Publications

lesions of the myofibril in myopathic and normal tissue from seven striated muscles. experimental myopathy of isometric activity produced by phencyclidine and restraint.		1979	419941
stability of estrogen receptors in frozen human breast tumor tissue.	the effect of freezing on the stability of the estrogen receptors in human breast tumors was measured. portions of three tumors kept frozen for 3 days after removal from the patients were analyzed by the sucrose density gradient method. the initial measurements demonstrated positive receptor values. the remaining portions were kept frozen for 30 days, and the receptor values were reevaluated. the 8s receptor was 80% destroyed under these freezing conditions. the 4s receptor was found to be more ...	1979	427754
contribution of adrenal medulla, spleen and lymph, to the plasma levels of dopamine beta-hydroxylase and catecholamines induced by hemorrhagic hypotension in dogs.		1979	438992
the effect of some anti-rheumatic agents on tuberculin pleurisy in the guinea-pig [proceedings].		1979	497564
2,3,7,8-tetrachlorodibenzo-p-dioxin: covalent binding of reactive metabolic intermediates principally to protein in vitro.	2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) is metabolized by the mouse liver cytochrome p-450-mediated monooxygenase system to reactive intermediates which bind 'covalently' to cellular macromolecules. although very difficult to quantitate, the presumably covalent binding to microsomal protein occurs between 120 and 2,640 times more readily than binding to deproteinized dna in the in vitro reaction. because of the extremely high rate of binding to protein rather than to dna, it is visualized tha ...	1979	515166
[response of certain laboratory animals to being fed an ocean fish, the ruvette].		1979	516605
[dry adapting additive and its use in dairy products for approximating the composition of human milk].	the paper concerns a procedure for a new product, dry adapting additive (daa), designed for manufacture of liquid substitutes of breast milk under industrial conditions. the chemical composition of adapted milk mixtures is compared to that of breast milk. procedures for adapted mixtures to be manufactured at city milk kitchens, food concentrate factories and under domestic conditions have been developed, with the mixtures being widely tried on clinical basis.	1979	516610
the effects of sudden airway hypercapnia on the initiation of exercise hyperpnoea in man.	1. in three healthy individuals, the first breath of cycle ergometer exercise was characterized by increases of minute ventilation (ve) and pulmonary capillary co2 output (vco2), with little change of end-tidal pco2, suggesting a concomitant increase of pulmonary blood flow (q) and preservation of v/q status. functional residual capacity fell, depleting lung gas stores of o2 and co2. 2. the following hypothesis purporting to account for the initiation of exercise hyperpnoea was examined (filley, ...	1979	529086
time-course of changes in baroreflex sensitivity during the development of renovascular hypertension in rats [proceedings].		1979	529094
effects of acetaminophen on normal human peripheral blood lymphocytes: enhancement of mitogen- and antigen-stimulated incorporation of tritiated thymidine.	this report describes hitherto unrecognized immunoenhancing properties of acetaminophen on cultured human lymphocytes. the addition of acetaminophen (2.5--300 micrograms/ml) significantly enhanced mitogen-induced blastogenesis. the stimulation of cells by candida albicans, from individuals who were skin-test positive for antigen and two-way responses of mixed lymphocytes, were similarly augmented. cells stimulated in the presence of acetaminophen were comparably enhanced in cultures lasting for ...	1979	535186
an evaluation of the bovine -- onchocerca gibsoni, onchocerca gutturosa model as a tertiary screen for drugs against onchocerca volvulus in man.	in this trial suramin, diethylcarbamazine, trichlorphon, levamisole, mebendazole, melarsonyl potassiu, hoechst 33258 and tinidazole were administered to cattle infected with o. gibsoni and o. gutturosa to determine the usefulness of this screen in predicting the effect of drugs in man against. o. volvulus except for melarsonyl potassium which was macrofilarticidal against o. gutturosa but not o. gibsoni when cattle were slaughtered 6 weeks after treatment. it was concluded that cattle infected w ...	1979	538819
identification of a new allele of es-i segregating in an inbred strain of mice.	a new allele of es-1, designated es-1e, has been identified in the mouse. this allele was discovered segregating among the progeny of a strain dba/2j male and is apparently the result of a spontaneous mutation within this strain. genetic analyses have shown that this mutation is heritable and, further, that both heterozygous and homozygous progeny are viable and fertile. to date, no discernible deleterious effects have been identified as associated with this mutation.	1979	540008
identification of a new allele of es-i segregating in an inbred strain of mice.	a new allele of es-1, designated es-1e, has been identified in the mouse. this allele was discovered segregating among the progeny of a strain dba/2j male and is apparently the result of a spontaneous mutation within this strain. genetic analyses have shown that this mutation is heritable and, further, that both heterozygous and homozygous progeny are viable and fertile. to date, no discernible deleterious effects have been identified as associated with this mutation.	1979	540008
