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schönlein-henoch purpura associated with gastric helicobacter pylori infection.schönlein-henoch purpura is characterized by palpable purpura, colicky abdominal pain, gastrointestinal hemorrhage, arthralgias, and renal involvement. bacterial and viral infections, as well as drugs and diseases associated with immune complexes, are thought to be responsible. we describe the case of a 21-year-old woman with schönlein-henoch purpura and chronic active gastritis with erosions. helicobacter pylori was found in gastric mucosa using the newly introduced, nontoxic, noninvasive 13c-u ...19957593800
serodiagnosis of helicobacter pylori infection by enzyme-linked immunoelectrotransfer blot. gastrointestinal physiology working group of cayetano heredia university.immunoreactive bands in sera from 81 peruvian adults (48 females and 33 males) aged between 18 and 85 years were detected using enzyme-linked immunoelectrotransfer blot with a glycine-extracted helicobacter pylori antigen. sensitivity and specificity of bands were determined by comparison with results of h. pylori obtained by culture and silver stain of gastric biopsies. a crude antigen and a commercial enzyme-linked immunosorbent assay (pylori stat, whittaker) were also evaluated for their diag ...19957594313
suppression of acid secretion by lansoprazole and its effects on helicobacter pylori. ii. poster presentations from the 2nd international colloquium on proton pump inhibitors. houston, texas, september 29, 1994. 19957594319
gastric ulcer healing and basic fibroblast growth factor: effects of lansoprazole and famotidine.we examined the effects of lansoprazole and famotidine on gastric basic fibroblast growth factor (bfgf) levels and ulcer healing in patients with gastric ulcer. sixteen patients with active gastric ulcer were divided into two groups and received treatment with lansoprazole 30 mg/day or famotidine 40 mg/day. they were examined endoscopically at 2, 4, and 8 weeks to measure gastric bfgf levels at the ulcer margin and to assess ulcer healing. helicobacter pylori infection was determined by a rapid ...19957594320
clinical efficacy of lansoprazole-amoxicillin treatment in eradicating helicobacter pylori: evaluation by the polymerase chain reaction method.the clinical efficacy of lansoprazole plus amoxicillin treatment in eradicating helicobacter pylori was examined in peptic ulcer patients. h. pylori eradication was assessed by the polymerase chain reaction (pcr) method in addition to conventional methods. fifteen h. pylori-positive patients with active peptic ulcers (10 duodenal ulcer patients and 5 gastric ulcer patients) were given lansoprazole 30 mg/day from day 1 to day 56 and amoxicillin 1,500 mg/day from day 15 to day 28. four weeks after ...19957594321
lansoprazole versus lansoprazole plus amoxicillin treatment for eradication of helicobacter pylori in patients with gastric ulcer.helicobacter pylori is a major cause of gastritis and an important factor in duodenal ulcer relapse. eradication of h. pylori has usually been achieved by triple therapy, a combination of bismuth salts and two antibiotics. the disadvantage of these regimens is the large number of tablets and the high incidence of side effects. a new h+,k(+)-atpase inhibitor, lansoprazole (lpz), has a strong acid inhibitory effect and an anti-h. pylori effect in vitro. these dual effects have an advantage for the ...19957594322
effects of lansoprazole with or without amoxicillin on ulcer healing: relation to eradication of helicobacter pylori.we studied the effects of lansoprazole with or without amoxicillin on the quality of ulcer healing in relation to eradication of helicobacter pylori. ulcer healing rates for lansoprazole 30 mg q.d. alone (group a) were 100% for duodenal ulcers (du; n = 20) and 92% for gastric ulcers (gu; n = 15). the healing rates for lansoprazole 30 mg plus amoxicillin 1-2 g q.d. (group b) were 100% for both du (n = 20) and gu (n = 12). endoscopic findings after treatment showed that the red scar/white scar rat ...19957594323
clinical efficacy of lansoprazole in eradication of helicobacter pylori.a randomized, single-blind study was designed to assess the effect of lansoprazole alone and lansoprazole plus amoxicillin on the healing and eradication rates in helicobacter pylori-associated peptic ulcer disease. seventy-nine patients with gastric ulcers and 54 patients with duodenal ulcers were randomly assigned to two treatment groups. group 1 received lansoprazole 30 mg daily for 8 weeks for gastric ulcers or 6 weeks for duodenal ulcers. group 2 received the group 1 regimen plus amoxicilli ...19957594324
13c-ubt using an infrared spectrometer for detection of helicobacter pylori and for monitoring the effects of lansoprazole.the stable isotope [13c]-labeled urea breath test (13c-ubt) is very useful for detecting helicobacter pylori. conventionally, a mass spectrometer is used to measure the presence of 13co2 in breath. however, this technique is complex and expensive. therefore, we carried out the 13c-ubt using an easy-to-operate infrared spectrometer, and we studied its usefulness. the 95 subjects included 35 patients with gastric ulcers, 32 with duodenal ulcers, 13 with gastroduodenal ulcers, some patients with no ...19957594325
efficacy of lansoprazole and amoxicillin in eradicating helicobacter pylori: evaluation using 13c-ubt and monoclonal h. pylori antibody testing.combination therapy with lansoprazole (lpz) and amoxicillin (ampc) was administered to eradicate helicobacter pylori. changes in eradication rates were monitored and serum antibody titers, levels of pepsinogens i and ii (pi and pii), and gastrin were measured. the 40 subjects were divided into two groups: one group received lpz 30 mg alone, and the other received lpz 30 mg and ampc 1,500 mg concomitantly. ampc was administered for 2 weeks before completion of lpz treatment. maintenance therapy w ...19957594326
