Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| experimental toxocara canis infection in cynomolgus macaques (macaca fascicularis). | visceral larva migrans was produced in 16 cynomolgus macaques (macaca fascicularis) experimentally inoculated with 45,000 embryonated eggs of toxocara canis as a single bolus or in 3 divided doses. the hematologic and serologic changes were similar to those observed in children with visceral toxocara infection. neurologic signs developed in 3 animals and were characterized by ataxia and nystagmus. growth rates were diminished in inoculated animals when compared with the rates in noninoculated co ... | 1983 | 6660626 |
| the effect of toxocara canis infection on the behaviour of mice. | 1983 | 6660962 | |
| [larval toxocariasis in a 40-year-old man with detection of larvae in a liver biopsy]. | a 40-year old cattle feeder has been suffering from indigestion, leukocytosis and conspicuous eosinophilia for about 4 years. a sample of liver tissue was taken during gastrectomy and multiple allergic granulomas rich in eosinophilia leukocytes were found. toxocara canis was identified in serial sections outside the granulomas. larval toxocariasis was confirmed by a high level of specific antibodies which failed to decrease even after administration of mintezol antithelmintic. in this country, t ... | 1983 | 6661784 |
| some observations on the experimental infection of white mice with toxocara canis. | 1983 | 6663101 | |
| the iga antibody activities in relation to the parasitologic status of toxocara canis in dogs. | in this study, the relationship between the iga antibody activities to toxocara canis infection in dogs and their parasitologic status has been examined. the enzyme-linked immunosorbent assay was applied to the sera of dogs for the detection of the specific iga antibodies and at the same time, autopsy and stool examination were performed on these dogs. the most elevated iga antibody levels were observed in the one-month age group of puppies. thereafter, the levels gradually decreased until six a ... | 1983 | 6673418 |
| preliminary study on the follow-up observations of the antibodies and circulating antigens in canine toxocariasis. | in the sera of dog fetuses and newborn puppies, no antibody to toxocara canis was found but an elevation of the circulating toxocaral antigens (cta). in the mother dogs, detectable igg and igm antibodies were found. the igg antibodies gradually increased in the course of this observation. the most elevated levels of iga antibodies were observed one month after birth. the same was true for the cta levels. there was no placental transfer of the antibodies nor could they be transferred from the mot ... | 1983 | 6673419 |
| the measurement of ascaris suum protein by radioimmunoassay in sera from patients with helminthiasis and with gastrointestinal diseases. | in this study, we have developed a reliable radioimmunoassay (ria) for ascaris suum protein (asp) and have measured the serum concentration of asp in control subjects and in patients with helminthiasis and a variety of gastrointestinal diseases. the cross-reactivities of asp antibody with other helminth worm antigens were also measured by ria. ascaris lumbricoides contained approximately the same amount of asp antigenic substance as did ascaris suum. toxocara canis had a high concentration of a ... | 1983 | 6682964 |
| activation of complement in c-reactive protein positive sera by phosphorylcholine-bearing component isolated from parasite extract. | phosphorylcholine-bearing component levels in extracts of various parasites were determined by a capillary precipitin test using anti-phosphorylcholine ig a myeloma protein. tepc-15. phosphorylcholine was demonstrated as a structural component not only in nematodes but also in trematodes and cestodes. the phosphorylcholine-bearing component was isolated from an extract of toxocara canis larvae using a tepc-15-sepharose 4b column. the component reacted with c-reactive protein in sera to form one ... | 1983 | 6684760 |
| fenbendazole treatment of pregnant bitches to reduce prenatal and lactogenic infections of toxocara canis and ancylostoma caninum in pups. | a granulated formulation of fenbendazole was tested in a total of 23 treated and control, pregnant, parasite-free beagle bitches experimentally infected with toxocara canis and ancylostoma caninum. the drug was administered to each treated bitch once daily in canned dog food at a dosage of 50 mg/kg body weight. each of 2 treatment regimens tested was initiated on the 40th day of pregnancy. one regimen involved daily treatment continuing through the 14th postpartum day, and it resulted in 89% few ... | 1983 | 12002591 |
| experimental ocular toxocariasis: a mouse model. | male mice, strain c57 black, were infected with toxocara canis by a single intragastric dose of 1500 infective eggs. the eyes were studied at sequential time periods after infection (6 to 63 days) by conventional microscopic techniques, and the histological characteristics of the inflammatory response were recorded. in the majority of animals the disease was unilateral. twenty-six larvae were found in the retina, in the retinal vessels, and in the subretinal space in 20 eyes, while in 29 eyes th ... | 1984 | 6691961 |
| toxocara canis infection of the eye. correlation of clinical observations with developing pathology in the primate model. | a primate model for the study of toxocara canis infection was created by intravitreal, periocular, systemic, and intracarotid injection of viable larvae in cynomolgus monkeys. the results were as follows: (1) intravitreal larvae caused retinal hemorrhages, perivasculitis, mild vitritis, and retinal nodules. (2) apparently viable larvae without inflammatory reaction were found in the vitreous, retina, and optic nerves up to nine months after intravitreal inoculation. (3) other larvae were surroun ... | 1984 | 6696677 |
| characterization of surface and excretory-secretory antigens of toxocara canis infective larvae. | the surface antigens of toxocara canis infective larvae have been identified by radio-iodination and compared with the excretory-secretory (es) products released by the larvae in vitro. common antigens, of molecular weight 32 000 and 120 000 are found on the larval surface, in the es material and in culture supernatant following surface iodination of living t. canis larvae. the 120 000 antigens consist of three closely migrating bands in each of these preparations. however, one prominent es comp ... | 1984 | 6701003 |
