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letter: zoster in three children in family. 19744370956
[facial paralysis of unknown origin. testing for a viral etiology by antibody measurement]. 19744371064
persistent infections with herpesviruses. 19744371164
[letter: varicella prevention in persons with impaired immunoapparatus]. 19744371630
serologic response to varicella-zoster membrane antigens measured by direct immunofluorescence. 19744372275
cytosine arabinoside for localized herpes zoster in patients with cancer: failure in a controlled trial. 19744372276
workshop on hospital-associated infections. 19744372277
acute lymphoblastic leukemia of childhood: results of combination therapy. 19744372664
evidence for chronic viral infections in human arteries. 19744373754
the role of viruses in congenital defects. 19744374081
varicella virus isolation from spinal ganglion. 19744374161
[letter: prevention against varicella and herpes zoster in individuals with impaired immunological defence]. 19744374773
letter: recurrent varicella-like illness in a child with leukaemia. 19744136064
[infection by varicella-zoster virus during pregnancy (author's transl)]. 19744136385
letter: increase of premalignant cervical lesions in teenagers. 19744138326
live vaccine used to prevent the spread of varicella in children in hospital. 19744139526
editorial: a chickenpox vaccine? 19744139533
cryocurettage in the treatment of corneal ulcers: additional observations. 19744152353
[use of the igm fraction from patients' sera in general virus serology for diagnostic purposes]. 19744154618
pneumonias acquired outside the hospital. recognition and treatment. 19744132588
bell's palsy in infants associated with varicella-zoster virus infection. 197412119924
virus infections in renal transplant recipients.534 serum samples from 73 renal transplant recipients, 41 haemodialysis patients, and 99 blood and organ donors were examined serologically for antibodies against cytomegalo, h. simplex (types 1 and 2), varicella-zoster, epstein-barr, adeno, influenza, parainfluenza, respiratory syncytial, measles, picorna- and human polyoma- viruses. serum specimens were stored in the lyophilized state until examined thus enabling a simultaneous testing of all samples belonging to one patient. all antigens, com ...1975126545
elevated immunofluorescence antibody titers to several herpesviruses in burkitt's lymphoma patients: are high titers unique?antibody titers for viral capsid antigens of all four human herpesviruses were measured by immunofluorescence in the sera of 16 burkitt's lymphoma (bl) patients, 16 age-, sex-, and locality-matched controls, and 136 family members from the west nile district of uganda. among family members, titers greater than 1:4 were found in 98% for herpes simplex virus (hsv), 86% for varicella-zoster virus (vzv), 100% for cytomegalovirus (cmv), and 94% for epstein-barr (ebv). titers in patients averaged appr ...1975163324
the densities of herpesviral dnas. 1975164053
partial characterization of a soluble antigen preparation from cells infected with human cytomegalovirus: properties of antisera prepared to the antigen.soluble antigen (sa) preparations were obtained from cell cultures infected with either the davis or ad169 strains of cytomegalovirus (cmv). fractionation of sa preparations through sephadex g-200 resulted in a molecular weight value ranging from 67,000 to 85,000. rate-zonal centrifugation produced an approximate value of 5.5s for the cmv antigenic material. antisera to sa prepared from either ad169- or davis-infected cells lacked neutralizing activity but produced specific fluorescence confined ...1975164507
the varicella-zoster virus in the etiology of severe congenital defects. a survey of eleven reported instances. 1975165028
treatment of varicella-zoster virus infections with adenine arabinoside.twenty-three patients with complicated varicella-zoster virus infections were treated with adenine arabinoside. of 14 patients with herpes zoster, 13 had malignancy treated with irradiation and cytotoxic agents or steroids. although the duration of active vesicle formation in these patients ranged from two to 14 days before therapy, no new lesions appeared after the fourth day of treatment with adenine arabinoside. zoster encephalitis developed in one patient on the third day of treatment, and s ...1975165242
cellular events in zoster vesicles: relation to clinical course and immune parameters.the cellular responses in zoster vesicles was studied chronologically in 30 patients, some of whom were compromised hosts with disseminated disease. cell counts were low initially but rose abuptly later. polymorphonuclear leukocytes predominated at all times in the vesicular fluid and in the cells adherent to the vesicle base. the abrupt rise in the number of cells generally coincided with an abrupt rise in the titer of vesicular interferon; both increases preceded resolution of local infection ...1975165243
