Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| detection of epstein-barr virus and kaposi's sarcoma-associated herpesvirus dna in csf from persons infected with hiv who had neurological disease. | to determine the frequency and clinical relevance of epstein-barr virus (ebv) and kaposi's sarcoma associated herpesvirus (kshv) dna detection in the csf from patients infected with hiv. | 1998 | 9703169 |
| emerging viruses in blood transfusion. | 1998 | 9704434 | |
| overview of the epidemiology of immunodeficiency-associated cancers. | immunodeficiency, be it congenital, therapeutic, or infectious in origin, increases the risk of certain, but not all, types of cancer. a common feature of these cancers is that specific infectious agents appear to be important in their etiology, not only in immunodeficient subjects but also in the general population. people with acquired immunodeficiency syndrome (aids) are at an increased risk of kaposi's sarcoma, non-hodgkin's lymphoma, hodgkin's disease, squamous cell carcinoma of the conjunc ... | 1998 | 9709294 |
| cancers in human immunodeficiency virus-infected children. | although the exact incidence of cancers in human immunodeficiency virus (hiv)-infected children is not clear, an excess of non-hodgkin's lymphomas and soft tissue tumors as well as a multitude of otherwise rare tumors in childhood, such as cervical, thyroid, or pulmonary carcinoma, has been reported. in contrast to the findings in hiv-infected adults, kaposi's sarcoma is rare in children in industrialized countries but not in children living in the sub-saharan area. treatment of the neoplastic d ... | 1998 | 9709300 |
| kaposi's sarcoma-associated herpesvirus-encoded oncogenes and oncogenesis. | molecular biologic studies of kaposi's sarcoma-associated herpesvirus (kshv) have identified a number of potential viral oncogenes that may contribute to kshv-related neoplasia including a d-type cyclin, an il-6-like cytokine, and a novel member of the interferon regulatory factor family. kshv is functionally related to other dna tumor viruses by encoding specific proteins to inhibit prb, pro-apoptotic, and interferon-signaling tumor suppressor pathways. the virus appears to employ molecular pir ... | 1998 | 9709306 |
| kaposi's sarcoma-associated herpesvirus. | kaposi's sarcoma (ks) is a vascular tumor predominantly found in the immunosuppressed. epidemiologic studies suggest that an infective agent is the etiologic culprit. kaposi's sarcoma-associated herpesvirus (kshv), or human herpesvirus-8 (hhv-8), is a gamma human herpesvirus present in all epidemiologic forms of ks and also in a rare type of a b cell lymphoma, primary effusion lymphoma (pel). in addition, this virus is present in most biopsies from human immunodeficiency virus (hiv)-associated m ... | 1998 | 9709807 |
| identification of an immunoreceptor tyrosine-based activation motif of k1 transforming protein of kaposi's sarcoma-associated herpesvirus. | kaposi's sarcoma-associated herpesvirus (kshv) is consistently identified in kaposi's sarcoma and body cavity-based lymphoma. kshv encodes a transforming protein called k1 which is structurally similar to lymphocyte receptors. we have found that a highly conserved region of the cytoplasmic domain of k1 resembles the sequence of immunoreceptor tyrosine-based activation motifs (itams). to demonstrate the signal-transducing activity of k1, we constructed a chimeric protein in which the cytoplasmic ... | 1998 | 9710606 |
| absence of hhv-8 dna sequences in malignant mesothelioma. | human herpesvirus 8 (hhv-8) associated primary effusion lymphomas arise and grow in the body cavities as effusions, but it is not known whether the lining of body cavities and mesothelium derived malignancies are potential targets of hhv-8 infection. we examined a series of 13 diffuse malignant mesotheliomas and four mesothelial cell rich effusion samples of non-neoplastic aetiology from non-immunodepressed patients using the polymerase chain reaction to detect hhv-8 specific sequences. hhv-8 am ... | 1998 | 9713597 |
| kaposi's sarcoma-associated herpesvirus (kshv) in bone marrow biopsies of patients with waldenstrom's macroglobulinaemia. | kaposi's sarcoma-associated herpesvirus (kshv) is suspected to play a role in the aetiology of multiple myeloma. because of similarities in the pathophysiology of multiple myeloma and waldenstrom's macroglobulinaemia (wm), we investigated dna samples from 20 bone marrow biopsies with wm for the detection of kshv by pcr (ks330/orf26). we performed two rounds of amplification and found that only 1/20 of the dna samples obtained from biopsies had a detectable kshv sequence. the positive patient was ... | 1998 | 9722309 |
| antibodies to kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in patients with multiple myeloma. | kaposi's sarcoma-associated herpesvirus (kshv) serologic assays were used to detect specific antibodies to kshv lytic and latent antigens in 27 patients with multiple myeloma, 27 control patients with other cancers, and 50 random blood donors. antibodies to kshv recombinant minor capsid antigen orf65 were found in 81% of patients with multiple myeloma, 22% of control patients with other cancers, and 6% of the blood donors. antibodies to kshv latent nuclear antigens were found in 52% of patients ... | 1998 | 9728556 |
| establishment and characterization of ebv-positive and ebv-negative primary effusion lymphoma cell lines harbouring human herpesvirus type-8. | in this study we report on the establishment and characterization of two novel lymphoma cell lines (cro-ap/3 and cro-ap/5) which carry infection by human herpesvirus type-8 (hhv-8) and have derived from aids-related primary effusion lymphoma (pel). these two cell lines are representative of different virologic subtypes of pel, i.e. hhv-8+/ebv- pel in the case of cro-ap/3 and hhv-8+/ebv+ pel in the case of cro-ap/5. consistent with the diagnosis of pel, both cro-ap/3 and cro-ap/5 expressed indete ... | 1998 | 9734661 |
