Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| the mechanisms of synergistic effect of antibiotics. a mechanism of synergism, cephaloridine with gentamicin on cephaloridine resistant gram negative bacilli. | twelve strains out of 75 gram negative rods, which were isolated at the clinical laboratory in the hospital, were highly resistant to cephaloridine (cer) and relatively sensitive to gentamicin (gm). nine strains out of the 12 strains revealed synergistic effect when small doses of gm were used together with cer. a mechanism of synergistic effect on enterobacter cloacae, 1 strain of the 9 strains, was studied through change of beta-lactamase activities. the levels of viable cell count decreased w ... | 1982 | 6983591 |
| biotyping of enterobacter cloacae. | a biotyping scheme for enterobacter cloacae is proposed. tests with seven substrates that gave reliable, reproducible results with 110 isolates of e cloacae formed the basis of the biotyping scheme which would allow recognition of 128 potential biotypes. | 1982 | 7050186 |
| influence of escherichia coli, klebsiella pneumoniae and proteus vulgaris on the mortality pattern of mice after lethal irradiation with gamma rays. | the mortality patterns and the ld50/30 for mice free from enterobacteriaceae, mice contaminated with enterobacter cloacae, and mice inoculated with escherichia coli, klebsiella pneumoniae or proteus vulgaris were examined after whole-body irradiation with gamma rays. no clear differences were observed among the infected groups, but there were clear differences between then and those negative for enterobacteriaceae. the ld50/30 of enterobacteriaceae-positive mice was similar to that for conventio ... | 1982 | 7038292 |
| antibacterial and antimycotic effect of a newly discovered secretion from larvae of an endoparasitic insect, pimpla turionellae l. (hym.). | the larvae of pimpla turionellae, that develop in pupae of various lepidoptera, discharged through their anus up to 8 microliters/h of a hyaline liquid, which is termed "anal secretion". it exerted a strong bacteriostatic effect on enterobacter cloacae, a highly virulent intestinal microorganism isolated from the midgut of the host pupa, pieris brassicae. growth inhibition of escherichia coli, micrococcus luteus and pseudomonas phaseolicola was also evident, but less pronounced. inhibition depen ... | 1982 | 7171286 |
| mutational enzymatic resistance of enterobacter species to beta-lactam antibiotics. | mutants with enhanced beta-lactam resistance were selected from strains of enterobacter cloacae and e. aerogenes by using three antibiotics. high-level beta-lactamase-producing mutants had similar degrees of increased resistance, enzyme substrate profiles, and isoelectric (pi) values irrespective of the selective agent. reverse mutants from a resistant e. cloacae mutant regained the susceptibility pattern originally exhibited by the wild type, or were of enhanced susceptibility, and no longer ex ... | 1982 | 6979311 |
| resistance to cefamandole: derepression of beta-lactamases by cefoxitin and mutation in enterobacter cloacae. | studies were performed to characterize resistance to cefamandole in two strains of enterobacter cloacae. susceptible wild-type cells were exposed either to cefamandole to select stably resistant mutants or to cefoxitin to induce unstable resistance. the two types of resistant cells inactivated cefamandole, and their beta-lactamases had identical isoelectric focusing patterns and substrate profiles. studies of the beta-lactamases of these resistant cells indicated that the enzymes belonged to the ... | 1982 | 6979593 |
| enterobacter cloacae: bacteremia, epidemiology, and antibiotic resistance. | 1982 | 7071456 | |
| simple screening method for gram-positive bacterial beta-lactam antibiotic tolerance on routine laboratory bauer-kirby antibiogram plates. | a simple screening method served to detect beta-lactam antibiotic-tolerant variants of clinical isolates and laboratory control strains of staphylococcus aureus, s. epidermis, group b beta-hemolytic streptococci, and listeria monocytogenes. the beta-lactamase(s) of a multiple drug-resistant strain of enterobacter cloacae (isolate no. 19) yielded most consistent results as compared with several other beta-lactamase producers; the e. cloacae beta-lactamase(s) was neutralized by clavulanic acid. sp ... | 1982 | 7075323 |
| sq 26,180, a novel monobactam. i taxonomy, fermentation and biological properties. | strains of chromobacterium violaceum, isolated from various environments, were found to produce a novel monocyclic beta-lactam antibiotic. the antibiotic, sq 26,180 was weakly active against gram-positive and gram-negative bacteria with the exception of mutants hypersensitive to beta-lactam antibiotics. the compound was highly stable to beta-lactamases and acted as an inhibitor of the p99 enzyme from enterobacter cloacae. sq 26,180 showed affinity for penicillin-binding proteins 1a, 4 and 5/6 of ... | 1982 | 6978877 |
| potent cephalosporinase inhibitors: 7 beta-[2-(1, 3-dithiolan-2-ylidene) acetamido] cephalosporins and related compounds. | cephalosporins possessing a 1, 3-dithiolane, 1, 3-dithiane, or 1, 3-dithietane ring on their 7 beta-substituents showed potent inhibitory activity against cephaloridine hydrolysis by cephalosporinases purified from proteus morganii, proteus rettgeri, and proteus inconstans, which were not inhibited by clavulanic acid, a well-known beta-lactamase inhibitor. the mode of inhibition was competitive. the dithiolane cephalosporins themselves were stable against hydrolysis by the beta-lactamases tested ... | 1982 | 6979310 |
| in vitro activity and beta-lactamase stability of n-formimidoyl thienamycin compared to that of second and third generation cephalosporins. | n-formimidoyl thienamycin (mk0787) was found to be active against 21 gram-negative isolates, selected for their beta-lactamase production. none of the crude beta-lactamases could hydrolyze mk0787 or cefoxitin, in contrast to cefotaxime which was moderately attacked by a number of enzymes. mk0787 behaved as a moderate inhibitor of most beta-lactamases, whereas cefoxitin and cefotaxime were strong inhibitors of cephalosporinases but not of broad-spectrum enzymes. the new compound had good penetrat ... | 1982 | 6981493 |
| [haemophilus parainfluenza infection followed by enterobacter cloacae infection in a newborn]. | 1982 | 6982032 | |
| antagonism of carbenicillin and cefamandole by cefoxitin in treatment of experimental infections in mice. | the ability of cefoxitin to antagonize the in vivo efficacy of cefamandole and carbenicillin as predicted by in vitro assays was analyzed in experimental infections in mice. cefoxitin was administered in a nonprotective dose either at the time of challenge or simultaneously with the protective drug, 1 and 3.5 h postchallenge. in mice infected with enterobacter cloacae, median 50% protective doses of cefamandole and carbenicillin were markedly increased by cefoxitin, especially when the latter wa ... | 1982 | 6921959 |