efficacy of lansoprazole in eradication of helicobacter pylori.fifty-eight helicobacter pylori-positive ulcer patients received omeprazole 20 mg (n = 15), or lansoprazole 30 mg (n = 23), lansoprazole 60 mg (n = 13), or e3810 20 mg (n = 7) q.d. another 63 h. pylori-positive ulcer patients received lansoprazole and clarithromycin for 2 weeks. patients received lansoprazole 30 mg and clarithromycin 400 mg (group 1, n = 22), lansoprazole 30 mg and clarithromycin 800 mg (group 2, n = 12), or lansoprazole 60 mg and clarithromycin 800 mg (group 3, n = 29). neither ...19957594327
eradication of helicobacter pylori with lansoprazole and clarithromycin in gastric ulcer patients.this study attempted to determine the efficacy of lansoprazole plus clarithromycin therapy in the eradication of helicobacter pylori in gastric ulcer patients. the influence of h. pylori eradication on healing and relapse of ulcers was also studied. thirty-nine patients received either lansoprazole 30 mg daily for 8 weeks (group 1) or clarithromycin 200 mg twice daily for 2 weeks and lansoprazole 30 mg daily for 8 weeks (group 2). before treatment, h. pylori status was evaluated by a rapid ureas ...19957594328
eradication of helicobacter pylori with lansoprazole, amoxicillin, and plaunotol in duodenal ulcer patients.helicobacter pylori eradication therapy combining amoxicillin (ampc), plaunotol (pl), and a proton pump inhibitor (ppi) was examined as an alternative to triple therapy, which has a high rate of side effects and low patient compliance. thirty-two h. pylori-positive patients (24 men, 8 women) with duodenal ulcers were examined. the diagnosis of h. pylori infection was made by the urease test on specimens biopsied from two sites in the stomach. simultaneously, the igg antibody against h. pylori wa ...19957594329
combination therapies with a proton pump inhibitor for helicobacter pylori-infected gastric ulcer patients.we investigated the eradication and recurrence rate of helicobacter pylori-infected gastric ulcer patients by combination therapies. eighty-six h. pylori-positive gastric ulcer patients were assigned randomly to one of seven groups: i, omeprazole 20 mg (n = 9); ii, lansoprazole (lpz) 30 mg (n = 16); iii, lpz 30 mg plus plaunotol 480 mg (n = 13); iv, lpz 30 mg plus ecabet sodium 2 g (n = 11); v, lpz 30 mg plus clarithromycin 600 mg (the first 2 weeks; n = 11); vi, lpz 30 mg plus plaunotol 480 mg ...19957594330
suppressive action of lansoprazole on gastric acidity and its clinical effect in patients with gastric ulcers: comparison with famotidine.we studied the action on acid secretion of lansoprazole compared with famotidine by 24-h intragastric ph monitoring, evaluated its clinical effects prospectively, and assessed the importance of acid inhibition in gastric ulcer patients. twenty symptomatic patients with active gastric ulcers diagnosed by endoscopy were assigned to a lansoprazole (lan) group (lansoprazole 30 mg q.d., n = 10) or a famotidine (fam) group (famotidine 20 mg b.i.d., n = 10). there were no differences between the groups ...19957594334
quality of peptic ulcer healing induced by lansoprazole and roxatidine.this study reports preliminary results of a controlled, multicenter trial on the quality of ulcer healing induced by lansoprazole (lpz) or roxatidine (r) in gastric ulcer (gu) or duodenal ulcer (du) patients. group a received lpz 30 mg q.d. and group b received r 75 mg b.i.d. all drugs were given for 8 weeks in gu and for 6 weeks in du. endoscopy and gastric biopsy were performed to detect helicobacter pylori before and on completion of treatment. the healing rates of groups a and b were 100 and ...19957594338
the effect of lansoprazole treatment on the healing and relapse of peptic ulcer and serum levels of igg anti-helicobacter pylori antibody.in the present study, the effects of short-term treatment with lansoprazole on healing and recurrence of peptic ulcer were investigated. complete healing (change to the s2 stage) after 3 or 4 weeks of treatment with lansoprazole was observed in 9.9% of gastric ulcers and 38.3% of duodenal ulcers. complete healing was observed after 3 or 4 weeks of treatment with lansoprazole in gastric ulcers and was significantly related to the serum titer of igg anti-helicobacter pylori antibodies. this was no ...19957594347
therapeutic effects of lansoprazole on peptic ulcers in elderly patients.we studied the effects of lansoprazole on ulcer healing and helicobacter pylori infection in elderly patients with peptic ulcers. in a group of 24 patients with gastric ulcers, the h. pylori infection rate was 100%. in the course of gastric ulcer healing with famotidine or lansoprazole alone, the h. pylori infection showed no signs of decline. the ulcer healing rates after 8 weeks were similar between the h2-receptor antagonist famotidine (73%), and the proton pump inhibitor lansoprazole (82%). ...19957594348
effect of lansoprazole on peptic ulcers.lansoprazole is the first proton pump inhibitor developed in japan. we studied the clinical efficacy of lansoprazole 30 mg q.d. on peptic ulcers and the subsequent relapse rates. the endoscopic healing rate of gastric ulcers (n = 86) after 8 weeks of treatment and duodenal ulcers (n = 52) after 6 weeks of treatment were 94.2 and 96.2%, respectively. the endoscopic s2-stage shift rates in gastric and duodenal ulcers were 45.5 and 65.4%, respectively. factors affecting healing rates of gastric ulc ...19957594350
lansoprazole reverses helicobacter pylori-inhibited gastric epithelial cell growth.helicobacter pylori is associated with retarded healing and recurrence of peptic ulcer. acid inhibitory agents, including proton pump inhibitors (ppis), accelerate healing of peptic ulceration. because epithelial cell proliferation is important for ulcer healing, we studied the effects of h. pylori and lansoprazole, a novel ppi, on gastric epithelial cell growth in vitro. cell viability was significantly decreased when they incubated with 10(8) cfu/ml h. pylori. nevertheless, all doses tested, f ...19957594352
lansoprazole inhibits oxygen-derived free radical production from neutrophils activated by helicobacter pylori.we studied the influence of lansoprazole on helicobacter pylori-elicited neutrophil activation, including the oxidative burst and infiltration of gastric mucosa, and confirmed whether radiolabeled lansoprazole is actually detected in gastric neutrophils. the oxidative burst of purified human neutrophils was measured by luminol-dependent chemiluminescence (chl). [3h]lansoprazole uptake sites in human gastric mucosa were observed by autoradiography. the magnitude of neutrophil infiltration of gast ...19957594353
