Publications

clarification of emu serum for peptide hormone assay using polyethylene glycol precipitation.	interference in radioimmunoassays (rias) was frequently encountered during endocrinological studies of the emu (dromaius novaehollandiae). interference was greatest when serum was cloudy or opaque. such samples appeared seasonally, in spring and summer during the phase of fat deposition, and in the winter when females were laying. these poor quality samples did not allow accurate measurement by rias of several peptide hormones for a full year. to prepare them for assay, these sera were clarified ...	2003	12812780
synthesis of size-controlled cobalt ferrite particles with high coercivity and squareness ratio.	cobalt ferrite particles with diameters ranging from a few micrometer to about 15 nm were synthesized using a modified oxidation process. the fine control of the particle size was achieved by introducing various concentrations of fe(3+) ions at the beginning of the reaction. among the particle sizes obtained by using this method, particles with a grain size of about 36 nm showed a magnetization (m(s)) of 64 emu/g and a maximum coercivity (h(c)) of 2020 oe at room temperature. the corresponding s ...	2003	12804888
structures and magnetic behavior of 1-, 2-, and 3d coordination polymers in the cu(ii)-dicyanamide-pyrimidine family.	using aqueous conditions, three new coordination polymers containing cu(2+) cations, dicyanamide (dca) anions, and pyrimidine (pym) were isolated and structurally and magnetically characterized. comprising the bulk of the product yield, cu(dca)(2)(pym)(2), 1, crystallizes in the monoclinic space group p2(1)/c with a = 7.3569(5) a, b = 13.4482(9) a, c = 7.4559(5) a, beta = 98.984(3) degrees, and v = 728.6(1) a and forms linear 1d chains. the second compound, cu(dca)(no(3))(pym)(h(2)o), 2, is also ...	2003	12793834
synthesis and characterization of nickel nanoparticles by hydrazine reduction in ethylene glycol.	the synthesis of nickel nanoparticles by the hydrazine reduction of nickel chloride in ethylene glycol at 60 degrees c without soluble polymer as a protective agent was studied. it was found that an appropriate amount of naoh was necessary for the formation of pure nickel nanoparticles. also, it was not necessary to perform the reaction under a nitrogen atmosphere. by the analyses of x-ray diffraction, high-resolution transmission electron microscopy, and electron diffraction pattern, the result ...	2003	16256507
a neuroendocrine model for prolactin as the key mediator of seasonal breeding in birds under long- and short-day photoperiods.	seasonal breeding is associated with sequential increases in plasma luteinizing hormone (lh) and prolactin in the short-day breeding emu, and in long-day breeding birds that terminate breeding by the development of reproductive photorefractoriness. a model of the avian neuroendocrine photoperiodic reproductive response is proposed, incorporating a role for prolactin, to account for neuroendocrine mechanisms controlling both long- and short-day breeding. the breeding season terminates after circu ...	2003	12769227
aminomethyl-bipyridine bearing two flexible nitronyl-nitroxide arms: a new podand for complexation of transition metals in a facial or meridional conformation.	transition metal complexes of 6-aminomethyl-bis[methyl-2-(4,5-dihydro-4,4,5,5- tetramethylimidazolinyl-3-oxide-l-oxy)]-2,2'-bipyridine, bpyn(nit)(2), 1, have been synthesized and characterized by fab-ms, uv-vis, ft-ir, and epr spectroscopies, elemental analysis, and susceptibility measurements. single-crystal x-ray diffraction studies have been performed on all compounds giving the following crystal data: bpyn(nit)(2), 1, triclinic, p(-)1, z = 2, a = 10.7224(4) a, b = 11.0995(4) a, c = 13.1134(3 ...	2003	12716186
validation of the dca 2000 microalbumin:creatinine ratio urinanalyzer for its use in pregnancy and preeclampsia.	to determine the accuracy of the dca 2000 albumin/creatinine ratio urinanalyzer (bayer corp., elkhart, in) in uncomplicated pregnancy and preeclampsia.	2003	12648445
synthesis and structure of the metallic k6tl17: a layered tetrahedral star structure related to that of cr3si.	the title compound, the tl-richest in the k-tl system, has been synthesized in ta containers via direct reaction of the elements at 400 degrees c followed by quenching to room temperature and subsequent annealing at 150 degrees c for 4 weeks. it crystallizes in the orthorhombic space group cccm (no. 66) with a = 16.625(1) a, b = 23.594(2) a, c = 15.369(2) a (22 degrees c), and z = 8. two different tl(12) units consisting of augmented tetrahedral stars are condensed into layers of such tetrahedra ...	2003	12639115
verminous encephalitis apparently caused by the filarioid nematode chandlerella quiscali in emus (dromaius novaehollandiae).	verminous encephalitis attributed to chandlerella quiscali was diagnosed in a flock of emus (dromaius novaehollandiae). clinically affected birds showed torticollis and progressive ataxia. filarioid parasites with morphological characteristics resembling c. quiscali were identified in one case. histologic lesions in the brain and spinal cord consisted of mild to moderate perivascular cuffing and scattered areas of variable mild necrosis. parasites observed within the parenchyma of the brain and ...	2003	8363522
overexpression of bcl-2 in t cells affects insulitis in the nonobese diabetic mouse.	the nonobese diabetic (nod) mouse is a useful model for human autoimmune diabetes. the gene for the anti-apoptotic protein bcl-2 has previously been suggested as a probable susceptibility candidate for the nod mouse disease. in this study, we investigated how overexpression of bcl-2 in lymphocytes might affect insulitis in nod mice. a bcl-2 transgene expressed constitutively under the sv40-promoter and the 5'igh enhancer, emu, was bred onto nod background. two bcl-2 transgenic nod strains were p ...	2003	12662297
myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by e2f1 loss.	myc and e2f1 promote cell cycle progression, but overexpression of either can trigger p53-dependent apoptosis. mice expressing an emu-myc transgene in b lymphocytes develop lymphomas, the majority of which sustain mutations of either the arf or p53 tumor suppressors. emu-myc transgenic mice lacking one or both e2f1 alleles exhibited a slower onset of lymphoma development associated with increased expression of the cyclin-dependent kinase inhibitor p27(kip1) and a reduced s phase fraction in prec ...	2003	12718877
further comments on "long-term exposure of emu-pim1 transgenic mice to 898.4 mhz microwaves does not increase lymphoma incidence" by utteridge et al. (radiat. res. 158, 357-364 2002).		2003	12751966
roles of the stress-induced gene iex-1 in regulation of cell death and oncogenesis.	in response to changes in the external environment cells must initiate a coordinated program of gene expression for them to adapt. iex-1 (immediate early response gene x-1) is precisely regulated by multiple transcription factors among which p53, nf-kappab/rel, sp1 and c-myc play central roles, to ensure rapid and transient expression of iex-1 in cells under a variety of stress conditions. overexpression of iex-1 renders some cells sensitive to apoptosis and accelerates cell cycle progression, b ...	2003	12510147
