Publications

the influence of traumatic intrusion of primary teeth on their permanent successors. a radiographic and histologic study in monkeys.	intrusion of maxillary central primary incisors was performed in 18 green vervet monkeys (cercopithecus aethiops) with the purpose of studying early and late histologic changes in odontogenesis of permanent tooth germs and the effect of treatment of primary tooth injury. immediate changes were studied in five monkeys where both maxillary central primary incisors were intruded. the monkeys were sacrificed 10-15 min after intrusion. the immediate changes in the permanent tooth germ consisted of co ...	1976	824213
the intercollicular area of the inferior colliculus.	to study the somatosensory input to the inferior colliculus, lesions were made in the dorsal column nuclei of the hedgehog, tree shrew, slow loris, marmoset and african green monkey, and spinal cord of the hedgehog, tree shrew and slow loris. the degenerating fibers stained with silver impregnation methods. the dorsal column system projects primarily to an area lateral to the central nucleus of the inferior colliculus, whereas the spinotectal projection is primarily to the medial region in the h ...	1976	825188
malnutrition and susceptibility to infection with vibrio cholerae in vervet monkeys (cercopithecus aethiops). 1. induction of protein, b-vitamin complex and calorie malnutrition.	five groups of eight vervet monkeys (cercopithecus aethiops) were fed regular monkey chow, low protein (lp), low b-vitamin complex (lbv), low protein - low b-vitamin complex (lb-lbv), or protein - low calorie (lp-lc) diet, respectively, for eight weeks. hematocrit values, hemoglobin, bun, total protein, albumin, riboflavin and body weight decreased, the ratio of dispensable/indispensable amino acids increased in all animals receiving a deficient diet. total globulin, igg and igm remained unchang ...	1976	826634
malnutrition and susceptibility to infection with vibrio cholerae in vervet monkeys (cercopithecus aethiops). 2. response of vervet monkeys on protein, b-vitamin complex and calorie-deficient diets to infection.	five groups of vervet monkeys (cercopithecus aethiops) were fed regular monkey chow, low protein (lp), low b-vitamin complex (lbv), lp-lbv, or low protein- low calorie (lp-lc) diets, respectively. after eight weeks the animals were infected with cholera vibrios. igg, iga and igm increased in the sera of all animals after the challenge but the avidity of the immunoglobulins was lower in vervets on lp diets. diarrhea and excretion of vibrios lasted longer in animals consuming less protein.	1976	828672
interpretative differences in cytogenetic analyses: preliminary results of a collaborative study.	in an effort to establish some of the parameters which influence differences in interpretation of chromosome aberrations, we initiated a collaborative study with 26 different laboratories located in the u.s., canada and europe. they include government, private industry, and academic institutions. three species were selected for study which vary in chromosome number and complexity of the karyotype. these were the chinese hamster, human, and african green monkey. each metaphase was preselected and ...	1976	829598
cell-mediated immunity to respiratory syncytial virus induced by inactivated vaccine or by infection.	transformation and increased mitotic activity in donor lymphocytes exposed to specific antigens is considered by many to be a manifestation of cell-mediated immunity. in attempts to understand the apparent "sensitization" of individuals to respiratory syncytial virus (rsv) as a result of receiving inactivated rsv vaccine, in vitro lymphocyte transformation studies were carried out on infants who had received inactivated rsv vaccine and on infants who had received a similarly prepared inactivated ...	1976	1246465
nuclease s1 cleavage and the primary structure of mitochondrial dna.	the single-strand-specific nuclease s1 from aspergillus oryzae rapidly converts superhelical mitochondrial dna (african green monkey cells, vero atcc; ccl 81) into nicked circular dna. these nicked mitochondrial dna molecules contain two nicks, one in each strand. the phosphodiester backbones are cleaved during this reaction at or near sites that are alkali-labile. in a second slow reaction the circular mitochondrial dna is converted into a linear duplex dna. permutation tests indicate that this ...	1976	1261542
leucine 2,3-aminomutase, an enzyme of leucine catabolism.	the initial step in the fermentation of leucine to acetate, isobutyrate, and ammonia by clostridium sporogenes is the b12 coenzyme-dependent conversion of alpha-leucine to beta-leucine (3-amino-4-methylpentanoate). the amino group migration reaction, catalyzed by leucine 2,3-aminomutase, is reversible and is inhibited by intrinsic factor. the enzyme activity has been found in several clostridia, in rat, sheep, rhesus, and african green monkey livers, and in human leukocytes.	1976	1270414
characterization of a spontaneous undifferentiated carcinoma from an african green monkey (cercopithecus aethiops).	an adult male african green monkey (cercopithecus aethiops) with an undifferentiated carcinoma, probably originating from the nasal mucosa, was received from the akron, ohio zoo. cultivation of this tumor in vitro resulted in a mixture of fibroblastic and epithelial cells which was subsequently separated using differential trypsinization. the neoplastic nature of the cultured epithelial cells was verified by their ability to transplant into athymic nude, or antithymocyte serum-treated mice, wher ...	1976	184033
morphological observations on the replication of herpesvirus saimiri in monkey kidney cell cultures.	owl and african green monkey kidney cell cultures have been infected with 1 p.f.u./cell of herpesvirus saimiri and sample cultures have been taken for examination by electron microscopy at 3 to 6 hourly intervals over a period of 7 days; the experiments were repeated several times. the peculiarly slow replication cycle of herpesvirus saimiri has enabled distinct cytoplasmic and nuclear phases in virus maturation to be clearly distinguished; the overall fine structural features were similar in bo ...	1976	184242
a scanning electron microscopic study of sv40 infected cells.	the surface of the sv40-infected african green monkey kidney (agmk) cells was studied morphologically by scanning electron microscopy. in 24 hr post infection (p.i.), the cell surface was covered with slightly elongated microvilli. the microvilli increased in number. in 96 hr.p.i. most of the cells showed sv40-specific cytopathic effects (cpe). nuclear swellings and the elongation of microvilli were eminent. microvilli were observed projecting with high densities especially on the nuclear portio ...	1976	184324
