Publications

cone mechanisms in the electroretinogram of the cynomolgus monkey.		1974	4206546
a comparison of retinal argon laser lesions in man and in cynomolgus monkey.		1974	4205338
effect of diet on hepatic and intestinal lipogenesis in squirrel, cebus, and cynomolgus monkeys.		1974	4215435
some biochemical characteristics of the salivary gland products of macaca irus and cercopithecus aethiops.		1974	4215613
[the communicative behavior of the crab-eating monkey macaca fascicularis raffles 1821].		1974	4220055
naturally occurring immune-complex glomerulonephritis in monkeys (macaca irus). i. light, immunofluorescence and electron microscopic studies.	light, immunofluorescence and electron microscopic studies were carried out on renal biopsies from 32 randomly selected adult monkeys (macaca irus). histopathology was limited to glomeruli and consisted of mild to moderate segmental increases in mesangial cells, mesangial matrix, and/or glomerular basement membrane (gbm) thickness in 41% of the animals. granular deposits of igm were present in the mesangial region and along the gbm in 72% of the monkeys, whereas igg, c1q, c4 and c3 were detected ...	1974	4276331
effect of synthetic lh-releasing factor (lrf) on lh secretion in monolayer cultures of the anterior pituitary cells of cynomolgus monkeys.		1974	4362039
experimental pertussis infection in the marmoset: type specificity of active immunity.	although we have failed to produce either paroxysmal cough or vomiting in rhesus monkeys, cynomolgus monkeys and marmosets, we have found in marmosets several features of pertussis infection similar to those seen in children with whooping cough: catarrh, persistence of colonization of the naso-pharynx with bordetella pertussis for 4-11 weeks, change of serotype during colonization and inability of type 1 organisms to establish themselves as the predominant serotype.as in children, we have found ...	1974	4362410
serological evidence of infection with tana and yaba pox viruses among several species of monkey.	sera from cynomolgus monkeys from malaysia, from indian rhesus monkeys, from various species of monkeys from africa and from south america have been examined for neutralizing antibody to tanapox and yaba viruses. no antibody was found to either virus in the sera of rhesus monkeys or south american monkeys. a certain proportion of sera from cynomolgus monkeys and various species of african monkey showed antibody to one or other of the viruses, but few of the positive sera showed antibody to both. ...	1974	4362411
epidemiology of myxo- paramyxovirus infections among cynomolgus monkeys imported for laboratory use.		1974	4372427
natural virus infection in green and cynomolgus monkeys.		1974	4377284
studies on the sequential immunization against group b arboviruses in squirrel monkeys, cynomolgus monkeys, rhesus monkeys, and chimpanzees.		1974	4204022
the effect of calcium beta glycerophosphate on phosphatase activity in plaque from monkeys (macaca fascicularis).		1974	12692919
[control of the menstrual cycle and fertility by progesterone in macaca fascicularis].		1974	4220066
sweating in the cynomolgus macaque (macaca fascicularis) exposed to ambient temperature of 40 degrees c.		1974	4475105
the crab-eating macaques (macaca fascicularis) of angaur island, palau, micronesia.		1974	4459218
a protracted startle response to maternal rejection in infants of macaca fascicularis.		1974	4435666
design of a cage for breeding and group behavioural studies of macaca fascicularis.		1974	4204193
in vitro production of sulphated mucosubstances by the labial and palatine glands of the monkey macaca irus.		1975	1054577
effects of triamcinolone acetonide on experimental oral candidiasis in monkeys.	thirteen adult monkeys (macaca irus) were infected with candida albicans by inoculating the microorganisms under an acrylic plate covering the palatal mucosa. six of the monkeys were treated with the steroid triamcinolone acetonide intramuscularly for 2 weeks before and 2 weeks after inoculation. the palatal mucosa was studied clinically and histologically at weekly or biweekly intervals for up to 5 months after inoculation. the cellular immune response was studied using the direct leukocyte mig ...	1975	1056095
prevention of streptococcus mutans infection of tooth surfaces by salivary antibody in irus monkeys (macaca fascicularis).	four irus monkeys (macaca fascicularis) were immunized with streptococcus mutans 6715 killed cells and cell products by injection in the vicinity of the major salivary glands and by instillation into the parotid glands via the ducts. after immune group and a sham-immunized control group of monkeys were infected orally with viable strain 6715 organisms. dental plaque samples were taken at intervals from the buccal and lingual grooves of the first permanent molars. these samples were evaluated for ...	1975	1097337
arterial fibrous proteins in cynomolgus monkeys after atherogenic and regression diets.	fibrous proteins were measured in five arterial beds in adult cynomolgus monkeys after administration of atherogenic and regression regimens. atherosclerosis was induced by feeding the monkeys a hypercholesterolemic diet containing 1.2% cholesterol for 17 months. a low-fat, cholesterol-free regression diet was then given for 60 days, 200 days, and 20 months. in atherosclerosis, collagen concentration (mg/g dry weight) and collagen content (mg/cm length of artery) both increased. at 200 days of r ...	1975	1116235
olfactory neuroepithelioma in a cynomolgus monkey (macaca fascicularis).	this is a report of an olfactory neuroepithelioma occurring in a male cynomolgus monkey (macaca fascicularis). it is not possible to state whether this tumor was spontaneous or related to the experimental procedures carried out in this animal.	1975	1123841
