Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| lymphoid tissue in the kidney of the musk shrew, suncus murinus. | we describe a lymphoid tissue in the kidney of the musk shrew, suncus murinus. an anatomically well organised lymphoid tissue, resembling the mucosa-associated lymphoid tissue, is associated with the epithelium of the renal pelvis and the ureter, respectively. lymphoid tissue distributed along the arcuate artery and arcuate vein is not structurally organised in centre and periphery. this tissue type is most prominently developed between blood vessels. immunocytochemistry revealed s-100-immunorea ... | 1995 | 7570577 |
| genetic variation and geographic distribution on the mitochondrial dna in local populations of the musk shrew, suncus murinus. | the musk shrew (suncus murinus) is widely distributed throughout asia and east africa. the mitochondrial dna (mtdna) of this species was analyzed in individuals from 31 local populations in nine asian countries and mauritius, using 17 restriction endonucleases. although fourteen and nine mtdna haplotypes were detected from bangladesh and nepal, respectively, one to four haplotypes were found in each southeast asian country, and one common haplotype existed in japan, philippines, vietnam, thailan ... | 1995 | 7632440 |
| immunocytochemical identification of serotonergic supraependymal nerve fibers in the third ventricle of the house musk shrew, suncus murinus. | supraependymal fibers of the house musk shrew (suncus murinus) were examined by conventional scanning electron microscopy (sem), backscattered electron (bse) imaging of enzyme immunohistochemistry and by immunotransmission electron microscopy in the dorsal part of the third ventricular wall. in this region, ependymal cells were not so heavily ciliated and conventional sem studies showed two main categories of supraependymal fibers. the first type consisted of long fibers fasciculated which were ... | 1995 | 7625602 |
| a novel dodecadepsipeptide, cereulide, is an emetic toxin of bacillus cereus. | a vacuole-formation substance, cereulide of bacillus cereus, is an emetic toxin in animals. both oral administration and intraperitoneal injection of cereulide caused dose-dependent emesis in suncus murinus, a new animal model of emesis. vagotomy or a 5-ht3 receptor antagonist completely abolished this emetic effect. therefore, cereulide causes emesis through the 5-ht3 receptor and stimulation of the vagus afferent. we also found that our purified cereulide caused swelling of mitochondria of hep ... | 1995 | 7781985 |
| evidence for the lack of hepatic n-acetyltransferase in suncus (suncus murinus). | the abilities of liver cytosol fractions from the suncus and sprague-dawley (sd) rats to n-acetylate aniline, p-aminobenzoic acid, p-aminosalicylic acid and 2-aminofluorene (af) were compared. the cytosol from rats n-acetylated these substrates at efficient rates, whereas the cytosol from the suncus did not n-acetylate these substrates at detectable rates. when af was given to the suncus, 2-acetylaminofluorene (aaf), a metabolite of af formed by n-acetyltransferase (nat), was not detectable in s ... | 1995 | 7488230 |
| collagen fibrils in the odontoblast layer in the teeth of the rat and the house shrew, suncus murinus, by scanning electron microscopy using a maceration method. | it is not well known whether there are gaps in the tight junctions between odontoblasts and whether the fluid flows from the pulp to the predentin through these gaps. the collagen fibrils in the odontoblast layer were investigated using a maceration method in order to show the existence of the gaps between tight junctions of the odontoblasts. the mandibles containing teeth of the rat and the house shrew were digested by naoh maceration and revealed the architecture of the collagen fibrils under ... | 1995 | 7554943 |
| characterization of a novel brain neutral glycosphingolipid composition in house musk shrew (suncus murinus). | glycosphingolipids were extracted from the brain of house musk shrew (suncus murinus). neutral glycosphingolipids were purified by qae-sephadex column chromatography followed by high-performance liquid chromatography using an iatrobeads column. purified glycosphingolipids were identified by high-performance thin-layer chromatography, carbohydrate analysis, fast-atom bombardment mass spectrometry and tlc immunostaining. the ganglioside pattern was almost the same as the pattern obtained for rat b ... | 1995 | 7601161 |
| distribution of chicken-ii gonadotropin-releasing hormone in mammalian brain. | brains of nonmammalian vertebrates typically contain multiple forms of gonadotropin-releasing hormone (gnrh). until recently, only the mammalian form of gnrh (mgnrh) had been isolated in placental mammals. biochemical and histological data show that both mgnrh and chicken-ii gnrh (cgnrh-ii) are present in a primitive placental mammal, the musk shrew (suncus murinus). similar to the case in nonmammalian species, in the musk shrew, neurons that express cgnrh-ii are located in a discrete cluster in ... | 1995 | 7673483 |
| the anti-emetic activity of gk-128 in suncus murinus. | in suncus murinus, various emetic responses and the anti-emetic activity of a new 5-hydroxytryptamine3 (5-ht3) receptor antagonist, gk-128 (2-[(2-methylimidazol-1-yl) methyl benzo[f]thiochromen-1-one monohydrochloride hemihydrate), were investigated. cancer chemotherapeutic agents, cisplatin and cyclophosphamide, dose-dependently induced emesis of long-lasting duration. the 5-ht3 receptor agonist, 2-methyl-5-ht, and copper sulfate also induced emesis of short duration. however, another 5-ht3 rec ... | 1995 | 8846809 |
| experimental models for carcinogenesis in the house musk shrew, suncus murinus, insectivora. | animal carcinogenicity studies have mainly been performed on rodents. from the phylogenetic point of view, animals closer to humans must be included in these studies. insectivora are considered to be the most primitive placental mammals and much closer to the early primates than rodents. among the insectivora, the house musk shrew (suncus murinus, family soracidae), has been bred under laboratory condition. this animal is small having a short life span, and a comparatively low incidence of spont ... | 1995 | 8573996 |
| the broad-spectrum anti-emetic activity of the novel non-peptide tachykinin nk1 receptor antagonist gr203040. | 1. following our earlier observations that the tachykinin nk1 receptor antagonist cp-99,994 is an effective anti-emetic in ferrets, we have examined the anti-emetic effects of a more potent and novel nk1 receptor antagonist, gr203040, against various emetic stimuli in the ferret, dog and house musk shrew (suncus murinus). 2. in ferrets, gr203040 (0.1 mg kg-1 s.c. or i.v.) is effective against emesis induced by radiation, cisplatin, cyclophosphamide, copper sulphate, ipecacuanha or morphine. 3. i ... | 1995 | 8719790 |
| distribution of taste buds on the epiglottis of the rat and house shrew, with special reference to air and food pathways. | we investigated the positioning of the epiglottis in the pharyngo-laryngeal region and the distribution of taste buds on the epiglottis in the rat and house shrew, animals which have different feeding habits. in the fixed samples of both species, when the mouth was closed or slightly opened, the epiglottis was found to protrude into the nasopharyngeal hiatus above the soft palate. but it retracted from its position when the mouth was widely opened. in omnivorous rats (n = 6), the mean number (me ... | 1995 | 8559556 |