in situ hybridization of repetitive monkey genome sequences isolated from defective simian virus 40 dna.	the origin of a repetitive monkey dna sequence that is incorporated into a defective simian virus 40 genome has been studied. a fragment (about 140 base pairs in length) containing essentially all the repetitive monkey dna present in the defective and few, if any, sv40 sequences can be cleaved from the purified defective dna by restriction endonucleases hind(ii and iii). radioactive crna prepared with the isolated fragment as template was hybridized in situ to african green monkey chromosomes. t ...	1976	184962
linkage of the genes for thymidine kinase and galactokinase in the african green monkey and the chimpanzee.		1976	185024
two adenovirus type 2-simian virus 40 hybrid populations that contain the entire sv40 genome differ in their ability to induce sv40 transplantation immunity in hamsters but not in mice.	ad2++ hey and ad2++ ley are two adenovirus 2(ad2)-simian virus 40 (sv40) hybrids distinguished by differences in the efficiency with which they produce sv40 progeny in lytically infected african green monkey kidney cells. these virus populations are composed of nonhybrid ad2 and hybrid virions, the majority of which contain more than 1 unit of sv40 dna. the ad2++ hey and ley populations also differ in their ability to induce sv40 transplantation immunity in rodents. only ad2++ hey induces sv40 t ...	1976	185429
serum lipid and lipoprotein responses of six nonhuman primate species to dietary changes in cholesterol levels.	the response of serum lipids and lipoproteins to different levels of cholesterol in the diet was studied in chimpanzee (pan troglodytes), rhesus (macaca mulatta), green (cercopithecus aethiops), patas (erythrocebus patas), squirrel (saimiri sciurea) and spider (ateles sp.) monkeys. five animals of each species were fed increasing amounts of dietary cholesterol (0.05% to 1.5% w/w) for 3-week periods; between each experimental diet, the animals were fed a basal diet without cholesterol for a simil ...	1976	186573
linkage relationship between the genes for thymidine kinase and galactokinase in different primates.	in this study we investigated the expression of primate galactokinase in somatic cell hybrids between a thymidine kinase-deficient mouse cell line and two different primate cell lines, one of which was derived from african green monkey kidney cells and the other from chimpanzee fibroblasts. all the african green monkey-mouse hybrid clones, selected in hat medium, expressed monkey galactokinase activity and contained a monkey chromosome similar to a human e-group chromosome. when these clones wer ...	1976	195352
biology of sv40 transplantation antigen (trag). i. demonstration of sv40 trag on glutaraldehyde-fixed sv40-infected african green monkey kidney cells.		1976	176782
comparative sensitivity of the bgm cell line for isolation of enteric viruses.	the bgm line of african green monkey kidney cells was less sensitive than primary rhesus monkey kidney cells or human fetal diploid kidney cells for isolation of certain echoviruses and adenoviruses from fecal specimens.	1976	178630
characterization of simian cells tranformed by temperature-sensitive mutants of simian virus 40.	seven lines derived from primary african green monkey kidney cells, which had survived lytic infection by wild-type simian virus 40 (sv40) or temperature-sensitive mutants belonging to the a and b complementation groups, were established. these cultures synthesize sv40 tumor (t) antigen constitutively and have been passaged more than 60 times in vitro. the cells released small amounts of virus even at high passage levels but eventually became negative for the spontaneous release of virus. virus ...	1976	178917
[demonstration by immunofluorescence of somatotropic cells and prolactin cells in the monkeys erythrocebus patas, cercopithecus aethiops and papio hamadryas].	using antibodies against human sth and ovine prolactine, it is possible to identify somatotropic and prolactin cells in the pituitary anterior lobe of three species of monkeys: erythrocebus patas, cercopithecus aethiops and papio hamadryas. the somatotropic cells are numerous in both adult and infant male or female monkeys, especially in the lateral lobes of the pituitary gland. the prolactin cells can be distinguished in all pituitaries studied, regardless age or sex; indeed there are more nume ...	1976	140737
search for epizootic-like venezuelan encephalitis virus at enzootic habitats in guatemala during 1969-1971.	seventy-four strains of venezuelan encephalitis (ve) virus recovered from sentinel hamsters or mosquitoes at enzootic habitats in guatemala in the two years following the 1969 epidemic-equine epizootic were examined for ability to produce small plaques in vero african green monkey kidney cell cultures, like isolates obtained during the epizootic. (a) one strain recovered from a sentinel hamster in late october 1969 at an enzootic habitat near the epicenter of the hemagglutination-inhibition (hi) ...	1976	7138
drug biotransformation in microsomes from the fetal stumptailed macaque, macaca arctoides: hepatic n-demethylation.	the kinetics of the n-demethylation of benzphetamine, ethylmorphine, meperidine, and methadone have been studied in microsomes isolated from livers of the fetal stumptailed macaque (macaca arctoides) during the last third of gestation. the apparent km for each substrate did not change during this time period. values were similar to those from livers of adult african green monkeys. the vmax for each substrate, when expressed per mg of microsomal protein, did not change during the last third of ge ...	1976	10140
cultivation of viral agents from crohn's disease. a new sensitive system.	the isolation and animal transmission of a viral agent from crohn's disease patients stimulated studies aimed at the development of improved tissue culture techniques. the need for an effective tissue-culture system led to a comparison of african green monkey tissue-culture cells (a.g.m.k.), human diploid lung cells (wi-38), and a new tissue-culture line--continuous rabbit ileum (c.r.i.). homogenates prepared from ileal specimens from four crohn's disease patients and from four control patients ...	1976	59237