methacholine: a 7-day inhalation toxicity study with primates.	the acute and sub-acute inhalation toxicity of methacholine to cynomolgus monkeys was assessed by exposure of animals to an aerosol of a 2% solution of the material in sterile saline. the acute response was characterized by a decrease in tidal volume, increase in respiratory rate, a fall in dynamic compliance and an increased pulmonary resistance. onset of the acute response was rapid, reached a peak after 2-3 min of exposure and recovery appeared to be complete after 30 min following terminatio ...	1975	1129803
long-term exposure to sulfur dioxide, sulfuric acid mist, fly ash, and their mixtures. results of studies in monkeys and guinea pigs.	groups of cynomolgus monkeys and guinea pigs were exposed to mixtures of sulfur dioxide, fly ash, and sulfuric acid mist. the exposure concentrations varied between 0.1 and 5.0 ppm for sulfur dioxide, 0.1 and 1 mg/cu m for sulfuric acid mist, while a concentration of approximately 0.5 mg/cu m was used for fly ash. the duration of exposure was 52 weeks for guinea-pigs and 78 weeks for monkeys. pulmonary function tests and serum biochemical and hematological analyses were conducted prior to and pe ...	1975	1130840
estrogen and progesterone secretion in monkeys (macaca fascicularis) following melatonin or altschule's pineal extrac.	large doses (30mg) of melatonin given weekly to crab-eating monkeys throughout five menstrual cycles did not change the pattern of estrogen and progesterone secretion during the period of injection or in the two succeeding cycles. altschule's pineal extract, unlike melatonin, had no effect on estrogen or progesterone secretion during the period of injection or in the two succeeding cycles, when it was given daily between days 7 and 17 of the menstrual cycle.	1975	1132533
metabolism of 17-phenyl-18,19, 20-trinor-prostaglandin f2alpha in the cynomolgus monkey and the human female.	[9beta- -3h]-17-phenyl-18,19,20-trinor-pgf2alpha was injected subcutaneously into female cynomolgus monkeys and the structures of six products appearing in the urine were determined. the main urinary metabolites were the dinor- and tetranor-derivatives of 15-keto-13,14-dihydro-17-phenyl-18,19,20-trinor-pgf2alpha. unchanged 17-phenyl-18,19,20-trinor-pgf2alpha was also identified among the urinary products, as well as its dinor- and tetranor-derivatives. finally, the dinor-derivative of 13,14-dihy ...	1975	1135425
diet-induced aortic atherosclerosis in malaysian long-tailed monkeys (macaca irus).	moderate hypercholesterolaemia has been produced in eight adult male m. irus monkeys by feeding an egg-toast preparation containing butter and 0.14 per cent. total cholesterol. at autopsy, after two to four years of persistent hypercholesterolaemia, there was massive fatty streaking of the aorta involving 21 to 78 per cent. of the intimal surface. the distribution and morphology of the fatty streaks was similar to that in man. in addition, there were fibrous plaques including "soft" lipid-rich a ...	1975	1151525
a comparison of thermoregulatory responses in the japanese macaque (macca fuscata) and the crab-eating macaque (macaca irus) during cold exposure.	thermoregulatory responses in four male adult japanese macaques and four male adult crab-eating macaques, weighing 6-12 kg and 6.2-8 kg, respectively, were compared at ambient temperatures (ta) ranging from 5 degrees c to 25 degrees c. the average values +/- s.e. for some physiological measurements made at ta of 25 degrees c in the japanese macaque and the crab-eating macaque, respectively, were as follows: resting metabolic rate; 47.6 +/- 5.0 and 42.5 +/- 1.7 w/m2; tissue conductance; 11.9 +/- ...	1975	1152303
purification of zymogen granules from monkey parotid glands.	a method giving highly purified zymogen granules from macaca irus and cercopithecus aethiops parotid glands in reported. a 0.3 m sucrose medium for homogenization was supplemented with 10 mm tris/hcl, ph 7.3, and 0.1 mm lauric acid to stabilize the fragile monkey zymogen granules. nuclei and cell debris were sedimented at 150 times g. a "crude" zymogen granule fraction was trapped in the 1.0 m sucrose layer of a discontinuous sucrose gradient at 1000 times g. equilibrium centrifugation in a cont ...	1975	1155105
effect of administered human interferon on experimental rabies in monkeys.	cynomolgus monkeys infected with rabies virus were protected by repeated intramuscular administration of human leukocyte interferon beginning 24 h after infection.	1975	1168171
estrogen secretion and its relation to corpus luteum formation in monkeys (macaca fascicularis) given melatonin.	daily injection of 10 mg of melatonin from the 7th through the 17th day of the menstrual cycle in the crab-eating monkey delays the appearance of increased secretion of progesterone or prevents it altogether. in the cycles following melatonin treatment, the time in the cycle when the preovulatory estrogen rise occurs is more variable and the frequency of a second estrogen peak increases.	1975	1169173
effects of penfluridol and other drugs on apomorphine-induced stereotyped behavior in monkeys.	the effects of some drugs on apomorphine-induced stereotyped behavior were studied in male cynomolgus monkeys. apomorphine produced the dose-dependent stereotyped behavior characterized mainly by continuous licking and biting, and repetitive movements of the hands, head and body in the monkeys. penfluridol as well as haloperidol showed a clear antagonistic effect on the apomorphine-induced stereotyped behavior, while chlorpromazine was less antagonistic than haloperidol. the antagonistic effect ...	1975	1171014