| distribution of lectin binding in the testes of the musk shrew, suncus murinus. | distribution of lectin binding in the testis of the musk shrew, suncus murinus, was investigated by light and transmission electron microscopy. not only spermatogenic cells but also sertoli cells bound some lectins. canavalia ensiformis agglutinin (con a) and wheat germ agglutinin (wga, triticum vulgaris), indicating the presence of d-mannose and n-acetyl-d-glucosamine respectively, showed an intense reaction in the acrosomal region of early to late spermatids. ricinus communis agglutinin i (rca ... | 1995 | 7591995 |
| prevalence of rat fleas in and around delhi (india) area and their susceptibility status to insecticides. | a rapid survey in delhi and surrounding areas was undertaken in september 1994, during plague outbreak in district beed (maharashtra) and surat (gujarat) to monitor rodent/flea population and to determine susceptibility status of fleas to insecticides. the five rodent species in order of their prevalence were rattus rattus (86.06%), mus musculus (15.33%), suncus murinus (2.47%), bandicoota indica (0.48%) and b. bengalensis (0.48%). two flea species, xenopsylla cheopis and x. astia, were captured ... | 1996 | 8806038 |
| [parasitic infections among wild rats from two areas of kaohsiung]. | wild rats including four strains were captured for examination of parasitic infections. the numbers were 101 from areas of kaohsiung harbor and 98 from areas of kaohsiung airport. most of the examined wild rats were rattus norvegicus and second most were suncus murinus. the infection rates of intestinal helminths in rats of both areas did not display any significant difference. the overall infection rate was 29.6%. the infection rate was highest in r. norvegicus and the most frequently found par ... | 1996 | 8709181 |
| gr205171: a novel antagonist with high affinity for the tachykinin nk1 receptor, and potent broad-spectrum anti-emetic activity. | it has been demonstrated recently that antagonists of the tachykinin nk1 receptor, specifically cp-99,994 and gr203040, possess anti-emetic activity in a range of species. to optimise this activity, a series of analogues based around the structure of gr203040 have been synthesised and their affinity at the human tachykinin nk1 receptor determined. in addition, the potency of these analogues to inhibit emesis induced in the ferret by whole-body x-irradiation has been examined. a range of substitu ... | 1996 | 8876035 |
| preference of lymphocyte-homing to high endothelial venules in palatine tonsils of musk shrew (suncus murinus). | we studied the lymphocyte-homing to palatine tonsils of the musk shrew, a new experimental animal originally developed in japan. the tonsils of the animals have typically high endothelial venules (hev) in the parafollicular region. the in vivo migration test showed that blood-circulating lymphocytes were able to home to the tonsils through the hev. the in vitro lymphocyte-hev binding assay clearly indicated the binding preference of the lymphocytes to be the tonsillar hev. first, binding of b ce ... | 1996 | 9082798 |
| the pharmacology of the emetic response to upper gastrointestinal tract stimulation in suncus murinus. | this paper is the first to describe aspects of the mechanics of retching in the insectivore suncus murinus (house musk shrew) and in an animal of such a small size (approximately 50 g). in anaesthetised animals using the novel stimulus of mechanical stimulation of the upper gastrointestinal tract as the provocative stimulus the frequency of retching was found to be about 4 retches/s, a much higher frequency than in other species (dog, cat, ferret). these studies show that quantification of retch ... | 1996 | 8836619 |
| seroepidemiology of hantaan virus infection in taiwan. | in order to investigate the infection rate of hantaan virus in taiwan, a total of 6,536 human serum samples were collected from residents, selected by stratified random sampling, from 19 townships covering four different ethnic groups: aborigines, fukien taiwanese, hakka taiwanese, and mainland chinese. serum samples were screened for hantaan virus antibodies by indirect immunofluorescence. the prototype hantaan virus (76/118)-infected vero e6 cells were used as the viral antigen for the antibod ... | 1996 | 8950687 |
| laboratory suncus: a new model animal for tonsil research. | palatine and tubal tonsils of normal and horseradish peroxidase (hrp) sensitized laboratory suncuses (suncus murinus) were examined by immunoelectron microscopy. the individual tonsil consisted of lymphoepithelial symbiosis containing m cells and a lymph nodule. the high-endothelial venules and efferent lymphatics were situated in the parafollicular region of the nodule. staining of the frozen tonsil sections by our recently developed anti-suncus t and b lymphocyte monoclonal antibodies revealed ... | 1996 | 9082781 |
| distribution of alpha- and beta-subunits of glycoprotein hormones in thyrogonadotroph in the anterior pituitary cells of the musk shrew (suncus murinus). | in order to examine the distribution pattern of alpha- and beta-subunits of glycoprotein hormones in small and large granules in the thyrogonadotrophs of the musk shrew, we used an antiserum against a synthesized peptide consisting of the sequence 37-53 of the rat alpha-subunit, which is highly conservative among several mammalian species, and also antisera to lh beta, fsh beta and tsh beta. both alpha- and lh beta-subunits were colocalized in what appeared at the light-microscopic level to be t ... | 1996 | 8993627 |
| hair growth and skin in the kinky-coat (kc) musk shrew, suncus murinus. | hair growth and skin structure were examined in kinky coat (kc) musk shrews, suncus murinus. the first hair growth cycle and the development of hair bulbs were normal. histological characteristics of hair follicles and bulbs were similar in kc/kc and normal +/kc shrews. the mean thickness of epidermis and dermis did not differ significantly between the kc/kc and +/kc shrews. and no histological abnormalities were observed in the epidermis, dermis and hypodermis of the kc/kc shrews. consequently, ... | 1996 | 8840138 |
| liver apoptosis after dimethylnitrosamine administration in shrews. | female house musk shrews (suncus murinus, insectivora) were given a single i.p. dose of 30 mg/kg dimethylnitrosamine (dmn) at 8 weeks of age which was lethal 36 to 48 hrs after dosing. liver tissues were collected from shrews killed 3, 6, 16, 24 and 36 hrs after treatment, and the sequential development of the lesions was characterized. dmn induced acute centrilobular cell injury. in 6 hrs, a few cells became apoptotic in the centrilobular area; the number increased at 16 hrs and 24 hrs, and was ... | 1996 | 8811299 |
| presence and structure of anal and vaginal tonsils in the laboratory shrew (suncus murinus). | in all the laboratory shrews (suncus murinus) examined, a pair of tonsil-like structures was found at the boundary between the anus and the ostium urogenitoanalis. moreover, the same tissues were recognized between the vagina and the ostium urogenitoanalis in 9 of the 13 females examined. they indicated clear epitheliolymphocyte symbiosis around both mucosal crypts (anal and vaginal crypts) and outer lymph nodules including the germinal centers, and were demarcated from other tissues by the fibr ... | 1996 | 8712373 |
| [mechanisms of cytotoxic drug-induced emesis and its prevention]. | in this review, i have attempted to provide an overview of the pathways by which cytotoxic drugs induce emesis. the mechanisms of serotonin 5-ht3 antagonists and new antiemetics are also discussed. old data especially from the experiments employing area postrema ablation must be re-evaluated because it is likely that the operation has damaged other important nucleus in the brain stem. therefore, the concept of the chemoreceptor trigger zone and "vomiting center" proposed by borison et al. in 195 ... | 1996 | 8855716 |
