Publications

restriction endonuclease cleavage maps of rat and mouse mitochondrial dnas.	mitochondrial dna from an old world mouse, mus musculus, and from an old world rat, rattus norvegicus, contain 19 and 22 distinct sites, respectively, for the 8 restriction endonucleases, bamhi, ecori, haeii, hhai, hincii, hindiii, hpai and psti. the relative positions of the sites have been mapped by the study of partial and double enzyme digests. some sites may been conserverd between the mouse and rat mitochondrial genomes.	1977	331254
detection of haemophilus influenzae type b antigens in body fluids, using specific antibody-coated staphylococci.	protein a-rich staphylococci coated with haemophilus influenzae type b antiserum agglutinate specifically with homologous bacterial cells or with cell-free supernatant fluids of cultures of the organism. antibody-coated staphylococci were used to detect soluble antigens in body fluids of patients infected with h. influenzae type b. cerebrospinal fluid from 36 cases of meningitis caused by this orgainsm showed positive coagglutination tests in 86% of patients prior to initiation of therapy. antig ...	1977	319113
genetic effects of nitrous acid.		1977	325396
[drug sensitivity of haemophilus sp. and transfer of resistance into e. coli (author's transl)].	from june 1973 to july 1976, 742 strains of haemophilus influenzae and parainfluenzae, isolated from clinical specimens, were routinely tested for in vitro sensitivity to twelve antibiotics: penicillin, ampicillin, cephalothin, streptomycin, kanamycin, gentamicin, chloramphenicol, tetracyclin, minocyclin, erythromycin, sulfamethoxazol, trimethoprim. 61 strains were found resistant to one or more of these antibiotics (ampicillin, kanamycin, chloramphenicol and tetracyclin). the mics of 23 antibio ...	1977	327413
separation of the complementary strands of dna fragments on polyacrylamide gels.	32p-labeled (in vivo) phix174 rfi dna was restricted by hinc ii. three aliquots of the same digest: a) nondenatured, b) heat denatured, and c) denatured by 5 mm me-hgoh were analyzed on 3-15% acrylamide gel gradients or on 3% gels with reduced n,n'-methylene-bis-acrylamide. the autoradiography of the gels showed that the nondenatured sample migrates two times faster than the denatured samples. after denaturation each original fragment appeared as a doublet. using in vitro synthesized rfi dna lab ...	1977	331258
a double-blind comparative study of ampicillin, co-trimoxazole and josamycin in anthraco-silicotic miners, assessed by transtracheal puncture.		1977	332681
positions of sea urchin (strongylocentrotus purpuratus) histone genes relative to restriction endonuclease sites on the chimeric plasmids psp2 and psp17.	the positions of the several sea urchin histone genes on the eukaryotic fragments of the chimeric plasmids psp2 and psp17 have been mapped relative to the eco ri and hind iii restriction endonuclease sites on the plasmids. two principal mapping methods using the electron microscope have been used: (a) the r-loop procedure and a new modification thereof to map the genes on duplex dna; (b) the gene 32-ethidium bromide technique to visualize rna-dna hybrids on single strands of dna. it is known tha ...	1977	321020
characterization of distinct segments in mouse satellite dna by restriction nucleases.	the long-range periodicity of mouse satellite dna has been analyzed by digestion with five restriction nucleases. with all nucleases tested, a major repeat unit approximately 245 nucleotide pairs became apparent. minor registers of shorter length were also detected. the total number of cleavage sites per haploid genome for each restriction enzyme as well as their positions relative to each other were determined. while endo r-ecorii was known to cleave all of the satellite dna, the other four res ...	1977	321221
a comparative study on the humoral immune responses in germ-free and conventional mice.	the plaque-forming cell (pfc) responses to sheep red blood cell (srbc) dinitrophenyl-lysine-ficoll (dnp-lys-ficoll), and dinitrophenylated bovine serum albumin (dnp-bsa) have been studied in both germ-free and conventionally reared icr mice. in germ-free mice, the igg response to srbc and the igm and igg responses to dnp-bsa were lower than in conventional mice, but no difference was observed in the igm response to srbc or the igm and igg responses to dnp-lys-ficoll. further, the number of 0-bea ...	1977	321340
the germicidal effect of the open air in different parts of the netherlands.	using the microthread technique the survival of escherichia coli mre 162 in open air was measured in different parts of the netherlands. the presence of bactericidal compounds (open air factor = oaf) could be demonstrated on several days and quantitated in relative units of oaf concentration. in the absence of ozone the oaf concentration was always low. in the presence of ozone the oaf concentration was dependent on wind direction. at the selected microthread exposure sites air from areas with h ...	1977	321676