| anthelmintic effect of febantel/praziquantel paste in dogs and cats. | a paste formulation of 3.4% febantel and 0.34% praziquantel was given in soft food at a rate of 0.29 g/kg of body weight, once daily for 3 days to dogs and cats. eleven of 12 dogs were naturally infected with ancylostoma caninum, 10 with trichuris vulpis, 2 with toxocara canis, 5 with taenia sp, and 3 with dirofilaria immitis. ten of 11 cats were naturally infected with toxocara cati, 2 with ancylostoma tubaeforme, 3 with taenia sp, 5 with capillaria aerophila, and 1 with paragonimus kellicotti. ... | 1984 | 6703448 |
| toxocara canis infection: clinical and epidemiological associations with seropositivity in kindergarten children. | to determine epidemiological and clinical associations with toxocara canis seropositivity, we studied 333 (87%) children of a cohort of 383 five- to seven-year-olds. the prevalence of seropositivity (antibody titer to t canis, greater than or equal to 1:32) was 23.1%. black children were more frequently seropositive than were white children, as were children of parents who did not graduate from high school. in a sample of seropositive and seronegative children, seropositivity was associated with ... | 1984 | 6725991 |
| metazoan parasites of dogs in sabah, malaysia. | the parasites which occurred most frequently in 175 owned or stray dogs in sabah were ancylostoma spp. present in 68% of the animals. dirofilaria immitis occurred in 70% of the adult dogs but neither d. immitis nor spirocerca lupi were present in puppies under four months of age. the latter attained a prevalence of 30% in the adults. in contrast toxocara canis occurred in 81% of the puppies but infrequently in older dogs. dipylidium caninum was moderately prevalent (15 to 25%) in dogs of all age ... | 1984 | 6730003 |
| helminth parasites of wild foxes (vulpes vulpes l.) in the netherlands. | to study the helminth fauna of wild foxes (vulpes vulpes) in the netherlands, material was collected from 139 foxes. the following parasites were found. cestodes: taenia spp. 53.3%, hymenolepis spp. 1.5%; trematodes: alaria alata 10.9%, cryptocotyle lingua 3.6%, euparyphium melis 1.5%, apophallus donicus 0.7%; nematodes: toxocara canis 73.7%, uncinaria stenocephala 59.9%, capillaria aerophila 46.8%, c. plica 23.5%, molineus patens 5.1%, crenosoma vulpis 4.5%, strongyloides spp. 0.7%. the tapewor ... | 1984 | 6741217 |
| toxocara antigen and mitogen-induced lymphocyte blastogenesis for diagnosis of visceral larva migrans: clinical and experimental findings in macaques and human beings. | peripheral lymphocytes from macaques inoculated with toxocara canis and from children with serologically confirmed visceral larva migrans (vlm) were assayed for blastogenic responses using toxocara antigen and standard mitogens. macaques were given single or multiple larval infections. lymphocyte responses of inoculated macaques were compared with responses from noninoculated macaques. similarly, lymphocyte responses from 2 serologically confirmed human toxocara vlm patients were compared with t ... | 1984 | 6742587 |
| [ocular toxocariasis. diagnostic and therapeutic attainments]. | toxocara canis is nematode parasite of dogs. children are particularly subject to infestation, however the larva remains quiescent at stage ii. toxocara can localize in the eye and induce a variety of clinical manifestations. a case of ocular toxocara is presented in which there was granulomatous endophthalmitis. immunologic testing was negative in the serum but positive in the vitreous, where numerous eosinophils and plasma cells where found. vitreous and aqueous ige levels were elevated. corti ... | 1984 | 6747214 |
| toxocara canis infection in dogs in beersheba, israel. | in the desert city of beersheba, israel, a survey was made of the infection rate of toxocara canis in dogs. 3.0% of dogs destroyed at the municipal dog pound had intestinal t. canis. 7% of faecal samples gathered from day care centres throughout the city were shown to contain t. canis eggs. this low rate of infection could possibly be explained by the hot, arid climatic conditions which may render eggs non-infective or by the sandy soil in the area that may cover faeces containing t. canis ova a ... | 1984 | 6747256 |
| induction of peripheral blood eosinophilia in mice by excretory and secretory antigen of toxocara canis larvae. | medium in which t. canis larvae had been cultured was applied to a sephadex g-25 gel column and four fractions (fr. 1-fr. 4) were isolated. each fraction was administered to mice by implanting a mini-osmotic pump into the peritoneal cavity and the subsequent peripheral blood eosinophilic counts were recorded. mice given fr. 1 showed a markedly greater eosinophilic response than did those given the other fractions. complement activation by each fraction was investigated using normal human serum. ... | 1984 | 6747257 |
| comparison of counterimmunoelectrophoresis with indirect haemagglutination test in the detection of antibodies in rabbits experimentally infected with various species of ascarids. | counterimmunoelectrophoresis (ciep) and indirect haemagglutination (iha) were used for the detection of antibodies in 437 sera of rabbits experimentally infected with ascaris suum, toxocara canis and toxascaris leonina. ciep showed 44.0-52.3% positivity in a. suum, 25.5% in t. canis and 19.7-29.2% in t. leonina infection, whereas the positivity detected by iha was 59.8-90.2% in a. suum, 44.8% in t. canis and 59.6% in t. leonina infection. a comparison of the two tests reveals that ciep is a suit ... | 1984 | 6589203 |
| interrelationship of eosinophilia and ige antibody production to larval es antigen in toxocara canis infected mice. | in order to elucidate the relationship between eosinophilia and ige antibody production in parasitic infection, the degree of eosinophilia and ige antibody levels to larval es antigen of toxocara canis were investigated in eight inbred strains of mice after infection with t. canis. eosinophilia was far higher in degree in sjl mice than in the other inbred strains. however, ige antibody levels to larval es antigen in sjl mice were the lowest among those inbred strains. similarly, the degree of eo ... | 1984 | 6438599 |