| human herpesvirus-8 orf k8.1 gene encodes immunogenic glycoproteins generated by spliced transcripts. | a cdna library from phorbol ester-induced human herpesvirus-8 (hhv-8) carrying bcbl-1 cells was screened with an hiv+ks+ serum, and several cdna clones encoding hhv-8 proteins were identified. sequence analysis of two full-length cdna clones show open reading frames (orfs) encoded by spliced messages originating from the hhv-8 k8.1 gene. one cdna encodes an orf of 228 amino acids, designated k8. 1.a, with a cleavable signal sequence, a transmembrane domain, and four n-glycosylation sites. the sp ... | 1998 | 9740785 |
| spectrum of aids-associated malignant disorders. | 1998 | 9743013 | |
| transfusion virology: progress and challenges. | discoveries of new human viruses and new technologies for their detection have made, and will continue to make, major contributions to the safety of blood transfusion. this article discusses the practical issues involved in the implementation of additional serological screening tests for viruses such as human t-lymphotropic virus, and reviews current information on the prevalence and pathogenicity of more recently discovered viruses, such as hepatitis g virus (hgv) or gb virus-c (gbv-c) and huma ... | 1998 | 9745887 |
| dendritic cells derived from bone marrow and cd34+ selected blood progenitor cells of myeloma patients, cultured in serum-free media, do not contain the kaposi sarcoma herpesvirus genome. | the aim of our study was to test if dendritic cells contain the kshv genome. cd34+ peripheral blood progenitor cells (pbpc) and bone marrow mononuclear cells were cultured in x-vivo 15 medium supplemented with gm-csf and tnf-alpha in gas-permeable containers. dendritic cells were identified morphologically and immunophenotypically. the kshv genome was not identified in any of the cases using a nested primer pcr approach. serological analysis corroborated the molecular findings: no antibodies for ... | 1998 | 9753067 |
| squamous cell carcinomas after allogeneic bone marrow transplantation for aplastic anemia: further evidence of a multistep process. | secondary solid tumors are rare events occurring in patients who underwent allogeneic marrow transplantation for aplastic anemia and fanconi's anemia. human herpes virus 8 (hhv8), epstein-barr virus (ebv), and human papillomaviruses (hpv) sequences have been found in squamous cell carcinoma (scc) occurring in organ transplant recipients. the tumor suppressor gene p53 has been strongly linked to the occurrence of scc in the nonimmunocompromised population. | 1998 | 9753353 |
| purification of kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) and analyses of the structural proteins. | the kaposis's sarcoma-associated herpesvirus (kshv) infected bcbl-1 cell line, adapted to and grown in medium containing 10% horse serum, was induced to lytic replication with 12-o-tetradecanoylphorbol-13-acetate (tpa) for virus production. supernatants from induced cells were filtered through a 0.45-microm filter and virions were concentrated by polyethylene glycol extraction and high speed centrifugation. the virus was purified by a glycerol gradient zonal centrifugation step followed by isopy ... | 1998 | 9766893 |
| prevalence of human herpesvirus 8 antibodies in human immunodeficiency virus type 1-infected homosexual men in slovakia. | 1998 | 9770082 | |
| comparison of the prevalence of antibodies to human herpesvirus 8 (kaposi's sarcoma-associated herpesvirus) in brazil and colorado. | the prevalence of human herpesvirus 8 (hhv-8; kaposi's sarcoma [ks] herpesvirus) infection was determined by ifa in 297 persons living in brazil and colorado. the prevalence of antibody to hhv-8 in human immunodeficiency virus (hiv) type 1-seropositive gay men with and without ks was similar in brazil and colorado. in brazil, the prevalence of hhv-8 antibody was significantly greater in hiv-1-seronegative gay men than in hiv-1-seronegative male intravenous drug users. hhv-8-seropositive brazilia ... | 1998 | 9780272 |
| kaposi's sarcoma-associated herpesvirus in kikuchi's disease. | kikuchi's disease is a fairly common self-limited disorder among orientals that usually involves the cervical lymph nodes of young individuals and occurs predominantly in females. frequently, the disease is associated with fever or flu-like symptoms, an elevated erythrocyte sedimentation rate (esr), neutropenia, and lymphocytosis with atypical lymphocytes in the peripheral blood, suggesting a viral origin. however, no infectious agent has been identified. the presence of kaposi sarcoma-associate ... | 1998 | 9781647 |
| human herpesvirus-8 and relatives of patients with plasmocytic diseases. | 1998 | 9787198 | |
| chemokines activate kaposi's sarcoma-associated herpesvirus g protein-coupled receptor in mammalian cells in culture. | kaposi's sarcoma-associated herpesvirus (kshv)/human herpesvirus 8, a virus that appears to be involved in the pathogenesis of kaposi's sarcoma and primary effusion lymphomas, encodes a g protein-coupled receptor (kshv-gpcr) that exhibits constitutive signaling. in this report, we show that two chemokines, interleukin 8 (il-8) and growth-related protein-alpha, activate kshv-gpcr over constitutive levels. moreover, as with human receptors, the integrity of the elr motif of these chemokines is req ... | 1998 | 9788958 |
| [painless, red-violet skin lesions during immunosuppression]. | a patient with painless, bluish-red skin lesions under immunosuppressive treatment for kidney transplantation is presented. the clinical and histological diagnosis was kaposi's sarcoma. this is a rare but serious complication in the immunocompromised patient. human herpes virus 8 (hhv 8) was recently found in the lesions from patients with kaposi's sarcoma. this supports the important role of immunosuppression in the development of this tumor. therapy consists of reduction or stopping of the imm ... | 1998 | 9789478 |
| trauma-induced kaposi's sarcoma of the hallux. an unusual case. | kaposi's sarcoma is the most common malignant lesion in patients who test seropositive for the human immunodeficiency virus. although many cases of this tumor have been described in the literature, only a few cases have been related to koebner's phenomenon following trauma. biopsy of lesions remains the standard method of diagnosis, but the numerous treatment options available today require treatment to be determined on a case-by-case basis. the authors present an unusual case of trauma-induced, ... | 1998 | 9791955 |