aberrant expression of the lhx4 lim-homeobox gene caused by t(1;14)(q25;q32) in chronic myelogenous leukemia in biphenotypic blast crisis.	chromosomal aberrations observed in addition to the philadelphia chromosome in chronic myelogenous leukemia (cml) are likely to be involved in disease progression to the blast crisis. we describe here a t(1;14)(q25;q32) as an additional chromosomal aberration in a patient with cml in biphenotypic blast crisis. by use of long-distance inverse polymerase chain reaction (pcr), we cloned the chromosomal breakpoint and revealed that the immunoglobulin heavy chain gene is fused near its emu enhancer r ...	2003	14506703
the beta-globin hs4 insulator confers copy-number dependent expression of igh regulatory elements in stable b cell transfectants.	locus control regions (lcr) were first defined by their theoretical ability to enhance the expression of linked genes in a tissue-specific, position-independent and copy-number dependent manner. in fact, few of the so-called lcr identified completely fulfil this definition. for example, the regulatory elements located in 5' (emu) and 3' (hs3a; hs1,2; hs3b; hs4) of the igh locus display some properties of a lcr but lack a copy-number dependence and sometimes display position effects in transgenes ...	2003	14556968
combination of 3' and 5' igh regulatory elements mimics the b-specific endogenous expression pattern of igh genes from pro-b cells to mature b cells in a transgenic mouse model.	to ensure the b cell differentiation stage specificity of the intronic emu element and of the locus control region (lcr) that lies downstream of the igh chain locus, we generated transgenic mice harboring a v(h) promoter-gfp reporter gene linked to the 3'lcr region and the emu element. by flow cytometry, gfp(+) lymphocytes were observed amongst pro-b cells (b220(+)cd43(+)cd117(+)) and at all stages of differentiation up to mature b cells (b220(+)igm(+)igd(+)). expression was strictly confined to ...	2003	14572901
pathogenicity of a ratite-origin influenza a h5 virus in ostriches (struthio camelus).	ostriches were inoculated with a highly pathogenic avian influenza (hpai) virus of ratite origin, a/emu/texas/39924/93 (h5n2) done clb. the aim of this study was to evaluate the pathogenicity of this isolate for ostriches and to assess the ability of routine virologic and serologic tests to detect infection. avian influenza virus (aiv) was isolated from tracheal swabs from 2 to 12 days postinfection and from cloacal swabs from 3 to 10 days postinfection. aiv was also isolated from a wide range o ...	2003	14575143
distribution of spermatozoa in the outer perivitelline layer from above the germinal disc of emu and ostrich eggs.	in the present study, we determined the distribution of spermatozoa in the perivitelline layer above the germinal disc (gd) of emu and ostrich eggs that had been laid at random intervals after mating. eggs were opened, the perivitelline layer overlying the gd region was collected and sperm were visualized with 4',6'-diamidino-2-phenylindole under a fluorescence microscope. to map the distribution of sperm, the gd was divided into six areas (a-f), with a being the centre of the gd and f the area ...	2003	14588183
pathotyping of a newcastle disease virus isolated from emus (dromaius novaehollandiae).		2003	14620583
treating inflammation: some (needless) difficulties for gaining acceptance of effective natural products and traditional medicines.	the quality of so-called 'natural medicines' is extraordinarily variable. lack of resolute pharmacological assays contributes to this hiatus. more stringent evaluation of anti-inflammatory and anti-pyretic activities in rats can help resolve some of the uncertainties surrounding (a) preparations of some herbal products including so-called 'nature's aspirin' (e.g. willowbark, ginger), cat's claw, celery seed, etc., and (b) some animal lipids (e.g. lyprinol(r) (nz mussel), emu and fish oils). thes ...	2003	15035737
antagonism of croton oil inflammation by topical emu oil in cd-1 mice.	emu oil is derived from the emu (dromaius novaehollandiae), which originated in australia, and has been reported to have anti-inflammatory properties. inflammation was induced in anesthetized cd-1 mice by applying 50 microl of 2% croton oil to the inner surface of the left ear. after 2 h, the area was treated with 5 microl of emu, fish, flaxseed, olive, or liquified chicken fat, or left untreated. animals were euthanized at 6 h postapplication of different oils, and earplugs (ep) and plasma samp ...	2003	12934669
heart rate responses to cooling in emu hatchlings.	among fluctuations of instantaneous heart rate (ihr) in newly hatched chicks, heart rate (hr) oscillation with a mean frequency of 0.7 hz has been designated as type ii hr variability characterized by low frequency (lf) oscillation [comp. biochem. physiol. part a 124 (1999) 461]. in response to exposure to lowered ambient temperature (ta), chick hatchlings raised their hr baseline accompanied with the production or augmentation of type ii hr oscillation, indicating that lf oscillation is a pheno ...	2003	12814791
cysticercoids of five species of raillietina fuhrmann, 1920 (cestoda: davaineidae) in ants, pheidole sp., from emu farms in australia.	cysticercoids of five species of raillietina, r. australis (krabbe, 1869) fuhrmann, 1924, r. beveridgei o'callaghan, davies & andrews, 2000, r. chiltoni o'callaghan, davies & andrews, 2000, r. dromaius o'callaghan, davies & andrews, 2000 and r. mitchelli o'callaghan, davies & andrews, 2000, parasitic in the emu dromaius novaehollandiae latham, are described. each species was identified on the basis of the number and size of the rostellar hooks, which correspond to those of adult worms. cysticerc ...	2003	12815212
maturation of cardiovascular control mechanisms in the embryonic emu (dromiceius novaehollandiae).	our understanding of avian embryonic cardiovascular regulation has been based on studies in chickens. the present study was undertaken to determine if the patterns established in chickens are generally applicable to the emu, a ratite bird species. we studied cardiovascular physiology over the interval from 60% to 90% of the emu's 50-day incubation period. during this period, embryonic emus exhibit a slight fall in resting heart rate (from 171 beats min(-1) to 154 beats min(-1)) and a doubling of ...	2003	12819276
epstein-barr virus nuclear antigen-1 and myc cooperate in lymphomagenesis.	the lymphomagenic action of myc genes in conjunction with epstein-barr virus nuclear antigen-1 (ebna-1) have been examined using transgenic mice in several separate tests. synergy between myc and ebna-1 in lymphomagenesis was revealed in a cross breed study where co-expression of transgenic myc and ebna-1 led to a tumor latency period reduced significantly in some crosses. in the resulting bitransgenic tumors, expression of the emu-myc genes was not affected by ebna-1 expression. momlv was utili ...	2003	12845679