[seroepidemiological study of varicella-zoster virus by complement fixation reaction]. 1975165248
ineffectiveness of subcutaneous cytosine arabinoside in localized herpes zoster.cytosine arabinoside (cytarabine) was evaluated in a randomized double-blind controlled study for the treatment of localized herpes zoster. cytarabine was administered subcutaneously in a dose of 50 mg/m-2 body surface area once daily for 4 days, always within 14 days of onset of the first symptom and usually within 7 days. thirty patients given cytarabine and 30 patients given placebo were well matched with respect to age, sex, and length and severity of presenting rash and pain as well as unde ...1975166586
inconspicuous viral pneumonitis: a potential relationship to evolving emphysema. 1975166602
varicella-zoster virus and subcutaneous cytarabine: correlation of in vitro sensitivities to blood levels.the susceptibility of 26 strains of varicella-zoster virus to cytarabine was tested in vitro by measuring reduction in number and size of plaques using human foreskin fibroblast cells. most strains showed 50% reduction of plaque number by 0.125 mug of cytarabine per ml or less. cytarabine levels in sera of 12 patients after a single subcutaneous injection of 50 mg/m(2) exceeded this inhibitory level for a period of 75 min. thus, the subcutaneous route is a potentially useful method of administra ...1975166610
effect of human leukocyte interferon on vaccinia-and herpes virus-infected cell cultures and monkey corneas.pretreatment of human fibroblast cultures with human leukocyte interferon (hif, 1,000 iu/ml) resulted in a 24-h delay of virus replication after infection with vaccinia virus and herpes simplex virus type 1 and type 2. additional hif treatment 24 h after infection effectively lowered the maximum yield of viral infectivity. equal results were obtained in simian cells with 3,000 iu of hif per ml. the spread of two cell-bound herpesviruses, varicella zoster virus and medical lake macaque herpesviru ...1975166924
herpes simplex virus in idiopathic facial paralysis (bell palsy).sera from all 41 adult patients with idiopathic facil paralysis (bell palsy) and 35 (85%) of 41 matched controls who had never had bell palsy contained antibodies to herpes simplex virus (p smaller than.05). the frequency of antibodies to herpes zoster virus did not differ in patients and controls. a rise in antibody titer, indicating primary herpes simplex virus infection, was not found in these patients. that bell palsy may be caused by reactivation of herpes simplex virus is suggested by (1) ...1975167209
investigations on the properties of established cell lines of human and animal origin to induce cartilage and bone and properties of human fibroblasts transformed by varicella virus. 1975167238
the ultrastructure of disrupted herpesvirus nucleocapsids. 1975167517
development of a live attenuated varicella vaccine.the oka strain of varicella virus, isolated in our labolatory, was serially cultivated in guinea-pig embryo cultures (gpec), and a considerable amount of cell-free virus was obtained from infected cell. gpec passage virus at the 6th passage level was used in a small scale field trial. susceptible children of 1 to 10 years old were injected subcutaneously with 100 to 1,000 pfu of virus. no clinical reactions due to the vaccination were observed in any children, and a high rate of antibody respons ...1975167707
application of a live attenuated varicella vaccine to hospitalized children and its protective effect on spread of varicella infection.twenty-three hospitalized children with no history of varicella or no detectable complement fixing (cf) antibody, were vaccinated with a live attenuated varicella vaccine (oka strain) immediately after the occurrence of a case of varicella in a children's ward of hospital. these children suffered from the nephrotic syndrome, nephritis, purulent meningitis, hepatitis etc., and 12 of them were receiving steroid therapy. an antibody response was noticed in all the vaccinated children, with mild fev ...1975167708
detection of viral cores having toroid structures in eight herpes viruses. 1975167709
immunological relationship between delta herpesvirus of patas monkeys and varicells-zoster virus of humans.the delta herpesvirus (dhv) which produced outbreaks of exanthematous disease in patas monkeys was shown to have a close immunological relationship to varicella-zoster (v-z) virus of man. immunization of rhesus monkeys with dhv or v-z virus resulted in the development of neutralizing antibodies to both viruses and also in the production of complement-fixing antibodies to v-z virus. immunoglobulin m neutralizing antibody to v-z virus was demonstrated in the serum of a rhesus monkey immunized with ...1975168152