| detection of circulating toxocaral antigens in dogs by sandwich enzyme-immunoassay. | this study describes the presence of circulating toxocaral antigens (cta) in the sera of dogs infected with toxocara canis (t. canis) by using a sandwich enzyme-immunoassay (seia). a specificity of this assay with different antigens was observed, i.e. the eia values, which express the antigen concentration, of excretory-secretory antigen from t. canis larvae were higher than those of other antigens (ascaris lumbricoides, dirofilaria immitis and fasciola hepatica). the variability in intra-assay ... | 1984 | 6365746 |
| spleen cell responses in experimental murine toxocariasis. | splenic responses of cba/j mice infected with 250 embryonated ova of the nematode, toxocara canis were characterized during the first month post-inoculation (p.i.). by the 6th day of infection, spleen to body weight ratios were over 3.5 times greater in infected mice than uninfected controls. this ratio peaked at 5.0 on day 14 and declined slightly by day 36 p.i. lymphocyte transformation studies were carried out using the t cell mitogens, con a and pha and the b mitogen, lps. the responses of i ... | 1984 | 6334150 |
| [visceral larva migrans due to toxocara canis. study of the clinical and laboratory characteristics of 7 human cases]. | 1984 | 6335760 | |
| meandering ocular toxocariasis. | ocular toxocariasis affects the eye in three recognizable patterns: a peripheral inflammatory mass in a quiet eye, posterior pole granuloma, or painless endophthalmitis. the present case photographically documents a new form of ocular involvement, that of periodic intraretinal meandering, followed by quiescence with encapsulation, reemergence, and renewed migration. the similar behavior of the toxocara canis larva in the animal model and the serologic confirmation of toxocara canis by elisa test ... | 1984 | 6463400 |
| [distribution of toxocara canis in puppies in bulgaria]. | 1984 | 6465617 | |
| effect of thiabendazole on the migration of toxocara canis larvae in the mouse. | the effects of thiabendazole on the survival and migration of toxocara canis larvae in mice were studied. although thiabendazole had a negligible larvicidal effect, it produced marked inhibition of the migration of the larvae in tissues. larvae were arrested in the liver after oral inoculation and in the lungs after intravenous inoculation. observations indicated that the drug may have a reversible, as well as a progressive, time-related metabolic effect on the larvae. significant inhibition of ... | 1984 | 6470886 |
| [retinoblastoma--clinical diagnostic errors]. | the author discusses clinical and histological findings in 6 patients whose complaints had been wrongly diagnosed, out of 91 patients in whom a retinoblastoma had been diagnosed at the ophthalmo-pathological laboratory of the university eye hospital in utrecht between 1960 and 1981. in 6 other cases the diagnosis was doubtful. all the cases occurred before 1974. the faulty diagnoses were: spontaneously necrotized retinoblastoma, congenital anomaly, retinal detachment, infection with toxocara can ... | 1984 | 6482302 |
| immunoradiometric assay for quantitation of dirofilaria immitis antigen in dogs with heartworm infections. | an immunoradiometric assay (irma) was developed, optimized, and validated for detection of parasite-specific antigen in sera from hosts with filarial infections, using dirofilaria immitis in dogs as a model. the precision, reproducibility, and parallelism of the irma were examined, using precision profile analysis. the irma had acceptable precision and reproducibility [less than 15% intra-assay coefficient of variation (cv)] over a working range of 10 to 2,000 ng of d immitis-antigen (ag)/ml. th ... | 1984 | 6497105 |
| a five-year analysis of diseases of dogs and cats in the veterinary clinic of freetown, sierra leone. | a survey is presented of the diagnoses found in 2938 dogs and 32 cats, treated between january 1976 and january 1980 at the veterinary clinic of freetown. more than one third of the dogs (1175) and 13 cats were infected by ancylostoma spp., whereas toxocara canis and toxascaris leonina were encountered in 236 and 232 dogs, respectively. noteworthy is also the relatively high figure of 12 dogs affected by negri bodies (rabies). it is pointed out that dogs and cats move about fairly freely in the ... | 1984 | 6508729 |
| [visceral larva migrans in childhood: report of 2 cases]. | reports of visceral larva migrans (vlm) are not frequent in brazil, but the prevalence of this disease may be more common due to poor environmental conditions to which most of the children are exposed. the most common infectious agent is toxocara canis, a parasite of the intestinal tract of dogs. children get infected eating contaminated material with feces of dogs. the ova are swallowed and reach the intestinal lumen of the children. systemic migration occurs by lymphatic or portal circulation ... | 1984 | 6517736 |
| repeated patent infection of adult dogs with toxocara canis. | three adult male greyhounds have been repeatedly infected with toxocara canis by oral administration of 100 to 200 infective ova. each infection has become patent as shown by the presence of eggs in faeces. anthelmintic treatment between 7 and 14 weeks after infection yielded an average of 25% of the inoculum as adult worms. these dogs have continued to be fully susceptible to infection despite repeated exposure to this parasite, and despite the presence of serum antibody to both parasite surfac ... | 1984 | 6520377 |
| haematological and serological data from dogs raised worm-free and monospecifically infected with helminths. | pups free from helminth infection were obtained by treating the bitch prior to parturition, and the bitch and her pups after whelping, with oxfendazole and praziquantel. they were then housed in an area free from contamination with helminth eggs. freedom from infection was confirmed by necropsy examinations and by serological tests using the enzyme linked immunosorbent assay (elisa). groups of pups were infected with toxocara canis, echinococcus granulosus, taenia ovis, t. pisiformis and t. hyda ... | 1984 | 6525114 |
| prevalence of toxocariasis and echinococcosis among dogs in the niger delta. | a sample of 60 dogs in the port harcourt area of the niger delta was examined for intestinal parasites. the high prevalence rates of toxocara canis (56.6%) and echinococcus granulosus (85.0%) in the area are discussed in relation to public health. other parasites found in dogs include toxascaris leonina (3.3%), uncinaria stenocephala (70.0%), dipylidium caninum (88.3%), trichuris vulpis (56.7%), ancylostoma caninum (65.0%) and taenia hydatigenia (43.3%). | 1984 | 6530709 |