neoplastic development in plasma cells.	an increasing number of model systems of plasma cell tumor (pct) formation have been and are being developed. discussed here are six models in mice and multiple myeloma (mm) in humans. each model illustrates a unique set of biological factors. there are two general types of model systems: those that depend upon naturally arising mutagenic changes (pristane-induced pcts, 5tmm, and mm) and those that are associated with oncogenes (emu-v-abl), growth factors [interleukin-6 (il-6)], and anti-apoptot ...	2003	12846815
focal cryogen insults for inducing segmental osteonecrosis: computational and experimental assessments of thermal fields.	orthopaedic management of femoral head osteonecrosis is a common clinical problem for which there presently is no good solution. current animal models are inappropriate to study potential new solutions, since it has been difficult to replicate the natural history of structural collapse seen in the human disorder. recently, progression to collapse was obtained for cryogenically induced osteonecrosis in emus, although the lesions involved were imprecisely controlled in terms of size or location. a ...	2003	12893040
cis-acting regulatory sequences promote high-frequency gene conversion between repeated sequences in mammalian cells.	in mammalian cells, little is known about the nature of recombination-prone regions of the genome. previously, we reported that the immunoglobulin heavy chain (igh) mu locus behaved as a hotspot for mitotic, intrachromosomal gene conversion (gc) between repeated mu constant (cmu) regions in mouse hybridoma cells. to investigate whether elements within the mu gene regulatory region were required for hotspot activity, gene targeting was used to delete a 9.1 kb segment encompassing the mu gene prom ...	2004	15528639
bcl-2 overexpression leads to increases in suppressor of cytokine signaling-3 expression in b cells and de novo follicular lymphoma.	the t(14;18)(q32;q21), resulting in deregulated expression of b-cell-leukemia/lymphoma-2 (bcl-2), represents the genetic hallmark in human follicular lymphomas. substantial evidence supports the hypothesis that the t(14;18) and bcl-2 overexpression are necessary but not solely responsible for neoplastic transformation and require cooperating genetic derangements for neoplastic transformation to occur. to investigate genes that cooperate with bcl-2 to influence cellular signaling pathways importa ...	2004	15561778
[effects of topical emu oil on wound healing in scalded rats].	to observe the effect of topical emu oil on wound healing in scalded rats.	2004	15567771
gene therapy for lysosomal storage diseases: the lessons and promise of animal models.	there are more than 40 different forms of inherited lysosomal storage diseases (lsds) known to occur in humans and the aggregate incidence has been estimated to approach 1 in 7000 live births. most lsds are associated with high morbidity and mortality and represent a significant burden on patients, their families, and health care providers. except for symptomatic therapies, many lsds remain untreatable, and gene therapy is among the only viable treatment options potentially available. therapies ...	2004	15133760
evaluation of magnetic behaviour and in vitro biocompatibility of ferritic pm2000 alloy.	pm2000 is a ferritic alloy obtained by powder metallurgy and is being investigated for potential applications as a biomaterial. this work aimed to assess the biological compatibility and to determine the influence of the processing route and further recrystallisation treatment on the magnetic behaviour. the magnetic behaviour has been analysed as a function of the hysteresis loop obtained by using an inductive method. the biocompatibility has been tested using human osteoblast-like cells seeded ...	2004	15386963
loss of one allele of arf rescues mdm2 haploinsufficiency effects on apoptosis and lymphoma development.	the tumor suppressor p19arf inhibits mdm2, which restricts the activity of p53. complicated feedback and control mechanisms regulate arf, mdm2, and p53 interactions. here we report that arf haploinsufficiency completely rescued the p53-dependent effects of mdm2 haploinsufficiency on b-cell development, survival, and transformation. in contrast to mdm2+/- b cells, mdm2+/- b cells deficient in arf were similar to wild-type b cells in their rates of growth and apoptosis and activation of p53. conse ...	2004	15467748
[preparation and feasibility of superparamagnetic dextran iron oxide nanoparticles as gene carrier].	application of magnetic nano- particles as gene carrier in gene therapy of tumor has developed quickly. to obtain a new type non-viral gene introduction and therapy system,which is convenient,and can drive target gene to express highly and stably,this study was designed to explore the preparation of superparamagnetic dextran iron oxide nanoparticles(sdion),and the feasibility of sdion used as gene carrier in vitro.	2004	15473917
identification of the major proteins of the organic matrix of emu (dromaius novaehollandiae) and rhea (rhea americana) eggshell calcified layer.	1. the eggshell is a composite consisting of 95% calcite and an organic matrix. 2. while many proteins of the chicken eggshell matrix have already been identified, little is known about the matrix of other birds. 3. isolation of the emu and rhea eggshell matrix and analysis of its major constituents showed that the predominant components were c-type lectin-like proteins related to those of ostrich, chicken and goose. 4. serum albumin, vitelline membrane outer layer protein i (vmo-i) and the turp ...	2004	15484722
id2 is dispensable for myc-induced lymphomagenesis.	the emu-myc transgenic mouse appears to be an accurate model of human burkitt's lymphoma that bears myc/immunoglobulin gene translocations. id2, a negative regulator of basic helix-loop-helix transcription factors, has also been proposed as a myc target gene that drives the proliferative response of myc by binding to and overriding the checkpoint functions of the retinoblastoma tumor suppressor protein. targeted deletion of id2 in mice results in defects in b-cell development and prevents the de ...	2004	15492249
the regulated long-term delivery of therapeutic proteins by using antigen-specific b lymphocytes.	memory lymphocytes are important mediators of the immune response. these cells are long-lived and undergo clonal expansion upon reexposure to specific antigen, differentiating into effector cells that secrete ig or cytokines while maintaining a residual pool of memory t and b lymphocytes. here, the ability of antigen-specific lymphocytes to undergo repeated cycles of antigen-driven clonal expansion and contraction is exploited in a therapeutic protocol aimed at regulating protein delivery. the p ...	2004	15520381
targeted overexpression of bcl-xl in b-lymphoid cells results in lymphoproliferative disease and plasma cell malignancies.	multiple myeloma is an incurable malignancy, and there is currently no mouse model that fully recapitulates the development and progression of the disease. we now describe a transgenic mouse that expresses a bcl-xl transgene under the control of the 3'kappa immunoglobulin light chain enhancer, which is most active in murine b cells in late developmental stages. these mice developed nonmalignant plasma cell foci in the bone marrow and soft tissues and hyaline tubular casts in the kidneys. median ...	2004	14656874
