Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| comparative analyses of legionella species identifies genetic features of strains causing legionnaires' disease. | the genus legionella comprises over 60 species. however, l. pneumophila and l. longbeachae alone cause over 95% of legionnaires’ disease. to identify the genetic bases underlying the different capacities to cause disease we sequenced and compared the genomes of l. micdadei, l. hackeliae and l. fallonii (llap10), which are all rarely isolated from humans. | 2014 | 25370836 |
| toxoplasma effector maf1 mediates recruitment of host mitochondria and impacts the host response. | recent information has revealed the functional diversity and importance of mitochondria in many cellular processes including orchestrating the innate immune response. intriguingly, several infectious agents, such as toxoplasma, legionella, and chlamydia, have been reported to grow within vacuoles surrounded by host mitochondria. although many hypotheses have been proposed for the existence of host mitochondrial association (hma), the causes and biological consequences of hma have remained unansw ... | 2014 | 24781109 |
| genomic investigation of a legionellosis outbreak in a persistently colonized hotel. | a long-lasting legionellosis outbreak was reported between november 2011 and july 2012 in a hotel in calpe (spain) affecting 44 patients including six deaths. intensive epidemiological and microbiological investigations were performed in order to detect the reservoirs. | 2015 | 26834713 |
| genomic investigation of a legionellosis outbreak in a persistently colonized hotel. | a long-lasting legionellosis outbreak was reported between november 2011 and july 2012 in a hotel in calpe (spain) affecting 44 patients including six deaths. intensive epidemiological and microbiological investigations were performed in order to detect the reservoirs. | 2015 | 26834713 |
| atypical presentation of legionella pneumonia among patients with underlying cancer: a fifteen-year review. | immunocompromised patients, especially those receiving treatment with corticosteroids and cytotoxic chemotherapy are at increased risk for developing legionella pneumonia. | 2015 | 26496794 |
| atypical presentation of legionella pneumonia among patients with underlying cancer: a fifteen-year review. | immunocompromised patients, especially those receiving treatment with corticosteroids and cytotoxic chemotherapy are at increased risk for developing legionella pneumonia. | 2015 | 26496794 |
| prevalence and molecular characteristics of waterborne pathogen legionella in industrial cooling tower environments. | cooling towers are a source of legionnaires' disease. it is important from a public health perspective to survey industrial cooling towers for the presence of legionella. prospective surveillance of the extent of legionella pollution was conducted at factories in shijiazhuang, china between march 2011 and september 2012. overall, 35.7% of 255 industrial cooling tower water samples showed legionella-positive, and their concentrations ranged from 100 colony-forming units (cfu)/liter to 88,000 cfu/ ... | 2015 | 26473896 |
| legionella micdadei: a forgotten etiology of growing cavitary nodules: a case report and literature review. | background. legionella micdadei is a gram negative bacterium that can stain weakly acid fast. it was first described in 1979 after immunosuppressed patients developed pneumonia at a pittsburgh va, initially given the name pittsburgh pneumonia agent. it is the second most common legionella species causing infection after pneumophila, and typically infects immunocompromised hosts. it is not easy to be cultured which makes diagnosing difficult. case presentation. a 31-year-old female with ulcerativ ... | 2015 | 26451267 |
| utility of pcr, culture, and antigen detection methods for diagnosis of legionellosis. | the goal of this retrospective study was to evaluate the performance of different diagnostic tests for legionnaires' disease in a clinical setting where legionella pneumophila pcr had been introduced. electronic medical records at the cleveland clinic were searched for legionella urinary antigen (uag), culture, and pcr tests ordered from march 2010 through december 2013. for cases where two or more test methods were performed and at least one was positive, the medical record was reviewed for rel ... | 2015 | 26292304 |
| rash, disseminated intravascular coagulation and legionella: episode 10 and a rewind into the past. | legionella pneumophila is the most common cause of legionellosis and is one of the organisms causing atypical pneumonia. we report the presentation of disseminated intravascular coagulation (dic) and skin rash in a single case of severe legionella pneumonia. the unique clinical presentation of a diffuse rash diagnosed as purpura fulminans and the unpredictable variations encountered during the diagnostic work-up of the case make this write-up crucial. this article synthesizes all reported cases ... | 2015 | 26236615 |