alteration of free serum amino acids in voles infected with trypanosoma brucei gambiense.	free serum amino acid pools of field voles, microtus montanus, were determined over a 24 hr period, and compared to values obtained from voles infected with trypanosoma brucei gambiense. the majority of amino acids in the control animals demonstrated a diurnal variation, peaking predominantly during the dark portion of the photoperiod. this trend was not evident in the infected animals. in addition, infected voles possessed an apparent state of hypoaminoacidemia, with levels of threonine, serine ...	1977	321737
haemophilus parainfluenzae and influenzae endocarditis: a review of forty cases.	two cases of bacterial endocarditis caused by haemophilus parainfluenzae are reported with a review of 33 other cases of h. parainfluenzae endocarditis and 5 cases of h. influenzae endocarditis. although h. parainfluenzae is usually considered a non-pathogenic microorganism, this review firmly establishes its role as a causative agent in endocarditis. furthermore, several clinical features were noted which were atypical when compared to findings usually present in patients with bacterial endocar ...	1977	321916
detection and quantitation of bacteremia in childhood.	quantitative blood cultures were sought in 383 children, from whom routine blood cultures were obtained because of fever, by direct plating of 10 and 100 microliter blood onto solidified media. there were 14 positive cultures from 12 patients. these were 7 hemophilus influenzae type b, 5 streptococcus penumoniae, and 2 staphylococcus aureus. the direct-plating technique permitted more rapid identification of positive cultures, and detected three episodes not identified by routine broth culture. ...	1977	333075
packaging recombinant dna molecules into bacteriophage particles in vitro.	recombinant phage genomes made in reactions with purified enzymes may be recovered directly by packaging into phage heads in vitro. the process is efficient and nonselective and offers containment in initial stages of handling recombinant dna. ligase [poly(deoxyribonucleotide):poly-(deoxyribonucleotide) ligase (amp-forming), ec 6.5.1.1] reaction products can recombine with endogenous phage dna during packaging, but uv-irradiation eliminates the biological activity of the endogenous dna.	1977	333431
[quantitative studies of yeast in the sputum of patients with chronic bronchitis under long-term observation].		1977	335241
nursing care study: haemophilus influenzae meningitis.		1977	840674
serum immunoglobulin levels in the course of bacterial meningitis in children.	serum levels of 5 immunoglobulins (igg, iga, igm, igd and ige) were determined at frequent intervals in the course of bacterial meningitis in children. 59 patients were examined; 27 with haemophilus influenzae meningitis, 23 with meningococcal and 9 with pneumococcal meningitis. all 5 immunoglobulins increased during the 2-week course of bacterial meningitis. igm was the immunoglobulin class responding most rapidly, regularly and intensively. igg increased moderately. however, practically no ris ...	1977	841276
[the influence of the permeability of the cell membrane on tmpd oxydase activity (author's transl)].	26 bacterial strains representing a variety of both gram-negative and gram-postive groups were investigated for their n,n,n',n'-tetramethyl-1, 4-phenylendiamin (tmpd) oxidase activities and cytochrome contents. the oxidase activites of colonies were examined by dropping the reagent on agar surface colonies. intact and sonicated cells were tested by recording the oxidation of the tmpd reagent at 546 nm after addition to the cell suspensions. cytochromes were determined by recording the difference ...	1977	848217
acute epiglottitis in adults.	nine cases of acute epiglottitis in adults, seen over a period of ten years, are presented. the presence of severe pain and dysphagia as universal presenting features are stressed, and the frequent absence of pharyngeal injection is noted. we found that the disease in adults differs from that in children in that pain and dysphagia are more marked, that stridor is a less prominent feature, and that haemophilus influenzae appears not to be the sole causative organism.	1977	853252