peptic ulcer therapy with lansoprazole and helicobacter pylori eradication.this study investigated the relationship between the clearance of helicobacter pylori and the healing rate of ulcers after treatment with lansoprazole. lansoprazole 30 mg/day was administered to 124 gastric ulcer (gu) patients and 57 duodenal ulcer (du) patients. the healing rates were 89.6% in gu and 96.5% in du. the rate of shift to the s2 stage of healing was 33.1% in gu and 38.6% in du. the h. pylori-positive rate was 69.7% in gu and 74.5% in du. h. pylori clearance rates after lansoprazole ...19957594354
[epidemiology of helicobacter pylori infection in hungary (comparative sero-epidemiologic study)].in the last decade pathogenetical role of helicobacter pylori infection has been proved in development of gastroduodenal alterations. dna-rna hybridisation and protein profile studies proved that helicobacter pylori is an organism distinct from other bacteria. therefore serology became a useful method to study the epidemiology of helicobacter pylori infection in various populations. in hungary sera were collected from adults aged 20-60 in blood banks (military hospital, tolna county hospital) in ...19957596599
non-ulcer dyspepsia: does helicobacter pylori matter?non-ulcer dyspepsia is a heterogenous disorder characterised by chronic or recurrent abdominal or retrosternal discomfort lasting for more than four weeks for which no cause can be determined. helicobacter pylori has been implicated as a potential cause in a subset of patients but the association has not been proven and h pylori eradication in patients with non-ulcer dyspepsia has had variable results. large well-controlled studies are needed to clarify the relationship.19957596927
royal society of tropical medicine and hygiene meeting at manson house, london, 16 february 1995. aspects of helicobacter pylori infection in the developing and developed world. helicobacter pylori infection, nutrition and growth of west african infants.helicobacter pylori is probably the commonest bacterial infection of humankind. in adults, colonization of the stomach is associated with chronic gastritis and duodenal ulcer disease. however, children in the developing world acquire h. pylori soon after birth, and there is evidence that it plays a part, through suppression of the gastric acid barrier, in the pathogenesis of the syndrome of diarrhoea, malnutrition and growth failure. infants born of mothers who secrete milk with high levels of a ...19957570858
helicobacter pylori: i. ultrastructural sequences of adherence, attachment, and penetration into the gastric mucosa.new ultrastructural observations on the sequences of adherence, attachment, and penetration of helicobacter pylori (hp) into the gastric epithelium were described in 32 endoscopic biopsies selected randomly from 168 samples of patients with active chronic gastritis. the adherence of hp to the target cell was initiated by direct contact with the microvillar coat, or glycocalyx, leading to the loss of that coat. the next step was demolishing of the surface microvilli, which separate the organisms ...19957571091
[antibacterial treatment of gastric ulcers associated with helicobacter pylori without acid suppression]. 19957571762
cytologic brushing as a simple and rapid method in the diagnosis of helicobacter pylori infection.to assess broad antral cytologic brushing as an alternative approach for the diagnosis of helicobacter pylori gastric colonization as compared to histology.19957571970
gastric carcinoma: the helicobacter pylori trail.gastric carcinoma is the world's overall second most common cancer. besides obvious environmental factors, recent epidemiological studies and a better knowledge of helicobacter pylori biological properties revealed that the microorganism is involved in the first steps of gastric carcinogenesis as proposed by the correa model (from normal gastric tissue through superficial gastritis, multifocal atrophic gastritis, intestinal metaplasia and dysplasia to carcinoma). significant correlation between ...19957571979
are perforated gastroduodenal ulcers related to helicobacter pylori infection?the prevalence of helicobacter pylori gastritis in 36 patients with a perforated ulcer undergoing endoscopy prior to or at least 2 months after perforation was 56%, intermediate between that of age and sex matched healthy blood donors (36%) who had measurement of circulating antibodies to helicobacter pylori and of ulcer patients without perforation matched for age, sex and ulcer location (86%). in the 20 patients with helicobacter pylori gastritis, 8 had a history of peptic ulcer and 7 of 9 pat ...19957571981
lymphocytic gastritis. clinical and endoscopic presentation and long-term follow-up.lymphocytic gastritis is a histopathological entity corresponding with diffuse varioliform gastritis but also with other gastroscopic findings. eighteen patients were followed over a mean period of 25 months. the symptoms, the endoscopic and histopathological abnormalities remained unchanged in the majority of the cases. conventional peptic ulcer therapy failed to control symptoms or to normalize endoscopic alterations. helicobacter pylori did not seem to play a role in the pathophysiology. lymp ...19957571985
seroepidemiologic study of helicobacter pylori infection in children in taipei city.to study the epidemiology of helicobacter pylori (h. pylori) infection in children, the presence of the igg antibody against h. pylori was evaluated by enzyme-linked immunosorbent assay (elisa) method in unselected children in taipei city. serum samples were collected there from 428 apparently healthy children under 12 years of age. the overall prevalence of h. pylori infection was 8.4%. a low prevalence was found in the groups 1-3 years old (0.9%) and 3-6 years old (3.7%). the prevalence rate i ...19957572166
