Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| comparative efficacies of erythromycin-sulfisoxazole and cefaclor in acute otitis media: a double blind randomized trial. | a prospective double blind trial compared the fixed combination of erythromycin-sulfisoxazole (e/s) with cefaclor in the treatment of acute otitis media. one hundred nineteen children in six centers across canada were studied. diagnostic tympanocentesis of 134 ears yielded 135 bacterial isolates: streptococcus pneumoniae (42%); haemophilus influenzae (21%); branhamella catarrhalis (10%); streptococcus pyogenes (5%); and other bacteria (22%). seventy-seven percent of strains of b. catarrhalis and ... | 1987 | 3302918 |
| meningitis due to branhamella catarrhalis. | we report a case of branhamella catarrhalis meningitis which was unusual in that the patient was a healthy immunocompetent adult, the onset was subacute, and the cerebrospinal fluid pleocytosis was predominantly lymphocytic. following treatment with intravenous penicillin, recovery was complete apart from residual cortical dysarthria. | 1987 | 3304249 |
| enzymatic modification of aminoglycoside antibiotics by branhamella catarrhalis carrying an r factor. | fifteen out of 89 clinical strains of branhamella catarrhalis isolated from patients at the university hospital of zaragoza were resistant to aminoglycosides and other antimicrobials. in two strains, b. catarrhalis 220 and b. catarrhalis 115, the resistance to aminoglycosides was associated with synthesis of aminoglycoside-modifying enzymes, namely 3"-o-phosphotransferase [aph(3")] and 3'-o-phosphotransferase [aph(3')]. b. catarrhalis 115 was resistant to ampicillin, streptomycin, kanamycin, neo ... | 1987 | 3304917 |
| cefuroxime axetil in acute purulent exacerbations of chronic bronchitis. | 51 hospitalised patients with acute purulent exacerbations of chronic bronchitis were treated for ten days with two daily 1 g doses of the orally absorbed pro-drug cefuroxime axetil. however, some patients were still infected with haemophilus influenzae or branhamella catarrhalis at follow-up, and sputum purulence remained. clinical results were "excellent" or "good" in 60% of the evaluable patients one week after the end of the treatment. mean peak serum concentrations averaged 12.8 mg/l with m ... | 1987 | 3312021 |
| randomized, open label, multicenter trial of cefixime compared with amoxicillin for treatment of acute otitis media with effusion. | cefixime, a new third generation cephalosporin antibiotic for oral use, was evaluated for safety and efficacy in the treatment of children with acute otitis media with effusion. fifteen united states clinical investigators participated in the multicenter clinical trial. one hundred twenty children were randomly assigned to a 10-day course of either cefixime, 8 mg/kg, given daily (qd) (60 patients) or amoxicillin, 40 mg/kg/day, administered in three divided doses (60 patients). tympanocentesis wa ... | 1987 | 3320928 |
| antimicrobial activity of ly164846, a new oral cephalosporin, and recommendations for disk diffusion tests. | ly164846 is a new oral cephalosporin with a limited spectrum of antimicrobial activity that includes staphylococci (other than methicillin-resistant), streptococci (other than enterococci), haemophilus influenzae (beta-lactamase-negative and beta-lactamase-positive), branhamella catarrhalis (beta-lactamase-negative and beta-lactamase-positive), and neisseria species (beta-lactamase negative and beta-lactamase-positive). the tentative recommendations for susceptibility breakpoints are less than o ... | 1987 | 3100126 |
| api quadferm+ with rapid dnase for identification of neisseria spp. and branhamella catarrhalis. | the quadferm+ system (analytab products, plainview, n.y.), a 2-h carbohydrate degradation method for the identification of neisseria spp., was evaluated along with a rapid dnase test for confirmation of branhamella catarrhalis. quadferm+ identified 100% of 82 n. gonorrhoeae and 96% of 54 n. meningitidis strains. the two misidentified meningococcal strains were biochemically atypical and were also misidentified by the conventional method. of 26 n. lactamica strains, 25 (96%) were correctly identi ... | 1987 | 3102550 |
| bmy 28100, a new oral cephalosporin. | bmy 28100, a new oral cephalosporin with a (z)-propenyl side chain at the 3 position and a p-hydroxyphenylglycyl substituent at the 7 position, was evaluated in comparison with cefaclor and cephalexin and, when appropriate, ampicillin and vancomycin. in vitro, bmy 28100 was more active than the reference cephalosporins against streptococci, staphylococcus aureus, staphylococcus epidermidis, listeria monocytogenes, haemophilus influenzae, propionibacterium acnes, clostridium perfringens, and clos ... | 1987 | 3105449 |
| in vitro activity of ro 23-6240 (am-833): a new fluoroquinolone. | the in vitro activities of ro 23-6240 (am-833) and four comparative fluoroquinolones were studied. minimal inhibitory concentrations (mics) of ro 23-6240, which inhibited at least 90% of strains, were less than or equal to 0.03-1 microgram/ml for staphylococcus aureus, staphylococcus epidermidis, enterobacteriaceae, acinetobacter anitratus aeromonas hydrophila, branhamella catarrhalis, and haemophilus influenzae, 2-8 micrograms/ml for staphylococcus saprophyticus, streptococci, diphtheroids, and ... | 1987 | 3107872 |
| etiology and diagnosis of neonatal conjunctivitis. | chlamydia trachomatis was isolated from the most inflamed eye of 13 of 107 (12%) infants with neonatal purulent conjunctivitis and from none of 100 healthy infants (p less than 0.01). staphylococcus aureus was recovered from 49 (46%) inflamed eyes and from 8 (8%) healthy eyes (p less than 0.01). streptococcus pneumoniae, haemophilus influenzae, branhamella catarrhalis, escherichia coli and klebsiella pneumoniae were isolated from very few infants with conjunctivitis but not from controls. no org ... | 1987 | 3109205 |
| supplement peptone agar--a simple carbohydrate degradation plate medium for the identification of neisseria species. | a carbohydrate degradation medium was developed for the detection of acid production by neisseria species and branhamella catarrhalis. a total of 223 clinical isolates were identified by supplemented peptone agar and the results were compared with those of cystine trypticase agar. supplemented peptone agar and cystine trypticase agar correctly identified 99.1% and 93.7% of the total strains respectively within 24 h. with cystine trypticase agar method another 4% of the isolates could be identifi ... | 1987 | 3115001 |