safety of viral vaccine cell substrates: a reevaluation.	primary cultures of african green monkey kidney and rabbit kidney as well as diploid cell lines wi-38 and dbs-frhl-2 were examined for evidence of tumorigenicity and latent rna tumor viruses. cells inoculated into immunosuppressed newborn hamsters and rhesus monkeys were not tumorigenic. cells treated with 2'-deoxy-5-iodouridine to induce the production of latent viruses were examined by electron microscopy, density gradient centrifugation, and the reverse transcriptase enzyme assay. no evidence ...	1976	63564
characterisation of an epizootic haemorrhagic disease virus.	a high titre of epizootic haemorrhagic disease (ehd) virus was obtained from roller bottles of african green monkey kidney (vero) cells. cell associated ehd virus was purified by use of genetron-113 and sonication. purified viral particles were probably icosahedral with a diameter of 58 nm and contained capsomeres which appeared to be composed of five and six subunit structures. phenol extracted nucleic acid from purified ehd virus when treated with orcinol or diphenylamine gave colour reactions ...	1976	968187
virucidal effect of certain chemical contraceptives on type 2 herpesvirus.	the virucidal effect of several chemical contraceptives was investigated and the findings are rrported. the supension of type 2 herpes simplex virus, containing 10(6) to 10(7) tissue culture infectious doses per 0.1 ml., was inactivated on exposure to five different chemical contraceptives. for quantitative estimates of virucidal effect, 10 per cent solutions of these chemical contraceptives were tested with an exposure time of 10 minutes at room temperature. the methods for determination of res ...	1976	984103
[karyotyping of the cercopithecus (cercopithecus aethiops). banding and nomenclature].	the karyotype of cercopithecus aethiops was analysed by rhg, gtg, and c banding, and a band nomenclature is proposed.	1976	825016
biochemical characteristics of certain salivary glycoproteins from cercopithecus aethiops.		1976	825084
basic, proline-rich glycoproteins in the submandibular gland secretion of the cercopithecus aethiops.		1976	819210
influence of semipurified diets on atherosclerosis in african green monkeys.		1977	64369
a serum factor requirement for the passage of cultured vero cells through g2.	when vero cells, a line derived from and african green monkey kidney, are grown under conditions where the saturation density is limited by serum, they deplete the growth medium of a factor necessary for cell division. the factor is a component of serum. when vero cells are plated at low density (2 x 10(4)/cm2) in this depleted growth medium (after dialysis against serum-free dulbecco's modified eagle's medium) they initiate an unbalanced program of growth. protein synthesis proceeds at the same ...	1977	65356
[identification of monkey chromosomes by differential staining with romanovsky--giemza stain. iii. cercopithecus aethiops].	the distribution of the g-bands in chromosomes of bone marrow cells of cercopithecus aethiops was studied by means of differentail staining with the romanovsky - gimsa dye. all the homologous chromosome pairs were identified and morphometric parameters were detected. the comparison of c. aethiops karyotypes with those of macacca mulatta has shown that they are different in numbers and in the character of banding pattern of the most chromosomes. both species revealed 12 pairs of chromosomes simil ...	1977	72018
leucocyte migration inhibition test as an index of immunological response to measles virus i. effect of the environment and measles virus on migration of monkey leucocytes.	the parameters of migration inhibition test of leucocytes isolated both from the peripheral blood, spleen and lymph nodes of monkeys cercopithecus aethiops were determined. concentration of measles virus that does not produce nonspecific migration inhibition of leucocyte obtained from sero-negative animals was also defined.	1977	75672
leucocyte migration inhibition test as an index of immunological response to measles virus ii. immunogenic activity of measles virus.	experiments discussed in this paper aimed at obtaining, using cercopithecus aethiops monkeys information on immunogenic activity of measles virus as well as kinetic and persistence of immunological reaction at active and inactivated virus.	1977	75673
characteristics of poliovirus type 3 strains after passage through monkey central nervous system.	cercopithecus aethiops monkeys were inoculated intracerebrally with sabin's type 3 polivoirus strain, and with strains isolated from subjects vaccinated with leon 12a1b and from their contacts. sample of brain, spinal cord, kidneys, lymph nodes, blood and spinal fluid were taken. from these materials, (except of kidneys) 23 poliovirus strains of type 3 were isolated. genetic markers rct 40.3, rct 41, d and ist were determined for these strains. the changes observed in genetic markers of strains ...	1977	15438
role of normal cell antigens in the establishment of measles virus in newborn white mice.	the edmontson strain of measles virus was adapted to the brains of newborn white mice to which extracts from african green monkey kidney (vero) cells used for maintenance of measles virus had been injected intracerebrally. the animals showed symptoms of involvement of the central nervous system (pareses, paralyses) which reappeared in subsequent passages.	1977	17289
ultrastructure of sensory nerve terminals in the penis in green monkey (cercopithecus aethiops sabaeus).	tje paper describes the ultrastructure of axons in the endings of various types from the corium in the glans penis in green monkey. in the meissner's endings the axons are mostly completely enveloped in the plasma of schwann cells. they contain numerous mitochondria which are partially vacuolated or are quite converted into vacuoles. next, there are pseudomyelinated figures, light vesicles and further organelles. in the papillar simple glomerular endings with accumulation of schwann cells there ...	1977	99893
african green monkey fibroblast actin morphology during sv40 infection.	monkey skin fibroblasts were infected with simian virus 40. cells that exhibited the viral tumor antigen were found to retain the normal morphology of actin filaments up to six days after infection. however when cells were transformed in terms of focus formation they had lost the normal actin morphology.	1977	195416
mycoplasma in african green monkey kidney cell cultures: biochemical detection and effects in virus-infected cells.	among a number of techniques for the detection of mycoplasmal contamination in african green monkey kidney (agmk) cell lines, the assay of uridine phosphorylase activity is unsuitable because of the presence of high levels of endogenous enzymatic activity. a thymidine phosphorylase test, however, based on the chromatographic analysis of radiolabeled thymidine breakdown, turned out to be a simple and sensitive mycoplasma detection method. we found, using the latter technique, that 0.22-micrometer ...	1977	195895
