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follow-up study of individuals with untreated campylobacter pylori-associated gastritis and of noninfected persons with non-ulcer dyspepsia. 19883373024
[campylobacter pyloridis and its role in the development and clinical course of peptic ulcer and chronic erosive gastritis]. 19883373960
[campylobacter pyloridis in peptic ulcer].to study the role of campylobacter pyloridis (cp) in the etiology of peptic ulcer and chronic gastritis, biopsies were obtained from gastric and duodenal mucosa of 54 ulcer patients and 8 healthy controls. in normal histological appearance and moderate gastritis without signs of exacerbation cp were not registered contrary to atrophic antral gastritis demonstrating cp irrespective of ulcer location. cp resided on the epithelium under the mucous layer between epitheliocytes. contamination proved ...19883377694
[bismuth subsalicylate treatment in chronic campylobacter pylori-associated erosive gastritis].in a prospective open study 21 patients with upper abdominal complaints and chronic active gastritis as well as endoscopically proven erosions were treated with bismuth subsalicylate (4 x 30 ml/day, corresponding to 4 x 314 mg bi3+) for three weeks. in 20 patients (95%) campylobacter pylori (cp) was found in at least two of three examinations (culture, clo quick-test, special histology). after the treatment 17 of 21 patients (81%) were cp negative, and the clinical symptoms had gradually disappe ...19883378501
campylobacter pylori infection in patients undergoing endoscopy in tonga. 19883380454
are dyspeptic symptoms in patients with campylobacter pylori-associated type b gastritis linked to delayed gastric emptying?in this paper, the association of gastric campylobacter pylori (cp) colonization with histologic findings and gastric emptying of a mixed solid-liquid meal was prospectively investigated in 43 consecutive patients with essential non-ulcer dyspepsia (enud). gastric emptying was also measured in 30 symptom-free control subjects. the frequency of cp infection in patients with enud was 44.2%. we found a strong association between gastric cp colonization and chronic antral type b gastritis. although ...19883381805
rapid urease test (clo-test) for early detection of campylobacter pylori infection in children. 19883381813
failure of campylobacter pylori to grow in commercial blood culture systems.of 50 blood culture sets, 20 bacto (difco laboratories, detroit, mich.), 20 septi-chek (hoffmann-la roche, inc., nutley, n.j.), and 10 bactec 6b and 7d (johnston laboratories, inc., towson, md.) sets were inoculated with campylobacter pylori and fresh human blood. none of the 50 blood cultures produced any detectable growth. current commercial blood culture systems may be inadequate for the detection of c. pylori bacteremia.19883384893
characterization of urease from campylobacter pylori.campylobacter pylori, a suspected agent of gastritis and peptic ulceration, rapidly hydrolyzes urea. because urease serves as the basis of detection of the organism in gastric biopsies and may represent an important virulence factor, biochemical characteristics of the enzyme were determined. c. pylori was isolated from antral biopsies from 10 patients with complaints of abdominal pain or history of peptic ulcer disease. all isolates were urease positive, with an average rate of hydrolysis by cel ...19883384908
simple microbiologic detection of campylobacter pylori.a study of 84 gastric biopsies taken from 42 adult patients revealed simple techniques for gram stain and culture for campylobacter pylori. in an initial study of 18 biopsies, gram stains prepared from ground, diluted tissue were all negative for curved, gram-negative rods, whereas 13 of these specimens were positive for c. pylori by culture. the gram stains for the remaining 66 biopsies were prepared by a rinse-imprint technique. in this group, there were 30 gram stains positive for organisms r ...19883384915
cytopathic effects of campylobacter pylori urease. 19883384991
immunoblot analysis of immune response to campylobacter pylori and its clinical associations.systemic immune response to campylobacter pylori was detected by the immunoblot technique in serum samples from 200 patients, 129 blood donors, and 96 children. the results of the igg immunoblot test showed excellent correlation with the detection of c pylori by culture and also with histopathological examination of the antrum, as well as with peptic ulcer disease. an iga response also occurred and gave results comparable with those of the igg immunoblot test, although on a quantitatively lower ...19883384999