| visceral larva migrans: a risk assessment in baton rouge, louisiana. | visceral larva migrans, vlm, is a disease of young children. due to lack of awareness of the disease as well as its non-specific symptomology, a survey of the potential risk of acquiring the disease was conducted in the baton rouge, louisiana area. the greatest number of dogs showing positive results to tests for the presence of the eggs of toxocara canis were those less than one year of age. very few of the soil samples collected from twenty different parks/playgrounds were found to contain egg ... | 1984 | 6534905 |
| experimental toxocariasis in mice and its effect on their behaviour. | when compared to uninfected controls, mice infected with second-stage larvae of toxocara canis exhibited: (1) impaired motor performance, (2) increased ambulatory activity, (3) a greater relative preference for more exposed areas and (4) a greater overall preference for novel environments. the infected mice also appeared to show less approach-avoidance conflict and seemed less cautious when presented with novel stimuli. these behavioural differences were independent of measures of general health ... | 1984 | 6540073 |
| [mouse strain difference in visceral larva migrans of toxocara canis]. | the mode of larval migration (visceral larva migrans) in toxocara canis infection was compared for balb/c, c57bl/6, c3h/he, dba/2, nc and balb/c nude mice following oral infection with 400 eggs. the mean recovery of larvae from the liver on day 2 post infection (pi) was not different in terms of the strain, age or sex of the mice. the number of larvae recovered from the liver decreased in all strains on days 6, 12 and 21 pi, but the mean for balb/c and (nc x balb/c) f1 mice was significantly hig ... | 1984 | 6542020 |
| prevalence and survival of toxocara canis eggs in the urban environment of perth, australia. | using a technique of proven efficiency no toxocara canis eggs were recovered from a total of 266 sand samples collected from "dog beaches" and parks in the perth urban area. this observation emphasises that the major risk to humans is from an environment in which puppies are found. other observations, made at a heavily contaminated site, showed that the eggs of t. canis disappeared from sandy soil over about 6 months during a period in which it would have been expected that conditions were favou ... | 1984 | 6542727 |
| the migration of larval toxocara canis in mice. i. migration through the intestine in primary infections. | toxocara canis second stage larvae (l2) hatched in the stomach of mice and within 2 h reached all parts of the small intestine, the posterior half being the preferred site for larval penetration. following penetration at the base of crypts of leiberkuhn they followed tortuous routes in the lamina propria, and entered the tunica muscularis obliquely. larvae only appeared to be arrested in their migration in the submucosa and lamina propria by an inflammatory reaction composed mainly of lymphocyte ... | 1984 | 6543062 |
| the migration of larval toxocara canis in mice. ii. post-intestinal migration in primary infections. | following oral infection of nih mice with toxocara canis embryonated eggs the l2 pass the visceral phase of migration during te first week of infection. larvae reach the liver and lungs and peak in number in these organs 2 and 3 days after infection, respectively. larvae are then dispersed throughout the body and enter the myotropic--neurotropic phase by the 7th day of infection. larvae injected directly into the brain are capable of migrating into the viscera and musculature. considerable patho ... | 1984 | 6543063 |
| antibody responses to toxocara canis using sera from parasite-infected mice and protection from toxocariasis by immunisation with es antigens. | evidence for serological cross-reactions between toxocara canis and related nematode parasites has been sought using sera from infected mice and the immunodiagnostic excretory/secretory (es) antigen of t. canis larvae. sera from mice experimentally infected with either t. canis, t. cati, t. pteropodis, toxascaris leonina or ascaris suum were tested for the presence of antibodies to t. canis es antigen by solid-phase radioimmunoassay (ria) or enzyme-linked immunosorbent assay (elisa) using anti-m ... | 1984 | 6543490 |
| anthelmintic effect of levamisole, ivermectin, albendazole and fenbendazole on larval toxocara canis infection in mice. | the anthelmintic effects of levamisole (100-50 mg kg-1 live bodyweight), ivermectin (2 mg kg-1 bodyweight), albendazole and fenbendazole (both 100 mg kg-1 bodyweight), were tested against second stage toxocara canis larvae in mice. anthelmintic treatment on days 2 to 7 after infection inclusive resulted in significant (p less than 0.05) retention of larvae in the liver, and fewer larvae migrated subsequently to the brain and the musculature of treated mice compared to untreated controls. most of ... | 1984 | 6546805 |
| a collaborative study on larval excretory/secretory antigens of toxocara canis for the immunodiagnosis of human toxocariasis with elisa. | two batches of excretory/secretory (e/s) antigens from second stage larvae of toxocara canis maintained in vitro were prepared independently in two different laboratories (zürich and basel) and analysed in order to obtain information for future efforts to standardize the enzyme-linked immunosorbent assay (elisa) used for the serodiagnosis of human toxocariasis. sds-page and "western-blotting" revealed at least 10 different antigenic components common to the two antigen preparations. however, dis ... | 1984 | 6084948 |
| effects of benzimidazole anthelmintics on the survival and migratory behavior of toxocara canis larvae in the mouse. | nine benzimidazole anthelmintics-thiabendazole, mebendazole, fenbendazole, cambendazole, flubendazole, albendazole, parbendazole, oxibendazole, and oxfendazole--were tested for their larvicidal effects and capabilities to inhibit migration of larval toxocara canis in mice. the drugs were administered in medicated diets containing 0.1% (w/w) of the pure compounds (130 to 160 mg/kg each day), starting 24 hours after oral inoculation with 500 infective eggs. groups of mice were continued on medicat ... | 1984 | 24049912 |
| [migration and distribution of toxocara canis werner 1782 (anisakidae) larvae in the definitive host (beagle) following primary infection and reinfection]. | 1985 | 3976310 | |