high incidence of thymic epithelial tumors in e2f2 transgenic mice.	in virtually all human tumors, genetic and epigenetic alterations have been found which affect the ink4/-cyclin d/rb pathway, which regulates cell cycle entry and exit in normal cells. e2f transcription factors are important downstream components of this pathway, which act by controlling the expression of genes involved in dna replication and cell cycle progression. to determine whether e2f2 deregulation promotes proliferation and tumorigenesis in vivo, we generated e2f2 transgenic mice, in whic ...	2004	14684733
differential emu enhancer activity and expression of bob.1/obf.1, oct2, pu.1, and immunoglobulin in reactive b-cell populations, b-cell non-hodgkin lymphomas, and hodgkin lymphomas.	it has previously been demonstrated that in cultured and in situ tumour cells of classical hodgkin lymphoma (chl), the immunoglobulin (ig) promoter is inactive and its transcription factors oct2 and/or bob.1/obf.1 are down-regulated. in this study, the analysis of these transcription factors has been extended to a broad spectrum of b-cell malignancies and the findings have been related to the situation in normal b-cells of various differentiation stages and to the expression of ig. furthermore, ...	2004	14694522
apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation.	based on experiments with cultured fibroblasts, the apoptosis regulators caspase-9 and apaf-1 are hypothesized to function as tumor suppressors. to investigate their in vivo role in lymphomagenesis, an igh enhancer-driven c-myc transgene was crossed onto apaf-1(-/-) and caspase-9(-/-) mice. due to perinatal lethality, emu-myc transgenic apaf-1(-/-) or caspase-9(-/-) fetal liver cells were used to reconstitute lethally irradiated recipient mice. surprisingly, no differences were seen in rate, inc ...	2004	14709542
osteocyte-based image analysis for quantitation of histologically apparent femoral head osteonecrosis: application to an emu model.	femoral head osteonecrosis is often characterized histologically by the presence of empty lacunae in the affected bony regions. the shape, size and location of a necrotic lesion influences prognosis, and can, in principle, be quantified by mapping the distribution of empty lacunae within a femoral head. an algorithm is here described that automatically identifies the locations of osteocyte-filled vs. empty lacunae. the algorithm is applied to necrotic lesions surgically induced in the emu, a lar ...	2004	14965877
rare beryllium icosahedra in the intermediate valence compound cebe13.	single-crystal x-ray diffraction experiments show that the be atoms in cebe13 form a be12 icosahedra, which is a very unusual structural feature due, in part, to the remarkably low valence electron count of be. magnetization studies show that cebe13 displays intermediate valence behavior, in which valence fluctuations between the ce 4f0 and 4f1 states give rise to enhanced electronic specific heat and magnetic susceptibility. calculations using ab initio theory were used to determine the electro ...	2004	15506745
magnetoswitchable controlled hydrophilicity/hydrophobicity of electrode surfaces using alkyl-chain-functionalized magnetic particles: application for switchable electrochemistry.	magnetic nanoparticles consisting of undecanoate-capped magnetite (average diameter approximately 4.5 nm; saturated magnetization, m(s), 38.5 emu g(-1)) are used to control and switch the hydrophobic or hydrophilic properties of the electrode surface. a two-phase system consisting of an aqueous buffer solution and a toluene phase that includes the suspended capped magnetic nanoparticles is used to control the interfacial properties of the electrode surface. the magnetic attraction of the functio ...	2004	15491206
synthesis of zerovalent nanophase metal particles stabilized with poly(ethylene glycol).	concurrent sonolysis of iron pentacarbonyl and poly(ethylene glycol)-400 (peg-400) in hexadecane solvent proceeds via zero-order kinetics and results in fe nanoparticles encapsulated in peg-400 (fe-peg). the transmission electron microscopy images show fe-peg consisting of <3 nm fe particles that are evenly dispersed in the peg matrix. mössbauer and x-ray absorption fine structure/x-ray absorption near-edge structure data reveal an ordered peg assembly that helps protect the zerovalent fe core. ...	2004	15274601
magnetite-containing spherical silica nanoparticles for biocatalysis and bioseparations.	the simultaneous entrapment of biological macromolecules and nanostructured silica-coated magnetite in sol-gel materials using a reverse-micelle technique leads to a bioactive, mechanically stable, nanometer-sized, and magnetically separable particles. these spherical particles have a typical diameter of 53 +/- 4 nm, a large surface area of 330 m(2)/g, an average pore diameter of 1.5 nm, a total pore volume of 1.427 cm(3)/g and a saturated magnetization (m(s)) of 3.2 emu/g. peroxidase entrapped ...	2004	14987087
syntheses, structures, and physical properties of nickel bis(dithiolene) complexes containing tetrathiafulvalene (ttf) units.	to contribute to the development of single-component molecular metals, several nickel complexes with cyclohexeno-condensed or ethylenedioxy-substituted ttf (tetrathiafulvalene) dithiolate ligands, (r(4)n)(n)[ni(chdt)(2)] [r = me, n = 2 (1); r = (n)bu, n = 1 (2); n = 0 (3)] and (r(4)n)(n)[ni(eodt)(2)] [r = me, n = 2 (4); r = (n)bu, n = 1 (5); n = 0 (6)], were prepared. x-ray structures were determined on the monoanionic species 2 and 5. the tetra-n-butylammonium complex of the monoanionic [ni(chd ...	2004	14753836
molecular paramagnetic semiconductor: crystal structures and magnetic and conducting properties of the ni(dmit)(2) salts of 6-oxoverdazyl radical cations (dmit = 1,3-dithiol-2-thione-4,5-dithiolate).	four kinds of 1:1 and 1:3 salts of 3-[4-(trimethylammonio)phenyl]-1,5-diphenyl-6-oxoverdazyl radical cation ([1](+)) and its mono- and dimethyl derivatives ([2](+) and [3](+)) with ni(dmit)(2) anions (dmit = 1,3-dithiol-2-thione-4,5-dithiolate) ([1](+)[ni(dmit)(2)](-) (4), [2](+)[ni(dmit)(2)](-) (5), [3](+)[ni(dmit)(2)](-) (6), and [1](+)[ni(dmit)(2)](3)(-) (7)) have been prepared, and the magnetic susceptibilities (chi(m)) have been measured between 1.8 and 300 k. the chi(m) values of salts 5 a ...	2004	14731018
identification of angiotensin i in several vertebrate species: its structural and functional evolution.	in order to delineate further the molecular evolution of the renin-angiotensin system in vertebrates, angiotensin i (ang i) has been isolated after incubation of plasma and kidney extracts of emu (dromiceus novaehollandiae), axolotl (ambystoma mexicanum), and sea lamprey (petromyzon marinus). the identified sequences were [asp1, val5, asn9] ang i in emu, [asp1, val5, his9] ang i in axolotl, and [asn1, val5, thr9] ang i in sea lamprey. these results confirmed the previous findings that tetrapods ...	2004	14723880