salivary-specific immunoglobulin g in the diagnosis of helicobacter pylori infection in dyspeptic patients.helicobacter pylori infection is arguably the most common chronic bacterial infection in humans. the high prevalence and the association with peptic ulceration and gastric cancer indicate that simple, noninvasive methods for diagnosis of the infection are needed. in this study, the accuracy of salivary diagnosis for h. pylori infection was assessed.19957572901
the effects of short-term lansoprazole therapy on helicobacter pylori infection and antral gastritis in duodenal ulcer patients.lansoprazole is a new potent proton pump inhibitor that exhibits activity against helicobacter pylori in vitro. this study endeavored to determine the effects of 4 wk of lansoprazole therapy upon h. pylori infection and antral gastritis in duodenal ulcer patients and to determine the relationship of the gastritis with helicobacter infection and with ulcer activity.19957572902
electron microscopic study of association between coccoid forms of helicobacter pylori and gastric epithelial cells.to investigate the relationship between helical and coccoid forms of helicobacter pylori and gastric epithelial cells.19957572903
low prevalence of helicobacter pylori in inflammatory bowel disease: association with sulfasalazine. 19957572928
do helicobacter pylori-positive duodenal ulcers have an increased risk of bleeding? 19957572929
biologic sex as a risk factor for helicobacter pylori infection in healthy young adults.diseases associated with helicobacter pylori infection, such as peptic ulcer disease and gastric cancer, afflict men more frequently than women. no study, however, has demonstrated any difference in sex-specific rates of h. pylori infection. in a healthy population undergoing multiphasic health evaluations in 1992-1993 as members of the kaiser permanente medical care program of northern california, adults aged 20-39 years were screened for antibodies to h. pylori infection using a serum enzyme-l ...19957572962
a cost analysis of alternative treatments for duodenal ulcer.to compare the costs of alternative strategies for the treatment of duodenal ulcer.19957574221
bacterial activity of a new antiulcer agent, ecabet sodium, against helicobacter pylori under acidic conditions.helicobacter pylori nctc 11637, which is nonviable at ph 3.0, became viable after addition of 10 mm urea owing to ammonia production by urease. in a buffer supplemented with urea, ecabet sodium decreased both the production of ammonia and the number of viable cells of h. pylori nctc 11637 and changed the bacteria from the bacilliform to the horseshoe or doughnut shape in a concentration-dependent manner. in particular, ecabet sodium (2 and 4 mg/ml) decreased the number of viable cells below the ...19957574519
oxidative metabolism in nonculturable helicobacter pylori and vibrio vulnificus cells studied by substrate-enhanced tetrazolium reduction and digital image processing.growing and nonculturable cells of helicobacter pylori and vibrio vulnificus were studied for the capacity to reduce tetrazolium salts in order to elucidate the possible physiological basis for the proposed "viable but nonculturable" (vnc) state. initial difficulties in obtaining consistent reduction of rho-iodonitrotetrazolium violet (int) by h. pylori led us to develop a method for studying the effect of adding exogenous substrates on these reactions. the established procedure provided a profi ...19957574647
'cure' of helicobacter pylori. clinically indicated and economically wise! 19957575045
cost-effectiveness of helicobacter pylori eradication for the long-term management of duodenal ulcer in canada.a 1994 national institutes of health consensus panel recommended that eradication of helicobacter pylori should be first-line therapy for persons with duodenal ulcer.19957575049
surgery for peptic ulcer in the helicobacter pylori era. 19957575113
[helicobacter pylori and non-ulcerous dyspepsia++]. 19957578810
[chronic gastritis and helicobacter pylori in patients with non-ulcerous dyspepsia. role and significance of age].patients with recurrent upper abdominal complaints and without peptic ulcer or definite evidence of organic disease have been labelled as suffering from nonulcer dyspepsia and included in the study. a total of 125 patients were studied and upper gastrointestinal endoscopy performed. histology, urease rapid test and elisa serology were done in order to detect helicobacter pylori infection. age groups were done. the most frequent endoscopic and histological finding was chronic gastritis in all age ...19957578811
[antral biopsy in the prevention of gastric disease].approximately 1% of the gastric neoplasies are nowadays associated with the infection of the gastric mucus by helicobacter pylori. in view of the fact that its prevalency is very high and that it does not exist any objective and universal estimator in its diagnosis but the digestive endoscopy and biopsy, it is proposed, in candidate patients for a digestive endoscopy, although the explorer observes an endoscopic normality, to carry out, systematically, and antral biopsy for its subsequent diagno ...19957578812
selective adherence of a sucralfate-tetracycline complex to gastric ulcers: implications for the treatment of helicobacter pylori.the adherence of a sucralfate-tetracycline complex to gastric ulcers and to nearby non-ulcer sites was determined in the rabbit antrum. persistent gastric ulcers were produced by a previously described method. the presence of the complex was assessed 1 and 4 h after dosing. drug adherence was determined by quantitation of aluminum in stomach wall biopsies. significantly more aluminum adhered to ulcer sites than to nearby non-ulcer sites. adherence of the complex did not significantly decrease fr ...19957579029
the urea breath test: a non-invasive clinical tool for detecting helicobacter pylori infection.the urea breath test exploits the urease enzyme of helicobacter pylori. the hydrolysis of labelled urea releases labelled carbon dioxide that is excreted in the breath. distribution of urea throughout the stomach prevents sampling errors and allows for semiquantitative assessment of the extent of helicobacter pylori infection. the urea breath test is very specific and sensitive and can be proposed as the method of choice for detecting helicobacter pylori infection in ulcer patients before and af ...19957579592
