Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| chief medical officer's report on the nation's health: concerted action is needed to fight obesity, says chief medical officer. | 0 | 12855501 | |
| academic affairs. | 0 | 21765759 | |
| scanning the literature. | 0 | 21765767 | |
| west nile epidemic in louisiana in 2002. | in 2002, 329 cases of west nile illness were reported in louisiana, including 204 cases of west nile meningoencephalitis and 125 cases of west nile fever. clinical presentation of meningoencephalitis or of west nile fever was confirmed serologically. there were 24 deaths. age group distribution showed predominance among persons aged 45 years or older. the epidemic curve, based on date of diagnosis, showed numerous foci progressing in successive waves. the first cases occurred in mid-june. a peak ... | 0 | 21765763 |
| strengthening the btwc. the role of biological and toxin weapons convention in combating natural and deliberate disease outbreaks. | 0 | 12789410 | |
| the need to look outward. | 0 | 12839238 | |
| phlebovirus infection in greece: a case report. | sandfly-transmitted phleboviruses cause to humans an asymptomatic or mild infection to severe meningitis or encephalitis. phleovirus infections are common in the mediterranean countries during the summertime when sandflies are active. it is estimated that several cases remain undiagnosed. | 0 | 27418773 |
| west nile update - preparing for summer 2004. | 0 | 18159487 | |
| canadian doctors welcome public health initiatives in wake of sars. | 0 | 15070618 | |
| paul gauguin (1848-1903). i raro te oviri (under the pandanus) (1891). | 0 | 15212005 | |
| what are the chances? evaluating risk and benefit information in consumer health materials. | much consumer health information addresses issues of disease risk or treatment risks and benefits, addressing questions such as "how effective is this treatment?" or "what is the likelihood that this test will give a false positive result?" insofar as it addresses outcome likelihood, this information is essentially quantitative in nature, which is of critical importance, because quantitative information tends to be difficult to understand and therefore inaccessible to consumers. information prof ... | 0 | 15098049 |
| transfusion and risk of infection in canada: update 2004. | 0 | 19654994 | |
| transfusion and risk of infection in canada: update 2004. | 0 | 18159480 | |
| a sars commentary. | 0 | 18159446 | |
| the challenge of an increasingly expensive blood system. | 0 | 12719320 | |
| converging issues in veterinary and public health. | 0 | 12702239 | |
| one country, 13 immunization programs. | 0 | 12615765 | |
| transfusion and risk of infection in canada. | 0 | 20020007 | |
| transfusion and risk of infection in canada. | 0 | 18159428 | |
| fear of terrorism in new york after the september 11 terrorist attacks: implications for emergency mental health and preparedness. | to examine the public's response to future terrorist attacks, we surveyed 1,001 new yorkers in the community one year after the september 11 attacks. overall, new yorkers were very concerned about future terrorist attacks and also concerned about attacks involving biological or nuclear weapons. in addition, while most new yorkers reported that if a biological or nuclear attack occurred they would evaluate available information before evacuating, a significant number reported they would immediate ... | 0 | 14730761 |
| facts and ideas from anywhere. | 0 | 16278729 | |
| diversions. super-cef. | 0 | 12473628 | |
| facts and ideas from anywhere. | 0 | 16333479 | |
| new and emerging diseases--the wildlife interface. | 0 | 12395768 | |
| why "government, politics, and law"? | 0 | 12144969 | |
| interferon-λ restricts west nile virus neuroinvasion by tightening the blood-brain barrier. | although interferon-λ [also known as type iii interferon or interleukin-28 (il-28)/il-29] restricts infection by several viruses, its inhibitory mechanism has remained uncertain. we used recombinant interferon-λ and mice lacking the interferon-λ receptor (ifnlr1) to evaluate the effect of interferon-λ on infection with west nile virus, an encephalitic flavivirus. cell culture studies in mouse keratinocytes and dendritic cells showed no direct antiviral effect of exogenous interferon-λ, even thou ... | 0 | 25904743 |
| preliminary analysis of several attractants and spatial repellents for the mosquito, aedes albopictus using an olfactometer. | mosquito attractants and spatial repellents hold great promise in controlling mosquito pests. in assessing the effectiveness of mosquito attractants and repellents, a good olfactometer system, and optimized testing conditions, are essential. in this research, we demonstrated the usefulness of an olfactometer system, and optimized testing conditions for aedes albopictus (diptera: culicidae). we found no significant difference in the biting activity of the insect between 8:00 and 22:00. furthermor ... | 0 | 23418948 |