| increasing kaposi's sarcoma-associated herpesvirus seroprevalence with age in a highly kaposi's sarcoma endemic region, zambia in 1985. | kaposi's sarcoma (ks)-associated herpesvirus (kshv) is a newly discovered virus found in all forms of ks. in the united states, kshv infection appears to be most common amongst individuals at high-risk for ks. preliminary data from africa suggest that kshv infection may be much more common in the general population. | 1998 | 9792393 |
| the pathogenesis of kaposi's sarcoma. | 1998 | 9795583 | |
| aids-related malignancies. | 1998 | 9800109 | |
| immunoglobulin vh gene mutational analysis suggests that primary effusion lymphomas derive from different stages of b cell maturation. | primary effusion lymphoma (pel) is a recently described distinct subtype of non-hodgkin's lymphoma associated with infection by the kaposi's sarcoma-associated herpesvirus, also called human herpesvirus-8. most cases of pel are also associated with the epstein-barr virus (ebv). in order to better characterize the cellular origin of pel, we investigated the immunoglobulin (ig) heavy chain variable region (vh,) genes expressed by tumor cells of the bc-1 and bc-3 cell lines derived from pels and fi ... | 1998 | 9811353 |
| distinct biology of kaposi's sarcoma-associated herpesvirus from primary lesions and body cavity lymphomas. | the dna sequence for kaposi's sarcoma-associated herpesvirus was originally detected in kaposi's sarcoma biopsy specimens. since its discovery, it has been possible to detect virus in cell lines established from aids-associated body cavity-based b-cell lymphoma and to propagate virus from primary kaposi's sarcoma lesions in a human renal embryonic cell line, 293. in this study, we analyzed the infectivity of kaposi's sarcoma-associated herpesvirus produced from these two sources. viral isolates ... | 1998 | 9811747 |
| new advances in multiple myeloma. | recent studies have led to new insights into the pathogenesis of multiple myeloma, including appreciation of the potential role of human herpesvirus-8 infection and further characterization of some of the cytogenetic abnormalities present in this disease. new strategies to optimize the use of allogeneic and autologous stem cell transplantation include the development of various immunotherapeutic techniques to enhance the antitumor effect, and, in the case of allogeneic transplantation, to reduce ... | 1998 | 9814656 |
| detection of human herpesvirus 8 dna sequences in tissues and bodily fluids. | human herpesvirus 8 (hhv-8) has been proposed as a sexually transmitted etiologic agent of kaposi's sarcoma (ks). in this study, by use of a sensitive polymerase chain reaction assay, hhv-8 dna was detected in the skin lesions (92%), normal skin (23%), peripheral blood mononuclear cells (pbmc) (46%), plasma (7%), saliva (37%), and semen (12%) but not stool samples from ks patients. the average number of hhv-8 copies per microgram of positive target dna was 64, 000, 9000, 40, 33,000, and 300 for ... | 1998 | 9815212 |
| seroprevalence of human herpesvirus 8 among zambian women of childbearing age without kaposi's sarcoma (ks) and mother-child pairs with ks. | the seroprevalence of human herpesvirus 8 (hhv-8) among a group of zambian women of reproductive age and among mother-child pairs in which either one of them has kaposi's sarcoma (ks) was determined. a cross-sectional group of 378 pregnant women was randomly recruited into the study, and 183 (48.4%) had hhv-8 antibodies. among the human immunodeficiency virus (hiv)-1-infected women, 51.1% were hhv-8-seropositive, whereas of hiv-1-negative women, 47.3% were hhv-8-seropositive. in addition, 21 wom ... | 1998 | 9815235 |
| further confirmation of the association of human herpesvirus 8 with kaposi's sarcoma. | recently, a new herpesvirus-like dna sequence named kaposi's sarcoma-associated herpesvirus (kshv) or human herpesvirus 8 (hhv8) has been isolated from almost all cases of kaposi's sarcoma (ks). it has not been found in most benign and malignant cutaneous hemangioproliferative disorders other than ks. to further verify the specificity of the association of this new viral dna with ks, we examined in total 42 cases of vascular neoplasms of endothelial derivation using nested polymerase chain react ... | 1998 | 9826166 |
| diva, a bcl-2 homologue that binds directly to apaf-1 and induces bh3-independent cell death. | we have identified and characterized diva, which is a novel regulator of apoptosis. sequence analysis revealed that diva is a member of the bcl-2 family of proteins containing bcl-2 homology domain 1, 2, 3, and 4 (bh1, bh2, bh3, and bh4) regions and a carboxyl-terminal hydrophobic domain. the expression of diva mrna was detected in multiple embryonic tissues but was restricted to the ovary and testis in adult mice. the expression of diva promoted the death of 293t, ramsey, and t47d cells as well ... | 1998 | 9829980 |
| human herpesvirus-8 glycoprotein b interacts with epstein-barr virus (ebv) glycoprotein 110 but fails to complement the infectivity of ebv mutants. | to characterize human herpesvirus 8 (hhv-8) gb, the open reading frame was pcr amplified from the hhv-8-infected cell line bcbl-1 and cloned into an expression vector. to facilitate detection of expressed hhv-8 gb, the cytoplasmic tail of the glycoprotein was tagged with the influenza hemagglutinin (ha) epitope. expression of tagged hhv-8 gb (gb-ha), as well as the untagged form, was readily detected in cho-k1 cells and several lymphoblastoid cell lines (lcls). hhv-8 gb-ha was sensitive to endog ... | 1998 | 9837804 |
| herpes virus type 8-negative primary effusion lymphoma associated with pax-5 gene rearrangement and hepatitis c virus: a case report and review of the literature. | at present, there is no case report of hhv8- primary effusion lymphoma (pel) with t(9;14)(p13;q32) involving both pax-5 and immunoglobulin heavy chain gene rearrangement, which is a rare translocation in b-cell non-hodgkin's lymphoma, in an hiv- patient. we examined an hiv-seronegative 63-year-old japanese man with hepatitis c virus-associated liver cirrhosis and hepatocellular carcinoma manifesting peritoneal lymphomatous effusion without tumor mass at any body site. the lymphoma cells were exa ... | 1998 | 9850179 |