| marked depression of radiation-induced emesis by olfactory bulbectomy or pre-exposure using low doses. | acute emetic response to relatively low-doses of x-irradiation on suncus (suncus murinus) was examined. the behaviors recorded for each subject, using a video-cassette recorder system, were (1) the number of emesis, during exposure to a dose of 3.0 gy; (2) emesis threshold. results showed that the emetic threshold was observed at 0.85 gy, and the number of radioemesis during exposure was 29. however, the observed threshold dose became 2.22 gy following olfactory bulbectomy. the emetic number dec ... | 1996 | 8631391 |
| development of a laboratory colony of the musk shrew (suncus murinus, insectivora) exhibiting a high incidence of spontaneous diabetes mellitus. | 1996 | 8699804 | |
| developmental pattern of axonal pathways in the house shrew maxillary nerve. | the topographic patterns of peripheral receptors and effectors seem to contribute to the construction of the neuronal circuit in the central nervous system (cns) in mammals. many patterns replicating those of the periphery have been found in the cns, and fasciculation has been regarded as having a central role in the pattern replication. the house shrew, suncus murinus, is an excellent species in which to study this topic because it has a vibrissae system arranged in a single ordered fashion and ... | 1996 | 8849667 |
| prophylactic effect of serotonin uptake inhibitors against motion sickness in suncus murinus. | the prophylactic effect of serotonin uptake inhibitors, imipramine and fluoxetine, against motion sickness was investigated in suncus murinus. imipramine (s.c.) and fluoxetine (i.p.) inhibited motion-induced emesis dose dependently with id50 values of 1.7 and 26 mg/kg, respectively. the results suggest that increasing the concentration of serotonin in the synaptic cleft can prevent motion-induced emesis and that serotonin uptake inhibitors are effective as anti-motion sickness drugs. | 1996 | 8864690 |
| the period of ovulation and presence of the first polar body of ova ovulated in the house musk shrew (suncus murinus). | the period of ovulation in mature house musk shrews was examined in a natural mating group and a superovulation group treated with gonadotropin. in the natural mating group, ovulation started 14 hr after mating in 3 of the 7 house musk shrews (42.8%), and occurred in all 5 house musk shrews by 15 hr after mating. in the superovulation group, ovulation started 13 hr after the administration of hcg in 3 of the 5 house musk shrews, and was observed in all 5 shrews by 16 hr after the administration. ... | 1997 | 9353637 |
| behavioral regulation of gonadotropin-releasing hormone production. | in vertebrates reproductive readiness requires coordination between the sexes. behavioral interactions with potential mates can initiate the neuroendocrine events that are required for successful copulation, ovulation, and fertilization. regardless of the efferent pathway used, their targets are the neurons that produce and secrete gonadotropin-releasing hormone (gnrh). several excellent animal models are currently under use to study the relationship between behavior and gnrh. in the musk shrew ... | 1997 | 9370211 |
| ethanol-induced emesis in the house musk shrew, suncus murinus. | ethanol-induced emesis were investigated using suncus murinus and the emetogenic mechanisms of ethanol were compared with those of cisplatin. intraperitoneal injection of ethanol caused dose-dependent emesis with ed50 value of 22.3% (v/v) when injection volume was adjusted to 4 ml/kg. intraperitoneal and subcutaneous injection of acetaldehyde also caused dose-dependent emesis (ed50 = 3.5% (v/v) with an extremely shorter latency (6% i.p.: 1.0 +/- 0.3 min cf. 40% ethanol: 13.0 +/- 1.9 min). neithe ... | 1997 | 9010480 |
| selective inhibitors of cyclic amp-specific phosphodiesterase: heterocycle-condensed purines. | to reverse the adverse reactions of alkylxanthines and to develop novel inhibitors of cyclic amp-specific phosphodiesterase (pde iv), a series of heterocycle-condensed purines were designed and synthesized. some of these new compounds had similar or more potent and selective inhibitory activity against pde iv than known pde iv inhibitors. the tracheal-relaxant activity of these compounds was closely correlated with their pde iv-inhibitory activity. moreover, these purine analogues did not have a ... | 1997 | 9379444 |
| the unusual state of the cumulus oophorus and of sperm behaviour within it, in the musk shrew, suncus murinus. | in the musk shrew, suncus murinus, the behaviour of the cumulus-egg complex and its interaction with spermatozoa were unusual in several respects. the cumulus oophorus was ovulated about 15.5 h after mating or treatment with hcg as a hyaluronidase-insensitive matrix-free ball of cells which remained for relatively long periods of about 14 h around fertilized, and for about 24 h around unfertilized eggs. as a probable function of the small number of up to about 10 or 20 spermatozoa that generally ... | 1997 | 9227366 |
| ovulation induction and gamete transport in the female tract of the musk shrew, suncus murinus. | the musk shrew suncus murinus was studied with regard to induction of ovulation, the genesis and role of the vaginal copulation plug, and the behaviour of gametes and embryos within the fallopian tube. ovulation occurred about 15 h after ejaculation, which required a mean of 5.2 (range 2-10) intromittent thrusts. since ovulation occurred also after five thrusts without ejaculation, and after ejaculation without plug formation or sperm deposition, the primary stimulus for this seemed to be the th ... | 1997 | 9227365 |
| antiemetic effects of morphine on motion- and drug-induced emesis in suncus murinus. | emetic and antiemetic effects of morphine were investigated in suncus murinus. subcutaneous (up to 30 mg/kg) or intracerebroventricular administration (50 micrograms) of morphine failed to cause emesis. however, pretreatment with morphine (s.c.) prevented the emesis induced by nicotine (10 mg/kg, i.p.), copper sulfate (40 mg/kg, p.o.), cisplatin (20 mg/kg, i.p.) and motion stimulus. these results suggest that morphine has only antiemetic potency and may block a common mechanism for the emetic re ... | 1997 | 9255411 |
| blood supply to the retina in the laboratory shrew (suncus murinus). | the blood supply to both retinae was studied light microscopically and by scanning electron microscopy in 48 adult laboratory shrews (suncus murinus) of both sexes. thirty-eight of the animals were injected into the left ventricle with neoprene latex (du pont. 601a) or with mercox (dai nippon ink ltd., cl-2r) to elucidate the blood supply to the retina from the ophthalmic artery. the remaining animals were kept for histological study of the retina. the central retinal artery, originating from th ... | 1997 | 9229077 |
| involvement of a peripheral mechanism in the emesis induced by cardiac glycosides in suncus murinus. | the ability of three cardiac glycosides, ouabain, digitonin and digitoxin, to induce emesis and their mechanism(s) of action were investigated in suncus murinus. the intraperitoneal injection of ouabain but not digitonin nor digitoxin caused vomiting in a dose-dependent manner. however, the administration of ouabain into the cerebroventricle did not cause emesis. ouabain-induced emesis was partly prevented by surgical abdominal vagotomy. pretreatment with tropisetron, a selective 5-ht3 (5-hydrox ... | 1997 | 9178926 |
