatitis c virus was examined by using an in vitro expression system. an rna transcript for cell-free translation was prepared from a cdna construct that encompasses the region encoding the 980 amino-terminal residues of the viral polyprotein precursor. processing of the in vitro translation product proceeded cotranslationally in the presence of microsomal membranes and generated four major membrane-associated products. two of these four major p ... | 1991 | 1648221 |
| hepatitis c viral rna in serum of patients with chronic non-a, non-b hepatitis: detection by the polymerase chain reaction using multiple primer sets. | the recently introduced antibody test for hepatitis c virus infection has already proved to be valuable in many situations such as screening blood donors and diagnosing chronically infected patients, but this antibody assay has certain limitations. hepatitis c virus itself is usually present in clinical specimens at very low titers; therefore a useful assay for the virus must have very high sensitivity. we have developed a simple, highly sensitive assay for hepatitis c virus rna based on the pol ... | 1991 | 1648539 |
| the significance of antibody to hepatitis c virus in patients with chronic hepatitis b. | we assessed the prevalence and clinical significance of antibodies to hepatitis c virus among a cohort of 148 patients with chronic hepatitis b virus infection. sixteen patients (11%) had anti-hepatitis c virus detectable by enzyme-linked immunoassay. the results from eight of these patients were positive by recombinant immunoblot assay. the results of recombinant immunoblot assay testing were not consistent; therefore the analysis of the patients' data was based on anti-hepatitis c virus enzyme ... | 1991 | 1648540 |
| isolation of a complementary dna fragment of hepatitis c virus in taiwan revealed significant sequence variations compared with other isolates. | to clone and characterize hepatitis c virus strains present in taiwan, rna was extracted from liver tissue collected from a patient during the acute phase of posttransfusion non-a, non-b hepatitis. rna was then subjected to complementary dna synthesis and the polymerase chain reaction, using primers derived from the original nucleotide sequence of the united states hepatitis c virus strain. a complementary dna clone, hcv-t3, containing 552 base pairs of hepatitis c virus complementary dna sequen ... | 1991 | 1648541 |
| detection of antihepatitis c virus antibody in severe epstein-barr virus-induced hepatitis. | 1991 | 1649223 | |
| neopterin as a marker of c hepatitis in thalassaemia major. | the authors studied serum neopterin in 106 patients with beta thalassaemia major. a good correlation was found between neopterin values and glutamic pyruvic transaminase (gpt) mean values of the last 6 months, whereas no correlation was found between neopterin values and some siderosis indexes (iron/body weight, total accumulated iron). a statistically significant correlation was found between neopterin values (greater than 10 nm/l vs. less than 10 nm/l) and histological liver findings (chronic ... | 1991 | 1649287 |
| transmission of hepatitis c virus by organ transplantation. | liver disease is a frequent and major complication after organ transplantation. we sought to determine whether hepatitis c virus (hcv) is transmitted by organ transplantation and whether it causes post-transplantation liver disease. | 1991 | 1649402 |
| hepatitis c virus. another agent transmitted by transplanted organs. | 1991 | 1649405 | |
| [hepatitis c virus antibody in hungarian blood donors, persons at risk and patients with post-transfusion hepatitis]. | the authors screened blood donors, persons at high risk of infection and patients with post-transfusion hepatitis by the use of the new hepatitis c antibody test. 1.7% of persons donating blood acceptable for use according to current criteria were found positive. this ratio was markedly higher among donors displaying an elevated transaminase level. among the various patients tested 85% of the haemophiliacs, 14% of the transfused haematology patients, and 40% of those on dialysis were found posit ... | 1991 | 1649426 |