| induction of non-ige anaphylactic antibodies in dogs. | dogs immunized with o-dncp-bsa or eggs of toxocara canis developed anaphylactic antibodies other than ige. the antibodies were heat-resistant at 56 degrees c for 2 hours, not reduced by 2-mercaptoethanol and pca and p-k reactivity was only observed at 3-4 h sensitized sites of recipient skin. high titres of antigen-specific iggd were determined by means of an elisa technique. | 1985 | 3978874 |
| prenatal and lactational transmission of toxocara canis and ancylostoma caninum: experimental infection of the bitch before pregnancy. | 1985 | 3980144 | |
| toxocara canis in humans. | 1985 | 3980978 | |
| in vitro translation of mrna from toxocara canis larvae. | 300 micrograms of total rna was extracted from 1 ml of packed toxocara canis larvae by centrifugation through a 5.7 m cesium chloride cushion. 60 micrograms of polyadenylated messenger rna was separated from 300 micrograms of total rna in an oligothymidylic acid-cellulose gel column. the in vitro translation of the mrna, isolated from t. canis larvae, was carried out using the rabbit reticulocyte cell-free translation system. incorporation of [35s]methionine into trichloroacetic acid precipitabl ... | 1985 | 3990707 |
| immune responses of cba/j mice to graded infections with toxocara canis. | the immunological responsiveness of cba/j mice infected with various numbers of the canine ascarid, toxocara canis, was characterized after a single infection to ascertain the smallest infection capable of perturbing the immune system of the host. mice receiving the lowest inoculations (5 eggs per mouse or 0.25 larvae per g of body weight) had detectable alterations in the number of circulating peripheral blood eosinophils and spleen weight-to-body weight ratios. mice infected with 25 eggs each ... | 1985 | 3997242 |
| induction of a marked eosinophilia by cyclophosphamide in toxocara canis infected sjl mice. | cyclophosphamide (cy) is known to produce a marked eosinophilia in mice after antigen challenge. in this study, we studied the effect of cy on eosinophilia in helminthic infection. peripheral blood eosinophils were counted in sjl mice following a large dose of cy injection, infection with toxocara canis, and both cy injection and t. canis infection simultaneously. following the injection with cy (150 mg/kg), the eosinophil counts fell sharply, then rose abruptly to six times the normal level fol ... | 1985 | 4011300 |
| do toxocara canis larval antigens used in enzyme-linked immunosorbent assay for visceral larva migrans cross-react with ab isohemagglutinins and give false positive results? | a variety of helminth parasites have a and b blood group antigens on their surface. these antigens may cross-react with elevated concentrations of a and b isohemagglutinins in some patients and give false-positive results in the serologic diagnosis of visceral larva migrans caused by t. canis. to clarify this point, serum from patients with visceral larva migrans and elevated t. canis antibody titers as determined by elisa were absorbed with ab blood cells and retested by elisa without a demonst ... | 1985 | 4013469 |
| anthelmintic efficacy of febantel combined with praziquantel in dogs. | ninety-four dogs were randomly assigned to 1 of 6 groups (5 treated and 1 untreated control) for evaluation of anthelmintic efficacy. three anthelmintic formulations were studied: a febantel paste, a praziquantel paste, and a combination paste containing both active ingredients. treated dogs were dosed once daily for 3 days. the minimal effective dosages in combination were established as 10 mg of febantel and 1 mg of praziquantel/kg of body weight. at those dosages for the combination, 99.5% to ... | 1985 | 4030460 |
| biosynthetic labelling of the excretory and secretory antigens of toxocara canis larvae. | toxocara canis larvae were cultured in vitro in medium containing [35s-]methionine for six days. the medium and the larval tissues were analysed for biosynthetically labelled polypeptides by sodium dodecyl sulphate polyacrylamide gel electrophoresis and autoradiography. immunoprecipitates with positive and negative human antiserum were similarly analysed, using staphylococcus aureus to absorb immunocomplexes. the larvae secrete biosynthetically labelled polypeptides into the medium, with three m ... | 1985 | 4031454 |
| regulation of toxocariasis in mice selectively reared for high and low immune responses to nematospiroides dubius. | test mice have been selectively reared for high (h) or low (l) immune responses to nematospiroides dubius. after secondary infection with n. dubius, the l mice voided ten times as many eggs in their faeces as the h mice, and at necropsy, 71% versus 20% of the inoculum of n. dubius were recovered as adult worms from the l and h mice respectively. furthermore, n. dubius were more fecund in the l than in h mice. high or low immune responsiveness was not restricted to n. dubius infection in these mi ... | 1985 | 4031456 |
| toxocara canis larvae in the brain of a british child. | the clinical and autopsy findings of a two and a half year-old infant with toxocara sp. infection of the brain and granulomatous lesions in the liver are reported. the cause of death was non-accidental injury. the relationship between toxocara infection and behavioural disorders is discussed. | 1985 | 4035735 |
| the radioallergosorbent test (rast) for the serological diagnosis of human anisakiasis. | the serum of patients with parasitologically confirmed and one patient with a clinically presumptive case of anisakiasis were tested by the radioallergosorbent test (rast) and counter-electrophoresis (cep) for ige and igg antibodies, respectively, using antigens prepared from larval (l3) stage anisakis simplex and larval (l2) stage toxocara canis. all sera were rast-positive to the a. simplex antigen and rast-negative to the t. canis antigen. all sera were cep-negative to both antigens. the pres ... | 1985 | 4039859 |
| seroprevalence of zoonotic toxocariasis in the united states: 1971-1973. | demographic characteristics associated with human toxocara canis infection in children aged one to 11 years were investigated using data from the health and nutrition examination survey of 1971 to 1973. an enzyme-linked immunosorbent assay with larval stage antigen was used to measure the concentration of antibodies to t. canis in 1,409 available sera. from 4.6 to 7.3% of the children in different geographic regions of the united states have been infected, with serologic prevalence approaching 3 ... | 1985 | 4050776 |
