Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| the immunostimulant corynibacterium parvum and hematopoietic toxicity of chemotherapy. | 1976 | 1019832 | |
| mouse strain differences in macrophage activation and anti-tumor activity induced by propionibacterium acnes (anaerobic coryneforms). | effect of propionibacterium acnes on macrophage activation and antitumor activity was examined in ddn and sl mice. (1) carbon clearance was enhanced to the same extent by p. acnes treatment in both strains. (2) number of peritoneal macrophages increased to the same extent by p. acnes treatment in both strains. (3) adhesiveness of peritoneal macrophages, as demonstrated by inhibition or migration or an increase in spreading cells, was enhanced more efficiently in ddn than in sl mice p. acnes tre ... | 1976 | 1021506 |
| stimulation of the non-specific resistance by corynebacterium parvum and bacillus calmette guérin. | the effect of pretreatment of intravenously administered killed corynebacterium parvum (cp) and living bcg was studied in various model systems. both vaccines caused an increased resistance to listeria monocytogenes, indicating macrophage activation. only cp exerted a suppressive effect on t-cell-mediated immunological phenomena (skin allograft survival; antibody production to tetanus toxoid; expulsion of adult t. spiralis worms from intestine). results of experiments with congenitally athymic ( ... | 1976 | 821172 |
| the effects of activated macrophages on tumor target cells: escape from cytostasis. | 1976 | 821620 | |
| mitogenic activity of the cell walls of mycobacteria, nocardia, corynebacteria and anaerobic coryneforms. | the mitogenic activity of the cell walls prepared from mycobacterium bovis bcg, nocardia rubra, corynebacterium diphtheriae pw8, and four species of propionibacterium, corynebacterium parvum atcc 11829, propionibacterium acnes c7, propionibacterium granulosum atcc 25564 and propionibacterium avidum atcc 25577, were investigated. these cell walls were active as mitogens on normal spleen cells, anti-o sera-treated spleen cells, macrophage-depleted spleen cells of c57bl/6j mice and cortisone-treate ... | 1976 | 824484 |
| interaction of tumor cells and activated macrophages in vitro: modulation by corynebacterium parvum and gold salt. | 1976 | 825644 | |
| antitumor antibodies and immunoglobulin class and subclass levels in corynebacterium parvum-treated mice. | changes in immunoglobulin class and subclass levels and the development of antitumor antibodies were assessed in normal and tumor-bearing mice challenged with corynebacterium parvum. c. parvum administration resulted in a marked increase in certain immunoglobulin levels, especially ig g2b, and in the development of antibodies reacting with syngeneic and allogeneic tumor cells. the serologic changes induced by c. parvum were dependent on the dose and route of administration; preliminary studies s ... | 1976 | 825650 |
| specific and nonspecific antitumor immunity. iii. specific t lymphocyte-mediated cytolysis of p815 mastocytoma and sl2 lymphoma by draining lymph node cells from syngeneic tumor-bearing dba/2j mice. | tumor-specific cytolytic activity, as measured by the 51cr release assay, has been demonstrated in the draining lymph node cells from dba/2 mice bearing the syngeneic p815 mastocytoma or sl2 lymphoma. this lytic activity is mediated by cytolytic t lymphocytes (ctl), since cytotoxicity is eliminated by treatment of the effector cells with anti-thy 1.2 (theta) serum plus complement but is enhanced or unaffected by anti-thy 1.2 serum alone, antimouse immunoglobulin plus complement, normal or aggreg ... | 1976 | 826167 |
| failure of corynebacterium parvum presensitization to modify the antitumor effects of systemic and local therapeutic injections of c. parvum in mice. | the therapeutic effects of iv and intralesional injection of corynebacterium parvum against mastocytoma p815 in mice, presentized and showing marked delayed hypersensitivity to c. parvum, were no different from those in unimmunized controls. | 1976 | 815560 |
| serum lysozyme as a marker of host resistance. i. production by macrophages resident in rat sarcomata. | with progressive growth of syngeneic sarcomata in rats there was a rise in serum levels of lysozyme which correlated with their immunogenicity and their macrophage content. by an examination of lymph/blood differences in normal and in tumour bearing rats and of the production of lysozyme by cells obtained from the tumours and maintained in vitro, it is apparent that the macrophages resident in a tumour mass make a massive contribution to the elevation in serum lysozyme concentrations. tumour cel ... | 1976 | 766806 |
| proceedings: the effect of bacille calmette-guérin (bcg) and corynebacterium parvum on the development of spontaneous mouse mammary carcinoma. | 1976 | 766891 | |