| low prevalence of hepatitis c antibodies in chronic liver disease in finland. | high prevalence of hepatitis c antibodies (anti-hcv) have been found in the middle- and southern european countries in connection with chronic liver diseases. in a study of finnish chronic liver disease patients no anti-hcv antibodies were found in 22 autoimmune chronic active hepatitis, in 5 chronic persistent hepatitis and in 38 alcoholic liver disease patients. 2/30 primary biliary cirrhosis patients were anti-hcv positive. as a comparison 3/9 patients with acute community acquired non-a non- ... | 1991 | 1649492 |
| mother-to-child transmission of hepatitis c virus. | 1991 | 1649878 | |
| interferon therapy for acute posttransfusion non-a, non-b hepatitis: response with respect to anti-hepatitis c virus antibody status. | to assess the effect of interferon therapy on posttransfusion non-a, non-b acute hepatitis, we examined the appearance of serum hepatitis c virus antibody (anti-hcv) and abnormal serum aminotransferase levels after the onset of hepatitis in 12 patients treated with interferon and in 46 patients treated conservatively. eleven patients were given 3 million units of human fibroblast beta-interferon three times weekly for 4 wk and 1 was given one million units of human lymphoblastoid alpha-interfero ... | 1991 | 1650129 |
| detection and partial sequencing of hepatitis c virus rna in the liver. | to detect hepatitis c virus rna, total rna was extracted from liver tissue, reverse transcribed to complementary dna, and amplified by polymerase chain reaction. the reaction products were analyzed by ethidium bromide staining in acrylamide gel and hybridization with a radiolabeled probe. hepatitis c virus rna was thereby detected in 17 of 27 (63%) liver tissue specimens obtained from patients with non-a, non-b chronic liver diseases. of these 27 patients, viral rna was detected in 12 of 17 (71% ... | 1991 | 1650319 |
| prevalence of antibody to hepatitis c virus among saudi arabian children: a community-based study. | in a population-based survey, 39 (0.90%) of 4,496 saudi arabian children (ages 1 to 10) were positive for antibody to hepatitis c virus. no significant difference was seen between the prevalence rate in males (0.9%) and females (0.8%) or between urban (0.7%) and rural dwellers (1.0%). a significant variation of rates (0% to 5.7%) was seen from one region to another. the gizan population, noted for hyperendemic hepatitis b virus infection, had the highest prevalence of antibody to hepatitis c vir ... | 1991 | 1650324 |
| molecular biology of the hepatitis c viruses: implications for diagnosis, development and control of viral disease. | 1991 | 1650328 | |
| prevalence of anti-hepatitis c virus seroconversion in polytransfused thalassemic patients. | 1991 | 1650514 | |
| prevalence of hepatitis c virus antibodies in hospital personnel. | we have used a recently developed enzyme immunoassay to evaluate the prevalence of hepatitis c virus antibodies (anti-hcv) in patient groups and hospital personnel. the prevalence of anti-hcv in haemophiliacs, intravenous drug users, male homosexuals, and haemodialysis patients was 86, 63, 28, and 9 percent, respectively. eight of 738 (1.1 percent) sera from health care workers were positive for anti-hcv. only two of the 8 employees which were seropositive for anti-hcv also demonstrated serologi ... | 1991 | 1650558 |
| hepatitis c among risk groups for hiv and hepatitis b. | in order to obtain more information on sexual transmission of hepatitis c (hcv) we compared different high-risk groups for hiv and hepatitis b to see if they were seropositive for hcv. a high seroprevalence (38/81) of hepatitis c (hcv) was found among intravenous drug users. nursing staff (n = 35) and patients of a dialysis unit (n = 57) had a low prevalence of anti-hcv antibodies (0% and 5%, respectively). serology laboratory technicians also had a very low prevalence (0% out of 29). among pros ... | 1991 | 1650587 |
| hepatitis c antibody in patients with chronic liver disease and hepatocellular carcinoma. | hepatitis c virus (hcv) is the major etiologic agent of parenterally transmitted non-a, non-b hepatitis. to determine whether there is a relationship between this virus agent and hepatocellular carcinoma (hcc), the sera of patients with hcc and chronic hepatitis were assessed using a sensitive immunoassay for hcv antibody. anti-hcv was detected in 65% of 132 patients with hcc, without any relationship with the presence of the hepatitis b surface antigen (hbsag). the prevalence (74%) of anti-hcv ... | 1991 | 1650689 |