helicobacter pylori in a group of endoscopically examined patients in the county of medimurje.the presence of helicobacter pylori was investigated in 50 patients, mean age 54 years and age range 28-56 years. gastroduodenoscopy and biopsy of the antral and/or pyloric part of gastric mucous membrane were performed in all study patients. bioptic tissue was examined by culture and histologic staining, and tested by a rapid urease test. according to overall results, the urease test was most sensitive, i.e. positive in 23 (45%) patients, whereas histological staining was positive in 14 (29) pa ...19957580042
ability of bacteria associated with chronic inflammatory disease to stimulate e-selectin expression and promote neutrophil adhesion.porphyromonas gingivalis, pseudomonas aeruginosa, and helicobacter pylori have been shown to be associated with adult periodontal disease, chronic lung infections, and peptic ulcers, respectively. the ability of these bacteria to stimulate e-selectin expression and promote neutrophil adhesion, two components necessary for the recruitment of leukocytes in response to infection, was investigated. little or no stimulation of e-selectin expression was observed with either p. gingivalis or h. pylori ...19957534275
isolation and characterization of a family of porin proteins from helicobacter pylori.two-dimensional gel electrophoresis was used to identify heat-modifiable outer membrane proteins, which were candidates for porins, from helicobacter pylori membrane preparations. four such proteins with apparent molecular masses of 48, 49, 50, and 67 kda were isolated. the four proteins copurified together after selective detergent solubilizations followed by anion-exchange chromatography, and each protein was ultimately purified to homogeneity by gel purification. these proteins were then test ...19957534278
rabbit and ferret parietal cell inhibition by helicobacter species.we tested sonicates of helicobacter pylori, h. mustelae, and h. felis for inhibition of acid secretion in rabbit and ferret isolated gastric glands. three h. pylori strains, two of three h. mustelae strains, and two h. felis strains significantly inhibited acid secretion in rabbit cells by 95.2-93.3%, 55.9% and 96.4%, and 83.4-96%, respectively. all helicobacter strains examined inhibited acid secretion by ferret cells by 65.3-76.8%, 89.1-97.6%, and 85.8-92.8%. h. pylori inhibited acid secretion ...19957529671
migraine of gastrointestinal origin.a consecutive series of 31 children (median age 12 years) suffering from migraine with (n = 21) or without (n = 10) aura underwent endoscopic oesophageal, gastric and duodenal biopsy in order to determine whether the complaints were of gastro-intestinal origin. of these 31 children, 13 (41.9%) showed oesophagitis, 16 (51.6%) gastritis of corpus, 12 (38.7%) antral gastritis and 27 (87.1%) duodenitis. thus, 29 of the 31 children studied had an underlying inflammatory lesion explaining their compla ...19957641777
identification of two new genes in the pseudomonas aeruginosa amidase operon, encoding an atpase (amib) and a putative integral membrane protein (amis).the nucleotide sequence of the amidase operon of pseudomonas aeruginosa has been completed and two new genes identified amib and amis. the complete gene order for the operon is thus amiebcrs. the amib gene encodes a 42-kda protein containing an atp binding motif that shares extensive homology with the clp family of proteins and also to an open reading frame adjacent to the amidase gene from rhodococcus erythropolis. deletion of the amib gene has no apparent effect on inducible amidase expression ...19957642533
purification and characterization of ferritin from campylobacter jejuni.we purified an iron-containing protein from campylobacter jejuni using ultracentrifugation and ion-exchange chromatography. electron microscopy of this protein revealed circular particles with a diameter of 11.5 nm and a central core with a diameter of 5.5 nm. the protein was composed of a single peptide of 21 kda and did not serologically cross-react with horse spleen ferritin. the uv-visible spectrum of the protein showed no absorption peaks in the visible region, indicating that little or no ...19957646314
effects of flavonoids on parietal cell acid secretion, gastric mucosal prostaglandin production and helicobacter pylori growth.the effect of the flavonoids flavone, flavanone and quercetin on parietal cell acid production, h+/k(+)-atpase activity, gastric mucosal prostaglandin e2 biosynthesis and helicobacter pylori growth was studied. all flavonoids inhibited acid production in isolated parietal cells in response to histamine and dibutyryl-camp stimulation (ic50 values between 26 and 139 mumol/l) and inhibited h+/k(+)-atpase activity. inhibition of h+/k(+)-atpase activity was dependent on the atp concentration. fluores ...19957646573
[study on therapeutic mechanism of xi lei powder for peptic ulcer].we studied 128 patients with active peptic ulcer diagnosed by gastro-endoscopy four weeks after treatment with xi lei powder, pge2 levels in both serum and gastro-duodenal mucosa were significantly higher than that before the treatment, the difference was significant (p < 0.01). the rate of negative conversion of helicobacter pylori (hp) showed in 63.3% of cases. the distributed density of hp significantly reduced, the difference was significant (p < 0.01). these results indicated that xi lei po ...19957647543
serum antibody against helicobacter pylori assayed by a new capture elisa.we developed a highly specific detection technique for serum antibody, using a monoclonal antibody to a specific antigen of helicobacter pylori. a monoclonal antibody preparation that reacted with the 54-kda molecule of h. pylori antigens was obtained. using this preparation, an antigen-capture enzyme-linked immunosorbent assay (elisa) was established by fixation of the monoclonal antibody, followed by reaction with sonicated whole cell antigens. the serum antibody titers of patients with gastri ...19957647894