| the progression of behavioral and pathological effects of the parasite toxocara canis in the mouse. | toxocara canis, the parasitic roundworm of the dog may infect aberrant hosts including mice and humans. the present study examined the behavioral and pathological changes at each of three postintubation periods (period 1: 8-10 days, 2: 49-51 days, and 3: 84-86 days postintubation, respectively) in independent groups of mice intubated with 1000 eggs of t. canis. eight-ten days after intubation toxocara infected animals typically showed depressed levels of activity relative to saline-intubated con ... | 1985 | 4059398 |
| ocular toxocariasis studied by ct scanning. | ocular toxocara canis infection causing larval granulomatosis and leading to chronic endophthalmitis and retinal detachment is a well-defined cause of unilateral leukokoria in children. the computed tomographic (ct) scan revealed a diffuse, nonenhancing, well-defined hyperdense lesion occupying most of the globe. the ct findings do not definitively differentiate the diffuse endophthalmitis of larval granulomatosis from retinoblastoma or other pseudogliomas. | 1985 | 4059556 |
| prenatal and lactational transmission of toxocara canis and ancylostoma caninum: experimental infection of the bitch at midpregnancy and at parturition. | 1985 | 4066142 | |
| [effect of fenbendazole on resting somatic larvae of toxocara canis werner 1782 (anisakidae) in the pregnant bitch]. | 1985 | 4072489 | |
| behavioral effects of early lead exposure and subsequent toxocariasis in mice. | mice were maintained under standard conditions, or treated with lead from birth, until they were approximately 40 d of age. at that time the lead solution was replaced with tap water and all animals were gastrointestinally intubated with either the parasite toxocara canis or normal saline. at 2-5 wk following intubation the behavioral effects of t. canis in combination with the prior history of lead ingestion were compared to those produced by administration of either t. canis or lead alone or a ... | 1985 | 4078936 |
| anthelmintic efficacy of flubendazole paste against nematodes and cestodes in dogs and cats. | small dogs and cats, naturally infected with nematodes and cestodes, were used in a critical test under laboratory conditions to determine the palatability and efficacy of flubendazole as a past formulation. subsequently, a control test in dogs was conducted under field conditions. a 4.4% past formulation was given at a dosage of 22 mg/kg of body weight once a day for 2 or 3 consecutive days. in a critical test in dogs, the efficacy against toxocara canis was 97.4% after a 2-day administration a ... | 1985 | 4083589 |
| transfer of infection-induced immune protection to toxocara canis in a mouse model. | groups of mice were vaccinated twice with soluble extracts of embryonated eggs, females or males of toxocara canis, or horse serum, and infected with 2,000 homologous embryonated eggs. recovery of larvae on the fifth day by digestion of mesenteric lymph nodes, liver, lung, brain, and carcass revealed a slight but nonsignificant protection elicited by the parasite materials. other groups were immunized by homologous infections. a single, 200-day-old infection increased importantly the number of l ... | 1985 | 4090262 |
| the effect of toxocara canis on the spontaneous running activity of mice. | 1985 | 4096567 | |
| serodiagnosis of ocular toxocariasis: a comparison of two antigens. | this study was designed to compare the sensitivity and specificity of enzyme linked immunosorbent assay (elisa) for the serodiagnosis of ocular toxocariasis using toxocara canis embryonated egg antigen (tee) and toxocara excretory-secretory or exoantigen (tex) produced in vitro. tee and tex elisa were comparably sensitive, but tex elisa was better able to discriminate between serum samples from patients with ocular toxocariasis and those from patients with retinoblastoma. in addition, preabsorpt ... | 1985 | 2578482 |
| demonstration of both immunologically unique and common antigenic determinants in dirofilaria immitis and toxocara canis using monoclonal antibodies. | using an elisa system, the immunological cross-reactivity between d. immitis and t. canis has been, for the first time, examined on an individual clone-by-clone basis. this study offers a definitive demonstration of the presence of immunologically distinguishable species-specific non-crossreactive antigens and the presence of cross-reactive antigens in antigenic extracts obtained from adult d. immitis and t. canis. | 1985 | 2417400 |
| isolation of specific antigens from angiostrongylus cantonensis. 1. preparative flatbed isoelectric focusing. | electrophoresis on sds gel and analytical isoelectric focusing showed that a crude extract of angiostrongylus cantonensis consisted of at least 40 protein components with molecular weights ranging from 13 000-70 000 and isoelectric points of pi values ranging from 3.7-10.0. crossed-immunoelectrophoresis with a hyperimmune antiserum to a. cantonensis showed at least 40 different antigenic components in the crude worm extract which were cross-reactive with those of ascaris suum, metastrongylus apr ... | 1985 | 2417425 |
| intestinal helminths of domestic dogs in the hessian neckar valley, federal republic of germany. | in a small town and its adjacent villages of the hessian neckar valley, federal republic of germany, 155 of the officially registered domestic dogs were examined for intestinal helminths. twenty percent of the animals proved to be infected. the highest prevalence of 5.8% could be attributed to infections with toxocara canis. these values are well below the average rates for dogs in the larger german cities. | 1985 | 3833828 |
| canine and human gastrointestinal helminthiasis of the kainji lake area, nigeria. | an investigation into gastrointestinal helminthiasis in human and dog population of the kainji lake area revealed a high prevalence of helminthiasis which may be due to lack of adequate health and veterinary facilities; crowdiness and squalid environment. the prevalent parasites in humans were ancylostoma sp, 40.33%; ascaris lumbricoides, 44.07% and strongyloides stercoralis 4.05%, while in dogs ancylostoma sp, 36.95%, dipylidium caninum, 28.26%, echinococcus granulosus, 8.69% and s. stercoralis ... | 1985 | 3833832 |
| [what is your diagnosis? geophagia complicated by toxocara canis infection]. | 1985 | 3835540 | |