| medical risk factors for severe west nile virus disease, united states, 2008-2010. | we conducted enhanced surveillance to identify medical risk factors for severe illness (i.e., hospitalization or death) and neuroinvasive disease (i.e., encephalitis or meningitis) among all west nile virus disease cases reported from selected states from 2008 to 2010. of the 1,090 case-patients included in the analysis, 708 (65%) case-patients were hospitalized, 641 (59%) case-patients had neuroinvasive disease, and 55 (5%) case-patients died. chronic renal disease (adjusted odds ratio [aor] = ... | 0 | 22764311 |
| enhanced humoral and hla-a2-restricted dengue virus-specific t-cell responses in humanized blt nsg mice. | dengue is a mosquito-borne viral disease of humans, and animal models that recapitulate human immune responses or dengue pathogenesis are needed to understand the pathogenesis of the disease. we recently described an animal model for dengue virus (denv) infection using humanized nod-scid il2rγ(null) mice (nsg) engrafted with cord blood haematopoietic stem cells. we sought to further improve this model by co-transplantation of human fetal thymus and liver tissues into nsg (blt-nsg) mice. enhanced ... | 0 | 22384859 |
| a message from the editor. | 0 | 22753975 | |
| ecophysiology of avian migration in the face of current global hazards. | long-distance migratory birds are often considered extreme athletes, possessing a range of traits that approach the physiological limits of vertebrate design. in addition, their movements must be carefully timed to ensure that they obtain resources of sufficient quantity and quality to satisfy their high-energy needs. migratory birds may therefore be particularly vulnerable to global change processes that are projected to alter the quality and quantity of resource availability. because long-dist ... | 0 | 22566678 |
| toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection. | tlr7 is an innate signaling receptor that recognizes single-stranded viral rna and is activated by viruses that cause persistent infections. we show that tlr7 signaling dictates either clearance or establishment of life-long chronic infection by lymphocytic choriomeningitis virus (lcmv) cl 13 but does not affect clearance of the acute lcmv armstrong 53b strain. tlr7(-/-) mice infected with lcmv cl 13 remained viremic throughout life from defects in the adaptive antiviral immune response-notably, ... | 0 | 22704624 |
| spatial variation in host feeding patterns of culex tarsalis and the culex pipiens complex (diptera: culicidae) in california. | west nile virus (family flaviviridae, genus flavivirus, wnv) is now endemic in california across a variety of ecological regions that support a wide diversity of potential avian and mammalian host species. because different avian hosts have varying competence for wnv, determining the blood-feeding patterns of culex (diptera: culicidae) vectors is a key component in understanding the maintenance and amplification of the virus as well as tangential transmission to humans and horses. we investigate ... | 0 | 22897051 |
| a naturally occurring mutation within the probe-binding region compromises a molecular-based west nile virus surveillance assay for mosquito pools (diptera: culicidae). | a naturally occurring mutation was detected within the probe binding region targeting the envelope gene sequence of west nile virus used in real-time polymerase chain reaction assays to test mosquito pools and other samples. a single c-->t transition 6nt from the 5' end of the 16mer in the envelope gene probe-binding region at genomic position 1,194 reduced assay sensitivity. the mutation first was detected in 2009 and persisted at a low prevalence into 2011. the mutation caused a 0.4% false neg ... | 0 | 22897055 |
| regulatory t cells and th17 cells in viral infections: implications for multiple sclerosis and myocarditis. | in immune-mediated diseases, treg and proinflammatory th17 cells have been suggested to play either suppressor (beneficial) or effector (detrimental) roles, respectively. tissue damage in viral infections can be caused by direct viral replication or immunopathology. viral replication can be enhanced by anti-inflammatory responses and suppressed by proinflammatory responses. however, tregs could suppress proinflammatory responses, reducing immunopathology, while th17 cell-induced inflammation may ... | 0 | 23024699 |