the in vivo metabolism of cortisol and corticosterone by the macaque monkey (macaca fascicularis).	(4-14c) cortisol was administered intramuscularly to one adult female macaque monkey, mf3 (macaca fascicularis). to adult female macaque monkey, mf4, (4-14c)corticosterone was administered intramuscularly. urine samples were collected and the metabolites excreted identified using gas chromatography, radio-gas chromatography and gas chromatography-mass spectrometry. the principal metabolites of cortisol were identified as glucuronide conjugates of 11-oxygenated-17-oxosteroids. the excretion of te ...	1975	1172896
the characterization of polar corticosteroids in the urine of the macaque monkey (macaca fascicularis) and the baboon (papio hamadryas).	computerised gas chromatography-mass spectrometry was employed in the identification of polar corticosteroid metabolites excreted in the urine from the macaque monkey (macaca fascicularis) and the baboon (papio hamadryas). the following steroids were identified in significant amounts in the urine from both species: 3alpha,17alpha,20alpha, 21-tetrahydroxy-5beta-pregnan-11-one; 3alpha,17alpha,20beta,21-tetrahydroxy-5beta-pregnan-11-one; 5beta-pregnane-3alpha,11beta,17alpha,20alpha,21-pentol; 5beta ...	1975	1173507
hepatitis b core antigen in the immunosuppressed chimpanzee.	two chimpanzees with low levels of anti-hbs developed increased antibody titres but showed no antigenemia after i.v. administration of 10 ml infective chimpanzee serum. treatment of a chimpanzee (also possessing anti-hbs) i.m. with cyclophosphamide plus prednisolone for 3 weeks starting 2 days before the challenge with infective serum resulted in detectable circulating hbsag by day 67. by day 95, the hbsag concentration had increased to 17 times a human ag reference plasma and low titres of anti ...	1975	1204961
bilateral projections from precentral motor cortex to the putamen and other parts of the basal ganglia. an autoradiographic study in macaca fascicularis.	by tracing radioactively labeled proteins transported by axonal flow, projections from area 4 to the ipsi- and contralateral neostriatum and claustrum were demonstrated in 7 monkeys. a reversed topographic organization was found on both sides for the corticoneostriatal and corticoclaustral projections. the most extensive terminal field could be observed in the putamen. in contrast, very few area 4 efferents seemed to terminate in the caudate nucleus. this suggests differential functions for the ...	1975	50112
antibody response in the parotid fluid and serum of irus monkeys (macaca fascicularis) after local immunization with streptococcus mutans.	the antibody response of macaca fascicularis in parotid saliva and serum to local immunization by two routes with streptococcus mutans was studied and compared over 1 year. antibodies were titrated and classified by indirect immunofluorescent staining using specific antiglobulin conjugates. antiglucosyltransferase activity was assayed by an enzyme inhibition test. animals were immunized first by injecting formalin-killed bacterial cells and cell products subcutaneously into the vicinity of the f ...	1975	50286
human and monkey prolactin and growth hormone: separation of polymorphic forms by isoelectric focusing.	the feasibility of using isoelectric focusing for the separation of primate pituitary growth hormone from prolactin and for the characterization of polymorphic forms of these hormones was explored. in a ph 3--10 gradient, extracts of both human and cynomolgus monkey pituitaries were each resolved into 4 growth hormone components and at least 3 prolactin components, as shown by radioimmunoassay. in narrower gradients (of 2--3 ph units) greater resolution was achieved; the principal growth hormone ...	1975	227
experimental diarrhea in cynomolgus monkeys by oral administration with clostridium perfringens type a viable cells or enterotoxin.	purified c. perfringens type a enterotoxin fed orally in an amount of 5 mg caused both vomiting and diarrhea in the monkey only when the gastric juice had been neutralized. exposure of enterotoxin to ph 4.0 or below rapidly destroyed the activity. all three monkeys receiving sodium bicarbonate and 2.4 x 10(10) viable cells grown in ds medium developed diarrhea, and only one of them vomited once. the diarrhea lasted for 13, 18 and 19 hr. the symptoms were similar to those reported in human cases ...	1975	525
a comparative study on the presence of c-type viral particles in placentas from primates and other animals.	c-type particles are found in human, baboon, marmoset, rhesus, patas, and cynomolgus monkeys. a cebus monkey and two chimpanzee placentas have failed thus far to show the presence of these particles. of the nonprimate tissues examined one mouse and one guinea pig placenta were positive whereas a rabbit placenta was negative. variations in number of particles present in tissues as well as number of animals of a given species containing particles are noted. the isolation of foamyviruses from place ...	1975	169817
isolation of foamy virus from rhesus, african green and cynomolgus monkey leukocytes.	foamy virus (fv) was recovered regularly from the leukocyte of rhesus and cynomolgus monkeys and somewhat less often from african green monkey leukocytes. virus was found in virtually all organs of experimentally infected rhesus monkeys. no illness or pathologic abnormalities were noted in these animals or in any of the naturally infected animals in spite of the prolonged period of viral persistence in various organs and tissues.	1975	171409
diaphragmatic herniation of the liver in macaques demonstrated by intravenous hepatography.	a suspected diagnosis of diaphragmatic herniation of the liver in 2 monkeys (macaca fascicularis and macaca mulatta) was confirmed radiographically by using various contrast media. experimental compound ag 60.99, which is selectively concentrated in the liver and spleen, allowed excellent visualization of these 2 organs and confirmed the presence of a portion of the liver in the right thorax. cholografin meglumine was subsequently utilized to determine the location of the gall bladder. other pot ...	1975	173919