cytotoxic activity in broth-culture filtrates of campylobacter pylori.broth-culture filtrates of campylobacter pylori induced non-lethal cytopathic effects in vitro in 7 of 9 mammalian cell lines tested. transmission electronmicroscopy revealed that the response consisted of intracellular vacuolisation. intestine 407 cells were among the most responsive and were used for routine assay. about 55% of isolates of c. pylori tested, originating from four geographic regions worldwide, produced cytotoxic activity. the activity was neutralisable by specific antisera to br ...19883385767
distribution of campylobacter pylori in the human stomach obtained at postmortem.the distribution of campylobacter pylori, its prevalence, and its relationship to gastritis and urease activity have been studied in 54 postmortem stomachs. infection was confirmed by finding c. pylori in a gram-stained smear of gastric mucus harvested from the entire stomach. eight tissue specimens were obtained from predetermined sites from each stomach and examined for histologic gastritis and urease activity. thirty-seven per cent of stomachs were infected, and of these 80% had widespread hi ...19883387889
campylobacter pylori in peptic ulcer disease. iii. symptoms and paraclinical and epidemiologic findings.only a few publications have dealt with the subjective symptoms, the paraclinical findings, or the epidemiology in relation to cultivation of c. pylori. seventy-two patients answered a questionnaire containing questions about symptoms, dietary habits, smoking, and animal contact. c. pylori was cultivated from the biopsy specimens of 41 of these patients, and 31 were culture-negative. in addition, leukocyte count, differential count, and blood immunoglobulins were measured. in many culture-positi ...19883387900
prevalence of campylobacter pylori in an unselected swedish population of patients referred for gastroscopy.a survey of the prevalence of campylobacter pylori in an unselected series of 117 patients referred for gastroscopy showed that 49.6% of the patients were infected. in 87% of infected patients both the antrum and the body of the stomach were involved. duodenal infection occurred in only 9% of 102 studied patients. c. pylori could usually be demonstrated in mucosa showing signs of active chronic inflammation, whereas it was rarely found in histologically normal mucosa. the acridine orange stainin ...19883387901
campylobacter pylori and the gastric mucosa. 19883388166
evidence for proteolytic disruption of gastric mucus coat by campylobacter pylori. 19883388168
campylobacter pylori gastritis.campylobacter pylori colonisation of the stomach is strongly associated with type b non-autoimmune gastritis in adults. in a retrospective study of 38 gastric biopsy specimens taken during upper gastrointestinal endoscopy in children attending this hospital we found c pylori in nine (24%). ten biopsy specimens showed histological evidence of gastritis and c pylori was found in eight.19883389897
[campylobacter pylori and dyspeptic symptomatology]. 19883393716
antibody response of patients against a 120 kda surface protein of campylobacter pylori.campylobacter pylori strains were isolated and serum samples were obtained from 63 patients. immunoblots of 52 patients sera using their own isolates as antigen showed a 120 kda band, which was missing in the other 11 isolates and the respective sera. this band was not detected in other campylobacter species. effects of trypsin treatment of bacteria and absorption of sera by live organisms suggest a c. pylori-specific surface protein.19883394453
[diagnosis of campylobacter pylori gastritis. results of bacteriology and scanning electron microscopy]. 19883395055
[campylobacter pylori in gastric biopsies. comparison of biochemical and histological evidence and relation to chronic gastritis activity]. 19883396043
campylobacter pylori in a sample of finnish population: relations to morphology and functions of the gastric mucosa.the occurrence of campylobacter pylori (cp) was examined in 179 subjects representing a sample collected from the population of south finland. in a normal antral and body mucosa cp was present in 5% and 11% and in superficial gastritis (sg) in 71% and 91% of subjects, respectively. in atrophic gastritis (ag) of antrum and body the prevalence of cp decreased significantly with an increasing degree of atrophy, so that cp was not found in severe body ag. different combinations of antral and body ga ...19883396964
association of campylobacter pylori with gastritis, duodenal ulcer and gastric ulcer--a preliminary report of dyspeptic patients. 19883397134