| the influence of culture medium on the comparative in-vitro activity of amoxycillin and amoxycillin/clavulanic acid against branhamella catarrhalis. | 1987 | 3117763 | |
| optimal dilution susceptibility testing conditions, recommendations for mic interpretation, and quality control guidelines for the ampicillin-sulbactam combination. | the ampicillin-sulbactam combination was evaluated in vitro to determine the optimal susceptibility testing conditions among five combination ratios and four fixed concentrations of sulbactam. the organisms tested were markedly resistant to aminopenicillins and most other beta-lactams. the ratio of 2:1 is recommended to assure recognition of the ampicillin-sulbactam spectrum and minimize false-susceptible results among strains known to be resistant to this combination. proposed mic breakpoint co ... | 1987 | 3117843 |
| respiratory tract infections due to branhamella catarrhalis: epidemiological data from western australia. | during a 3-year period branhamella catarrhalis was isolated in significant numbers from 239 (1.3%) of 19,488 specimens of sputum sent for routine microbiological examination at a 700-bed general hospital. the majority of patients (83%) were over 60 years of age and 65% were male. there was a distinct seasonal variation in isolations with a peak incidence during the winter and early spring, a pattern not found with other pathogens. susceptibility to amoxycillin decreased by approximately 50% over ... | 1987 | 3119360 |
| correlation between branhamella catarrhalis adherence to oropharyngeal cells and seasonal incidence of lower respiratory tract infections. | bacterial colonization of the oropharynx is the initial event in most lower respiratory tract infections. to study the role of bacterial adherence in lower respiratory tract infections caused by branhamella catarrhalis (b. catarrhalis) in winter, in vitro adherence assays of the organism to human oropharyngeal cells were carried out in winter, spring, summer and autumn. a total of 57 adults of both sexes were studied from january to december 1985. forty eight persons of 57 had chronic pulmonary ... | 1987 | 3120353 |
| recovery of beta-lactamase producing bacteria in pediatric infections. | the presence of beta-lactamase producing bacteria (beta lpb) was investigated in specimens obtained from 1469 children who presented with infections of the skin and soft tissue (648), upper respiratory tract (514), pulmonary sites (137), surgical sites (113), and other (57). of 4989 bacterial isolates recovered, 910 (18%) were beta lpb, 492 (54%) aerobes, and 418 (46%) anaerobes. the beta lpb were recovered in 751 (51%) of the children. the most frequently recovered beta lpb was staphylococcus a ... | 1987 | 3121158 |
| ro 23-6240 (am-833), a new fluoroquinolone: in vitro antimicrobial activity and tentative disk diffusion interpretive criteria. | the susceptibility of over 7000 recent clinical bacterial isolates to ro 23-6240, a new trifluorinated quinolone, was determined at four medical centers. over 99% of enterobacteriaceae and 97% of staphylococci were inhibited by less than or equal to 2.0 micrograms/ml of ro 23-6240. only 71% of pseudomonas spp. were inhibited by this concentration. streptococci and enterococci were resistant to ro 23-6240. clinical isolates of haemophilus spp., pathogenic neisseria spp., and branhamella catarrhal ... | 1987 | 3121241 |
| rapid identification of pathogenic neisseria species and branhamella catarrhalis. | two systems, the identicult-neisseria (idn; scott laboratories, inc., fiskeville, r.i.) strip and the neisseria/haemophilus identification test kit (nhi; vitek systems, inc., hazelwood, mo.) card, were compared with the 4-h minitek system (bbl microbiology systems, cockeysville, md.) for their ability to rapidly identify 157 pathogenic neisseria and branhamella catarrhalis isolates. idn, limited in its identification to four species, when incubated at 35 degrees c for 10 min identified 99% of th ... | 1987 | 3121668 |
| [susceptibility of bacteria isolated from the patients with lower respiratory tract infections to antibiotics (1985)]. | it has been more than 4 years since third-generation cephems were introduced into clinical practice. the range of our drug selection definitely tends to increase, because we today have more antibiotics with wider spectrum, antibiotics with strong activities only against gram-negative strains, such as monobactams, and those with tremendously high activities such as quinolone carboxylic acid derivatives, in comparison to those we had in the past. among isolates obtained mainly from sputa of 567 pa ... | 1987 | 3121887 |
| branhamella catarrhalis as a cause of bacterial tracheitis. | 1987 | 3122157 | |
| branhamella catarrhalis and streptococcus pneumoniae type 9 causing recurrent coalescent mastoiditis. | 1987 | 3122159 | |
| branhamella catarrhalis respiratory infections. | branhamella catarrhalis, a normal commensal of the oropharynx, is increasingly recognized as an important cause of bronchitis and bacterial pneumonia. six patients with b. catarrhalis pneumonia documented by transtracheal aspirate or blood culture were studied, and 429 previously reported cases of b. catarrhalis bronchitis and pneumonia were reviewed. the mean age of patients with b. catarrhalis infection was 64.8 years, and preexisting chronic obstructive pulmonary disease was common. the typic ... | 1987 | 3122301 |
| branhamella catarrhalis: beta-lactamase production and sensitivity to oral antibiotics, including new cephalosporins. | 1987 | 3123451 | |
| disk diffusion susceptibility testing of branhamella catarrhalis with ampicillin and seven other antimicrobial agents. | a total of 74 clinical isolates of branhamella catarrhalis were characterized with respect to their ampicillin, amoxicillin-clavulanate, cephalothin, cefaclor, erythromycin, tetracycline, chloramphenicol, and trimethoprim-sulfamethoxazole mics and zones of inhibition. disk diffusion tests were performed according to the guidelines of the national committee for clinical laboratory standards with two different media (mueller-hinton agar and chocolate mueller-hinton agar) and plates incubated under ... | 1987 | 3124732 |
| branhamella catarrhalis as a possible skin pathogen. | 1987 | 3128412 | |
| [acute laryngobronchitis by moraxella subgenus branhamella catarrhalis (infantile case report)]. | 1987 | 3130436 | |