lipid composition and fatty acid analysis of helicobacter pylori.lipids extracted from helicobacter pylori were separated into lipid classes by thin-layer chromatography. simple h. pylori lipids consisted of cholesterol esters, triglycerides, free fatty acids, cholesterol, diacylglycerols, and monoacylglycerols. fatty acids were released from each lipid class by acid methanolysis, and analyzed by gas liquid chromatography and mass spectrometry. unique methoxy fatty acids, including 11-methoxy heptadecanoic and 11-methoxy nonadecanoic acids, were the major com ...19957647897
omeprazole-amoxycillin therapy for eradication of helicobacter pylori in duodenal ulcer bleeding: preliminary results of a pilot study.thirty-five patients with duodenal ulcer bleeding and helicobacter pylori-colonization were assigned to receive 2 x 20 mg omeprazole and 3 x 750 mg amoxycillin daily for 2 weeks. eradication was defined as no evidence of h. pylori infection by urease test and by histology 4 weeks after completion of therapy. two patients were lost to follow up. all ulcers healed completely (100% ulcer healing rate). twenty-nine out of the 33 patients were h. pylori-negative (87.9% eradication rate). three patien ...19957647898
helicobacter pylori infection in perforated peptic ulcer disease. 19957648182
inhibition of helicobacter pylori urease by phenyl phosphorodiamidates: mechanism of action.helicobacter pylori urease is a nickel-containing enzyme that hydrolyzes urea to bicarbonate and ammonia. andrews et al. (j. am. chem. soc. 1986, 108, 7124) have shown that amides and esters of phosphoric acid are slow, tight-binding inhibitors of urease isolated from jack bean. we show that 4-substituted phenyl phosphorodiamidates (4-r-phop(=o)(nh2)2) are slow-binding inhibitors of h. pylori urease with no evidence of kinetic saturation. their second-order rates of inhibition ki are strongly co ...19957648208
treatment of helicobacter pylori infections.the available literature on the relationship between several diseases and helicobacter pylori (h. pylori) is reviewed. duodenal ulcer, gastric ulcer, complicated peptic ulcer, abdominal symptoms and gastroduodenal mucosal damage during the use of non-steroid anti-inflammatory drugs (nsaids), non-ulcer dyspepsia (nud) and gastric malignancy are discussed. the case for and against eradication is critically discussed. eradication of h. pylori should be pursued in all patients with peptic ulcer dise ...19957648229
the relationship between the presence of helicobacter pylori, clostridium perfringens type a, campylobacter spp, or fungi and fatal abomasal ulcers in unweaned beef calves.a case-control study involving 30 unweaned beef calves was conducted to determine whether specific species of bacteria or fungi were associated with fatal abomasal ulcer formation. special microbiological and histological techniques were used to detect clostridium perfringens type a, helicobacter pylori, or campylobacter spp. it has been speculated that these bacteria are potential ulcerogenic agents of unweaned beef calves. calves were recruited for the study at necropsy, with those dying of ei ...19957648542
validation of a modified kirby-bauer disk diffusion method for metronidazole susceptibility testing of helicobacter pylori.triple antimicrobial therapy that includes metronidazole has been recommended as a first-line therapy for helicobacter pylori because it has the highest eradication rates. however, resistance in h. pylori to metronidazole has been reported worldwide and its presence may reduce the efficacy of triple therapy. various methods for testing h. pylori against metronidazole have been used including agar dilution, disk diffusion and the etest but there has been little standardization of methods. one hun ...19957648834
helicobacter pylori status, endoscopic findings, and serology in hiv-1-positive patients.we have carried out a large prospective study of the frequency of h. pylori infection and hiv-1 status in a community of ex-drug abusers including subjects with (n = 210) and without (n = 259) upper gastrointestinal symptoms, endoscopy and serology. control groups were patients with upper gastrointestinal symptoms not at high risk of hiv-1 infection (n = 219) and asymptomatic blood donors (n = 322). h. pylori was present in 52% of symptomatic community residents having endoscopy and 55% of the c ...19957648959
effect of eradication of helicobacter pylori infection on gastric epithelial cell proliferation.helicobacter pylori infection has been linked with gastric carcinoma. epithelial cell proliferation is an indicator of cancer risk. the aim of this study was to assess gastric epithelial cell proliferation before and after eradication therapy and to assess the efficacy of treatment of h. pylori infection using lanzoprazole and clarithromycin. twenty-three patients with h. pylori-associated gastritis were treated with lanzoprazole 30 mg daily for four weeks and clarithromycin 500 mg three times a ...19957648960
transport and storage of helicobacter pylori from gastric mucosal biopsies and clinical isolates.various transport and storage conditions for the recovery of helicobacter pylori from gastric biopsies were evaluated. gastric mucosal biopsies from 16 helicobacter pylori-infected patients were stored in cysteine-albimi medium containing 20% glycerol in a refrigerator (4 degrees c) for 1 and 2 weeks and in a -20 degrees c laboratory freezer for 4 and 12 weeks. two clinical isolates were stored in saline, stuart's transport media, cysteine-albimi broth with 20% glycerol, brucella broth with 20% ...19957649201
effect of an acidic environment on the susceptibility of helicobacter pylori to trospectomycin and other antimicrobial agents.the susceptibility of 30 clinical isolates of helicobacter pylori to trospectomycin, ampicillin, metronidazole, clarithromycin, azithromycin and clindamycin under varying ph conditions was evaluated. an acidic environment was shown to affect unfavourably the activity of all the antimicrobial agents tested. this ph effect was most marked for the two macrolides and for clindamycin.19957649202