detection of campylobacter pylori dna by hybridisation with non-radioactive probes in comparison with a 32p-labelled probe.a dot-blot hybridisation assay for the detection of campylobacter pylori was used to compare a 32p-labelled probe with two biotinylated probes and a sulphonated probe. the minimum amount of pure c. pylori dna that could be detected by the 32p-labelled probe was 100 pg, which corresponded to 5 x 10(4) bacteria. a biotin-labelled dna (biotin-dna) probe together with the blugenetm detection system produced by bethesda research laboratories (brl), and a sulphonated probe and chemiprobetm detection s ...19883398032
[campylobacter pylori and peptic ulcer]. 19883398812
campylobacter pylori--a simple answer to a complex problem? 19883399180
evidence for weakening of gastric mucus integrity by campylobacter pylori.the role of campylobacter pylori in weakening the mucus component of the gastric mucosal barrier was investigated. the extracellular material elaborated by c. pylori, cultured from antral mucosal biopsy specimens of patients undergoing gastroscopy, caused a rapid degradation of mucus glycoprotein polymer to glycopeptides comparable in size to those produced by the action of pepsin. viscosity measurements showed that incubation of c. pylori filtrate with gastric mucus led to a gradual loss in muc ...19883399831
[detection of campylobacter pylori in gastric mucosa biopsies]. 19883402345
susceptibility of clinical isolates of campylobacter pylori to 24 antimicrobial and anti-ulcer agents.forty-nine isolates of campylobacter pylori were tested for their susceptibility to twenty antibiotics and four anti-ulcer agents by an agar dilution technique. penicillin and amoxycillin were the most active drugs (mic90, 0.06 microgram/ml); erythromycin, cefazolin, minocycline, ciprofloxacin, ofloxacin and gentamicin were slightly less active (mic90, less than or equal to 1 microgram/ml). moderate activity was found for doxycyclin, rifampin, nitrofurantoin, norfloxacin, pefloxacin, enoxacin, p ...19883402574
[clinical significance of elisa for campylobacter pylori]. 19883404760
antibody response to campylobacter pylori in diverse ethnic groups.antibody response to campylobacter pylori was measured in ethnic groups of vietnamese, el salvadorean and ethiopian origin. the results were compared with the previously reported antibody titres found in sera of culture positive and culture negative patients, patients suffering from duodenal ulcer, white australian blood donors and australian aboriginals. while in vietnamese the prevalence of serologically positive sera was found to be similar to the white australian population, numbers of serol ...19883406677
mannose-resistant haemagglutination by campylobacter pylori.10 campylobacter pylori strains were screened for the presence of presumptive colonization factors by measuring cell surface hydrophobicity and haemagglutination. all 8 clinical isolates and 2 reference strains caused haemagglutination of rabbit, human and/or sheep erythrocytes in the presence of mannose. none of the strains expressed a hydrophobic cell surface. in preliminary experiments the haemagglutination could be inhibited with monosialogangliosides suggesting that these strains express si ...19883406678
antibody titres to campylobacter pylori after treatment for gastritis. 19883408982
symptoms due to campylobacter pylori. 19883410233
evaluation of a rapid urease test to detect campylobacter pylori infection.seventy-five consecutive patients referred for upper gastrointestinal tract endoscopy were evaluated for campylobacter pylori infection by pathology, culture, and a biochemical test to detect bacterial urease. forty-eight patients (64%) had c. pylori present based on pathology or culture or both. thirty-two urease tests were positive after 1 h, all in patients with c. pylori detected by the two other methods (specificity, 100%; sensitivity, 67%). after 24 h, 47 urease tests were positive, but on ...19883410949
urease tests for campylobacter pylori: care in interpretation. 19883410977
iatrogenic campylobacter pylori infection is a cause of epidemic achlorhydria.on a number of occasions, there have been descriptions of epidemic achlorhydria in subjects undergoing repeated gastric secretory studies, typically as part of research protocols. we observed a case in a 37-yr-old healthy man undergoing weekly gastric analyses, along with endoscopy and gastric biopsy, as part of a research protocol studying gastric adaptation to aspirin. in the middle of the 2nd wk of aspirin administration, he developed severe nausea and epigastric discomfort. aspirin administr ...19883414650