| prevalence of antibodies to hepatitis c virus in blood donors and risk groups in istanbul, turkey. | 1991 | 1650697 | |
| [early detection of anti-hvc using a second-generation test and usefulness of alt determination]. | 1991 | 1650965 | |
| lichen planus and hepatitis c virus. | 1991 | 1651354 | |
| high rate of infectivity and liver disease in blood donors with antibodies to hepatitis c virus. | to determine the epidemiologic, clinical, serologic, and histologic importance of antibodies to hepatitis c virus (anti-hcv) in blood donors. | 1991 | 1651674 |
| role of hepatitis c virus in non-b chronic liver disease. | to assess the contribution of the recently identified hepatitis c virus to chronic liver diseases of unknown cause and chronic hepatitis attributed by exclusion to non-a, non-b hepatitis, we tested for antibody to hepatitis c in hepatitis b surface antigen-negative patients with a spectrum of chronic liver diseases. antibody to hepatitis c virus, a marker of hepatitis c infection, was detected with a first-generation radioimmunoassay at the following frequencies in the following patient groups: ... | 1991 | 1651689 |
| hepatitis c antibody assay in a longitudinal study of haemophiliacs. | stored sera from 28 patients with inherited coagulation disorders who had developed non-a non-b hepatitis (nanbh) following a first exposure to clotting factor concentrates and 15 similar, but unmatched, patients who had received blood products but had normal transaminases on sequential testing were tested using the ortho enzyme-linked immunosorbent assay (elisa) anti-hcv assay. twenty-seven of the 28 patients with nanbh were anti-hcv positive after exposure. in 10 of those in whom dates of firs ... | 1991 | 1651756 |
| a serological study of hepatitis c infection in plasmapheresis donors. | an epidemic of parenterally transmitted non-a, non-b hepatitis (pt-nanbh) occurred in plasmapheresis donors in guan county, hebei province, china, in 1985. pt-nanbh was diagnosed by epidemiological studies and serological exclusion of hav, hbv, cmv and ebv infections. recently, 163 sera samples of 108 patients with pt-nanbh and 65 sera samples of 49 cases with elevated alanine aminotransferase (alt) levels collected during the epidemic were tested by anti-hcv eia (chiron c100). the positive rate ... | 1991 | 1651830 |
| [clinical and consequence study on 51 cases of hepatitis c]. | all the 51 patients had history of plasma donation before onset of the illness. all had no evidences of recent infection with following viruses: hav, hbv, cmv and ebv and were confirmed recently as hepatitis c by the chiron c-100 eia test. the incubation period was 35 to 90 days, with an average of 57.9 +/- 19.8 days. the ratio of icteric to anicteric was 1.0:1.55. only a few cases had fever in the acute phase (13.7%). 36 cases showed acute onset of illness; 15 cases, however, had alt elevation ... | 1991 | 1651836 |
| high incidence of antibodies to hepatitis c virus in alcoholic cirrhosis: fact or fiction? | an enzyme immunoassay (ortho-hcv elisa) for antibodies against the hepatitis c virus was used to test serum samples from 39 patients with alcoholic cirrhosis and 34 patients with alcoholic hepatitis or fatty liver. the frequency of a positive result in the cirrhotics was significantly higher than in the alcoholics without cirrhosis (38.5% vs 8.8%, p less than 0.01). however, the positive results in the cirrhotics were associated with high gammaglobulin concentrations, and optical density values ... | 1991 | 1652249 |
| [hepatitis c]. | 1991 | 1652297 | |
| hepatitis c virus (hcv) antibodies in the rheumatic diseases. | 1991 | 1652389 | |
| [symposium: current evaluation of diagnostic methods on viral hepatitis type c and consequent clinical features]. | in this symposium, the speakers have discussed the progress of the current diagnostic methods available for the diagnosis of viral hepatitis type c, and the accuracy and reproducibility at hand now, or which should be attained in the near future. since the first appearance of elisa (ortho) and ria (dainabot) kit, the screening of infected blood with hcv from donors has been very successful. posttransfusion hepatitis following infected blood transfusion has clearly decreased. the carrier rate of ... | 1991 | 1652658 |