| [inflammatory pseudoglioma caused by toxocara canis (anatomo-clinical study of a case)]. | 1985 | 3841849 | |
| toxocaral infection in hydatid control officers: diagnosis by enzyme immunoassay. | an enzyme-linked immunosorbent assay for toxocara canis larva excretory/secretory antigen has been set up in christchurch. employing this test, elevated specific antibody levels for toxocara larvae were found in 3.3% (3/90) of urban adult blood donors and 4.4% (4/90) of secondary school students. in comparison, elevated levels were present in 25.6% (23/90) of new zealand hydatid control officers. it can be concluded from the present study that the higher risk of toxocariasis experienced by hydat ... | 1985 | 3863049 |
| studies on the prevalence of gastro-intestinal helminths of dogs in calabar, nigeria. | the results of investigational study to determine the prevalence of gastro-intestinal helminths of dogs in calabar, nigeria with particular emphasis on the effects of sex and age of the animals on the occurrence of these endoparasites are presented. of a total of 254 dogs sampled using saturated brime solution floatation method and formalin-ether sedimentation method, 223 (86.97%) were infected. a breakdown of the number of parasitized dogs shows that 180 (70.86%) were positive for ancylostoma c ... | 1985 | 3869127 |
| comparative studies on the infestation of three different breeds of dogs by gastro-intestinal helminths. | the findings of an investigation mounted to evaluate and compare the prevalence of parasitic gastro-intestinal helminth ova in three different breeds of dogs in calabar, nigeria are presented. results of the investigation indicate that in alsatians, 25% infestation with strongyloides stercoralis, 25% toxocara canis, 65% ancylostoma caninum were found, in crossbreed between alsatian and mongrel, 15.56% infestation with strongyloides stercoralis, 10.93% toxascaris leonina, 25% toxocara canis, 68.7 ... | 1985 | 3869810 |
| [parasites present in foxes (vulpes vulpes) of the province of forli]. | in the period march 1983 - march 1984 a parasitological survey was carried out on 103 foxes killed in the forli province (italy). the parasites identified were: toxocara canis (45.6%); uncinaria stenocephala (14.6%); mesocestoides lineatus (9.7%); dipylidium caninum (2.9%); taenia crassiceps (2.9%); trichuris vulpis (2.9%). out of all the cestodes found in 7 animals the authors identified only genus taenia since their preservation conditions were not optimal. other 13 subjects contained many ces ... | 1985 | 3870647 |
| [visceral larva migrans caused by toxocara canis]. | 1985 | 3878545 | |
| specific antibody responses in dogs experimentally infected with echinococcus granulosus. | six dogs reared helminth-free were divided into 2 groups. four dogs were infected per os with 200,000 protoscoleces each of echinococcus granulosus and 2 were kept as uninfected controls. all the dogs were kept together until 32 days after infection, when 1 infected dog was killed, its intestine removed and the contents examined to confirm that the infection with e. granulosus had been successful. the remaining 3 infected dogs were transferred to high security housing and their feces inspected d ... | 1986 | 3953947 |
| toxocara canis infection and hyperactivity. | an observational study using video recordings and computer assisted data analysis showed that infection with toxocara canis larvae had a marked effect on five readily and reliably differentiable categories of murine behaviour. the infection was also associated with an increase in the number of shorter bouts of each behavior. these results indicate that infection with t. canis renders mice hyperactive, and would appear to justify a complete reappraisal of the role of this neurotropic parasite as ... | 1986 | 3632100 |
| toxocara canis: interaction of human blood eosinophils with the infective larvae. | this study was carried out to investigate the nature of the immunological responses which took place in a child who had recently recovered from toxocariasis. she had developed a marked eosinophilia and had high titers of toxocara antibodies. experiments were performed to examine whether toxocara canis infective larvae could be killed in the presence of her serum and human eosinophils. eosinophils with human complement, or this patient's serum, adhered to the surface of the larvae within 10 min. ... | 1986 | 3709753 |
| enzyme immunoassay (elisa) for the detection of specific igg antibodies to toxocara canis es antigens. | this paper reports the development of an enzyme-immunosorbent assay for the detection in human serum of specific igg against excretory/secretory antigens of second stage toxocara canis larvae. similar tests have been already used in several countries for clinical and epidemiological purposes on human toxocariasis and currently represent the only specific means for the serological diagnosis of this parasitic disease. specificity and sensitivity have been proved and original data on the epidemiolo ... | 1986 | 3718679 |
| prevalence of soil contamination by toxocara canis eggs in qalubiya governorate. | 1986 | 3722882 | |
| chemotactic reactivity of eosinophils obtained from bone marrow and peritoneal cavity of cyclophosphamide-treated, toxocara canis-infected mice. | chemotactic reactivity of eosinophils obtained from the bone marrow (bm-eo) of cyclophosphamide-treated, toxocara canis-infected mice was compared to that of eosinophils obtained from the peritoneal cavity (pec-eo). bm-eo responded well to alanyl-tetrapeptide, a synthetic eosinophil chemotactic factor of anaphylaxis (ecf-a), whereas pec-eo did not. both bm-eo and pec-eo showed almost equally high chemotactic reactivity to parasite-derived ecf, ecf lymphokine and complement-derived ecf. chemotact ... | 1986 | 3733233 |
| nonspecific allergic granulomatosis in the lungs of mice infected with large but not small inocula of the canine ascarid, toxocara canis. | infection of cba/j mice with 250 ova of toxocara canis results in development of splenic lymphocytes hyperergic to nonspecific stimuli. these studies were performed to see if the granulomatous response to a nonspecific stimulus was exaggerated. using eosinophil counts and mbsa ear thickening it was demonstrated that concurrent infection with the parasite and immunization with methylated bovine serum albumin (mbsa) elicit no immunologic cross reactions. eosinophil counts were proportional to the ... | 1986 | 3742887 |
