Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| role of clinicogenomics in infectious disease diagnostics and public health microbiology. | clinicogenomics is the exploitation of genome sequence data for diagnostic, therapeutic, and public health purposes. central to this field is the high-throughput dna sequencing of genomes and metagenomes. the role of clinicogenomics in infectious disease diagnostics and public health microbiology was the topic of discussion during a recent symposium (session 161) presented at the 115th general meeting of the american society for microbiology that was held in new orleans, la. what follows is a co ... | 2016 | 26912755 |
| the role of il-23, il-22, and il-18 in campylobacter jejuni infection of conventional infant mice. | we have recently shown that, within 1 week following peroral campylobacter jejuni infection, conventional infant mice develop self-limiting enteritis. we here investigated the role of il-23, il-22, and il-18 during c. jejuni strain 81-176 infection of infant mice. the pathogen efficiently colonized the intestines of il-18(-/-) mice only, but did not translocate to extra-intestinal compartments. at day 13 postinfection (p.i.), il-22(-/-) mice displayed lower colonic epithelial apoptotic cell numb ... | 2016 | 27429795 |
| campylobacter concisus utilizes blood but not short chain fatty acids despite showing associations with firmicutes taxa. | campylobacter concisus is a member of the oral microbiota that has been associated with the development of inflammatory bowel diseases. however, the role of the bacterium in disease aetiology remains poorly understood. here, we examine optimal conditions for the growth of c. concisus, and the pathogenic potential of this bacterium in human gastrointestinal cells from the upper tract. further, the presence of c. concisus in the lower tract of crohn's disease (cd) patients undergoing therapy is ob ... | 2016 | 27339421 |
| campylobacter concisus pathotypes are present at significant levels in patients with gastroenteritis. | given that campylobacter jejuni is recognized as the most common cause of bacterial gastroenteritis worldwide, recent findings showing comparable levels of campylobacter concisus in patients with gastroenteritis would suggest that this bacterium is clinically important. the prevalence and abundance of campylobacter concisus in stool samples collected from patients with acute gastroenteritis was examined using quantitative real-time pcr. the associated virulence determinants exotoxin 9 and zonula ... | 2016 | 26698172 |
| immunoglobulin g response in patients with campylobacter concisus diarrhea. | limited information is available on the systemic immunoglobulin response in patients infected with the emerging pathogen campylobacter concisus. the aim of the present study was to detect anti-c. concisus antibodies in serum of 88 patients with c. concisus gastroenteritis. specific igg antibodies to c. concisus were measured in serum using an in-house enzyme-linked immunosorbent assay, and pooled donor serum was used as a control. the mean optical density was 0.135 (sem: 0.020) for the 88 adult ... | 2016 | 26643061 |
| tlr4, nod1 and nod2 mediate immune recognition of putative newly identified periodontal pathogens. | periodontitis is a polymicrobial inflammatory disease that results from the interaction between the oral microbiota and the host immunity. although the innate immune response is important for disease initiation and progression, the innate immune receptors that recognize both classical and putative periodontal pathogens that elicit an immune response have not been elucidated. by using the human oral microbe identification microarray (homim), we identified multiple predominant oral bacterial speci ... | 2016 | 26177212 |
| genome analysis of campylobacter concisus strains from patients with inflammatory bowel disease and gastroenteritis provides new insights into pathogenicity. | campylobacter concisus is an oral bacterium that is associated with inflammatory bowel disease. c. concisus has two major genomospecies, which appear to have different enteric pathogenic potential. currently, no studies have compared the genomes of c. concisus strains from different genomospecies. in this study, a comparative genome analysis of 36 c. concisus strains was conducted including 27 c. concisus strains sequenced in this study and nine publically available c. concisus genomes. the c. c ... | 2016 | 27910936 |
| [study of mutual dependence of periodontal and colonic microbiome in health and pathology using nsg-sequencing]. | by using ngs-sequencing libraries of dna from periodontal swabs with primers specific to v6 region of 16s rdna prevalence of bacterial genera and species in periodontal and colonic microbiota of patients with periodontitis of different severity and healthy donors was analyzed. hyper-colonization of the colon with akkermansia muciniphila was found to be the most important maker of negative predisposition to periodontitis (t=133,7 at р=10(-6)). this result is in a good agreement with communication ... | 2016 | 27239990 |