[campylobacter pylori and gastric mucosa]. 19883417084
[titration of anti-campylobacter pylori by elisa]. 19883417085
[preparation of anti-campylobacter pylori monoclonal antibodies]. 19883418938
acute presentation of campylobacter pylori gastritis.a 46-yr-old male was admitted to hospital with profuse vomiting, epigastric pain, and an infiltrative gastric lesion. evidence is presented supporting the proposition that the symptoms were the product of an acute inflammatory response in the stomach induced by the bacterium campylobacter pylori. the progress of the patient was monitored over a 2-yr period by endoscopic examination and serology for c. pylori. a significant rise in igg antibody to c. pylori was seen only at 14 wk.19883421230
campylobacter pylori in gastroduodenal diseases: current views--future directions. proceedings of an international workshop. copenhagen, 15 and 16 october 1987. 19883166526
monotherapy or polychemotherapy in the treatment of campylobacter pylori-related gastroduodenal disease.three pilot studies were performed to evaluate the efficacy of bismuth subsalicylate (bss) and nitrofurantoin to eradicate campylobacter pylori colonization in man. nitrofurantoin 3 x 100 mg capsules for 10 days did not clear c. pylori in any of 13 patients, and neither did the combination of bss and nitrofurantoin suspension (0/6 patients). immediately after high dose bss therapy 3 x 900 mg for 28 days, 8/17 patients (47%) had negative cultures and rapid urease tests. there was recrudescence in ...19883166527
natural sources and microbiological characteristics of campylobacter pylori. 19883166529
histological aspects of campylobacter pylori colonisation and infection of gastric and duodenal mucosa.the main features of the histopathology of campylobacter pylori-associated gastritis are reviewed. the organism is strongly associated with the type b pattern of chronic gastritis. it colonizes the abnormal antrum and is not usually seen on the normal mucosa. however it fails to colonize the abnormal antrum in the type a gastritis of pernicious anaemia. when present in the duodenum it is in conjunction with severe duodenitis and gastric metaplasia. although the organisms are present in over 70% ...19883166530
pathogenetic implications of ultrastructural findings in campylobacter pylori related gastroduodenal disease.there is now substantial evidence that campylobacter pylori (cp) is able to colonize the gastroduodenal mucosa and is responsible for active chronic gastritis, its role in duodenitis, gastric ulceration and duodenal ulceration is still under debate. cp has a lot of characteristics which are prerequisites for a pathogen: the typical s-shape, the corkscrew-like movement and the powerful urease and protease enzymes. these features allow a rapid movement through the mucous layer to permit access to ...19883166531
possible pathogenetic pathways of campylobacter pylori in gastro-duodenal disease.the exact pathogenic mechanisms involved in campylobacter pylori associated gastro-duodenal inflammation are unclear. c. pylori adheres to gastric type epithelium and colonisation is associated with a number of ultrastructural abnormalities. other factors thought important include the marked bacterial urease activity, enzymatic degradation of the mucous layer and possible toxins. the induced inflammatory reaction will also contribute to tissue damage and a breakdown of normal defense mechanisms.19883166532
immune response of the gastric mucosa to campylobacter pylori.the histological features of non-autoimmune chronic gastritis are consistent with those of a local immune response by the gastric mucosa. if campylobacter pylori is causative in this condition, then the immune response will be in part specific for this organism. antibodies to c. pylori are present in the gastric juice of infected patients. coating of mucosal c. pylori by antibody in vivo can be demonstrated by immunohistochemistry, and a neutrophil infiltrate (active gastritis) is associated wit ...19883166533
an enzyme-linked immunosorbent assay for the serodiagnosis of campylobacter pylori-associated gastritis.an elisa system, using an acid extractable cell surface c. pylori antigen, has been used to detect anti-c. pylori antibodies in 176 endoscoped patients. the antibody concentration was related to histological diagnosis and colonisation with campylobacter-like organisms. the criteria for sero-positivity was determined from the median antibody concentration in a group of 368 non-endoscoped control patients. the specificity and sensitivity of the sero-diagnostic assay for histological gastritis in a ...19883166534