effect of sodium hydroxide upon protein binding to filter paper disks and its significance in the determination of protein in colorimetric and radioisotopic assays.		1979	543545
the spontaneous rate of tumours in the laboratory rat: strain chbb: thom (spf).	the aim of this investigation was to examine the time relationship of the rate of development of spontaneous tumours in the rat, strain chbb: thom (spf). the rats were divided into 6 groups, each of which consisted of 100 male and 100 female animals. the first group was killed at the age of 15 months, and the last group when aged 2 1/2 years. thus the time interval between sacrificing the individual groups was 3 months. spontaneous tumours seldom appear in animals up to 15 months of age except i ...	1979	161861
effect of dietary fats and triiodothyronine administration on the lipid components of serum and tissues in the rat.	twelve groups of rats were included in this study. six groups (3 males and 3 females) received high fat diets containing 20% of either peanut oil, maize oil or lard. the other six groups received the same diets plus triiodothyronine. triiodothyronine t3 added to diets containing peanut oil caused slight increase in total serum lipids in female rats, while in male rats serum total lipids were increased about 20-fold. t3 administration caused almost no change in aortic total and all lipid fraction ...	1979	549273
abrupt (sharp cut) type sensorineural hearing loss--a human temporal bone study--.	histopathology of a case of bilateral sensorineural hearing loss of abrupt (sharp cut) type is reported. while there was a 45 db gap in threshold between 1,000 hz and 2,000 hz bilaterally, the patient had a good hearing at 1,000 hz and lower frequencies. the patient was suffering from takayasu's arteritis. major histopathological findings were as follows: almost complete loss of the outer hair cells from the basal end to 12 mm area in the left cochlea (length: 30.5 mm) and 13 mm in the right (le ...	1979	549560
effect of osteotropic hormones on cartilage metabolism.		1979	218877
transcription of endogenous c-type viruses in resting and proliferating tissues of balb/mo mice.		1979	228474
isolation of foot-and-mouth disease virus messenger rna from membrane-bound polyribosomes and characterization of its 5' and 3' termini.		1979	228483
scanning electron microscope observations of microvascular anastomosis in the rat carotid artery.	microvascular anastomosis is gaining increasing significance in the field of replantation and reconstructive surgery. although traumatic interference is minimized by microsurgery, thrombotic occlusions remain the major reason for clinical failure. with the improvement of suturing technique studies were directed towards the causes of failure using light and scanning electron microscopy. our study was focussed on the latter aspect. the left common carotid artery of 55 albino rats was transsected ...	1979	387900
human plasma angiotensinogen: a review of purification procedures.	the current status of the purification and characterization of human angiotensinogen is reviewed. one problem encountered in the past has been the copurification of a protein with similar porperties. this protein has tentatively been designated alanine-protein. an efficient separation of angiotensinogen and alanine-protein was obtained on a zinc chelate column. alanine-protein has been purified and its amino acid and carbohydrate composition determined. the cooh-terminal amino acid and the nh2-t ...	1979	390363
the fate of transplanted pancreatic islets in the rat.	syngeneic pancreatic islets transplanted into the liver or the spleen reverse streptozotocin-induced diabetes in the rat, but allogeneic islets function only briefly and are rejected. shortly after transplantation, thrombi often form around transplanted tissue, particularly around nonislet tissue that contaminates islet preparations. these thrombi are a source of transient liver injury in recipients of intrahepatic grafts. a few days after transplantation, syngeneic islets injected into the port ...	1979	104625
microscopic changes in rat tongue following experimental cryosurgery.	histological changes were studied in the rat tongue for varying periods of time up to 14 days following the application of a cryoprobe to the dorsal surface of rat tongue. within minutes of the application, focal subepithelial vesiculation and hyperemia occurred. at 3 h there was evidence of damage to capillary walls, resulting in hemorrhage. arterioles and venules were thrombosed and there were degenerative changes in the muscle layer of their walls. at 6 h ventral epithelium showed evidence of ...	1979	108379
study on the significance of bronchial hyperreactivity in the bronchus obstruction after inhalation of cat dander allergen.	the role of bronchial hyperreactivity in the process that leads to bronchial obstruction after inhalation of an allergen was investigated. in 30 asthmatic children selected because of a positive skin test to cat dander allergen, we measured the histamine threshold, the reaction after allergen inhalation, the allergen-specific ige concentration in serum, the lowest allergen concentration to which the intracutaneous skin test was positive (skin titer), and the histamine release of leukocytes after ...	1979	92487