| immunology and lung cancer. | carcinoma of the lung is the number one cancer killer in the united states. the overall cure rate is about 10%, and although resection is the best treatment available, five-year survival following operation is only 25%. recent studies have shown that patients with lung cancer are immunosuppressed but that pulmonary tumors do contain tumor-associated antigens. studies of other human tumors indicate that immunotherapy can augment tumor immunity and can be an effective surgical adjuvant. this commu ... | 1976 | 769714 |
| immunogenicity of a rat leukaemia of spontaneous origin (sal). | the sal rat leukaemia, which resembles acute myeloblastic leukaemia, appeared initially to be non-immunogenic since resistance to an i.p. challenge with as few as 100 cells could not be obtained using stimulation of the res or by immunization with sal cells exposed to x-rays, nitrogen mustard, iodoacetate or glutaraldehyde. however, immunization with sal cells exposed to low doses of mitomycin-c slowed the growth of the challenge inoculum. cells treated with high doses of mitomycin-c did not imm ... | 1976 | 769814 |
| nonspecific immunotherapy by corynebacterium parvum: phase i toxicity study in 12 patients with advanced cancer. | corynebacterium parvum, a non-specific immunopotentiator, was administered intravenously to 12 patients with advanced cancer at 2, 3, and 4 mg/m2 dose levels in combination with radiation therapy. one dose of c. parvum was given every 7 days for a total of 4 doses in 21 days. symptoms and signs developed by these patients for a period of 3 to 6 hours during and shortly after the i.v. infusion of the first dose of c. parvum were moderately severe in nine patients and mild in three patients. for t ... | 1976 | 769937 |
| bacillus calmette-guérin immunotherapy in combination with dtic (nsc-45388) for the treatment of malignant melanoma. | combination studies of immunotherapy and dtic chemotherapy for patients with malignant melanoma are described. at our institute the combination of bacillus calmette-guérin (bcg) with dtic, or dtic plus methyl-ccnu, has resulted in augmentation of remissions in areas regional to bcg immunization, prolongation of chemotherapy-induced remissions, and significant prolongation of survival compared to the use of dtic chemotherapy without immunotherapy. data from other centers have shown that augmentat ... | 1976 | 769970 |
| the role of macrophages in the adjuvant effect on antibody production of corynebacterium parvum. | spleen cells from mice pre-treated with c. parvum gave an enhanced in vitro antibody response to srbc, but not to dnp-pol. this enhancing activity was associated with the adherent, but not the non-adherent spleen cell population and was found to be radioresistant. it is concluded that macrophages are directly involved in the adjuvant effect of c. parvum and the possible mechanisms of action are discussed. | 1976 | 770033 |
| "xenogeneic resistance" to rat bone marrow transplantation. iii. maturation age, and abrogation with cyclophosphamide, corynebacterium parvum and fractionated irradiation. | lethally irradiated c57 bl/6 mice and (c57 x a) f1 hybrids fail to accept doses of rat bone marrow cells (5 x 10(6)) which give confluent splenic repopulation in "non-resistant" strains of mice. this phenomenon has been termed "xenogeneic resistance" (xr). xr in (c57 x a) f1 mice can be overridden by a very large inoculum of rat bone marrow (26 x 10(6) cells). xr is not manifest in mice of a resistant strain at ages of 18 days or younger, but is manifest at ages of 22 days and older. xr can be a ... | 1976 | 773442 |
| overview of tumor immunology in gynecologic oncology. | highlights of recent advances in the field of gynecologic tumor immunology are presented in an effort to demonstrate that at least some cancers of the female genitalia evoke an immune response that can be quantitated in the laboratory. the overview will discuss investigations into the various in vitro assays of both humoral and cell-mediated immunity. the concept of clinical testing of delayed hypersensitivity reactions as it relates to the clinical outcome of the patients with malignancy is pre ... | 1976 | 776391 |
| the effect of hydrocortisone on the immune response of mice treated with corynebacterium parvum. | 1976 | 776469 | |
| enhancement of tissue invasion in murine aspergillosis by systemic administration of suspensions of killed corynebacterium parvum. | the effect of killed corynebacterium parvum vaccine on the course of murine aspergillosis is described. a grid-counting technique was employed to quantitate tissue invasion by aspergillus nidulans in the brain, heart, and kidneys (the target organs) of normal mice and of mice treated systemically with killed c. parvum vaccine. simultaneous treatment of mice with c. parvum and a. nidulans significantly increased the mortality rate, in contrast to treatment of mice with c. parvum prior to or follo ... | 1976 | 779492 |
| augmentation of specific macrophage-mediated cytotoxicity: correlations with agents which enhance antitumor resistance. | 1976 | 782731 | |