prevalence of campylobacter pylori in duodenal and gastric mucosa--relationship to inflammation.endoscopic biopsies from 310 patients were studied for the presence of campylobacter pylori (cp). in the first group of 150 patients duodenal and antral biopsies were obtained and in the second (160 patients) biopsies were taken from various sites in the stomach including the antrum, incisura, body and fundus. in the duodenum there was a strong association with active inflammation and the presence of gastric metaplasia. cp were never seen in the normal duodenum. in the stomach cp presence was as ...19883166535
the efficacy of antimicrobial treatment in campylobacter pylori-associated gastritis and duodenal ulcer.the efficacy of various antimicrobial and anti-ulcer agents on the elimination of campylobacter pylori in duodenal ulcer patients was investigated. ranitidine, cimetidine, pirenzepine, aluminium phosphate gel as well as combinations of h2-receptor antagonists or pirenzepine + penicillin v, ciprofloxacin, ofloxacin, phenyl-mercuryborate or rifampicin had no influence on c. pylori in vivo. short term elimination of c. pylori was achieved in 3/15 patients treated with ranitidine + bacampicillin and ...19883166537
chronic erosive gastritis--a therapeutic approach with bismuth.37 patients with epigastric pain and chronic erosive gastritis underwent an open controlled therapeutic trial with bismuthsubsalicylate (bs). group a (21 patients) was treated with bs, liquid, 4 x 314 mg for three weeks, group b (16 patients) with bs tablets, 3 x 300 mg for two weeks. a significant reduction of symptoms (p less than 0.001) and endoscopically assessed chronic erosions (p less than 0.001) was achieved in both groups. campylobacter pylori was detected in 89% of the patients before ...19883166538
epidemiology of campylobacter pylori infection: ethnic considerations.a proper perspective of the association of campylobacter pylori with various diseases can be achieved only when the incidence of c. pylori infection in the normal population is known. we used the 13c urea breath test (a simple, specific, noninvasive, safe, and reproducible method to assess the presence of active c. pylori infection) to compare the frequency of c. pylori infection in healthy young adults from three areas of the world. we studied 26 women and 32 men (ages 20 to 29): 29 from the un ...19883166539
pharmacokinetic, bacteriological and clinical aspects on the use of doxycycline in patients with active duodenal ulcer associated with campylobacter pylori.seven patients with active duodenal ulcer and positive cultures for campylobacter pylori were given anti-ulcer treatment for 28 days with the addition of doxycycline for the last nine days. repeated endoscopy with biopsy for culture and doxycycline concentration determinations from the mucosa at the end of doxycycline therapy showed that five of seven patients remained positive in culture. the concentrations of doxycycline in biopsy material were 0.1 to 0.3 mg/kg in four patients; in three patie ...19883166544
campylobacter pylori in upper gastrointestinal disease. 19883167290
distribution of campylobacter pylori in dyspeptic and non-dyspeptic gastroenterologic patients.the presence of campylobacter pylori (cp) in antral biopsies from patients undergoing routine gastroscopy or ercp was determined by microbiological and histological methods and correlated to the histopathology. 322 endoscopies were performed. of 125 cp positives only one did not present with histopathological evidence of gastritis. in patients with gastritis the percentage positive for cp was highest (88.6) in severe gastritis. we also found a highly significant correlation of cp to all types of ...19883168555
[drug therapy of campylobacter pylori-associated gastritis]. 19883168772
relationship between campylobacter pylori and gastritis in healthy humans after administration of placebo or indomethacin.endoscopic and microscopic appearances of antral and fundic mucosa were correlated with the presence or absence of campylobacter pylori--and with plasma immunoglobulin g antibodies to that organism--in 23 healthy volunteers, 12 of whom had received indomethacin and 11 of whom had received no medication. antral c. pylori, found in 9 of 23 biopsy specimens (3 of 11 controls, 6 of 12 indomethacin-treated patients; not significantly different), correlated strongly with histologic evidence of active ...19883169487