penetration of cefazolin into pleural fluid.	single doses of cefazolin, 500 mg intramuscularly and 1 g intravenously, were administered to 16 patients having lung pathology who were scheduled for thoracic fluid aspiration. pleural fluid and serum samples were taken at intervals of 30 to 240 min for determination of cefazolin levels. the levels obtained were variable; however, the levels of cefazolin in pleural fluid generally exceeded the reported minimal inhibitory concentration values for staphylococcus pneumoniae and staphylococcus, and ...	1977	879748
penetration of cefamandole into spinal fluid.	twelve patients, aged 6 months to 62 years, with proven bacterial meningitis, were given a single intravenous dose of cefamandole (33 mg/kg) 75 to 140 min before a routine lumbar puncture. infecting organisms included haemophilus influenzae (eight cases), streptococcus pneumoniae (two cases), and neisseria meningitidis and beta-hemolytic streptococcus (one each). cerebrospinal fluid (csf) was analyzed by microbiological assay for cefamandole. the median concentration was 0.60 mug/ml, ranging fro ...	1977	879759
tetracyclines, chloramphenicol, erythromycin, and clindamycin.	tetracyclines are active in vitro against most urinary tract pathogens, chlamydia, mycoplasma pneumoniae, brucella, rickettsiae, and nocardia. chloramphenicol is used primarily for anaerobic infections, haemophilus influenzae meningitis, and infections due to salmonella typhi. erythromycin is active in vitro against m. pneumoniae, streptococcus pneumoniae, and group a beta-hemolytic streptococci. erythromycin may be used as prophylactic therapy for subacute bacterial endocarditis and for recurre ...	1977	909315
early detection and preliminary susceptibility testing of positive pediatric blood cultures with the steers replicator.	early replicator subculturing of blood specimens after 4 to 16 h of incubation detected 135 of 217 (59%) of all positive cultures, including 56 of 64 (87%) haemophilus influenzae type b, 7 of 22 (32%) staphylococcus aureus, 19 of 20 (95%) pathogenic streptococci, and 20 of 24 (83%) enterobacteriaceae. the mean time to detection of the common pediatric pathogens (36 h) was significantly less than that of contaminants (85 h) (p less than 0.001). blind subculturing to differential media aided in th ...	1977	914993
latex agglutination in diagnosis of bacterial infections, with special reference to patients with meningitis and septicemia.	antibody-sensitized latex particles were used to demonstrate specific bacterial antigens in cerebrospinal fluid, blood and urine. difficulties with reported nonspecific agglutinations appear to have been overcome. the method seems to be sensitive, specific, and simple to perform, and shows a better detection rate than culture or countercurrent immunoelectrophoresis. urinary excretion of haemophilus influenzae antigens was followed. the diagnostic usefulness of demonstrating such antigens at a la ...	1977	879103
in vitro studies with cefaclor, a new oral cephalosporin.	in vitro studies were performed to evaluate the activity of cefaclor in comparison with cephalexin against 180 clinical isolates. broth dilution susceptibility tests showed cefaclor to be 4- to 16-fold more active than cephalexin against streptococcus pneumoniae, haemophilus influenzae, and cephalothin-susceptible enterobacteriaceae. neither drug was highly active against cephalothin-resistant enterobacteriaceae or methicillin-resistant staphylococcus aureus. cefaclor zones with 30-mug disks wer ...	1977	921244
[role of haemophilus influenzae and diplococcus pneumoniae in the development of exacerbations of chronic bronchitis].		1977	917917
bacterial meningitis in southwestern alaska.	between july 1, 1971, and june 30, 1974, thirty-nine cases of bacterial meningitis were diagnosed at the alaska native health service hospital at bethel, alaska. thirty-two (82%) occurred in infants less than one year of age. haemophilus influenzae (h. influenzae) was the predominant causative agent, and was isolated from 23 (72%) of the 32 patients under one year of age. the annual incidence of h. influenzae meningitis in the bethel area was 63/100,000, and the annual incidence of h. influenzae ...	1977	920727
a review of public hospital nursing staff levels.		1977	274615
[comparative studies on the precision fit of mandibular total prostheses with plastic and with metal bases from a technological viewpoint].		1977	352016
effects of diltiazem on complications and restenosis after coronary angioplasty.	a randomized, placebo-controlled, double-blinded trial was performed to evaluate the usefulness of empiric therapy with a calcium antagonist in patients who undergo coronary angioplasty. a total of 201 patients were randomized to placebo or to high-dose diltiazem (mean dose, 329 mg/day). treatment began 24 hours before angioplasty. restenosis was assessed by percent area stenosis as determined by quantitative angiographic techniques before, immediately and 1 year after angioplasty. all patients ...	1977	1994661