| coexistence of tyrosine hydroxylase and serotonin in the raphe nucleus of the laboratory shrew (suncus murinus) during postnatal life. | immunoreactivity (ir) of tyrosine hydoroxylase (th), which is the rate-limiting enzyme of catecholamine (ca) synthesis, was observed in the serotonergic neurons of the raphe nucleus (rn) of the newborn laboratory shrew from postnatal day (p) 0 to p14. using an immunohistochemical method involving highly specific antibodies produced in our laboratory, we found that these rn neurons were th-, gtp cyclohydrolase i-, aromatic l-amino acid decarboxylase-immunoreactive, but dopa- and dopamine-immunone ... | 1997 | 9088574 |
| comparative anatomical studies on the thyroid and thymic arteries. v. house musk shrew (suncus murinus). | the thyroid and thymic arteries were investigated in 36 male and 36 female house musk shrews. the superior thyroid artery was constant. the artery arose, in the most instances, from the external carotid arteries. the artery, in about one fourth instances, sent both the superior and inferior branches supplying the gland and the former branch terminated in the superior and inferior laryngeal arteries. the latter branch was independent in the remaining instances. the superior laryngeal artery was i ... | 1997 | 9128061 |
| robertsonian chromosomal variation in the house musk shrew (suncus murinus, insectivora:soricidae) and the colonization history of the species. | a high-resolution g-banding technique was used to identify five metacentrics that characterize suncus murinus from sri lanka. these metacentrics were shown to be the product of robertsonian fusion of acrocentric chromosomes identical to those in the standard karyotype defined by m.b. rogatcheva et al. two of the metacentrics in the sri lankan shrews (rb(10.12) and rb(14.15)) were the same as those reported by c.h. sam et al. in malayan populations of s. murinus. this finding provides strong supp ... | 1997 | 9061910 |
| [chromosome coupling in robertsonian heterozygotes in common (sorex araneus) and musk (suncus murinus) shrews]. | 1997 | 9376804 | |
| [geography of chromosomes of natural populations of the shrews sorex araneus and suncus murinus]. | the geographic distribution of chromosome races of two shrew species (sorex araneus and suncus murinus) was analyzed on the basis of published data and personal results. it was shown that expansion of both species was accompanied by fixation of different chromosome rearrangements (mainly robertsonian translocations) in isolates. chromosome polymorphism studied from the viewpoint of ecology and geography of these species allows reconstruction of their evolutionary history and understanding of the ... | 1997 | 9378305 |
| low activity of aldehyde dehydrogenase (aldh) in liver of suncus murinus: possible explanation for high sensitivity to alcohol. | suncus murinus (suncus) is an animal species highly sensitive to ethanol (lin, s.-c., saito, h., yohro, t. and shiga, j.,j. toxicol. env. health, 18: 575-587, 1986). to elucidate the mechanism involved in sensitivity to alcohol, we investigated that properties of alcohol dehydrogenase (adh) and aldehyde dehydrogenase (aldh) in the suncus in comparison with the rat. the activities of aldh in microsomes and mitochondria of suncus livers were lower than those in rat livers, although the activity of ... | 1997 | 9198008 |
| superovulation induction in the house musk shrew (suncus murinus). | the number of ovulated oocytes in the adult house musk shrews was examined by natural mating. the positive rate of ovulation was 83.3%, and the mean number of ovulated oocytes was 4.4 +/- 1.9 (mean +/- sd). the induction of superovulation was examined by administering either pregnant mare's serum gonadotropin (pmsg) or human chorionic gonadotropin (hcg), exogenous gonadotropin, to house musk shrews. as a result, the number of ovulated oocytes were within the number of oocytes ovulated spontaneou ... | 1997 | 9250478 |
| male/female differences in drug-induced emesis and motion sickness in suncus murinus. | in order to elucidate possible male/female differences in emesis, the effects of various emetogenic drugs (cisplatin, copper sulfate, veratrine, nicotine, serotonin) and motion stimulus were compared between male and female suncus murinus. cisplatin (ip), nicotine (sc), veratrine (sc) and copper sulfate (po) induced dose-dependent emesis in either sex, and there was no apparent difference in estimated ed50 values. however, male animals tended to be more susceptible to serotonin-induced emesis. t ... | 1997 | 9258999 |
| pepsinogens and pepsins from house musk shrew, suncus murinus: purification, characterization, determination of the amino-acid sequences of the activation segments, and analysis of proteolytic specificities. | three pepsinogens, namely, pepsinogens a, c-1, and c-2, were purified from gastric mucosa of adult house musk shrew (suncus murinus) by conventional chromatographic and gel filtration procedures. the molecular masses were 40, 39, and 41 kda for pepsinogens a, c-1, and c-2, respectively. pepsinogen c-2 contains an asn-linked carbohydrate chain(s) of about 2 kda. each pepsinogen was converted to pepsin through an intermediate form under acidic conditions. by nh2-terminal sequence analysis of these ... | 1997 | 9354369 |
| localization of the genes for major ribosomal rna on chromosomes of the house musk shrew, suncus murinus, at meiotic and mitotic cells by fluorescence in situ hybridization and silver staining. | the genes for major ribosomal rna were localized on chromosomes 5pter-p15, 9q64-qter, and 13q38-qter of the house musk shrew, suncus murinus (insectivora, soricidae) by silver staining of mitotic metaphase and meiotic pachytene spreads and fluorescence in situ hybridization using the human 28s-rna genes as a probe to mitotic metaphase spreads. the data presented indicate a correlation between sites of in situ hybridization and silver staining. the finding of nuclear materials in mitosis was in a ... | 1997 | 9418261 |
| significance of the localization of large granules in the thyrogonadotrophs of the musk shrew (suncus murinus). | in order to examine the significance of small round and large granules in the thyrogonadotrophs of the musk shrew, we investigated the differences of numbers, distribution patterns and/or immunoreactivities of the large granules in the thyrogonadotrophs among the newborn, infant and adult musk shrews. as a result, we observed that the thyrogonadotrophs exist in newborn musk shrew, but the large granules were few in number and immunoreactivity on the granules was weak. the ratio of the number of ... | 1997 | 9225488 |
| opposite effects of isoniazid and fasting on the expression of cyp2e1 protein and mrna in house musk shrew (suncus murinus). | the effects of isoniazid and fasting on hepatic cyp2e1 in the suncus were investigated. aniline hydroxylation and n-nitrosodimethylamine demethylation, which are known to be catalyzed by cyp2e1, in liver microsomes were induced and suppressed by the treatment with isoniazid and the fasting, respectively. immunoblot analysis indicated that cyp2e1 protein in liver microsomes from isoniazid-treated suncus was increased in contrast to the result with the fasting of the suncus. northern blot analysis ... | 1997 | 9063569 |
| segregation analysis of animal pedigree data from inter-population crosses. | the general method of segregation analysis of pedigree data has been developed and widely used in human genetics. we modified this method to examine pedigree data coming from inter-population crosses. these kinds of pedigrees are common in laboratory and farm animal breeding. this paper describes a rationale for the method and illustrates its application to the study of inheritance of litter size and of male sterility in hybrid stock of the house musk shrew (suncus murinus) derived from crosses ... | 1997 | 9511225 |