maternal effects of egg size on emu dromaius novaehollandiae egg composition and hatchling phenotype.	parental investment in eggs and, consequently, in offspring can profoundly influence the phenotype, survival and ultimately evolutionary fitness of an organism. avian eggs are excellent model systems to examine maternal allocation of energy translated through egg size variation. we used the natural range in emu dromaius novaehollandiae egg size, from 400 g to >700 g, to examine the influence of maternal investment in eggs on the morphology and physiology of hatchlings. female emus provisioned la ...	2004	14718503
implementation of a change process to improve outcomes of patients admitted to epilepsy monitoring unit.	a continuous quality improvement in health care, combined with measurement of patient and organizational outcomes, is an international trend that promises improvement in meeting the needs of health care consumers in a cost-effective manner. a clinical improvement workshop was conducted in our institution to study the practical methods that can be used by clinical teams to improve the quality and value of health care. this workshop enabled the epilepsy team to identify change strategies that pote ...	2004	11898300
search for doubly charged higgs bosons decaying to dileptons in pp collisions at square root of s=1.96 tev.	we present the results of a search for doubly charged higgs bosons (h+/-+/-) decaying to dileptons (ll(')) using approximately 240 pb(-1) of pp collision data collected by the cdf ii experiment at the fermilab tevatron. in our search region, given by same-sign ll(') mass m(ll('))>80 gev/c(2) (100 gev/c(2) for ee channel), we observe no evidence for h+/-+/- production. we set limits on sigma(pp -->h++h---->l(+)l('+)l(-)l('-)) as a function of the mass of the h+/-+/- and the chirality of its coupl ...	2004	15601082
from karrawingi the emu to care factor zero. mental health issues in contemporary australian adolescent literature.	to examine the depiction of mental health issues in contemporary australian adolescent literature. this material might influence teenagers' understanding of mental illness and their willingness to seek help, and may provide insights into societal attitudes towards adolescents and the psychiatric problems encountered in this age group.	2004	11379510
etiology and epidemiology of verminous encephalitis in an emu.		2004	7103894
encephalomalacia associated with vitamin e deficiency in commercially raised emus.	thirteen of 64 emus on a commercial emu farm in ohio exhibited neurological signs that included backward staggering, incoordination, generalized weakness, and sitting on their hocks with head retracted backward. eight of the birds showing such signs were found dead. two of these emus were necropsied, and no significant gross lesions were observed. major histopathological lesions were found in the cerebellum and included multiple malacic foci in association with neuropil rarefaction and astroglio ...	2004	9777163
preparation of ferrimagnetic magnetite microspheres for in situ hyperthermic treatment of cancer.	ferrimagnetic microspheres 20-30 microm in diameter are useful as thermoseeds for inducing hyperthermia in cancers, especially for tumors located deep inside the body. the microspheres are entrapped in the capillary bed of the tumors when they are implanted through blood vessels and heat cancers locally by their hysteresis loss when placed under an alternating magnetic field. in the present study, preparation of magnetite (fe(3)o(4)) microspheres 20-30 microm in diameter was attempted by melting ...	2005	15585224
successful initiation of combined therapy with valproate sodium injection and divalproex sodium extended-release tablets in the epilepsy monitoring unit.	patients in epilepsy monitoring units (emus) often require aggressive initiation or reinitiation of therapy before discharge. we developed a simple dosing scheme using valproate sodium injection (vpa-iv) and divalproex sodium extended-release (vpa-er) tablets to minimize the time required for initiation of therapy, without increasing the likelihood of seizures and adverse effects.	2005	15946337
measurement of the ww production cross section in pp collisions at square root[s]=1.96 tev.	we present a measurement of the w boson pair-production cross section in pp collisions at a center-of-mass energy of sqrt[s]=1.96 tev. the data, collected with the run ii d0 detector at fermilab, correspond to an integrated luminosity of 224-252 pb(-1) depending on the final state (ee, emu, or mumu). we observe 25 candidates with a background expectation of 8.1+/-0.6(stat)+/-0.6(syst)+/-0.5(lum) events. the probability for an upward fluctuation of the background to produce the observed signal is ...	2005	15904132
mechanical counter-pressure vs. gas-pressurized spacesuit gloves: grip and sensitivity.	an elastic mechanical counter pressure (mcp) glove for spacesuits is under development. in this study we compared handgrip and pinch grip strength levels for the mcp glove and the current extravehicular mobility unit (emu) gas-pressurized glove.	2005	15828639
preparation and solid-state characterization of the novel mixed biradical nsnsc-cnssn.	reduction of the radical-cation [nssnc-cnsns][asf(6)] with ferrocene affords the novel biradical nsnsc-cnssn* containing both 1,2,3,5- and 1,3,2,4-isomeric dithiadiazolyl rings. biradicals form centrosymmetric dimers with pi()-pi() interactions between different isomeric rings. biradical nsnsc-cnssn is diamagnetic in the solid state (c = 0.00035, tip = 6.5 x 10(-)(5) emu/oe.mol); however, an increase in paramagnetism was observed upon grinding (c = 0.003, tip = 4.2 x 10(-)(4) emu/oe.mol).	2005	15819539
evolution of transcriptional enhancers in the immunoglobulin heavy-chain gene: functional characteristics of the zebrafish emu3' enhancer.	past studies of the channel catfish immunoglobulin heavy-chain (igh) locus indicates that it lacks an emu enhancer in the j(h)-cmu1 intron but does have an enhancer, termed emu3', in the mu-delta intergenic region. the positioning of the catfish enhancer downstream of the mu-chain exons is predicted to be unfavorable for antibody-affinity maturation in catfish, and would also have been an impediment to the evolution of class switch recombination, had it existed in early tetrapods. to determine i ...	2005	15756545
ferromagnetic ordering of fe(iii) d spins of febr4- ions in (ethylenedithiotetrathiafulvalenothioquinone-ethylenedithio-1,3-dithiolemethide) x febr4.	the 1:1 salt of a new donor molecule, ethylenedithiotetrathiafulvalenothioquinone-ethylenedithio-1,3-dithiolemethide (1), with febr4- ion, 1 x febr4, was prepared and found to exhibit a room-temperature electrical conductivity of 4 x 10(-2) s cm(-1) and semiconducting behavior with an activation energy of 170 mev. the paramagnetic susceptibility obeyed the curie-weiss law with a curie constant of 4.42 emu k mol(-1) and a weiss temperature of +3.4 k, and below 15 k, this short-range ferromagnetic ...	2005	15732952
synthesis, structure, and magnetism of a 1d compound engineered from a biradical [5,5'-bis(3''-oxide-1''-oxyl-4'',4'',5'',5''-tetramethylimidazolin-2''-yl)-2,2'-bipyridine] and mn(ii)(hfac)2.	the synthesis, crystal structure, and magnetic properties of a one-dimensional compound, {[mn(hfac)2]2(biradical)}n (1), resulting from the coordination of bis(hexafluoroacethylacetonato)manganese(ii) [mn(hfac)2] with a biradical obtained by grafting two nitronyl nitroxide radicals in the 5 and 5' positions of a 2,2'-bipyridine ligand are described. compound 1 crystallizes in the triclinic p space group with the following parameters: a = 11.905(2) a, b = 12.911(2) a, c = 20.163(3) a, alpha = 73. ...	2005	15679395