characterization of simian virus 40 transformed african green monkey cells (cv-1). i. defective virion and viral genome.	several clones of sv40 transformed cv-1 cells have been characterized for the production of t- and v-antigens and for the state of viral genome. the transformed cv-1 cells failed to produce infectious virions as assayed after sonication or cocultivation and fusion with normal cv-1 cells, and were resistant to super-infection by sv40. some clones of the transformed cells contained v-antigens. the population of v-antigen positive cells varied from 0 to 100% depending on the passage number while th ...	1977	196162
[demonstration by immunofluorescence of adenohyphysis corticotropin and melanotropin cells in erythrocebus patas, cercopithecus aethiops and papio hamadryas].	using antibodies against synthetic corticotropic hormones (1-24 acth and 17-39 acth), and melanotropic hormones (alpha-msh and beta-msh), it is possible to identify corticotropic and melanotropic cells in the adenohypophysis of three species of monkeys : erythrocebus patas, cercopithecus aethiops and papio hamadryas. the corticotropic cells are numerous in the anterior lobe in both the adult and infant male and female monkeys of these three species. the intermediate lobe reacts with antibodies a ...	1977	196718
structure and formation of circular dimers of simian virus 40 dna.	most of the viral dna extracted from simian virus 40 (sv40)-infected african green monkey kidney cells consists of circular molecules about 5.3 kilobases in contour length. however, about 1% of the viral dna was found to occur as closed circular dimers that appeared to be formed, preferentially, late in infection. the monomeric units of dimers were organized in a head-to-tail, tandem arrangement; moreover, the monomeric units were not defective; i.e., they lacked deletions or other rearrangement ...	1977	198580
characterization of simian virus 40-transformed african green monkey cells (cv-1). ii. semipermissive character for viral replication.		1977	200829
histone synthesis during infection of monkey kidney cells with simian virus 40.	the synthesis of histones during lytic infection of bsc-1 (african green monkey kidney) cells with sv40 has been investigated. the synthesis of all five classes of histones was stimulated, and all classes appeared to be stimulated to the same extent. the increase in rate of histone synthesis in response to sv40 infection was detectable several hours before sv40 dna synthesis was measureable, and the rate of histone synthesis decreased at a time when sv40 dna synthesis was occuring at a maximal o ...	1977	200893
nonhuman primates: laboratory animals of choice for neurophysiologic studies of sleep.	a systematic study was made of several nonhuman primates to learn more about their relative usefulness for studies of sleep. species studied included the guinea baboon (papio papio), kenya or yellow baboon (p cynocephalus), olive baboon (p anubis), sacred baboon (p hamadryas), vervet monkey (cercopithecus aethiops), rhesus monkey (macaca mulatta), bonnet monkey (m radiata), crab-eating monkey (m fascicularis), patas monkey (erythrocebus patas), chimpanzee (pan troglodytes), mongoose lemur (lemur ...	1977	201798
activation of epstein-barr virus in hybrid cells.	human-primate hybrid cell lines were established by fusion of african green monkey kidney cells (vero) with lymphoblastoid cells from patients with infectious mononucleosis (im)(imk101) and from burkitt's lymphoma culture (hr1k). both epstein-barr virus (ebv)-specific antigens and ebv particle-containing cells increased in the hybrid lines (imk1-1/vero,hr1k/vero). treatment of the hybrids with 5-bromodeoxyuridine induced more antigen-positive and more virus-containing cells. ebv could be activat ...	1977	192898
properties of permissive monkey cells transformed by uv-irradiated simian virus 40.	african green monkey cells (cv1 line) were infected with uv-irradiated simian virus 40 (sv40), and permissive lines of stably transformed cells were established. these cell lines display the sv40 t-antigen and the growth characteristics typical of nonpermissive transformed cells (e.g., reduced cell density inhibition, reduced serum dependence, ability to overgrow normal cells, and colony formation in soft agar). the level of permissiveness to superinfecting sv40 is fully comparable with that of ...	1977	194053
subunit structure of chromatin and the organization of eukaryotic highly repetitive dna: nucleosomal proteins associated with a highly repetitive mammalian dna.	component alpha dna is a homogeneous, highly repetitive fraction that comprises nearly a quarter of the african green monkey (cercopithecus aethiops) genome. by restriction enzyme analysis, it has a repeat periodicity of 176 +/- 4 nucleotide base pairs, corresponding closely with the length of dna contained within a nucleosome. the sequence is organized into large blocks of constitutive heterochromatin. a method is described here for the isolation of intact polynucleosomal arrays containing only ...	1977	269392
subunit structure of chromatin and the organization of eukaryotic highly repetitive dna: indications of a phase relation between restriction sites and chromatin subunits in african green monkey and calf nuclei.		1977	416220
experimental palatal candidosis and saliva flow in monkeys.	maxillary acrylic plates, inoculated with candida albicans, were inserted for 3 weeks in 10 monkeys (cercopithecus aethiops) (series i), and reinserted in five of the animals 8 weeks after removal (series ii). to suppress saliva flow oxyphencyclimine was injected intramuscularly (0.125 mg/kg) thrice daily for 3 weeks in six monkeys of series i, while four controls received no drug. in series ii the oxyphencyclimine dose was doubled in three animals, and two controls were sham-treated with sodium ...	1977	402689
the african green monkey as an alternate primate host for studying machupo virus infection.	african green monkeys (cercopithecus aethiops) are highly susceptible to bolivian hemorrhagic fever (bhf). six monkeys were inoculated with 1,000 plague-forming units of machupo virus, the etiologic agent of bhf. they were observed and monitored for clinical signs, body temperature, viremia, hematologic changes, and virus neutralizing antibody. onset of fever, anorexia, and depression was noted on days 3 to 6 postinoculation. these and other signs increased in severity and all monkeys died: 5 of ...	1977	402863