| azathioprine, mercaptopurine, and 5-aminosalicylic acid affect the growth of ibd-associated campylobacter species and other enteric microbes. | campylobacter concisus is a bacterium that is associated with inflammatory bowel disease (ibd). immunosuppressive drugs including azathioprine (aza) and mercaptopurine (mp), and anti-inflammatory drug such as 5-aminosalicylic acid (5-asa) are commonly used to treat patients with ibd. this study aimed to examine the effects of aza, mp, and 5-asa on the growth of ibd-associated bacterial species and to identify bacterial enzymes involved in immunosuppressive drug metabolism. a total of 15 bacteria ... | 2017 | 28424670 |
| incidence of campylobacter concisus and c. ureolyticus in traveler's diarrhea cases and asymptomatic controls in nepal and thailand. | campylobacter concisus and c. ureolyticus have emerged in recent years as being associated with acute and prolonged gastroenteritis and implicated in the development of inflammatory bowel diseases. however, there are limited data on the prevalence of these microorganisms in southeast asia. in this study, 214 pathogen-negative stool samples after laboratory examination for common enteric pathogens to include c. jejuni and c. coli by culture from two case-control traveler's diarrhea (td) studies c ... | 2017 | 28824712 |
| campylobacter concisus genomospecies 2 is better adapted to the human gastrointestinal tract as compared with campylobacter concisus genomospecies 1. | campylobacter concisus was previously shown to be associated with inflammatory bowel disease including crohn's disease (cd) and ulcerative colitis (uc). c. concisus has two genomospecies (gs). this study systematically examined the colonization of gs1 and gs2 c. concisus in the human gastrointestinal tract. gs1 and gs2 specific polymorphisms in 23s rrna gene were identified by comparison of the 23s rrna genes of 49 c. concisus strains. two newly designed pcr methods, based on the polymorphisms o ... | 2017 | 28824443 |
| complete genome sequence of campylobacter concisus atcc 33237(t) and draft genome sequences for an additional eight well-characterized c. concisus strains. | we report the complete genome sequence of the campylobacter concisus type strain atcc 33237 and the draft genome sequences of eight additional well-characterized c. concisus strains. c. concisus has been shown to be a genetically heterogeneous species, and these nine genomes provide valuable information regarding the diversity within this taxon. | 2017 | 28729281 |
| analysis of a dual domain phosphoglycosyl transferase reveals a ping-pong mechanism with a covalent enzyme intermediate. | phosphoglycosyl transferases (pgts) are integral membrane proteins with diverse architectures that catalyze the formation of polyprenol diphosphate-linked glycans via phosphosugar transfer from a nucleotide diphosphate-sugar to a polyprenol phosphate. there are two pgt superfamilies that differ significantly in overall structure and topology. the polytopic pgt superfamily, represented by mray and weca, has been the subject of many studies because of its roles in peptidoglycan and o-antigen biosy ... | 2017 | 28630348 |
| campylobacter concisus as the etiologic agent of gastrointestinal diseases. | a number of reports on the pathogenic influence of campylobacter concisus on the human body and its role in many diseases of the gastrointestinal system, including gastroesophageal reflux disease, barrett's esophagus and inflammatory bowel disease, have appeared lately. campylobacter concisus is a gram negative bacteria which requires an anaerobic environment or microaerophilic environment with hydrogen for growth and is therefore difficult to culture. due to this difficulty, the rate of infecti ... | 2017 | 28397447 |
| unsupervised statistical discovery of spaced motifs in prokaryotic genomes. | dna sequences contain repetitive motifs which have various functions in the physiology of the organism. a number of methods have been developed for discovery of such sequence motifs with a primary focus on detection of regulatory motifs and particularly transcription factor binding sites. most motif-finding methods apply probabilistic models to detect motifs characterized by unusually high number of copies of the motif in the analyzed sequences. | 2017 | 28056763 |
| erratum: genome analysis of campylobacter concisus strains from patients with inflammatory bowel disease and gastroenteritis provides new insights into pathogenicity. | 2017 | 28205571 | |
| motility of campylobacter concisus isolated from saliva, feces, and gut mucosal biopsies. | campylobacter concisus is an emerging pathogen associated with gastrointestinal disorders such as gastroenteritis and inflammatory bowel diseases (ibd), but the species is also found in healthy subjects. the heterogeneous genome of c. concisus increases the likelihood of varying virulence between strains. flagella motility is a crucial virulence factor for the well-recognized campylobacter jejuni; therefore, this study aimed to analyze the motility of c. concisus isolated from saliva, gut biopsi ... | 2017 | 28116789 |
| the consequences of campylobacter infection. | the purpose of this review is to provide an update on the clinical, public health and economic consequences of campylobacter infection. | 2017 | 27798443 |