[virus propagation, virus replication and virus elimination in the human skin in zoster].the purpose of this study was to investigate the spreading, the replication and the elimination of varicella-zoster-virus (zv) in human skin. typical skin lesions of thoracic zoster in different stages of development and of exanthematic vesicles in ophthalmic zoster were examined under the electron microscope. we found that zv may be detected in fully developed vesicular skin lesions only, whereas in immature lesions and in the surrounding non involved skin axonal alterations may be seen, with n ...1975168168
[letter: isolation of zoster patients]. 1975168169
letter: possbile relation between herpes simplex and zoster. 1975168491
antiviral activity of a pyrazino-pyrazine derivative.the 2,3-dihydroxy-6-bromo-pyrazino-[2,3-beta]-pyrazine is a substance selected during the antiviral screening of pyrazino-pyrazine derivatives. the compound shows antiviral activity in vitro against measles, ndv, some influenza viruses and against herpes simplex and zoster, infectious canine hepatitis and vaccinia viruses. it had no effect on echo 9 virus. therapeutic trials showed activity also on herpetic keratoconjunctivitis experimentally induced in rabbits.1975169110
varicella-zoster immunoglobulins during varicella, latency, and zoster.antibodies to membrane antigens of cells infected by varicella-zoster virus were detected by immunofluorescence. rises in varicella-zoster iga, igg, and tigm were detected after both varicella and zoster. prompt antibody responses were observed in patients with generalized zoster as well as in those with localized zoster. a delayed response was found, moreover, in one patient who did not develop disseminated disease. antibody to varicella-zoster virus was detected in the sera of all three patien ...1975169308
unusual infections of the nervous system in malignant lymphomas.infection of the nervous system by toxoplasma, cytomegalovirus and varicella-zoster virus is described in three adult patients with malignant lymphoma. morphologic identification of these organisms in otherwise nonspecific lesions is emphasized. since such intercurrent infections are not usually diagnosed clinically in debiliated patients, their recognition at autopsy is important, particularly in view of the wide spread distribution of these organisms in normal population.1975169666
clinical aspects of viral infections in kidney-graft recipients. 1975170042
neutralizing antibody responses to varicella-zoster virus.neutralization of varicella-zoster (v-z) virus by human sera and immune rhesus monkey sera was enhanced by fresh guinea pig complement. there was no marked difference in the degree to which complement enhanced neutralization by sera from current v-z virus infections and sera from long-past varicella infections. immunoglobulin g neutralizing antibody in sera from varicella cases was enhanced by complement to a slightly higher degree than was immunoglobulin m (igm) antibody, and immunoglobulin g n ...1975170206
vaccination against herpes group viruses. 1975170580
vaccination against herpesviruses. 1975170581
antibody titers by mixed agglutination to varicella-zoster, herpes simplex and vaccinia viruses in patients with multiple sclerosis.antibody titers to varicella-zoster (v-z), herpes simplex (hsv) and vaccinia viruses were determined in sera collected in buffalo, ny, from patients with multiple sclerosis (ms), patients with other diseases, and normal individuals. the mixed agglutination test employing cell cultures infected with one of the above viruses as a source of antigen was used to determine antibody titers. the geometric mean titer (gmt) for v-z in 59 ms cases was significantly higher than that observed in patients wit ...1975170625
epidemiology of cytomegalovirus infection after transplantation and immunosuppression.viral infections and clinical complications were studied during hemodialysis and after renal transplantation. active cytomegalovirus infection developed in 96% of patients after renal transplantation; reactivation of herpes simplex, varicella-zoster, and epstein-barr viruses was found in 35%, 24%, and 0% of patients, respectively. cytomegalovirus viremia developed in 42% of patients an average of two months after renal transplantation, lasted 1.75 (+/- 1.5) months (except in one patient with chr ...1975171315
should patients with zoster receive zoster immune globulin?zoster developed in 55 patients, and 15, generalized disease occurred. twelve of 14 patients with dissemination had prompt appearance of both complement-fixing (cf) antibody and fluorescent antibody against varicella-zoster (vs) membrane antigen (fama). the geometric mean titers of vz antibody from the first to the fifth and the sixth through the tenth days following onset of zoster were similar in patients with localized and generalized involvement. two patients with disseminated zoster had und ...1975171458