| hhv-8 is not associated with follicular dendritic cell tumours. | follicular dendritic cell tumours are rare malignancies derived from the follicular dendritic cells of lymphoid follicles. these tumours have been associated with epstein-barr virus infections and with the hyaline vascular subtype of castleman's disease. because many examples of castleman's disease have been associated with kaposi's sarcoma associated herpes virus (hhv-8), this study uses polymerase chain reaction technology to examine five cases of follicular dendritic cell tumours for hhv-8. o ... | 1998 | 9850342 |
| the association of skin diseases with human herpesvirus 8 infection in hiv carriers. | the seroprevalence to kaposi's sarcoma-associated herpesvirus (kshv) or human herpesvirus type 8 (hhv-8) was surveyed in human immunodeficiency virus type 1 (hiv-1) carriers with or without skin diseases, and also in hiv-1 negative individuals in thailand. using an immunofluorescence assay, the seropositive rates to lytic antigens of hhv-8 in hiv-1 carriers with or without skin diseases were 25% and 7.4%, respectively, but none of hiv-1 negative individuals had antibody. the seroprevalence to hh ... | 1998 | 9856078 |
| cardiac tamponade in a patient with aids: a review of pericardial disease in patients with hiv infection. | pericarditis in patients with human immunodeficiency virus (hiv) infection may be asymptomatic or symptomatic, but is sometimes overlooked because of signs and symptoms of other organ system diseases. a case report of cardiac tamponade in a patient with acquired immunodeficiency syndrome (aids) is presented. to determine the incidence and causes of pericardial disease in patients with hiv infection, a review of the literature was conducted. fifteen autopsy and echocardiographic series involving ... | 1998 | 9458682 |
| randomized comparative trial of pegylated liposomal doxorubicin versus bleomycin and vincristine in the treatment of aids-related kaposi's sarcoma. international pegylated liposomal doxorubicin study group. | cytotoxic chemotherapy is frequently required for the more severe manifestations of human immunodeficiency virus (hiv)-related kaposi's sarcoma. combinations of bleomycin and vincristine (bv) or bv with the addition of doxorubicin (abv) are the most commonly used regimens against which new treatments may be compared. we report a multicenter phase iii study that compared pegylated liposomal doxorubicin (pld) to the bv combination. | 1998 | 9469358 |
| human herpesvirus 8 variants. | 1998 | 9500366 | |
| serologic association of human herpesvirus eight with posttransplant kaposi's sarcoma in saudi arabia. | this study investigates the association between human herpesvirus eight (hhv8) and kaposi's sarcoma (ks), the most common cancer occurring in renal transplant recipients in saudi arabia. | 1998 | 9500639 |
| mechanisms of growth control of kaposi's sarcoma-associated herpes virus-associated primary effusion lymphoma cells. | primary effusion lymphoma (pel) is a distinct clinicopathologic entity associated with kaposi's sarcoma-associated herpes virus (kshv). several cytokines, including interleukin-6 (il-6), basic fibroblast growth factor (bfgf), and platelet-derived growth factor (pdgf) may be important for survival of ks cells. however, little is known about the interaction of cytokines with kshv-infected lymphocytes from pel. therefore, we investigated what cytokines were produced by kshv-infected pel cell lines ... | 1998 | 9516148 |
| reactivities of human sera with human herpesvirus-8-infected bcbl-1 cells and identification of hhv-8-specific proteins and glycoproteins and the encoding cdnas. | the reactivates of human sera with uninduced and phorbol ester (tpa)-induced human herpesvirus-8 (hhv-8)-infected bcbl-1 cells were examined by immunofluorescence assay (ifa) and by radioimmunoprecipitation reactions (rip). the seroprevalence of hhv-8 infections is low in the united states general population and only low levels of hhv-8 antibodies were detected in the seropositive sera. in contrast, high levels of antibodies against hhv-8 lytic and latent antigens were detected by ifa in the ser ... | 1998 | 9527930 |
| emerging viruses. | an emerging virus is a term applied to a newly discovered virus, one that is increasing in incidence or with the potential to increase in incidence. many viruses fit into this definition. hiv is the clearest example of a previously unknown virus that has now produced one of the largest pandemics in history. recent advances have occurred in the identification and understanding of new hantaviruses in the americas, causing an acute respiratory disease. the possible causal role of human herpesvirus ... | 1998 | 9529635 |
| human herpesvirus 8 in premalignant and cancerous skin lesions in a japanese patient with adult t-cell leukaemia. | 1998 | 9531356 | |
| molecular and pathologic characterization of an aids-related body cavity-based lymphoma, including ultrastructural demonstration of human herpesvirus-8: a case report. | body cavity-based lymphoma, also known as primary effusion lymphoma, is a newly recognized acquired immunodeficiency syndrome (aids)-related lymphoma that has been linked to the kaposi's sarcoma-associated herpesvirus (kshv/hhv-8). to date, direct visualization of the virus in a clinical sample has not been demonstrated. we have performed an extensive clinical, histologic, immunophenotypic, ultrastructural, and molecular genetic correlative study on multiple tissue samples obtained premortem and ... | 1998 | 9537479 |
| human herpesvirus 8 in kaposi's sarcoma and kaposi's sarcoma-mimicking vascular tumors. | kaposi's sarcoma (ks) had been a rare and unusual vascular tumor until a recent epidemic of a disseminated and fulminant form of ks in aids patients. infectious agents have been suspected of causing ks, and recently partial genomic dna sequences of human herpesvirus 8 (hhv8) have been identified in aids-associated ks lesions. since then, genomic dna sequences of hhv8 have been isolated in other forms of ks. although the partial genomic dna sequence of hhv8 was reported to be, if rare, identified ... | 1998 | 9539320 |
| seroprevalence of human herpesvirus-8 in healthy subjects and patients with aids-associated and classical kaposi's sarcoma in france. | 1998 | 9543459 | |