| [hcv antibody test methods and patterns of antibody response]. | the sensitivity and specificity of the second generation elisa (2nd elisa) and riba (2nd riba) using c 22 and c 200 or c 33 c recombinant antigens encoded in the core and ns 3 of hcv genome have been evaluated preclinically by ortho and chiron (usa). sensitivity of the assay was evaluated by determining the reactivity of 2nd elisa and riba in the following panels: nanbh (n = 35) and high risk groups composed of: hemophiliacs (n = 50), ivda (n = 50) and renal dialysis cases (n = 279). in the reac ... | 1991 | 1652659 |
| antibody to hepatitis c is common among patients with alcoholic liver disease with and without risk factors. | thirty-seven patients with clinically suspected alcoholic liver disease were retrospectively studied for the prevalence of antibody to hepatitis c virus (hcv) by enzyme-linked immunosorbent assay (elisa) and immunoblot assay. twenty-four had biopsy-proven cirrhosis. nineteen had identifiable risk factors for non-a, non-b viral hepatitis, and 18 did not. five of 19 high-risk (26%) and 6 of 18 low-risk (33%) patients had positive antibody, compared with two of 179 healthy blood donors (p less than ... | 1991 | 1652885 |
| epidemiology of hepatitis c virus infection in a suburban detroit community. | a serum analysis for antibodies to the hepatitis c virus (hcv) was performed on a group of patients in a large suburban detroit community hospital. the first 50 anti-hcv-positive patients with clinically suspected chronic non-a, non-b hepatitis were studied. blood transfusions (58%) and intravenous drug use (22%) were the source of infection in most of these patients. a significant difference in age-related epidemiology was observed (p = 0.001). a remote history of intravenous drug use or tattoo ... | 1991 | 1652886 |
| detection of hepatitis c viral rna in serum of a patient with acute non a, non b hepatitis. | the sequence of serologic events in a patient with acute type c hepatitis associated with intravenous drug abuse is described. hepatitis c virus (hcv) ribonucleic acid was detectable in serum during the acute episode of hepatitis, whereas antibody to the hepatitis c virus appeared later, after the acute illness had subsided. the patient developed chronic hepatitis with persistently elevated serum aminotransferase activities. both hepatitis c viral ribonucleic acid and antibody to hepatitis c vir ... | 1991 | 1652887 |
| hepatitis c virus infection and chronic liver disease in children with leukemia in long-term remission. | antibody to the recently identified hepatitis c virus (hcv) was investigated in sera of 50 leukemic children who had chronic liver disease (cld), observed for 1 to 12.6 years after therapy withdrawal. all patients were tested for anti-hcv at regular intervals: ortho-enzyme-linked immunosorbent assay (elisa) test was performed in all cases. reactive sera were also tested by recombinant immunoblotting assay to define the specificity of the results obtained by elisa. twelve cases (24%) were persist ... | 1991 | 1653063 |
| long-term status of antibody to hepatitis c virus and the relation to the outcome of hepatitis: a retrospective study using stored sera from patients with sashima epidemic hepatitis. | 1991 | 1653161 | |
| evaluation of the kcl-163 elisa test for detecting antibodies against hepatitis c virus in patients with non-a, non-b chronic hepatitis. | a specific elisa test (kcl-163) for detecting anti-hepatitis c virus antibody (anti-hcv) has been developed (kaketsuken). using the kcl-163, 183 serum samples obtained from patients with non-a, non-b hepatitis (nanbh) were examined. we also tested and compared results with ortho hcv elisa (c100) and c825 elisa. of these 183 samples, 139 (76%), 121 (66%), and 88 (48%) were positive with kcl-163, c100 and c825, respectively. these results showed that there were patients with nanbh caused by hcv wh ... | 1991 | 1653162 |
| detection of antibodies to hepatitis c virus (anti-hcv) in patients with various liver diseases, by an elisa (kcl-163) test consisting of synthetic peptides corresponding to an hcv genome. | in 1989, the chiron group developed an enzyme immunoassay system (c100) for detecting antibodies to hepatitis c virus (anti-hcv). in our examinations, the positive rate was 65.3% of the total number of patients (199) with non-a, non-b (nanb) liver disease. additionally, a specific elisa system (kcl-163) was developed by kaketsuken (kumamoto, japan) based on synthetic peptides corresponding to an hcv genome of a japanese isolate. in this study, we measured antibodies to hcv by kcl-163, and compar ... | 1991 | 1653163 |