| distribution pattern of hnf-3beta proteins in developing embryos of two mammalian species, the house shrew and the mouse. | the pattern of expression of hnf-3beta in organizing centers and axial structures during early vertebrate development suggests an important role for this protein in the establishment of the vertebrate body plan. to establish whether the pattern of expression during embryogenesis is species specific, a comparative immunohistochemical study of two mammalian species, the house shrew, insectivore, and the mouse was carried out; it is difficult to obtain accurate morphological differences from the st ... | 1997 | 9493826 |
| entomological and rodent surveillance in plague-suspected areas during september 1994 and thereafter. | studies carried out in the states of maharashtra, gujarat, uttar pradesh and union territory of delhi after the bubonic plague outbreak during 1994 revealed the presence of seven species of rodents, viz. rattus rattus, r. norvegicus, mus. musculus, tatera indica, suncus murinus, bandicoota bengalensis and b. indica. the flea species encountered were xenopsylla cheopis and x. astia. the x. cheopis and x. astia index recorded in different areas of beed district of maharashtra; surat, vadodra and b ... | 1997 | 9556751 |
| inhibition of anaesthetic-induced emesis by a nk1 or 5-ht3 receptor antagonist in the house musk shrew, suncus murinus. | the effects of a nk1 antagonist, gr205171, and a 5-ht3 antagonist, ondansetron, in a novel model of post-anaesthesia-induced emesis in suncus murinus is described. gr205171 (1 and 3 mg k(-1) s.c) and ondansetron (3 mg kg(-1) s.c.) each significantly inhibited emesis. this model may be useful for studying drugs to treat post-operative nausea and vomiting in man. | 1998 | 9886687 |
| a new spontaneous animal model of niddm without obesity in the musk shrew. | the eds (early-onset diabetes in suncus) colony has been developed as a new closed breeding colony of the musk shrew (suncus murinus, insectivora) exhibiting a high incidence of spontaneous diabetes mellitus. we investigated the characteristic features of diabetic shrews in this colony. all diabetic shrews are characterized by glycosuria (tes-tape value > or = 3+), hyperglycemia (23.3 +/- 0.8 mmol/l) and polyuria, and they were affected by the age of 3 months. cumulative incidence (64.1% in male ... | 1998 | 9515557 |
| molecular cloning of sucrase-isomaltase cdna in the house musk shrew suncus murinus and identification of a mutation responsible for isolated sucrase deficiency. | isolated sucrase deficiency has been demonstrated in a line of house musk shrew, suncus murinus (laboratory name: suncus). this animal belongs to the order insectivore and is phylogenetically different from ordinarily used laboratory animals. they are believed to have evolved with mainly animal food without sucrose. to study the molecular basis of the sucrase deficiency in suncus, we cloned 6. 0-kilobase (kb) sucrase-isomaltase (si, ec 3.2.1.48-10) cdna from suncus intestinal cdna library. the c ... | 1998 | 9632713 |
| neuromuscular transmission and innervation in the urinary bladder of the insectivore suncus murinus. | in isolated preparations of the urinary bladder detrusor of the house musk shrew suncus murinus (order: insectivora; family: soricidae), electrical field stimulation (0.5-32 pulses/s) evoked neurogenic contractile responses that were markedly attenuated by atropine (1 microm). the non-cholinergic component was reduced but not abolished by the p2-purinoceptor antagonist, suramin (300 microm). thus, neuromuscular transmission in the suncus urinary bladder is effected by cholinergic and purinergic ... | 1998 | 9672121 |
| [update on plague in madagascar]. | after a thirty year period of successful control, bubonic plague showed the first signs of return in madagascar where a fatal outbreak occurred in antananarivo in 1978. a second outbreak was observed in mahajanga in 1991 after more than a half century. in 1997, 459 confirmed or presumptive cases were reported, as compared to 150 to 250 cases during the last years. however the actual extent of this recrudescence must be placed in the perspective of a more efficient control program that has led to ... | 1998 | 9812306 |
| sex differences in mammalian and chicken-ii gonadotropin-releasing hormone immunoreactivity in musk shrew brain. | many vertebrates have more than one molecular form of gonadotropin-releasing hormone (gnrh) present in brain. in all cases documented to date, gnrh neurons located in the forebrain are critical players in the brain-pituitary-gonadal feedback axis although the details of how steroids regulate gnrh remain elusive. the function of the second form, usually produced in cells in the midbrain, is not known. it has been hypothesized that this gnrh acts as a neurotransmitter. in the musk shrew (suncus mu ... | 1998 | 9843640 |
| neonatal androgen affects copulatory behavior in the female musk shrew. | the role of neonatal testosterone in the development of copulatory behavior was examined in an insectivore, the musk shrew (suncus murinus). female musk shrews were treated with testosterone propionate (tp) for the first 5 days of life and then tested in adulthood for either female or male-like copulatory behavior. early tp had a masculinizing effect; neonatally treated animals mounted a stimulus female more frequently, and with shorter latencies, in response to adult testosterone treatment than ... | 1998 | 9878272 |
| isolation and characterization of helicobacter species from the stomach of the house musk shrew (suncus murinus) with chronic gastritis. | a gram-negative, motile bacterium with bipolar sheathed flagella (one at each end) was isolated from the stomach of house musk shrews (suncus murinus) with chronic gastritis. the isolates grew at 37 degrees c under microaerophilic conditions, but not under aerobic conditions; rapidly hydrolyzed urea; were catalase, oxidase, alkaline phosphatase, and arginine aminopeptidase positive; reduced nitrate to nitrite; and were resistant to cephalothin and nalidixic acid, but sensitive to tetracycline, e ... | 1998 | 9625789 |
| brainstem origin of the efferent components of the cervical vagus nerve in the house musk shrew, suncus murinus. | the brainstem origin of the efferent neurons of the vagus nerve in the house musk shrew, an animal species which has been recently used in researches on emesis, was studied using the retrograde tracing method. the vagus nerve was exposed and cut at the mid-cervical level below the nodose ganglion. horseradish peroxidase was applied to the proximal end of the cut nerve. the brainstem was sectioned and processed histochemically with the tetramethylbenzidine method. the horseradish peroxidase injec ... | 1998 | 9722195 |
| ascending projections from the area postrema and the nucleus of the solitary tract of suncus murinus: anterograde tracing study using phaseolus vulgaris leucoagglutinin. | suncus murinus (suncus) is a new experimental animal model for research on the mechanisms underlying emesis. in the present study, we examined the ascending projections from the area postrema (ap) and the nucleus of the solitary tract (nts) in suncus based on anterograde transport of phaseolus vulgaris leucoagglutinin. the ap projected heavily to the dorsal vagal complex, especially in the commissural and medial subnuclei of the nts, and the dorsal motor nucleus of the vagus. some ascending fibe ... | 1998 | 9715082 |