["mercedes-benz-sign" or "jack stone" of gallstones (author's transl)].		1977	421279
preventing endocarditis.		1977	421085
[evaluation of internally effective venous drugs].		1977	351993
pancreatitis during combination chemotherapy.		1977	421389
control of occupational exposure to nitrous oxide in the oral surgery office.	occupational exposure to inhalation anesthetics can be substantially reduced by control measures that have been recently developed. the incentive for their use should be the suspected relationship between chronic exposure to trace concentrations of agents, such as nitrous oxide, and health hazards. control measures include the use of a newly developed scavenging nasal mask, relatively gastight anesthetic equipment, and vented suction machine, supported by an air monitoring program. with these me ...	1977	274530
lung cancer etiology. critical appraisal.		1977	274630
a method for determining patients' perceptions of their health needs.	success or failure in establishing a meaningful relationship between physician and patient depends to a large extent on how fully the patient communicates, and the physician understands, his/her health needs. return visits, compliance with the physician's prescribed regimen, and the effectiveness of the treatment and rehabilitation are also closely related to the disclosure and assessment of the patient's health needs. a model of how health needs are determined is presented. various behavioral o ...	1977	429998
[invention patents and their role in dentistry].		1977	274776
caffeine in sport. influence of endurance exercise on the urinary caffeine concentration.	this study was conducted to evaluate the influence of excessive sweating during long-distance running on the urinary concentration of caffeine after the intake of a large amount of caffeine. nine endurance-trained athletes participated in a randomised cross-over study in which 450 mg caffeine were taken with and without exercise. exercise consisted of running for 30 min on a treadmill at 75% of maximum heart rate, one hour after intake of caffeine. this endurance exercise caused a decrease in th ...	1977	1544739
necrolytic migratory erythema, presenting as candidiasis, due to a pancreatic glucagonoma.	a 54-year-old male with diabetes, weight loss, glossitis and candidiasis presented with the typical cutaneous eruption of necrolytic migratory erythema. the suspicion of pancreatic glucagonoma was confirmed by an elevated plasma glucagon level. surgical removal of the pancreatic alpha cell tumor resulted in a complete disappearance of all symptoms. the importance of the recognition of the skin eruption of necrolytic migratory erythema as a clue to the presence of pancreatic glucagonoma is emphas ...	1977	476569
symptomatic cluttering in adults.		1977	476473
pharmacokinetics of antiarrhythmic drugs.	a knowledge of the determinants of the plasma concentrations of antiarrhythmic drugs is important because variation in plasma levels is often greater than the desired therapeutic range. the basic principles of pharmacokinetics are outlined and their application to the design of dosage regimens described. these principles are illustrated in a review of the pharmacokinetics of lidocaine and its congeners, procainamide and its active metabolite (n-acetylprocainamide), quindine, disopyramide, phenyt ...	1977	352124
childhood sexual experiences with adults reported by female psychiatric patients.	a group of 115 female psychiatric in-patients and out-patients were studied, using a self-report questionnaire followed by interview, for evidence of childhood sexual activity with adults. about half of the sample reported some childhood sexual experience, ranging from full sexual intercourse to sexual suggestions. future research should study the possible role of such experience in the genesis of subsequent psychiatric disorder.	1977	1540767
the grumbling appendix.		1977	476432
respiratory distress and hypoxemia in systemic mastocytosis.	a 25-year-old woman with documented mastocytosis developed hypoxemia with pruritus, diarrhea, headache, and hypotension on two separate occasions. the hypoxemia appeared to be related to a massive release of histamine. resolution of the patient's symptoms was accompanied by the return of her arterial oxygen tension to normal levels.	1977	421534
lidocaine for quinidine-induced ventricular arrhythmias.		1977	421511