| microbiological and clinical studies of legionellosis in 33 patients with cancer. | legionella, a large group of environmental gram-negative bacteria, represents an occasional cause of pneumonia. we analyzed the microbiological and clinical features of 33 consecutive cases of legionella infections that occurred at the university of texas md anderson cancer center, houston, tx, from 2002 to 2014. the legionella strains were isolated from bronchoscopy specimens (32 strains) and a blood culture (1 strain) and were identified by sequencing analysis of the full-length 16s rrna gene. ... | 2015 | 25926494 |
| mistaken identity: legionella micdadei appearing as acid-fast bacilli on lung biopsy of a hematopoietic stem cell transplant patient. | legionella micdadei is a potential cause of invasive lung infections in immunocompromised hosts. on biopsy specimens, it can appear as an acid-fast bacillus (afb) and can be mistaken for a member of genus mycobacterium. as legionella requires selective media to grow in culture, and the commonly used, commercially available urine antigen test for legionella only detects legionella pneumophila serogroup-1, but not l. micdadei, it is important to consider this organism in the differential diagnosis ... | 2015 | 25573597 |
| 15(th) annual southern hospital medicine conference abstracts. | 2015 | 25829893 | |
| role of innate t cells in anti-bacterial immunity. | innate t cells are a heterogeneous group of αβ and γδ t cells that respond rapidly (<2 h) upon activation. these innate t cells also share a non mhc class i or ii restriction requirement for antigen recognition. three major populations within the innate t cell group are recognized, namely, invariant nkt cells, mucosal associated invariant t cells, and gamma delta t cells. these cells recognize foreign/self-lipid presented by non-classical mhc molecules, such as cd1d, mr1, and cd1a. they are acti ... | 2015 | 26124758 |
| oxidative stress control by apicomplexan parasites. | apicomplexan parasites cause infectious diseases that are either a severe public health problem or an economic burden. in this paper we will shed light on how oxidative stress can influence the host-pathogen relationship by focusing on three major diseases: babesiosis, coccidiosis, and toxoplasmosis. | 2015 | 25722976 |
| a side by side comparison of bruker biotyper and vitek ms: utility of maldi-tof ms technology for microorganism identification in a public health reference laboratory. | matrix-assisted laser desorption ionization-time of flight mass spectrometry (maldi-tof ms) has emerged as a rapid, highly accurate, and cost-effective method for routine identification of a wide range of microorganisms. we carried out a side by side comparative evaluation of the performance of bruker biotyper versus vitek ms for identification of a large and diverse collection of microorganisms. most difficult and/or unusual microorganisms, as well as commonly encountered microorganisms were se ... | 2015 | 26658918 |
| microbial contamination of drinking water and human health from community water systems. | a relatively short list of reference viral, bacterial and protozoan pathogens appears adequate to assess microbial risks and inform a system-based management of drinking waters. nonetheless, there are data gaps, e.g. human enteric viruses resulting in endemic infection levels if poorly performing disinfection and/or distribution systems are used, and the risks from fungi. where disinfection is the only treatment and/or filtration is poor, cryptosporidiosis is the most likely enteric disease to b ... | 2015 | 25821716 |
| nontuberculous mycobacterial ocular infections: a systematic review of the literature. | nontuberculous or atypical mycobacterial ocular infections have been increasing in prevalence over the past few decades. they are known to cause periocular, adnexal, ocular surface and intraocular infections and are often recalcitrant to medical therapy. these infections can potentially cause detrimental outcomes, in part due to a delay in diagnosis. we review 174 case reports and series on nontuberculous mycobacterial (ntm) ocular infections and discuss etiology, microbiology, risk factors, dia ... | 2015 | 26106601 |
| brain abscess following rituximab infusion in a patient with pemphigus vulgaris. | immunocompromised patients are at increased risk for developing meningitis or, rarely, brain abscess with opportunistic organisms like listeria monocytogenes. | 2015 | 25659437 |