| phylogenetic positions of insectivora in eutheria inferred from mitochondrial cytochrome c oxidase subunit ii gene. | for the elucidation of the phylogenetic position of insectivora in eutheria, we have sequenced the cytochrome c oxidase subunit ii (coii) gene of mitochondria for three insectivoran species [musk screw (suncus murinus), shrew mole (urotrichus talpoides), japanese mole (mogera wogura)] and analyzed these amino acid sequences with neighbor-joining (nj) method and maximum likelihood (ml) method. nj analysis shows polyphyly of insectivora and chiroptera. assuming that each of primates, ferungulata, ... | 1998 | 9615624 |
| inheritance of male hybrid sterility in the house musk shrew (suncus murinus, insectivora, soricidae). | two geographic races of the house musk shrew (suncus murinus) were crossed and intercrossed in the laboratory. many cases of male sterility were detected among the hybrids. segregation analysis of the pedigree data showed that the inheritance of male sterility in interracial hybrids of s. murinus can be described within the framework of monogene polyallele model with sterility of a single allele combination. this model is similar if not identical to that proposed by dobzhansky and muller. | 1998 | 9924792 |
| parvalbumin immunoreactive neurons in the main olfactory bulb of the house musk shrew, suncus murinus. | the distribution, morphological features, and postnatal development of parvalbumin (pv) immunoreactive neurons in the main olfactory bulb (mob) of the house musk shrew, suncus murinus, were studied to report for the first time on pv positive bulbar interneurons in the order insectivora. in adult animals, pv neurons are distributed in the glomerular layer (gl), the external plexiform layer (epl), the internal plexiform layer (ipl) and the granule cell layer (gcl) of the mob. these neurons were id ... | 1998 | 9807013 |
| induction of fos-like immunoreactivity in musk shrews after mating. | in many mammalian species the neuroendocrine regulation of male and female reproductive behavior is sexually dimorphic. by contrast, many features of female sexual behavior in the musk shrew (suncus murinus) more closely resemble those of males than of females of other species. female musk shrews require testosterone (t), which is neurally aromatized to estrogen, to induce sexual behavior. aromatization occurs in the medial preoptic area (mpoa), and this region is critical for the expression of ... | 1998 | 9804874 |
| inheritance of litter size at birth in the house musk shrew (suncus murinus, insectivora, soricidae). | in this research we estimated the contribution of a major-gene effect to the control of litter size in hybrids between two local populations of the house musk shrew (suncus murinus). segregation analysis was performed on the basis of a mixed polygene and major-gene model. the model presumes that two parental populations may differ from each other in gene frequencies and in the values of polygenic effects but not in the major-gene contribution of the trait. moreover, the peculiarity of the trait- ... | 1998 | 9674383 |
| brainstem topology of the vagal motoneurons projecting to the esophagus and stomach in the house musk shrew, suncus murinus. | the central origin of vagal efferents innervating the esophagus and stomach in the house musk shrew, suncus murinus, was studied using the retrograde tracing technique. the animals were perfused with fixative 48-72 h after hrp injection and sections were processed by hrp histochemistry. hrp application into the gastroesophagus resulted in bilateral labelling of neurons in the dorsal motor nucleus of the vagus nerve (dmx) and ambiguous nucleus (an). labelled neurons in the dmx were observed from ... | 1998 | 9626945 |
| branches of the vagus nerve destined for the heart and the adjoining great vessels in the house shrew, suncus murinus, with reference to the terminology of the vagal cardiac branches. | in order to help to organize the understanding of the bewildering complexities of the innervation of the mammalian heart by the vagus nerve and to clear up of confusions as regards the vagus cardiac branches, we scrutinized these branches in the adult house shrew, suncus murinus, under a stereomicroscope. a number of branches were given off from the vagus nerve not only to the heart, but also to the adjoining great vessels, both outflowing and inflowing. when compared from the developmental view ... | 1998 | 9617080 |
| open eyelids at birth, a new mutation in the musk shrew, suncus murinus. | the mutation designated "open eyelids at birth" arose spontaneously in the ban strain of the musk shrew (suncus murinus). this is the first report on this kind of mutation in the shrew. mating experiments suggested that the mutant character is controlled by an autosomal recessive gene with about 43% penetrance. the symbol oeb(open eyelids at birth) was proposed for the mutant gene. affected shrews were fully viable and fertile. phenotypically, the affected shrews were characterized by one or bot ... | 1998 | 9606420 |
| chromosome pairing in inter-racial hybrids of the house musk shrew (suncus murinus, insectivora, soricidae). | two chromosome races of the house shrew suncus murinus that differ from each other for five robertsonian translocations (8.17, 9.13, 10.12, 11.16, and 14.15), heterochromatic insertions in chromosomes 7 and x, and multiple rearrangements in the y chromosome were crossed and then intercrossed in captivity to produce a hybrid stock. electron-microscopic analysis of synaptonemal complexes in fertile and sterile hybrid males was carried out. meiosis in sterile males did not progress beyond pachytene ... | 1998 | 9549061 |
| serotonergic neurons are present and innervate blood vessels in the olfactory bulb of the laboratory shrew, suncus murinus. | the distribution and characteristics of serotonin-immunoreactivity in the olfactory bulb of the laboratory shrew (suncus murinus, insectivore) was studied immunohistochemically. serotonergic neurons were found only in the subependymal layer of the main olfactory bulb. these neurons were 8-12 microm in size and bipolar in shape. these serotonergic neurons had smooth nerve fibers which innervate blood vessels located mainly in the subependymal layer of the main olfactory bulb. on the other hand, o ... | 1998 | 9535111 |
| oxidation of fatty acids by kidney microsomes of musk shrew (suncus murinus). | substrate specificity and other properties of a fatty acid monooxygenase system in kidney microsomes of the japanese house musk shrew (suncus murinus) were examined. the suncus kidney microsomes catalyzed the hydroxylation of various saturated and unsaturated fatty acids to the omega- and (omega-1)-hydroxy derivatives. laurate was most effectively hydroxylated among saturated and unsaturated fatty acids. the specific activity (53.79 +/- 5.59 [mean +/- sd, n = 6] nmol/nmol cytochrome p450/min) of ... | 1998 | 9530812 |
| chromosomal segregation and fertility in robertsonian chromosomal heterozygotes of the house musk shrew (suncus murinus, insectivora, soricidae). | crucial to our understanding of chromosomal variation and evolution in mammals are detailed studies of chromosomal heterozygotes, with analyses of chromosomal segregation and chromosome-derived infertility. we studied segregation and fertility in hybrids between karyotypic races of the house musk shrew suncus murinus. these individuals were heterozygous for up to five robertsonian fusions (rbs) and an insertion of heterochromatin in an autosome. all variant chromosomes showed mendelian segregati ... | 1998 | 9800372 |