high magnetization and the high-temperature superparamagnetic transition with intercluster interaction in disordered zinc ferrite thin film.	magnetic properties have been investigated for a zinc ferrite thin film deposited on glass at a substrate temperature close to room temperature using a sputtering method. x-ray diffraction analysis reveals that the thin film consists of nanocrystalline znfe(2)o(4) with the size of approximately 10 nm. the magnetization at 300 k as a function of the external magnetic field shows ferrimagnetic behaviour, and tends to be saturated to the high value of 32 emu g(-1) when the external magnetic field i ...	2005	21690674
combining perimetric suprathreshold and threshold procedures to reduce measurement variability in areas of visual field loss.	several current perimetric test strategies use information from neighboring test locations to seed the procedure. when this initial estimate is close to the true threshold, the algorithms terminate quickly with low error. however, when neighboring thresholds are dissimilar, seeding procedures in this manner results in poor accuracy and repeatability. this study aims to develop a test procedure that avoids assumptions based on neighboring locations yet terminates with an acceptable number of pres ...	2005	15630403
structure and magnetic properties of (meso-tetraphenylporphinato)manganese(iii) bis(dithiolato)nickelates.	the crystal structures of [mntpp]{ni[s2c2h(cn)]2} [mntpp = (meso-tetraphenylporphinato)manganese(iii)] and [mntpp]{ni[s2c2(cn)2]2} have been determined. these salts possess trans-mu-coordination of s = 1/2 {ni[s2c2h(cn)]2}- and {ni[s(2)c(2)(cn)(2)](2)}- to mn(iii) and form parallel 1-d coordination polymer chains exhibiting nu(cn) at 2210 and 2200 and 2220 and 2212 cm(-1), respectively. the bis(dithiolato) monoanions are planar and bridge two cations with mnn distances of 2.339(16), and 2.394( ...	2005	16212379
deposition feature of ni nanoparticles on halloysite template and magnetic properties of the composite.	a novel cermet composite with ni nanoparticles deposited on a hollow cylindrical halloysite template is fabricated by electroless plating. ni nanoparticles have a uniform distribution on the template, and their average diameter is mainly in the range of 20-30 nm. the halloysite template will be beneficial to make the ni nanoparticles achieve high stability and well-dispersed state. different heat treatment temperatures have a great effect on the crystal structure of ni nanoparticles and the magn ...	2005	16108436
complex regulation of somatic hypermutation by cis-acting sequences in the endogenous igh gene in hybridoma cells.	to create high-affinity antibodies, b cells target a high rate of somatic hypermutation (shm) to the ig variable-region genes that encode the antigen-binding site. this mutational process requires transcription and is triggered by activation-induced cytidine deaminase (aid), which converts deoxycytidine to deoxyuridine. mistargeting of aid to non-ig genes is thought to result in the malignant transformation of b cells, but the mechanism responsible for targeting shm to certain dna regions and no ...	2005	16087866
fe3o4 nanocrystals with novel fractal.	fe3o4 novel fractal nanocrystals have been synthesized by a surfactant-assisted solvothermal process for the first time. x-ray diffraction (xrd), x-ray photoelectron spectra (xps), mössbauer spectroscopy (ms), scanning electron microscopy (sem), and transmission electron microscopy (tem) have been used to investigate the novel fractal nanocrystals. the lengths of the fractals are about 2-3 microm, and the trunks and branches of fe3o4 fractals have almost the same diameters of ca. 30-50 nm. the r ...	2005	16853363
anomalous magnetic properties of mechanically milled cobalt oxide nanoparticles.	defect induced magnetic properties of coo nanoparticles produced via mechanical ball milling have been assessed by detailed magnetic measurements. a progressive decrease in the particle size and a concomitant increase in the induced strain have been observed with the milling times. the mechanically milled nanoparticles of coo exhibit anomalous magnetic properties such as fm hysteresis when compared with the unmilled coo sample. the presence of weak ferromagnetism, with a highest value of magneti ...	2005	16430143
synthesis, structure, and magnetic ordering of layered (2-d) v-based tris(oxalato)metalates.	the reaction of k3[m(iii)(ox)3].3h2o [m = v (1), cr; ox = oxalate], mn(ii)/v(ii), and [n(n-bu)4]br in water leads to the isolation of 2-d v-based coordination polymers, [[n(n-bu)4][mn(ii)v(iii)(ox)3]]n (2), [[n(n-bu)4][v(ii)cr(iii)(ox)3]]n (3), [[n(n-bu)4][v(ii)v(iii)(ox)3]]n (4), and an intermediate in the formation of 4, [[n(n-bu)4][v(ii)v(iii)(ox)3(h2o)2]]n.2.5h2o (4a), while 1-d [v(ii)(ox)(h2o)2]n (5) is obtained by using na2ox and [v(oh2)6]so4 in water. the structures of 1-5 have been inves ...	2005	16270982
deregulated expression of the myc cellular oncogene drives development of mouse "burkitt-like" lymphomas from naive b cells.	chromosomal translocations juxtaposing immunoglobulin (ig) and myc genes are the hallmarks of human burkitt lymphoma (bl), with deregulated myc expression being a critical factor in pathogenesis. by inserting an intact mouse myc gene into the mouse genome, proximal to the ig enhancer emu, the effect of a precise mimic of the major t(8;14) translocation of human endemic bl (ebl) could be investigated. knock-in mice developed igm-positive b-cell tumors, with most being typical of ebl by histology ...	2005	15522957
biodesulfurization using pseudomonas delafieldii in magnetic polyvinyl alcohol beads.	to immobilize pseudomonas delafieldii r-8 cells in magnetic polyvinyl alcohol (pva) beads for biodesulfurization.	2005	15612999
[effects of emu eggshell on sexual function of male mice].	to investigate the effects of emu (dromaius novaehollandiae) eggshell produced in guangdong on sexual ability of male mice.	2005	15699007
mdm2 splice variants and their therapeutic implications.	mdm2 splice variants have now been identified in many different tumor types, and their expression has been associated with advanced disease. however, published data concerning their function is contradictory, and therefore their role in tumorigenesis and their potential as a therapeutic target are unclear. expression of a specific splice variant, mdm2-b, in a transgenic mouse model results in tumor development; and expression of several splice variants has been shown to enhance tumor formation i ...	2005	15720186
insertion of c-myc into igh induces b-cell and plasma-cell neoplasms in mice.	we used gene targeting in mice to insert a his(6)-tagged mouse c-myc cdna, myc(his), head to head into the mouse immunoglobulin heavy-chain locus, igh, just 5' of the intronic enhancer, emu. the insertion of myc(his) mimicked both the human t(8;14)(q24;q32) translocation that results in the activation of myc in human endemic burkitt lymphomas and the homologous mouse t(12;15) translocation that deregulates myc in certain mouse plasmacytomas. beginning at the age of 6 months, myc(his) transgenic ...	2005	15735016
