Publications

mptp-induced parkinsonism in the common marmoset: behavioral and biochemical effects.		1987	2881443
4-phenylpyridine and three other analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine lack dopaminergic nigrostriatal neurotoxicity in mice and marmosets.	c57 black mice were injected repeatedly with maximal tolerated doses of 2 chemical analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp); 4-phenylpyridine and 4-phenyl-1,2,3,6-tetrahydropyridine. although both compounds were clearly acutely toxic to mice, neither caused any reduction in striatal dopamine content after chronic exposure. two mptp analogues which may be formed endogenously during the metabolism of brain monoamines, 2-methyl-1,2,3,4-tetrahydroisoquinoline and 2-methyl-1,2 ...	1987	3106859
the ultrastructure of early implantation in the marmoset monkey (callithrix jacchus).	the ultrastructural morphology of the initial stages of implantation in the marmoset monkey (callithrix jacchus) was studied in pregnant monkeys at known time intervals after ovulation. the earliest samples, obtained 13 days after ovulation, displayed both cytotrophoblast and syncytiotrophoblast. the cytotrophoblast was restricted to the blastocoel, whilst syncytiotrophoblast intruded to the endometrial basal lamina. at later stages, days 16 and 19 after ovulation, both cytotrophoblast and syncy ...	1987	3103485
a new heterotopic callosal projection of primary visual cortex in the monkey, callithrix jacchus.	a callosal projection of area 17 upon the dorsomedial visual area in the marmoset monkey was demonstrated by means of retrograde transport of neuronal tracers. the projection was restricted to those regions representing the vertical meridian in the two areas. this finding, and the data of other authors, indicate that the monkey area 17 projects transcallosally onto homotopic and several heterotopic targets.	1987	3103864
influence of dietary fats on blood coagulation and prostaglandin production in the common marmoset.	common marmosets were fed a standard marmoset diet (ref) or diets supplemented with 12% (wt/wt) sunflower seed oil (sso) or sheep fat (sf) for a period of 90 weeks. the values for coagulation indices, clotting time, and russel viper venom time were consistent with decreased thrombotic tendency of platelets from animals on the sso diet relative to the low fat, ref diet animals, while an increased tendency to thrombosis was observed with sf-fed marmosets. the sso- and sf-supplemented marmosets sho ...	1987	3107535
active immunization against renin in normotensive marmoset.	primate renins (human and monkey) are very similar. we used pure human renin to immunize marmosets (callithrix jacchus) and thereby produce a chronic blockade of the renin-angiotensinogen reaction. after a control period of 2 months, five male marmosets, on their usual sodium-poor diet, were immunized against pure human renin by three subcutaneous injections of 30 micrograms each, with complete and then incomplete freund's adjuvant. three marmosets were injected with adjuvant only and served as ...	1987	3108891
determination of ovulation and pregnancy in the marmoset (callithrix jacchus) by monitoring of urinary hydroxypregnanolone excretion.	in callithrix jacchus the urinary excretion of hydroxypregnanolone (5 alpha-pregnane-3 alpha, 7 alpha-diol-20-one) shows a luteal rise during the ovulatory cycle. this progesterone metabolite can therefore be used as an indication of ovulation, implantation, and subsequently for the persistence of the pregnancy. the excretion can be monitored by high performance thin-layer chromatography (hptlc) and postchromatographic derivatization after enzymatic hydrolysis of the conjugate. profiles of urina ...	1987	3112406
rats and marmosets respond differently to serotonin agonists and antagonists.	the actions of the serotonin precursor 5-hydroxytryptophan (5-htp), the agonist 5-methoxy-n,n-dimetyltryptamine (meodmt) and quipazine (qpz) and the antagonists cyproheptadine, methysergide and metergoline, were studied in the rat and in the common marmoset (callithrix jacchus). the precursor and agonists elicited head shakes, forepaw padding, splayed hindlimbs, tremor and straub tail in the rat. however, head shakes were not observed after meodmt and straub tail was not observed after qpz. carb ...	1987	3114802
the measurement of ethylenethiourea and ethyleneurea in the rat and common marmoset callithrix jacchus after zineb (zinc ethylenebisdithiocarbamate) dosing.	the metabolism of the fungicide zineb, (zinc ethylenebisdithiocarbamate), has been studied in the rat and the marmoset. 2. it was found in both species that a relatively large proportion (21-22%) of the original zineb administered was detectable in the excreta as ethylenethiourea (etu) a known mutagen, teratogen and carcinogen. 3. a further proportion (2-5%) was determined to be ethyleneurea which is a metabolite of etu. 4. results of comparative experiments in marmosets revealed that etu was ph ...	1987	3114968
partial purification and characterization of chorionic gonadotrophin in plasma and in culture medium of trophoblast cells from the marmoset monkey (callithrix jacchus).	a biologically active gonadotrophin has been purified from the media of long-term cultures of trophoblast cells of the common marmoset monkey by a combination of precipitation and chromatography. marmoset chorionic gonadotrophin (cg) is a glycoprotein which binds concanavalin a and wheat germ agglutinin. the protein purified from culture media exists as several isoelectric species with pi in the range ph 3.5-4.5. on gel filtration it eluted with an apparent molecular weight of 68-72,000 but on p ...	1987	3116232
difference in serum ascorbate in two species of callithricidae.	in one species each of the subfamilies marmosets and tamarins of the new world monkey family callithricidae, serum levels of ascorbic acid were compared. although the feeding regimen had been the same for both species for several years, the average concentration of serum ascorbate in the tamarins saguinus fuscicollis (n = 21; 0.54 +/- 0.29 mg/100 ml) was only one-fifth that of the marmosets callithrix jacchus (n = 19; 2.56 +/- 1.07 mg).	1987	3119508
characteristics of trophoblastic tissue derived from in vitro culture of preimplantation embryos of the common marmoset monkey.	the features of trophoblastic tissue derived from the in vitro culture of marmoset monkey embryos have been described. long-term trophoblast cultures (in excess of three years in one case) were established from the primary trophoblast monolayer of four of 38 embryos; division of one of these embryos produced two long-term cultures. the trophoblast cells retained their ability to synthesize and secrete chorionic gonadotrophin (cg) during maintenance in vitro and were capable of prolonging the lut ...	1987	3120174
dietary lipid modulation of myocardial beta-adrenergic mechanisms, ca2+-dependent automaticity, and arrhythmogenesis in the marmoset.	dietary lipid supplements high in either saturated fatty acids derived from sheep perirenal fat or polyunsaturated fatty acids (65% linoleic acid) derived from sunflower seed oil were fed to marmoset monkeys (callithrix jacchus) for 20 months. the effect of these long-term dietary lipid supplements on myocardial contractile function and their influence on responses to isoprenaline and external calcium concentration were examined using isolated papillary muscles and atria. isoprenaline potency wa ...	1987	2444777