| interferon therapy for non-a, non-b chronic hepatitis. | we report the results of our study on 8-week consecutive interferon (ifn) treatment for chronic non-a, non-b hepatitis. in the 6 miu/day group, most cases had continuously normalized alanine-aminotransferase (alt) levels even after ifn treatment was discontinued. in responders whose alt levels remained normal, not only the degree of inflammation, as seen from hai scores, but also liver histopathological features were improved. moreover, antibody to hepatitis c virus (anti-hcv) titer in responder ... | 1991 | 1653164 |
| activity of antibodies to hepatitis c virus of patients with chronic non-a, non-b hepatitis decreases during interferon alpha therapy. | the activity of antibodies to hepatitis c virus (anti-hcv) was investigated in 80 patients with chronic non-a, non-b liver diseases. anti-hcv antibodies were positive in 82.5% (66/80), and the titers were 1 for 18 patients, 2 for 40 and 3 for 8, respectively. the frequency of anti-hcv was significantly lower in patients with chronic persistent hepatitis (8/13, 61.5%) than in those with chronic active hepatitis (42/49, 85.7%) (p less than 0.05). there was no significant difference in the distribu ... | 1991 | 1653165 |
| detection of replicative intermediates of hepatitis c viral rna in liver and serum of patients with chronic hepatitis c. | the hepatitis c virus is a positive stranded hepatotropic rna virus. we describe a method of detecting positive and negative strands of hepatitis c viral rna using the polymerase chain reaction. we tested serum and liver tissue from nine patients with chronic hepatitis c. the positive rna strand of hcv was detected in the sera and livers of all nine, the negative strand was detected in the livers of eight (89%), and in the sera of five (55%). titers of both strands of hcv rna were determined by ... | 1991 | 1653272 |
| hepatitis c virus antibody in hepatocellular carcinoma in taiwan. | the prevalence of antibody to hepatitis c virus (anti-hcv) was investigated in patients with hepatocellular carcinoma (hcc), and correlated with the clinical features. anti-hcv was detected in 129 histology or aspiration cytology proven hcc patients and 54 healthy controls. anti-hcv was examined by the hcv eia (abbott laboratories). all healthy controls were anti-hcv-negative. nineteen of 81 (23.5%) hepatitis b surface antigen (hbsag)-positive hcc patients were positive for anti-hcv. anti-hcv wa ... | 1991 | 1653308 |
| comparative molecular biology of the hepatitis viruses. | 1991 | 1653457 | |
| non-a, non-b hepatitis: toward the discovery of hepatitis c and e viruses. | 1991 | 1653458 | |
| blood-borne non-a, non-b hepatitis: hepatitis c. | 1991 | 1653459 | |
| [new possibilities in the diagnosis of viral hepatitis c]. | 1991 | 1653504 | |
| hepatitis c virus: evidence for sexual transmission. | 1991 | 1653631 | |
| hepatitis c virus antibodies in acute icteric and chronic non-a, non-b hepatitis. | hepatitis c virus antibodies were measured in 213 patients who had acute (n = 122) and chronic (n = 91) non-a, non-b hepatitis. in acute infection, anti-hepatitis c virus was detected in 61% of iv drug abusers, in 33% of patients with transfusion-associated hepatitis, and in 22% of patients with sporadic infections (p less than 0.0005, drug abusers vs. sporadic). mean time to seroconversion was 11.6 weeks (range, 1-80 weeks). anti-hepatitis c virus was more common in chronic infection (p less th ... | 1991 | 1653749 |
| characterization of nucleotide sequences from european hepatitis c virus isolates. | we characterized the 5' end and parts of the structural genes of european isolates of hepatitis c virus (hcv) and compared them with recently published rna sequences of american and japanese hcv isolates. the cdna, obtained by reverse transcription of viral rna extracted from different sera, was amplified by nested pcr, cloned and sequenced. within 239 nucleotides (nt) of the 5' end, we found only three single-nt exchanges compared to two sequences of japanese origin and one exchange to the prot ... | 1991 | 1653756 |