| immunotherapy of cancer in man. | 1976 | 786091 | |
| combined treatment of rodent fibrosarcoma by radiotherapy and immune adjuvant. | 1976 | 786964 | |
| the immunobiology of colorectal cancer. | 1976 | 793017 | |
| immunotherapy of cancer in man: current status and prospectus. | 1976 | 793477 | |
| design of phase-i trials of immunopotentiators for cancer therapy: levamisole and corynebacterium parvum. | 1976 | 793480 | |
| characteristics of bacteria isolated by the anaerobic roll-tube method from cheeses and ground beef. | in this study the methods of hungate were used to quantitate the anaerobic bacteria present in commercially available ground beef, cheddar cheese, and german hand cheese. of 235 anaerobic roll-tube isolates from ground beef and german hand cheese, all were facultative anaerobes. of 213 anaerobic roll-tube isolates from cheddar cheese, 91% were facultative anaerobes and 9% were obligate anaerobes. using results of biochemical tests, 14 or the 17 obligately anaerobic isolates from cheddar cheese w ... | 1976 | 793523 |
| relationship between intradermal tumor suppression and tumor immunity. | intradermal (id) injection of three tumor-immune stimulant mixtures (lstra-bcg, 13762a-bcg, cad2-corynebacterium parvum) was superior to the sc site for suppression of tumor growth: suppression of lstra-bcg mixtures was even less efficient after an ip or iv injectiouppression at all four sites. in the lstra-bcg model, the id site was not uniquely favorable for either the afferent or efferent limb of the immune response; the other sites produced equally effectiveimmunization or rejection of tumor ... | 1976 | 794505 |
| immunotherapy of gastrointestinal cancer: the potential. | 1976 | 798647 | |
| immunocompetence, immunodeficiency and prognosis in cancer. | immunocompetence and prognosis are related in solid tumors, malignant lymphomas, and acute leukemia. among the parameters of immunocompetence vigorous delayed-type hypersensitivity responses to recall antigens or to primary immunization with keyhole limpet hemocyanin, vigorous in vitro lymphocyte blastogenic responses to mitogens such as pha, and relatively high b-lymphocyte levels, all correlate with a good prognosis. the spectrum of immune reactivity as measured by established delayed-type hyp ... | 1976 | 800324 |
| biological activities of propionibacterium acnes from the human oral cavity--dermal toxicity and res-stimulating activity. | 1976 | 802175 | |
| responsiveness of senescent mice to the antitumor properties of corynebacterium parvum. | the antitumor properties of corynebacterium parvum have been studied in young (3- to 8-month-old) and aged 18 or more months old) balb/c mice given s.c., i.m., i.p., or i.v. transplants of the highly malignant, weakly immunogenic line 1 lung carcinoma, and in aged (25- to 33-month-old) balb/c mice bearing primary mammary tumors. these aged balb/c mice were shown to be less immunoresponsive than their younger counterparts, and this, in combination with nonimmunological factors, made them more sen ... | 1976 | 1247995 |
| suppression of the incidence of death with spontaneous tumours in dba/2 mice after corynebacterium parvum-mediated rejection of syngeneic tumours. | 1976 | 1250378 | |
| studies on the fc receptor bearing cells in a transplanted methylcholanthrene induced mouse fibrosarcoma. | the presence of fc receptors on the surface of cell suspensions obtained from a transplanted isogeneic methylcholanthrene induced murine fibrosarcoma has been investigated by determining the capacity of such cells to form rosettes with antibody coated srbc. these studies indicate that a large percentage of cells in the tumour had fc receptors on their surface. the proportion of such cells was increased by reducing the number of cells transplanted, by administering cyclophosphamide to the host, a ... | 1976 | 1252329 |
| proceedings: immunological mechanisms involved in the inhibition of tumour metastases by corynebacterium parvum. | 1976 | 1252731 | |
| antitumor activity of corynebacterium parvum extracts. | extracts of corynebacterium parvum produced by mild hydrolysis of the whole organisms had antitumor activity if given iv 1 day before iv administration of fibrosarcoma cells or if given ip or sc in admixture with these cells. a lipid component seemed responsible for these effects. unlike whole bacteria, they had little immunotherapeutic activity if given 3 days after sc tumor implantation unless absorbed onto latex. however, organisms treated with acid did not have any immunotherapeutic effect i ... | 1976 | 1255777 |
| further observations on the inhibition of tumor growth by corynebacterium parvum with cyclophosphamide. ii. effect of cortisone acetate. | studies from this laboratory have demonstrated that the administration of cyclophosphamide (cy) and corynebacterium parvum (cp) over a prolonged time to c3h mice with established measurable tumors resulted in complete arrest of tumor growth as well as partial and complete regressions in many instances. a study of the effect of two different doses of cortisone acetate (ca), administered two or five times weekly, on the tumor inhibitory properties of this chemoimmunotherapeutic regimen indicated t ... | 1976 | 1255788 |