| neuroretinitis in presumed visceral larva migrans. | neuroretinitis is a rate manifestation of toxocariasis that can occur as a late sequelae to the active disseminated phase of the disease visceral larval migrans (vlm). this case report describes a 14-year-old boy who developed vlm and concurrent neuroretinitis. during the acute illness, the patient's serum elisa titer to toxocara canis rose to greater than 256 and a lymph node biopsy revealed necrotizing lymphadenitis with eosinophilia. the constitutional symptoms of vlm may be mild and easily o ... | 1986 | 3749627 |
| [in vitro interaction between immunocompetent cells and l2 larvae of toxocara canis: immunologic aspects]. | 1986 | 3752818 | |
| [the l2 larva of toxocara canis as an immunomodulating agent]. | 1986 | 3752819 | |
| experimental toxocariasis and hyperactivity in mice. | an observational study using videorecordings and computer-assisted data analysis was undertaken in order to investigate the behaviour of mice infected with larvae of toxocara canis. the findings indicated that the infection had a marked effect on five readily and reliably differentiable categories of murine behaviour. a marked increase in the number of shorter bouts of each of the five behaviours was also associated with the infection. these results support previous findings and further suggest ... | 1986 | 3754367 |
| toxocara canis infestation. clinical and epidemiological associations with seropositivity in kindergarten children. | we studied a cohort of 333 children in kindergarten to determine the prevalence of seropositivity to toxocara canis, and to detect and measure chronic health effects that might be attributable to past infection. we found that 23.1% of the children had serologic evidence of infection (antibody titer greater than or equal to 1:32), assayed by means of an enzyme-linked immunosorbent assay. black children were more frequently infested than white children, as were children of parents who did not grad ... | 1986 | 3763150 |
| [epidemiological aspects of toxocariasis in switzerland]. | in the regions of basel, jura and zürich (switzerland) 765 blood donors completed a questionnaire with respect to symptoms, animal contacts and occupation, and their sera were tested for antibodies to tissue helminths in elisa. 5.1%, 3.3% and 6.5% exhibited antibodies solely to the respective antigens of toxocara canis, fasciola hepatica, and echinococcus granulosus. combined seroreactions were mainly observed between f. hepatica and e. granulosus antigens. reactivity to t. canis antigen was ass ... | 1986 | 3764384 |
| the relationship between toxocara elisa absorbance values and toxocara elisa titres: a comparative study. | enzyme-linked immunosorbent assays (elisas) may be made by a variety of techniques at one or several serum dilutions which is very confusing for clinicians. this study compares the elisa results from two centres on sera from 12 patients investigated for ocular toxocariasis by two common elisa methods--the absorbance and titration techniques. with one exception, elisa results by the two methods correlated well. for reasons outlined, the absorbance elisa method is likely to remain the preferred me ... | 1986 | 3768173 |
| toxocara canis infection of children in a caribbean community. | 1986 | 3768596 | |
| purification and properties of mitochondrial malate dehydrogenase of toxocara canis muscle. | mitochondrial malate dehydrogenase was purified from muscle extracts of toxocara canis by means of sephadex g-100 gel filtration, deae-sephadex ion-exchange chromatography and 5'amp-sepharose 4b affinity chromatography. the purified enzyme showed an optimum ph for the reduction of oxaloacetate of 7.3 in tris-hcl buffer and of ph 7.5-7.8 in phosphate buffer. the m-mdh showed values of 3.2 kcal/mol and 10.5 kcal/mol for the energy of activation, calculated from the arrhenius equation. the mitochon ... | 1986 | 3769454 |
| [quantitative comparison of amino acids in adult proteins of ascaris lumbricoides, ascaris suum and toxocara canis]. | 1986 | 3770717 | |
| [larva migrans visceralis--occurrence of toxocara canis in dogs in the east german district of cottbus]. | larvae of the nematode genus toxocara are the main causative agents of the l.m.v. syndrom. 5,002 dogs from the cottbus district aged between 2 and 36 months were examined. 994 animals (19.9%) were found to be infected with toxocara canis. dogs from a rural area have a higher infection rate (25.6%) than dogs from an urban area (15.2%). the relatively high infection rate of dogs, high egg-production and the tenacity of the development stages are factors dangerous to human health. | 1986 | 3777527 |
| toxocariasis: a serological survey of blood donors in the australian capital territory together with observations on the risks of infection. | the sera from 660 healthy blood donors from canberra were tested for antibodies to toxocara canis by the elisa test. the results were compared with those from patients with suspected or confirmed visceral larva migrans or ocular toxocariasis. over 7% of canberra sera showed elevated levels of antibody reacting with t. canis antigen. sera from patients resident in australia with other helminth parasites did not cross-react with t. canis antigen in our tests. however, studies of sera collected in ... | 1986 | 3787682 |
| enzyme-linked immunosorbent assay (elisa) for the detection of antibodies to angiostrongylus cantonensis. | the enzyme-linked immunosorbent assay (elisa) was employed for the sero-diagnosis of angiostrongylus cantonensis infections in rats and man. metabolic and 'purified' antigens of adult or juvenile a. cantonensis were evaluated by elisa and compared against toxocara canis antigen for sensitivity and specificity. sera and cerebrospinal fluid (csf) from both rats and man gave higher elisa values against antigens of a. cantonensis than those obtained from negative control samples. the results showed ... | 1986 | 3798533 |
| ultrastructural studies of alterations induced by microwaves in toxocara canis eggs: prophylactic interest. | the ultrastructure of toxocara canis eggs is described before and after exposure to microwaves. the morphology of normal eggs is compared to that of eggs from other helminths. following treatment, the complete disorganization of the surface structure of the shell and the loss of much turgidity of the egg are observed. the destruction of the internal structure is most marked in the center of the egg and is associated with the disappearance of some layers of the shell. in addition, there is substa ... | 1986 | 3799007 |