in vitro immortalization of marmoset cells with three subgroups of herpesvirus saimiri.	sequences within the rightmost 7 kilobases of the unique l dna of herpesvirus saimiri are required for oncogenicity of the virus. the same dna region has been found to be highly variable among different strains of herpesvirus saimiri. on the basis of this variability, herpesvirus saimiri strains were classified into groups a, b, and non-a, non-b. herpesvirus saimiri strains representing the three groups were used successfully for in vitro immortalization of phytohemagglutinin-activated, interleu ...	1987	2822956
protection of junín virus-infected marmosets by passive administration of immune serum: association with late neurologic signs.	argentine hemorrhagic fever (junín virus) is a human viral disease for which immune therapy proves effective, though a late neurologic syndrome is occasionally associated with the treatment. we attempted to determine in the infected marmoset callithrix jacchus whether immune therapy leads to protection and/or cns damage. fifteen c jacchus were inoculated with 10(3) tissue culture infectious dose 50% (tcid50) of the xj strain of junín virus. on day 6 post infection (pi), 12 primates were treated ...	1987	3025358
successful infection of the common marmoset (callithrix jacchus) with human varicella-zoster virus.	the common marmoset, callithrix jacchus, can be infected with human varicella-zoster virus (vzv), both wild-type strain kmcc and attenuated vaccine strain oka/merck. infection was accomplished with either whole-cell-associated or cell extract vzv by combined oral-nasal-conjunctival application and was characterized by substantial and persistent anti-vzv antibody responses. the infectivity of vzv for marmosets was destroyed by treatment of inocula with heat or uv light. diluted inocula with as fe ...	1987	3041014
the effects of cryopreservation and transfer on embryonic development in the common marmoset monkey, callithrix jacchus.	embryos were collected at the 4-10-cell stage from the oviducts (day 4; day 1 = ovulation) or as morulae (day 7) from the uterus of marmosets and frozen in 1.5 m-dmso (days 4 and 7) or 1.0 m-glycerol (day 4 only), using a slow freezing and thawing technique. of 22 day-4 embryos frozen in dmso, 18 were recovered and 16 of these were transferred to 10 synchronized recipients; 7 recipients became pregnant compared with all 7 control recipients receiving 10 unfrozen embryos. fifteen frozen-thawed mo ...	1987	3820175
the influence of linoleate and vitamin e from sunflower seed oil on platelet function and prostaglandin production in the common marmoset monkey.	vitamin e and linoleate, both of which are found in high concentrations in sunflower seed oil, were examined independently for their influence on general and blood-vascular parameters in vitamin e-deficient common marmosets. a vitamin e-deficient diet (-e, 4 micrograms/g) was supplemented with either 40 micrograms/g vitamin e (+e), vitamin e stripped sunflower oil (+10% sso-e), or sso (+10% sso w/w) in a 2 x 2 factorial designed experiment, and the diets fed for 9 months to 4 even groups of comm ...	1987	3437342
controlled ovulation in the marmoset monkey (callithrix jacchus) with human chorionic gonadotropin following prostaglandin-induced luteal regression.	controlled induction of ovulation in the marmoset monkey was attempted with a single injection of human chorionic gonadotropin (hcg; 50 iu) given on day 7 after prostaglandin-induced luteal regression. animals given hcg (n = 12) ovulated within a 2-day period (days 9 and 10 after prostaglandin) compared with a 4-day period (days 9 to 12) in the control group (n = 12). the mean interval to ovulation was similar in both groups. there was no difference in the timing of the preovulatory estradiol (e ...	1987	3475217
elevated urinary excretion of beta-aminoisobutyric acid and exposure to inorganic lead.	beta-aminoisobutyric acid (beta-aib), a normal degradation product of thymine, a constituent of dna and, to a lesser extent, of transfer rna, is excreted in low levels in human urine. we found that a group of iron workers occupationally exposed to inorganic lead excreted high levels of urinary beta-aib. elevated urinary excretion of beta-aib was also observed in marmosets, callithrix jacchus, that received lead acetate in drinking water. our results suggest that increased urinary excretion of be ...	1987	3579372
fetal brain development in response to iodine deficiency in a primate model (callithrix jacchus jacchus).	the common cotton-eared marmoset (callithrix jacchus jacchus) has been used for the first time as a primate model to study the effects of dietary iodine deficiency on fetal brain development. paired male and female marmosets were fed a low-iodine diet of maize, peas, meat meal, torula yeast, maize oil and added vitamins, minerals and amino acids for 6 months before mating. offspring from first and second pregnancies were compared with offspring from control marmosets fed the same diet but supple ...	1987	3612176
radionuclide angiographic study of the influence of dietary lipid supplements on cardiac function in the marmoset (callithrix jacchus).	radionuclide angiography was used to examine the influence of dietary fat on cardiac function in the common marmoset monkey (callithrix jacchus jacchus) under barbiturate anaesthesia. animals were fed for 6-8 months with a low fat (4.5%) reference diet or the same diet supplemented (12%) with sunflower seed oil or sheep fat. although there was a tendency towards increased heart rate, left ventricular ejection fraction, peak ejection rate, and peak filling rate in both fat supplemented groups, si ...	1987	3652103
animal models of mycoplasma genitalium urogenital infection.	male and female animals were inoculated urogenitally with mycoplasma genitalium, recovered originally from men with nongonococcal urethritis. mice, hamsters and male rhesus monkeys (macaca mulatta) were resistant. male cynomolgus monkeys (macaca fascicularis) were not as sensitive as male chimpanzees (pan troglodytes): 9 of 11 developed an obvious genital tract infection, some shedding organisms for more than 18 weeks. m. genitalium was recovered from the blood of two of them when large numbers ...	1987	3667225
distribution of motoneurones innervating extraocular muscles in the brain of the marmoset (callithrix jacchus).	extraocular muscle motoneurones were localised in the oculomotor nucleus (on), trochlear nucleus (tn) and abducens nucleus (an) in the marmoset brain using the horseradish peroxidase (hrp) retrograde labelling technique. hrp pellets injected into individual extraocular muscles revealed one or more groups of labelled neurones occupying discrete loci within these nuclei. relatively little overlap of motoneurone pools was observed, except in the case of the inferior oblique and superior rectus musc ...	1987	3142199
persistence of the pars externa system of the anterior olfactory nucleus in a microsmatic primate, callithrix jacchus.	the pars externa (pe) system of the anterior olfactory nucleus (aon) in a primate, callithrix jacchus, was defined by its architecture and by its connection patterns with the main olfactory bulb (mob) as revealed by tracing techniques. focal, unilateral injections of wheat germ agglutinin-conjugated horseradish peroxidase into the mob yielded ipsilaterally labelled afferent neurons in all subdivisions of the aon, with the exception of a clearly circumscribed area in the ventrolateral retrobulbar ...	1988	2458800