| anaerobic infections in children: a prospective study. | the prevalence and significance of anaerobic infections in patients at st. louis children's hospital were studied prospectively for a one-year period. blood, selected body fluids, and aspirates obtained from abscesses or areas of cellulitis were cultured using special anaerobic collection and processing techniques. infected peritoneal fluid from patients with gastrointestinal disease yielded a large proportion of all anaerobic isolates. the types of organisms isolated were common inhabitants of ... | 1976 | 1256941 |
| immunotherapy and human tumor immunology. | present knowledge about the immune response to tumors in man is briefly reviewed, and the effects of cancer on immune-system functions are noted. the concepts that human tumors elicit cell-mediated immune responses to tumor antigens are re-examined and modified; for example, cell-mediated immunity may be detectable only at certain stages of tumor growth. introduction of more sensitive methods for detecting antibodies is providing additional evidence for humoral immune responses to tumor-associat ... | 1976 | 1259292 |
| effect of corynebacterium parvum on the response to irradiation of a c3h fibrosarcoma. | a methylcholanthrene-induced fibrosarcoma of c3h mice has been used as 5th- to 6th-generation syngeneic transplant in an investigation of the role of corynebacterium parvum as an adjuvant to the therapeutic effect of local irradiation of established tumors. the most effective route for administration of c. parvum in this tumor system was i.v., and the greatest effect of the c. parvum-mediated tumor graft rejection was observed for tumor growing intracutaneously or s.c. an intermediate level of e ... | 1976 | 1260756 |
| antitumour effect of corynebacterium parvum. possible mode of action. | 1976 | 1268035 | |
| bioassay for quantitating circulating tumor cells in a syngeneic mouse tumor system. | a bioassay is described for the quantitation of tumor cells in blood specimens in a syngeneic mouse tumor system (sarcoma 1 in a/j mice). the procedure involved i.m. injection of blood containing tumor cells into each thigh of normal recipient mice and, 14 days later, examination of the sites of injection for evidence of tumor growth. for each specimen, a tumor index was calculated based on the number of tumor takes and the size of the tumors. the number of tumor cells was determined by comparis ... | 1976 | 1268858 |
| corynebacterium parvum. | 1976 | 1269143 | |
| importance of actinomyces and certain gram-negative anaerobic organisms in the transformation of lymphocytes from patients with periodontal disease. | dental plaque deposits are known to be potent stimulants of lymphocyte transformation in patients with periodontal disease but not in normal subjects. since plaque deposits consist mainly of whole bacteria, the cell walls of the most commonly found organisms in plaque were tested for their capacity to induce lymphocyte transformation. there was a direct correlation between the severity of peridontal disease and the amount of transformation induced by the cell walls of oral bacteria and by solubi ... | 1976 | 1270144 |
| modification of the effect of c. parvum on macrophage activity and tumour growth by x-irradiation. | the radiosensitivity of three forms of response to injection of c. parvum in mice has been investigated. the increase in phagocytin index evoked by ip or iv injection of 0.7 mg c. parvum (but not that evoked by 1.4 mg) was reduced but not abolished in mice given 350-500 rad whole-body irradiation 4 days before c. parvum injection. irradiation (500-1,000 rad) 4 days after c. parvum injection had no such effect. the antitumour cytotoxicity in vitro of pe and spleen cells from c. parvum-treated mic ... | 1976 | 1270180 |
| [antibacterial and bactericidal activity of tinidazole against anaerobic bacteria comparing with metronidazole (author's transl)]. | antibacterial activity of tinidazole (1-2-(ethylsulfonyl)-2-methyl-5-nitroimidazole) against anaerobic bacteria including peptococcus, peptostreptococcus, eubacterium, propionibacterium, bacteroides and fusobacterium was studied by agar dilution method comparing with metronidazole. in addition to this work, bactericidal effect of tinidazole and metronidazole against p. prevotii, b. fragilis ss. fragilis and f. varium was examined by quantitative culture method after incubation in gam broth conta ... | 1976 | 1271586 |