| chronic fatigue syndrome: lack of association with hepatitis c virus infection. | chronic fatigue syndrome (cfs) is a debilitating heterogeneous disorder lacking consistent, objective physical or laboratory abnormalities. among the hypothetical etiologies for cfs are chronic viral infections. the present controlled seroprevalence study found that, among typical cfs patients, evidence of hepatitis c virus (hcv) infection is uncommon. only one of 36 patients and none of 14 controls were anti-hcv positive. the positive patient had persistent aminotransferase elevations and prior ... | 1991 | 1653818 |
| antibodies to hepatitis c virus in autologous blood donors. | hepatitis c virus (hcv) is the major cause of posttransfusion hepatitis. two anti-hcv enzyme immunoassay (eia) kits and one recombinant immunoblot assay (riba) were used to test serum samples of 1476 donations from 692 autologous blood donors to assess the prevalence of anti-hcv and its relationship to transfusion history. of all autologous blood donations, 23 (1.6%) reacted when tested with one eia kit and 29 (2.0%) reacted when tested by the other eia kit. of the autologous donors, 12 (1.78%) ... | 1991 | 1654002 |
| descartes before the horse: i clone, therefore i am: the hepatitis c virus in current perspective. | in an unprecedented approach to viral discovery, the hepatitis c virus (hcv) was cloned before it was established by conventional methods of viral detection or by genomic characterization. hepatitis c virus is a small (10-kb), single-stranded rna virus with a genomic organization that places it in the family flaviviridae. the virus is global in distribution, with a prevalence between 0.3% and 1.5%. the same agent causes parenterally acquired and sporadic non-a, non-b hepatitis. nonparenteral mod ... | 1991 | 1654040 |
| randomized, double-blind, placebo-controlled trial of eight-week course of recombinant alpha-interferon for chronic non-a, non-b hepatitis. | forty-nine japanese patients were enrolled in a randomized, placebo-controlled, double-blind trial of alpha-interferon for chronic non-a, non-b hepatitis: 24 patients received 3 million units of recombinant human alpha alpha-interferon (alpha-2a) thrice weekly for eight weeks, and 25 patients received placebo in a similar schedule. the mean serum alanine aminotransferase (alt) dropped from 155 +/- 91 (sd) to 69 +/- 72 during interferon treatment, but remained unchanged (158 +/- 140 to 147 +/- 13 ... | 1991 | 1654240 |
| prevalence of antihepatitis c antibodies in patients treated with continuous ambulatory peritoneal dialysis and hemodialysis. | 1991 | 1654529 | |
| [practical approach to the discovery of a positive hcv serology in a blood donor]. | 1991 | 1654911 | |
| viruses and bone marrow failure. | many agents are associated with bone marrow failure, including toxins, inherited metabolic defects, ionizing radiation, and viral infection. in most cases, the etiologic agent is unknown. many of these unclassified cases have symptomatic, immunologic, or epidemiologic similarities to viral infections. viruses from different taxonomic families have been implicated in bone marrow failure syndromes, and they appear to cause hematosuppression by a variety of mechanisms. some of the viruses involved ... | 1991 | 1655129 |
| testing for hepatitis c virus. | 1991 | 1655135 | |
| association between hepatitis c virus antibodies and hepatocellular carcinoma in taiwan. | in order to assess the association between antibodies to hepatitis c virus (anti-hcv) and hepatocellular carcinoma (hcc), as well as the interaction of anti-hcv with other hcc risk factors in taiwan, a total of 127 pairs of newly diagnosed hcc patients and healthy community controls were studied. case-control pairs were individually matched for age (+/- 3 years), sex, residence, and ethnicity. serum samples from study subjects were examined for anti-hcv by enzyme immunoassays as well as hepatiti ... | 1991 | 1655259 |
| [high incidence of sporadic non-a, non-b hepatitis in morocco: epidemiologic study]. | non-a, non-b hepatitis and their sequelae seem to be as frequent as hbv infections in morocco. these diseases represent an important problem of public health because their high incidence and high fatal rate. some aspects of the epidemiology of non-a, non b acute hepatitis were evoking a high incidence of enterically transmitted hepatitis e. that was confirmed by serum studies having shown that hepatitis e antibodies were detected in more than 60% of patients with acute non-a, non-b hepatitis. ho ... | 1991 | 1655298 |