| analysis of cell division gene ftsz (sulb) from gram-negative and gram-positive bacteria. | the ftsz (sulb) gene of escherichia coli codes for a 40,000-dalton protein that carries out a key step in the cell division pathway. the presence of an ftsz gene protein in other bacterial species was examined by a combination of southern blot and western blot analyses. southern blot analysis of genomic restriction digests revealed that many bacteria, including species from six members of the family enterobacteriaceae and from pseudomonas aeruginosa and agrobacterium tumefaciens, contained seque ... | 1987 | 2432055 |
| aetiology of community-acquired pneumonia in hospital treated patients. | from may 1982 a prospective 1-year study of adult patients with community-acquired, radiologically verified, hospital treated pneumonia was performed at the department of infectious diseases, orebro medical center hospital, orebro, sweden. the study included 147 patients with a median age of 71 years. special efforts to diagnose a pneumococcal aetiology were accomplished by antigen detection of the pneumococcal c-polysaccharide (pnc) in sputum and saliva samples and by serological methods for de ... | 1987 | 2447637 |
| spectrum and mode of action of azithromycin (cp-62,993), a new 15-membered-ring macrolide with improved potency against gram-negative organisms. | the macrolide antibiotic azithromycin (cp-62,993; 9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin a; also designated xz-450 [pliva pharmaceuticals, zagreb, yugoslavia]) showed a significant improvement in potency against gram-negative organisms compared with erythromycin while retaining the classic erythromycin spectrum. it was up to four times more potent than erythromycin against haemophilus influenzae and neisseria gonorrhoeae and twofold more potent against branhamella catarrhalis, campylobacte ... | 1987 | 2449865 |
| branhamella catarrhalis activates human b lymphocytes following interactions with surface igd and class i major histocompatibility complex antigens. | branhamella catarrhalis initiated dna synthesis in human blood or spleen cells enriched for b lymphocytes but did not activate t-lymphocyte-enriched fractions. monoclonal antibodies were used to determine which b-cell surface molecules were of importance for the activation signal. the addition of monoclonal antibodies reactive with igd, hla class i antigens, and b2-microglobulin to b lymphocyte cultures selectively inhibited the b-lymphocyte response to b. catarrhalis. antibody binding to igd an ... | 1988 | 2449982 |
| histamine release from human pulmonary mast cells induced by bacterial antigens. | antigens of four bacteria (staphylococcus aureus, haemophilus influenzae, streptococcus viridans, branhamella catarrhalis) were tested for their ability to release histamine from human pulmonary mast cells recovered by means of bronchoalveolar lavages. for the sake of comparison the action of bacterial antigens on human mesenteric and adenoidal mast cells obtained by enzymatic dispersion of the tissues was studied. bal mast cells released histamine in response to all studied bacterial antigens. ... | 1988 | 2468267 |
| the envelope structure of branhamella catarrhalis as studied by transmission electron microscopy. | the envelope structure of branhamella catarrhalis was studied by electron microscopy and compared with that of other bacteria of the family neisseriaceae, such as moraxella lacunata subsp. liquefaciens and neisseria gonorrhoeae. negative staining of b. catarrhalis showed a mamilliform surface similar to that of moraxella. on thin sections, the cell wall appeared to be made up of a wavy outer membrane tightly linked to a straight peptidoglycan layer. spicule-like structures protruded from the cel ... | 1988 | 2472827 |
| comparison of the microbiology of group a and non-group a streptococcal tonsillitis. | we studied the microbial flora of tonsils removed from 20 children who suffered from recurrent group a beta-hemolytic streptococcal (gabhs) tonsillitis and 20 who had tonsillar hypertrophy following recurrent non-gabhs tonsillitis. similar polymicrobial aerobic and anaerobic flora were recovered from the cores of the tonsils in each group. beta-lactamase-producing bacteria (blpb) were recovered more often in the group with gabhs. this difference was due mostly to the lower incidence of beta-lact ... | 1988 | 3132074 |
| host range of the conjugative 25.2-megadalton tetracycline resistance plasmid from neisseria gonorrhoeae and related species. | high-level tetracycline resistance in strains of neisseria gonorrhoeae, neisseria meningitidis, kingella denitrificans, and eikenella corrodens has recently been described. the resistance in each species is due to the acquisition of 25.2-megadalton conjugative plasmids that carry the tetracycline resistance determinant tetm. we examined the ability of commensal neisseria species to serve as recipients in conjugation for these new plasmids. most of the recipients (n = 21) tested had detectable co ... | 1988 | 3132092 |
| evaluation of a ten-minute chromogenic substrate test for identification of pathogenic neisseria species and branhamella catarrhalis. | a ten-minute chromogenic substrate test was evaluated for its ability to rapidly identify pathogenic neisseria spp. and branhamella catarrhalis. identifications obtained with this system were compared to those obtained using conventional procedures. the test correctly identified 98.9% of 90 neisseria gonorrhoeae, 98.3% of 60 neisseria meningitidis, 96.2% of 26 neisseria lactamica, and 100% of 36 branhamella catarrhalis strains. eight neisseria subflava strains that grew on modified thayer-martin ... | 1988 | 3132371 |
| comparative antimicrobial activity of the new macrolide flurithromycin against respiratory pathogens. | the activity of flurithromycin against haemophilus influenzae, streptococcus pneumoniae, streptococcus pyogenes, branhamella catarrhalis and staphylococcus aureus was determined by the agar dilution method. flurithromycin showed high activity against streptococcus pneumoniae, streptococcus pyogenes and branhamella catarrhalis (mic90 = 0.032-0.25 mg/l). its mic90 value against haemophilus influenzae strains was 4.0 mg/l and 16 mg/l against staphylococcus aureus strains. flurithromycin has promisi ... | 1988 | 3132384 |
| the effects of sinus bacteria on human ciliated nasal epithelium in vitro. | the mechanisms by which bacteria colonize and damage ciliated epithelium are important in understanding the pathophysiology of rhinitis, sinusitis, and otitis. bacteria that have the ability to impair mucociliary clearance would be at an advantage in establishing infection of ciliated surfaces. this study investigates the effect of hemophilus influenzae, streptococcus pneumoniae, branhamella catarrhalis, and staphylococcus epidermidis on the ciliary activity of normal ciliated nasal epithelium i ... | 1988 | 3132682 |