| a retrospective study of spinal cord lesions in goats submitted to 3 veterinary diagnostic laboratories. | a retrospective study of spinal cord lesions in goats was conducted to identify the range of lesions and diseases recognized and to make recommendations regarding the best tissues to examine and tests to conduct in order to maximize the likelihood of arriving at a definitive etiologic diagnosis in goats with clinical signs referable to the spinal cord. twenty-seven goats with a spinal cord lesion were identified. the most common lesion recognized, in 13 of 27 goats, was degenerative myelopathy. ... | 0 | 23204583 |
| effects of blood meal source on the reproduction of culex pipiens quinquefasciatus (diptera: culicidae). | culex pipiens quinquefasciatus were fed blood meals from a live chicken (lc), chicken blood in alsever's (ac) solution, defibrinated bovine blood (db), or bovine blood in citrate (cb) and incubated at 28° c. the effects of different blood meal sources were evaluated with respect to rates of blood feeding and reproduction (i.e., fecundity and fertility) over two gonotrophic cycles. mosquitoes that fed on the first blood meal were subjected to a second blood meal as follows (first blood meal / sec ... | 0 | 22548531 |
| analysis of post-blood meal flight distances in mosquitoes utilizing zoo animal blood meals. | we assessed the post-blood meal flight distance of four mosquito species in a unique environment using blood meal analysis. mosquitoes were trapped at the rio grande zoo in albuquerque, nm, and the blood source of blood-engorged mosquitoes was identified. the distance from the enclosure of the animal serving as a blood source to the trap site was then determined. we found that mosquitoes captured at the zoo flew no more than 170 m with an average distance of 106.7 m after taking a blood meal. th ... | 0 | 22548540 |
| dengue encephalitis in children. | 0 | 22865995 | |
| plant extracts as potential mosquito larvicides. | mosquitoes act as a vector for most of the life threatening diseases like malaria, yellow fever, dengue fever, chikungunya ferver, filariasis, encephalitis, west nile virus infection, etc. under the integrated mosquito management (imm), emphasis was given on the application of alternative strategies in mosquito control. the continuous application of synthetic insecticides causes development of resistance in vector species, biological magnification of toxic substances through the food chain and a ... | 0 | 22771587 |
| lymphocytic choriomeningitis virus-associated meningitis, southern spain. | lymphocytic choriomeningitis virus (lcmv) was detected in 2 patients with acute meningitis in southern spain within a 3-year period. although the prevalence of lcmv infection was low (2 [1.3%] of 159 meningitis patients), it represents 2.9% of all pathogens detected. lcmv is a noteworthy agent of neurologic illness in immunocompetent persons. | 0 | 22515986 |
| serologic evidence of west nile virus infection among humans, morocco. | 0 | 22516366 | |
| autoimmune stiff person syndrome and related myelopathies: understanding of electrophysiological and immunological processes. | stiff person syndrome (sps) is a disabling autoimmune central nervous system disorder characterized by progressive muscle rigidity and gait impairment with superimposed painful spasms that involve axial and limb musculature, triggered by heightened sensitivity to external stimuli. impaired synaptic gabaergic inhibition resulting from intrathecal b-cell-mediated clonal synthesis of autoantibodies against various presynaptic and synaptic proteins in the inhibitory neurons of the brain and spinal c ... | 0 | 22499087 |
| modifiable risk factors for west nile virus infection during an outbreak--arizona, 2010. | west nile virus (wnv) is the leading cause of mosquito-borne disease in the united states; however, risk factors for infection are poorly defined. we performed a case-control study to identify modifiable risk factors for wnv infection. case-patients (n = 49) had laboratory evidence of recent wnv infection, whereas control-subjects (n = 74) had negative wnv serology. we interviewed participants, surveyed households, and assessed environmental data. wnv infection was associated with living in or n ... | 0 | 22556093 |
| effects of temperature on emergence and seasonality of west nile virus in california. | temperature has played a critical role in the spatiotemporal dynamics of west nile virus transmission throughout california from its introduction in 2003 through establishment by 2009. we compared two novel mechanistic measures of transmission risk, the temperature-dependent ratio of virus extrinsic incubation period to the mosquito gonotrophic period (bt), and the fundamental reproductive ratio (r(0)) based on a mathematical model, to analyze spatiotemporal patterns of receptivity to viral ampl ... | 0 | 22556092 |