| anaerobic coryneforms isolated from human bone marrow and skin. chemical, biochemical and serological studies and some of their biological activities. | eighteen isolates if anaerobic coryneforms from human bone marrow and skin and four type strains of propionibacterium were studied chemically, biochemically and antigenically. all of the isolates were identified as propionibacterium acnes; of the 18 isolates,16 belonged to sterotype i and two to serotype ii. by means of gas liquid chromatography and mass spectral analysis, a large amount of iso-type fatty acids, such as iso-pentadecanoic and iso-heptadecanoic acids were detected in whole cells o ... | 1976 | 1271588 |
| treatment of cancer with immunomodulators. | 1976 | 1271891 | |
| the effects of corynebacterium parvum and surgery on the lewis lung carcinoma and its metastases. | the effects of corynebacterium parvum on the mouse primary lewis lung carcinoma and its metastases were studied. c. parvum was given at the same time as subcutaneous inoculation of tumour or in combination with surgical excision of the primary after 10 days' growth. when intravenous c. parvum was given at the same time as tumour there was a reduction in the primary tumour growth rate. there was a similar reduction in growth if the drug was given intravenously 7 days after tumour inoculation. int ... | 1976 | 1276661 |
| the effect of corynebacterium parvum in combination with 5-fluorouracil, l-phenylalanine mustard, or methotrexate on the inhibition of tumor growth. | previous reports from this laboratory have demonstrated conclusively that cyclophosphamide administered asynchronously with corynebacterium parvum (cp) results in greater c3h mammary tumor inhibition than that observed with either agent alone. an analysis of this combination has revelaed that the chemotherapeutic component contributes more significantly to tumor inhibition than does the immunotherapeutic one. this study was conducted to investigate the inhibition of c3h mammary tumors by other c ... | 1976 | 1277181 |
| hydrosoluble immunostimulants of bacterial and synthetic origins. | the role of whole mycobacteria, mycobacterial cell walls and waxes d as immunostimulants was well established many years ago. more recently three different research groups have shown that hydrosoluble components from mycobacterial and other bacterial origins were as active as waxes d or cell walls and were free of many side-effects. studies concerning the relationship between structure and activity were achieved which led to the description of a small biologically active fragment and to a first ... | 1976 | 181265 |
| [treatment of acne vulgaris in practice]. | the aim of all acne therapy is sebostasis and treatment of corynebacterium acnes as well as secondary infected postular changes. after discussion of tretinoin (retinoic acid)-treatment it is reported about 35 cases of acne vulgaris which were treated with the combination of hexachlorophenspiritus 1%,silicatgel locally and tetracycline orally. the good results of this treatment are reported. side effects have not been observed. | 1976 | 184016 |
| c. parvum suppression of rat tumours in athymic nude mice. | 1976 | 184813 | |
| immune response against hamster erythrocytes in the low-responder mouse strains. xi. strain difference in the effects of various microbial adjuvants. | enhancing and suppressing effects of microbial adjuvants were studied in female mice of the c3h/he, akr and sl strains. propionibacterium acnes, bordetella pertussis, bcg and yeast cell wall (ycw) were chosen as adjuvants. as antigens, we chose hamster erythrocytes (hrbc) which proved to be a weak antigen for mice. adjuvants were given on day --7, day 0 or day 3, and hrbc were injected on day 0. the results were as follows. 1) p. acnes facilitated igm and igg antibody production in akr mice and ... | 1976 | 186656 |
| immunochemotherapy with corynebacterium parvum in disseminated cancer. | 1976 | 187100 | |
| clinical immunoadjuvant studies with tilorone, deaa fluorene (rmi 11,002da), and corynebacterium parvum and some observations on the role of host resistance and herpes-like lesions in tumor growth. | 1976 | 187101 | |
| modulation of mouse anti-trinitrophenyl plaque-forming cell affinity by adjuvants or lectins. | the efffects of several kinds of adjuvants or lectins, such as corynebacterium parvum, dextran, poly au, poly ic, dibutyryl camp, concanavalin a (con a), phytohemagglutinin (pha) and pokeweed mitogen (pwm) on anti-trinitrophenyl (tnp) direct plaque-forming cells (pfc) in the spleen of mice and the affinity of antibodies produced by these pfc were examined. the numbers of anti-tnp pfc in the spleens of mice which had been injected with c. parvum 7 days in advance were greater than those in contro ... | 1976 | 190432 |
| role of microorganisms in dandruff. | the role of microorganisms in dandruff was studied, by suppressing individually and then collectively the three major components of the scalp microflora. the effect on dandruff was assessed subjectively by clinical grading and objectively by the corneocyte count. no effect on dandruff was demonstrated when scalp organisms were suppressed. in the second group of experiments, dandruff was suppressed by selenium sulfide shampooling and the effect of continued suppression of pityrosporum with topica ... | 1976 | 130835 |