changes in skin collagen polarization-optical properties after contact burn.		1979	92128
guinea pig very low density lipoproteins are a good substrate for lipoprotein lipase.	in contrast to plasma from most other animals, guinea pig plasma causes little or no stimulation of lipoprotein lipase activity. very low density lipoproteins (vldl) isolated by ultracentrifugation of guinea pig serum caused a definite stimulation of lipase activity, whereas the infranatant inhibited the activity. gel filtration in 5 m guanidinium hydrochloride of delipidated vldl demonstrated that the activation was caused by a low molecular weight protein. the vldl themselves were hydrolized a ...	1979	229910
studies on the isolation and characterization of theilerial antigens: particularly on the applicability to passive hemagglutination test.		1979	261988
bcg at the cross roads.		1979	263227
human cell membrane components dominant in t cell lineage: identification and characterization of human tl-like antigens.	cell membrane components that contain beta 2-microglobulin were purified from cells of a human t cell-type leukemia cell line, hpb-all. they contained membrane components that have the same molecular size and the same subunit structure as hla(a,b,c) antigens but are separable from the typical beta 2-microglobulin-containing cell membrane components, i.e., the hla (a,b,c) antigens, by xenoantibody reagents. a sensitive radioimmunoassay was constructed for detection of the t cell membrane componen ...	1979	387877
[ontogenesis of the entorhinal region of the human cerebral cortex].	the ontogenesis of the entorhinal region of the human brain was studied on a series of continuous frontal sections of the brain in 13 pre- and postnatal ages. the sections were stained with crezyl violet. use was made of the quantitative methods. the study revealed some peculiarities in the ontogenetic development of certain subregions and areas of the entorhinal cortex of the human brain. peculiar of the development of the human antorhinal region in the second half of pregnancy is appearance of ...	1979	525118
biochemical properties and drug sensitivity of klebsiella species isolated in lusaka.		1979	544262
vibrio vulnificus (lactose-positive vibrio) and vibrio parahaemolyticus differ in their susceptibilities to human serum.	eleven vibrio vulnificus (lactose-positive vibrio) strains were less susceptible to the bactericidal activity of normal human serum or serum treated with magnesium-ethyleneglycol-bis (beta-aminoethyl ether)-n,n'-tetraacetic acid than were six vibrio parahaemolyticus strains.	1981	6788703
detection of extracellular toxin(s) produced by vibrio vulnificus.	conditions are described for the production, in high titers, a heat-labile, antigenic, extracellular toxin(s) by vibrio vulnificus, a recently recognized human pathogen. bacteriologically sterile culture filtrate preparations obtained from mid-logarithmic-phase cultures of the bacterium possessed cytolytic activity against mammalian erythrocytes, cytotoxic activity for chinese hamster ovary cells, vascular permeability factor activity in guinea pig skin, and lethal activity for mice. the specifi ...	1981	7024134
lethal cold stress of vibrio vulnificus in oysters.	studies were conducted on the survival of vibrio vulnificus, an estuarine human pathogen, in oyster homogenates held at 4 degrees c. results indicated a rapid and dramatic decrease in viability not attributable to either cold shock or the oyster homogenate alone but to a combination of the two. such a decline was not observed with vibrio parahaemolyticus. chilled v. vulnificus cells were unable to repair themselves in brain heart infusion broth at 37 degrees c. v. vulnificus cells incubated on w ...	1981	7224632
acute bacterial myositis caused by vibrio vulnificus.		1981	7241733
edema and hemoconcentration in mice experimentally infected with vibrio vulnificus.	vibrio vulnificus (lactose-positive vibrio), a recently recognized pathogenic marine species, produced extreme hemoconcentration and death within 3 to 6 h after subcutaneous or intraperitoneal injection of 10(8) viable cells into mice; hemotocrit values approached 70% (normal, 45%). about 1 ml of edema fluid accumulated at the site of each subcutaneous injection, and locally increased vascular permeability was demonstrated by a skin bluing assay, using evans blue dye. a corresponding fluid accum ...	1981	7251164
wound infection and septic shock due to vibrio vulnificus.	vibrio vulnificus is an organism commonly found in the marine environment whose pathogenic potential for humans has been recently recognized. two patients are described who developed rapidly progressing wound infections and bacteremia due to this halophilic, lactose-positive vibrio. the clinical manifestations of the resulting infection differed from patterns reported by other authors.	1981	7258496
interaction of vibrio vulnificus with human polymorphonuclear leukocytes: association of virulence with resistance to phagocytosis.	the results of studies described in this report support the ideas that virulence of vibrio vulnificus is associated, at least in part, with resistance to phagocytosis and that the ability of the bacterium to resist phagocytosis results from its possession of an antiphagocytic surface antigen. these conclusions are based on the observations that (1) human polymorphonuclear leukocytes (pmnls) exhibited a significantly weaker chemiluminescent response and phagocytic response when interacting with a ...	1981	7276636