[comparison of three serological methods for determination of antistreptokinase following fibrinolytic therapy (author's transl)].	by means of three different reactions, precipitation, passive haemagglutination and the determination of antifibrinolytic antibodies the formation of streptokinase antibody after streptokinase treatment was investigated. the earliest antistreptokinase we found with the passive haemagglutination reaction at day 4 on the beginning of streptokinase therapy. precipitating and antifibrinolytic antibodies were found at day 7. one patient did not develope precipitating, an other formed no haemagglutina ...	1977	352035
[dental impressions with hydrocolloids].		1977	352020
[presentation of the statokinesimeter ela].		1977	1008166
false ascites in a patient with leveen shunt detected by intraperitoneal injection of 99mtc-sulfur colloid.		1977	421392
[in memoriam col. med. corps, aleksandar mitić, m.d].		1977	351941
ewing sarcoma of the mandible: report of case.	a case of ewing sarcoma, primarily localized in the mandible in a 19-year-old woman, is reported. the case report covers the initial symptoms, which are often misleading, the history, clinical, radiographic, and histologic features; and the treatment by surgery complemented with radiotherapy and chemotherapy.	1977	274536
food loss and cost control.		1977	234889
[consumption of health care in persons above 80 years of ago].		1977	421296
[differential diagnostic considerations in otalgia].		1977	351977
[on the phenotypical characteristics of haemophilus isolates from human respiratory tract (author's transl)].	50 strains of hemophilic bacteria from the human upper respiratory tract were studied using morphological, physiological, and biochemical features including respiratory quinones. the isolates were associated with the conventional species haemophilus influenzae, h. parainfluenzae and h. aegyptius. they were grouped into the proposed biovarieties of the influenzae- and parainfluenzae-groups according to kilian's classification. the heterogeneous group of aegyptius-strains was not classified in det ...	1978	749417
clinical and laboratory investigation of cefamandole therapy of infections in infants and children.	cefamandole nafate was effective in the treatment of a variety of infections caused by staphylococcus aureus, streptococcus pyogenes group a, streptococcus pneumoniae, and haemophilus influenzae in infants and children. the infections included periorbital cellulitis and ethmoiditis, bacteremia, cellulitis, pneumonia, and lymphadenitis. in vitro, cefamandole was effective in inhibiting the growth of h. influenzae isolated from blood or cerebrospinal fluid of patients with meningitis or sepsis. in ...	1978	349094
antibacterial activity of cefamandole in vitro.	cefamandole, a new cephalosporin derivative, was found to have a broad spectrum of antimicrobial activity against a cross-section of both gram-positive and gram-negative bacteria isolated clinically. gram-positive cocci, except for streptococcus faecalis, were extremely susceptible to cefamandole; penicillin g-resistant staphylococcus aureus also was highly susceptible. minimal bactericidal concentrations for gram-positive cocci approximated the minimal inhibitory concentrations. strains of haem ...	1978	349095
acid precipitation of clostridium botulinum type c and d toxins from whole culture by addition of ribonucleic acid as a precipitation aid.	the ratios of ribonucleic acid to protein contents of clostridium botulinum type c, d, and e cultures were lower than those of type a, b, and f cultures. addition of ribonucleic acid at 0.4 mg/ml to culture satisfactorily aided acid precipitation of type c and d toxins, but not that of type e toxin.	1978	344224
a rapid slide test for penicillinase.	the authors developed a rapid slide test modification of the iodometric method for detection of penicillinase produced by organisms growing on routine plating media. a loopful of colonies is scraped from the agar surface and emulsified in one drop of an iodine-penicillin solution on a glass slide. addition of a drop of 0.4% starch solution results in a purple color when penicillinase is not present; a colorless reaction denotes a positive test. the slide test yielded positive results identical t ...	1978	345799
restriction endonucleases and modification methylases in bacteria.		1978	346412
qualitative study of paradoxical zone phenomenon of penicillins against 17 bacterial species of clinical importance.	using a triple agar layer technique and enzymatic inactivation of penicillin, the occurrence of a paradoxical zone phenomenon (illustrated by a typical 'target' image around the reservoir of antibiotic) was determined for several bacterial species specially chosen with regards to their taxonomic position, clinical importance and penicillin susceptibility. among gram-positive bacteria, a paradoxical zone was obtained for approximately 43% of the strains studied here (all 10 strains of staphylococ ...	1978	340171
utility scaling of intracranial reinforcement duration.		1978	311015