| resistance types in enterobacter cloacae. occurrence and resistance to ampicillin, carbenicillin, cephalothin and mecillinam. transfer of ampicillin resistance. | an investigation of the resistance types in enterobacter cloacae is presented. the frequency of the different resistance types was determined. the strains were divided into three groups according to sensitivity to penicillin derivatives. the ampicillin-carbenicillin-sensitive (a-s/ca-s) group 1 comprised 20% of the e. cloacae strains received in this laboratory. the ampicillin resistant-carbenicillin-sensitive (a-r/ca-s) group 2 comprised 38.5% of the strains and the a-r/ca-r group 3 comprised 4 ... | 1982 | 6922669 |
| recommended amikacin doses in newborns often produce excessive serum levels. | emergence of a multiply drug resistant enterobacter cloacae during a seven-week period in 1980 caused amikacin to become the aminoglycoside of choice in the initial management of suspected sepsis in a neonatal intensive care unit. recommended doses (7.5-10 mg/kg loading; 15 mg/kg in two divided doses iv) were given to 5 infants < or = 1,000 gm and to 13 larger babies. trough levels 11.5 hours after a dose were 16.6 +/- 11.9 microg/ml in infants < or = 1,000 gm and 6.5 +/- 4.3 microg/ml in the la ... | 1982 | 12760404 |
| [spontaneous chylothorax in intensive therapy of a very low-weight newborn infant with septicemia caused by enterobacter cloacae]. | 1983 | 6835182 | |
| transient bacteremia following endoscopic injection sclerotherapy of esophageal varices. | the incidence of transient bacteremia following endoscopic injection sclerotherapy of esophageal varices was evaluated in 18 patients subjected to 40 sessions of injection sclerotherapy. blood cultures were obtained before sclerotherapy and at five minutes, 30 minutes, and 24 hours after sclerotherapy. the injectors as well as the endoscope were cultured before and after the procedure. blood cultures were positive in two patients after injection sclerotherapy (enterobacter cloacae and staphyloco ... | 1983 | 6870408 |
| retrospective analysis of plasmid patterns in a study of burn unit outbreaks of infection due to enterobacter cloacae. | to evaluate the usefulness of plasmid pattern analysis as an epidemiologic tool and to determine the mechanism of resistance to silver sulfadiazine and mafenide acetate, silver sulfadiazine-resistant, mafenide acetate-resistant enterobacter cloacae isolates from a 1976 outbreak of infections in a burn unit (group i) were analyzed retrospectively. these strains were compared with various e cloacae isolates (groups ii-v), including e cloacae isolates from a more recent (1982) burn unit outbreak (g ... | 1983 | 6886483 |
| effect of hydrazines on substrate utilization by a strain of enterobacter cloacae. | 1983 | 6850140 | |
| analysis of eight cases of neonatal meningitis and sepsis due to enterobacter sakazakii. | eight cases of neonatal meningitis due to enterobacter sakazakii (formerly known as yellow-pigmented enterobacter cloacae) which occurred in the netherlands during the last 6 years were investigated retrospectively. two patients had necrotizing enterocolitis and meningitis simultaneously. despite treatment (in most cases with ampicillin and gentamicin), the fatality rate was 75%. strains were much more susceptible to some of the new beta-lactam antibiotics than to ampicillin. a mode of transmiss ... | 1983 | 6885983 |
| crystallographic data for the beta-lactamase from enterobacter cloacae p99. | the beta-lactamase from enterobacter cloacae p99 has been crystallized from polyethylene glycol solution at ph 7. x-ray examination of the orthorhombic crystals shows the space group is p2(1)2(1)2 with unit cell dimensions a = 77.4 a, b = 69.4 a, and c = 63.6 a. there is one molecule of molecular weight 39,000 in the asymmetric unit. | 1983 | 6606712 |
| the in-vitro activity of o-demethylfortimicin. | the activity of o-demethylfortimicin against ampicillin, cefazolin and carbenicillin resistant bacteria was determined. o-demethylfortimicin showed excellent in-vitro activity against escherichia coli, klebsiella pneumoniae, enterobacter cloacae, ent. agglomerans, ent. aerogenes, citrobacter freundii, proteus vulgaris, morganella, and providencia inhibiting these organisms at less than or equal to 3.1 mg/l. it was particularly effective against ent. cloacae and serratia marcescens that were resi ... | 1983 | 6833173 |
| in vivo selection of resistance to multiple cephalosporins by enterobacter cloacae. | 1983 | 6833801 | |
| [in vitro antibacterial activity of cefoperazone]. | the in vitro antibacterial activities of cefoperazone (cpz) against clinical isolates including various beta-lactamase-producing strains were studied and compared with those of cefotiam (ctm). cpz had a broad spectrum against gram-negative and gram-positive bacteria. especially, cpz showed apparently more potent antibacterial activities than ctm against enterobacter cloacae, serratia marcescens, and pseudomonas aeruginosa. however, cpz was less active than ctm against staphylococcus aureus and p ... | 1983 | 6609251 |
| [taxonomic study of free nitrogen-fixing bacteria isolated from the endorhizosphere of rice]. | twenty strains of free-living n2-fixing bacteria, isolated from the endorhizosphere of rice in rice soils of senegal, were studied on the basis of 259 morphological, physiological, biochemical and nutritional characters. half of them were gram-negative small rods with polar flagella and showing a strictly respiratory metabolism; they were characteristic of the genus pseudomonas. a first group of 6 strains was related to the p. cepacia-p. marginata group characterized by lophotrichous flagella; t ... | 1983 | 6651126 |
| combined defibrinated human blood and antimicrobial drug activities against enterobacter cloacae. | the combinations of 11 antimicrobial drugs and fresh human defibrinated blood were examined for potential additive effects against several isolates of enterobacter cloacae recovered from patients with bacteremia or meningitis. aminoglycosides (amikacin, gentamicin, netilmicin) proved most efficacious, followed by cephalosporins (lamoxactam, cefotaxime, ceftizoxime) and ureidopenicillins (mezlocillin, piperacillin). nalidixic acid, nitrofurantoin, and cotrimoxazole yielded indifferent effects. th ... | 1983 | 6653172 |
| infection in artificial blood pump implantation. | infection has been observed in artificial heart experimentation to be of early onset and generally within the first 2 postoperative weeks. the organisms most often detected in blood cultures were pseudomonas aeruginosa, enterobacter cloacae, e. coli and enterococcus, all of which are intestinal species. contamination is thus thought to be the most plausible cause of perioperative infection. absolute sterility must be maintained in animal care areas and blood access to these animals is to be mini ... | 1983 | 6673282 |