hemolytic reaction of clinical and environmental strains of vibrio vulnificus.	all vibrio vulnificus strains tested (four clinical isolates and eight environmental isolates) hemolyzed human erythrocytes. in contrast to findings with vibrio parahaemolyticus, in which hemolytic activity correlates with isolation from clinical specimens, results from the present study suggest that hemolysis is not usefull in differentiating v. vulnificus strains.	1981	7287896
role of iron in the pathogenesis of vibrio vulnificus infections.	infections with vibrio vulnificus resulting in septicemia and high mortality have been correlated with pre-existing liver disease and hemochromatosis. as these conditions are associated with impaired iron metabolism and as iron availability in the host has been implicated in the pathogenicity of a number of bacterial infections, the role of iron as a possible factor in the pathogenesis of v. vulnificus was examined. injection of mice with iron resulted in a lowering of the 50% lethal dose from 1 ...	1981	7309236
prevention and therapy of serous otitis media by oral decongestant: a double-blind study in pediatric practice.	we studied the efficacy of (1) preventing the development of serous otitis media (som) by using an oral decongestant in children with acute otitis media and (2) treating som with an oral decongestant. in a randomized double-blind study, 190 children were treated for acute otitis media with antibiotics and either pseudoephedrine hydrochloride (sudafed) or placebo. they were evaluated two weeks later by tympanometry and (independently) by clinical evaluation and pneumotoscopy. there were no signif ...	1981	351537
primary nursing: one nurse--one client planning care together.		1981	243765
gastric secretion, gastroesophageal reflux and esophagitis.	neither gastroesophageal reflux nor esophagitis were found to have a clear-cut relationship with gastric secretory output. patients with esophagitis had significantly longer periods of reflux than those without esophagitis. it is concluded that the important factor in the genesis of esophagitis is the duration of contact between the esophageal mucosa with gastric contents rather than gastric secretory output.	1982	242213
[bronchial asthma due to the "trigger mechanism" (foreign bodies in the bronchi; hiatal hernia): presentation of clinical cases].		1982	242070
validity of family informants' ratings of psychiatric patients: general validity.		1982	242027
two dental schools.		1982	351169
diluent composition for use of api 20e in characterizing marine and estuarine bacteria.	nine chemically defined inoculation diluents, with compositions ranging from 0.85% nacl to 35% marine salts, were used to evaluate the influence of diluent composition on the biochemical profiles of 30 marine and estuarine bacterial strains, including species of vibrio, aeromonas, allomonas, and photobacterium. results demonstrated that a 20% marine salts diluent enabled the characterization of halophilic strains normally nonreactive by the api 20e system. furthermore, the use of 20% marine salt ...	1982	7125655
vibrio vulnificus biogroup 2: new biogroup pathogenic for eels.	clinical and nonclinical isolates of the lactose-positive vibrio vulnificus were compared with vibrio strains isolated from lesions on eels (anguilla japonica) cultured commercially in japan. strains were compared phenotypically and antigenically, for pathogenicity to mice and eels, and for genetic relatedness. the strains isolated from diseased eels differed phenotypically from the original species description of v. vulnificus in that they were negative for indole production, ornithine decarbox ...	1982	7138004
disease caused by a marine vibrio--vibrio vulnificus.		1982	7144852
distribution and ecology of vibrio vulnificus and other lactose-fermenting marine vibrios in coastal waters of the southeastern united states.	water, sediment, plankton, and animal samples from five coastal sites from north carolina to georgia were sampled for their lactose-fermenting vibrio populations. over 20% of all vibrios tested were sucrose negative and o-nitrophenyl-beta-d-galactopyranoside (onpg) positive, suggesting identification as the human pathogen vibrio vulnificus. these vibrios were isolated from all sample sites and sources (water, sediment, plankton, and animals). correlations with several of 19 environmental paramet ...	1982	7159083
isolation and characterization of vibrio vulnificus from two florida estuaries.	vibrio vulnificus was enumerated in seawater and shellfish from two florida estuaries at selected seasonal intervals. there were significant fluctuations in the presence and numbers of v. vulnificus. relatively high seawater temperature and salinity favored the presence of v. vulnificus in both seawater and shellfish samples.	1982	7159088
vibrio vulnificus septicemia in a patient with liver cirrhosis.		1982	7187150
[clinical and bacteriological studies on a case with infectious disease caused by vibrio vulnificus].		1982	6819326