[letter: immunization against varicella (the priority of pál ferencz)]. 1975172830
seroepidemiologic survey of varicella: value of specific fluorescent antibody test.the sensitive varicella-zoster fluorescent antibody to membrane antigen (v-z fama) test was used in a seroepidemiologic survey of two outbreaks of varicella involving 30 children. the attack rate of varicella based on clinical observations alone was 60%. the attack rate based on clinical and serological observations lay between 78% and 82%, after excluding those children who had detectable antibody at the time of exposure. no subclinical varicella infection was observed in this small series of p ...1975172853
infection of guinea-pig embryo cells with varicella-zoster virus.varicella-zoster (vz) virus has been shown to replicate in guinea-pig embryo (gpe) cells. when cell-free virus inocula were used, no infectious virus was liberated from these cells, either by freezing-thawing or ultrasonic disruption. however, cell-free virus was separated from gpe cells inoculated with infected human embryonic lung (hel) cells.1975172949
pathology of the human spinal ganglia in varicella-zoster virus infection.spinal ganglia from a patient who died on the 6th day of varicella infection were examined by immunofluorescence and electron microscopy, and were compared with spinal ganglia from a patient dying on the 17th day of herpes zoster infection. in herpes zoster, typical intranuclear inclusion bodies were found in neurons, satellite cells and fibroblast-like cells of the ganglia, which contained numerous naked virus particles. in varicella, few changes were found by light microscopy but viral antigen ...1975173126
[study of herpes zoster keratitis; demonstration of virus particles in corneal scrapings (author's transl)]. 1975173166
in vitro antiherpetic activity of water-soluble amphotericin b methyl ester. 1975173265
idoxuridine ocular insert therapy. use in treatment of experimental herpes simplex keratitis.therapy of acute herpes simplex keratitis in rabbits with idoxuridine-releasing ocular inserts showed that an application rate of 30mug/hr gave significantly better results than conventional treatment with idoxuridine drops and ointment while exposing the eye to 40% less drug. delivery rates lower than this were equal or not as effective as drop and ointment therapy and rates up to 100 mug/hr did not produce significantly better results than rates of 30mug/hr. serial viral cultures demonstrated ...1975173270
[determination of anti-cytomegalovirus antibodies by the immunoperoxidase method: comparison with the methods of complement fixation and immunofluorescence].indirect immunoperoxidase technique (iip) has been employed for determination of igg antibody titer to cytomegalovirus (cmv) in sera from 110 blood donors. titers have been compared with complement fixation (cf) and indirect fluorescent antibody (ifa) technique titers, the latter being applied to determination of all specific antibody classes. within variability range of the quality of reagents employed in different tests, it seems reasonable to conclude iip technique is as sensitive as ifa and ...1975173374
[the immunoperoxidase technic in the rapid identification of human cytomegalovirus on primary isolation].immunoperoxidase technique has been applied to the rapid identification of human cytomegalovirus (cmv) strains on primary isolation. negative and positive results have been constantly confirmed by indirect fluorescent antibody technique (ifa) and by electron microscopy. using either direct or indirect method it was observed that problems of nonspecific staining of uninfected cells were encountered mostly with direct method, probably because of the lower working dilution of the conjugate (1:20) a ...1975173375
varicella-zoster ophthalmicus. 1975178619
letter: live varicella vaccine. 197546043
prophylaxis of varicella in children with neoplastic disease: comparative results with zoster immune plasma and gamma globulin.the incidence and severity of varicella following a close family contact were evaluated in children with neoplastic diseases who received prophylaxis either with commerical gamma globulin or with zoster immune plasma, as compared to patients who did not receive any prophylaxis. in the untreated group, all 14 patients developed varicella, complicated by 1 case of encephalitis and 2 cases of fatal pneumonia. in the group of 17 patients who received 0.6-1.2 ml/kg body weight of gamma globulin, 16 d ...197546775
letter: rapid diagnosis of virus infections. 197549678
a case of peripheral facial palsy following varicella. 197551052