| [branhamella catarrhalis infection]. | 1988 | 3133094 | |
| rapid identification of branhamella catarrhalis with 4-methylumbelliferyl butyrate. | branhamella catarrhalis can be distinguished from neisseria spp. by the presence of butyrate esterase. this enzyme can be rapidly detected when 4-methylumbelliferyl butyrate is used as the substrate. all b. catarrhalis strains tested gave a positive fluorescence reaction within 5 min, while neisseria spp. remained negative, even after 18 h of incubation. | 1988 | 3133392 |
| profiles of amino-acid utilisation and production amongst strains of branhamella catarrhalis. | utilisation and production of amino acids by isolates of branhamella catarrhalis was studied by ion exchange chromatography after cells had been grown in nutrient broth and mueller-hinton broth. the profiles of amino acids used and produced by each strain were compared by a single linkage cluster algorithm. the results of this study reflect the biochemical and physiological heterogeneity amongst strains of b. catarrhalis. | 1988 | 3133481 |
| [branhamella catarrhalis: incidence in pulmonary infections and determination of sensitivity to 5 antibiotics]. | this study reports 45 cases of respiratory tract infection associated with branhamella catarrhalis, diagnosed by bacteriological examination out of 980 sputum samples studied over a 6 months period. these infections were observed mainly in patients with chronic respiratory disease (68.9%). more than half of the isolates were found in pure culture, others were isolated from mixed infections most often with haemophilus influenzae, streptococcus pneumoniae or h. influenzae plus s. pneumoniae. 64.7% ... | 1988 | 3136431 |
| bactericidal activity of bmy-28100 versus amoxicillin/clavulanic acid against branhamella catarrhalis. | 1988 | 3137055 | |
| [respiratory infections caused by branhamella catarrhalis: clinical analysis concerning its pathogenicity]. | 1988 | 3137299 | |
| adherence of branhamella catarrhalis to human pharyngeal cells: its role in the pathogenesis of lower respiratory infection. | 1988 | 3138342 | |
| the epidemiology of respiratory tract pathogens in southern netherlands. | results of sputum cultures and susceptibility tests have been reviewed for the years 1977-1986, with approximately 1,700 positive cultures per year. haemophilus influenzae always occupied the first place, being grown in 65% of positive specimens in 1977 and 37% in 1986. streptococcus pneumoniae occupied the second place, rising from 17 to 27% in the same period, during which branhamella catarrhalis rose from 5 to 26%. based on the frequency of occurrence of individual bacterial species in the sp ... | 1988 | 3139445 |
| laboratory diagnosis of branhamella catarrhalis. | 1988 | 3139719 | |
| comparison of the outer membrane proteins of 50 strains of branhamella catarrhalis. | branhamella catarrhalis colonizes the respiratory tract of humans and commonly causes otitis media in children and respiratory infections in adults with chronic lung disease. in view of the emergence of this organism as an important human pathogen, we used sodium dodecyl sulfate-polyacrylamide gel electrophoresis (sds-page) to examine the outer membrane proteins (omps) of 50 strains of b. catarrhalis. omps were isolated from broth culture supernatants. typical of other gram-negative bacteria, ei ... | 1988 | 3139777 |
| branhamella catarrhalis sepsis: a case report and review of the literature. | 1988 | 3139780 | |
| recurrent and penicillin v-resistant otitis media. a treatment study with amoxycillin/clavulanate and cefaclor. | clinical and bacteriological studies were performed in 122 children, aged 1-10 years, with recurrent otitis media or failed therapy with phenoxymethyl penicillin. a specimen for bacteriological culture was taken from the nasopharynx in all patients, and in our material haemophilus influenzae, branhamella catarrhalis and streptococcus pneumoniae were equally distributed, each forming one-third of the total bacterial count. thus, h. influenzae and b. catarrhalis (as well as their betalactamase-pro ... | 1988 | 3140574 |
| branhamella catarrhalis meningitis following otolaryngologic surgery. | a case of pyogenic meningitis caused by branhamella catarrhalis which occurred after pharyngoplasty, adenoidectomy and tympanostomy tube placement is reported. this organism is morphologically similar to neisseria meningitidis but often produces beta lactamase. therefore therapy should be directed by proper microbiologic identification and sensitivity results. | 1988 | 3140851 |
| efficacy of penicillin treatment in purulent maxillary sinusitis. a european multicenter trial. | three hundred and one patients with maxillary sinusitis participated in a double-blind, randomized study at 11 ent-clinics in europe. sinusitis was diagnosed by the presence of at least two signs and symptoms and sinus x-ray showing more than 6 mm swelling of the maxillary mucosa. a microbiological specimen was obtained by intrasinusal aspiration. the patients were randomly assigned to treatment either with bacampillin 800 mg b. i. d. or with amoxicillin 500 mg t. i. d. for ten days. the most fr ... | 1988 | 3141290 |
| spiramycin: in-vitro activity on branhamella catarrhalis. | this in-vitro study of susceptibility to spiramycin of 103 strains of branhamella catarrhalis isolated between 1982 and 1987 was performed by evaluation of their mics. more than 97% of strains remained susceptible with mic less than or equal to 8 mg/l (two strains). one strain presented a mic of 16 mg/l. there were no significant differences of susceptibility to spiramycin between penicillinase-producing and non-producing strains. | 1988 | 3141349 |
| [in vitro activity of 3 fluoroquinolones on branhamella catarrhalis]. | the in vitro antibacterial activities of three fluoroquinolones (pefloxacin, ofloxacin, ciprofloxacin) against 90 clinical isolates of branhamella catarrhalis were assessed by determination of minimum inhibitory concentrations (mics). 73.5% of the strains were producing penicillinase. the mics90 were as follow: ciprofloxacin = 0.2 mg/l. the mic50 and the mic90 were similar. there was no correlation of mics with beta-lactam resistance. lung parenchyma and bronchial mucus diffusion of these three ... | 1988 | 3141885 |
| branhamella catarrhalis bacteremia in children. | 1988 | 3141896 | |