| [change in the vaginal smear cycle following conventionalization and monocontamination of germ-free rats with enterobacter cloacae]. | the relationship between the microbial organism infection and the vaginal smear cycle was investigated using 12 germfree wistar imamichi rats at 50 days of age. germfree rats exhibited continuous vaginal cornification which occasionally interrupted by the appearance of nucleated epithelial cells. however, leukocytes which are characteristic of the metestrus and diestrus stage in conventional rats were not observed in the vaginal smear of these animals. at 70 days of age, 8 animals were taken out ... | 1983 | 6686559 |
| in vitro antibacterial activity of sm-1652, a new broad-spectrum cephalosporin with antipseudomonal activity. | sm-1652 (sodium 7-[d(-)-alpha-(4-hydroxy-6-methylpyridine-3-carboxamido)-alpha-(4-hydroxyphenyl)acetamido]-3-[(1-methyl-1h-tetrazol-5-yl) thiomethyl]-3-cephem-4-carboxylate) is a new semisynthetic cephalosporin derivative with a broad spectrum of antibacterial activity. its in vitro activity against gram-positive bacteria was comparable to that of cefazolin. sm-1652 exceeded cefazolin in potency and broadness of antibacterial activity against such enterobacteriaceae as indole-positive proteus sp ... | 1983 | 6601470 |
| synthesis and beta-lactamase inhibitory activities of some clavulanic acid analogues. | clavulanic acid analogs lacking the c-3 carboxyl group are potent inhibitors of both plasmid and chromosomally mediated beta-lactamases. they exhibit only low intrinsic anti-bacterial activity, but potentiate the activity of ampicillin and cephaloridine against beta-lactamase producing escherichia coli and enterobacter cloacae in vitro. no synergism was observed in beta-lactamase negative strains. the e. coli tem 1 and the e. cloacae p99 enzymes are inhibited in a progressive and irreversible ma ... | 1983 | 6602120 |
| nonspecific induction of beta-lactamase in enterobacter cloacae. | since the introduction of the new beta-lactamase-stable beta-lactam compounds, inducible beta-lactamases have become increasingly important clinically [1]. it has recently been pointed out that most beta-lactam antibiotics appear to be affected by these derepressed enzymes either by hydrolysis or by the nonhydrolytic barrier mechanism [2]. until now, it has generally been assumed that beta-lactamases are induced only by the beta-lactam compounds themselves. we investigated an e cloacae strain th ... | 1983 | 6605393 |
| differentiation of resistance determinants to cefamandole and cefoxitin in enterobacter cloacae strains. | the mechanism of resistance to cefamandole and cefoxitin was investigated in enterobacter cloacae with the aid of cefamandole-resistant variants and their derived beta-lactamase-deficient mutants. cefamandole-resistant variants were easily obtained from clinical isolates by direct selection. massive beta-lactamase production seemed to be the underlying resistance mechanism, although lack of penetrability may further substantiate this resistance. the mechanism of resistance to cefoxitin in parent ... | 1983 | 6606106 |
| hr 810, a cephalosporin with low affinity for enterobacter cloacae beta-lactamase. | 1983 | 6605247 | |
| antibacterial activity of cefoperazone alone and in combination against cephalosporinase-producing enterobacter cloacae. | the activity of cefoperazone against a strain with an inducible cephalosporinase and a mutant that produces the enzyme constitutively indicates that the low inducer activity of this antibiotic plays an important role in its activity against enterobacter cloacae. | 1983 | 6605112 |
| in vitro evaluation of the bactec resin-containing blood culture bottle. | the bactec resin-containing blood culture bottle (16b; johnston laboratories) was designed to bind antibiotics and to support bacterial growth. however, only modest increases in the recovery rates of pathogens have been found in clinical studies. this in vitro study evaluated the ability of the 16b to recover organisms from human serum containing clinically achievable concentrations of antibiotics. escherichia coli, enterobacter cloacae, klebsiella pneumoniae, pseudomonas aeruginosa, haemophilus ... | 1983 | 6874903 |
| comparative study of fosfomycin activity in mueller-hinton media and in tissues. | fosfomycin utilizes two uptake systems as ways of entry into microorganisms: the l-a-glycerophosphate and the hexose phosphate transport system. the latter is inducible by glucose-6-phosphate. the relationship between glucose-6-phosphate (concentration range 0-100 mg/l) and the susceptibility of staphylococcus aureus was studied in mueller-hinton broth. an almost maximal enhancement of fosfomycin activity was found at 25 mg/l glucose-6-phosphate. fosfomycin activity against staph. aureus, escher ... | 1983 | 6885678 |
| effects of selected hydrazines on the early death rates of enterobacter cloacae. | 1983 | 6626761 | |
| two new monobactam antibiotics produced by a flexibacter sp. i. taxonomy, fermentation, isolation and biological properties. | two new beta-lactam antibiotics, namely sq 28,502 and sq 28,503, have been isolated from fermentations of a flexibacter sp. they are demethoxy monobactams with oligopeptide side chains and have molecular weights of 1,462 and 1,446, respectively. these beta-lactams show a high degree of stability to a variety of beta-lactamases and act as potent irreversible inactivators of p99 beta-lactamase from enterobacter cloacae. they exhibit weak antibacterial activity. | 1983 | 6643274 |
| laboratory diagnosis of bacteremia by headspace gas-liquid chromatography. | the growth of staphylococcus aureus, streptococcus pneumoniae, s. fecalis, s. sanguis, s. bovis, s. mitior, s. agalactiae, escherichia coli, a-d group, klebsiella aerogenes, k. oxytoca, enterobacter cloacae, proteus mirabilis, serratia marcescens, pasteurella multocida or listeria monocytogenes in 83 blood cultures was detected in a 1.5-min analysis using head-space gas-liquid chromatography. two hundred and twenty-four blood cultures in which there was no growth of micro-organisms were negative ... | 1983 | 6888963 |
| o serotyping scheme for enterobacter cloacae. | a serotyping scheme for enterobacter cloacae based on heat-stable somatic antigens is described. a total of 28 antisera were prepared in rabbits, and titers of agglutinins were high (greater than 640). some cross-reactions were observed, and 11 sera required absorption before routine use. of 300 clinical isolates from 66 hospitals, 77.6% were typable, 11.4% were not agglutinated by any of the sera, and 11.0% were autoagglutinable in saline. the eight most frequent serotypes were o3 (21.3%), o8 ( ... | 1983 | 6643660 |
| serratia ficaria isolated from a leg ulcer. | serratia ficaria was isolated from culture of a leg ulcer of a 44-year-old woman who had venous insufficiency and alcoholic cirrhosis. although pseudomonas maltophilia, p acidovorans, and enterobacter cloacae were also present, s ficaria was isolated in large numbers and was considered to contribute significantly to this infection. this represents the third known clinical isolation of this bacterium. | 1983 | 6648629 |