| geographical information systems for dengue surveillance. | this review provides details on the role of geographical information systems (gis) in current dengue surveillance systems and focuses on the application of open access gis technology to emphasize its importance in developing countries, where the dengue burden is greatest. it also advocates for increased international collaboration in transboundary disease surveillance to confront the emerging global challenge of dengue. | 0 | 22556070 |
| diversity of wolbachia pipientis strain wpip in a genetically admixtured, above-ground culex pipiens (diptera: culicidae) population: association with form molestus ancestry and host selection patterns. | analysis of molecular genetic diversity in nine marker regions of five genes within the bacteriophage wo genomic region revealed high diversity of the wolbachia pipentis strain wpip in a population of culex pipiens l. sampled in metropolitan chicago, il. from 166 blood fed females, 50 distinct genetic profiles of wpip were identified. rarefaction analysis suggested a maximum of 110 profiles out of a possible 512 predicted by combinations of the nine markers. a rank-abundance curve showed that fe ... | 0 | 22679853 |
| role of gb virus c in modulating hiv disease. | gb virus c (gbv-c) is a member of the flaviviridae family and the most closely related human virus to hcv. however, gbv-c does not replicate in hepatocytes, but rather in lymphocytes. gbv-c has a worldwide distribution and is transmitted sexually, parenterally and through mother-to-child transmission. thus, co-infection with hcv and hiv is common. until now, no human disease has been associated with gbv-c infection. however, there are several reports of a beneficial effect of gbv-c on hiv diseas ... | 0 | 22702320 |
| the jak-stat pathway at twenty. | we look back on the discoveries that the tyrosine kinases tyk2 and jak1 and the transcription factors stat1, stat2, and irf9 are required for the cellular response to type i interferons. this initial description of the jak-stat pathway led quickly to additional discoveries that type ii interferons and many other cytokines signal through similar mechanisms. this well-understood pathway now serves as a paradigm showing how information from protein-protein contacts at the cell surface can be convey ... | 0 | 22520844 |
| generic statements require little evidence for acceptance but have powerful implications. | generic statements (e.g., "birds lay eggs") express generalizations about categories. in this paper, we hypothesized that there is a paradoxical asymmetry at the core of generic meaning, such that these sentences have extremely strong implications but require little evidence to be judged true. four experiments confirmed the hypothesized asymmetry: participants interpreted novel generics such as "lorches have purple feathers" as referring to nearly all lorches, but they judged the same novel gene ... | 0 | 21116475 |
| experiences of the student epidemic intelligence society in strengthening public health response and epidemiologic capacity. | 0 | 21121239 | |
| outbreak investigation partnerships: utilizing a student response team in public health responses. | 0 | 21121238 | |
| the nucleolus under stress. | cells typically respond quickly to stress, altering their metabolism to compensate. in mammalian cells, stress signaling usually leads to either cell-cycle arrest or apoptosis, depending on the severity of the insult and the ability of the cell to recover. stress also often leads to reorganization of nuclear architecture, reflecting the simultaneous inhibition of major nuclear pathways (e.g., replication and transcription) and activation of specific stress responses (e.g., dna repair). in this r ... | 0 | 20965417 |
| differential west nile fever ascertainment in the united states: a multilevel analysis. | we evaluated the completeness of west nile fever (wnf) surveillance within the u.s. public health system. we surveyed laboratory and surveillance programs on policies, practices, and capacities for testing, confirmation, and reporting (collectively called ascertainment) from 2003 through 2005. we calculated syndrome ascertainment ratios by dividing wnf counts by neuroinvasive disease counts; separately, we performed multilevel modeling. jurisdictions were more likely to ascertain at least one wn ... | 0 | 20889867 |
| human parvovirus b19 and blood product safety: a tale of twenty years of improvements. | 0 | 25849894 | |