| plasma bactericidal activity after administration of erythromycin estolate and erythromycin ethylsuccinate to healthy volunteers. | in a crossover design study, we compared the plasma bactericidal activities of erythromycin estolate (500 mg) and erythromycin ethylsuccinate (600 mg) after administration of a single oral dose to 12 healthy volunteers. both erythromycin esters displayed very good plasma bactericidal activities against streptococcus pneumoniae. the median bactericidal titers produced in plasma against streptococcus pyogenes and streptococcus pneumoniae were significantly higher with erythromycin estolate than wi ... | 1988 | 3142349 |
| rate of bactericidal activity for branhamella catarrhalis of fleroxacin compared with that of amoxycillin-clavulanic acid. | the rate of bactericidal activity of fleroxacin was compared with that of the combination of amoxycillin and clavulanic acid (in the proportion of 4 to 1) on beta-lactamase producing strains of branhamella catarrhalis. the rate of bactericidal activity of 1 mg/l was as rapid as that of 1 mg/l of amoxycillin-clavulanic acid combination. this rate was not significantly more rapid if the concentrations of fleroxacin were increased to 10 mg/l. in conclusion, the bactericidal activity of fleroxacin i ... | 1988 | 3144548 |
| the antibiotic susceptibilities and beta-lactamase production of clinical isolated branhamella catarrhalis from acute otitis media in children. | branhamella catarrhalis has been misconsidered as a normal resident in human respiratory tract for a long time. however, many authors recently have reported its pathogenecity and isolated it from the otolaryngological region. in our study, this organism can be isolated from the ear and nasal discharge in the child with acute otitis media by the rate of 7.5% and 21.4% respectively. out of this 107 isolated strains, 97 strains (90.7%) were found to be beta-lactamase producing organisms. the mic me ... | 1988 | 3144965 |
| branhamella catarrhalis septicemia in an infant with aids. | branhamella catarrhalis was isolated in blood culture from a 6-month-old infant with aids. the child had a nasopharyngeal infection with respiratory syncytial virus and pneumonitis with pneumocystis carinii. commensal organisms such as b. catarrhalis may be potential pathogens in infants with aids. | 1988 | 3146808 |
| pneumonia due to branhamella catarrhalis. | in 12 of 451 patients diagnosed as having pneumonia in a single hospital over 18 months the causative organism appeared to be branhamella catarrhalis. | 1988 | 3146819 |
| in vitro evaluation of ceftibuten (7432-s, sch 39720), a novel orally administered cephalosporin. | 7432-s (sch 39720) was the most active beta-lactam tested against the enterobacteriaceae, inhibiting 92% of strains at less than or equal to 8.0 micrograms/ml compared to 82%, 65% and 39% of strains inhibited by cefixime, cefuroxime and cefaclor, respectively. 7432-s was also very effective against haemophilus influenzae (mic90, less than or equal to 0.25 microgram/ml), branhamella catarrhalis (mic90, 4.0 micrograms/ml) and neisseria meningitidis (mic90, less than or equal to 0.25 microgram/ml). ... | 1988 | 3147148 |
| branhamella catarrhalis: fatty acid and lipopolysaccharide analysis of an atypical strain from blood culture. | a branhamella catarrhalis-like organism was isolated from blood cultures; it was atypical in showing negative nitrate and nitrite and positive gamma-glutamylaminopeptidase reactions, in agglutinating with neisseria meningitidis antisera, and in forming butyrous colonies. cell-wall fatty-acid and lipopolysaccharide analysis provided evidence that this isolate was an atypical b. catarrhalis. | 1988 | 3147160 |
| selective medium for branhamella catarrhalis with acetazolamide as a specific inhibitor of neisseria spp. | several semiselective media for branhamella catarrhalis have been proposed. these media allow growth of all members of the family neisseriaceae, and further differentiation is necessary. by addition of 10 micrograms of acetazolamide, a carbonic anhydrase inhibitor, per ml and incubation in air, a medium was created which reduced growth of neisseria spp. when saliva samples from 178 healthy schoolchildren were screened for the presence of b. catarrhalis, the carrier rate for this organism was est ... | 1988 | 3147992 |
| characterization of a plasmid isolated from branhamella catarrhalis and detection of plasmid sequences within the genome of a b. catarrhalis strain. | we isolated a 12.2-kb plasmid from two clinical strains of branhamella catarrhalis and evaluated its distribution among other b. catarrhalis strains by colony hybridization experiments using the whole plasmid as a probe. homology was detected with the two plasmid-bearing strains and also with a third b. catarrhalis strain named e7, which is plasmidless. southern transfer analysis of total digested e7 dna using the purified plasmid as a probe revealed a single band of hybridization, different fro ... | 1988 | 3148947 |
| [recent trend of incidence of respiratory pathogenic bacteria and its susceptibility to antimicrobial agents: studies in the year 1984-1986]. | based on a quantitative analysis of sputum cultures, pathogenic bacteria in respiratory ailments isolated in our laboratory during 1984 to 1986 were classified and analyzed. during the study period, the most frequently isolated agent was haemophilus influenzae followed by pseudomonas aeruginosa, branhamella catarrhalis and streptococcus pneumoniae. they together consisted of 70 approximately 74% of all the respiratory pathogenic bacteria isolated in our study. susceptibilities of above pathogens ... | 1988 | 3149325 |
| [clinical experience with ofloxacin in the treatment of chronic respiratory tract disease aggravated by acute infection]. | we studied the clinical usefulness of ofloxacin (oflx) in 13 patients with chronic respiratory tract diseases aggravated by acute infections with identified causative bacteria. 1. overall clinical efficacies were: highly effective 5, effective 6, slightly effective 2, and ineffective none, showing an efficacy rate of 84.6%. 2. in 6 patients with fever of over 37 degrees c, time lengths in days for symptoms to have been alleviated due to oflx treatment were; 1 day: 4 cases, 3 days: 1 case and 5 d ... | 1988 | 3149326 |