fate of recombinant human renin administered exogenously to anesthetized monkeys.	highly purified recombinant human renin (rh-renin), synthesized by chinese hamster ovary cells, was labeled with iodine-125 and was given intravenously to pentobarbital-anesthetized common marmosets (callithrix jacchus) to study the fate of the circulating renin. specific anti-rh-renin antiserum was used to identify the 125i-rh-renin. plasma disappearance of the exogenously administered 125i-rh-renin in marmosets (n = 6) showed two exponential components, with a half-life of 12.1 +/- 1.9 minutes ...	1988	3049339
herpesvirus ateles immortalizes in vitro a cd3+cd4+cd8+ marmoset lymphocyte with nk function.	herpesvirus ateles, nonpathogenic in its natural host, the spider monkey, induces a fatal lymphoproliferative syndrome in a variety of new world primate species. whereas the closely related new world primate virus herpesvirus saimiri immortalizes in vitro common marmoset lymphocytes that express a tcr and phenotypically are cd4-cd8+nkh1+, we now show that h. ateles-immortalized marmoset lymphocytes are cd3+ and cd4+. furthermore, these cd4+ lymphocytes coexpress cd8 and nkh1. the nk function of ...	1988	2828471
long-term protection against argentine hemorrhagic fever in tacaribe virus infected marmosets: virologic and histopathologic findings.	tacaribe virus may represent a better alternative than attenuated strains of junin virus (jv) for immunization against argentine hemorrhagic fever (ahf) because of possible risk of persistent infection of disease associated with live, attenuated strains. callithrix jacchus marmosets, which suffer 100% mortality if inoculated with the pathogenic xj strain of jv, were used to evaluate possible tacaribe virus persistence, subclinical, or long-term disease and the duration of protection against chal ...	1988	2832541
expression of c-type viral particles at implantation in the marmoset monkey.	type c rna retroviral particles have been observed budding from the plasma membrane of syncytiotrophoblast during a study of embryo implantation in the common marmoset (callithrix jacchus). these viral particles appear in profusion at the interface of syncytiotrophoblast with cytotrophoblast. they appear to be a non-infective, endogenous viral component of the host genome, although the precise role of the c-type virus in this context is unclear at present. such viral particles have been reported ...	1988	2836475
glomerulonephritis in common marmosets infected with plasmodium brasilianum and epstein-barr virus.	plasmodium brasilianum causes chronic quartan malaria in the common marmoset callithrix jacchus, whereas epstein-barr virus (ebv) infection is followed by an infectious mononucleosis-like syndrome that resolves. we infected weanling marmosets with one or both of these pathogens. timing of the infections influenced outcome. six animals were simultaneously infected with both agents; four became seriously ill (with accompanying proteinuria and edema) and either died or were killed. histopathology i ...	1988	2844917
tissue activities of enzymes of diagnostic interest in the marmoset and rat.	the activities of enzymes of diagnostic interest were investigated in the liver, heart, kidney and muscle of the marmoset (callithrix jacchus) and the rat. methods of tissue extraction which gave maximal enzyme activity were used and comparison between the species showed some major differences. ast, ldh and gdh showed a similar distribution in both species but icdh activity was much higher in the rat heart than in any other rat or marmoset organ. alp, lap and ggt were present in much higher acti ...	1988	2905366
chronic toxicity of 3,4,3',4'-tetrachlorobiphenyl in the marmoset monkey (callithrix jacchus).	cotton top marmoset monkeys (callithrix jacchus) were orally dosed with 3, 1, 0.1 or 0 mg 3,4,3',4'-tetrachlorobiphenyl (tcb)/kg body weight twice per week for 18-23 weeks. severe toxicity occurred in the highest dose group. clinical signs of toxicity were a rapid decrease in body weight, alopecia, abnormal nail growth, nodular enlargement of the nipple area and scaly skin. haematological analysis of peripheral blood revealed mild leukocytosis and anemia. biochemical alterations observed were el ...	1988	3124295
connections of the primary auditory cortex in the common marmoset, callithrix jacchus jacchus.	the afferent and efferent connections of the primary auditory cortex (ai) of common marmosets were traced following small injections of wheat germ agglutinin conjugated with horseradish peroxidase (wga-hrp) made at best frequency (bf)-defined sites in the ai. after the injections the animals remained anesthetized for 15-23 hours; they were then perfused transcardially with fixative and the brains were processed for wga-hrp reaction product. examination of the disposition of labelled material rev ...	1988	3128585
induction of luteal regression in the marmoset monkey (callithrix jacchus) by a gonadotrophin-releasing hormone antagonist and the effects on subsequent follicular development.	doses of 100 or 200 micrograms of a novel gnrh antagonist ([n-acetyl-d beta na11-d-pcl-phe2-d-phe3-d-arg6-phe7-arg8-d-ala10]nh2 gnrh) (4 animals/dose) were administered on days 10/11 of the luteal phase and induced a marked suppression of circulating bioactive lh and progesterone concentrations within 1 day of treatment (p less than 0.01). thereafter, progesterone concentrations remained low or undetectable until after the next ovulation. similar results were obtained when 200 micrograms antagon ...	1988	3129559
identification of the main gestagen metabolite in marmoset (callithrix jacchus) urine by nmr and ms spectroscopy.	hydroxypregnanolone is the most abundant progesterone metabolite in the urine of marmoset monkeys (callithrix jacchus). the substance is excreted as conjugate. the concentration of this steroid may be monitored by high performance, thin layer chromatography and postchromatographic derivatization. hydroxypregnanolone was purified and subsequently identified by nmr spectroscopy and gas chromatography/mass spectroscopy. the exact chemical structure is 5 alpha-pregnane-3 alpha, 7 alpha-diol-20-one.	1988	3130485
factors influencing follicle-stimulating hormone-responsive steroidogenesis in marmoset granulosa cells: effects of androgens and the stage of follicular maturity.	preovulatory changes in the steroidogenic function of primate granulosa cells were studied using the cyclic marmoset (callithrix jacchus) as a model. antral follicles (greater than or equal to 0.5 mm diameter) were dissected from mid-late follicular phase ovaries (7 days after prostaglandin-induced luteolysis) and classified by diameter as small (0.5-1.0 mm), medium (1.1-1.9 mm) or large (greater than or equal to 2.0 mm). granulosa cells from follicles in each size category were isolated and poo ...	1988	3131124
plasmodium vivax malaria in the common marmoset, callithrix jacchus: adaptation and host response to infection.	infection with plasmodium vivax was established in splenectomized callithrix jacchus marmosets by inoculation of parasitized blood from aotus trivirgatus carrying the vietnam palo-alto line of p. vivax. subsequent blood passage through intact marmosets resulted in higher peak parasitaemias (about 1% of red cells infected) and the loss of stainable schüffner's dots in infected cells. primary infections with the adapted line were patent for 74 days or more, and induced both a substantial antibody ...	1988	3131721