| aids-related primary lymphoma of the pleural cavity. a case report. | pleural effusions are common in patients with the acquired immunodeficiency syndrome (aids). their most frequent causes are kaposi's sarcoma and mycobacterial infections. we report cytologic, immunophenotypic and molecular features of a primary pleural non-hodgkin's lymphoma (nhl) that represent an uncommon cause of isolated pleural effusion in patients with aids. | 1998 | 9568138 |
| limited transmission of kaposi's sarcoma-associated herpesvirus in cultured cells. | kaposi's sarcoma-associated herpesvirus (kshv) (also called human herpesvirus 8) is a novel gammaherpesvirus strongly implicated in the pathogenesis of kaposi's sarcoma. although virions can be produced in high yield from latently infected b-cell lines treated with phorbol esters, little is known about the infectivity of such virus, and efficient serial propagation of kshv has been problematic. here we report on the infectivity of kshv produced from phorbol-induced bcbl-1 cells, employing an ass ... | 1998 | 9573290 |
| an unusual localisation of kaposi's sarcoma: the external auditory canal. | the epidemic form of kaposi's sarcoma is associated with human immunodeficiency virus infection. cutaneous and mucosal manifestations are frequently reported in the ent sphere, mostly involving the oral cavity. the external and middle ear are only rarely concerned with only one case of a mastoid lesion without extension to the external auditory canal (eac) being reported to this day. the present article describes the first case of involvement of the eac with extension to adjacent structures. thi ... | 1998 | 9581194 |
| kaposi's sarcoma in liver transplant recipients on fk506. | 1998 | 9583882 | |
| cancer in human immunodeficiency virus-infected children: a case series from the children's cancer group and the national cancer institute. | to describe the spectrum of malignancies in human immunodeficiency virus (hiv)-infected children and the clinical outcome of patients with these tumors. | 1998 | 9586885 |
| absence of human herpesvirus 8 dna sequences in vascular tumors of the liver. | kaposi's sarcoma-associated herpes virus (kshv), also designated human herpesvirus 8 (hhv8), has been detected consistently in kaposi's sarcoma, body cavity lymphoma and multicentric castleman's disease, both in human immunodeficiency virus (hiv)-positive and -negative patients. identification of kshv/hhv8 dna sequences in various benign and malignant vascular tumors in hiv-negative patients was reported in one study, but was not confirmed in several other studies. the vascular lesions, other th ... | 1998 | 9588771 |
| seroprevalence of kaposi's sarcoma-associated herpes virus antibody in young adult hodgkin's disease. | 1998 | 9439351 | |
| transcription mapping of the kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) genome in a body cavity-based lymphoma cell line (bc-1). | kaposi's sarcoma-associated herpesvirus (kshv) gene transcription in the bc-1 cell line (kshv and epstein-barr virus coinfected) was examined by using northern analysis with dna probes extending across the viral genome except for a 3-kb unclonable rightmost region. three broad classes of viral gene transcription have been identified. class i genes, such as those encoding the v-cyclin, latency-associated nuclear antigen, and v-flip, are constitutively transcribed under standard growth conditions, ... | 1998 | 9444993 |
| gamma-interferon produced by cd8+ t cells infiltrating kaposi's sarcoma induces spindle cells with angiogenic phenotype and synergy with human immunodeficiency virus-1 tat protein: an immune response to human herpesvirus-8 infection? | kaposi's sarcoma (ks) is an angioproliferative disease associated with infection by the human herpesvirus-8 (hhv-8). hhv-8 possesses genes including homologs of interleukin-8 (il-8) receptor, bcl-2, and cyclin d, which can potentially transform the host cell. however, the expression of these genes in ks tissues is very low or undetectable and hhv-8 does not seem to transform human cells in vitro. in addition, ks may not be a true cancer at least in the early stage. this indicated that besides it ... | 1998 | 9446657 |
| future trends in kaposi's sarcoma and lymphoma. | 1998 | 9874115 | |
| [human herpesvirus-8 in hungarian blood donors and in patients with kaposi sarcoma]. | the pathogenic role of kaposi's sarcoma associated herpesvirus or human herpesvirus-8 in the development of kaposi's sarcoma is widely accepted today. here the authors report an indirect immunofluorescence assay based seroepidemiologic study. their results indicate that 1.56% (17/1089) of the hungarian adult population and 100% (12/12) of kaposi's sarcoma patients have serum antibodies to hhv-8 latent nuclear antigens. | 1998 | 9876459 |
| accessibility of selenomethionine proteins by total chemical synthesis: structural studies of human herpesvirus-8 mip-ii. | the determination of high resolution three-dimensional structures by x-ray crystallography or nuclear magnetic resonance (nmr) is a time-consuming process. here we describe an approach to circumvent the cloning and expression of a recombinant protein as well as screening for heavy atom derivatives. the selenomethionine-modified chemokine macrophage inflammatory protein-ii (mip-ii) from human herpesvirus-8 has been produced by total chemical synthesis, crystallized, and characterized by nmr. the ... | 1998 | 9877169 |
| human herpesvirus 8 is not associated with kawasaki disease. | 1998 | 9877378 | |
| [hhv-8 related diseases]. | kaposi's disease: hhv-8 sequences have been found in all the epidemiological forms of kaposi's disease. there is a direct relationship between hhv-8 infection and pbmc and later development of kaposi's disease. the hhv-8 sequences can be found in spindle cells or endothelial cells in kaposi lesions. other diseases: hhv-8 is also associated with certain lymphomas including body-cavity-based lymphomas and castleman's disease. it has also been put forward that there is a relationship between hhv-8 ... | 1998 | 9879330 |
| hypothesis. hhv-8 in multiple myeloma: is this the first paracrine model of human tumorigenesis and do koch's postulates apply? | 1998 | 9893745 | |