| in-vitro activity of amoxycillin/clavulanic acid and five other oral antibiotics against clinical isolates of haemophilus influenzae and branhamella catarrhalis. | the in-vitro activity of amoxycillin/clavulanic acid, amoxycillin, erythromycin, doxycycline, chloramphenicol and cephalexin against 183 clinical isolates of haemophilus influenzae and 61 of branhamella catarrhalis was determined. amoxycillin/clavulanic acid showed the greatest activity against h. influenzae. all isolates of b. catarrhalis were susceptible to amoxycillin/clavulanic acid, chloramphenicol, cephalexin and doxycycline. | 1988 | 3149634 |
| [branhamella catarrhalis and bronchopulmonary infection]. | 1988 | 3149788 | |
| antimicrobial susceptibility testing of haemophilus influenzae, branhamella catarrhalis, and neisseria gonorrhoeae. | 1988 | 3149883 | |
| selective medium with dnase test agar and a modified toluidine blue o technique for primary isolation of branhamella catarrhalis in sputum. | a selective medium with dnase test agar and incorporating vancomycin (10 micrograms/ml), trimethoprim (8 micrograms/ml), and amphotericin b (2 micrograms/ml) supported the growth of 305 branhamella catarrhalis isolates. a modified toluidine blue o technique was used after 48 h of incubation in co2 to overlay suspected b. catarrhalis colonies. a metachromatic color change was observed in 15 min, indicating dnase production. in 200 unselected sputum samples of hospitalized patients, this method wa ... | 1988 | 3128575 |
| evaluation of eight methods for identification of pathogenic neisseria species: neisseria-kwik, rim-n, gonobio-test, minitek, gonochek ii, gonogen, phadebact monoclonal gc omni test, and syva microtrak test. | the performance of eight methods in identifying neisseria species, particularly n. gonorrhoeae, was evaluated. these methods included four rapid carbohydrate utilization tests (gonobio-test, neisseria-kwik, rim-n, and minitek); the gonochek ii, a test which is based on the utilization of chromogenic substrates; and three monoclonal antibody tests (syva microtrak, gonogen, and phadebact monoclonal gc omni test). in all, 182 isolates comprised in six species of neisseria as well as branhamella cat ... | 1988 | 3128578 |
| antimicrobial resistance in branhamella catarrhalis. | 1988 | 3129387 | |
| enoxacin in acute exacerbations of chronic bronchitis: a comparison with amoxycillin. | a total of 43 hospitalized adult patients with acute exacerbations of chronic bronchitis or bronchiectasis due to gram-negative bacteria were randomized to receive either enoxacin (400 mg bd) or amoxycillin (1,000 mg tid) for 7-12 days. micro-organisms isolated included 24 haemophilus influenzae (three beta-lactamases positive), 11 branhamella catarrhalis (six beta-lactamase positive), two pseudomonas aeruginosa and two neisseria meningitidis in 37 evaluable patients. in the enoxacin group (23 p ... | 1988 | 3129390 |
| immunoglobulin g (igg) serological response to branhamella catarrhalis in patients with acute bronchopulmonary infections. | over 12 months serum was collected from 45 inpatients, with acute bronchopulmonary infection, in whose sputum branhamella catarrhalis predominated, or was the sole pathogen. serum was examined for igg against b catarrhalis using an immunofluorescence antibody test. acute and convalescent sera were compared with sera of age and sex matched controls. the convalescent sera had significantly higher titres than the acute sera which in turn had higher titres than the controls. the findings confirm the ... | 1988 | 3129454 |
| newer oral antimicrobials and newer etiologic agents of acute bronchitis and acute exacerbations of chronic bronchitis. | although the role of antimicrobial therapy in the treatment of chronic bronchitis is unproven, physicians continue to look for microbial etiologies to explain episodes of clinical acute bronchitis and better antimicrobial agents with which to treat these episodes. the newest major pathogen of acute bronchitis is branhamella catarrhalis, a neisseriae-like organism that has become the third most commonly recognized cause of this disease after haemophilus influenzae and streptococcus pneumoniae. be ... | 1988 | 3129770 |
| in vitro activities of 39 antimicrobial agents for branhamella catarrhalis and comparison of results with different quantitative susceptibility test methods. | the in vitro activities of 39 antimicrobial agents were assessed versus 74 clinical isolates of branhamella catarrhalis. resistance was observed only with penicillin and ampicillin and then only with beta-lactamase-producing strains. the results of in vitro susceptibility tests with agar dilution and broth microdilution procedures were found to be comparable. the results of broth tube macrodilution tests were, in general, one twofold-concentration increment higher. | 1988 | 3129988 |
| in vitro susceptibilities of common pediatric pathogens to ly163892. | ly163892 is a carbacephem antibiotic for oral administration with an antibacterial spectrum similar to that of cefaclor and amoxicillin-clavulanic acid. it has greater stability than cefaclor and greater activity against beta-lactamase-producing haemophilus influenzae and escherichia coli. ly163892 is less active than amoxicillin against streptococci and less active than amoxicillin-clavulanic acid against branhamella catarrhalis but comparable against other pathogens. | 1988 | 3129989 |
| emergence and persistence of beta-lactamase-producing bacteria in the oropharynx following penicillin treatment. | the emergence and persistence of aerobic and anaerobic beta-lactamase-producing bacteria (blpb) were investigated in 26 children treated with penicillin for otitis media or pharyngitis and in 28 nontreated control children. beta-lactamase-producers were isolated in three (12%) of the treated children before therapy, in 12 (46%) seven to ten days after completion of therapy, in nine (35%) 40 to 45 days after therapy, and in seven (27%) 85 to 90 days after therapy. these organisms were present in ... | 1988 | 3130087 |
| [laboratory and clinical studies on cefotetan in respiratory tract infections]. | seventy five patients with respiratory infections, including 40 cases of acute pneumonia, 33 cases of secondary infection after chronic pulmonary diseases and 2 cases of pulmonary abscess, were treated with cefotetan (ctt, yamatetan) by drip infusion in order to evaluate its clinical efficacy. the overall rate of effectiveness was 83.8%. ctt was examined comparatively with other beta-lactam antibiotics for antibacterial activity on clinically isolated strains of 3 major respiratory pathogens inc ... | 1988 | 3043035 |