| [sebaceous filaments (author's transl)]. | sebaceous filaments are cylindrical tubes of whitish-yellowish color, which can be expressed from areas of the face rich in sebaceous follicles by pinching the skin or by the cyanoacrylat-technique. sebaceous filaments are most commonly found in the centrofacial areas and the alae nasae in postpuberal individuals with large facial pores and seborrhea. sebaceous filaments are composed of a skeleton of 10-30 horny cell layers which enclose a mixture of bacteria, sebaceous lipid, corneocyte fragmen ... | 1976 | 130839 |
| acne vulgaris: current concepts in pathogenesis and treatment. | 1976 | 131110 | |
| the microbiology of dandruff. | 1976 | 131574 | |
| [the pathogenesis of acne vulgaris (author's transl)]. | stickl's method of oral treatment of acne vulgaris with antigens has been carried out on 26 test persons. during the treatment the number of comedones increased significantly and the number of papules decreased significantly. biochemically, a significant increase of the free fatty acids and a significant decrease of the triglycerides could be demonstrated in the skin surface lipids, the total amount remaining unchanged. the following important conclusions for the pathogenesis of acne may be draw ... | 1976 | 131909 |
| [studies on ozone therapy of acne vulgaris]. | ozone therapy using the vapozone 9, an instrument in normal commercial usage, has been carried out on the forehead of 16 male test persons on 7 consecutive days. before the treatment began and at the end of the treatment period the skin surface lipids on the unchanged skin (casual level) and two hours after defatting the skin (replacement sum) were taken by direct extraction and analysed by means of thin layer chromatography. the results of these investigations rule out a decrease in the free fa ... | 1976 | 134522 |
| topically applied antibiotics in acne vulgaris: clinical response and suppression of corynebacterium acnes in open comedones. | topical antibiotics were used on patients with acne vulgaris. corynebacterium acnes organisms from open comedones were quantitated during treatment, and the progress of the disease was evaluated. clindamycin lotion completely suppressed the growth of c acnes organisms, whereas erythromycin and tetracycline did not depress the c acnes counts. taken as a group, these antibiotics gave a substantial improvement of the disease on the treated side as compared with paired untreated sides of the face a ... | 1976 | 134675 |
| lipases: their questionable role in acne vulgaris. | 1976 | 136423 | |
| [ultrastructure and microflora in follicles and comedones]. | the resident flora of skin surface, sebaceous follicles, and acne comedones: pityrosporum, micrococci, and corynebacterium (propionibacterium) acnes is described. the nomenclature, topography, incidence, pathogenic role, and especially the ultrastructural morphology of these organisms are presented. | 1976 | 136430 |
| propionibacterium acnes: pathogen in central nervous system shunt infection. report of three cases including immune complex glomerulonephritis. | propionibacterium acnes is a pleomorphic gram-positive anaerobic rod usually isolated as a contaminant from skin. we report three cases of p. acnes infection of central nervous system shunts for hydrocephalus. the organism was seen repeatedly on gram stain in a specimen of shunt fluid in all three cases; initially, it was regarded as a contaminant. in addition, two of the patients had precipitins to extracts of their organism. serum from normal control subjects had no such precipitins. one of th ... | 1976 | 137672 |
| [acne vulgaris: review of the pathogenecity and the therapeutic problem from bacteriological view point (author's transl)]. | 1976 | 138000 | |
| a microbial etiology of acne? | the view is advanced that sebum as originally produced must contain materials, other than lipids, which may serve as a selective substrate for growth of bacteria and yeasts. growth of large numbers of p. acnes and p. granulosum in some follicles is considered to place those follicles at risk of undergoing pathological changes. deleterious products of bacterial growth could be not only lipase and free fatty acids, but also other enzymes as well as bacterial antigens and unspecified toxins or irri ... | 1976 | 138542 |
| acne from an immunological perspective. | patients with acne vulgaris, particularly those with severe inflammatory forms of the disease, are known to have high titers of serum antibodies, and intensified immediate hypersensitivity reactions to p. acnes antigens. the significance of this fact has not been clarified, but it is possible that antigen-antibody reactions involving p. acnes in the perifollicular dermis could intensify the inflammatory response in certain forms of acne. further studies utilizing newer, more sophisticated techni ... | 1976 | 138543 |