the novel ets factor tel2 cooperates with myc in b lymphomagenesis.	the human ets family gene tel2/etv7 is highly homologous to tel1/etv6, a frequent target of chromosome translocations in human leukemia and specific solid tumors. here we report that tel2 augments the proliferation and survival of normal mouse b cells and dramatically accelerates lymphoma development in emu-myc transgenic mice. nonetheless, inactivation of the p53 pathway was a hallmark of all tel2/emu-myc lymphomas, indicating that tel2 expression alone is insufficient to bypass this apoptotic ...	2005	15743832
histone deacetylase inhibitor trichostatin a reduces anti-dna autoantibody production and represses igh gene transcription.	systemic lupus erythematosus is characterized by the presence of autoantibodies and hypergammaglobulinemia. to investigate the role of histone deacetylases (hdacs) in the production of autoantibody and immunoglobulin, we examined the effect of trichostatin a (tsa), a specific inhibitor of hdacs, on anti-dna autoantibody production and igh gene transcription. our results showed that inhibition of hdac activity by tsa markedly reduced anti-dna autoantibody production by t347 cells either by induci ...	2005	15781251
recurrent chromosomal aberrations in ink4a/arf defective primary lymphomas predict drug responses in vivo.	predicting responsiveness to anticancer therapy based on molecular findings at diagnosis is important to optimize treatment decisions. although clinical outcome correlates with distinct mutations in some cancer entities, treatment responses within these lesion-stratified subgroups still remain heterogeneous, underscoring the need for additional prognosticators. we previously demonstrated that defined genetic defects at the ink4a/arf locus, which encodes the tumor suppressors p16ink4a and arf, no ...	2005	15824738
second intermediate host land snails and definitive host animals of brachylaima cribbi in southern australia.	this study of infection of southern australian land snails with brachylaima cribbi metacercariae has shown that all commonly encountered native and introduced snails are susceptible second intermediate hosts. the range of infected snails is extensive with metacercariae-infected snails being present in all districts across southern australia. c. virgata has the highest average natural metacercarial infection intensity of 6.1 metacercariae per infected snail. the susceptibility of birds, mammals a ...	2005	15828579
[anti-inflammatory activity and healing-promoting effects of topical application of emu oil on wound in scalded rats].	to investigate the effects of topical application of emu oil on wound healing in scalded rats.	2005	15837639
nfkb 1 is dispensable for myc-induced lymphomagenesis.	rel/nf-kappab transcription factors are critical arbiters of immune responses, cell survival, and transformation, and are frequently deregulated in cancer. the p50 nf-kappab 1 component of rel/nf-kappab dna-binding dimers regulates genes involved in both cell cycle traverse and apoptosis. nfkb 1 loss accelerates b cell growth and leads to increased b cell turnover in vivo, phenotypes akin to those manifested in b cells of emu-myc transgenic mice, a model of human burkitt lymphoma. interestingly, ...	2005	15940251
mif loss impairs myc-induced lymphomagenesis.	macrophage migration inhibitory factor (mif) is a potent regulator of inflammation and cell growth. using the emu-myc lymphoma mouse model, we demonstrate that loss of mif markedly delays the onset of b-cell lymphoma development in vivo. the molecular basis for this mif-loss-induced phenotype is the perturbed dna-binding activity of e2f factors and the concomitantly enhanced tumor suppressor activity of the p53 pathway. accordingly, premalignant mif-null emu-myc b-cells are predisposed to delaye ...	2005	15947793
therapeutically promising pna complementary to a regulatory sequence for c-myc: pharmacokinetics in an animal model of human burkitt's lymphoma.	in burkitt's lymphoma (bl) cells c-myc is often translocated in proximity to the emu enhancer of the ig gene locus. this translocation causes c-myc hyperexpression and an increase in the cells' proliferative capacity. a peptide nucleic acid (pna) complementary to enhancer emu intronic sequence (pnaemu), linked to a nuclear localization signal (nls), selectively and specifically blocks the expression of the c-myc oncogene under emu control in vitro, suggesting potential therapeutic use. to explor ...	2005	15989423
ecosystem collapse in pleistocene australia and a human role in megafaunal extinction.	most of australia's largest mammals became extinct 50,000 to 45,000 years ago, shortly after humans colonized the continent. without exceptional climate change at that time, a human cause is inferred, but a mechanism remains elusive. a 140,000-year record of dietary delta(13)c documents a permanent reduction in food sources available to the australian emu, beginning about the time of human colonization; a change replicated at three widely separated sites and in the marsupial wombat. we speculate ...	2005	16002615
biocompatible and biodegradable polymer nanofibers displaying superparamagnetic properties.	superparamagnetic polymer nanofibers intended for drug delivery and therapy are considered here. magnetite (fe3o4) nanoparticles in the diameter range of 5-10 nm were synthesized in aqueous solution. polymer nanofibers containing magnetite nanoparticles were prepared from commercially available poly(hydroxyethyl methacrylate), phema, and poly-l-lactide (plla) by the electrospinning technique. nanofibers with diameters ranging from 50 to 300 nm were obtained. nanofibers containing up to 35 wt % m ...	2005	16007710
synthesis of magnetic chelator for high-capacity immobilized metal affinity adsorption of protein by cerium initiated graft polymerization.	a novel magnetic chelator with high adsorption capacity of protein by immobilized metal affinity adsorption was prepared by cerium (iv) initiated graft polymerization of tentacle-type polymer chains with iminodiacetic acid (ida) chelating group on magnetic particles with hydroxyl groups. the micron-sized magnetic poly(vinyl acetate-divinylbenzene) (pvac-dvb) particles were prepared by a modified suspension polymerization in the presence of oleic acid-coated magnetite nanoparticles and subsequent ...	2005	16008413
biodesulfurization of dibenzothiophene by microbial cells coated with magnetite nanoparticles.	microbial cells of pseudomonas delafieldii were coated with magnetic fe3o4 nanoparticles and then immobilized by external application of a magnetic field. magnetic fe3o4 nanoparticles were synthesized by a coprecipitation method followed by modification with ammonium oleate. the surface-modified fe3o4 nanoparticles were monodispersed in an aqueous solution and did not precipitate in over 18 months. using transmission electron microscopy (tem), the average size of the magnetic particles was found ...	2005	16085841