| [studies on susceptibility of isolated organisms from pediatric infections against various antimicrobial agents]. | twelve oral antimicrobial agents were tested for their antimicrobial activities against causative organisms isolated from pediatric infections. activities of these antimicrobial agents against streptococcus pyogenes were also examined in relation to t-antigen typing of the species. the results of the investigation are summarized as follows. 1. against staphylococcus aureus, rokitamycin (rkm), josamycin, ofloxacin, minocycline exhibited strong antimicrobial activities, and few strains of s. aureu ... | 1988 | 3050184 |
| comparative in-vitro activity of a new oral carbacephem, ly163892. | the in-vitro activity of a new oral carbacephem, ly163892, was compared with cefaclor, cephalexin, cephradine, cefadroxil and selected penicillins against 529 bacterial isolates. ly163892 exhibited greater activity in vitro than all four cephalosporins against haemophilus influenzae, beta-lactamase producing branhamella catarrhalis, escherichia coli, klebsiella spp. and proteus mirabilis. ly163892 had equivalent potency to cefaclor against non-beta-lactamase producing b. catarrhalis, streptococc ... | 1988 | 3060458 |
| cefuroxime axetil. | cefuroxime axetil is a orally active prodrug formulation of cefuroxime, which upon absorption undergoes immediate deesterification to free cefuroxime. cefuroxime axetil offers an in vitro antibacterial spectrum against many gram-positive and some gram-negative organisms. its beta-lactamase stability makes it useful in treating a variety of infections caused by beta-lactamase-producing strains of haemophilus influenzae, branhamella catarrhalis, and staphylococcus aureus. cefuroxime axetil has goo ... | 1988 | 3063476 |
| [clinical trials of flomoxef in patients with chronic respiratory tract infections]. | flomoxef (fmox, 6315-s), a newly developed oxacephem drug, was administered to 6 patients with chronic respiratory tract infections. bacteriological examination of these infections using quantitative sputum cultures revealed that 2 patients had haemophilus influenzae, 2 had branhamella catarrhalis and 2 had mixed pathogens (one was with h. influenzae + b. catarrhalis and the other with streptococcus pneumoniae + b. catarrhalis). the administration of the drug was done by drip infusion, twice dai ... | 1988 | 3063850 |
| management of otitis media in infants and children: current role of old and new antimicrobial agents. | otitis media, the diagnosis most frequently made by the pediatrician, is most effectively treated with antimicrobial therapy. amoxicillin (or ampicillin) has been the standard for infants and children with acute otitis media because it is safe and effective for most of the causative bacterial pathogens. amoxicillin has also been shown to be effective for treatment of some children with otitis media with effusion ("secretory" otitis media) and is the recommended prophylactic antimicrobial agent f ... | 1988 | 3064037 |
| sinusitis in children. | upper respiratory tract infection and allergic inflammation are recognized as the important risk factors for acute sinusitis, with upper respiratory tract infection being most common. in children with acute or chronic sinusitis, the respiratory symptoms of nasal discharge, nasal congestion and cough are usually prominent. radiography has traditionally been used to determine the presence or absence of sinus disease. the radiographic findings most diagnostic of bacterial sinusitis are diffuse opac ... | 1988 | 3064040 |
| panel of reference strains for evaluating serologic reagents used to identify gonococci. | a panel of strains for evaluating neisseria gonorrhoeae serologic reagents was developed. the strains selected for the panel were antigenically diverse and representative of strains isolated worldwide and had been isolated from a variety of anatomic sites. a few strains with characteristics that can cause problems in serologic tests were included. the panel of 52 gonococcal and 20 nongonococcal strains was used to evaluate two commercially produced kits with monoclonal antibody reagents, gonogen ... | 1988 | 3125222 |
| imipenem-cilastatin in the treatment of respiratory infections in patients with chronic airways obstruction. | chest infections with organisms resistant to conventional antibiotics are common in patients with chronic lung disease. we have studied the use of imipenem in 40 (28 m 12 f) patients admitted for treatment of chest infections. patients were treated with imipenem 0.5 g four times daily by intravenous infusion for 6.3 +/- 1.6 (s.d.) days. forty-six respiratory pathogens were cultured from 36 patients including 18 haemophilus influenzae, 6 h. parainfluenzae, 6 streptococcus pneumoniae, 8 pseudomona ... | 1988 | 3356618 |
| in vitro activity of flomoxef in comparison to other cephalosporins. | flomoxef and cefazolin had nearly the same activity against staphylococci, which was stronger than that of other cephalosporins. against streptococcus pyogenes, streptococcus agalactiae and streptococcus pneumoniae, cefotaxime and cefazolin were more active than flomoxef, but the other cephamycins were less active than flomoxef. in comparison to the other cephalosporins, latamoxef and flomoxef had higher activity against branhamella catarrhalis, whereas cefotaxime, latamoxef and cefotetan were m ... | 1988 | 3372024 |
| antimicrobial activity and disk diffusion susceptibility testing of u-76,253a (r-3746), the active metabolite of the new cephalosporin ester, u-76,252 (cs-807). | compound u-76,253a (r-3746), the active metabolite sodium salt of the prodrug ester u-76,252 (cs-807), was demonstrated to be active against members of the family enterobacteriaceae with 82 and 85% of strains inhibited by less than or equal to 2.0 and less than or equal to 4.0 micrograms/ml, respectively. in addition, u-76,253a inhibited all strains of branhamella catarrhalis, haemophilus influenzae, pathogenic neisseria spp., oxacillin-susceptible staphylococcus aureus, beta-hemolytic streptoco ... | 1988 | 3377457 |
| prevalence and persistence of neisseria cinerea and other neisseria spp. in adults. | neisseria cinerea is a commensal neisseria sp. which was first described in 1906 but was subsequently misclassified as a subtype of branhamella catarrhalis. n. cinerea resembles neisseria gonorrhoeae in both cultural and biochemical characteristics and, thus, may also have been misidentified as n. gonorrhoeae. of 202 patients whose oropharynges were colonized by neisseria spp., n. cinerea was isolated in 57 (28.2%) patients, including 25 (30.1%) of 83 women, 22 (23.9%) of 92 heterosexual men, an ... | 1988 | 3384913 |