differential habitat utilizati of four cercopithecidae in a kenyan forest.	the presence of papio cynocephalus, cercopithecus mitis, cercopithecus aethiops and colobus angolensis in a small coastal forest is attributed to their differential habitat utilization. data on diet, space-use patterns and polyspecific associations are given. habitat partitioning is found to be resource-related and is accomplished through differential reliance on resources as well as different means of exploiting overlapping resources. the implications of the data for understanding the relations ...	1977	403113
analysis of the alpha-satellite dna from african green monkey cells by restriction nucleases.	by the use of restriction endonucleases the organization of the alpha-satellite dna from african green monkey cells (cercopithecus aethiops) has been analyzed. with endo r-hindiii, endo r-alui and with endo r-ecori at conditions of low salt and high ph (endo r-ecori) all of the satellite was digested while only a part of the satellite was cleaved with endo r-bsu and endo r-ecori under standard conditions. with each of the four nucleases a series of fragments was formed which were multiplies in s ...	1977	404149
assay of escherichia coli heat-labile enterotoxin with vero cells.	the continuous cell line of african green monkey kidney, vero, showed characteristic morphological changes in response to culture filtrates from toxigenic strains of escherichia coli. the response compared favorably with that of y-1 (mouse adrenal) and cho (chinese hamster ovary) cells. vero cells were the simplest and most economical to maintain in the laboratory.	1977	405326
spectral and orientation specificity of single cells in foveal striate cortex of the vervet monkey, cercopithecus aethiops.	1. the spectral sensitivity, orientation specificity and inhibitory surround of seventy-three cells were studied in the vervet monkey. the eye was in the dark or illuminated with steady white or spectral light. the cells were in the striate cortex corresponding to the foveal representation. nearly all the cells gave on- or on/off-responses.2. more than a third of the cells (41%) responded over a narrow spectral band, in the blue, green, yellow or red section. three quarters of them were orientat ...	1977	406386
respiratory pathogens in non-human primates with special reference to corynebacterium ulcerans.	an investigation of 272 non-human primates (75 macacca cynomolgus, 97 macacca mulatta and 100 cercopithecus aethiops) revealed a high incidence of respiratory disease caused by corynebacterium ulcerans, staphylococci, diplococci and streptococci. escherichia coli was also found as a secondary invader. most of the infections occurred during winter in macaca cynomolgus and were caused by corynebacterium ulcerans and diplococcus pneumoniae. the c. ulcerans strains were phage type vi g. a phage typ ...	1977	407395
application of freeze-dried monkey erythrocytes to measles viral hemagglutination and hemagglutination-inhibition tests.	erthrocytes collected from monkey species including grivet, rhesus, and cynomolgus monkeys were stabilized by fixation with glutaraldehyde of a low concentration and were freeze-dried in vacuo. these freeze-dried erythrocytes were compared with fresh erythrocytes for measles viral hemagglutination and hemagglutination inhibition and could be used in both tests instead of fresh erythrocytes. they maintained their initial appearance and sensitivity to measles viral hemagglutinins after storage at ...	1977	408375
[comparative characteristics of corticosteroid metabolism in lower simians and man].	corticosteroid metabolism has been investigated in macaca mulatta, papio hamadryas, cercopithecus aethiops, erithrocebus patas and man. similar character of corticosteroid metabolism in monkeys and man was found. significant interspecific differences with respect to quatitative and qualitative parameters of the metabolism of steroid hormones were found. in this respect m. mulatta and p. hamadryas are most similar to man as compared with other monkeys. these two species may be used as an adequate ...	1977	409003
formazan cells in protein and protein-calorie malnutrition.	formazan cells were less numerous in the peripheral blood of vervet monkeys (cercopithecus aethiops) receiving a "o" protein-low calorie diet than in animals fed a full or a protein but not calorie deficient diet.	1977	409269
polymorphonuclear neutrophilic leukocytes in protein deficiency.	the number of white blood cells and of polymorphonuclear leukocytes remained unchanged in vervet monkeys (cercopithecus aethiops) receiving a "o" protein diet. the motility of the polymorphonuclear leukocytes and their phagocytic and killing indices with and without leukokinin stimulation decreased in protein-depleted animals. acid cathepsin decreased, dna relatively increased, and peroxidase, alkaline phosphatase, acid phenylphosphatase, and lysozyme reached higher levels in the polymorphonucle ...	1977	409270
effect of oral estramustine phosphate on pituitary, gonadal, and adrenal function in the green monkey (cercopithecus aethiops sabaeus).	we studied the effects of estramustine phosphate on pituitary, gonadal, and adrenal function in the green monkey. a 2-week course of estramustine phosphate (75 mg per day) reversibly suppressed the luteinizing hormone and testosterone response to luteinizing hormone-releasing hormone but did not affect pituitary-adrenal function assessed by the 11-deoxycorticosterone response to metyrapone. treatment with oral estramustine phosphate also resulted in a significant increase in corticosteroid-bindi ...	1977	409695
evidence for alkali-sensitive linkers in dna of african green monkey kidney cells.		1977	409957
the susceptibility to praziquantel of schistosoma haematobium in the baboon (papio anubis) and of s. japonicum in the vervet monkey (cercopithecus aethiops).		1977	410180
aflatoxin b1, a selective inhibitor of dna synthesis in mammalian cells.	aflatoxin b1 in concentrations between 0.01 and 0.1 microgram/ml inhibits dna synthesis in african green monkey cells in culture, but has little effect on rna synthesis and no effect on protein synthesis. the drug even at concentrations up to 1.0 microgram/ml does not interfere with dna repair promoted by ultraviolet irradiation nor does it induce dna repair. the inhibition of dna synthesis attains maximum values 3 h after addition of aflatoxin b1 and is irreversible upon removal of the drug. pr ...	1977	410504