experimental and clinical immunopathology of middle ear transplantation.	on the basis of experimental data the concept of immuno-tolerance in allograft-tympanoplasty is discussed. immunological interference in human tympanic membrane grafts has been demonstrated by means of t-cell membrane fluorescence.	1978	310740
characterization of lipopolysaccharide of haemophilus influenzae.	lipopolysaccharide from strains of haemophilus influenzae was extracted and isolated by the hot phenol-water procedure. the preparations were relatively insoluble in water but could be solubilized with surface-active agents. the preparations contained carbohydrate (30%), fatty acid (29%), and phosphate (4.7%); protein content was less than 1%. thin-layer chromatography, gas-liquid chromatography, and colorimetric assays detected glucose, galactose, glucosamine, heptose, and a 2-keto-3-deoxy-octo ...	1978	310855
human mucosal lymphocytes - memory for 'recall' antigens and non-specific suppression by t-lymphocytes.		1978	311142
[the influence of cryoprotective solutions on the ultrastructure of rabbit corneal endothelium (author's transl)].	a series of rabbit corneae was preserved at -196 degrees c in liquid nitrogen using five different cryoprotective solutions: (1) 5% dextran t 40, (2) 10% polyvinylpyrrolidone, (3) 5% dextran t 40 + 10% polyvinylpyrrolidone + dimethyl sulfoxide, (4) 25% rabbit albumin + 10% polyvinylpyrrolidone, (5) 25% rabbit albumin + dimethyl sulfoxide. after thawing the corneae, the influence of the different cryoprotective solutions on the ultrastructure of corneal endothelium was evaluated and compared with ...	1978	311165
further studies on the immunology of the infant rat experimental model of haemophilus influenzae type b meningitis.		1978	309766
the role of pre-replication and post-replication processes in mutation induction in haemophilus influenzae by n-methyl-n'-nitro-n-nitrosoguanidine.	studies were carried out on the repair and fixation of premutational damage induced in haemophilus influenzae by n-methyl-n'-nitro-n-nitrosoguanidine (mnng). the studies employed a temperature-sensitive dna elongation mutant (dna9) and its combinations with mutants defective in pyrimidine dimer excision (uvr1, uvr2) and in recombination (rec1). the dna9 mutant is shown to be leaky, allowing about 1% of the normal rate of dna synthesis at the restrictive temperature. repair of premutational lesio ...	1978	310510
occurrence of haemophilus epiglottitis.		1978	306191
haemophilus influenzae type b infections.		1978	306192
haemophilus influenzae type b osteomyelitis.	three children had osteomyelitis due to haemophilus influenzae type b. they were seen with signs and symptoms indistinguishable from infection caused by other organisms. one child was initially misdiagnosed as having septic arthritis because of failure to appreciate that hemophilus may also cause bone infection. in the second patient osteomyelitis and arthritis developed during ampicillin sodium therapy for treatment of hemophilus meningitis. his initial infection was caused by an ampicillin-sen ...	1978	306193
acidometric agar plate method for ampicillin susceptibility testing of haemophilus influenzae.	the need for an accurate and rapid method of testing ampicillin susceptibility of haemophilus influenzae, especially strains isolated from patients with meningitis and septicemia, is indisputable. various methods have been employed for this purpose. each has advantages and disadvantages. this report describes a modification of the capillary acidometric procedure in which an agar plate is substituted for a tube. all beta-lactamase results obtained by this modified technique correlated with minima ...	1978	306220
diagnosis of haemophilus influenzae type b pericarditis by counterimmunoelectrophoresis.	a 6-year-old girl developed pericardial tamponade because of pericarditis caused by haemophilus influenzae type b. bacteriological cultures of the pericardial exudate were negative. the etiological diagnosis was established by counterimmunoelectrophoresis (cie).	1978	307808
comparative activities of selected beta-lactam antibiotics against haemophilus influenzae.	the comparative activities of ampicillin, cefamandole, cefoxitin, cefaclor, and cefatrizine against both beta-lactamase-producing and non-beta-lactamase-producing isolates of haemophilus influenzae were determined by using an agar dilution susceptibility test procedure. ampicillin was the most active drug tested against non-beta-lactamase-producing isolates, whereas cefamandole was most active against beta-lactamase-producing strains.	1978	306221