| the emerging picture of hepatitis c. | 1991 | 1655316 | |
| intrafamilial transmission of hepatitis c. | to identify intrafamilial transmission of hepatitis c virus, we tested for antibodies to hepatitis c virus (anti-hcv) in serum samples of 160 family members (12 parents, 17 siblings, 73 children, and 58 spouses) of 76 index patients with chronic hepatitis c. anti-hcv was detected in 14 of 160 family members (8.75%). this positive rate was significantly higher than the anti-hcv-positive rate in age-matched volunteer blood donors in our district (8.75% vs. 1.42%; p less than 0.01). among 14 member ... | 1991 | 1655552 |
| hepatitis c virus updated. | 1991 | 1655592 | |
| antibodies to hepatitis b virus and hepatitis c virus in alcoholic hepatitis and cirrhosis: their prevalence and clinical relevance. the va cooperative study group (no. 119) | patients with overt alcoholic liver disease who had participated in a multicenter therapeutic trial and subgroups of controls (i.e., alcoholic patients without liver disease and patients with neither alcoholism nor liver disease) were tested for hepatitis b virus and hepatitis c virus antibodies to determine the prevalence of these antibodies to determine the prevalence of these antibodies and any clinical association in the progression and outcome of alcoholic liver disease. antibodies to hepat ... | 1991 | 1655605 |
| use of conserved sequences from hepatitis c virus for the detection of viral rna in infected sera by polymerase chain reaction. | three oligonucleotide primer combinations selected from the 5' noncoding, the nucleocapsid and the putative nonstructural regions of the hepatitis c virus genome were compared in a nested polymerase chain reaction assay with respect to sensitivity and specificity for the detection of viral rna in chimpanzee-infected and human-infected sera. sera from both the acute and the chronic phase of the infection were obtained from 13 animals inoculated with five different non-a, non-b hepatitis strains a ... | 1991 | 1655606 |
| hepatitis b and c virus and alcohol-induced liver injury. | 1991 | 1655608 | |
| epidemiologic assessment of interactions of hepatitis-c virus with seromarkers of hepatitis-b and -d viruses, cirrhosis and tobacco smoking in hepatocellular carcinoma. | a recently introduced enzyme immunoassay procedure for antibodies against the hepatitis-c virus (hcv) was used to test samples from 185 cases with hepatocellular carcinoma (hcc) and 432 hospital controls. the anti-hcv results were examined in conjunction with previously reported data from this study concerning hepatitis-b virus (hbv) serology, hepatitis-d virus (hdv) antibodies, presence of cirrhosis and tobacco smoking. there was evidence for interaction between hbv and hcv in the causation of ... | 1991 | 1655659 |
| hepatitis c virus: an overview. | in may 1988, kuo and houghton and their colleagues in chiron research laboratory, in cooperation with the physicians from nih and cdc, announced their discovery of the agent which is responsible for the majority of non-a non-b hepatitis (nanb) in post-transfusion hepatitis (pth)1,2, concluding a 15-year effort to search for this elusive agent. although it is believed that there is another blood-borne agent responsible for a smaller percentage of the post-transfusion hepatitides, the new agent (a ... | 1991 | 1655677 |
| testing of blood donors for antibody to hcv: the hawaii experience. | 1991 | 1655678 | |
| hepatitis c virus-related chronic liver disease with autoantibodies to liver-kidney microsomes (lkm). clinical characterization from idiopathic lkm-positive disorders. | this study was carried out on 33 patients who were sero-positive for liver-kidney microsomal antibodies (lkm) in order to examine clinical features and the presence of underlying hepatitis c virus infection. twenty-four sera were positive for antibodies against hcv (anti-hcv) as detected by enzyme immunoassay and confirmed by recombinant immunoblot assay. these patients had chronic liver disease and the majority of those treated with interferon responded favourably. three of the nine anti-hcv-ne ... | 1991 | 1655868 |