characterization of colonic cellular glycoconjugates in colitis and cancer-prone tamarins versus colitis and cancer-resistant primates.	differences in colonic secretory glycoconjugates (ie, mucin) between normal and ulcerative colitis-prone patients have been noted. similar differences may occur in a corresponding primate model, the cotton-top tamarin (ctt), saguinus oedipus, a new world monkey which suffers from spontaneous chronic colitis and colon cancer. lectin reagents were used to characterize and compare colonic cell surface, cytoplasmic, and secretory glycoconjugates of 9 clinically healthy cotton-top tamarins, 7 colitis ...	1988	3132857
cellular aspects of pre-ovulatory folliculogenesis in primate ovaries.	according to current concepts of pre-ovulatory folliculogenesis in primate ovaries, each growing follicle has a 'threshold' requirement for stimulation by fsh which must be met if it is to enter the oestrogen-secretory phase of pre-ovulatory development. until recently, our understanding of the intra-follicular mechanisms underlying fsh action on granulosa cells was based largely on information from non-primate laboratory animals, mainly polyovulators such as rats. the present paper describes st ...	1988	3134394
social status controls lh secretion and ovulation in female marmoset monkeys (callithrix jacchus).	the suppression of ovulation in subordinate female marmosets was associated with suppressed pituitary lh secretion and reduced pituitary lh response to gonadotrophin-releasing hormone (gnrh). in subordinate females, basal plasma lh concentrations were commonly below 2 iu/l (n = 5) (maximum 10.7 iu/l). plasma oestrogen concentrations were similarly low (maximum 0.62 nmol/l) and plasma progesterone concentrations of below 30 nmol/l confirmed the anovulatory condition. this infertility condition wa ...	1988	3134506
births following the transfer of cultured embryos obtained by in vitro and in vivo fertilization in the marmoset monkey (callithrix jacchus).	the aim of this study was to determine whether marmoset monkeys are a suitable primate model for in vitro fertilization (ivf), embryo culture, and transplantation studies. a prostaglandin analogue given in early pregnancy and human chorionic gonadotropin given near the end of the ensuing follicular phase were used for controlling the reproductive cycle, timing oocyte collection, and synchronizing the cycles of oocyte donors and embryo recipients. five embryos obtained by ivf were transferred at ...	1988	3137105
polymorphism of visual pigments in a callitrichid monkey.	microspectrophotometric measurements of visual pigments have been obtained for a large sample of new world monkeys of the species callithrix jacchus jacchus. these animals exhibit a polymorphism of visual pigments. the rods (lmax 499 nm) and the short-wave receptors (lmax 423 nm) appear to be common to all animals but individuals differ in the number and spectral position of pigments in the green-yellow spectral region. the latter pigments cluster near 545, 559 and 567 nm. male monkeys draw one ...	1988	3143179
the enantiomers of the teratogenic thalidomide analogue em 12: 1. chiral inversion and plasma pharmacokinetics in the marmoset monkey.	the plasma pharmacokinetics of the enantiomers of 2-(2,6-dioxopiperidine-3-yl)-phthalimidine (em 12) and the racemic mixture of this substance were investigated in callithrix jacchus, a thalidomide-sensitive primate. single doses of 5 mg/kg body wt were administered orally or intraperitoneally. maximum plasma concentrations were reached 1 h after administration of the enantiomers, and 3 h after application of the racemate. the mean plasma elimination half-life was in the range of 5 h for the ena ...	1988	3143339
effects of hypothalamic lesions upon the sexual and social behaviour of the male common marmoset (callithrix jacchus).	the sexual and associated behaviour of 10 adult male marmosets was recorded during pair tests with ovariectomized females, before and after bilateral thermal lesions of the hypothalamus. four sham-lesioned males served as controls. lesions varied in volume from 1.49 to 3.28 mm3 and extended from the ventromedial hypothalamus to the diagonal band of broca. precopulatory behaviours (anticipatory erections, tongue flicking and anogenital investigations of the female) as well as frequencies of mount ...	1988	3143470
embryotoxic effects of thalidomide derivatives on the non-human primate callithrix jacchus; 3. teratogenic potency of the em 12 enantiomers.	the teratogenic potencies of the enantiomers of 2-(2,6-dioxopiperidine-3-yl)-phthalimidine ( = em 12), a teratogenic thalidomide analogue, were investigated in callithrix jacchus, a primate very sensitive to the teratogenic action of this thalidomide analogue. the results indicate that the s-(-)-form of em 12 is clearly more teratogenic than the r-(+)-form. the interpretation of the studies designed to evaluate stereo-selective differences in the teratogenicity of the enantiomers becomes difficu ...	1988	3196154
embryotoxic effects of thalidomide-derivatives in the non-human primate callithrix jacchus. i. effects of 3-(1,3-dihydro-1-oxo-2h-isoindol-2-yl)-2,6-dioxopiperidine (em12) on skeletal development.	the response of pregnant marmosets (callithrix jacchus) to the thalidomide derivative em 12 was evaluated. em 12 was selected for these studies because it is more active than thalidomide and is much more stable for hydrolysis. skeletal gross structural abnormalities were observed when em 12 was given to marmosets for 3-7 days during the period between days 49 and 60 post ovulation. using the treatment schedule finally adapted in our laboratory, i.e. treatment during days 51-57 post ovulation, do ...	1988	3355362
embryotoxic effects of thalidomide derivatives in the non-human primate callithrix jacchus. ii. elucidation of the susceptible period and of the variability of embryonic stages.	data are presented on the normal intra- and inter-litter variability of the embryonic stages in the common marmoset (callithrix jacchus) on day 56 of pregnancy. the embryology of the marmoset is described with respect to the susceptible period for the teratogenic action of thalidomide.	1988	3355363
the d1 agonist skf 38393 inhibits the antiparkinsonian activity of the d2 agonist ly 171555 in the mptp-treated marmoset.	administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) to common marmosets induced persistent motor deficits. administration of the d1 agonist skf 38393 (2.5-20 mg/kg, i.p.) caused a dose-dependent increase of this akinesia. administration of the d2 agonist ly 171555 (0.3 mg/kg, i.p.) reversed the motor deficits induced by mptp treatment. pretreatment of animals with skf 38393 (2.5-20 mg/kg, i.p.) caused dose-dependent inhibition of the anti-parkinsonian action of ly 171555 (0.3 m ...	1988	2907373
the d-1 dopamine receptor partial agonist, cy 208-243, exhibits antiparkinsonian activity in the mptp-treated marmoset.	administration of l-dopa plus carbidopa, or the d-2 agonist (+)-phno, to mptp-treated common marmosets caused motor hyperactivity and a reversal of the parkinsonian syndrome. in contrast, administration of the putative d-1 agonist skf 38393 was without effect on movement or motor disability. the subsequent administration of another putative selective d-1 partial agonist cy 208-243 produced a dose-related improvement in motor activity and reversal of parkinsonian motor deficits in mptp-treated an ...	1988	2977118