| antibiotic resistant acne. | our approach to a patient who fails to respond to antibiotics is as follows: first, take a careful history. look for use of cosmetics and topical corticosteroids, anticonvulsive agents and systemic corticosteroids. inquire about marked increases in emotional or psychological stresses accompanied by noticeable seborrhea. probe the patient about habits of leaning on or squeezing acne areas, and most importantly, inquire how often and in what manner the patient washes. in the physical examination, ... | 1976 | 138553 |
| symptoms from corynebacterium parvum. | 1976 | 61475 | |
| [recent personal results in advanced bronchial cancer. palliative immuno-chemotherapy. 63 cases]. | 1976 | 64125 | |
| antimicrobial effects of some bis-biguanides on certain bacteria which occur in connection with acne vulgaris. | 1976 | 6710 | |
| corynebacterium parvum toxicity. | 1976 | 73819 | |
| biological purpose of acne. | it is argued that the close endocrine control of human sebaceous glands and the likely effects of acne on selection indicate that both gland and disease have persisted because they are biologically useful. two possibilities are proposed: sebum may provide precursor substrates for metabolism and synthesis by the epidermis of compounds of both local and systemic importance; and the adjuvent properties of corynebacteria which colonise the active sebaceous glands of acne may facilitate certain gener ... | 1976 | 58315 |
| study of elastolytic activity propionibacterium acnes and staphylococcus epidermis in acne vulgaris and in normal skin. | histopathological sections of anetoderma-like scars from 10 patients with acne vulgaris showed a selective absence of elastic fibers around pilosebaceous follicles. this finding is similar to the histologic changes of "perifollicular elastolysis" reported by varadi. bacteria isolated by anaerobic and aerobic cultures of swabs of the skin surface and pus of these 10 patients, 12 others with active acne vulgaris and 8 normal subjects were studied with particular attention to staphylococcus epiderm ... | 1976 | 60023 |
| metronidazole and acne. | the strong activity of metroindazole against obligate anaerobes suggested that the organism proprionobacterium acnes and the disease acne vulgaris might respond to treatment with this drug. thirty-three clinical isolated of p. acnes were tested and found to be highly resistant to metronidazole. prospects for its successful use in acne are remote. | 1976 | 60028 |
| editorial: immunostimulation. | 1976 | 60577 | |
| bacteriocin-like activities of human dental plaque flora against oral anaerobic microorganisms. | 1977 | 26477 | |
| the bacteriology of skin cysts. | thirty-nine clinically uninflamed cysts of the three most common varieties, epidermoid cysts, trichilemmal cysts and steatocystoma multiplex were removed under sterile conditions and the contents cultured under aerobic and anaerobic conditions. seventy-three percent of epidermoid cysts grew significant numbers of organisms whereas none of the trichilemmal cysts did so. the organisms found were the common skin commensals, staphylococcus epidermidis biotype i, anaerobic gram positive cocci of the ... | 1977 | 17428 |
| mechanism of inhibition of immunization with irradiated tumour cells by a large dose of corynebacterium parvum. | 1977 | 18742 | |
| immunotherapy of human cancer. | 1977 | 65906 | |
| studies on the regulation of lymphocyte reactivity by normal and activated macrophages. | 1977 | 67900 | |
| immunochemotherapy in 34 cases of oat cell carcinoma of the lung with 19 complete responses. | thirty-four previously untreated patients with oat cell carcinoma of the lung were treated with a myelotoxic combination of cyclophosphamide, adriamycin, methotrexate, ccnu, and corynebacterium parvum (regimen a) every 4 weeks, interspersed with a non-myelotoxic combination including bleomycin, vincristine, dehydroemetine, and corynebacterium parvum (regimen b) weekly the other 3 weeks or when hematologic toxicity prohibited administration of regimen a. hematologic toxicity was frequent but was ... | 1977 | 68827 |
| [progress in medicine in individual presentations, xi. modern forms of therapy in acne]. | several pathogenetic factors contribute to the development of acne vulgaris. these include genetic predisposition, hormonal influences, increasing sebaceous secretion, bacterial colonization of the follicle and keratinization defects in the follicular epithelium. modern acne therapy can take specific forms on the basis of recent research on pathogenesis. sebostatic therapy can be performed by the topical application of benzoyl peroxide or the systemic administration of hormones (oestrogens, anti ... | 1977 | 73259 |
| predominant cultivable microbiota in periodontosis. | 1977 | 138729 | |