statistical evaluation of a quality control method for isolation of pathogenic vibrio species on selected thiosulfate-citrate-bile salts-sucrose agars.	the recovery of vibrio cholerae, vibrio fluvialis, vibrio parahaemolyticus, and vibrio vulnificus, employing eight strains of each species, was studied by using four brands of thiosulfate-citrate-bile salts-sucrose (tcbs) agar prepared according to manufacturers' instructions and following a standardized procedure. a standardized broth inoculum of each strain was placed on duplicate plates of each brand of tcbs agar and also on tryptic soy agar (difco laboratories) containing 1% (wt/vol) nacl, t ...	1982	6761362
collagenolytic activity of vibrio vulnificus: potential contribution to its invasiveness.	vibrio vulnificus (lactose-positive vibrio) produced collagenase when grown in 2% synthetic sea salts supplemented with hydrolyzed casein. the addition of collagen or peptone to the medium increased the level of collagenase production. collagenase activity was inhibited by edta but not by fetal calf serum.	1982	6279515
[a case of hepatoma associated with vibrio vulnificus bacteremia and its bacteriological findings].		1982	6290579
vibrio vulnificus septicemia. isolation of organism from stool and demonstration of antibodies by indirect immunofluorescence.	vibrio vulnificus was isolated from blood and stool cultures from a 65-year-old man who had underlying alcoholic liver disease. the patient had eaten raw oysters the day before he became ill. to our knowledge, this is the first published report of isolation of the organism from stool in a patient with primary septicemia, and it provides support for epidemiologic studies suggesting that the infection is acquired through the gastrointestinal tract by eating raw seafood containing the organism. it ...	1983	6340632
siderophore production by vibrio vulnificus.	previous studies in our laboratory, as well as clinical evidence, have suggested that increased iron levels in the host may be important in infections caused by the halophilic pathogen vibrio vulnificus. to study iron acquisition, we induced siderophore production by growth in a low-iron medium, and biochemical testing indicated the production of both hydroxamate- and phenolate-type siderophores. the siderophores were extracted from growth filtrates with ethyl acetate (for phenolates) and phenol ...	1983	6223882
vibrio vulnificus. a gastronomic hazard.		1983	6572281
spectrum of vibrio infections in a gulf coast community.	infection with vibrio species was diagnosed in 23 patients over a 10-year period in a gulf coast community. species isolated were vibrio vulnificus, v. cholerae, v. parahaemolyticus, and v. alginolyticus. clinical presentations included diarrhea, wound infection, and bacteremia. gastrointestinal tract infection was infrequently diagnosed, despite the routine use of stool culture media appropriate for vibrio isolation. bacteremic infections were severe and occurred only in patients with underlyin ...	1983	6625378
[vibrio vulnificus].		1983	6635466
differential complement activation and susceptibility to human serum bactericidal action by vibrio species.	the ability of vibrio vulnificus to resist human serum bactericidal action and to activate human complement was compared with similar cultures of vibrio cholerae and vibrio parahaemolyticus. both v. vulnificus and v. parahaemolyticus had similar survival rates in sera and were much more resistant to killing than was v. cholerae. in contrast, v. vulnificus activated significantly less serum complement than did v. cholerae and v. parahaemolyticus. the relative ability of v. vulnificus to survive i ...	1983	6642665
[fatal vibrio vulnificus infection in a patient with aplastic anemia].	the patient was a 59-year-old man who had been in hospital suffering from aplastic anemia with transfusion hemosiderosis. sudden onset of weakness, shaking chills and headache was observed after his staying out overnight on july 25, 1981. his temperature was 39.3 degrees c and he complained of abdominal pain and abdominal distension. his blood pressure dropped to a dangerous level and tonic convulsions that had begun in the upper body gradually extended to the whole body and he died 23 hours aft ...	1983	6679624
marine noncholera vibrio infections in florida.	in the past decade, there has been a dramatic increase in the number of reported cases of clinical illness from noncholera (marine) vibrio infections, leading to a greater recognition of this potentially lethal disease. the wide spectrum of pathogenicity of this organism is reflected in the six cases in this report, varying from simple gastroenteritis to focal necrotizing cellulitis to fatal septicemia. we have reviewed the fundamental clinical differences between vibrio vulnificus and other non ...	1983	6828895
extraintestinal infections due to halophilic vibrios.	to compare the clinical and epidemiologic features, we reviewed the hospital records and interviewed 18 patients with extraintestinal infections caused by three species of halophilic vibrios. vibrio vulnificus, the organism most frequently isolated in virginia during the six-year study period, caused primary septicemia in three patients. fifteen patients had soft tissue infections, most of which followed injuries that were contaminated by seawater and mostly caused by v vulnificus and v parahaem ...	1983	6844963
