Publications

nucleotide accumulations in escherichia coli infected with some bacteriophage t4 amber mutants.		1968	4302002
transcription during bacteriophage t4 development: requirements for late messenger synthesis.		1968	4302631
comparison of a t4 resin sponge uptake method with a protein-bound iodine procedure.		1968	4175133
enzymatic synthesis of deoxyribonucleic acid. xxv. purification and properties of deoxyribonucleic acid polymerase induced by infection with phage t4.		1968	4866523
host-controlled restriction of t-even bacteriophages: relation of endonuclease i and t-even-induced nucleases to restriction.	restriction of nonglucosylated t2 phage (t(*)2) as a function of bacterial growth state was the same for endonuclease i-containing and endonuclease i-deficient strains of escherichia coli b. furthermore, e. coli strains with various levels of restriction for t2 had comparable endonuclease i activities. it was also found that a t4 mutant temperature-sensitive for gene 46 and 47 functions was fully restricted at 42 c. it therefore appears that neither endonuclease i nor the phage-induced nucleases ...	1968	4911845
bacteriophage-induced inhibition of host functions. i. degradation of escherichia coli deoxyribonucleic acid after t4 infection.	the kinetics of degradation of bacterial deoxyribonucleic acid (dna) after infection of escherichia coli with t4d, ultraviolet-irradiated t4d, and two amber mutants, n122 and n94, was studied by zone sedimentation through linear glycerol gradients. within 5 min after infection with any of the bacteriophages, breakdown of host genome was evident. the first product was a high-molecular-weight material (50s to 70s) and further degradation appeared to occur in discrete steps. rapid and extensive bre ...	1968	4911847
reversible repression of early enzyme synthesis in bacteriophage t4-infected escherichia coli.	a mutant of escherichia coli b, defective in its accumulation of k(+), was found to synthesize protein at a rate proportional to the level of this cation in the growth medium. when bacteriophage t4-infected cells were incubated in growth medium containing 1 mm k(+), phage deoxyribonucleic acid (dna) was synthesized at a rate 25% that of normal, and phage protein was synthesized at a rate of 50% of normal. deoxycytidine pyrophosphatase, a phage-directed early enzyme, shut off at a level of 55% th ...	1968	4911851
control of lysis of t4-infected escherichia coli.	the lysis of escherichia coli b/5 infected with t4dr48 could be delayed by addition of 9-aminoacridine (9aa). infected cells showed an early period of maximal response followed by a decline in sensitivity. the ultimate rate of lysis was also affected by the dye. deoxyribonucleic acid (dna), protein, and lysozyme synthesis began at the normal time in complexes inhibited by 9aa addition. the rates of synthesis of these macromolecules were lower in the presence of the dye, with dna and lysozyme syn ...	1968	4911852
molecular recombination in the ligase negative t4 amber mutant.		1968	4894254
intermediates in t4 dna replication in a t4 ligase deficient strain.		1968	4891959
studies on the joining of dna by polynucleotide ligase of phage t4.		1968	4891960
repair and recombination in phage t4. i. genes affecting recombination.		1968	4891972
repair and recombination in phage t4. ii. genes affecting uv sensitivity.		1968	4891973
the function of t4 dna polymerase.		1968	4891974
evidence for a possible direct role of dcmp hydroxymethylase in t4 phage dna synthesis.		1968	4891975
replication and recombination of dna fragments in bacteriophage t4.		1968	4891976
phage dna synthesis in bacteria infected with t4 light particles.		1968	4891977
dna polymerase and the cell membrane after t4 infection.		1968	4891988
initiation and propagation of growing points in the dna of phage t4.		1968	4891989
purification of bacteriophage t4 lysozyme.		1968	4865643
non-repeating nucleotide sequences in the genome of bacteriophage t4.		1968	4866115
polyriboadenylate polymerase and its inhibition in t4-infected escherichia coli and shigella dysenteriae.		1968	4866301
transcription during bacteriophage t4 development: synthesis and relative stability of early and late rna.		1968	4866329
bacterial genetic factors controlling the suppression of t4 phage amber mutants. i. suppression patterns of a collection of e. coli strains.		1968	4890344