the pathogenesis of simian varicella virus in cynomolgus monkeys.the mlm herpesvirus is infectious for cynomolgus monkeys. the disease in this species, possibly modulated by preinoculation antibody resembles human varicella. virus has been recovered from blood during the early incubation period, and from liver, lymph nodes, kidney, bladder and urine during the eruptive period of infection. the major target organs were skin and liver; specific pathological changes developed in both. appropriate antibody responses, including those to herpesvirus varicellae foll ...1975174129
the role of viral infection in acute peripheral facial palsy.thirty-three patients with acute non-traumatic peripheral facial palsy were studied. in one patient, varicella-zoster virus was isolated from csf. antibody against the same virus was present in csf, and rising titre was demonstrated in serum. in two cases, herpes virus hominis was isolated from the nasopharynx. cf-antibody tests indicated recent viral infection in 7 other cases. one additional patient had clinical signs of herpes zoster oticus. in most of these 11 patients, but also in the major ...19751136761
effects of adenine arabinoside on cellular immune mechanisms in humans.in vitro lymphocyte blastogenic responses to the commonly employed mitogens, phytohemagglutinin, pokeweed, and concanavalin a, were evaluated when adenine arabinoside (ara-a) in a concentration of 3 mug/ml was added to the culture materials. similarly, blastogenic and cytotoxic responses to cell cultures persistently infected with herpes simplex virus 1, herpes simplex virus 2, and varicella-zoster virus were determined in the presence of ara-a. no depression of these cellular immune responses b ...19751137371
isolation of varicellazoster virus from blood. 1976175145
herpes zoster--a parasitic fossil. 1976175355
in vitro susceptibility of varicella zoster virus to adenine arabinoside and hypoxanthine arabinoside.the in vitro susceptibility of varicella zoster (vz) isolates to adenine arabinoside (ara-a) and hypoxanthine arabinoside (ara-hx) was determined in human skin fibroblasts. using a system in which deamination was inhibited, and using a modified plaque reduction method, the antiviral activities of ara-a and ara-hx were separated. the plaque inhibitory concentration of ara-a for all vz isolates tested was 1 to 2 mug/ml and 80 to 100 mug/ml for ara-hx. a comparison of antiviral activity based upon ...1976176937
[immunologic status in hodgkin patients: correlation with epstein-barr virus titers].1. in hodgkin's disease patient's immunological in vitro and in vivo parameters are of prognostic importance. 2. skin test reactivity correlates to peripheral t-lymphocyte counts and con a induced lymphoblastogenesis. 3. con a is the most sensitive in vitro indicator for detecting latent immunodeficiency. 4. hodgkin patients in long term remission after tumor reductive therapy exhibit a qualitative and quantitative lymphocyte defect. 5. in hodgkin patients herpes virus related antibody titers ar ...1976177135
indirect haemagglutination reaction (lh)-the method of choice for the detection of anamnestic antibodies to varicella - zoster (vz) virus.the method of indirect haemagglutination is a sensitive quantitative serological reaction for the detection of anamnestic titres of vz antibodies. the curve obtained by the examination of a representative population sample has shown that the occurrence of vz antibodies increases with the age so that 60% of children of under-school age and 90% of 15-year-old children have antibodies to varicella-zoster virus. in adult age groups, seropositivity ranges between 90--100%. the incidence and level of ...1976177705
coxsackievirus and adenovirus infection. association with acute febrile and juvenile rheumatoid arthritis.the prearthritic manifestations of juvenile rheumatoid arthritis in a 16-year-old boy were associated with a rise in coxsackievirus b3 and a9 neutralizing antibody titers from 1:16 to larger than or equal to 1:512, and 1:64 to 1:512, respectively. recurrent polyarthritis followed and has persisted for three years. adenovirus 7 was isolated from the pericardial fluid of a 9-year-old girl in whom juvenile rheumatoid arthritis then developed. of 11 patients with acute, nonspecific, febrile arthriti ...1976177792
adenine arabinoside therapy of herpes zoster in the immunosuppressed. niaid collaborative antiviral study.we evaluated adenine arabinoside treatment of herpes zoster in immunodeficient patients in a randomized, controlled crossover study. the two study groups had similar characteristics. in spite of rapid natural healing, those receiving adenine arabinoside over the first five days had accelerated clearance of virus from vesicles (p = 0.01), and cessation of new vesicle formation (p = 0.004), and a shorter time to total pustulation (p = 0.001). factors modifying the response to therapy included age, ...1976177866