| antibacterial activity of aztreonam: a synthetic monobactam. a comparative study with thirteen other antibiotics. | the in vitro activity of aztreoman (sq 26, 776), a new monocyclic beta-lactam antimicrobial agent, was determined against 1720 bacteria, all clinical isolates, and compared with that of thirteen beta-lactam and aminoglycoside antibiotics. aztreonam inhibited 90% of citrobacter diversus, citrobacter freundii, enterobacter agglomerans, e. coli, klebsiella pneumoniae, proteus mirabilis, proteus morganii, proteus rettgeri, proteus vulgaris and salmonella sp. by less than or equal to 0.4 micrograms m ... | 1983 | 6684718 |
| salmonella and other enterobacteriaceae found in commercial poultry feed. | poultry feed (mash and pelleted) and meat and bone meal samples were collected from commercial mills. all samples were analyzed for enterobacteriaceae count (ent) and salmonella. the genus and species of the various enterobacteriaceae present were also determined. the average ent for mash, pelleted, and meal samples was log 4.1, .8, and 1.8/g, respectively. enterobacteriaceae were present in 100, 60, and 92% and salmonella in 58, 0, and 92% of the mash, pelleted, and meal samples, respectively. ... | 1983 | 6657560 |
| superinfections in herpes simplex keratitis. | we reviewed 15 cases of culture-proven corneal superinfections in 15 patients (eight men and seven women ranging in age from 41 to 86 years) with recurrent herpes simplex keratitis. the factors that appeared to increase the risk of superinfection were the presence of an epithelial defect (found in all 15 cases), a history of recurrent herpetic keratouveitis (found in ten cases), and the use of topical corticosteroids (found in 13 cases). eight of the 15 patients were taking antibiotics at the ti ... | 1983 | 6614114 |
| cefamandole therapy in hand infections. | hand lacerations, especially when inadequately treated, may result in infections caused by aerobic or anaerobic bacteria. anaerobic infections most commonly result from human bite injuries in which there is contact between hand and mouth. the search continues for an ideal antibiotic to employ when anaerobic organisms are suspected. in this study cefamandole, a new cephalosporin antibiotic, was employed whenever anaerobic hand infections were suspected following trauma. in each patient quantitati ... | 1983 | 6415153 |
| inactivation of cephalosporins by beta-lactamases of gram-negative rods. | intracellular beta-lactamase activity of gram-negative rods (four pseudomonas aeruginosa strains, one strain each of enterobacter cloacae, proteus rettgeri, providencia stuartii and serratia marcescens) was greatly increased by subinhibitory concentrations of cefoxitin, with the exception of one p. aeruginosa strain. cefotaxime, cefoperazone and ceftazidime were much less effective as enzyme inducers in these strains. a reduction in beta-lactamase activity after pre-incubation with cephalosporin ... | 1983 | 6339417 |
| ceftazidime therapy of serious bacterial infections. | ceftazidime, a new broad-spectrum cephalosporin, was administered to 30 patients with serious bacterial infections in a randomized dosing trial with daily doses of 1.5 or 3 g. both regimens were equally efficacious, with satisfactory clinical responses in 28 instances (93%) and microbiological eradication of 79% of initial bacterial isolates. the development of resistance to ceftazidime during therapy was observed in three cases (enterobacter agglomerans, enterobacter cloacae, and pseudomonas ae ... | 1983 | 6340601 |
| [the antibiotic agent azthreonam: studies on plasmid-dependent resistance formation]. | two mechanisms can be assumed that are responsible for the stability of azthreonam against the attack of beta-lactamases: first, azthreonam lacks binding to the enzyme protein and second, rate of hydrolysis is extremely low, resulting even in inhibition of enzyme activity. enzyme kinetics were studied from highly purified enzymes: azthreonam did not bind to the tem-1 enzyme, whereas the compound revealed a time-dependent inhibition of the chromosomally mediated enterobacter cloacae enzyme. with ... | 1983 | 6341212 |
| an outbreak of gentamicin-resistant enterobacter cloacae infections in a pediatric intensive care unit. | the intensive care unit at children's medical center in dallas is a medical-surgical unit that cares for pediatric patients of all ages. in 1978 an outbreak of infections occurred that was caused by a gentamicin-resistant strain of enterobacter cloacae. thirty of the 34 patients involved in the outbreak were neonates. six patients developed bacteremia, five of them neonates. the neonates who became infected were significantly smaller (less 1500 g) and more premature (less than 35 weeks) than con ... | 1983 | 6553023 |
| in-vitro activity of cefotetan and other cephalosporins against multiresistant strains of enterobacteriaceae. | the activity of cefotetan against multiresistant strains of escherichia coli and klebsiella aerogenes was comparable with that of cefotaxime and ceftazidime, the mean mics being 0.11 and 0.06 mg/l, respectively. multiresistant strains of enterobacter cloacae showed a high level of resistance to cefotetan in common with other cephalosporins such as cefuroxime, cefamandole and cefoxitin, but were sensitive to ceftazidime and cefotaxime. | 1983 | 6573310 |
| direct dilution sampling, quantitation, and microbial assessment of open-system ventilation circuits in intensive care units. | in a systematic approach, 37 duplicate samples of open system circuits (bennett ma-1 ventilators) of patients in medical and surgical intensive care units were processed by direct and serial (apha guidelines) dilutions. the paired difference test on 15 of the in-use circuitry solution samples indicated no difference between the direct and serial dilution methods (p less than 0.001). seventy-seven additional respiratory therapy circuitry samples from similar intensive care patients were analyzed ... | 1983 | 6575015 |
| cefotetan: profile of in-vitro activity. | cefotetan, a novel 7 alpha-methoxy cephalosporin, was shown to be comparable to other third-generation cephalosporins when tested in vitro against 1063 gram-negative clinical isolates of 11 species. ninety per cent of all isolates of escherichia coli, klebsiella, proteus mirabilis, proteus vulgaris, proteus rettgeri, providencia stuartii, serratia marcescens and citrobacter freundii were inhibited by concentrations of cefotetan between 0.07 and 3.2 mg/l. activity against gram-positive cocci was ... | 1983 | 6601656 |
| characterization of beta-lactamase induction in enterobacter cloacae. | the induction of beta-lactamase was studied in a strain of enterobacter cloacae. a wide variety of beta-lactam compounds were found to induce beta-lactamase in this organism, and the degree of induction was directly related to the stability of the inducer to degradation by the enzyme. the kinetics of the induction process were consistent with a system normally under repressor control, suggesting a direct interaction of the beta-lactam compound with a repressor protein in the e. cloacae cells. al ... | 1983 | 6402977 |