distribution of vibrio vulnificus and other lactose-fermenting vibrios in the marine environment.	during the summer of 1981, 3,887 sucrose-negative vibrios were isolated from seawater, sediment, plankton, and animal samples taken from 80 sites from miami, fla., to portland, maine. of these, 4.2% were able to ferment lactose. the lactose-positive strains isolated from the various samples correlated positively with ph and turbidity of the water, vibrios in the sediment and oysters, and total bacterial counts in oysters. negative correlations were obtained for water salinity. numerical taxonomy ...	1983	6847190
antibiotic efficacy against vibrio vulnificus in the mouse: superiority of tetracycline.	seven antimicrobial agents, all effective against vibrio vulnificus in vitro, were compared for in vivo efficacy in mice experimentally infected with v. vulnificus strain b3547. mice were injected s.c. with 1 x 10(8) cells, and i.p. injection of antimicrobials was begun 1.5 hr later when mice were bacteremic and had edematous lesions at the injection site. the study was done in two phases. phase i was a dose-ranging experiment, using single injections within the range (on a body weight-adjusted ...	1983	6864521
new selective plating medium for isolation of vibrio vulnificus biogroup 1.	a new plating medium (vv agar) has been developed as an alternative to thiosulfate-citrate-bile salts-sucrose (tcbs) agar for the isolation of vibrio vulnificus. salicin (2% wt/vol) is employed as the source of carbohydrate, with potassium tellurite (0.0005% wt/vol), crystal violet (0.00015% wt/vol), oxgall (0.8% wt/vol), and a ph of 8.6 to inhibit growth of gram-positive and gram-negative organisms other than v. vulnificus. because strains of v. vulnificus do not strongly ferment salicin in vv ...	1983	6874897
vibrio vulnificus infection. case report and update since 1970.	vibrio vulnificus infections is being reported with increasing frequency in coastal regions of the united states. raw seafood consumption, particularly raw oysters, and wounds acquired in a marine environment predispose to infection. patients with advanced liver disease are at increased risk of developing septicemia. v. vulnificus is a virulent pathogen producing significant morbidity and mortality; its virulence relates in part to the production of exotoxin. skin lesions occur early in the clin ...	1983	6886115
[case of bacteremic phlegmon due to vibrio vulnificus].		1983	6420485
measures of fitness and demographic stability.	the concepts of entropy and reproductive potential of a genotype were introduced in a previous paper [demetrius, l. (1974) proc. natl. acad. sci. usa 71, 4645-4647] and an analoge of the fundamental theorem of natural selection was derived. this paper relates to entropy of a population with the rate of convergence of the population to the stable age distribution. i show that (i) at maximal entropy, no oscillatory components exist and the birth sequence is unaffected by perturbations in the stabl ...	1983	264691
[fibrous dysplasia].	fibrous dysplasia of bone may occur also in the facial skeleton. main locations are the lateral midface and the mandible. the foci, which are sharply circumscribed in most cases, produce tumour-simulating deformities of single of several facial bones and, in part, disorders of the articulation are bulbar displacements. in contrast to paget's disease, fibrous dysplasia is a disorder of the younger age groups. apart from bony changes, albright's syndrome (which occurs in women only) comprises also ...	1983	272797
[continued education of teachers--reflections about a model of interrelationships].		1983	242401
parathyroid hormone secretion in magnesium deficiency.	the effect of an acute elevation of the serum magnesium concentration on the concentrations of serum immunoreactive parathyroid hormone (ipth) were studied in hypocalcemic hypomagnesemic patients, hyperparathyroid patients, and normal individuals. basal serum ipth concentrations in the hypomagnesemic patients ranged from undetectable to 3 times the upper limit of normal. all hypomagnesemic patients were observed to have an immediate rise in the serum ipth concentration after magnesium administra ...	1984	263326
iatrogenic foreign body.		1984	271282
the ldh virus: an interfering biological contaminant.		1984	263259
[inhibition of premature uterine contractions].	various drugs used to stop premature uterine contractions are discussed in the paper. particular attention is paid to beta-mimetic drugs. the results of ming partusisten, one of beta-mimetic drugs, is presented on the material of 104 patients with threatening immature and premature labour. partusisten was administered in the form of intravenous drip infusion or tablets. during treatment monitoring of the uterine contractility and of foetal heart rate took place. inhibition of the uterine contrac ...	1984	263521
jaw lymphoma in middle east children.	six cases of jaw lymphoma occurring in middle east children between 1971-1976 are reported. while the histological and radiological appearances of the tumours were suggestive of a diagnosis of burkitt's tumour, the middle east tumour failed to respond clinically to treatment which is effective against burkitt's lymphoma. it is believed that these tumours may constitute a separate clinical entity. the identification of the initiating agent should be a matter of urgency, for treatment at present i ...	1984	271017