detection of antibody to varicella-zoster virus by immune adherence hemagglutination.a serologic test for measurement of antibody to v-z virus by immune adherence hemagglutination is described. initial evaluation of the test has shown it to be highly sensitive, specific, rapid, and simple to perform. the v-z antigen may be stored at -70 degrees, and the test could be performed in any routine serology laboratory.1976177988
early diagnosis of virus-caused vesicular rashes by immunofluorescence on skin biopsies. i. varicella, zoster and herpes simplex.the use of immunofluorescence (if) for the rapid identification of varicella-zoster (v-z) and herpes simplex (hs) antigen in frozen sections of biopsies of early non-vesicular skin lesions was investigated. direct if, using fluorescein- isothiocyanate- conjugated immuoglobulin (fitc ig) of paired human anti-v-z sera and fitc-conjugated negative and positive anti-v-z-monkey ig, yielded specific fluorescence of virus antigen in all 14 varicella cases investigated and in 10/11 zoster cases. in cont ...1976178050
a candidate vaccine for chickenpox. 1976190323
chickenpox vaccine. 1976190324
letter: contact infection from live varicella vaccine recipients. 197657366
meningitis associated with herpes zoster. immunofluorescent demonstration of varicella-zoster antigens in csf cells. 197661267
the demonstration of cell-associated immunity to viruses. in vitro lymphocyte responsiveness to varicella-zoster antigen.the demonstration of in vitro lymphocyte responsiveness to common pediatric viruses has previously been fraught with many technical and conceptual problems. based upon our prior experience in demonstrating cell-associated immunity to mumps, rubella and measles viruses we illustrate our methodology and conceptual framework by documenting in vitro lymphocyte responsiveness to the varicella-zoster virus, another ubiquitous virus of childhood. we discuss our approach to the problems of reactivity, s ...197662002
reactivation of varicella virus in trigeminal ganglion. 197663028
an immunofluorescence technique with counterstain on fixed cells for the detection of antibodies to human herpesviruses; antibody patterns in patients with hodgkin's disease and nasopharyngeal carcinoma.an indirect immunofluorescence (if) test on fixed cells with evans' blue counterstain is described for all four human herpesviruses, i.e., herpes simplex virus type 1 and type 2 (hsv-1 and hsv-2), varicella-zoster virus (vzv), cytomegalovirus (cmv) and epstein-barr virus (ebv). comparison with immunodiffusion (id) for hsv-2 and with id and complement fixation (cf) for vzv and cmv demonstrated the specificity and high sensitivity of the if test. also introduced is a modification of the anti-compl ...197667099
use of live varicella vaccine in children with acute leukaemia or other malignancies. 197673844
[complement fixation antibodies against varicella zoster virus in mexico city]. 1976194343
herpes zoster ophthalmicus.herpes zoster ophthalmicus is not an uncommon disease and is more prevalent among debilitated and seriously ill patients. it is caused by the same virus causing varicella. the exact trigger mechanism is unknown, as well as much of the pathogenesis. the disease is more uncommon among the elderly and usually runs a benign course. approximately 50% of the patients develop ocular complications ,the most frequent of these being keratitis, iritis, secondary glaucoma and extraocular muscle involvement. ...1976191772
varicella-zoster virus and facial palsy.two cases of ramsey-hunt syndrome are reported, one of which presented features of the guillain-barré syndrome. it is suggested that the varicella-zoster virus is an aetiological factor in the guillain-barré syndrome.1976178811
peripheral facial palsy and herpes zoster infection.a clinical and virological study of 133 consecutive cases of peripheral facial palsy has provided evidence for simultaneous infection with the varicella-zoster virus in 9 patients (6-8 per cent). seven of these presented differing but typical manifestations of the ramsay hunt syndrome, and the diagnosis was therefore strongly suspected on the basis of the clinical findings alone. the remaining two patients had neither herpetiform rash nor involvement of the eighth cranial nerve, and had been dia ...1976178812
acute facial palsy. some clinical and virological observations.a prospective clinical and virological study on 44 patients with acute, peripheral facial paralysis was carried out in consecutive cases during one year. in 9 cases varicella-zoster infections were serologically established. in 5 additional patients an associated varicella-zoster, or herpes simplex, infection was possible. of the 9 confirmed cases, 6 were clinically diagnosed as zoster oticus, whereas on clinical grounds, 3 were regarded as bell's palsy. no evidence was obtained of associated en ...1976179268