haemophilus influenzae type b pneumonia.	thirteen patients with haemophilus influenzae type b pneumonia are reported to emphasise the clinical, radiographic, and therapeutic aspects of this illness. all but one patient was under 2 1/2 years of age. the presenting complaint was a variable duration of upper respiratory infection and fever in most cases. one-third of patients had radiographic evidence of pleural involvement; one-third showed a patchy bronchopneumonia on roentgenogram; and the remainder had segmental or lobar infiltrates. ...	1978	306225
clinical and laboratory evaluation of cefamandole in infants and children.	fifty-three infants and children, aged three months to 15 years, were treated with an average daily dose of 100 mg of cefamandole/kg intravenously. of these patients, 47 had soft tissue cellulitis and six had pneumonia. primary pathogens, including staphylococcus aureus, streptococcus pyogenes, streptococcus pneumoniae, and haemophilus influenzae, were isolated from 43 of the 53 patients. bacteremia was documented in six of the 53 patients. a satisfactory clinical and bacteriologic response to c ...	1978	306402
failure of cefamandole in treatment of meningitis due to haemophilus influenzae type b.	the in vitro activity of cefamandole was determined against 58 isolates of haemophilus influenzae type b; 47 were beta-lactamase-negative (ampicillin-susceptible), and 11 produced beta-lactamase (ampicillin-resistant). ampicillin-susceptible strains were susceptible to cefamandole with a median minimal bactericidal concentration (mbc) of 0.4 microgram/ml. ampicillin-resistant strains had a median mbc of 0.8 microgram/ml. prior studies have documented these concentrations of cefamandole in cerebr ...	1978	306403
rapid diagnosis of hemophilus influenzae type b infections by latex particle agglutination and counterimmunoelectrophoresis.	latex particle agglutination and counterimmunoelectrophoresis techniques were compared in a clinical trial to demonstrate their sensitivity, specificity, and usefulness in the rapid diagnosis of invasive hemophilus influenzae type b disease. lpa, a simplified lpa performed by house officers, and cie used in this study detected 0.2, 0.5, and 1 to 10 ng/ml of hib capsular antigen, respectively. one hundred-six illnesses suspected of being caused by hib were evaluated prospectively by these assays. ...	1978	306427
haemophilus influenzae bacteremia and meningitis resulting from survival of a single organism.	infant rats were infected intranasally with mixtures of streptomycin-sensitive and streptomycin-resistant strains of haemophilus influenzae type b and cultures of nasopharyngeal washings, blood, and cerebrospinal fluid were obtained. if the infecting organisms cooperated with each other during the establishment of infection, nasopharyngeal, blood, and cerebrospinal fluid cultures should have contained mixtures of the variants. if each organism acted independently, then with small infecting inocu ...	1978	306628
hearing disorders after haemophilus influenzae meningitis. comparison of different drug regimens.	of 131 children with bacteriologically verified haemophilus influenzae meningitis, 75 were treated with ampicillin sodium and 45 with a combination of chloramphenicol, sulfonamides, and penicillin g sodium during the first 72 hours. audiological and neuro-otologic examinations performed 1 to 15 years later showed that 3 patients were totally deaf, 11 had moderate and 15 minimal hearing losses, and 6 had vestibular disorders. all three deaf children and all those with recognized vestibular disord ...	1978	306816
haemophilus influenzae infections.		1978	309718
radiological case of the month.		1978	309719
bacteremic haemophilus influenzae genitourinary tract infections in adults.	six cases of bacteremia associated with genitourinary (gu) tract infections in adults due to haemophilus influenzae occurred during a 42-month period at the health sciences centre in winnipeg, canada. four cases were associated with pregnancy or abortion, one with acute salpingitis, and one with urinary tract manipulation. four of the five strains available for serotyping were nontypable. clinical conjunctivitis was present in one patient, and infants born to two other patients developed purulen ...	1978	309754
treatment of otitis media caused by hemophilus influenzae: evaluation of three antimicrobial regimens.	ninety young children with otitis media, proven by tympanocentesis culture to be due to hemophilus influenzae, were treated in a prospective double-blind study with one of three antimicrobial regimens: ampicillin, erythromycin ethylsuccinate, or erythromycin ethylsuccinate with concomitant trisulfapyrimidines. results of efficacy evaluation indicated that the combination was as effective as ampicillin and statistically superior to erythromycine alone. of the strains of h influenzae identified, 1 ...	1978	310164