the pathogenesis of simian varicella virus in cynomolgus monkeys.	the mlm herpesvirus is infectious for cynomolgus monkeys. the disease in this species, possibly modulated by preinoculation antibody resembles human varicella. virus has been recovered from blood during the early incubation period, and from liver, lymph nodes, kidney, bladder and urine during the eruptive period of infection. the major target organs were skin and liver; specific pathological changes developed in both. appropriate antibody responses, including those to herpesvirus varicellae foll ...	1975	174129
pathogenesis of machupo virus infection in primates.	experimental machupo virus infection of rhesus and cynomolgus monkeys produced a severe illness consisting of an initial clinical phase and a later neurological phase. cumulative mortality during the two phases was 80% and 95% respectively. attempts to alter the pathogenesis with decomplementation or immunosuppression resulted in earlier deaths of the monkeys.	1975	182402
protection of monkeys against machupo virus by the passive administration of bolivian haemorrhagic fever immunoglobulin (human origin).	bolivian haemorrhagic fever immunoglobulin of human origin, given either prior to or shortly after experimental infection with machupo virus, protected rhesus and cynomolgus monkeys against initial clinical illness. some survivors developed severe neurological signs 30-47 days after virus inoculation and died 4-6 days later. results from one of the experiments suggested that the development of neurological signs was associated more frequently with high doses of immunoglobulin than with intermedi ...	1975	182406
the morphology of follicular development and ovulation in non-human primates.	a colony of macaca fascicularis have been under continuous observation for the past 4 years to ascertain the follicular morphological changes that occur prior to ovulation and during the development of the corpus luteum. of 609 experimental cycles, laparoscopy was performed at least once in 44-5% of the cycles. of the 104 cycles where the ovulatory status was definitely known, 89-4% were deemed ovulatory and 10-6% anovulatory. the presence or absence of ovulation in the previous cycle did not ha ...	1975	127041
the application of qae-sephadex for the purification of two staphylococcal enterotoxins. i. purification of enterotoxin c2.	a new method developed for purification of enterotoxin c2 from staphylococcus aureus strain 361 consisted of four steps: batchwise adsorption from culture supernatant on qae-sephadex; gel filtration on sephadex g-100; chromatography on qae-sephadex using a buffer of constant ph and molarity; and gel filtration using a volatile buffer of constant ph and molarity; and gel filtration using a volatile buffer as the eluting solvent. the purified enterotoxin appeared homogeneous by gel immunodiffusion ...	1975	237564
t-strain mucoplasmas and reproductive failure in monkeys.	t-strain mycoplasmas were isolated from the genital tracts of 3 genera of female monkeys: the talapoins, miopithecas talapoin, the patas, erythrocebus patas, and the macaques, macaca fascicularis. the talapoins have not reproduced successfully for the past 2 yr. fertility in the patas has also been reduced, with a high incidence of stillbirths and spontaneous abortions. the macaques were not permitted to breed.	1975	805883
the application of qae-sephadex for the purification of two staphylococcal enterotoxins. ii. purification of enterotoxin a.	the last three steps described in the preceding communication robern, h., stavric, s. and dickie, n. (1975) biochim. biophys. acta 000,000-000) were utilized successfully for the purification of enterotoxin a. the enterotoxin appeared homogeneous by gel chromatography and in the analytical ultracentrifuge but showed two bands on polyacrylamide disc electrophoresis at ph 4.5. the emetic dose, ed50, by intravenous route in cynomolgus monkeys was 0.12 mug/kg of animal weight. after treatment with b ...	1975	806302
effect of sodium phytate on the chemical and microbial composition of dental plaque in the monkey (macaca fascicularis)	the incorporation of 1 or 3% sodium phytate in confectioners sugar produced minimal changes in the physical,chemical, and microbial composition of dental plaque in tube-fed monkeys during a two-week period. only a reduction in yeasts and lactobacilli could be ascribed to the presence of phytate. other changes were attributable to the transition from conventional feeding to tube-feeding, irrespective of the presence of absence of phytate.	1975	806617
the influence of 2 br-alpha-ergocryptine (cb-154) and apomorphine on induced prolactin secretion in the crab eating monkey (macaca fascicularis).	the influence of apomorphine and 2 br-alpha-ergocryptine (cb-154) on drug-induced prolactin secretion was examined in an intact and an ovariectomized monkey (macaca fascicularis). perphenazine administered iv at one mg/kg bw induced a rapid and marked increase in serum prolactin. apomorphine at a concentration of 4 mg/kg bw administered prior to perphenazine delayed the perphenazine-induced prolactin rise. the iv administration of cb-154 at either 200 or 2000 mu-g/kg bw completely blocked the pe ...	1975	807469
sulphated macromolecules in dental plaque in the monkey macaca irus.		1975	808203
experimental oroparanasal communication in monkeys.	experimental oroparanasal communications were established in nine monkeys (macaca irus) through the alveoli of the maxillary first or second molars after extraction of these teeth. the communications between the maxillary sinus and the oral cavity were supported by use of a polyethylene catheter fixed with sutures. the observation time ranged from 1 to 6 days. histologic study of the maxillary sinus mucous membrane revealed inflammatory changes especially in the floor and the lower part of the w ...	1975	808503