| epidemiology, etiology and pathogenesis, clinical presentations and therapeutic approaches in kaposi's sarcoma: 15-year lessons from aids. | kaposi's sarcoma (ks) is a leading cause of morbidity among 25-30% of aids patients and is by far the most common aids-associated malignancy. since the beginning of the 1990s the incidence of ks continuously declined, but it was the introduction of protease inhibitors that markedly reinforced this phenomenon. in our experience, the annual incidence was 59/1,000 patient-years in 1984 vs 21.2/1,000 patient-years in 1990, 12.5/1,000 patient-years in 1996, with a drop to 3.2/1,000 patient-years in 1 ... | 1998 | 9921413 |
| localization of human herpesvirus type 8 (hhv-8) in the kaposi's sarcoma tissues and the semen specimens of hiv-1 infected and uninfected individuals by utilizing in situ polymerase chain reaction. | kaposi's sarcoma (ks) is a form of skin cancer, most commonly found in individuals suffering from acquired immunodeficiency syndrome, or aids. however, before the worldwide infection of human immunodeficiency virus (hiv), the rare occurrence of ks was confined to two distinct groups of individuals. in the western world, the classical form of ks was often found in older men (60-70 years of age) from the mediterranean area. another form called endemic ks, was found in equatorial africa. currently, ... | 1998 | 10213307 |
| kaposi's sarcoma-associated herpesvirus (kshv) chemokine vmip-ii and human sdf-1alpha inhibit signaling by kshv g protein-coupled receptor. | kaposi's sarcoma-associated herpesvirus (kshv) encodes two proteins that are similar to human cc chemokines and a g protein-coupled receptor (kshv-gpcr) that is constitutively active. kshv-gpcr binds a number of human cxc and cc chemokines. we showed that interferon gamma-inducible protein-10 (ip-10), a human cxc chemokine, inhibits kshv-gpcr signaling (geras-raaka et al., j. exp. med. 188, 405-408, 1998). here we show that viral monocyte inflammatory protein-ii (vmip-ii), one of the kshv-encode ... | 1998 | 9918794 |
| viruses and human cancer. | several kinds of viruses cause cancer in humans, accounting for 10-20% of cancer worldwide. human cancer viruses include human papillomavirus, hepatitis b virus, epstein-barr virus, human t cell lymphotropic virus, and kaposi's sarcoma-associated herpesvirus. cancer viruses alter the machinery of the infected cell to promote their own survival and growth. in the process, they interfere with normal cellular control mechanisms, leading to abnormal growth, genetic alterations and malignancy. studie ... | 1998 | 10093516 |
| seroprevalence of human immunodeficiency virus type 1 infection in childhood malignancy in zimbabwe. | to determine the association between malignancy and the human immunodeficiency virus type 1 (hiv-1) infection in children. | 1998 | 10101432 |
| distinct serum cytokines in aids-related skin diseases. | to determine whether common skin diseases associated with human immunodeficiency virus (hiv) were distinguishable based on the pattern of serum cytokine expression, we studied patients with psoriasis, pruritus, and kaposi's sarcoma (ks) for levels of tumor necrosis factor (tnf)-alpha, interferon-gamma (ifn-y), interleukin (il)-10, and il-4. thirty-two hiv-positive (hiv+) patients including 8 with ks, 11 with psoriasis, and 13 with pruritus along with 16 hiv-negative subjects with psoriasis were ... | 1998 | 10189188 |
| aids-related kaposi's sarcoma patients with visceral manifestations. response to human chorionic gonadotropin preparations. | in vitro cell culture studies and a murine model for human kaposi's sarcoma (ks) have shown that human chorionic gonadotropin (hcg)-associated factor (haf) isolated from commercial hcg preparations has antiproliferative and cell killing effects on neoplastic ks cells, without toxic effects on normal endothelial cells and lymphocytes. these findings prompted preliminary study of hcg preparations for patients with early-stage ks with skin lesions only and no known visceral involvement. complete or ... | 1998 | 10195236 |
| kaposi's sarcoma in the gambia, west africa is less frequent in human immunodeficiency virus type 2 than in human immunodeficiency virus type 1 infection despite a high prevalence of human herpesvirus 8. | to investigate the distribution of kaposi's sarcoma (ks) cases in patients with human immunodeficiency virus types 1 and 2 (hiv-1 and hiv-2) infection in the gambia; to document the prevalence of human herpesvirus 8 (hhv-8) infection in various population groups in the gambia. | 1998 | 10195242 |
| kaposi sarcoma-associated herpesvirus/human herpesvirus 8, cytokines, growth factors and hiv in pathogenesis of kaposi's sarcoma. | epidemiological studies have strengthened the case for kaposi sarcoma-associated herpesvirus/human herpesvirus 8 being the long-sought kaposi sarcoma agent, but have also pointed to a role for other co-factors. like other tumour viruses, kaposi sarcoma-associated herpesvirus/human herpesvirus 8 establishes a latent (persistent) infection in kaposi sarcoma-spindle (tumorous) cells, but can also undergo lytic replication in these and other cell types. several latent and lytic viral genes may play ... | 1998 | 17033372 |
| dermatological infections in the immunocompromised host. | the data from the most recent studies concerning infection with human herpes virus 8 strongly support a pathogenic role for this virus in the tumoral hyperplasia which is a feature of kaposi's sarcoma. the results from the first studies of the sensitivity of human herpes virus 8 to antiviral drugs were also published last year. this review also concerns bacterial and mycobacterial infections showing unusual presentation, important trials in the prevention of infection with varicella zoster virus ... | 1998 | 17033375 |
| cellular tropism and viral interleukin-6 expression distinguish human herpesvirus 8 involvement in kaposi's sarcoma, primary effusion lymphoma, and multicentric castleman's disease. | human herpesvirus 8 (hhv-8) infection has been implicated in the etiology of kaposi's sarcoma (ks), primary effusion lymphoma (pel), and multicentric castleman's disease (mcd), three diseases that frequently develop in immunocompromised, human immunodeficiency virus-positive individuals. one hypothesis that would account for different pathological manifestations of infection by the same virus is that viral genes are differentially expressed in heterogeneous cell types. to test this hypothesis, w ... | 1999 | 10196314 |