| branhamella catarrhalis septicemia in patients with leukemia. | during a 10-year period, four patients with leukemia were identified who had branhamella catarrhalis septicemia. two patients had acute leukemia and the remaining two had chronic myelogenous leukemia with blastic transformation. all patients were febrile and neutropenic at the onset of the septicemia. after appropriate antibiotic therapy, they recovered from their infection despite persistence of neutropenia. because beta-lactamase-producing bacteria are an increasing cause of nosocomial infecti ... | 1988 | 3130177 |
| evaluation of a rapid method for identifying branhamella catarrhalis. | the speed and precision of hydrolysis of tributyrin to butyric acid as a test to detect branhamella catarrhalis were evaluated. the test proved consistently reliable in the identification of strains and correctly differentiated b catarrhalis from neisseria sp. the combination of gram stain, oxidase, and catalase tests to tributyrin hydrolysis provides a means of positive same day identification of b catarrhalis. | 1988 | 3130412 |
| in vitro antibacterial activity of trospectomycin (u-63366f), a novel spectinomycin analog. | trospectomycin (u-63366f) is a novel spectinomycin analog with broad-spectrum antibacterial activity. the in vitro activity of this analog was compared with that of spectinomycin and other reference antibiotics against 411 clinical isolates of aerobic and anaerobic bacteria. mics were determined by agar or broth dilution methods. the stability of trospectomycin in the presence of an enzyme extract derived from spectinomycin-resistant escherichia coli was determined. trospectomycin was more activ ... | 1988 | 2966608 |
| trospectomycin, a novel spectinomycin analogue: antibacterial activity and preliminary human pharmacokinetics. | trospectomycin (tsp; u-63366f) is a novel spectinomycin (sp) analogue with broad-spectrum antibacterial activity. the in vitro activity of the analogue was compared to that of sp against approximately 400 bacterial isolates. the in vivo activity of the compound was assessed using experimental infection models for both gram-positive and gram-negative facultative bacteria. the preliminary human pharmacokinetics of tsp were evaluated following single-dose i.v. or i.m. administration. tsp was more a ... | 1988 | 2975212 |
| [laboratory and clinical studies of rokitamycin dry syrup in the field of pediatrics]. | laboratory and clinical studies on rokitamycin (rkm) dry syrup, a new macrolide antibiotic, were carried out in the field of pediatrics. the results are summarized as follows. 1. plasma concentrations and urinary recovery rates after oral administration on fasting of rkm dry syrup at doses of 10 mg/kg and 20 mg/kg to 2 and 1 cases, respectively, were determined. peak plasma levels were obtained in 30 minutes after administration of both dosages with half-lives of 1.5 to 2.2 hours. a clear-cut do ... | 1988 | 3172461 |
| in-vitro and in-vivo activities of t-3262, a new pyridone carboxylic acid. | t-3262[p-toluenesulfonic acid salt of dl-7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1, 4-dihydro-4-oxo-1, 8-naphthyridine-3-carboxylic acid monohydrate] is a new pyridone carboxylic acid with a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria. the activity of t-3262 against most enterobacteriaceae was comparable with that of ciprofloxacin except proteus spp. and providencia rettgeri and exceeded that of ofloxacin and norfloxacin. the activ ... | 1988 | 3182417 |
| comparative in-vitro activity of tigemonam, a new monobactam. | the in-vitro activity against gram-negative aerobic bacterial pathogens of a new oral monobactam, tigemonam, was compared with those of amoxycillin/clavulanic acid, aztreonam, cefaclor, ceftazidime, cefuroxime, ciprofloxacin, co-trimoxazole and gentamicin, by an agar-dilution method. tigemonam inhibited 90% of strains tested of escherichia coli, klebsiella spp., proteus spp., salmonella spp., haemophilus influenzae and branhamella catarrhalis at concentrations of 0.25 mg/l or below. the mic90 fo ... | 1988 | 3182428 |
| antimicrobial activity of ly163892, an orally administered 1-carbacephem. | ly163892 was found to be similar to cefaclor and slightly superior to cephalexin in antimicrobial activity and spectrum. bacteria with mic50 less than or equal to 8.0 mg/l included escherichia coli, klebsiella spp., proteus mirabilis, citrobacter diversus, haemophilus influenzae, branhamella catarrhalis, pathogenic neisseria spp., oxacillin-susceptible staphylococci, and streptococcus spp. strains that produced plasmid-mediated beta-lactamases generally remained susceptible to ly163892. ly163892 ... | 1988 | 3182429 |
| bacteriological findings of acute maxillary sinusitis in young adults. | bacteriological findings in 339 sinus secretions obtained by puncture were investigated in 238 young adult patients with acute maxillary sinusitis. aerobic and anaerobic cultures were performed immediately. a total of 76% of the secretions were positive. the most common pathogens isolated were haemophilus influenzae (50%), streptococcus pneumoniae (19%), streptococcus pyogenes (5%), and branhamella catarrhalis (2%). coagulase-negative staphylococci and staphylococcus aureus were isolated in 8 an ... | 1988 | 3182986 |
| antimicrobial activity, spectrum, and recommendations for disk diffusion susceptibility testing of ceftibuten (7432-s; sch 39720), a new orally administered cephalosporin. | the antimicrobial activity and spectrum of ceftibuten (7432-s; sch 39720) was determined on a wide variety of bacterial species selected for resistance to oral and parenteral beta-lactam antimicrobial agents. ceftibuten was found to be the most active beta-lactam tested against members of the family enterobacteriaceae, inhibiting 81.6% of strains at less than or equal to 8.0 micrograms/ml compared with 75.0 and 54.8% of strains inhibited by cefixime and cefuroxime, respectively. all strains of h ... | 1988 | 3190185 |
| in vitro activity of u-76,252 (cs-807), a new oral cephalosporin. | u-76,252 is the prodrug of u-76,253. mics of u-76,253 were 0.015 to 0.06 microgram/ml for greater than or equal to 90% of the strains of streptococcus spp., haemophilus influenzae, and proteus mirabilis; 0.25 to 1 microgram/ml for branhamella catarrhalis, escherichia coli, klebsiella spp., and citrobacter diversus; 1 to 8 micrograms/ml for staphylococcus spp.; and 2 to greater than 16 micrograms/ml for other members of the family enterobacteriaceae and aeromonas hydrophila; for 72% of the latter ... | 1988 | 3190194 |