| selection of variants of gram-negative bacteria with elevated production of type 1 beta-lactamase. | variants of pseudomonas aeruginosa, citrobacter freundii and enterobacter cloacae were isolated that produced elevated levels of type 1 beta-lactamase. the variants were readily isolated on antibiotic-containing agar and showed resistance to a wide range of beta-lactam antibiotics including some regarded as being relatively stable to the beta-lactamase produced. | 1983 | 6411674 |
| in vitro antibacterial activity and beta-lactamase stability of e-0702, a new cephalosporin. | the in vitro activity of e-0702 was compared with the in vitro activity of cefotaxime, ceftazidime, moxalactam, and aztreonam against 600 gram-positive and gram-negative aerobic and anaerobic isolates. e-0702 had a minimal inhibitory concentration for 50% of isolates (mic50) of 25 micrograms for staphylococcus aureus, 50 micrograms for staphylococcus epidermidis, and 1.6 to 3.1 micrograms for streptococci, with streptococcus faecalis resistant. e-0702 had mic50s against escherichia coli, klebsie ... | 1983 | 6605718 |
| cefotetan: antimicrobial activity in-vitro compared with that of cefotaxime. | the antimicrobial activity of cefotetan and cefotaxime were compared in vitro against 547 strains of aerobes and 24 strains of bacteroides fragilis. the strains were recent clinical isolates from 20 hospitals. cefotetan was found to exhibit an activity two- to fourfold lower than that of cefotaxime against most of the enterobacteriaceae. about half the number of enterobacter aerogenes and enterobacter cloacae strains resistant to cefotetan were resistant also to cefotaxime. cefotetan was more ac ... | 1983 | 6302064 |
| hydrogen peroxide-mediated antagonism against serratia marcescens by streptococcus mitis. | the alpha-hemolytic streptococcus mitis strain no. 17-1, isolated from the oral cavity of an healthy female adult, antagonized the growth of all 24 test strains of serratia marcescens examined; furthermore, this strain inhibited the growth of various strains of staphylococcus aureus, s. epidermidis, streptococcus pyogenes, s. agalactiae, s. pneumoniae, haemophilus influenzae, listeria monocytogenes, and corynebacterium diphtheriae. however, strans of escherichia coli, enterobacter cloacae, klebs ... | 1983 | 6372321 |
| polymicrobial bacteremia associated with lipid emulsion in a neonatal intensive care unit. | polymicrobial bacteremia developed in 5 of 20 infants in a neonatal intensive care unit during a 48-hour period; 2 infants died. klebsiella pneumoniae serotypes 21 and 24 and enterobacter cloacae were isolated from four infants, and k. pneumoniae serotype 24 and e. cloacae were isolated from the other infant. case-control studies revealed an association between receipt of lipid emulsion on one day and the subsequent development of bacteremia (p = 0.0005). epidemiologic evidence suggested that ex ... | 1983 | 6408618 |
| is15, a new insertion sequence widely spread in r plasmids of gram-negative bacteria. | we have shown that the is15 element, first detected in salmonella ordonez and previously designated is1522 (labigne-roussel et al. 1981), could transpose, with an approximate frequency of 5 x 10(-5), to various sites of different replicons in an escherichia coli host deficient for general homologous recombination. physical mapping with restriction endonucleases of this 1,500 base pairs (bp) transposable module indicated the presence of two, possibly contiguous, directly repeated internal sequenc ... | 1983 | 6304459 |
| n-(functionalized alkyl) derivatives of 6-aminopenicillanic acid: a new series of specific inhibitors of beta-lactamase from enterobacter cloacae p99. | eight of nine new n-alkylaminopenicillanic acids (7a approximately c, e approximately j), prepared via efficient direct monoalkylation reactions, were found to be specific inhibitors of cephalosporinase p99 with ic50 less than or equal to 4 mg/liter, while representative corresponding s-oxidized derivatives were less active. | 1983 | 6317623 |
| phenomenon of resistance to augmentin associated with sensitivity to ampicillin: occurrence and explanation. | ampicillin was found to be some tenfold more active than amoxycillin against enterobacter cloacae. this finding explains the observation that some ent cloacae strains are sensitive to ampicillin in the disc test but resistant to augmentin. ampicillin was also found to be more active than amoxycillin against citrobacter freundii and serratia marcescens. in view of these findings, the practice of using ampicillin discs to predict sensitivity to amoxycillin should be reconsidered. the use of both a ... | 1983 | 6343436 |
| chromosomal beta-lactamases of enterobacter cloacae are responsible for resistance to third-generation cephalosporins. | about 70% of all enterobacter cloacae strains tested possessed one of two species-specific beta-lactamases. these enzymes, e. cloacae beta-lactamase a and e. cloacae beta-lactamase b, with isoelectric points of 8.8 and 7.8, respectively, had the same ph and temperature optima. both showed similar enzyme kinetics and were inhibited by cloxacillin but not by p-chloromercuribenzoate. e. cloacae beta-lactamase b appeared to be identical with the enzyme of e. cloacae p99. by a mutation in a regulator ... | 1983 | 6351733 |
| efficacy of brl 25000 against serratia marcescens, enterobacter cloacae, and citrobacter freundii in urinary tract infections. | synergism between amoxicillin and clavulanic acid was not expected against cephalosporinase-producing bacterial strains because clavulanic acid has little inhibitory action on cephalosporinases. however, in a clinical trial of brl 25000 (amoxicillin-clavulanic acid), excellent results were obtained in complicated urinary tract infections caused by serratia marcescens, enterobacter cloacae, and citrobacter freundii strains which produced cephalosporinase and were highly resistant to amoxicillin a ... | 1983 | 6357078 |
| [characteristics of the substrate specificity of the crude endogenous beta-lactamases of gram-negative bacteria]. | fifty clinical strains of gram-negative bacteria highly resistant to beta-lactam antibiotics were studied and 9 strains producing beta-lactamases were selected. from these cultures crude beta-lactamases were isolated. the substrate specificity of these crude preparations and their sensitivity to the inhibitory effect of dicloxacillin, methicillin and carbenicillin were studied with the spectrophotometric and hydroxylamine methods. the results of the study obtained with the 2 methods were in the ... | 1983 | 6416154 |
| induction of cephalosporinase production by various penicillins in enterobacteriaceae. | the inducer activity of seven penicillins for cephalosporinase (csase) production and their antibacterial activity against csase-producing strains were studied using clinical isolates of proteus morganii, p. rettgeri, p. vulgaris, enterobacter cloacae, and serratia marcescens. piperacillin, apalcillin, and methicillin showed rather low inducer activity for csase production in all strains tested. on the other hand, ampicillin, carbenicillin, and sulbenicillin showed high inducer activity for csas ... | 1983 | 6358172 |