bacterial genetic factors controlling the suppression of t4 phage amber mutants. ii. suppression patterns among the segregants of bacterial crosses.		1968	4890345
acridine binding by escherichia coli: ph dependency and strain differences.	acridine dye binding by cells of escherichia coli has been characterized in terms of a number of parameters. there is a temperature-dependent, readily reversible binding of acriflavine which occurs to a greater extent with acridine-sensitive mutants of e. coli k-12 than with wild-type e. coli b or k-12. there is an essentially irreversible internal binding of acriflavine which occurs when the cellular permeability barriers are destroyed or altered by heat-treatment, elevated ph, treatment with t ...	1968	4867737
location of glucosyl transferase genes on the genetic map of phage t4.		1968	4867911
assembly of the tail of bacteriophage t4.		1968	4868421
some steps in the assembly of bacteriophage t4.		1968	4868422
exhaustive hybridization and its application to an analysis of the ribonucleic acid synthesized in t4-infected cells.		1968	4868543
modified dna-dependent rna polymerase from e. coli infected with bacteriophage t4.		1968	4869542
specificity of polyribosomes in the synthesis of t4 bacteriophage head protein.		1968	4870334
fractionation of the complementary strands of coliphage t4 dna based on the asymmetric distribution of the poly u and poly u,g binding sites.		1968	4870391
studies on the morphopoiesis of the head of phage t-even. v. the components of the t4 capsid and of other, capsid-related structures.		1968	4870477
lysis of t4-infected bacteria in the absence of lysozyme.		1968	4871001
failure of incomplete t4 genomes to replicate under conditions of single infection.		1968	4871002
inhibition of gamma-ray-induced degradation of e. coli bs-1 dna by infection with t1, t2 and t4 bacteriophage.		1968	4871998
evidence for long dna strands in the replicating pool after t4 infection.		1968	4873341
genetic transformation of the bacteriophage t4. ii. biological activity of dna fragments.		1968	4873555
genetic transformation of the bacteriophage t4. i. an outline and some properties of the phage transformation system.		1968	4873560
nonsense suppression in a multiauxotrophic derivative of escherichia coli 15t-: identification and consequences of an amber triplet in the deoxyribomutase gene.	previously, arginine revertants of escherichia coli wwu, a derivative of e. coli 15t(-), have been subdivided by two independent methods: (i) the streak morphology on nutrient agar, and (ii) the pattern of phage growth using amber and ochre mutants of bacteriophage t4. in the first assay, revertants were subdivided into two classes according to the appearance of streaks after incubation on nutrient agar, a thick, even line of growth defining normal revertants and a thin, irregular line defining ...	1968	4874302
metabolism of deoxythymidine 3'-mono- and diphosphate in normal and t4 bacteriophage-infected escherichia coli.		1968	4875414
studies of dna replication in vivo. 3. accumulation of a single-stranded isolation product of dna replication by conditional mutant strains of t4.		1968	4875804
influence of t4 on the formation of rna phage-specific polyribosomes and polymerase.		1968	4877003
role of polynucleotide ligase in t4 dna replication.		1968	4877007
coding by t4 phage dna of soluble rna containing pseudouridylic acid.		1968	4877271
[t4 phage-induced lysozyme dependent e. coli treated with mytomycin c].		1968	4878093
[correlation between filament formation of e. coli and plaque-type changes of bacteriophage t4].		1968	4878095
enzymatic breakage and joining of deoxyribonucleic acid. vi. further purification and properties of polynucleotide ligase from escherichia coli infected with bacteriophage t4.		1968	4879167
control of phage and host ribonucleic acid synthesis in phage t4 infected escherichia coli.		1968	4879187
phospholipid synthesis in escherichia coli infected with t4 bacteriophages.	after infection of escherichia coli with t4 phage, phospholipid synthesis continued but at a reduced rate. the same phospholipid components were synthesized as in uninfected cells; however, the relative rates of (32)p(i) incorporation into phosphatidylglycerol (pg) and phosphatidylethanolamine (pe) were altered. this alteration was most pronounced during the first 10 min after infection. under these conditions, the isotope incorporated into pg equaled or exceeded that found in pg from uninfected ...	1968	4880428