insertion of myc into igh accelerates peritoneal plasmacytomas in mice.	gene-targeted mice that contain a his6-tagged mouse c-myc cdna, myc(his), inserted head to head into different sites of the mouse immunoglobulin heavy-chain locus, igh, mimic the chromosomal t(12;15)(igh-myc) translocation that results in the activation of myc in the great majority of mouse plasmacytomas. mice carrying myc(his) just 5' of the intronic heavy-chain enhancer emu (strain imyc(emu)) provide a specific model of the type of t(12;15) found in a subset (approximately 20%) of plasmacytoma ...	2005	16140930
chondroconductive potential of tantalum trabecular metal.	mesenchymal stem cells or chondrocytes have been implanted into joints in biodegradable matrices in order to improve the quality of healing cartilage defects; however, insufficient biomechanical strength of the construct at implantation is a limiting factor for clinical application. logically, a construct with better biomechanical characteristics would provide better results. tantalum trabecular metal (ttm) is osteoconductive and mechanically similar to subchondral bone. the objective of this pi ...	2005	16161110
seizures in the elderly: video/eeg monitoring analysis.	recently there has been a remarkable increase in the number of elderly people with epilepsy due to the growing size of this segment of the population. the literature provides little information on the characteristics of epileptic and nonepileptic events in the elderly. therefore we report the results of video/eeg recordings in patients aged 60 or older admitted over 2 consecutive years to an epilepsy monitoring unit (emu).	2005	16165402
complex biallelic igh rearrangements in igm-expressing z-138 cell line: involvement of downstream immunoglobulin class switch recombination.	chromosomal translocations involving the immunoglobulin (ig) receptor loci usually disrupt and silence these loci. on the basis of observations in follicular lymphoma (fl) with downstream ig heavy chain (igh) class switch recombination (csr), we hypothesized that downstream csr-mediated chromosomal translocations would leave the v(d)j-cmu transcription unit intact, thereby still allowing igm expression from the igh allele involved in the translocation. to test this hypothesis, we analyzed bialle ...	2005	15543623
ccaat/enhancer binding protein alpha (c/ebpalpha) and c/ebpalpha myeloid oncoproteins induce bcl-2 via interaction of their basic regions with nuclear factor-kappab p50.	the cebpa gene is mutated in 10% of acute myeloid leukemia (aml) cases. we find that cebpa and bcl-2 rna levels correlate highly in low-risk human amls, suggesting that inhibition of apoptosis via induction of bcl-2 by ccaat/enhancer binding protein alpha (c/ebpalpha) or its mutant variants contributes to transformation. c/ebpalphap30, lacking a nh2-terminal transactivation domain, or c/ebpalphalz, carrying in-frame mutations in the leucine zipper that prevent dna binding, induced bcl-2 in hemat ...	2005	16254192
mitochondrially targeted p53 has tumor suppressor activities in vivo.	complex proapoptotic functions are essential for the tumor suppressor activity of p53. we recently described a novel transcription-independent mechanism that involves a rapid proapoptotic action of p53 at the mitochondria and executes the shortest known circuitry of p53 death signaling. here, we examine if this p53-dependent mitochondrial program could be exploited for tumor suppression in vivo. to test this, we engage emu-myc transgenic mice, a well-established model of p53-dependent lymphomage ...	2005	16267022
molecular and cytological features of the mouse b-cell lymphoma line imycemu-1.	myc-induced lymphoblastic b-cell lymphoma (lbl) in imycemu mice may provide a model system for the study of the mechanism by which human myc facilitates the initiation and progression of b cell and plasma cell neoplasms in human beings. we have recently shown that gene-targeted imycemu mice that carry a his6-tagged mouse myc cdna, mychis, just 5' of the immunoglobulin heavy-chain enhancer, emu, are prone to b cell and plasma cell tumors. the predominant tumor (approximately 50%) that arose in th ...	2005	16277667
in vivo bone strain and ontogenetic growth patterns in relation to life-history strategies and performance in two vertebrate taxa: goats and emu.	this study examined ontogenetic patterns of limb loading, bone strains, and relative changes in bone geometry to explore the relationship between in vivo mechanics and size-related changes in the limb skeleton of two vertebrate taxa. despite maintaining similar relative limb loads during ontogeny, bone strain magnitudes in the goat radius and emu tibiotarsus generally increased. however, while the strain increases in the emu tibiotarsus were mostly insignificant, strains within the radii of adul ...	2006	16380928
amino acid sequences and phosphorylation sites of emu and rhea eggshell c-type lectin-like proteins.	avian calcified eggshell layers contain in their organic matrix one or two c-type lectin-like proteins. previously characterized eggshell proteins of this family are chicken ovocleidin-17 (oc-17), goose ansocalcin and ostrich struthiocalcins 1 and 2 (sca-1, sca-2). in this report we present the amino acid sequences of two emu (dromaius novaehollandiae) (dromaiocalcin-1 and -2; dca-1, dca-2) and of two rhea (rhea americana) (rheacalcin-1 and -2; rca-1, rca-2) c-type lectin-like eggshell proteins, ...	2006	16403478
effect of rapamycin on mouse chronic lymphocytic leukemia and the development of nonhematopoietic malignancies in emu-tcl1 transgenic mice.	chronic lymphocytic leukemia (cll) is the most common leukemia in the world. the tcl1 gene, responsible for prolymphocytic t cell leukemia, is also overexpressed in human b cell malignancies and overexpression of the tcl1 protein occurs frequently in cll. aging transgenic mice that overexpress tcl1 under control of the mu immunoglobulin gene enhancer, develop a cd5+ b cell lymphoproliferative disorder mimicking human cll and implicating tcl1 in the pathogenesis of cll. in the current study, we e ...	2006	16424025
interaural timing difference circuits in the auditory brainstem of the emu (dromaius novaehollandiae).	in the auditory system, precise encoding of temporal information is critical for sound localization, a task with direct behavioral relevance. interaural timing differences (itds) are computed using axonal delay lines and cellular coincidence detectors in nucleus laminaris (nl). we present morphological and physiological data on the timing circuits in the emu, dromaius novaehollandiae, and compare these results with those from the barn owl (tyto alba) and the domestic chick (gallus gallus). emu n ...	2006	16435285
regulation of igh gene assembly: role of the intronic enhancer and 5'dq52 region in targeting dhjh recombination.	the assembly of ag receptor genes by v(d)j recombination is regulated by transcriptional promoters and enhancers which control chromatin accessibility at ig and tcr gene segments to the rag-1/rag-2 recombinase complex. paradoxically, germline deletions of the igh enhancer (emu) only modestly reduce d(h)-->j(h) rearrangements when assessed in peripheral b cells. however, deletion of emu severely impairs recombination of v(h) gene segments, which are located over 100 kb away. we now test two alter ...	2006	16456003