[steroid metabolism in primates. xix. urinary excretion of c21-steroids in cercopithecus aethiops and erythrocebus patas].	in male cercopithecus aethiops (green monkey; grivet) and erythrocebus patas (dancing red monkey; patas monkey), the pattern of urinary c21 steroids was estimated and compared with those of man, baboon and rhesus monkey. the results indicate diminished 11 beta- and 17 alpha-hydroxylation in steroid biosynthesis as well as diminished delta 4-3-keto reduction and increased 20 beta-reduction in metabolism in these two species.	1977	411649
whole-body cholesterol metabolism in cholesterol-fed african green monkeys with a variable hypercholesterolemic response.		1977	411859
myocardial lesions in cercopithecus aethiops monkeys.		1977	412346
ultrastructural study of cell cultures infected with swinepox and orf viruses.	monolayer cells of a porcine kidney cell line were infected with the pp-1 strain of swinepox virus, while secondary or third subcultured monolayer cells of african green monkey kidney were inoculated with the iwate bt-9 strain of orf virus. those infected cells were fixed when cpe became remarkable in the monolayers and examined by electron microscope. in the cytoplasm of cells infected with both viruses, various immature forms of viral particles in different developmental stages were observed. ...	1977	412491
the ciliary body and the suspension of the lens in a monkey (cercopithecus aethiops). a scanning electron microscopic study.	the zonules of zinn and their insertion on the ciliary body and the lens in a monkey (cercopithecus aethiops) have been studied with the scanning electron microscope. the specimens were dissected after drying by the critical point method, and the lens was separated from the ciliary body by simple traction. the pars plana was completely covered by a mat which consisted of meridionally directed zonule-like fibers. most of these fibers inserted at the base of the posterior end of the ciliary proces ...	1977	413329
human-type a-b-o blood group antigens of ethiopian vervet monkeys (cercopithecus aethiops) in the wild.	human type a-b-o blood group antigens were tested in a local population of ethiopian vervet monkeys (cercopithecus aethiops). one animal was of group ab, the others were a. this represents a lower rate of polymorphism at this locus than has been observed among south african populations of the same species.	1977	864678
[research on the rubella epidemic of 1973 in turin. virological data].	during the outbreak of rubella in turin in 1973, 110 newborns, whose mother's pregnancy clash with the epidemic, were studied for the elimination of rubella virus. 708 samples were in total examined, through inoculation in primary cultures of african green monkey kidney (and study of the possible interference with echo-virus type 11), and partially in rk 13 and sirc continuous cell lines. no strain of rubella virus was isolated, and the authors conclude that the virus involved was particularly b ...	1977	871345
isolation and biological characterization of a measles virus-like agent from the brain of an autopsied case of subacute sclerosing panencephalitis (sspe).	isolation of a cytopathic agent causing formation of syncytial giant cells in co-cultivated vero cells from the brain of an autopsied case of subacute sclerosing panencephalitis (sspe) is reported. the syncytia usually autolyzed from the center after growing to 1 to 2 mm in diameter and then detached from the culture vessels, and finally made macroscopically recognizable round plaques on the monolayer under liquid overlay. the agent was identified serologically as an agent related to measles vir ...	1977	875761
concanavalin a induced inhibition of cell migration in african green monkey kidney cell cultures.	the effect of concanavalin a (con a) on the mobility of vero cells into cell free gaps is examined. the movement of cells into these wounds is inhibited by a 30 minute exposure of con a at a concentration of 12.5 ug/ml. the effects of con a on the mobility are dependent on the concentration of the lectin used for treatment as well as the total amount of time the cells are exposed to a given concentration. the con a inhibition is abrogated by alpha-methyl-mannose. the competitive effects of con a ...	1977	892581
persistent infection of cultured mammalian cells by japanese encephalitis virus.	persistent infections were established by serial undiluted passage of flavivirus japanese encephalitis virus in a line of rabbit kidney cells (ma-111). the persistently infected cells resembled uninfected cells in most respects. low levels of infectious virions were released from a small percentage of cells, and a larger and more variable percentage was shown to possess viral antigen by fluorescent-antibody staining. released viruses were shown to interfere with replication of wild-type japanese ...	1977	916028
sensory nerve endings in the penis in green monkey (cercopithecus aethiops sabaeus).	the authors examined the sensory innervation of the skin in the penis in green monkey in four adult individuals both in the light and in the elctron microscope. they found 3 kings of nerve endings. the free nerve endings were the most frequently occurring kind of nerve endings in the superficial layers of the corium--altogether 6,444 in number. the second kind of sensory nerve endings is represented by the glomerular endings out of which 96 per cent were found in the papillae. the typical meissn ...	1977	417480
further studies on the association of herpes simplex virus type 1 dna with host dna during productive infection.	our previous finding of an association between herpes simplex virus type 1 (hsv-1) and african green monkey kidney (bsc-1) dnas in productively infected cells has been extended by investigating the influence of the time course, temperature, and multiplicity of infection on the extent of this association. the interaction of host and viral dnas was not only dependent on the concentration of intracellular viral dna, but also upon the particular conditions of infection. an examination of the time co ...	1977	18625492
carcinogenic and other adverse effects of procarbazine in nonhuman primates.	the carcinogenic potential of procarbazine is under investigation in three species (macaca mulatta, macaca fascicularis, and cercopithecus aethiops) of nonhuman primates. a total of 55 monkeys have received procarbazine s.c., p.o., or i.p. for periods of up to 12 years. eleven of the 42 monkeys (26%) necropsied thus far have had malignant neoplasms, 6 of which were acute leukemia. two monkeys developed osteogenic sarcomas, two monkeys developed hemangiosarcomas, and a single case of lymphocytic ...	1978	418874