coprophagy in marmosets due to insufficient protein (amino acid) intake.	in the course of experiments to study the minimal protein requirement of common marmosets by nitrogen balance methods, coprophagy was observed. it occurred in most animals fed diets either with a protein content below 6% or lacking histidine/arginine. the protein level of 6% had previously been evaluated as being the minimal protein requirement for maintenance of marmosets.	1988	3148060
levels of met-enkephalin, leu-enkephalin, substance p and cholecystokinin in the brain of the common marmoset following long term 1-methyl-4-phenyl-1,2,3,6,-tetrahydropyridine treatment.	common marmosets were treated daily with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp, 7-9 mg/kg i.p.) for 25 days, and then kept out of drug for three months before biochemical measurements in various brain areas. this treatment induced a dramatic fall (-80%) in dopamine, homovanillic acid and dihydroxyphenylacetic acid levels in the putamen and caudate nucleus, and a significant but less pronounced reduction (less than or equal to 50%) in the levels of these compounds in the nucleus accu ...	1988	2468106
effects of acute stress on the patterns of lh secretion in the common marmoset (callithrix jacchus).	stressful stimuli associated with aggressive encounters and low social rank may affect female fertility in a variety of mammalian species. in these experiments we examined the effects of aggressive encounters and physical restraint in a primate chair on the patterns of lh secretion in ovariectomized, oestrogen-primed female marmosets. receipt of aggression from a female conspecific, followed by physical restraint for collection of blood samples (at 10-min intervals for 4 h), resulted in marked d ...	1988	3139816
effect of various biological factors on spontaneous marmoset and tamarin colitis. a retrospective histopathologic study.	histological sections of colons from 69 tamarins (46 saguinus oedipus and 23 saguinus fuscicollis illigeri) and 27 marmosets (callithrix jacchus) that died between 1979 and 1984 were examined for colitis. evaluated biological factors were species, age at death, source of animals, manner of death, presence of colon cancer, and time after importation. most normal colons were found in young animals (dead at less than 1 years of age). nearly all (approximately 96%) animals had colitis; 70-80% of mos ...	1988	3134175
distribution and some projections of cholinergic neurons in the brain of the common marmoset, callithrix jacchus.	the distribution of choline acetyltransferase-immunoreactive (chat-ir) neurons was studied in the brain of the common marmoset by using immunohistochemistry. chat-ir neurons were found in the medial septal nucleus, vertical and horizontal limb nuclei of the diagonal band, the nucleus basalis of meynert, pedunculopontine nucleus and laterodorsal tegmental nucleus, and also in the striatum, habenula, and brainstem cranial nerve motor nuclei. the organization of chat-ir neurons in the basal forebra ...	1988	2454972
a restraint system for the common marmoset (callithrix jacchus).	a method for restraining the marmoset in a primate chair is described. the device is inexpensive to construct, is reliable, and the majority of animals can be habituated to its use. the chair has been used in neurobiological studies employing electrophysiological recordings, with or without concurrent collection of serial blood samples.	1988	3134573
effect of antiprogestin zk 98.734 on the ovarian cycle, early pregnancy, and on its binding to progesterone receptors in the myometrium of marmoset callithrix jacchus.	the antiprogestin zk 98.734 (11 beta-(4-dimethylaminophenyl-17 beta-hydroxy-17 alpha-(3-hydroxy-prop-1(z)-enyl-4,9(10)-estradien-3-one) was administered i.m. (5 mg/day) for three consecutive days to two groups of common marmosets. in one group (nonpregnant, n = 6), it was injected during the luteal phase, and to the second group (pregnant, n = 7), it was injected during early pregnancy, on days 24-26 of the mid-cycle estradiol peak. administration of zk 98.734 during the luteal phase caused a sh ...	1988	3132210
endogenous n-excretion and minimal protein requirement for maintenance of the common marmoset (callithrix jacchus).	the protein requirement for maintenance of the marmoset callithrix jacchus was investigated by factorial calculation via the n balance technique. six adult male marmosets were fed a protein-free pelleted diet for 22 days. when a low protein diet (6%) was fed in the preperiod, only 7 days were necessary and when fed a higher protein diet (18%) 10 days were necessary to reach a minimum of n excretion during protein depletion. body weight losses averaged 11% and food intake was 21% lower in the pro ...	1988	3131585
postnatal development of dendrites of relay neurons in the lateral geniculate nucleus of the marmoset (callithrix jacchus): a quantitative golgi study.	dendrites of multipolar relay neurons in the lateral geniculate nucleus of the marmoset (callithrix jacchus), at various ages from birth to adulthood, were studied in rapid golgi preparations. the dendrites were analyzed by means of three-dimensional computer reconstructions and decomposed into intermediate and terminal segments, both of which were further classified according to their centrifugal order. measurements were made of the number of segments per dendrite, the total length of dendrites ...	1988	3129457
effect of iodine deficiency on craniofacial growth in young common marmosets (callithrix jacchus).	the effects of iodine deficiency on general and craniofacial growth were determined in young common marmosets. examinations, including direct measurement, cephalometric radiology, and dental examination, were performed at three-month intervals from birth to 1 year on a cross-sectional sample of three groups of marmosets. the groups were those on a normal diet, n = 50; an iodine-deficient diet during gestation and for 1 year postnatally, n = 26; and an iodine-deficient diet only during gestation ...	1988	3209685
evaluation of seven test kits for the detection of pregnancies in the common marmoset, callithrix jacchus.		1988	3151193
dna 'fingerprinting' of captive family groups of common marmosets (callithrix jacchus).		1988	3150839
the parasite trichospirura leptostoma associated with wasting disease in a colony of common marmosets, callithrix jacchus.		1988	3150838
effects of dorsal penile nerve transection upon the sexual behaviour of the male marmoset (callithrix jacchus).	the sexual behaviour of 7 adult male marmosets and their ovariectomized partners was observed during pair-tests before and after bilateral dorsal penile nerve transection (n = 4) or a sham operation (n = 3). after transection of the dorsal penile nerves, males mounted more frequently and the initial mount of each test was more prolonged. males continued to orientate correctly during mounts and to make rapid pelvic thrusts, with the erect penis close to the vaginal orifice. however, the deep pelv ...	1988	3145513