[results of the treatment of nonlymphoblastic acute leukemia in a pediatric population].	on a prospective fashion during approximately two years, 22 pediatric patients with acute non lymphocytic leukemia were evaluated. of this population the majority had acute mielocytic leukemia, followed by acute myelomonocytic leukemia. absolutely all patients at the time of diagnosis and subsequently every 4 to 6 weeks had a bone marrow aspiration test. when the patients were first seen, 54% of them presented fever; lymph node enlargement was not a common finding. only few of this patients pres ...	1984	270999
kinetic investigation of unfolding and partial refolding of a crab satellite (da-dt)n.	crab (da-dt)n was isolated from the testes of cancer borealis by a procedure involving separation of dna and segregation of the satellite fraction by hg2+ binding/cs2so4 density gradient ultracentrifugation. the titration of crab (da-dt)n samples at 10 degrees indicated a sharp absorbance change at ph 11.98 in agreement with the phm value observed for synthetic poly(da-dt) under identical conditions. the reversal of the titration, however, resulted only in about 50% recovery of the original abso ...	1984	240385
protection of mice against vibrio vulnificus disease by vaccination with surface antigen preparations and anti-surface antigen antisera.	vaccination of mice with either formalin-killed cells or cell extracts of a virulent strain and a weakly virulent strain of vibrio vulnificus or with rabbit antisera (as) against the formalin-killed cells and cell extracts protected against the virulent strain of v. vulnificus. however, the virulent strain vaccines and as elicited a significantly stronger immune response than the weakly virulent strain vaccines and as. adsorption of the as with either the homologous or heterologous formalin-kill ...	1984	6469346
halophilic vibrio species from seafish in senegal.	sucrose-positive and sucrose-negative halophilic vibrio species at counts of up to 10(7)/100 g were isolated from muscles tissue in 27 and 43%, respectively, of 128 seafish from coastal waters in senegal. vibrio parahaemolyticus, including 21% urease-positive strains, was the most common isolate, followed by vibrio alginolyticus, vibrio vulnificus, vibrio damsela, and vibrio fluvialis.	1984	6476829
nucleotide base sequence of vibrionaceae 5 s rrna.	nucleotide base sequences of 5 s rrnas isolated from vibrio vulnificus, vibrio anguillarum, and aeromonas hydrophila were determined. comparisons among these and sequences of 5 s rrnas from other species of vibrionaceae provide information useful in the evaluation of the evolution of bacterial species.	1984	6479333
resistance of vibrio vulnificus to serum bactericidal and opsonizing factors: relation to virulence in suckling mice and humans.	vibrio vulnificus causes soft-tissue infections, gastrointestinal disease, and severe sepsis in humans. bacterial and host factors in virulence have remained poorly defined. we found that blood culture isolates of v. vulnificus were completely resistant to the bactericidal effects of 10% normal human serum, in contrast to soft-tissue and environmental isolates that showed a mean 2.6 log10 decline during 120 min of incubation. following opsonization by 10% normal human serum, mean uptake of blood ...	1984	6481186
vibrio vulnificus endometritis.	vibrio vulnificus most frequently causes wound infections contracted after exposure to seawater or primary septicemias resulting from the consumption of raw oysters. we report a case of endometritis caused by v. vulnificus. the infection was apparently acquired during the act of sexual intercourse in seawater in an area in which v. vulnificus has been frequently isolated. the efficacy of treatment with an antimicrobial regimen which included tetracycline is discussed.	1984	6490813
necrotising fasciitis caused by vibrio vulnificus.	a case of necrotising fasciitis caused by vibrio vulnificus is described. the need for early recognition and aggressive surgical treatment are highlighted, and the necrotising infections due to v vulnificus described in the published work are reviewed.	1984	6501592
evidence for the presence of a capsule in vibrio vulnificus.	vibrio vulnificus strain fcc, isolated from a patient with a wound infection, and reference strain atcc 27562, were examined by electron microscopy for the presence of capsules. both strains had a layer heavily stained with ruthenium red. the number of stained cells was high in strain fcc and low in strain atcc 27562. the proportion of stained cells correlated with virulence against mice and with susceptibility to the bactericidal activity of normal human serum. rapid freezing and substitution f ...	1984	6512503
on the serology of vibrio vulnificus.	the serology of 70 strains of vibrio vulnificus was studied. seven o-antigenic groups were defined among them and it was shown that the h antigens of all the strains were identical. a heat-labile masked antigen, which inhibits o agglutination, was found in some strains. as all o antisera for v. vulnificus contained some r antibody, all diagnostic o sera must be absorbed with r organisms before use.	1984	6536784
[a case report of vibrio vulnificus infection with successful treatment].		1984	6086784