| appearance and distribution of two ca2+-binding proteins during development of the cochlea in the musk shrew. | in the developing cochlea of the musk shrew, suncus murinus, the localization of two ca2+-binding protein, calbindin and calmodulin, which are thought to play different roles in the nervous system, was examined during gestational and postpartum periods. calbindin is thought to play a ca2+ buffering role, while calmodulin activates other proteins. cochleae from the musk shrews sacrificed from gestational day (gd) 15 to postnatal day (pp) 9 and as adults, were immunohistochemically analyzed. the l ... | 1998 | 9733905 |
| toxin-induced iddm (insulin dependent diabetes mellitus) in the musk shrew. | we administered streptozotocin (stz) and alloxan (al) to the musk shrew (suncus murinus, insectivora) to determine the effective diabetogenic dose of the two toxins for this species. a single intraperitoneal (i.p.) injection of 75 mg/kgbw or the consecutive 5-day s injection of 25 mg/kgbw of stz to non-fasted shrews, effectively (100%) induced hyperglycemia (> or = 300 mg/dl) with hypoinsulinaemia (< 30% of control level) in male shrews at 10 days after administration. morphological studies show ... | 1998 | 9718069 |
| an xxy sex chromosome constitution in a house musk shrew (suncus murinus l.) with testicular hypoplasia. | an adult male house muck shrew with an xxy sex chromosome constitution was found in a laboratory-bred colony. maternal origin of the additional x chromosome was demonstrated. the external appearance of the animal was normal, but the testes were small and displayed a high density of interstitial cells. the seminiferous tubules were narrow and contained only sertoli cells. | 1998 | 9713381 |
| co-localization of estrogen receptor and aromatase enzyme immunoreactivities in adult musk shrew brain. | estrogens are produced by the aromatization of androgens. these steroids exert their actions after binding to their receptors. past studies have shown that estrogen receptors (er) and aromatase enzyme (arom) reside in many of the same brain regions. few studies, however, have examined the neural co-localization of these important components involved in estrogen-activated behaviors. in the present study we examined the co-localization of er and arom immunoreactive (ir) neurons in musk shrew (sunc ... | 1998 | 9698499 |
| characterisation of 5-ht2 receptor subtypes in the suncus murinus intestine. | the involvement of 5-ht2 receptor subtypes in mediating a contraction response in the isolated intestine of suncus murinus was investigated using doi ((+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-amino-propane, a 5-ht2 receptor agonist) which produced a bell-shaped concentration response curve that was significantly (p < 0.05) reduced by methysergide (a 5-ht1/2 receptor antagonist, 1 microm) but not ketanserin (a 5-ht2a receptor antagonist, 1 microm), yohimbine (a 5-ht2b receptor antagonist, 1 microm) ... | 1999 | 10554884 |
| variables of movement amplitude and frequency in the development of motion sickness in suncus murinus. | the aim of the present study was to investigate the effect of different frequency and amplitude of horizontal movements to induce motion sickness and to identify gender differences and adaptation to motion stimulus in adult suncus murinus. each animal was subjected to a horizontal motion stimulus of 3, 7, 13, or 40 mm amplitude at a frequency of 0.5, 1, 2, or 3 hz. the number of vomiting episodes and the latency of onset were recorded over a 10-min period. for the study of adaptation, different ... | 1999 | 10495005 |
| characterization of the 5-hydroxytryptamine receptors mediating contraction in the intestine of suncus murinus. | 1. the effects of 5-ht and 5-ht agonists to induce contraction and the 5-ht receptors mediating these effects were investigated in the proximal, central and terminal intestinal segments of suncus murinus. 2. the contraction curves to 5-ht (3 nm - 30 microm) were shifted to the right by methysergide (1 microm) and ritanserin (0.1 microm), without affecting the maximum response. 3. in the central and terminal segments (but not the proximal segments) ondansetron (1 microm) and atropine (1 microm) s ... | 1999 | 10482918 |
| a parasympathetic ganglion innervating the harderian gland and lacrimal gland of the musk shrew (suncus murinus): fluorescent tracing and immunohistochemical studies. | a small ganglion, named the peri-trigeminal ganglion (ptg), was found in the ventromedial border of the rostral half of the trigeminal ganglion (tg) in the musk shrew (suncus murinus). in frontal sections, the ptg was semicircular or elliptical in shape. most of the neurons constituting this ganglion were round in shape and much smaller than those of the tg. the retrograde fluorescent tracer fluoro-gold was injected into various regions of the face in order to investigate innervation by the ptg ... | 1999 | 10480019 |
| sequence variation and evolution of the mitochondrial dna control region in the musk shrew, suncus murinus. | the complete mitochondrial dna (mtdna) control region was cloned and sequenced in the musk shrew, suncus murinus, insectivora. the general aspect was similar to that found in other mammals. we have found in two locations of this region the presence of arrays of tandem repeats like those in other shrew species. one array was located in the left domain containing the termination-associated sequences (tas) and the length of a copy was 77 bp. the other repeats were situated upstream from the recogni ... | 1999 | 10734607 |
| modulation of emesis by fentanyl and opioid receptor antagonists in suncus murinus (house musk shrew). | the anti-emetic mechanism of action of fentanyl to inhibit nicotine (5 mg/kg, s.c.)-induced emesis was investigated in suncus murinus. the anti-emetic action of fentanyl (40 microg/kg, s.c.) was antagonised by the opioid receptor antagonists naltrexone (1 mg/kg, s.c.), naloxone (1 mg/kg, s.c.), m8008 (16s-methylcyprenorphine; 1 mg/kg, s.c.) and mr 2266 (5,9-diethyl-2-(3-furylmethyl)2'-hydroxy-7,7-benzomorphan; 1 mg/kg) but not by naloxone methylbromide (1 mg/kg, s.c.), naloxone methyliodide (1 m ... | 1999 | 10422643 |
| distinctive neuronal organization of the olfactory bulb of the laboratory shrew. | the organization of the main olfactory bulb of an insectivore, the laboratory shrew (suncus murinus), was studied morphologically. we found particular small spherical regions, nidi, at the border between the glomerular and external plexiform layer (epl), which were intensely gad positive, 30-60 microm in diameter, and where no olfactory nerves were seen. around the nidus small calbindin d28k-positive gabaergic neurons, perinidal cells, were clustered. furthermore, a distinctive type of newly dis ... | 1999 | 10203320 |
| calbindin and calmodulin localization in the developing vestibular organ of the musk shrew (suncus murinus). | the distribution of the ca(2+)-binding proteins, calbindin and calmodulin, in the adult inner ear has been described previously. we undertook immunohistochemical investigation of developmental changes in the distribution of calbindin and calmodulin in the vestibular organ of the musk shrew (suncus murinus). expression of calbindin was seen first in the hair cells and the vestibular ganglion on gestational day (gd) 19, in nerve fibres on gd23 and in the otoconia on gd26. on gd19 calmodulin was de ... | 1999 | 10445073 |