mitochondrial rna and protein synthesis in enucleated african green monkey cells.		1978	565412
establishment and characterization of a subacute sclerosing panencephalitis (measles) virus persistent infection in bgm cells.	infection of bgm cells with the halle isolate of subacute sclerosing panencephalitis (sspe) gave rise to a persistent infection (bgm/halle), whereas infection of another african green monkey kidney cell line (vero) under identical conditions led to a lytic infection. the bgm/halle cells multiplied more slowly than the non-infected cells (even when the medium was changed daily). under such conditions 10(7) to 10(8) p.f.u./ml/24 h of measles virus was released into the medium. it was established t ...	1978	641529
excision repair of ultraviolet damage in mammalian cells. evidence for two steps in the excision of pyrimidine dimers.	the incidence of pyrimidine dimer formation and the kinetics of dna repair in african green monkey kidney cv-1 cells after ultraviolet (uv) irradiation were studied by measuring survival, t4 endonuclease v-sensitive sites, the fraction of pyrimidine dimers in acid-insoluble dna as determined by thin layer chromatography (tlc), and repair replication. cv-1 cells exhibit a survival curve with extrapolation number n = 7.8 and do = 2.5 j/m2. pyrimidine dimers were lost from acid-insoluble dna more s ...	1978	656544
formation of phenylalanine transfer rna lacking the wye base in vero cells during methionine starvation.	vero, a cell line derived from african green monkey kidney, normally contains a single species of trnaphe (trna2phe), containing a hypermodified base, wye (originally called y), next to the 3' end of the anticodon. when methionine is removed from the growth medium, there appears a new trnaphe species (trna1phe) lacking the wye base and eluting early from reversed phase chromatography columns. its appearance is not due to the cessation of cell growth. addition of methionine to cells containing bo ...	1978	681356
structure and replication of echovirus type 12. 1. analysis of the polypeptides and rna of echovirus 12 particles.	the propagation of echovirus 12 in green monkey kidney (gmk) cells, a continuous cell line, is described. virions and empty capsids are purified to homogeneity by cscl density and by velocity centrifugation. the protein composition of the particles as compared to poliovirus 2 particles is analyzed by dodecyl sulfate/polyacrylamide gel electrophoresis. infectious virions were found to be composed of four different polypeptide chains of molecular weights 33,000, 31,000, 24,000 and 7,000. some addi ...	1978	729593
caliciviruses infecting monkeys and possibly man.	caliciviruses have, for the 1st time, been shown experimentally to infect a primate. twenty-four hours after being inoculated with san miguel sea lion virus (smsv), an african green monkey developed a febrile response and vesicular lesions at injection sites. virus was recovered from lesion material 96 hours later and from the stool at 48 hours. possible human infection with smsv was indicated by serologic evidence. three persons working with 4 distinct serotypes of smsv developed neutralizing a ...	1978	415648
effect of oral pancreatic enzymes on the course of cholera in protein-deficient vervet monkeys.	the effect of pancreatic extract on the course of cholera infection in protein-deficient vervet monkeys (cercopithecus aethiops) was studied. eleven animals were made protein deficient by diet. thier intestinal pancreatic enzyme concentration decreased as they became protein depleted. these animals were then challenged with vibrio cholerae. four control animals given a standard diet were similarly challenged. immediately after challenge, 6 of the protein-deficient monkeys were given a highly pur ...	1978	415928
bacterial endocarditis with obstruction of the right atrioventricular orifice and the pulmonary outflow trace in an african monkey (cercopithecus aethiops).	a 7 to 8-year-old male african green monkey (cercopithecus aethiops) was found moribund in his cage. fluid and antibiotic therapy were administered, but the monkey dies 2 hours later. at necropsy, large septic mural thrombi obstructed the right atrioventricular orifice and the pulmonary outflow tract, and smaller septic thrombi were attached to the leaflets of the pulmonary and mitral valves. staphylococci were isolated from the large thrombus occluding the atrioventricular orifice. large absces ...	1978	416298
the prevalence of hepatocystis kochi in african green monkeys.	the prevalence of hepatocystis kochi was studied in 178 african green monkeys from kenya and 61 from ethiopia. examinations of blood smears for gametocytes and examinations of the livers for merocysts were performed to determine the presence of infection in these animals. the overall prevalence of infection was 29%. no significant difference in infection rate was found between monkeys from the different geographic areas or between males and females.	1978	417213
propagation of pneumocystis carinii in vero cell culture.	pneumocystis carinii derived from infected murine lung was found to be capable of limited growth in vero african green monkey kidney cell cultures. the observed increase in the number of cyst forms was influenced by the ratio of cysts to host cells in the inocula, duration of passage, and formulation of the cell culture media. maximum growth was achieved by inoculating 1.3 x 10(5) cysts per 75-cm2 flask containing about 2 x 10(7) vero cells (cyst-to-cell ratio=1:154) maintained on minimal essent ...	1978	307535
[assignment of alpha-fuc to1p in man and the chimpanzee and to chromosome 4 in the african green monkey].	analysis of cellular hybrids confirms the assignment of alpha-l-fucosidase (alpha-fuc) to 1p in man. discordant results are in favour of the following gene order: 1pter (eno-1, alpha-fuc,ak2) pgm1 centromere pep-c but give no information on the relative positions of eno-1,alpha-fuc, and ak2. the assignments of alpha-fuc to chromosome 1 in the chimpanzee and to chromosome 4 in the african green monkey are demonstrated (chromosome nomenclature by finaz et al, 1976). these results confirm the homol ...	1978	308341
density-dependent regulation of growth of bsc-1 cells in cell culture: control of growth by low molecular weight nutrients.	bsc-1 cells, epithelial cells of african green monkey kidney origin, show pronounced density-dependent regulation of growth in cell culture. growth of the cells is rapid to a density of approximately 1.5 x 10(5) cells/per cm(2) in dulbecco-modified eagle's medium supplemented with 10% calf serum. above this "saturation density," growth is much slower. it has been found that the glucose concentration in the culture medium is important in determining the "saturation density." if the glucose concen ...	1978	272650