isolation of a spiral-shaped bacterium from the cat stomach.a spiral- or helix-shaped bacterium that colonizes the stomachs of cats has been isolated in pure culture for the first time. the organism is tightly coiled with tufts of 10 to 17 polar flagella positioned slightly off center at the end of the cell. the body of the cell is entwined with unique periplasmic fibrils that usually occur in pairs, although groupings of one and three fibrils were also seen. the organism is strongly urease, catalase, and oxidase positive and is likely to belong to an as ...19883169989
gastric colonization by campylobacter pylori subsp. mustelae in ferrets.campylobacter pylori subsp. mustelae was cultured from both normal and inflamed gastric mucosa of ferrets. examination of neonatal, juvenile, and adult ferrets established that the gastric mucosa in the majority of preweanling (age, less than 6 weeks) ferrets sampled were not colonized with c. pylori subsp. mustelae, whereas the gastric mucosa of 100% of adult ferrets were colonized with this gastric organism. c. pylori subsp. mustelae was isolated from the gastric mucosa on a sequential basis f ...19883169994
failure of ciprofloxacin to eradicate campylobacter pylori from the stomach. 19883170399
the urease enzymes of campylobacter pylori and a related bacterium.the urease enzyme of campylobacter pylori was studied and compared with that of a related spiral-shaped bacterium, st1, isolated from the rodent ileum. both bacteria possessed constitutive urease enzymes with activities up to 20-70 times that of proteus vulgaris. this activity was retained on sds-polyacrylamide gels. a major catalytic subunit of mol. wt 300,000 was located for all (six) strains of c. pylori subjected to sds-page whereas st1 had two active forms of mol. wts 140,000 and 150,000. w ...19883172169
isolation of a gastric campylobacter-like organism from the stomach of four rhesus monkeys, and identification as campylobacter pylori.campylobacter-like organisms, isolated from the gastric antrum of rhesus monkeys, were compared with campylobacter jejuni and c. pylori. they were similar to c. pylori by light microscopy, in ultrastructural morphology, in enzymic, fatty-acid-methyl-ester, and protein-profile analysis, and in antigenic reactivity with rabbit antisera to c. jejuni and c. pylori and with c. pylori-specific monoclonal antibody. because this natural infection of the rhesus monkey is associated with chronic gastritis ...19883172170
immunoblot fingerprinting of campylobacter pylori.one hundred and fifty isolates of campylobacter pylori were divided into nine groups by immunoblot fingerprinting. all isolates were typable and reproducibility between immunoblots was good provided both antigen and antibody preparation were standardised. discrimination was a problem as groups 1 and 2 accounted for 66% of isolates. recurrence after bismuth treatment was due to indistinguishable strains in five patients and different strains in three patients.19883172174
[relation between chronic antral gastritis and the presence of campylobacter pyloridis. retrospective study on a geriatric population]. 19883173758
[campylobacter pylori and gastric mucosa. what method to use in the diagnosis?]. 19883175273
na+/h+ ion-exchange property of postmortem human gastric mucus.the na+/h+ ion-exchange property of human gastric mucus and its relationship to age has been studied. mucus was collected from 40 postmortem human stomachs (age range, 21-83 years) within 24 h of traumatic death. twenty-one stomachs (age range, 21-76 years) were free of campylobacter pylori infection and histologic gastritis. mucus from these stomachs was consistently a cation exchanger at ph 6 in an in vitro system. the cation-exchange capacity of mucus from seven stomachs within the age range ...19883175531
campylobacter pylori in peptic ulcer disease. ii. endoscopic findings and cultivation of c. pylori.specimens from 153 consecutive patients were cultivated for c. pylori, and findings were correlated to the endoscopic findings. c. pylori was cultivated more frequently from males than from females. culture-positive males had a high frequency of prepyloric abnormalities. no correlation between age or ph in gastric juice and cultivation of c. pylori was found. c. pylori was found significantly more often in patients with peptic ulcer and/or duodenitis than in patients with normal endoscopic findi ...19883175537
campylobacter pylori--associated gastritis and peptic ulcer disease in children.specimens obtained at gastric biopsies performed for suspected acid peptic disease in patients 5 through 17 years of age were retrospectively reviewed for the presence of campylobacter pylori (cp), a gram-negative bacillus associated with chronic gastritis and peptic ulcer disease in adults. of 98 patients who underwent antral biopsy (the most reliably colonized site in the stomach), 40 had chronic gastritis histologically. of those 40 patients, 22 (55%) had cp present on the gastric surface. no ...19883177319