effect of t4 infection on messenger rna synthesis in escherichia coli.		1968	4880561
transfer rna coded by the t4 bacteriophage genome.		1968	4880604
biochemistry of deoxyribonucleic acid-defective amber mutant of bacteriophage t4. i. ribonucleic acid metabolism.		1968	4880757
the role of phage lysozyme in the life cycle of phage t4.		1968	4881032
a structural gene for bacteriophage t4-induced deoxycytidine triphosphate-deoxyuridine triphosphage nucleotidohydrolase.		1968	4881036
mode of action of colicins of types e1, e2, e3, and k.	the effect of colicins on deoxyribonucleic acid and protein synthesis, and also their effect on the ability of t4 phage to replicate in escherichia coli k-12, were studied. colicins of type k inhibited deoxyribonucleic acid synthesis, protein synthesis, and phage growth. among colicins of type e, there was an absolute correlation between mode of action and subdivision into types e(1), e(2), and e(3).	1968	4882019
[polarity mutation of t4 phage].		1968	4882392
distribution of growing points in dna of bacteriophage t4.		1968	4882615
inhibition of host protein synthesis during infection of escherichia coli by bacteriophage t4. i. continued synthesis of host ribonucleic acid.	the ribonucleic acid (rna) synthesized at specified intervals during infection of escherichia coli k-12 by bacteriophage t4 was hybridized to denatured e. coli or t4 deoxyribonucleic acids (dna). the reactions were performed under conditions that maximized the yield and at rna/dna inputs such that excess dna sites were available for all rna species. most of the rna synthesized at any time during the first 3 min of infection was host-specific. the fraction declined rapidly as infection progressed ...	1968	4883015
further studies on the requirement for formyl residues in the synthesis of bacteriophage t4 proteins.		1968	4883326
studies on the lysozyme from the bacteriophage t4 ejd7ejd4, carrying two frame shift mutations.		1968	4883531
amino acid control of rna synthesis in t4-infected escherichia coli.		1968	4884582
recovery of uv-inactivated e. coli cells by the v-gene action of phage t4.		1968	4884675
enzymatic breakage and joining of deoxyribonucleic acid. iv. dna synthesis in e. coli infected with ligase-negative mutants of phage t4.		1968	4884682
evidence for a magnesium pump induced by bacteriophage t4.		1968	4972798
an in vitro transversion by a mutationally altered t4-induced dna polymerase.		1968	4939629
chain growth rate of messenger rna in escherichia coli infected with bacteriophage t4.		1968	4938556
identification of the transcribing dna strand for the rii and endolysin genes of coliphage t4.		1968	4938565
complete primary structure of phage lysozyme from escherichia coli t4.		1968	4939036
direction of translation of the lysozyme gene of bacteriophage t4 relative to the linkage map.		1968	5637201
indices during administration of t4 and t3 to euthyroid adults.		1968	5641753
genotypic reversion by methylene blue: the orientation of guanine-hydroxymethylcytosine at mutated sites in rii mutants of phage t4.		1968	5646389
the extent of rii deletions in phage t4.		1968	5647634
genetic transformation of the bacteriophage t4. 3.		1968	5661361
mutagenic treatment of double- and single-stranded dna phages t4 ans s13 with hydroxylamine.		1968	5663335
viscosity study of dna. ii. the effect of simple salt concentration on the viscosity of high molecular weight dna and application of viscometry to the study of dna isolated from t4 and t5 bacteriophage mutants.		1968	5663405
the mutagenic effect of hydroxyaminopurine derivatives on phage t4.		1968	5672975
the mechanism of inactivation of t4 bacteriophage by tritium decay.	coliphage t4 was used as a model system to study the mechanism of biological inactivation produced by tritium decay. experimentally, tritiated precursors were incorporated into phage dna (thymidine-(3)h) or into phage protein ((3)h-amino acids). the ratio of killing efficiencies for decays originating in phage dna to those originating in phage protein was 2.6. inactivation by decays from labeled amino acids was assumed to occur exclusively from beta-particle irradiation of phage dna. if decays o ...	1968	5678320