| a prospective study of posttransfusion hepatitis in taiwan. | in a follow-up study of 6 months or more of two hundred and ninety-six patients who had received blood transfusion, 37 (12.5%) developed acute posttransfusion hepatitis. patients with posttransfusion hepatitis had significantly higher donor numbers and transfusion amounts than patients without hepatitis. frequency was not related to the age, sex or hepatitis b carriage of recipients. there were no cases of fulminant hepatitis. of 37 patients with hepatitis, 36 were diagnosed as non-a, non-b hepa ... | 1991 | 1655869 |
| partial nucleotide sequence analysis of a french hepatitis c virus: implications for hcv genetic variability in the e2/ns1 protein. | to contribute to the study of the genetic variability of hepatitis c virus (hcv) we have determined the nucleotide sequence of the e2/ns1 and ns3/ns4 regions of a french isolate using the polymerase chain reaction. comparison of these nucleotide sequences with those available for american and japanese isolates showed a significant genetic variability: 5 to 33% and 2 to 30% at the nucleic acid and amino acid levels, respectively. the genetic variability is higher in the e2/ns1 (13 to 33% and 12 t ... | 1991 | 1655961 |
| recombinant immunoblot assay for hepatitis c antibody in patients with posttransfusion non-a, non-b hepatitis. | in a prospective study of 287 patients who received blood transfusion, 26 who were found positive for hepatitis c antibody (anti-hcv) by an enzyme-linked immunosorbent assay (elisa) were studied by a recombinant immunoblot assay (riba). nineteen of the 26 patients had posttransfusion non-a, non-b (nanb) hepatitis. sixteen (84.2%) of the 19 patients with hepatitis had positive results by riba, 2 had indeterminate results, and 1 was negative. by contrast, five of the 7 recipients without hepatitis ... | 1991 | 1655967 |
| hepatitis c virus: buoyant density of the factor viii-derived isolate in sucrose. | physicochemical and molecular characterization studies of hepatitis c virus (hcv), the major causative agent of parenterally transmitted non-a, non-b hepatitis (pt-nanbh), strongly suggest that it is a pesti-/flavivirus-like virus. additional studies show that the buoyant density of plasma-derived hcv in sucrose is significantly lower than that of most tissue culture-derived flaviviruses (1.20 g/cm3). our finding suggests, but does not prove, that at least one physicochemical property of hcv is ... | 1991 | 1655970 |
| [detection of hepatitis c virus rna in serum during treatment of chronic hepatitis c with interferon alpha]. | we estimated hcv rna in serum of 20 patients with chronic hepatitis c during interferon therapy using a combination assay of reverse transcription and polymerase chain reaction (rt-pcr). rna was extracted from 200 microliters of serum. the primers were chosen from the ns3 region of prototype hcv rna sequence. after 40 cycles of pcr, the products were analyzed by southern hybridization. hcv rna was detected in 18 of 20 (90%) patients before therapy. in cases with improvement of serum gpt level, h ... | 1991 | 1656118 |
| detection of hepatitis c virus sequences in liver tissue by the polymerase chain reaction. | although sensitive assays for serum antibodies to hepatitis c virus (hcv/anti-hcv) have been developed recently, the relation of anti-hcv to hcv infection of the liver has not been clarified. therefore, we determined the presence of hcv rna by the reverse transcription-polymerase chain reaction (pcr) in liver biopsy specimens of 21 patients with chronic liver disease and 5 control patients. rna was extracted from frozen liver tissues by the guanidinium method, hcv cdna was synthesized by reverse ... | 1991 | 1656140 |
| hepatitis c virus infection in post-transfusion hepatitis. an analysis with first- and second-generation assays. | the causes of post-transfusion non-a, non-b hepatitis are still not fully defined, nor is it clear how accurate the tests are that are used to screen blood donors for hepatitis c virus (hcv) and to diagnose post-transfusion hepatitis caused by infected blood. | 1991 | 1656258 |
| maternal transfer of hcv. | 1991 | 1656274 | |
| [viral hepatitis c]. | 1991 | 1656507 | |
| association between hepatitis c virus and mixed cryoglobulinemia. | 1991 | 1656512 |