seroepizootiology of helicobacter pylori gastric infection in nonhuman primates housed in social environments.we determined the seroepizootiology of helicobacter pylori infection in rhesus monkeys. plasma was obtained from 196 animals (age range, 1 to 22 years) that were housed in social environments, either in indoor gang cages, in outdoor corrals, or in free-ranging forested conditions. plasma immunoglobulin g levels were determined with a specific enzyme-linked immunosorbent assay, and the cutoff immunoglobulin g value for h. pylori seropositivity was determined from a study of 25 monkeys whose infec ...19957650173
serologic detection of infection with caga+ helicobacter pylori strains.approximately 60% of helicobacter pylori isolates possess the caga gene and express its 120- to 140-kda product (caga). in this study, the caga gene was detected in h. pylori isolates from 26 (81.3%) of 32 patients with duodenal ulcers (du), 17 (68.0%) of 25 patients with gastric ulcers, and 23 (59.0%) of 39 patients with nonulcer dyspepsia (nud). by western blotting (immunoblotting) with antiserum to caga, in vitro caga expression was demonstrated for 95.5% of caga+ strains compared with 0% of ...19957650174
prevalence of helicobacter pylori in family practice patients with refractory dyspepsia: a comparison of tests available in the office.helicobacter pylori is emerging as an important cause of peptic disease; however, few studies have been performed in primary care settings. this study examines the prevalence of h pylori in a population of primary care patients with refractory dyspepsia and evaluates the usefulness of currently available h pylori tests.19957650503
adaptation of the [13c]urea breath test as a noninvasive method for detection of helicobacter pylori infection in squirrel monkeys (saimiri spp.).the [13c]urea breath test was adapted for use in squirrel monkeys (saimiri spp.) for identification of experimentally induced infection with helicobacter pylori, the bacterium causing gastric ulcer in humans. a canine anesthesia inhalation mask was modified with a volume-reducing insert allowing sufficient breath collection from these small primates within 30 sec. fourteen milligrams of [13c urea per kilogram of body weight was adequate for clear distinction between experimentally infected and n ...19957650891
[the complement fixation reaction: a traditional, updated method for the detection of antibodies in the diagnosis of infections].complement-fixation (cf) is still an important basic serologic test for the diagnosis of infectious diseases. in several areas of microbiology (viral, bacterial, parasitic and fungal) it has served as a reference standard against which other methods have been compared. its partial displacement by other techniques, as advocated in some recent literature, is often unfounded and uncritical; displacement is mostly due not to problems inherent in the method, but rather to the lack of reagents of sati ...19957651069
helicobacter pylori nickel-transport gene nixa: synthesis of catalytically active urease in escherichia coli independent of growth conditions.urease is a virulence determinant, a taxonomic and diagnostic marker, and immunogen for helicobacter pylori, an aetiologic agent of gastritis and peptic ulceration. this enzyme requires ni2+ ions in the active site for successful hydrolysis of urea. when expressed in escherichia coli, recombinant urease is only weakly active unless urease structural subunits are overexpressed, exogenous nicl2 is added, and the host strain is grown in medium that does not chelate free ni2+. as wild-type h. pylori ...19957651142
[helicobacter pylori-associated gastroduodenal pathology]. 19957653123
peptic ulcer--a new look.this review covers major advances in peptic ulcer disease over the last 25 years. flexible endoscopy enables accurate diagnosis of peptic ulcer to be made and its introduction made possible the large number of controlled clinical trials on the use of various agents in peptic ulcer treatment. the histamine h-2 receptor antagonists, which reduce gastric acid output, were the first major group of potent ulcer healing drugs introduced. subsequently, other ulcer healing agents with different modes of ...19957653963
treatment of helicobacter pylori infection with a combination of itraconazole and omeprazole.to determine the in vivo anti-microbial activity of a high-dose itraconazole and omeprazole regimen against helicobacter pylori.19957654896
modulins: a new class of cytokine-inducing, pro-inflammatory bacterial virulence factor.despite the fact that the inflammatory and immune responses have evolved to combat microorganisms, the present generation of inflammation researchers has evinced relatively little interest, with the exception of septic shock, in microbially-induced inflammation. this in spite of the fact that the gram-negative cell wall constituent, lipopolysaccharide, has been widely used as a tool in inflammation research. the reason for such lack of interest has been due to the therapeutic efficacy of antibio ...19957655992
two-year follow-up of duodenal ulcer patients treated with omeprazole and amoxicillin.the present study evaluated the time in remission during a 2-year follow-up after eradication of helicobacter pylori (hp) in patients with an hp-associated duodenal ulcer (du). hp was eradicated by combined treatment with high-dose omeprazole (2 x 40 mg) and amoxicillin (2 x 1,000 mg; n = 27) administered for 10 days (ome + amx); alternatively, patients were treated with omeprazole monotherapy (ome) using the same dosage (n = 25). during the 2-year follow-up period endoscopy including histologic ...19957657042
helicobacter pylori infection and abnormalities of acid secretion in patients with duodenal ulcer disease.the mechanism by which helicobacter pylori predisposes to duodenal ulcers (dus) remains unclear. the aim of this study was to investigate the effect of the infection on acid secretion.19957657096
comparison of helicobacter mustelae and helicobacter pylori adhesion to eukaryotic cells in vitro.bacterial adhesion to mucosal surfaces is an important pathogenic mechanism for helicobacter-induced gastritis. the aims of this study were to compare binding of selected helicobacter mustelae and helicobacter pylori strains to lipids extracted from hep-2, chinese hamster ovary, human embryonic lung cells, and ferret gastrointestinal tissues as well as to intact tissue culture cells and to analyze the fatty acids of the receptor.19957657097