| human herpesvirus 8 (hhv-8) in familial kaposi's sarcoma. | human herpesvirus 8 (hhv-8) has been detected in various epidemiological forms of kaposi's sarcoma (ks). since familial ks cases are exceedingly rare and the occurrence of familial ks in siblings has thought to depend rather on genetic factors than on a viral factor, familial ks has not been investigated for the presence of hhv-8. to investigate whether hhv-8 is present also in this rare form of ks, we examined tumor biopsies of 2 siblings with familial ks for the presence of hhv-8 specific dna ... | 1999 | 10206723 |
| human herpesvirus 8 and renal transplantation. | 1999 | 10189288 | |
| comparison of human sera reactivities in immunoblots with recombinant human herpesvirus (hhv)-8 proteins associated with the latent (orf73) and lytic (orfs 65, k8.1a, and k8.1b) replicative cycles and in immunofluorescence assays with hhv-8-infected bcbl-1 cells. | the development of reliable, sensitive, and specific serological methods for the detection of human herpesvirus-8 (hhv-8) antibodies is critical for a thorough understanding of hhv-8 prevalence and pathogenesis. to evaluate the potential usefulness of hhv-8 proteins in measuring the responses against both latent and lytic antigens, we selected 1 latent [open reading frame (orf) 73] antigen and 3 hhv-8 lytic antigens (orfs 65, k8.1a, and k8.1b) previously identified as immunogenic [virology (1998 ... | 1999 | 10191203 |
| hhv-8 and multiple myeloma. | recently, a new member of the gamma-herpesvirus family, human herpesvirus 8 (hhv-8), was identified in a case of kaposi's sarcoma. this virus has also been found in the nonmalignant dendritic cells of the bone marrow from myeloma patients. in addition, hhv-8 is also detectable in the peripheral blood of most patients although its absence suggests earlier stage disease. by contrast, this virus is undetectable in the blood of family members and sexual partners of myeloma patients. sequencing of hh ... | 1999 | 10192878 |
| hydrocortisone activation of human herpesvirus 8 viral dna replication and gene expression in vitro. | patients undergoing chronic steroid therapy for organ transplantation are at increased risk for development of human herpes virus 8(hhv-8)-associated kaposi's sarcoma (ks). it has also been reported that following steroid withdrawal, ks lesions often undergo partial or complete regression. | 1999 | 10096517 |
| detection and sequence diversity of kaposi's sarcoma-associated herpesvirus (kshv)/human herpesvirus 8 (hhv-8) dna. | detection of kaposi's sarcoma (ks)-associated herpesvirus (kshv)/human herpesvirus (hhv-8) has been reported frequently in patients with ks associated with acquired immunodeficiency syndrome (aids). we examined the presence of the kshv sequence in 8 hiv-positive patients comprising 5 with ks, 2 with syphilis, 1 with prurigo, and 2 hiv-negative patients with angiosarcoma. using the polymerase chain reaction, we observed amplification of a dna fragment of the expected size in 4 patients with ks. s ... | 1999 | 9920979 |
| agonists and inverse agonists for the herpesvirus 8-encoded constitutively active seven-transmembrane oncogene product, orf-74. | a number of cxc chemokines competed with similar, nanomolar affinity against 125i-interleukin-8 (il-8) binding to orf-74, a constitutively active seven-transmembrane receptor encoded by human herpesvirus 8. however, in competition against 125i-labeled growth-related oncogene (gro)-alpha, the orf-74 receptor was highly selective for gro peptides, with il-8 being 10,000-fold less potent. the constitutive stimulating activity of orf-74 on phosphatidylinositol turnover was not influenced by, for exa ... | 1999 | 9873037 |
| the role of human herpesvirus 8 in the pathogenesis of kaposi's sarcoma. | human herpesvirus 8 is a novel gamma-herpesvirus that has been linked with all clinical types of ks through both dna and serologic studies. by electron microscopic, in situ hybridization, and in situ pcr studies, virus is found in tumor spindle cells, in normal-appearing endothelial cells within lesions, and in tumor-infiltrating leukocytes. the fact that most tumor cells are latently, as opposed to lytically, infected with hhv8 makes the possibility of treating ks patients with antiherpesviral ... | 1999 | 10643499 |
| cyclin d1 expression and hhv8 in kaposi sarcoma. | human herpesvirus 8 (hhv8) appears to be the agent responsible for kaposi sarcoma. the mechanism remains undetermined but may involve cell cycle regulating genes including d type cyclins which are pivotal in cell cycle progression. recent hhv8 genetic analysis has revealed the presence of a v-cyclin which is homologous to d type cyclins. | 1999 | 10645225 |
| p53 inhibition by the lana protein of kshv protects against cell death. | kaposi's sarcoma-associated herpesvirus (kshv), or human herpesvirus 8, has been implicated in the development of kaposi's sarcoma (ks) and several b-cell lymphoproliferative diseases. most cells in lesions derived from these malignancies are latently infected, and different viral gene products have been identified in association with lytic or latent infection by kshv. the latency-associated nuclear antigen (lana), encoded by open reading frame 73 of the kshv genome, is a highly immunogenic prot ... | 1999 | 10622254 |
| the role of human herpesvirus-8 in the pathogenesis of multiple myeloma. | human herpesvirus-8 has been strongly implicated in the pathogenesis of ks, bcbl, and multicentric castleman's disease. evidence for its role in the pathogenesis of multiple myeloma is accumulating. human herpesvirus-8 is detectable in the nonmalignant bone marrow dendritic cells from most myeloma patients. in addition, hhv-8 is also detected in the peripheral blood of most myeloma patients. in contrast, this virus is rarely detected in close contacts of myeloma patients, healthy individuals, or ... | 1999 | 10626142 |