| west nile virus infection incidence based on donated blood samples and neuroinvasive disease reports, northern texas, usa, 2012. | during the 2012 outbreak of west nile virus in the united states, approximately one third of the cases were in texas. of those, about half occurred in northern texas. models based on infected blood donors and persons with neuroinvasive disease showed, respectively, that ≈0.72% and 1.98% of persons in northern texas became infected. | 0 | 25812045 |
| human antibodies fix complement to inhibit plasmodium falciparum invasion of erythrocytes and are associated with protection against malaria. | antibodies play major roles in immunity to malaria; however, a limited understanding of mechanisms mediating protection is a major barrier to vaccine development. we have demonstrated that acquired human anti-malarial antibodies promote complement deposition on the merozoite to mediate inhibition of erythrocyte invasion through c1q fixation and activation of the classical complement pathway. antibody-mediated complement-dependent (ab-c') inhibition was the predominant invasion-inhibitory activit ... | 0 | 25786180 |
| future viral vectors for the delivery of asymptomatic herpes epitope-based immunotherapeutic vaccines. | 0 | 21442030 | |
| nonbacterial myositis. | infectious myositis is defined as an infection of a skeletal muscle. infectious myositis is most commonly caused by bacteria; however, a variety of viral, parasitic, and fungal agents may also cause myositis. the pathogenesis of nonbacterial infectious myositis is via direct or hematogenous infection of the musculature or immune mechanisms. symptoms typically include muscular pain, tenderness, swelling, and/or weakness. the diagnosis of the specific microbe is often suggested by the presence of ... | 0 | 21308520 |
| the effect of ageing on macrophage toll-like receptor-mediated responses in the fight against pathogens. | the cellular changes during ageing are incompletely understood yet immune system dysfunction is implicated in the age-related decline in health. the acquired immune system shows a functional decline in ability to respond to new pathogens whereas serum levels of cytokines are elevated with age. despite these age-associated increases in circulating cytokines, the function of aged macrophages is decreased. pathogen-associated molecular pattern receptors such as toll-like receptors (tlrs) are vital ... | 0 | 20646005 |
| the 'one health' paradigm: time for infectious diseases clinicians to take note? | 0 | 21886646 | |
| emerging and re-emerging animal viruses. foreword. | 0 | 21188838 | |
| vector-host interactions in avian nests: do mosquitoes prefer nestlings over adults? | the hypothesis that nestlings are a significant driver of arbovirus transmission and amplification is based upon findings that suggest nestlings are highly susceptible to being fed upon by vector mosquitoes and to viral infection and replication. several previous studies have suggested that nestlings are preferentially fed upon relative to adults in the nest, and other studies have reported a preference for adults over nestlings. we directly tested the feeding preference of nestling and adult bi ... | 0 | 20682889 |
| modeling health impacts of the transportation built environment: challenges and opportunities. | 0 | 25796702 | |
| methods for detection of west nile virus antibodies in mosquito blood meals. | we describe and compare 2 qualitative serologic techniques for detecting west nile virus (wnv)-specific antibodies in mosquito blood meals. the techniques are the biotin microsphere immunoassay (b-mia) and the inhibition platform of the vectortest™ wnv antigen assay (vectest-inhibition). to demonstrate the ability of these tests to detect wnv-neutralizing antibodies, we experimentally exposed feeding mosquitoes to blood containing 5 concentrations of 6b6c-1, a flavivirus-neutralizing monoclonal ... | 0 | 25843170 |
| ebola virus: the need to take some preventive measures. | 0 | 26101517 | |
| risky bodies in the plasma bioeconomy: a feminist analysis. | in 2003 the uk national blood service introduced a policy of 'male donor preference' which involved women's plasma being discarded following blood collection. the policy was based on the view that data relating to the incidence of transfusion-related acute lung injury (trali) was linked to transfusion with women's plasma. while appearing to treat female donors as equal to male donors, exclusion criteria operate after donation at the stage of processing blood, thus perpetuating myths of universal ... | 0 | 26097401 |
| r0 for vector-borne diseases: impact of the assumption for the duration of the extrinsic incubation period. | mathematical modeling and notably the basic reproduction number r0 have become popular tools for the description of vector-borne disease dynamics. we compare two widely used methods to calculate the probability of a vector to survive the extrinsic incubation period. the two methods are based on different assumptions for the duration of the extrinsic incubation period; one method assumes a fixed period and the other method assumes a fixed daily rate of becoming infectious. we conclude that the ou ... | 0 | 25793478 |