induction of mutation in phage t4 by extracellular treatment with methylene blue and visible light.		1968	5683001
the effect of ultraviolet light on the intracellular stability of the dna of bacteriophages t2 and t4.		1968	5683009
frame shift mutations near the beginning of the lysozyme gene of bacteriophage t4.	a pair of frame shift mutations in the lysozyme gene of bacteriophage t4 results in the substitution of a glutamyl-tyrosyl sequence for the asparagine residue that is the penultimate amino-terminal amino acid in the lysozyme of the wild-type strain. one of the mutations has been identified as the insertion of two bases, the other as the insertion of a single base.	1968	5686221
transfer of ultraviolet light induced thymine dimer from parental to progeny dna in bacteriophage t1 and t4.		1968	5696504
autonomous replication of short dna fragments in the ligase negative t4 am h39x.		1968	5697273
change of tryptophan residue at the 158th position of t4 bacteriophage lysozyme into a tyrosine residue by suppression and spontaneous reversion of an amber mutatnt.		1968	5700428
effect of prophage w on the propagation of bacteriophages t2 and t4.	studies have been undertaken to determine whether the temperate phage omega present in escherichia coli strain w is responsible for the inability of this strain to act as a host for t2 and t4. e. coli ws, cured of phage omega, was sensitive to t2 and t4. lysogenation of e. coli c and ws with phage omega resulted in loss of ability to plate t2 and t4. however, e. coli k-12 lysogens still served as hosts for the t -even phage. two of three ws lysogens studied resembled strain w at the biochemical ...	1968	5701827
a map of distances along the dna molecule of phage t4.		1968	5702346
the effect of helper phages and--or multiplicity of infection on the repair of ultraviolet damages in t4.		1968	5722186
inactivation of phage t4 by ethylmethane sulfonate.		1968	5722213
inactivating and mutagenic effects of 1-methyl-3-nitro-1-nitrosoguanidine on intracellular bacteriophage.	1-methyl-3-nitro-1-nitrosoguanidine (ng) was able to inactivate and mutate adsorbed but not free coliphage t2. coliphage t4 was as sensitive to ng as t2. when treatment was delayed for 5 min or longer after adsorption of t2, the phage became increasingly refractory to ng inactivation.	1968	5725321
t4 bacteriophage mutants suppressible by a missense suppressor which inserts glycine in place of arginine for the codon aga.	phage mutants of t4 have been isolated which can multiply only on escherichia coli strains which contain a missense suppressor which is known to cause the substitution of glycine for arginine in response to the aga codon. mutations producing the suppressible phenotype were mapped and shown to occur in six different phage cistrons. two of the cistrons were concerned with deoxyribonucleic acid synthesis, two were concerned with phage structural components, and two were concerned with functions req ...	1968	5725322
in vitro synthesis of t4 late messenger rna.		1968	5238977
dna replication in vivo by a temperature-sensitive polynucleotide ligase mutant of t4.		1968	5246564
antimutagenic dna polymerases of bacteriophage t4.		1968	5254574
dna replication after t4 infection.		1968	5254576
a biological assay for in vitro repair of phage t4 dna.		1968	5254577
amino acid acceptor activity of bacteriophage t4 transfer rna.		1968	11946263
the luria-latarjet effect studied by t4-lysozyme production.	the replication of bacteriophage t4 in escherichia coli is sensitive to ultraviolet light (uv). the classical plaque assay shows a considerable increase in uv resistance starting at about 5 minutes after the bacteria are infected. production of phage lysozyme starts about 10 minutes after infection and is sensitive to irradiation. its uv resistance increases at about 4 minutes. the appearance of resistance, measured by both the plaque assay and lysozyme production, is inhibited by p-fluorophenyl ...	1968	18614109
mechanism of bacteriophage t4 neutralization by rabbit immunoglobulin and its proteolytic digestion fragments.		1969	4185044
a semiautomated method which does not require digestion for the determination of serum thyroxine iodine (t4).		1969	4304015