| kaposi's sarcoma of the pancreas mimicking pancreatic cancer in an hiv-infected patient. clinical diagnosis by detection of hhv 8 in bile and complete remission following antiviral and cytostatic therapy with paclitaxel. | diagnosis of pancreatic cancer is usually made by endoscopic retrograde cholangiopancreatography (ercp) and corresponding findings in computed tomography (ct) or magnetic resonance imaging. kaposi's sarcoma, a frequent tumor in individuals with a late-stage hiv infection, can be located in the gastrointestinal tract and cause identical symptoms to carcinoma of the same site. a close correlation of this tumor to human herpes virus 8 (hhv 8) has been known for several years and there are reports o ... | 1999 | 10732297 |
| clinical management of selected oral fungal and viral infections during hiv-disease. | the purpose of this review is to describe current possibilities of management of selected fungal and viral oral opportunistic infections including oral candidiasis, herpes simplex type 1 and 2-related lesions (hsv1,2), oral hairy leukoplakia (ohl) and oral lesions associated with human papilloma viruses (hpv). less common diseases such as cytomegalovirus infection or human herpes virus type 8 associated with kaposi's sarcoma and others are not considered. in a number of instances lifelong therap ... | 1999 | 10858761 |
| absence of human herpesvirus-8 dna in angiosarcoma. | 1999 | 10215793 | |
| pleural fluid findings in patients with the acquired immunodeficiency syndrome: correlation with concomitant pulmonary disease. | we sought to define the spectrum of conditions associated with pleural effusion (pe) in patients with the acquired immunodeficiency syndrome (aids) who submitted to diagnostic thoracentesis. | 1999 | 10219358 |
| identification and characterization of human herpesvirus 8 open reading frame k9 viral interferon regulatory factor by a monoclonal antibody. | to identify and characterize an open reading frame (orf) in association with its mrna and a coding protein recognized by anti-human herpesvirus 8 (hhv-8) monoclonal antibody b291. | 1999 | 10225208 |
| detection of human herpesvirus 8 in cervicovaginal secretions and seroprevalence in human immunodeficiency virus type 1-seropositive and -seronegative women. | epidemiologic studies suggest that human herpesvirus 8 (hhv-8) may be sexually transmitted. to study the potential for hhv-8 transmission through cervicovaginal (cv) secretions, the presence of hhv-8 dna was investigated by nested polymerase chain reaction in the cellular fraction of cv secretions from 36 human immunodeficiency virus type 1 (hiv-1)-seropositive and 29 hiv-1-seronegative women. the same patients were tested for antibodies to two defined hhv-8 antigens (latency-associated nuclear ... | 1999 | 10228077 |
| human herpesvirus-8 (hhv-8) gene expression in kaposi's sarcoma (ks) primary lesions: an in situ hybridization study. | 1999 | 10232382 | |
| relationship of hhv8 replication and kaposi's sarcoma after solid organ transplantation. | hhv8 dna sequences have recently been isolated from all types of kaposi's sarcomas, and its association in the etiopathogenesis of this tumor has been established. however, little is known about the regulation of hhv8 replication in immunocompromised patients seropositive for this virus, and its impact on the development of kaposi's sarcoma (ks). through the study of a heart transplant patient who developed ks and in whom peripheral blood lymphocytes (pbls) had been prospectively collected befor ... | 1999 | 10232577 |
| kaposi's sarcoma-associated herpesvirus and multiple myeloma: lack of criteria for causality. | 1999 | 10233868 | |
| paclitaxel in the treatment of human immunodeficiency virus 1-associated kaposi's sarcoma--drug-drug interactions with protease inhibitors and a nonnucleoside reverse transcriptase inhibitor: a case report study. | to describe the pharmacokinetics of paclitaxel and to investigate the interaction potential with protease inhibitors (indinavir, ritonavir, saquinavir) and the nonnucleoside reverse transcriptase inhibitor nevirapine, for which strong theoretical indications for clinically relevant drug interactions exist. | 1999 | 10321513 |
| kaposi's sarcoma-associated herpesvirus infection in the lung in multicentric castleman's disease. | a 32-year-old female was admitted for evaluation of multiple infiltrates on a chest radiograph. a diagnosis of multicentric castleman's disease was made on the basis of typical clinical manifestations. transbronchial lung biopsy (tblb) revealed histological findings reported in lymphocytic interstitial pneumonia. both the polymerase chain reaction and in situ hybridization with a probe specific for kaposi's sarcoma-associated herpesvirus (kshv) sequences demonstrated the presence of kshv in the ... | 1999 | 10337942 |
| human herpes virus-8 and other risk factors for kaposi's sarcoma in kidney transplant recipients. groupe cooperatif de transplantation d' ile de france (gcif). | the exact reasons for the high incidence of kaposi's sarcoma (ks) after kidney transplantation are still unknown. immunosuppression is classically considered as the main risk factor, but the relative risk contributed by the patient's geographic origin and by human herpes virus (hhv)-8 infection still has to be determined. | 1999 | 10342315 |
| the role of kaposi's sarcoma-associated herpesvirus (kshv/hhv-8) in lymphoproliferative diseases. | the kaposi's sarcoma-associated herpesvirus (kshv), also called human herpesvirus 8 (hhv-8), has been found to be present in a limited subset of lymphoproliferative disorders. among these are the primary effusion lymphomas, formerly designated body cavity-based lymphomas, a rare type of malignant lymphoma which possesses an unusual set of clinical and biologic features, suggesting that they represent a distinct disease entity. this virus is also present in a large proportion of cases of multicen ... | 1999 | 10343068 |
| the descent of human herpesvirus 8. | analysis of conserved herpesvirus genes shows that human herpesvirus 8 (hhv8) belongs to a clade of primate herpesviruses within the gamma2 sublineage. overall, this clade has developed by cospeciation with host species. seventeen genes of hhv8 and its nearest relatives lack simple homologues in other herpesviruses, and eight of these have known mammalian homologues, presumed to be the sources of the hhv8 versions. comparative analyses yield further insights into the source or time of acquisitio ... | 1999 | 10343071 |