embryonic signals during the peri-implantation period in primates.	during the peri-implantation period of pregnancy in primates, chorionic gonadotrophin (cg) is the first clear signal of the embryo's presence and viability. in the marmoset (callithrix jacchus) implantation begins on day 11-12 after ovulation and cg is secreted by the embryo from this time. the inner cell mass is necessary for the normal secretion of cg by the trophoblast. implantation can be disrupted both in vivo and in vitro by antisera to the hcg-beta subunit. the secretion of a platelet act ...	1988	3142993
chromosome studies of saguinus midas niger (callithricidae, primates) from tucurui, para, brazil: comparison with the karyotype of callithrix jacchus.	the karotype of saguinus midas niger was studied by g-, c-, and nuclear organizer region (nor)-banding techniques. variations in c-banding patterns were observed in some chromosomes. the banding patterns obtained were compared with those previously described for callithrix jacchus. the two species differ by a reciprocal translocation involving pairs 9 and 16; by a paracentric inversion in chromosomes 1, 13, 14, 18, and 22; and by a pericentric inversion in at least four subtelocentric pairs (chr ...	1988	31973446
circadian pattern of plasma melatonin concentrations in the marmoset monkey (callithrix jacchus).	this study describes the concentrations of melatonin in plasma samples taken from marmoset monkeys (callithrix jacchus) every 4 h over three 24-h periods. a circadian pattern of secretion was apparent, with higher levels recorded at night (20.00-08.00 h) than during the day (08.00-20.00 h) and a peak concentration at 20.00 h. there was a significant difference in the mean day and night concentrations (32.5 ± 4.5 pg/ml versus 49.0 ± 6.9 pg/ml, respectively) with individual concentrations ranging ...	1989	31968856
characteristics of the circadian activity rhythm in common marmosets (callithrix j. jacchus).	the circadian activity rhythm of the common marmoset, callithrix j. jacchus was investigated by long-term recording of the locomotor activity of 15 individuals (5 males, 10 females) from 1.5 to 8 years old, both under constant illumination and under ld 12:12. the mean period of the spontaneous circadian rhythm was 23.2 ± 0.3 h. neither sex-specific differences nor a systematic influence of light intensity on the spontaneous period were observed, but the period was dependent on the duration of th ...	1989	31964051
systems for collection of urine in the captive common marmoset, callithrix jacchus.	two systems are described for the collection of 24 h urine samples from the common marmoset (callithrix jacchus). using 84 adult animals, 1210 24-h samples were collected. mean urinary excretion was 14.4 +/- 7.5 ml/24 h (n = 1210, mean +/- sd). no differences were observed between sexes (for 52 females, 24 h volume = 15.1 +/- 8.0 ml; for 32 males, 24 h volume = 12.5 +/- 6.0 ml). no significant differences were observed between pregnant and non-pregnant females with respect to 24 h urine volume, ...	1989	2509801
connective tissue of the livers of newborn and adult marmosets (callithrix jacchus).	immunofluorescence microscopic and electron microscopic investigations revealed components of the matrix and of the basal lamina (collagen type i, iii, iv and v, bl-heparan sulfate and fibronectin) in the sinus wall (disse's space) of the livers of newborn and adult marmosets (callithrix jacchus). collagen type i was missing in both the two age groups. small amounts of laminin were present in the livers of newborn and absent in those of adult animals, whereas collagen type iii occurred in the fo ...	1989	2485198
distribution of phenolsulphotransferase and monoamine oxidase in the common marmoset.		1989	2502120
progesterone antagonist lilopristone: a potent abortifacient in the common marmoset.	the effects of a progesterone antagonist zk 98.734 (lilopristone) on implantation, early pregnancy, and midpregnancy were studied in the common marmoset, callithrix jacchus jacchus. treatment (5 mg/da intramuscularly for 3 consecutive days) on day (n = 8) after the midcycle peak in estradiol levels in mated animals induced a premature drop in plasma progesterone levels and shortened the ovarian cycle length. treatment on day 20 (n = 5) or day 40 (n = 5) induced a drop in progesterone levels and ...	1989	2502015
the protein requirement of adult marmosets: nitrogen balances and net protein utilization of milk proteins, soy protein, and amino acid mixtures.	nitrogen balance studies were conducted in adult male marmosets (callithrix jacchus) using purified and semipurified diets with protein levels between 0% and 7%. daily nitrogen loss in a state of prolonged protein free nutrition was 131 +/- 16 mg/kg body weight0.75. zero nitrogen balance resulted from mean daily intake of 261 mg nitrogen/kg0.75 when high quality protein sources were used. very low protein intake or the lack of arginine and histidine in an amino acid mixture induced coprophagy. i ...	1989	2503946
effects of male partners upon proceptivity in ovariectomized estradiol-treated marmosets (callithrix jacchus).	effects of male partners upon the expression of female proceptivity were examined in two experiments using 16 ovariectomized marmosets. experiment 1 showed that the female's proceptive tongue-flicking display (ptf) is triggered specifically by eye contact with the male. stimulation of ptf by administration of estradiol-17 beta (e2) to ovariectomized females depends in part upon the male's responsiveness to female displays, such as "staring" and "freezing," which may serve to attract his attentio ...	1989	2501211
naloxone reversal of stress-induced suppression of lh release in the common marmoset.	there is considerable evidence suggesting that endogenous opioid peptides (eop) might play a role in the defensive response to stressful stimuli. the stress associated with receipt of aggression from a female conspecific and physical restraint for collection of serial blood samples (at 10-min intervals) resulted in a significant (p less than 0.05) suppression of lh secretion in the oestradiol primed ovariectomized marmoset. administration of the opioid receptor antagonist, naloxone (1 mg/kg) imm ...	1989	2780870
the diagnostic usefulness of isocitrate dehydrogenase (icdh) in the marmoset (callithrix jacchus).	marmosets were given either a hepatotoxin, carbon tetrachloride, orally or an i.m. injection of a mytoxin, chlorpromazine. although muscle damage alone caused small increases in the plasma levels of lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase and isocitrate dehydrogenase (icdh), only the isoenzyme analysis of icdh can differentiate definitely between liver and muscle damage. only very severe muscle damage can increase the plasma concentration of this enzyme but, i ...	1989	2494250
description of eight phases of spermiogenesis in the marmoset testis.	the differentiation of spermatids in the marmoset (callithrix jacchus, n = 9) testis is described here at the light-microscopic level employing serial semithin sections. the definition of 8 different phases of spermiogenesis, i.e. the formation of spermatids, is based upon the changes in the development of nucleus, acrosome and flagellum.	1989	2501964