comparative studies and laboratory diagnosis of vibrio vulnificus, an invasive vibrio sp.	vibrio vulnificus was isolated from a bacteremic patient. this strain, together with other isolates of v. vulnificus, was compared with v. alginolyticus, v. fluvialis, and v. parahaemolyticus with regard to growth characteristics on enteric agar media (enabling isolation and identification) and production of exoenzymes which could correlate with invasive potential. v. vulnificus grew well on macconkey. endo, xylose-lysine deoxycholate, and hektoen enteric agar plates. because v. vulnificus colon ...	1984	6699140
wound infections caused by vibrio vulnificus, a marine vibrio, in inland areas of the united states.	vibrio vulnificus is a halophilic marine vibrio which may produce infection in wounds exposed to seawater or raw shellfish. the centers for disease control has received two isolates from wounds exposed to inland waters, a new mexico creek and an oklahoma reservoir. halophilic organisms were recovered from both the creek and the reservoir, and the water in both sites was found to be brackish. both clinical isolates of v. vulnificus grew in salt concentrations as low as those found in the creek an ...	1984	6699148
cytolytic activity and virulence of vibrio damsela.	a correlation was observed between the ability of 19 isolates of vibrio damsela, a halophilic bacterium recently recognized as a human pathogen, to cause disease in mice and to produce large amounts of a cytolytic toxin in vitro. the yield of toxin in the culture supernatant fluids was optimal during the mid- and late-logarithmic phases of growth in medium containing 0.5% na+ ion, was stable during the stationary growth phase, and was significantly reduced in culture medium containing greater th ...	1984	6715036
clinical features and an epidemiological study of vibrio vulnificus infections.	vibrio vulnificus, a recently described halophilic vibrio species, has been isolated from the blood, wounds, and other skin lesions of patients with primary sepsis or wound infections. because no study of risk factors for infections with v vulnificus has been reported, a case-control study was performed with the 30 patients from whom v vulnificus isolates were recently submitted to the centers for disease control (atlanta, georgia). patients with primary sepsis were more likely than controls to ...	1984	6725989
role of heme compounds and haptoglobin in vibrio vulnificus pathogenicity.	an induced peritonitis model was employed in mice to determine whether heme-containing molecules enhance the lethality of infections by vibrio vulnificus. the lethality of intraperitoneal (ip) inocula of the bacteria was increased by concurrent injections (ip) of hemoglobin, methemoglobin, or hematin, but not by myoglobin. similar results were obtained in mice with phenylhydrazine-induced hemoglobinemia, in which after ip injections of v. vulnificus, a direct correlation between lethality and le ...	1984	6746093
extracellular phospholipase a2 and lysophospholipase produced by vibrio vulnificus.	phospholipase a2 and lysophospholipase activities were detected in the culture supernatant fluids of a virulent strain of vibrio vulnificus. the phospholipase a2 was inactivated by heating at 56 degrees c for 30 min, had an apparent molecular weight of greater than or equal to 80,000 (estimated by gel filtration with sephadex g-75), and a pi of ca. 5.0. phospholipid hydrolysis was unaffected by ca2+ or ethylene glycol-bis(beta-aminoethyl ether)-n,n-tetraacetic acid and was optimal at ph 5.0 to 5 ...	1984	6746100
vibrio vulnificus septicaemia.	a patient, who had been receiving treatment for refractory anaemia with excess of myeloblasts for three years, developed septic shock due to vibrio vulnificus septicaemia. the infection was believed to have been introduced with the ingestion of raw oysters. this organism is comparatively rare, but it can cause serious infection, and is known to be capable of very rapid tissue invasion.	1984	6749004
vibrio hand infections: a case report and review of the literature.	a case of vibrio vulnificus infection of the hand is presented. the role of vibrio species as primary pathogens in infections associated with exposure to a marine environment is discussed.	1984	6386958
de novo expression of t cell markers on theileria parva-transformed lymphoblasts in cattle.	we describe monoclonal antibodies that detect two new membrane antigens on bovine t cells. one molecule is only expressed on activated t cells and has a m.w. of 100,000. the other antigen is a glycoprotein that is precipitated as two bands of m.w. 150,000 and 158,000 and is expressed on a subpopulation of t cells and all myeloid cells. we show that when bovine lymphocytes are transformed by the protozoan parasite theileria parva, both antigens become expressed on the cell surface. the infected c ...	1985	3934278
topographic organization of projections from the amygdala to the hypothalamus of the rat.	afferent fibers from the amygdala to subdivisions of lateral, ventromedial and dorsomedial hypothalamic nuclei were investigated in rat by retrograde transport of horseradish peroxidase. small (intranuclear size) peroxidase deposits were placed in hypothalamic nuclei by iontophoresis of a tracer solution containing poly-l-alpha-ornithine which greatly limited diffusion. the medial, central and amygdalo-hippocampal nuclei of the amygdala were found to be the major donors of amygdaloid afferent fi ...	1985	4022458