| high seroprevelance of west nile virus antibodies observed in horses from southwestern nigeria. | to investigate exposure of nigerian horses to west nile virus (wnv), we determined the seroprevalence rate of anti-wnv antibody in a cohort of 145 horses. serum samples were collected from three locations in southwestern nigeria between october, 2011, and july, 2012. the horses were asymptomatic and unvaccinated against wnv at the time of sampling. all sera were tested using a competition enzyme-linked immmunosorbent assay (elisa) and by an immunoglobulin m (igm)-specific elisa. high rates of an ... | 0 | 25793479 |
| rhabdomyolysis: pathogenesis, diagnosis, and treatment. | rhabdomyolysis is a complex medical condition involving the rapid dissolution of damaged or injured skeletal muscle. | 0 | 25829882 |
| treatment of ebola virus infection with antibodies from reconvalescent donors. | clinical evidence suggests that antibodies from reconvalescent donors (persons who have recovered from infection) may be effective in the treatment of ebola virus infection. administration of this treatment to ebola virus-infected patients while preventing the transmission of other pathogenic viruses may be best accomplished by use of virus-inactivated reconvalescent plasma. | 0 | 25695274 |
| distinct plasma immune signatures in me/cfs are present early in the course of illness. | myalgic encephalomyelitis/chronic fatigue syndrome (me/cfs) is an unexplained incapacitating illness that may affect up to 4 million people in the united states alone. there are no validated laboratory tests for diagnosis or management despite global efforts to find biomarkers of disease. we considered the possibility that inability to identify such biomarkers reflected variations in diagnostic criteria and laboratory methods as well as the timing of sample collection during the course of the il ... | 0 | 26079000 |
| rapid analysis of pharmacology for infectious diseases. | pandemic, epidemic and endemic infectious diseases are united by a common problem: how do we rapidly and cost-effectively identify potential pharmacological interventions to treat infections? given the large number of emerging and neglected infectious diseases and the fact that they disproportionately afflict the poorest members of the global society, new ways of thinking are required to developed high productivity discovery systems that can be applied to a larger number of pathogens. the growin ... | 0 | 21401504 |
| canadian federal support for climate change and health research compared with the risks posed. | for emerging public health risks such as climate change, the canadian federal government has a mandate to provide information and resources to protect citizens' health. research is a key component of this mandate and is essential if canada is to moderate the health effects of a changing climate. we assessed whether federal support for climate change and health research is consistent with the risks posed. we audited projects receiving federal support between 1999 and 2009, representing an investm ... | 0 | 21490335 |
| new academic partnerships in global health: innovations at mount sinai school of medicine. | global health has become an increasingly important focus of education, research, and clinical service in north american universities and academic health centers. today there are at least 49 academically based global health programs in the united states and canada, as compared with only one in 1999. a new academic society, the consortium of universities for global health, was established in 2008 and has grown significantly. this sharp expansion reflects convergence of 3 factors: (1) rapidly growi ... | 0 | 21598272 |
| systems biology in immunology: a computational modeling perspective. | systems biology is an emerging discipline that combines high-content, multiplexed measurements with informatic and computational modeling methods to better understand biological function at various scales. here we present a detailed review of the methods used to create computational models and to conduct simulations of immune function. we provide descriptions of the key data-gathering techniques employed to generate the quantitative and qualitative data required for such modeling and simulation ... | 0 | 21219182 |