erythroblastosis models. a review and new experimental data in monkeys.	the current status of erythroblastosis fetalis in man and in animals is briefly reviewed with emphasis on present knowledge of nonhuman primates as models for the disease. our studies in crab-eating macaques indicate that presence in a mother's serum of potent antibodies reactive for red cells for her fetus will not necessarily cause erythroblastosis; in one case the maternal antibodies did not penetrate the placental barrier, and in two cases although the fetal red cells were maximally antibody ...	1975	808623
maximum expiratory flow-volume studies on monkeys exposed to bituminous coal dust.	to assess early ventilatory responses at the 2 mg/m3 bituminous coal dust standard, 23 cynomolgus monkeys were exposed by inhalation to pennsylvania and utah coal dust. ten controls were utilized. pennsylvania coal was selected from a field having a high prevalence of coal workers' pneumoconiosis while the utah coal was selected from a low prevalence area. after 24 mo of exposure, a pattern of pulmonary impairment consistent with peripheral airway obstruction was demonstrated. reductions were ob ...	1975	809410
[retinal reactions to intense light. i. threshold lesions. experimental, morphological and clinical studies of pathological and therapeutic effects of laser and white light].	the effects of intense light produced by an argon laser, a helium-neon laser and a xenon are photocoagulator in the retinas of gray chinchilla rabbits, cynomolgus monkeys, and rhesus monkeys were studied clinically and histopathologically including electron microscopy. an improved experimental set-up was used allowing a very good consistency of the inflicted lesions. threshold lesions were produced in chinchilla rabbits and cynomolgus monkeys by an argon laser and a helium-neon laser. the lesion ...	1975	810008
sinusoidal flicker characteristcis of primate cones in response to heterochromatic stimuli.	electrophysiological recordings of primate photorecptors have been obtained and frequency response characteristics of the red, green and blue cones have been determined and compared to previous psychophysical findings. using cynomolgus monkeys, we recorded the foveal local electroretinogram, which is dominated by the late receptor potential, and obtained criterion-response threshold data for sinusoidally flickered test stimuli complementary chromatic adapting backgrounds. our results support the ...	1975	810550
effective body water half-life and total body water in rhesus and cynomolgus monkeys.	although body water content and effective water half-life have been determined in several mammalian species, including man, these measurements are not available for sub-human primates to our knowledge. values were therefore determined in a group of rhesus and cynomolgus monkeys. a fairly wide range of water half-life values was found in each of the two species between animals, but there was little variation within animals who had more than one determination over the course of 1 year. mean values ...	1975	811339
[changes in cellular activity in corpus luysi after stimulation of monkey corpus striatum].	in a chronic experiment on three awake macaca cynomolgus, the activity of 27 neurons localized in the corpus luysi was recorded. their spontaneous activity is continuous without rhythmicity or bursts. all neurons responded to a stimulation of the striatum by an initial activation followed by an inhibition. these facts reveal the occurrence of a double projection from the putamen and also from the head of the caudate nucleus to the corpus luysi.	1975	811384
[characterization of mycoplasms isolated from imported nonhuman primates (author's transl)].	mycoplasms were isolated from 35 (16%) of 215 specimens collected from 20 crab-eating monkeys (macaca irus), 9 green monkeys (cercopithecus aethiops) and from 9 common squirrel monkeys (saimiri sciurea). all these animals had been imported from south-east asia, africa and south america being apparently healthy. a total of 38 large and 20 small colony-mycoplasma strains were isolated from the nasal and oral cavity, urethra, vagina and rectal feces. the large colony-mycoplasmas could be differenti ...	1975	811474
resistance to psychopathology in adolescent monkeys (macaca fascicularis) reared with mothers and peers.		1975	811699
clinical note--a case of bilateral dental fistula in a cynamolgus monkey (macaca fascicularis).		1975	811928
ocular effects of clonidine in cats and monkeys (macaca irus).		1975	812714
schistosoma japonicum: immunopathology of nephritis in macaca fascicularis.		1975	812719
distribution of an 125i-labelled chloroquine analogue in a pregnant macaca monkey.	whole body autoradiography of a pregnant monkey (macaca irus) of late gestation was performed 72 h after an intravenous injection of the 125i-labelled chloroquine analogue 4-(3-dimethylaminopropylamino)-7-iodoquinoline (dapq). the overall distribution pattern in the monkey was similar to that which was earlier observed in rodents. a few species differences, however, were found in the monkey as compared to the rodents: a high accumulation in the inner part of the adrenal cortex, a high level in t ...	1975	813334