| influence of methoxy-substitution of beta-lactam compounds on the interaction with various beta-lactamases. | the interaction of 6 alpha-(temocillin) and 7 alpha-methoxy substituted (cefoxitin) beta-lactam compounds with various beta-lactamases was studied employing enzyme kinetics and compared to that of unsubstituted compounds. both chromosomally mediated enzymes from enterobacter cloacae and citrobacter freundii were competitively inhibited by the methoxy-substituted compounds. higher concentrations of cefoxitin caused a competitive inhibition of the plasmid-mediated tem-1 enzyme, whereas temocillin ... | 1983 | 6362278 |
| investigations on beta-lactamase stability of recently developed beta-lactam compounds: study of enzyme kinetics. | the plasmid-mediated tem-1 enzyme (e. coli k12 r6k) and chromosomally mediated enzymes from enterobacter cloacae (iep 8.5) and citrobacter freundii (iep 9.5) were highly purified. enzyme kinetics were studied with various therapeutic compounds as substrates and lamoxactam, azthreonam, and n-formimidoyl thienamycin as inhibitors. lamoxactam and azthreonam failed to inhibit the tem-1 enzyme, whereas n-formimidoyl thienamycin was a competitive inhibitor. ki was 5 mumol/l--thus corresponding to km-- ... | 1983 | 6372325 |
| effect of nifa product on suppression of nif- phenotype of gln mutation and constitutive synthesis of nitrogenase in klebsiella pneumoniae. | this paper describes the role of nifa product on the ammonia regulation of nitrogen fixation in k. pneumoniae. a plasmid carrying nifa gene under the promoter of tetracycline resistance gene was constructed. when this nifa carrying plasmid was introduced into a glnag mutant, the nif- phenotype of this gln mutant was suppressed. furthermore, when the plasmid was introduced into the wild type and glnag mutant, derepression of nitrogenase synthesis in ammonia occurred in both strains and the produc ... | 1983 | 6143398 |
| in vitro activity of moxalactam against pathogenic bacteria and its comparison with other antibiotics. | 843 isolates from clinical specimens were tested against moxalactam by disc agar diffusion. the bacteria used in this study consisted of escherichia coli, enterobacter aerogenes, enterobacter agglomerans, enterobacter cloacae, klebsiella pneumoniae, proteus mirabilis, providencia rettgeri, pseudomonas aeruginosa, serratia marcescens, staphylococcus aureus, staphylococcus epidermidis and group b and group d streptococci. in vitro activity of moxalactam was compared with the following antibiotics: ... | 1983 | 6219865 |
| antibiotic penetration in abdominal infection: a case of tobramycin failure responsive to moxalactam. | a 50-year-old male developed an enterobacter cloacae abdominal infection as the result of gangrene of a gastric remnant after gastrectomy. aggressive antibiotic treatment with tobramycin and clindamycin was instituted, but despite documented in vitro bacterial sensitivity and high serum tobramycin levels, the patient's clinical condition worsened. enterobacter cloacae continued to grow in the abdominal drainage cultures. as a last resort, moxalactam therapy was started. within 36 hours, dramatic ... | 1983 | 6220879 |
| norfloxacin versus cotrimoxazole in the treatment of lower urinary tract infections. | in a randomised prospective study 61 patients with lower urinary tract infection received either 200 mg norfloxacin (33 patients) or 480 mg cotrimoxazole (28 patients) twice daily for ten days. pathogens included escherichia coli in 48 patients, proteus mirabilis in ten patients, and enterobacter cloacae, klebsiella pneumoniae, citrobacter freundii and staphylococcus saprophyticus in one patient each. the mics of norfloxacin and cotrimoxazole were less than or equal to 0.03 mg/l and less than or ... | 1983 | 6224685 |
| open study of ceftazidime in serious infections due to multiply-resistant bacteria. | we treated 37 infections in 32 patients who had one or more significant underlying diseases. most of the responsible micro-organisms were multiresistant, but were initially sensitive to ceftazidime. they included 16 pseudomonas spp., 10 serratia spp., 6 klebsiella spp., 7 other enterobacteriaceae, 3 staphylococcus spp., 3 strict anaerobes and 1 acinetobacter anitratus. indications for ceftazidime encompassed a broad spectrum of diseases: 10 complicated uti, 13 skeletal and soft tissue infections ... | 1983 | 6352619 |
| nif-hybrids of enterobacter: selection for nif gene integration with chlorate. | the nif gene group from klebsiella can be transferred into enterobacter cloacae by conjugation using escherichia coli donor cells carrying the composite self-transmissible nif-plasmid prd1. a small fraction of the hybrids obtained is stable upon prolonged passaging without selection. their stability is due to integration of prd1 into the chromosome. such integration hybrids were chlorate resistant, and nitrate reductase negative, which indicated that integration preferentially occurred within on ... | 1983 | 6353161 |
| ceftazidime in patients with pseudomonas infections. | ceftazidime was administered to 41 patients with serious infections caused by pseudomonas aeruginosa (24 cases) and other bacteria (17 cases). the clinical response rate of pseudomonas infections (88%) was similar to that of other bacteria (94%) with microbiological eradication of 83% of initial pseudomonas isolates compared to 82% of non-pseudomonas strains. the development of resistance to ceftazidime during therapy was observed in 3 cases (enterobacter agglomerans, enterobacter cloacae, and p ... | 1983 | 6225762 |
| facultative gram-negative enteric rods in persistent periapical infections. | a bacteriological investigation has been made in two cases of persistent periapical infections. neither of the two infections responded to root canal therapy including penicillin or penicillin and erythromycin. samples were taken aseptically for bacteriological examination through and root canals. chloroform-washed, sterile paper points were used for sampling. cultivation was performed immediately at chairside on kanamycin-vancomycin laked blood agar (kvlb) and blood agar supplemented with menad ... | 1983 | 6346780 |
| transferable antibiotic resistance in a general hospital: a two year survey. | for two years transferable antibiotic resistance (tar) was studied by replicator methods in strains of enterobacteriaceae isolated in a 900-bed hospital. transfer to an escherichia coli recipient was demonstrated in 21% of 7,800 enterobacteriaceae. it was most common in klebsiella (37% of isolates) and least in acinetobacter (6%). the mean number of phenotypic resistance markers (rms) transferred was higher from klebsiella pneumoniae or enterobacter cloacae than from e. coli or p. mirabilis. k. ... | 1983 | 6349599 |