clavulanic acid, a novel inhibitor of beta-lactamases.	clavulanic acid, z-(2r,5r)-3-(beta-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo-[3,2,0] heptane-2-carboxylic acid, has been shown to be an effective inhibitor of the beta-lactamases of the richmond types ii, iii, iv, and v. inhibition is a time-dependent reaction and is irreversible. clavulanic acid had poor antibacterial activity against staphylococcus aureus, enterobacteriaceae, and pseudomonas aeruginosa, with minimal inhibitory levels greater than 25 mug/ml. it did inhibit the majority of nei ...	1978	310279
minimum bactericidal concentration of sulfamethoxazole-trimethoprim for haemophilus influenzae: correlation with prophylaxis.	the inability of sulfamethoxazole-trimethoprim (sxt) to eradicate haemophilus influenzae nasopharyngeal carriage in all asymptomatic patients in closed populations was examined in vitro. a broth medium was adapted for susceptibility testing of h. influenzae which permitted us to determine minimum inhibitory concentrations and minimum bactericidal concentrations (mbcs). the minimum inhibitory concentrations were all low, but the mbcs were bimodally distributed. trimethoprim alone or the combinati ...	1978	310281
adult haemophilus influenzae type b vertebral osteomyelitis: a case report and review of the literature.	osteomyelitis in adults due to haemophilus influenzae is exceedingly rare. we report a case of h. influenzae type b vertebral osteomyelitis in an adult. review of the english literature reveals one other adult patient with h. influenzae osteomyelitis, and sporadic pediatric cases. although a variety of predisposing host resistance factors have been postulated to account for this infection, the deficiency responsible for adult infection remains undelineated. bone biopsy is mandatory for diagnosis ...	1978	310376
enzyme-linked immunosorbent assay for detection and quantitation of capsular antigen of haemophilus influenzae type b.	an enzyme-linked immunosorbent assay was developed to detect the presence of the ribose-ribitol phosphate capsular antigen of haemophilus influenzae type b in laboratory and clinical specimens. the assay is simple, sensitive, specific, and quantitative and should prove to be of value in the diagnosis and management of h. influenzae infections.	1978	310425
[haemophilus influenzae antibodies in the body fluid].		1978	310481
[development of haemophilus influenzae in culture media].		1978	315604
on the nature of nontypable haemophilus influenzae.	193 haemophilus cultures, including 71 nontypable h. influenzae isolates, were examined with respect to phage hp1 sensitivity, lysogeny for this and for other phages and for excretion of bacteriocins. fifty of the 71 nontypable cultures were sensitive to phage hp1 but only three produced plaques. the other 47 isolates were thus probably not non-encapsulated derivatives of h. influenzae serotypes a, b, d, and e, which have discrete and characteristic phage hp1 restriction and modification systems ...	1978	313183
cortical blindness associated with occipital atrophy: a complication of h. influenzae meningitis.		1978	308472
earache and coma.		1978	308490
cefotoxime (hr 756) a new cephalosporin with exceptional broad-spectrum activity in vitro.		1978	308505
activity of hr 756 against haemophilus influenzae, bacteroides fragilis and gram-negative rods.		1978	308506
synchronous division and rates of macromolecular synthesis in haemophilus influenzae competent for genetic transformation.	when competent haemophilus influenzae were returned to complete growth medium, they resumed growth at once and underwent a synchronous division after 20 to 25 min. the rate of dna synthesis increased to the definitive rate very quickly after resumption of growth. in contrast, the rate of rna synthesis remained low until the time of division, at which time it accelerated dramatically. changes in the rate of protein synthesis were similar in form to those of rna synthesis. the kinetics of loss of ...	1978	308508
effect of tmp-smx on nasopharyngeal carriage of ampicillin-sensitive and ampicillin-resistant hemophilus influenzae type b.	the carriage rate of ampicillin-resistant hemophilus influenzae type b in a chronic care facility was investigated. up to 48% of the children carried this strain. of interest was the finding of simulaneous carriage of ampicillin-resistant and ampicillin-sensitive hitb, a phenomenon which was detected by using both chocolate agar and chocolate agar containing 2 microgram/ml of ampicillin. a trial of sulfamethoxazole-trimethoprin successfully eradicated the ampicillin-sensitive hitb, but had no ef ...	1978	308533
periorbital cellulitis in children.		1978	309105
acute glossitis due to hemophilus influenzae type b.		1978	308534