prevalence of helicobacter pylori infection in subtypes of gastric cancer.although helicobacter pylori has already been declared a human carcinogen, the exact nature of the association with gastric cancer remains to be explored. the aim of this study was to determine if the association is confined to specific types of gastric cancer.19957657118
resolution of helicobacter pylori-associated gastric lymphoproliferative disease in a child.a possible causative association between helicobacter pylori infection and gastric lymphoproliferative disorders has recently been recognized. the case of a 14-year-old girl who was diagnosed with h. pylori gastritis and associated gastric lymphoproliferative disease of the low-grade mucosa-associated lymphoid tissue type is reported. the patient was treated only for the h. pylori infection (amoxicillin, bismuth, and metronidazole) without any adjuvant chemotherapy or surgery for her lymphoproli ...19957657127
relationship of serum gastrin and helicobacter pylori in the gastric antral and body mucosa.to evaluate the relationship between serum gastrin and helicobacter pylori status in the antrum and body of gastric mucosa.19957657374
[helicobacter pylori and etiology of peptic ulcers]. 19957658114
[clinical significance of clearing helicobacter pylori in the treatment of peptic ulcer]. 19957658124
hyperammonaemia and helicobacter pylori. 19957658863
helicobacter pylori infection in dentists--a case-control study.to test the null hypothesis that frequent and multiple salivary exposure is not a risk factor for developing h. pylori infection, serum anti-h. pylori igg from 179 dentists and dental students and 179 age-, sex- and socioeconomic-matched controls were assayed using an elisa. seroprevalence in dentists was 16% (11/70); clinical dental students 6% (3/47); and pre-clinical dental students 10% (6/62). there were no differences in h. pylori seropositivity between cases and controls. there was an incr ...19957660079
the gastric microenvironment determines helicobacter pylori colonization. 19957661153
increase of helicobacter pylori-associated corpus gastritis during acid suppressive therapy: implications for long-term safety.helicobacter pylori causes chronic active gastritis with predominant localization in the gastric antrum. this predisposes to development of mucosal atrophy, intestinal metaplasia, and eventually, gastric cancer. the effects of acid suppression on h. pylori infection and associated gastritis are unclear. however rapid development of atrophic gastritis has been consistently observed in a number of studies during low acid output. we therefore studied the histological features of antrum and corpus o ...19957661157
limited efficacy of omeprazole-based dual and triple therapy for helicobacter pylori: a randomized trial employing "optimal" dosing.to evaluate the efficacy and side effects of dual omeprazole/amoxicillin therapy for helicobacter pylori given in "optimal" fashion (omeprazole twice a 3 g of amoxicillin daily, drugs started concurrently, 2 wk of therapy) and to assess the utility of adding a second antibiotic, tetracyline.19957661158
treatment of helicobacter pylori infection with omeprazole-amoxicillin combination therapy versus ranitidine/sodium bicarbonate-amoxicillin.simpler, effective therapies to treat helicobacter pylori infection are greatly needed. omeprazole co-therapy apparently enhances effectiveness of some antimicrobials. our objective in this study was to determine whether the apparent additional benefit provided by omeprazole to amoxicillin therapy could be equaled by a high dose of ranitidine plus sodium bicarbonate.19957661159
variability with omeprazole-amoxicillin combinations for treatment of helicobacter pylori infection.although omeprazole co-therapy enhances the effectiveness of some antimicrobials for the treatment of helicobacter pylori infection, results have not been uniform. a meta-analysis suggested that 20 mg of omeprazole b.i.d. and 2 g or more of amoxicillin would yield a > 80% success rate (gastroenterology 1994; 106: 142a). our objective in this study was to test that hypothesis.19957661160
effect of triple therapy or amoxycillin plus omeprazole or amoxycillin plus tinidazole plus omeprazole on duodenal ulcer healing, eradication of helicobacter pylori, and prevention of ulcer relapse over a 1-year follow-up period: a prospective, randomized, controlled study.triple therapy and amoxycillin plus omeprazole are the two most widely recommended regimens for the eradication of helicobacter pylori. however, no controlled studies with a large number of cases are available for the reliable comparison of these two regimens. the aim of this controlled, randomized, prospective study was to compare the effect of these two regimens and a further regimen for metronidazole-resistant patients on duodenal ulcer healing, h. pylori eradication, and prevention of ulcer ...19957661161
triple therapy with sucralfate, tetracycline, and metronidazole for helicobacter pylori-associated duodenal ulcers.triple therapy with bismuth, metronidazole, and tetracycline or amoxicillin is effective for the treatment of helicobacter pylori, but side effects are common. sucralfate inhibits h. pylori hemagglutinin, protease, and lipase and thus might affect colonization of the bacterium in the stomach.19957661162
gastric syphilis: endoscopic and histological features mimicking lymphoma.the united states is currently experiencing a syphilis epidemic. we report three cases of gastric syphilis seen during a 1-yr period. these cases were endoscopically and microscopically confused with lymphoma. recent evidence has suggested that helicobacter pylori has a causative role in the development of gastric carcinoma, lymphocytic gastritis, and lymphoma, as well as peptic ulcer disease and chronic gastritis. during the same period of heightened awareness for the role of h. pylori-associat ...19957661178
eradication of helicobacter pylori by a combination of amoxicillin and famotidine. 19957661196
is short-term triple therapy with lansoprazole, clarithromycin, and metronidazole a definitive answer for helicobacter pylori eradication? 19957661197
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