| a nonhuman primate scrub typhus model: protective immune responses induced by pkarp47 dna vaccination in cynomolgus macaques. | we developed an intradermal (id) challenge cynomolgus macaque (macaca fascicularis) model of scrub typhus, the leading cause of treatable undifferentiated febrile illness in tropical asia, caused by the obligate intracellular bacterium, orientia tsutsugamushi. a well-characterized animal model is required for the development of clinically relevant diagnostic assays and evaluation of therapeutic agents and candidate vaccines. we investigated scrub typhus disease pathophysiology and evaluated two ... | 2015 | 25601925 |
| simultaneous detection of legionella species and l. anisa, l. bozemanii, l. longbeachae and l. micdadei using conserved primers and multiple probes in a multiplex real-time pcr assay. | legionnaires' disease is a severe respiratory disease that is estimated to cause between 8,000 and 18,000 hospitalizations each year, though the exact burden is unknown due to under-utilization of diagnostic testing. although legionella pneumophila is the most common species detected in clinical cases (80-90%), other species have also been reported to cause disease. however, little is known about legionnaires' disease caused by these non-pneumophila species. we designed a multiplex real-time pcr ... | 2016 | 27107536 |
| mechanistic insights into c-di-gmp-dependent control of the biofilm regulator fleq from pseudomonas aeruginosa. | bacterial biofilm formation during chronic infections confers increased fitness, antibiotic tolerance, and cytotoxicity. in many pathogens, the transition from a planktonic lifestyle to collaborative, sessile biofilms represents a regulated process orchestrated by the intracellular second-messenger c-di-gmp. a main effector for c-di-gmp signaling in the opportunistic pathogen pseudomonas aeruginosa is the transcription regulator fleq. fleq is a bacterial enhancer-binding protein (bebp) with a ce ... | 2016 | 26712005 |
| mechanistic insights into c-di-gmp-dependent control of the biofilm regulator fleq from pseudomonas aeruginosa. | bacterial biofilm formation during chronic infections confers increased fitness, antibiotic tolerance, and cytotoxicity. in many pathogens, the transition from a planktonic lifestyle to collaborative, sessile biofilms represents a regulated process orchestrated by the intracellular second-messenger c-di-gmp. a main effector for c-di-gmp signaling in the opportunistic pathogen pseudomonas aeruginosa is the transcription regulator fleq. fleq is a bacterial enhancer-binding protein (bebp) with a ce ... | 2016 | 26712005 |
| active and adaptive legionella crispr-cas reveals a recurrent challenge to the pathogen. | clustered regularly interspaced short palindromic repeats with crispr-associated gene (crispr-cas) systems are widely recognized as critical genome defense systems that protect microbes from external threats such as bacteriophage infection. several isolates of the intracellular pathogen legionella pneumophila possess multiple crispr-cas systems (type i-c, type i-f and type ii-b), yet the targets of these systems remain unknown. with the recent observation that at least one of these systems (ii-b ... | 2016 | 26936325 |
| determination of viable legionellae in engineered water systems: do we find what we are looking for? | in developed countries, legionellae are one of the most important water-based bacterial pathogens caused by management failure of engineered water systems. for routine surveillance of legionellae in engineered water systems and outbreak investigations, cultivation-based standard techniques are currently applied. however, in many cases culture-negative results are obtained despite the presence of viable legionellae, and clinical cases of legionellosis cannot be traced back to their respective con ... | 2016 | 26928563 |
| the legionella pneumophila incomplete phosphotransferase system (pts) is required for optimal intracellular growth and maximal expression of pmra regulated effectors. | the nitrogen phosphotransferase system (pts(ntr)) is a regulatory cascade present in many bacteria, where it controls different functions. this system is usually composed of three basic components: ei(ntr), npr and eiia(ntr) (encoded by the ptsp, ptso and ptsn genes, respectively). in legionella pneumophila, as well as in many other legionella species, the eiia(ntr) component is missing. however, we found that deletion mutations in both ptsp and ptso are partially attenuated for intracellular gr ... | 2017 | 28373357 |
| orange sputum in a kidney transplant patient with legionella micdadei pneumonia. | 2017 | 27133899 |