| synthesis of plasmid-coded heat-labile enterotoxin in wild-type and hypertoxinogenic strains of escherichia coli and in other genera of enterobacteriaceae. | the effect of host determinants on expression of plasmid-coded heat-labile enterotoxin (lt) was examined. a collection of lt plasmids was introduced into isogenic strains of escherichia coli k-12 strains containing the wild type or hypertoxinogenic (htx-2) allele. for each plasmid tested, production of lt increased by approximately 1.5- to 3-fold in the host containing htx-2, indicating that the htx-2 allele affects a regulatory function for lt production that is common to many different enterot ... | 1983 | 6350177 |
| evaluation of the updated ms-2 bacterial identification system in comparison with the api 20e system. | the recently updated ms-2 bacterial identification system software (abbott laboratories, diagnostic division, irving, tex.) was compared with the original ms-2 bacterial identification software and the api 20e, using 968 strains of enterobacteriaceae. the updated ms-2 software correctly identified 94.4% of the isolates tested. api 20e and the original ms-2 software correctly identified 91 and 85.3% of the strains, respectively. ms-2 responses were considered to be equivocal (needing additional t ... | 1983 | 6350342 |
| [microbiological studies with the new penicillin brl 17421 (temocillin)]. | in vitro evaluation of brl 17421 (temocillin), a new penicillin. the in vitro antibacterial activity of brl 17421 (temocillin), a new penicillin, was determined in quantitative serial broth dilution tests and was compared to that of mezlocillin, piperacillin, cefazolin and cefotaxime against 751 clinical isolates of the enterobacteriaceae family. in addition, the sensitivity of 211 mezlocillin-resistant gram-negative rods to brl 17421 was also determined. temocillin exhibited a high level of ant ... | 1983 | 6302007 |
| in vitro activity and beta-lactamase stability of cefodizime, an aminothiazolyl iminomethoxy cephalosporin. | cefodizime, an iminomethoxy aminothiazolyl cephalosporin similar to moxalactam and ceftazidime, was less active (minimal inhibitory concentration, 1.6 to 12 micrograms) than cefazolin or cefotaxime against staphylococcus aureus and staphylococcus epidermidis. it inhibited haemophilus and neisseria spp. at less than 0.5 microgram/ml. it did not inhibit methicillin-resistant staphylococci, enterococci, or listeria spp. and was 8- to 32-fold less active than cefotaxime, moxalactam, or ceftazidime a ... | 1983 | 6311090 |
| [in vivo effects of cefoperazone in local infection]. | the in vivo antibacterial activity and the penetration into inflammatory tissues of cefoperazone (cpz) were compared with those of cefotiam (ctm) in local infection systems using mouse subcutaneous abscess and rat granuloma pouch. the serum levels of cpz in subcutaneous abscess in mice caused by staphylococcus aureus f-230 (penicillinase producing strain) were lower than that of ctm, but there was no significance between the therapeutic effects of both drugs. the same results were obtained using ... | 1983 | 6325755 |
| budd-chiari syndrome recurring in a transplanted liver. | a patient with budd-chiari syndrome who underwent orthotopic liver transplantation and developed recurrent disease is described. the immediate postoperative period was complicated by multiple thrombotic episodes, followed by a period of apparent remission associated with the initiation of coumadin and persantine therapy. after discontinuation of such antithrombotic therapy in order to biopsy the liver, the patient experienced another series of clinically overt vascular thromboses and ultimately ... | 1983 | 6337073 |
| surface attachment of a sediment isolate ofenterobacter cloacae. | enterobacter cloacae was recovered from surface sediments of a flood control channel in an area where freshwater runoff mixed with coastal seawater. cells of this bacterium elaborated an extensive capsule when cultured under laboratory conditions designed to promote extracellular polysaccharide production. colonization of glass surfaces by cells was similar under aerobic and anaerobic conditions. temperature exerted little effect on maximum adherent cell density in the range of 15-25°c. the avai ... | 1983 | 24221819 |
| comparative in vitro activity and beta-lactamase stability of fr 17027, a new orally active cephalosporin. | fr 17027, a new orally absorbed cephalosporin ester, inhibited group a and b streptococci and streptococcus pneumoniae at less than or equal to 0.1 micrograms/ml, which is similar to the inhibition concentration of amoxicillin and cefaclor, and was more active than cephalexin. it was less active (mic, 25 micrograms/ml) against staphylococci than was cephalexin, and it did not inhibit streptococcus faecalis or listeria monocytogenes. fr 17027 inhibited beta-lactamase-producing isolates of neisser ... | 1984 | 6333207 |
| susceptibility of gram-negative bacteria to polymyxin b nonapeptide. | subinhibitory concentrations of polymyxin b nonapeptide sensitized all 21 polymyxin-susceptible gram-negative bacterial strains studied to hydrophobic antibiotics such as fusidic acid, novobiocin, and erythromycin. the susceptibility increases were usually 30- to 300-fold. the strains included representatives of escherichia coli with different o- and k-antigens, klebsiella pneumoniae, klebsiella oxytoca, enterobacter cloacae, enterobacter agglomerans, salmonella typhimurium, acinetobacter calcoa ... | 1984 | 6331296 |
| synergism of ps-5 with penicillins and cephalosporins in antimicrobial activity against beta-lactam-resistant gram-negative microorganisms. | the in vitro synergism of ps-5 combined with various penicillins and cephalosporins in antimicrobial activity was examined in detail against beta-lactam-resistant gram-negative bacteria. ps-5 showed a highly significant synergism in antimicrobial action against escherichia coli rgn238 in combination with penicillins; and against proteus vulgaris gn76 and serratia marcescens t55 in combination with cephalosporins. it was moderately synergistic against citrobacter freundii gn346, enterobacter cloa ... | 1984 | 6334679 |
| interaction of ro 17-2301 (ama-1080) with beta-lactamases. | against a variety of beta-lactamases tested, mostly of chromosomal origin, ro 17-2301 (ama-1080) proved to be more stable than the new cephalosporins and thus resembles aztreonam. against the beta-lactamases from klebsiella oxytoca and pseudomonas vulgaris, however, ro 17-2301 proved to be much more stable than aztreonam. enzymatic hydrolysis, performed with the k. oxytoca beta-lactamase, yielded a single compound, viz. the microbiologically inactive, ring-opened structure. ro 17-2301 is a poten ... | 1984 | 6335074 |
| cefmenoxime therapy in bacterial osteomyelitis. | cefmenoxime, a new parenteral beta-lactamase-resistant cephalosporin, was evaluated for safety and efficacy in 15 patients (10 male and five female) with acute (1 patient) and chronic (14 patients) osteomyelitis. diagnosis was made by culture of the surgical biopsy specimen. osteomyelitis was treated with 8 to 12 g of cefmenoxime per day (mean 9.1 g) for 42 to 66 days (mean 47.3). staphylococcus aureus was the most frequently isolated organism. minimum inhibitory concentrations (mics) of cefmeno ... | 1984 | 6097118 |