selection of cell culture systems for virus isolation.a survey of cell culture systems for virus isolation is presented. because there is not single cell culture system which will support the many viruses that may be encountered in clinical specimens, the characteristics and susceptibility of primary, diploid, and continuous cell cultures are reviewed. the primary cell culture system should be susceptible to infection with myxoviruses, paramyxoviruses, adenoviruses, and coxsackie b viruses, since these are not consistently recognized in diploid cel ...1976179319
diseases associated with herpesviruses.human herpesviruses have been associated with numerous diseases throughout history (table 3), but their ability to induce latent and recurrent infections, alongwith their oncogenic capabilities, is only beginning to be understood. accordingly, our ability to deal with the diseases induced by herpesviruses is severely limited by our lack of information concerning the basic processes of virus-host cell interactions and systemic host factors; especially immune factors that are involved in the disea ...1976179753
viral diseases of the skin, 1975: a 25-year perspective.most of the major advances in modern virology during the past 25 years have been due principally to the development of refined laboratory techniques and tools and have provided a fund of new knowledge and information about the nature of viral infection and pathogenesis. one group of viruses of interest to dermatologists, the herpesviruses, is undergoing intensive biochemical investigation to determine whether it is carcinogenic. as a result of the success of the world health organization's campa ...1976180187
adenine arabinoside for therapy of herpes zoster in immunosuppressed patients: preliminary results of a collaborative study.eighty-seven immunosuppressed patients (53 with localized and 34 with disseminated herpes zoster) from 10 institutions were enrolled in a controlled therapeutic trial of adenine arabinoside. a crossover design was employed; thus, 47 patients received drug for five days and then received placebo, and 40 were given the two substances in the opposite order. resolution of acute pain and the cutaneous lesions were graded during a 10-day observation period. during the initial five-day period, treated ...1976180198
varicella-zoster antibodies in adult patient with haemoblastoses.indirect haemagglutination (ih) antibodies to varicella-zoster (vz) virus were investigated, under the identical conditions of a single experiment, in a group of patients with haemoblastoses and 80 normal adults of equal age groups. statistical significance of the differences in vz antibody geometric mean titres between the individual haemoblastoses and normal controls was examined by means of variance analysis. a significantly raised mean titre was still found in the hodgkin's disease group.1976180728
necrotizing retinopathy with herpes zoster ophthalmicus: a light and electron microscopical study.a necrotizing retinopathy following a vesicular cutaneous eruption in the distribution of the right trigeminal nerve developed in a patient who had been receiving systemic corticosteroid therapy one week prior to the onset of herpes zoster ophthalmicus. seven weeks after the herpetic symptoms began, the patient died of pneumonia following an intracerebral hematoma. at postmortem examination, unexpected multiple focal and confluent lesions, which corresponded to areas of extensive retinal necrosi ...1976180930
severe hemorrhagic varicella with visceral involvement: virological and serological studies during treatment with cytosine arabinoside.a boy 13 year-old suffered an extremely severe and prolonged attack of hemorrhagic chickenpox with visceral involvement, the diagnosis being confirmed by isolation of varicella-zoster-virus (vzv). there was no other compromising disease. all preceding vaccinations including two against smallpox had been uneventful. the severity of the attack could not be ascribed to any persistent cellular or humoral immunodeficiency. the patient developed a good antibody response. the course of serological reac ...1976181329
anti-ebv antibody titers in non-hodgkin lymphomas.antibody titers to epstein-barr virus (ebv)-related antigens, i.e. viral capsid antigen (vca), the d and r components of the early antigen (ea) complex and the ebv-associated nuclear antigen (ebna), were determined in a series of 86 patients with non-hodgkin lymphomas and in 150 matched control subjects. the lymphoma patients belonged to four histological groups: diffuse, nodular, hyperbasophilic malignant lymphoma (hml) and unclassified. the ebv-related serological data were compared to the inc ...1976181335
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