the evolution and distribution of morphological changes in the nervous system of the common marmoset following the acute administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.	six young adult marmosets received 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in multiple doses (total 8-16 mg/kg over 2-13 days) sufficient to produce a parkinsonian syndrome and were killed up to 3.5 months later. cellular changes were found in the substantia nigra, ventral tegmental area, and hypothalamus. the earliest histological abnormalities were axonal swellings in proximal parts of nigrostriatal axons. subsequent changes in the substantia nigra were reduced nissl staining, reduced cel ...	1989	2494438
splitting of the circadian activity rhythm in common marmosets (callithrix j. jacchus; primates).	long-term recordings of the free-running circadian activity rhythm in common marmosets, callithrix j. jacchus, living under constant environmental conditions (ll 200-470 lx) provided evidence of rhythm splitting in nonhuman primates. in two out of ten test animals two different types of splitting occurred; spontaneous persistent splitting and temporary splitting. neither a reduction of the illumination intensity nor the application of dark pulses had any effect on the two activity components of ...	1989	2513221
learning about rules but not about reward is impaired following lesions of the cholinergic projection to the hippocampus.	common marmosets with bilateral ibotenic acid-induced destruction of the neurones of the vertical limb of the diagonal band of broca, which provide the major cholinergic input to the hippocampal formation, were impaired on the acquisition but not on the retention of a repeated-trial visuospatial discrimination learning task. they were also impaired on serial spatial reversal learning (but not on serial object reversal learning), on acquisition of a trial-independent successive concurrent discrim ...	1989	2510907
transient depletion of nucleus accumbens dopamine content may contribute to initial akinesia induced by mptp in common marmosets.	acute treatment of common marmosets with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) caused an initial profound akinesia and other motor deficits. however, over the following months akinesia gradually disappeared although the animals remained clumsy and poorly coordinated. at 10 days following mptp treatment there was a profound decrease in the dopamine, hva and dopac content of the caudate nucleus, putamen and nucleus accumbens. by 3-4 months following mptp treatment the animals had lar ...	1989	2597167
treatment with a selective mao b inhibitor prevents loss of dopamine in the nucleus accumbens of mptp-treated common marmosets.	administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) to common marmosets induced motor deficits, associated with a marked decrease in the uptake of [3h]dopamine into synaptosomes in the putamen and a reduction in the content of dopamine in both caudate nucleus and nucleus accumbens. histological analysis showed a marked loss of dopamine-containing cells in the zona compacta of the substantia nigra and less loss in the ventral tegmental area. treatment of animals with the selecti ...	1989	2512516
further treatment with mptp does not produce parkinsonism in marmosets showing behavioural recovery from motor deficits induced by an earlier exposure to the toxin.	1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), or 0.9% saline, was administered to a group of common marmosets initially treated with the toxin 12-18 months previously. initial treatment had consisted of a cumulative dose of 6-22 mg/kg (i.p.) which caused marked parkinsonism. subsequently, the animals gradually recovered normal motor function. further treatment consisted of a cumulative dose of mptp of 78-83 mg/kg (i.p.) but this produced only modest akinesia. at 12-18 months after the ini ...	1989	2510050
increased caudate dopamine turnover may contribute to the recovery of motor function in marmosets treated with the dopaminergic neurotoxin mptp.	administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) to common marmosets initially impaired motor function, but a partial recovery occurred over the following weeks. at both 10 days and 4-6 weeks following mptp treatment, [3h]dopamine ([3h]da) uptake into synaptosomal preparations of putamen was markedly decreased. at 10 days and 4-6 weeks following mptp treatment da, homovanillic acid (hva) and 3,4-dihydroxyphenylacetic acid (dopac) levels in the caudate nucleus and nucleus acc ...	1989	2505199
loss of ocular dominance columns with maturity in the monkey, callithrix jacchus.	previous studies have shown that adult marmosets lack ocular dominance columns (odc) in area 17, but that odcs can be demonstrated upon visual deprivation. the present results, obtained by transneuronal transport of wga-hrp, indicate that odcs normally develop in juvenile marmosets but disappear before the animal reaches maturity. the findings suggest that formation of odcs during ontogenesis, and their persistence through adulthood, are different developmental processes depending on different m ...	1989	2472851
differences in transneuronal transport of horseradish peroxidase conjugated wheat germ agglutinin in the visual system: marmoset monkey and guinea pig compared.	conjugates of the lectin wheat germ agglutinin with horseradish peroxidase have been described as effective transneuronal tracers in different neuronal systems of various mammalian species. here, the failure is described to detect any sign of transneuronal transport of the tracer in the visual system of adult marmoset monkeys (callithrix jacchus), in spite of heavy anterograde labeling in the primary visual centers after intravitreous injections. in contrast, in the brains of guinea pigs process ...	1989	2473107
comparison of the metabolism and disposition of [3-14c]coumarin in the rat and marmoset (callithrix jacchus).	male sprague-dawley rats and marmosets were given a single oral 25 mg/kg dose of [3-14c]coumarin and the excretion of radioactivity in the expired air, urine and faeces monitored up to 96 h. excretion profiles were similar in both species with the bulk of the dose being excreted in the urine and faeces within 24 h. chromatographic analysis of 0-48 h urine samples revealed similar metabolic profiles with only small amounts of unchanged coumarin and very little 7-hydroxycoumarin. coumarin 7-hydrox ...	1989	2493171
developmental changes in luteinizing hormone/human chorionic gonadotropin steroidogenic responsiveness in marmoset granulosa cells: effects of follicle-stimulating hormone and androgens.	factors regulating lh/hcg responsiveness in primate granulosa cells were examined in the marmoset monkey (callithrix jacchus). granulosa cells were isolated and pooled from small antral (0.5-1.0 mm) and large preovulatory (greater than or equal to 2 mm) follicles from mid- to late follicular phase ovaries of cyclic marmosets. the cells from small and large follicles were cultured in serum-free medium for 48 h in the absence or presence of increasing concentrations of hcg (0.1-100 ng/ml) with or ...	1989	2494036
ascorbic acid in a new world monkey family: species difference and influence of stressors on ascorbic acid metabolism.	like other simian primates, the new world monkey callithrix jacchus, marmoset, and saguinus fuscicollis, tamarin, require ascorbic acid as an essential nutrient. for adult marmosets, a daily intake of 15 mg/kg metabolic body weight was found to be necessary to obtain a serum level above the kidney threshold. a survey of the serum ascorbic acid level of marmosets and tamarins in a breeding colony resulted in a vast divergence between the two species, indicating a higher ascorbic acid requirement ...	1989	2497592