| [clinical and pharmacokinetic study of ceftriaxone in pediatric bacterial infections]. | ceftriaxone (ro 13-9904, ctrx) was evaluated for its safety and efficacy in 33 children with various bacterial infections including 10 cases of bacterial meningitis. ctrx was effective in all but 1 case who had acute mucositis due to a resistant strain of enterobacter cloacae. the serum half-life (t1/2 beta) was 4.5 +/- 1.6 hours after an intravenous bolus injection in children. cerebrospinal fluid levels of ctrx in the acute phase of bacterial meningitis were 7.69 +/- 4.75 mcg/ml. the only side ... | 1984 | 6098701 |
| characterization of two clinical, multiple-drug-resistant isolates of enterobacter cloacae. | two multiple drug resistant enterobacter cloacae isolates (nos. 460 and 493) varied phenotypically in bacteriocin susceptibility in the absence of significant o antigen variation. both isolates were susceptible to chloramphenicol, nitrofurantoin, polymyxin b, nalidixic acid, norfloxacin, and enoxacin only. one isolate carried a non-conjugative resistance (r) plasmid, whereas the other isolate contained a conjugative, 'curable' r plasmid and a cryptic plasmid. both wild-type isolates constitutive ... | 1984 | 6207994 |
| in vitro activity of pefloxacin compared to that of quinolones and other antimicrobial agents. | pefloxacin is a new methyl-4-piperazinyl quinolone. it had mic90 values of less than 0.01 to 0.8 micrograms/ml for the majority of escherichia coli, klebsiella, oxytoca, citrobacter, providencia, enterobacter cloacae, enterobacter aerogenes, morganella and proteus mirabilis. it inhibited ampicillin, cephalexin and nalidixic acid resistant isolates of these species. against pseudomonas the pefloxacin mic90 was 3.1 micrograms/ml. staphylococcus aureus had a mic50 of 0.4 micrograms/ml and a mic90 o ... | 1984 | 6241847 |
| carbohydrate-binding sites of the mannose-specific fimbrial lectins of enterobacteria. | the combining sites of type 1 fimbrial lectins of various species of enterobacteria were studied by measuring the inhibitory activity of linear and branched oligosaccharides and several glycosides of d-mannose on the agglutination of yeast cells by the organisms. the results showed that all five strains of escherichia coli tested possessed an elongated combining site best fitting a trisaccharide and including a hydrophobic region. similar results were obtained with klebsiella pneumoniae. within ... | 1984 | 6142000 |
| selection of multiple antibiotic resistance by quinolones, beta-lactams, and aminoglycosides with special reference to cross-resistance between unrelated drug classes. | the ability of three quinolones, two beta-lactams, and one aminoglycoside to select resistant mutants was examined in tests with 30 isolates of commonly encountered nosocomial pathogens. ciprofloxacin and norfloxacin, two new quinolone derivatives, were no more likely to select resistant mutants than amikacin, whereas nalidixic acid, an older quinolone derivative, was the most likely of the six drugs examined to select resistant mutants. mutational frequencies of 10(-7) to 10(-8) were observed i ... | 1984 | 6098219 |
| [use of cefotaxime in severe infections in newborn infants]. | twenty-seven septicemia, 2 urinary tract infections and 2 meningitis were treated with cefotaxime. the pathogenic organisms were most often entero-bacteria (16 e. coli, 2 klebsiella, 2 enterobacter cloacae, 1 proteus, 1 acinetobacter); sometimes they were streptococcus (5 streptococcus d, 3 streptococcus b, 1 streptococcus salivarius). cefotaxime was given alone to 16 patients, in association to an aminoglycoside in 15 cases. it was administered by infusion over 30 minutes every 8 hours in a dai ... | 1984 | 6096793 |
| enterobacter sakazakii: a tween 80 esterase-positive representative of the genus enterobacter isolated from powdered milk specimens. | enterobacter sakazakii is the new species name introduced in 1977 for yellow-pigmented strains originally designated as yellow enterobacter cloacae. all of the six e.sakazakii strains isolated from powdered milk specimens were found to produce tween 80 esterase after 7 days of incubation at 25 degrees c and 37 degrees c. from e.cloacae it is distinguishable by reactions in four, or even three, biochemical tests, i.e. by production of yellow pigment, positive production of tween 80 esterase and b ... | 1984 | 6527001 |
| beta-lactamase production in enterobacter cloacae and citrobacter freundii. | the beta-lactamase activity with ampicillin (a) and cephalothin (ce) as substrate was examined in 28 strains of ent. cloacae and 24 strains of c. freundii by a micro-iodometric-(mia) and an ultraviolet assay (uva). carbenicillin resistance (ca-r) was present in 32 strains (16 of each species). all ca-resistant (ca-r) strains had elevated amounts of beta-lactamase. the conditions were very similar in the two species. the ca-r strains could be divided into two subgroups. one group had very high am ... | 1984 | 6335817 |
| [induction of beta-lactamases in enterobacter cloacae with beta-lactam antibiotics]. | the induction potency of various beta-lactam compounds was studied in a clinical isolate which exhibited resistance against most beta-lactam compounds; however, spontaneous beta-lactamase production was only marginal in this strain. in general, all beta-lactam derivatives included in this study possessed induction potency independent of the nucleus of the compound. n-formimidoyl thienamycin, the penem compound sch 29482, 6-aminopenicillanic acid, and clavulanic acid proved to be the most potent ... | 1984 | 6335880 |
| [isolation of propionibacterium acnes and enterobacter cloacae from a case of infective endocarditis]. | 1984 | 6431026 | |
| effect of ph, application technique, and chlorine-to-nitrogen ratio on disinfectant activity of inorganic chloramines with pure culture bacteria. | the influence of ph, application technique, and chlorine-to-nitrogen weight ratio on the bactericidal activity of inorganic chloramine compounds was determined with stock and environmental strains of escherichia coli, salmonella spp., pseudomonas aeruginosa, klebsiella pneumoniae, and enterobacter cloacae. the rate of inactivation increased from 1.5 to 2 times as the chlorine-to-nitrogen weight ratio was adjusted from 2:1 to 5:1, 5 to 6 times as the ph was decreased from 8 to 6, and 5 to 6 times ... | 1984 | 6437328 |
| [dibekacin in the treatment of urinary infections in the elderly]. | urinary tract infections in the elderly are severe and intractable, often justifying the use of aminoglycosides. we studied the effects of dibekacin in 28 patients, with no vesical catheter, whose average age was 78 +/- 6.1 years. the drug was given for ten days, in an average dose of 2.1 mg/kg/day divided into two injections. serum concentration was measured after one hour on day 1 and after eight hours on days 1 and 10. causative pathogens, all susceptible to dibekacin, were: 18 e. coli, 3 pro ... | 1984 | 6462747 |