| potential targets for pancreatic cancer immunotherapeutics. | pancreatic adenocarcinoma is the fourth leading cause of cancer death with an overall 5-year survival of less than 5%. as there is ample evidence that pancreatic adenocarcinomas elicit antitumor immune responses, identification of pancreatic cancer-associated antigens has spurred the development of vaccination-based strategies for treatment. while promising results have been observed in animal tumor models, most clinical studies have found only limited success. as most trials were performed in p ... | 0 | 21463193 |
| preparing a people: climate change and public health. | 0 | 21459696 | |
| semen banking: consideration on viral contamination in the era of new emerging viral infection. | 0 | 25587263 | |
| how evolutionary principles improve the understanding of human health and disease. | an appreciation of the fundamental principles of evolutionary biology provides new insights into major diseases and enables an integrated understanding of human biology and medicine. however, there is a lack of awareness of their importance amongst physicians, medical researchers, and educators, all of whom tend to focus on the mechanistic (proximate) basis for disease, excluding consideration of evolutionary (ultimate) reasons. the key principles of evolutionary medicine are that selection acts ... | 0 | 25567971 |
| estimating disease prevalence using inverse binomial pooled testing. | monitoring populations of hosts as well as insect vectors is an important part of agricultural and public health risk assessment. in applications where pathogen prevalence is likely low, it is common to test pools of subjects for the presence of infection, rather than to test subjects individually. this technique is known as pooled (group) testing. in this paper, we revisit the problem of estimating the population prevalence p from pooled testing, but we consider applications where inverse binom ... | 0 | 21743789 |
| structure and mechanisms of sf1 dna helicases. | superfamily i is a large and diverse group of monomeric and dimeric helicases defined by a set of conserved sequence motifs. members of this class are involved in essential processes in both dna and rna metabolism in all organisms. in addition to conserved amino acid sequences, they also share a common structure containing two reca-like motifs involved in atp binding and hydrolysis and nucleic acid binding and unwinding. unwinding is facilitated by a "pin" structure which serves to split the inc ... | 0 | 23161005 |
| population dynamics of blood-fed female mosquitoes and comparative efficacy of resting boxes in collecting them from the northwestern part of riverside county, california. | testing of blood-fed mosquitoes plays an integral role in arbovirus surveillance and in understanding its interaction mechanisms between host, vector and reservoir. the present study was undertaken to evaluate the efficacy of two different traps (gravid and resting boxes) for collection of blood-fed mosquitoes in the northwestern part of riverside county. | 0 | 23599612 |
| t-cell-mediated immunity and the role of trail in sepsis-induced immunosuppression. | sepsis is the leading cause of death in most intensive care units, and the death of septic patients usually does not result from the initial septic event but rather from subsequent nosocomial infections. patients who survive severe sepsis often display severely compromised immune function. not only is there significant apoptosis of lymphoid and myeloid cells that depletes critical components of the immune system during sepsis, there is also decreased function of the remaining immune cells. studi ... | 0 | 23510024 |
| west nile virus infection among humans, texas, usa, 2002-2011. | we conducted an epidemiologic analysis to document west nile virus infections among humans in texas, usa, during 2002-2011. west nile virus has become endemic to texas; the number of reported cases increased every 3 years. risk for infection was greatest in rural northwestern texas, where culex tarsalis mosquitoes are the predominant mosquito species. | 0 | 23260575 |
| aedes (stegomyia) aegypti and aedes (howardina) cozumelensis in yucatán state, méxico, with a summary of published collection records for ae. cozumelensis. | we collected mosquito immatures from artificial containers during 2010-2011 from 26 communities, ranging in size from small rural communities to large urban centers, located in different parts of yucatán state in southeastern méxico. the arbovirus vector aedes (stegomyia) aegypti was collected from all 26 examined communities, and nine of the communities also yielded another container-inhabiting aedes mosquito: aedes (howardina) cozumelensis. the communities from which ae. cozumelensis were coll ... | 0 | 23181861 |