highly reiterated sequences of simiansimiansimiansimiansimian.	a 172-base pair segment of dna that is repeated several million times in the genome of the african green monkey has been characterized. sequence analysis revealed that the many repeats of this complex unit are not all identical but represent a set of closely related segments: sequence divergence occurs at various positions in the segment in a nonrandom manner. the uncloned segment obtained from monkey dna is compared with a cloned segment of the same dna which was recombined into the genome of s ...	1978	205944
transformation of african green monkey kidney cells with the rf strain of human papovavirus bkv.		1978	206005
cae i: an endonuclease isolated from the african green monkey with properties indicating site-specific cleavage of homologous and heterologous mammalian dna.	component alpha dna is a highly repetitive sequence that comprises nearly a quarter of the african green monkey (cercopithecus aethiops) genome. a previous microbial restriction enzyme analysis showed that the repeat structure of component alpha dna is based upon a monomeric unit of 176 +/- 4 base-pairs. an endonuclease, provisionally termed case i, has been isolated from african green monkey testes that cleaves component alpha dna into multimeric segments based upon the same repeat periodicity ...	1978	206873
phenotypic complementation of the sv40 tsa mutant defect in viral dna synthesis following microinjection of sv40 t antigen.	african green monkey cells (cv-1p) were microinjected with highly purified sv40 t antigen using protein-loaded red cell ghosts and polyethylene glycol as fusagen. the microinjected cells were infected with a temperature-sensitive mutant of sv40 (tsa209) which is defective in the initiation of viral dna synthesis. using in situ hybridization as an assay method, we found that peg-microinjection of both partially and highly purified t antigen resulted in an increase in the amount of viral dna sequ ...	1978	210962
the process of wound healing of the avascular outer layers of the retina. light- and electron microscopic studies on laser lesions of monkey eyes.	the process of wound healing of the avascular outer layers of the retina is studied on a series of laser lesions of the monkey, cercopithecus aethiops. the extent of the retinal lesions is limited to the pigment epithelium and photoreceptor cells, whereas bruch's membrane and the vascular inner layers of the retina intact. the retinal lesions are not seen to be invaded by cells from the choroid, nor from the retinal vessels. during the first three days after irradiation the pigment epithelial ce ...	1978	211792
the turnover of trnas microinjected into animal cells.	red cell-mediated microinjection has been used to study trna turnover in sv3t3 mouse cells and tc7 cells, an african green monkey kidney line. the turnover of endogenous trna, measured by labeling with 3h-methionine, was first-order with half-lives of approximately one day in sv3t3 and two days in tc7 cells. 32ptrna isolated from e. coli or tc7 cells turned over at the same rate as endogenous trna when injected into either sv3t3 or tc7 cells. this demonstrates that cellular processes, not proper ...	1978	214762
comparative sensitivity of various cell culture systems for isolation of viruses from wastewater and fecal samples.	in efforts to define the most sensitive cell culture systems for recovery of viruses from wastewaters, 181 samples were inoculated in parallel into tube cultures of various cell types and were plaqued in bottle and petri dish cultures of three types of monkey kidney cells. polioviruses were recovered most frequently in the rd line of human rhabdomyosarcoma cells, group a coxsackieviruses in rd and human fetal diploid kidney (hfdk) cells, group b coxsackieviruses in the bgm line of african green ...	1978	215087
reduction of herpes simplex virus-type 2 plaque formation by urea.	the effect of urea on plaque formation by herpes simplex virus type 2 (hsv-2) was examined in two systems at concentrations within or approximating the range found in human urine. approximately 7--10 mg urea/ml, added 2, 4, or 8 hours after infection, reduced plaque formation by 50% in african green monkey kidney cells. the growth of this system was affected slightly by continuous treatment with urea at 7--10 mg/ml. plaque formation was reduced in the monkey kidney system, albeit diminishingly, ...	1978	215721
dnas of simian virus 40 and polyoma direct the synthesis of viral tumor antigens and capsid proteins in xenopus oocytes.	purified simian virus 40 and polyoma dnas injected into nuclei of xenopus oocytes were transcribed and subsequently translated into virus-specific tumor antigens and capsid proteins. simian virus 40 large and small tumor antigens synthesized in the oocytes were indistinguishable, by gel electrophoresis and [35s]methionine-labeled tryptic peptide mapping, from the corresponding polypeptides synthesized in cv-1 african green monkey cells. the synthesis of large simian virus 40 tumor antigen implie ...	1978	216012
evidence for the existence of a single enzyme catalyzing the phosphorylation of choline and ethanolamine in primate lung.	choline kinase (atp:choline phosphotransferase, ec 2.7.1.32) has been isolated and purified 1000-fold from adult african green monkey lung with a yield of 10%. the purified enzyme also phosphorylated ethanolamine (ratio of ethanolamine kinase to choline kinase = 0.30). this ratio remained constant throughout the purification procedure. the km for choline (3.0 - 10(-5) m) was lower than that of ethanolamine (1.2 - 10(-3) m.) choline was also found to inhibit ethanolamine kinase activity by 50% at ...	1978	216394
heterogeneity in the low density lipoproteins of cholesterol fed african green monkeys (cercopithecus aethiops).	the low density lipoproteins of cholesterol-fed african green monkeys were isolated by either preparative ultracentrifugation or agarose column chromatography, then radioiodinated and fractionated by agarose column chromatography. a marked variation was noted in the specific radioactivity of the column fractions regardless of the method used to obtain low density lipoproteins. the radioactivity in each fraction migrated with the beta-globluins, but when the fractions were mixed with carrier plas ...	1978	216395