[artificial nursing of new-born cynomolgus monkeys as a model of the human infant and development of abnormal behavior (author's transl)].	new-born cynomolgus monkeys were sucessfully reared by artificial nursing that was started just afterbirth with a 12% solution of a commercially prepared powdered-milk (yukijirushi, p 7a) containing 13.3g of protein per 100g. marked growth-retardation was observed in baby cynomolgus monkeys fed on a 12% solution of the modified p 7a milk containing only 6.6g of protein per 100g to which lactose was supplemented to give a baby monkey the same caloric value as that of the original p 7a milk. these ...	1975	814006
[the weight of the reproductive organs, hypophysis and thyroid of male cynomolgus monkeys. (macaca fascicularis) (author's transl)].	the present short paper deals with the weight of the male reproductive organs of wild-imported cynomolgus monkeys, including the testes, epididymides, ductus deferens, vesicula seminalis prostata, bulbo urethralis and penis. in addition, the size of the testes and the weight of the thyroid and hypophysis are also presented.	1975	814007
histochemical studies on beta-glucuronidase activity in developing teeth and bone of rat and macaque monkey.	the enzyme beta-glucuronidase (e.c. 3.2.1.31.) has been studied in developing teeth and bone of sprague-dawley rats and macaque monkeys (macaca irus) by means of histochemistry using naphthol-as-bi-beta-d-glucuronide as substrate and hexazotized pararosanilin as coupling reagent. since beta-glucuronidase is sensitive to fixatives a freeze-sectioning technique has been used which made it possible to section highly mineralized tissues without previous fixation and decalcification. in the bone enzy ...	1975	823790
phenylalanine hydroxylase of macaca irus a simple purification by affinity chromatography.		1975	812698
effects of extraoral forces in the dentofacial complex of the macaca irus.		1975	829781
treatment of squamous cell carcinoma involving the buccal pouch in a crab-eating macaque.	persistent swelling of the left buccal pouch was noticed in an adult female crab-eating macaque (macaca fascicularis). a mass involving almost the entire musculature of the pouch was removed surgically. the histopahtologic diagnosis was squamous cell carcinoma. recurrence of the mass was treated by a combination of surgical excision and radiation therapy.	1975	809400
the effects of the removal of dominant animals in a small group of macaca fascicularis.	six juvenile macaca fascicularis relatively unfamiliar with one another were placed together in a large play apparatus. the boelkins' water test was used to establish dominance. after one hour of social interaction the animals formed a stable hierarchy. following six days of observation of this group, the dominant male and female were removed. this removal drastically altered the behavior of the remaining animals (19 of 40 behavior categories changed significantly). a replication indicated that ...	1975	1170280
lymphocyte cultures of macaca mulatta and macaca fascicularis.	lymphocytes of macaca mulatta and macaca fascicularis were cultured using a microculture technic. the use of rpmi-1640 with fetal calf serum as a culture medium and an extra dose of phytohemagglutinin produced excellent results. staining of the chromosomes by the gemsa banding technic did not reveal any differences between the karyotypes of the macaca species.	1975	1121162
regeneration of nasopharyngeal epithelium in macaca fascicularis.	regeneration of the nasopharyngeal epithelium in macaca fascicularis occurs as a result of migration of epithelial cells from the margins of the lesions as well as from the neighbouring glandular ducts and epithelial crypts. the study further reveals that the basal cells are the progenitors of both goblet and ciliated cells. the regenerating epithelium at first consists of mucus-containing cells which are finally converted into normal globlet and ciliated cells. the formation of centrioles and c ...	1975	1154996
[retrograde degeneration of the pyramidal cells in the motor cortex of apes (macaca fascicularis)].	in three adult macaques the retrograde degeneration of cell bodies in the motor cortex was investigated 6 months after unilateral pyramidal tract section. large and small betz cells of the fifth layer were identified microscopically and counted. the analysis of the data reveals that after pyramidotomy, (1) contrary to our expectations from the extent of the pyramidal lesions, a surprising percentage of undegenerated betz cells remains in the contralateral motor cortex, (2) a greater percentage o ...	1975	1154995
histomorphology of cervical and uterine epithelia of crab-eating macaque, macaca fasciularis.	cytological characteristics and pattern of distribution of different cell types in the epithelia of cervix and uterus of crab-eating macaque (macaca fascicularis) in follicular and luteal phases of the menstrual cyclic and amenorrhea were studied. the cervix uteri and uterus exhibit remarkable structural differenes in the ciliated, secretory, and ciliated-secretory cells. since the number of ciliated-sexretory cells in the uterus is higher than in the cervix. it is believed that they form an add ...	1975	1140748
[adrenosympathetic system and thermoregulation in a prosimian perodicticus potto].	the urinary excretion of catecholamines in perodicticus potto (1.76-2.94 mug/kg 24 h) is in the same range as in other mammals and the activity of the adrenosympathetic system does not account for the low metabolic rate in this species. the adrenals contain 1.140 +/- 0.14 mug a + na/mg fresh tissue, of which adrenaline constitutes 94.5 per cent and are thus practically identical to those in macaca irus. in a cold environment the daily urinary excretion of catecholamines of the tropical but cold ...	1975	129219
[dopamine of the caudate nucleus in perodictious potto, macaca mulatta and macaca fascicularis].	the dopamine, dopac and tyrosinehydroxylase contents of the caudate nucleus in the prosimian perodicticus potto and in the simii macaca mulatta and m. fascicularis have been estimated. the results do not support the hypothesis according to which the sluggishness of the potto is somehow related to a low dopamine content of part of the extrapyramidal system as found in the parkinson-syndrome.	1975	2371