| prediction and prevention of the next pandemic zoonosis. | most pandemics--eg, hiv/aids, severe acute respiratory syndrome, pandemic influenza--originate in animals, are caused by viruses, and are driven to emerge by ecological, behavioural, or socioeconomic changes. despite their substantial effects on global public health and growing understanding of the process by which they emerge, no pandemic has been predicted before infecting human beings. we review what is known about the pathogens that emerge, the hosts that they originate in, and the factors t ... | 0 | 23200504 |
| anatomy of a pandemic. | 0 | 23200486 | |
| no evidence of prolonged hendra virus shedding by 2 patients, australia. | to better understand the natural history of hendra virus infection and its tendency to relapse, 2 humans infected with this virus were monitored after acute infection. virus was not detected in blood samples when patients were followed-up at 2 and 6 years. thus, no evidence was found for prolonged virus shedding. | 0 | 23171522 |
| transfusion and risk of infection in canada: update 2012. | although multiple critical steps are taken to minimize the risk of infection from transfusion of blood or blood products in developed countries, this risk can never be entirely eliminated. in canada, the risks of noninfectious transfusion reactions, such as transfusion-related acute lung injury and major allergic or anaphylactic reactions, are greater than that of infection. this updated practice point provides an overview of transfusion infection risks in canada. infectious agents, systemic con ... | 0 | 24294070 |
| meningitis with a negative cerebrospinal fluid gram stain in adults: risk classification for an adverse clinical outcome. | to derive and validate a risk score for an adverse clinical outcome in adults with meningitis and a negative cerebrospinal fluid (csf) gram stain. | 0 | 23218086 |
| 18-year-old woman with fever, abdominal pain, and elevated liver enzymes. | 0 | 23218092 | |
| optical coherence tomography (oct): imaging the visual pathway as a model for neurodegeneration. | axonal and neuronal degeneration are important features of multiple sclerosis (ms) and other neurologic disorders that affect the anterior visual pathway. optical coherence tomography (oct) is a non-invasive technique that allows imaging of the retinal nerve fiber layer (rnfl), a structure which is principally composed of ganglion cell axons that form the optic nerves, chiasm, and optic tracts. since retinal axons are nonmyelinated until they penetrate the lamina cribrosa, the rnfl is an ideal s ... | 0 | 21274691 |
| a case of paraneoplastic limbic encephalitis associated with ovarian teratoma and n-methyl-d-aspartate receptor antibodies. | 0 | 22295267 | |
| translational research: forging a new cultural identity. | 0 | 18828172 | |
| viral vigilance. new surveillance strategies and methods help to identify dangerous pathogens earlier: a prerequisite for efficient countermeasures. | 0 | 18830223 | |
| viral immunity: it takes two to tango. | viral infections were a major cause of mortality until the use of vaccination and antiviral drugs became widespread. during the last 10 years, immunologists have made tremendous progress in dissecting mechanisms that contribute to the success of vaccines, in understanding the molecular and cellular basis of innate immunity, and in recognizing the complexity of immunological memory. virologists have also made great progress in elucidating the molecular mechanisms of how viruses evade, manipulate, ... | 0 | 18681801 |
| disaster mythology and fact: hurricane katrina and social attachment. | misconceptions about disasters and their social and health consequences remain prevalent despite considerable research evidence to the contrary. eight such myths and their factual counterparts were reviewed in a classic report on the public health impact of disasters by claude de ville de goyet entitled, the role of who in disaster management: relief, rehabilitation, and reconstruction (geneva, world health organization, 1991), and two additional myths and facts were added by pan american health ... | 0 | 18828410 |
| immunoaffinity capillary electrophoresis as a powerful strategy for the quantification of low-abundance biomarkers, drugs, and metabolites in biological matrices. | in the last few years, there has been a greater appreciation by the scientific community of how separation science has contributed to the advancement of biomedical research. despite past contributions in facilitating several biomedical breakthroughs, separation sciences still urgently need the development of improved methods for the separation and detection of biological and chemical substances. in particular, the challenging task of quantifying small molecules and biomolecules, found in low abu ... | 0 | 18646282 |
| in search of a better mosquito repellent. | 0 | 18709154 |