| morphological features of the spermatic cord in the musk shrew (suncus murinus) with special reference to extratesticular leydig cells. | morphological features of the testicular artery and vein in the spermatic cord of the musk shrew (suncus murinus) were evaluated by light microscopy, transmission electron microscopy, corrosion cast technique combined with scanning electron microscopy and immunohistochemistry. the vascular architecture in the spermatic cord of the musk shrew was simple. the testicular artery in the musk shrew was straight and accompanied by 1 to 3 branches of testicular vein. the testicular vein was also straigh ... | 1999 | 10593578 |
| an odontometrical difference in the mandibular molars of two laboratory strains of the musk shrew, suncus murinus, derived from bangladesh and tokunoshima island of japan. | we investigated an odontometrical difference in the mandibular molars (m1, m2, and m3) of two laboratory strains of the musk shrew (suncus murinus) originating in bangladesh (ban strain) and tokunoshima island of japan (tku strain). we used skulls from two strains of shrews that were maintained under identical laboratory conditions. mesiodistal and buccolingual crown diameters in the trigonid and talonid of the mandibular molars were measured with a measuring microscope, calibrated to 0.001 mm. ... | 1999 | 10693326 |
| temporal aspects of female musk shrew (suncus murinus) sexual behavior. | the effects of testing condition on sexual behavior were examined in female musk shrews (suncus murinus). females were tested in 2 conditions, a pair test and a paced test. the pair test was similar to traditional sex test conditions in which the female and male are placed into the same chamber together until mating occurs. the paced condition allowed the female to leave the male's chamber and revisit him at will, thus "pacing" the interaction. females displayed receptivity continuously for 14 d ... | 1999 | 10098271 |
| inhibition of emesis by tachykinin nk1 receptor antagonists in suncus murinus (house musk shrew). | the anti-emetic potential of cp-122,721 ((+)-2s,3s)-3-(2-methoxy-5-trifluoromethoxybenzyl)amino-2-phenylpi peridine), cp-99,994 ((+)-(2s,3s)-3-(2-methoxybenzylamino)-2-phenylpiperidine), cp-100,263 ((-)-(2r,3r)-3-(2-methoxybenzylamino)-2-phenylpiperidine), rp 67580 ((3r, 7ar)-7,7-diphenyl-2-[1-imino-2-(2-methoxyphenyl)ethyl] po-hydroisoindol-4-one), fk 888 (n2-[(4r)-4-hydroxy-1-(1-methyl-1h-in-dole-3-yl)carbonyl-l-propyl] -n-methyl-n-phenylmethyl-1-3-(2-naphthyl)-alaninamide) and gr 82334 ([d-pr ... | 1999 | 10082206 |
| cortisol facilitates induction of sexual behavior in the female musk shrew (suncus murinus). | the role of cortisol in sexual behavior in the female musk shrew (suncus murinus) was examined. high levels of cortisol were associated with sexual receptivity, as indicated by species-typical tail-wagging behavior, during brief (15-min) mating tests. when cortisol production was blocked by metyrapone, an 11-beta-hydroxylase inhibitor, females exhibited reduced sexual behavior relative to controls, an effect that was reversed with acute cortisol replacement. these results indicate that cortisol ... | 1999 | 10197916 |
| delayed development of reflexes and hyperactive locomotion in the spontaneous mutant "waltzing" of the musk shrew, suncus murinus. | the autosomal recessive mutation waltzing (wz), displaying abnormal circling and head-shaking behavior, has previously been reported in the musk shrew (suncus murinus). postnatal development of reflexes and locomotor patterns in an open arena were examined in wz/wz mutant shrews. the wz/wz shrews showed extreme developmental delays in surface-righting reflex and negative geotaxis until 10-16 days after birth, but both reflexes eventually recovered to the levels of +/wz normal. nevertheless, the ... | 1999 | 10480024 |
| periodontitis in the house musk shrew (suncus murinus): a potential animal model for human periodontal disease. | our understanding of periodontal diseases has been facilitated greatly by the use of animal models. however, no animal model has been identified that truly reflects the disease seen in humans. suncus murinus, a rat-sized laboratory house musk shrew, has received attention as a valuable animal model due to ease of handling. in the studies described here, periodontal conditions in suncus murinus were evaluated to determine the usefulness of the shrew as an experimental model for understanding vari ... | 1999 | 10102558 |
| emesis in the shrew mouse (suncus murinus) induced by peroral and intraperitoneal administration of staphylococcal enterotoxin a. | peroral and intraperitoneal administration of staphylococcal enterotoxin a (sea) to suncus murinus elicited an emetic response. the 50% emetic dose of sea by peroral administration was found to be 32 microg per kg of body weight, whereas that by intraperitoneal administration was 3 microg per kg. multiple emetic responses occurred 70 to 108 min after peroral administration of an emetic dose of sea. similar responses occurred 65 to 102 min after intraperitoneal injection of an emetic dose of sea. ... | 1999 | 10571329 |
| sensitive assay of trimethylamine n-oxide in liver microsomes by headspace gas chromatography with flame thermionic detection. | to compare the trimethylamine n-oxygenase activity of liver microsomes from house musk shrew (suncus murinus) and rat, a sensitive method for the quantitation of trimethylamine (tma) n-oxide was developed using gas chromatography with flame thermionic detection. the limit of quantification was 0.5 microm and the calibration curve was linear at least up to 5 microm in incubations containing liver microsomal preparations from suncus. the intra-day rsd values ranged from 10.4 to 12.8 at 0.5 microm ... | 1999 | 10595729 |
| the effects of cyclophosphamide on neurotransmission in the urinary bladder of suncus murinus, the house musk shrew. | this study has shown that cyclophosphamide treatment of the insectivore suncus murinus, causes a down regulation in both muscarinic and p2x receptors, together with a reduced responsiveness to exogenous histamine (0.3 mm) in the urinary bladder. electrical field stimulation (70 v, 0.3 ms, 0.5-16 hz, 10 s every 5 min) of bladders from both control and cyclophosphamide-treated animals showed identical responses. since post-junctional alterations have been revealed by the reduced responsiveness to ... | 2000 | 10785278 |
| association of the developing acrosome with multiple small golgi units, the golgi satellites, in spermatids of the musk shrew, suncus murinus. | the spermatozoa of the musk shrew, suncus murinus, have a fan-like giant acrosome with a diameter of approximately 20 mm. the aim of this study was to investigate how this giant acrosome is constructed in the musk shrew spermatid and, in particular, how the golgi apparatus involved in acrosome formation behaves. the behaviour of the golgi apparatus was monitored by confocal laser scanning microscopy with antibody against a golgi-associated rab6 small gtpase. in the early golgi phase, small golgi ... | 2000 | 10864813 |
| effects of gonadotropin-releasing hormones, corticotropin-releasing hormone, and vasopressin on female sexual behavior. | the effects of intracerebroventricular (icv) infusion of four neuropeptides on female sexual behavior were examined in the female musk shrew (suncus murinus). in the first experiment, (icv) infusion of 100 ng of the mammalian form of gonadotropin-releasing hormone (mgnrh) facilitated rapid display of receptivity. gonadotropin-releasing hormone-infused females had shorter latencies to rump present and tail wag, compared with controls. in a second experiment, icv administration of the other form o ... | 2000 | 10868484 |
| pathogenicity of helicobacter species isolated from the stomach of the house musk shrew (suncus murinus). | 2000 | 10987673 |