| acne fulminans: investigation of acute febrile ulcerative acne. | eight cases of acne fulminans (acute febrile ulcerative acne) are compared with 13 previously reported cases. this rare disorder of male teenage patients is characterized by the sudden appearance of highly inflammatory, tender, ulcerative and crusted lesions on the back, chest, and face: it is one of the most scarring acute dermatologic disorders of young patients. at the onset of the disease, all patients showed febrile temperatures and marked leukocytosis; other systemic symptoms occurred with ... | 1977 | 139850 |
| an acne-free naevus. | investigation of rare disorders may sometimes help in the understanding of common problems. we describe a patient with an unusual and previously unreported acne-free naevus occurring in an area severely affected by acne. investigation revealed smaller sebaceous glands, a reduced sebum excretion rate, decreased number of corynebacterium acnes in the pilosebaceous ducts and a reduced conversion of testosterone to 5 alphadihydrotestosterone in the areas which were free of acne compared with acne-be ... | 1977 | 139913 |
| the inability of a bacterial lipase inhibitor to control acne vulgaris. | 1977 | 142119 | |
| [therapy of acne vulgaris using panoxyl]. | 1977 | 143138 | |
| an in vivo evaluation of the inflammatory effect of purified comedonal components in human skin. | 1977 | 143497 | |
| lymphocyte transformation in subjects with nodulo cystic acne. | patients with severe nodulo-cystic acne are known to have elevated serum antibody levels and increased immediate hypersensitivity reactions to propionibacterium acnes. this organism is the predominant bacterium in normal pilosebaceous follicles of human skin, and can be consistently isolated from pustular lesions in acne. previously it had been observed that delayed cutaneous hypersensitivity reactions to p. acnes were negative in patients with acne. the present study investigated the proliferat ... | 1977 | 143951 |
| acne vulgaris: recent advances in pathogenesis and treatment. | hormonal factors, particularly androgens, appear to be important in the pathogenesis of acne vulgaris. the sebaceous glands in acne are more sensitive to normal blood levels of androgens, and are stimulated to produce more sebum. corynebacterium acnes in the sebaceous follicles act on triglycerides in the sebum to form free fatty acids which might alter the process of keratinization in the follicular canal. a microcomedo is formed which can progress to the clinical lesions of acne. sebum and its ... | 1977 | 144774 |
| [strains of propionibacterium acnes isolated from acne vulgaris (author's transl)]. | 1977 | 146146 | |
| a reevaluation of fatty acids as inflammatory agents in acne. | the currently widely held theory that intrafollicular free fatty acids (fa) are the primary agents instigating inflammatory changes in acne is based on circumstantial evidence. there is no direct evidence that fa in physiologic concentrations are inflammatory. in the present study the quantities of fa present in isolated pilosebaceous ducts and in isolated comedones were analyzed. using these values, the effect of fa on intracutaneous injection into human skin was investigated. the range of fa i ... | 1977 | 137937 |
| immunomodulation of host resistance to experimental viral infections in mice: effects of corynebacterium acnes, corynebacterium parvum, and bacille calmette-guérin. | resistance to a representative group of experimental virual infections in mice was significantly enhanced by nonspecific modulation of host defense mechanisms. corynebacterium acnes, corynebacterium parvum, and bacille calmette-guérin were effective in enhancing host resistance. animals treated seven to 10 days before inoculation of virus were protected against a lethal infection with herpesvirus hominis type 2, encephalomyocarditis virus, murine cytomegalovirus, or semliki forest virus. the pro ... | 1977 | 192811 |
| immunomodulator-induced resistance against herpes simplex virus. | 1977 | 193122 | |
| immunological mechanisms in metastatic spread and the antimetastatic effects of c. parvum. | the effects of the host's immune response on metastatic spread was investigated by observing the numbers of pulmonary metastases that developed from an s.c. implant of the lewis lung carcinoma in c57bl mice in which different cell populations had been suppressed. macrophage function was impaired by treatment with silica (si), cortisone acetate (ca), or trypan blue (tb). t-cell function was depressed by adult thymectomy and sublethal irradiation, or by treatment with antilymphocyte serum (als). m ... | 1977 | 193547 |
| protection against herpes simplex virus infection in mice by corynebacterium parvum. | corynebacterium parvum administered in mice prior to herpes simplex virus (hsv) infection significantly protected them against lethal encephalitis. this was seen both with a mouse strain highly susceptible to hsv and with one relatively resistant to hsv. mice immunosuppressed by cyclophosphamide and showing an increased mortality after hsv infection were also protected by c. parvum pretreatment. however, c. parvum given simultaneously with or after hsv infection did not exert a therapeutic effec ... | 1977 | 194841 |