heinz bodies do not modify the membrane characteristics of common marmoset (callithrix jacchus) erythrocytes.	the possibility was examined that the membrane function of erythrocytes obtained from healthy common marmosets (callithrix jacchus) was modified by the presence in the cells of heinz bodies. no significant differences were found in erythrocyte endogenous free malonyl dialdehyde (mda) or reduced glutathione (gsh) between normal human erythrocytes and marmoset erythrocytes containing heinz bodies. membrane fluorescent chromolipids, surface charge and thiol levels were similar in both species but a ...	1989	2498578
comparative studies on nafenopin-induced hepatic peroxisome proliferation in the rat, syrian hamster, guinea pig, and marmoset.	nafenopin was administered orally for 21 days to male sprague-dawley rats (0.5-50 mg/kg/day), syrian hamsters (5-250 mg/kg/day), dunkin-hartley guinea pigs (50 and 250 mg/kg/day), and marmosets (callithrix jacchus, 50 and 250 mg/kg/day). with the rat, and to a lesser extent in the hamster, nafenopin treatment produced dose-related increases in liver size and induction of peroxisomal (palmitoyl-coa oxidation) and microsomal (lauric acid 12-hydroxylase) fatty acid oxidizing enzyme activities. in c ...	1989	2499080
experimental brugia pahangi and b. malayi infections of callitrichid primates.	the callitrichid primates, callithrix jacchus jacchus (the marmoset) and saguinus labiatus (the tamarin) were inoculated with infective larvae of brugia malayi and b. pahangi. microfilaraemia at low levels developed in 3 out of 4 c.j. jacchus infected with b. malayi and living or dead adult worms found in all 4. only one of 4 c.j. jacchus became microfilaraemic (mf + ve) when given b. pahangi and adults were found in two. of 4 s. labiatus given b. pahangi one became very lightly mf + ve and adul ...	1989	2500478
termination of pregnancy in common marmosets (callithrix jacchus) following administration of antiserum to chicken riboflavin carrier protein.	the presence of protein(s) which is immunologically and functionally similar to the well characterised avian riboflavin carrier protein has been demonstrated in female common marmosets during pregnancy. the protein(s) that interacts with [14c]riboflavin has an immunological homology to chicken riboflavin carrier protein. the termination of pregnancy in four out of six marmosets following administration of antiserum to chicken riboflavin carrier protein supports the hypothesis that vitamin carrie ...	1989	2503615
inoculation of new world primates with the human immunodeficiency virus.	the susceptibility of common marmosets and cotton-top tamarins to infection by hiv-2 in vivo was tested. one year and 19 months, respectively, post-inoculation, sera taken from three of four animals from each species are reactive for hiv-2 antibodies and hiv-specific nucleotide sequences were demonstrated in short-term cultures of pbl from two cotton-top tamarins. the animals remain in good health.	1989	2503618
a re-investigation of the behavioural effects of intracerebral injection in marmosets of cytopathic cerebrospinal fluid from patients with schizophrenia or neurological disease.	in experiments designed to investigate transmission, cerebrospinal fluid (csf) from patients with schizophrenia or neurological disease (huntington's disease) which had been found to induce a cytopathic effect (cpe) in human embryonic fibroblast cell culture was injected intracerebrally into common marmosets. behavioural observations were made on the animals during a period of 2 1/2 years prior to injection and for 2 1/2 years after injection. in an earlier study (baker et al. 1983 b) we found t ...	1989	2503849
[ultrastructure of the gastrointestinal epithelium in the marmoset (callithrix jacchus)].	the epithelium of the stomach and intestine of one and three days old as well as adult marmosets was investigated using transmission electron microscopy and was compared with already existing data of man and the laboratory rodents, rat, mouse and guinea-pig. on postnatal day (pd) 1, the enterocytes possessed an inframicrovillous membrane system and giant lysosomes which were absent in adult marmosets whereas the surface and glandular epithelial cells of the stomach showed all structures which we ...	1989	2505460
luteal deficiency caused by human ovarian follicular fluid peptide in post-partum marmosets, callithrix jacchus.	a peptide purified from human ovarian follicular fluid (hoffp) was administered during the follicular phase of post-partum marmosets. four of the five animals treated with hoffp, ovulated as evidenced by the presence of ovarian stigmata at the time of laparotomy. however, only 2 of these animals became pregnant, one had a normal delivery while the other aborted. a shortening of the luteal phase was observed in the other three animals and all animals conceived in subsequent cycles. the results in ...	1989	2505968
shortening of luteal phase in common marmosets by sheep ovarian follicular fluid peptide.	a low molecular weight peptide has been partially purified from sheep follicular fluid. it inhibited fsh binding to granulosa cells from ovarian follicles of common marmosets (callithrix jacchus). when injected into cycling marmosets during the follicular phase, it reduced the area under the curve (auc) of circulating progesterone. the peptide also shortened the luteal phase in all marmosets during the treatment cycle compared to the pretreatment control cycle. these results indicate that the ov ...	1989	2505972
fall in coronary heart disease mortality in u.s.a. and australia due to sudden death: evidence for the role of polyunsaturated fat.	epidemiological studies have been reviewed which provide suggestive evidence of an association between the fall in coronary heart disease mortality in the u.s.a and australia since 1967, characterized by a fall in sudden deaths, to the increase in polyunsaturate fat consumption that has occurred in both countries since 1960. this association led directly in the same institution to carefully designed experimental studies undertaken in the rat, and a non-human primate, the marmoset (callithrix jac ...	1989	2506314
a new transmissible viral hepatitis of marmosets and tamarins.	callitrichid hepatitis (ch) is a newly recognized, acute, fatal, epizootic disease of new world primates in the family callitrichidae. since 1980, 12 outbreaks of ch have occurred in us zoos, involving several callitrichid species including the endangered golden lion tamarin (leontopithecus rosalia). ch was experimentally transmitted to common marmosets via a bacteria-free filtrate of liver from a naturally infected tamarin. all three inoculated marmosets developed an acute fatal disease with th ...	1989	2509570
control of inhibin production by primate granulosa cells.	in-vitro data from experiments on rats implicate granulosa cells as primary sites of hormone-dependent ovarian inhibin biosynthesis, but no equivalent data exist for primates. we have used the common marmoset (callithrix jacchus) to investigate inhibin biosynthesis in primate granulosa cells in vitro and to determine its relationship to preovulatory follicular development. to relate the production of immunoactive inhibin to follicular maturity, we studied primary granulosa cell cultures from fol ...	1989	2509620