loss of acute pilocarpine effect on outflow facility following surgical disinsertion and retrodisplacement of the ciliary muscle from the scleral spur in the cynomolgus monkey.	an ab-interno goniotomy-like operation for disinserting the ciliary muscle from the scleral spur in cynomolgus monkeys is described. following postoperative miotic and corticosteroid treatment, the eyes did well clinically and the muscle reattached to the sclera posterior to the spur. outflow facility and intraocular pressure were mildly reduced. there was drainage of aqueous humor via the conventional outflow routes, and blood flow to the ciliary body. the outflow facility increasing effect of ...	1976	824222
effects of paracentesis on the blood-aqueous barrier: a light and electron microscopic study on cynomolgus monkey.	the effects of paracentesis on the blood-aqueous barrier of cynomolgus monekeys were studied by light and electron microscopy. the following regions of the eye were examined: ciliary body, iris, schlemm's canal, juxtacanalicular connective tissue, and trabecular meshwork. prominent structural alterations were seen in the ciliary epithelium at the anterior portion of the pars plicata, but the epithelium at the posterior portion of the pars plicata and at the pars plana appeared less disrupted. pl ...	1976	824223
priming of macaca cynomolgus philippinensis with purified antigen of brucella melitensis before injection of rev. i vaccine.	in experiments designed for study of bacteremia and serologic response of macaca cynomolgus philippinensis to vaccination with a soluble antigen (fraction i) of brucella melitensis and the live rev. i vaccine strain, fraction i and rev. i were administered both four weeks apart and simultaneously. one of three monkeys given the vaccines four weeks apart and two of three monkeys vaccinated with fraction i and rev. i in a single injection developed transient bacteremia, as shown by blood cultures. ...	1976	824373
oral glucose tolerance test in the cynomolgus monkey (macaca fascicularis).	the glucose tolerance test was simplified so that it could be performed on more than one cynomolgus monkey (macaca fascicularis) at a time. glucose was administered orally in a dose of 2 g/kg body weight as a 50% aqueous solution, and blood samples were taken just before and 30 minutes and 150 minutes after glucose administration. the simplified test was conducted on a total of 93 cynomolgus monkeys. glucose tolerance curves obtained by this method were classified into three patterns with regard ...	1976	824499
initial colonization of teeth in monkeys as related to diet.	the initial phases of plaque development on nonretentive tooth surfaces were studied bacteriologically in macaca irus monkeys fed by stomach tube and provided with various oral supplements. except for the oral implantation of streptococcus mutans in some of the animals, the oral flora was not changed prior to the studies. dental plaque was allowed to develop on initially cleaned tooth surfaces for 3 to 5 h. plaque samples were collected and cultured on a number of selective and nonselective agar ...	1976	825462
an outbreak of epistaxis in cynomolgus monkeys (macaca fascicularis).		1976	826008
studies on the treponema pallidum immobilizing activity in normal human serum. 5. on the protective role against syphilis.	it was shown that t. pallidum immobilized in vitro by normal serum had lost its infectivity in rabbits. this finding suggested that the immobilizing activity of normal serum might play a role in the natural resistance of man against infections with t. pallidum. however, the results of serological studies of acquired early syphilis in man and of experimental syphilis in cynomolgus monkeys did not present evidence that the immobilizing activity of normal serum protected against syphilis infection.	1976	826114
effect of chemical modifications on the metabolic transformation of prostaglandins.	the metabolism of three analogues of pgf2alpha was studied in the cynomolgus monkey and in the human, viz., 15-methyl-pgf2alpha, 16,16-dimethyl pgf2alpha, and 17-phenyl-18,19,20-trinor-pgf2alpha. the half-lives of the three compounds in the human circulation was considerably longer than that of pgf2alpha. the dehydrogenation of the secondary alcohol group at c-15 was completely blocked in the two first-mentioned compounds. these were degraded mainly by beta-oxidation, and their main metabolites, ...	1976	826142
protrusions of the inner wall of schlemm's canal.	large specific protrusions of the trabecular meshwork into schlemm's canal (hernias) have been suggested to be the main drainage routes for aqueous humor, similar to the function of the arachnoid villi in draining the cerebrospinal fluid. my quantitative study in cynomolgus monkeys does not support such a hypothesis. the drainage routes of the aqueous humor, evaluated from the number and sizes of the pores observed by scanning electron microscopy, were as common through the hernias as through ot ...	1976	826163
blood groups of bonnet macaques (macaca radiata), with a brief introduction to seroprimatology.	the human-type a-b-o blood groups of 52 bonnet macaques (macaca radiata) were determined. application of method of population genetics indicated the gene frequences to be 0 = 0.173, a = 0.480 and b = 0.347. cross testing of sera and red cells of the bonnet macaques revealed two blood-type-specific isoagglutinins, one of them strong enough for use as a blood typing reagent. no blood group polymorphism was revealed by testing bonnet macaque red cells with isoantisera produced in rhesus monkeys (m. ...	1976	826172