[campylobacter pylori, ulcer and dyspepsia]. 19883181030
is transmission of campylobacter pylori by endoscopic examination possible? 19883181090
the characterization and pathological significance of gastric campylobacter-like organisms in the ferret: a model for chronic gastritis?gastric campylobacter-like organisms (clo) were isolated from gastric tissues removed at sacrifice from 17 mature ferrets; all animals were colonized, but no macroscopic mucosal lesions or histological features of chronic gastritis were seen. the isolates resembled campylobacter pylori in many cultural and biochemical characteristics, and produced substantial urease activity, but there were sufficient differences from c. pylori to suggest that ferret gastric clo represents a separate species. co ...19883181311
gastric acid secretion and campylobacter pylori. 19883181692
effects of antibacterial treatment of campylobacter pylori-associated gastritis in children. 19883181694
in vitro model for campylobacter pylori adherence properties.the adherence of 12 strains of campylobacter pylori was studied on four cell lines. immunofluorescence and scanning and transmission electron microscopy were used to visualize the bacteria. a heavy adherence to the epithelial cell line hep-2 and to the intestinal cell line int-407 was noted. by transmission electron microscopy, a close association between bacteria and cells in the form of cup-like structures was observed, but pedestals were not present.19883182085
campylobacter pylori: what is it doing there? 19883182639
campylobacter pylori isolated from the stomach of the monkey, macaca nemestrina.campylobacter pylori was isolated from the gastric mucosa in 6 of 24 pigtailed macaques (macaca nemestrina) examined by gastric biopsy and culture; 3 isolates were recovered during gastroendoscopy, and 3 were recovered at necropsy. the isolates were morphologically and biochemically similar to the human type strain nctc 11638, differing only in colony diameter, pigmentation, and rate of growth. identity of the isolates was confirmed by whole-genomic dna-dna hybridization with the type strain. co ...19883183019
treatment of campylobacter pylori-associated antral gastritis in children with bismuth subsalicylate and ampicillin.we evaluated the efficacy of medical therapy, consisting of liquid bismuth subsalicylate prescribed either in combination with oral ampicillin (n = 15) or alone (n = 1), in the clearing of bacterial colonization on the antrum in 16 children with campylobacter pylori-associated antral gastritis. we also examined the effects of medical treatment on altering the severity of associated antral inflammation. eight patients had upper gastrointestinal tract hemorrhage, two had acute gastric outlet obstr ...19883183851
[campylobacter pylori colonization of duodenal and gastric mucosa in duodenitis and duodenal ulcer]. 19883185416
[campylobacter pyloridis in chronic gastritis and peptic ulcer]. 19883187687
[campylobacter pylori. a causative agent of gastritis and ulcer disease or a commonly associated agent?]. 19883188413
campylobacter pylori infection. 19883190047
incidence of campylobacter pylori in patients with upper gastro-intestinal symptoms.antral mucosal biopsy specimens were examined microbiologically and histologically for the presence of campylobacter pylori in 224 patients with upper gastrointestinal symptoms. the gastric mucosa of 183 patients (82%) were found to harbour c. pylori. c. pylori was strongly associated with the presence of histological gastritis (93%) and was detected in only 10% of 30 patients in whom histological examination of gastric biopsy specimens was negative. endoscopically diagnosed duodenal lesions wer ...19883194804
prevalence of gastric metaplasia, inflammation, and campylobacter pylori in the duodenum of members of a normal population.mucosal biopsies were obtained from 116 asymptomatic volunteers (50% were male; mean age, 46 years; age range, 19-91 years) to study the prevalence of duodenal gastric metaplasia (gm) and its association with inflammation and campylobacter pylori in a normal population. gm was identified in 25 subjects (22%). eighty-three subjects (72%) had histologic duodenitis, but in only 10 did the infiltrate include neutrophils (grade 2 duodenitis). c. pylori was found in the stomach in 36 subjects (31%), a ...19883195501