influence of cholinergic receptor blockade on drug-induced prolactin release in the monkey.	the influence of varying doses of perphenazine, thyrotropin-releasing hormone (trh) and serotonin on prolactin release was examined in two species of monkeys: rhesus (macaca mulatta) and crab-eating (macaca fascicularis). the intravenous administration of 0.33 mg/kg body weight of perphenazine or 1.0 mug/kg body weight of trh gave a greater release of prolactin than higher doses of perphenazine (1.0 mg/kg) or trh) (3.4 mug/kg), respectively. prolactin release induced by serotonin at doses of 1, ...	1976	826472
[antifertility effect of an active immunization of monkeys with human pregnancy-specific beta 1-glycoprotein (sp1) (author's transl)].	fertile female cynomolgus monkeys (macaca fascicularis) were actively immunized against human pregnancy-specific beta 1-glycoprotein (sp1). native sp1 as well as chemically modified derivatives of sp1 served as antigens. the effect of the immunization on reproduction in these animals was investigated. the immunized monkeys showed a significant reduction in fertility: the conception rate in these animals was only slightly reduced when compared with the controls; but in the immunized monkeys pregn ...	1976	827272
chemical composition of cynomolgus monkey milk.	milk samples from eight cynomolgus monkeys whose lactation period ranged 44-119 days were investigated for their gross chemical composition such as total solids, crude protein, lipids, lactose and ash. nitrogen distribution, compositions of fatty acids, amino acids and triglycerides as well as major minerals were also determined. these analytical data were compared with those reported for man, simian and cow, and cynomolgus monkey milk was found to have close similarities to human milk.	1976	827449
comparative study of the banding patterns of the chromosomes of cercopithecidae. i. subfamily papinae: macaca fascicularis and papio sphinx.	the diploid number of macaca fascicularis and papio sphinx is 42. all chromosomes are biarmed. using g-banding techniques, the complements of these two species have been compared. the topography of the bands is identical in all but one chromosome pair, showing a small pericentric inversion. the results indicate the existence of an extreme conservation in the arrangement of the genetic material and that changes at the gene level may have contributed to speciation in the papinae.	1976	827484
studies on pancreatic islet accumulation and cytotoxicity of n-nitrosomethylurea in the cynomolgus monkey.		1976	828134
[experimental gingivitis by feeding soft food containing sucrose. repeated observation in a macaca irus monkey (author's transl)].		1976	829780
failure of carbon monoxide to induce myocardial infarction in cholesterol-fed cynomolgus monkeys (macaca fascicularis).	twenty-six adult female cynomolgus monkeys (macaca fascicularis) were randomly assigned to four groups which were fed on a standard laboratory diet or a semipurified diet containing cholesterol. in two of the groups, the monkeys were exposed intermittently to co throughout the day for 14 months; the control animals breathed room air. no myocardial infarctions were observed, and the ecg showed a transitory injury current in only one animal. no differences in plasma cholesterol levels or in aortic ...	1976	815001
experimental dirofilariasis in macaques. iii. susceptibility and host responses to dirofilaria tenuis of raccoons.	in this third of a series of studies on experimental dirofilariasis in primate hosts, 3 macaca cynomolgus, 6 m. speciosa, and 2 m. mulatta were inoculated with infective larvae of dirofilaria tenuis, a parasite of the raccoon, and were killed at periods ranging from 2 weeks to 13 months of infection. one m. mulatta and one m. speciosa were treated daily with prednisolone beginning 2 months after inoculation; worms were recovered from these and 5 other monkeys (7 of 11). microfilaremia was detect ...	1976	816216
thalamic projections from the precentral motor cortex in macaca fascicularis.	radioactive amino acids were injected into area 4 in 7 monkeys (macaca fascicularis). ipsilateral corticothalamic projections were traced to olszewski's nucleus ventralis lateralis pars oralis and pars medialis, the nucleus ventralis posterior lateralis pars oralis, the nucleus ventralis posterior medialis and inferior and to the nucleus reticularis. some fibers appeared to terminate in the ipsilateral nucleus ventralis lateralis pars caudalis, the nucleus lateralis posterior and the nucleus sub ...	1976	816421
immunization of macaca fascicularis (macaca irus) monkeys with streptococcus mutans: specificity of antibody responses in saliva.	m fascicularis monkeys were immunized subcutaneously in the vicinity of the major salivary glands and by retrograde infusion into the parotid duct, with a vaccine containing formalin-killed s mutans strain 6715 cells and culture-fluid antigens. indirect immunofluorescent staining was used to titrate and classify antibodies. subcutaneous immunization induced only a serum response, whereas intraductal infusion stimulated both an iga antibody response in the parotid fluid and a serum response. immu ...	1976	816835
aggravation of atherosclerosis by hypertension in a subhuman primate model with coarctation of the aorta.	the interrelationships between hypertension and atherosclerosis were investigated in a subhuman primate model (cynomolgus monkey) with hypertension produced by surgically coarcting the miathoracic aorta. the hypertensive coarcted monkey fed a low cholesterol diet for 6 months did not develop complicating atherosclerosis but did develop focal intimal lesions as well as marked thickening of the musculoelastic media of both the large and small arteries. fibrocellular thickening of the intima and me ...	1976	817849