distribution of campylobacter pylori and gastritis in the stomach of patients with and without duodenal ulcer.the presence of campylobacter pylori and histological changes of gastric mucosa were studied in 50 consecutive patients with gastric complaints. c. pylori was isolated from the antrum, body, and fundus of 40 patients with (n = 20) and without (n = 20) duodenal ulcer. the incidence of gastritis was not significantly different in the antrum of c. pylori-positive patients with and without ulcer. otherwise, oxyntic mucosa of both body and fundus regions exhibited gastritis in 64.1% of the c. pylori- ...19883195542
campylobacter pylori in families of children with relapsing gastroduodenal disease due to c. pylori infection. 19883195559
campylobacter pylori--gastroduodenal pathogen or opportunistic bystander? 19883196241
campylobacter pylori, resistant duodenal ulcers, and antibiotic treatment. 19883199281
campylobacter pylori and barrett's esophagus.campylobacter pylori is thought to be confined to gastric mucosa; when detected in the duodenum in association with duodenal ulceration, the organism infects only areas of gastric metaplasia. barrett's esophagus is a metaplastic condition of the esophagus, in which areas or islands of "gastric-type" epithelium are found. to determine whether c. pylori colonized the esophagus of patients with barrett's esophagus, we studied retrospectively 23 unselected patients who had endoscopic and biopsy evid ...19883199885
campylobacter pylori and barrett's esophagus.occurrence of c. pylori infection of mucosa outside of the stomach might provide an ideal opportunity to examine c. pylori-mucosal interactions apart from the effects of acid and pepsin. techniques previously used to examine barrett's epithelium (for example, special mucin stains or scanning and transmission electron microscopy) might be particularly useful for exploration of new associations and formulation of new hypotheses. whether c. pylori has a role in development of barrett's ulcer or ade ...19883199889
the use of serology to diagnose active campylobacter pylori infection.a serological test that predicts accurately active campylobacter pylori infection in the human stomach has been developed and validated by means of serum from 189 patients who were undergoing endoscopy in sydney. our enzyme-linked immunosorbent assay (elisa) has a sensitivity of 100% and a specificity of 94%. an important part of the test is the inclusion of a simple absorption step with c. jejuni for those sera whose results are close to the cut-off point for positivity. this has been shown to ...19883200186
[campylobacter pylori colonization and gastroduodenal pathology].355 patients suffering from dyspepsia with an endoscopic pathological picture were examined. campylobacter pylori was sought histologically and by culture. histological and cultural results were compared. there were no bacteria on the gastric mucosa of 46 patients who had no histopathological evidence of lesions. cultural studies were performed in 40 cases on endoscopic instruments used during the examination, before and after standard sterilization. campylobacter pylori was found on the gastric ...19883200472
susceptibility of campylobacter pylori to macrolides and fluoroquinolones.the in-vitro activities of several 14-, 15- and 16-membered macrolides and fluoroquinolones against campylobacter pylori were determined. in general, 14-membered macrolides, such as clarithromycin and flurithromycin, were more active than the 15-membered macrolide, azithromycin, which was more active than 16-membered macrolides, such as miocamycin and rokitamycin. fluoroquinolones, except ciprofloxacin and a-61827, were less active than macrolides. clarithromycin was the most active of the new c ...19883209524
inhibitory antimicrobial concentrations against campylobacter pylori in gastric mucosa.gastric mucosal concentrations of erythromycin, amoxycillin, ampicillin and ciprofloxacin were determined in patients at upper gastrointestinal endoscopy 38-480 min after a 500 mg dose of erythromycin ethyl succinate, erythromycin stearate, amoxycillin, pivampicillin or ciprofloxacin. all the agents attained concentrations greater than the mic 90 for campylobacter pylori. the macrolides attained the lowest concentrations. there was no significant difference between concentrations attained with e ...19883209531
[campylobacter pylori, chronic gastritis and ulcer disease]. 19883217644
[campylobacter pylori in chronic gastritis and the therapeutic efficacy of colloidal bismuthate]. 19883219933
[antibiotics in the treatment of intractable duodenal ulcer disease complicated by campylobacter pylori infection]. 19883219934
[campylobacter pylori in asymptomatic volunteers]. 19883219935
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