Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| the role of virus-specific immunoglobulin e in airway hyperresponsiveness. | respiratory syncytial virus (rsv) is the most common cause of bronchiolitis during infancy and is associated with subsequent wheezing and asthma, but the nature of this association is not fully understood. we investigated the role of rsv-specific ige antibodies in the pathophysiology of virus-induced airway dysfunction in a mouse model. lung infection with rsv resulted in significant increases in mrna expression for ige and both of its high- and low-affinity receptors. in serum, virus-specific i ... | 2004 | 15306536 |
| quantitative effects of palivizumab and donor-derived t cells on chronic respiratory syncytial virus infection, lung disease, and fusion glycoprotein amino acid sequences in a patient before and after bone marrow transplantation. | a patient with respiratory syncytial virus (rsv) infection and severe combined immunodeficiency was studied during a 3-month period of bone marrow transplantation and palivizumab infusion. no rsv isolates with palivizumab escape mutations were identified. donor lymphocytes, including cd8 cells, appeared to markedly reduce the rsv load but increased the pulmonary symptoms. immunosuppressive therapy ameliorated lung disease but allowed the rsv load to rebound. | 2004 | 15307047 |
| respiratory virus infections in stockholm during seven seasons: a retrospective study of laboratory diagnosis. | a retrospective analysis of the virological findings in all respiratory samples (7303) analysed at the laboratory of karolinska hospital between 1993 and 2000 was performed. the findings were studied according to age and seasonal variation, and the methods were evaluated. most samples were from children. rsv was the dominant agent, found in 34% of all samples from children 0-1 y of age. influenza a was found in 13% of samples from the age group 2-5 y. influenza a dominated among adults and the e ... | 2004 | 15307569 |
| incidence of respiratory syncytial virus infection in infants and young children referred to the emergency departments for lower respiratory tract diseases in italy. | respiratory syncytial virus (rsv) is the leading cause of emergency visits and hospitalization for acute lower respiratory tract infections (lrti) in infants and young children worldwide. to collect specific epidemiological data on the incidence of rsv infection among infants referred to emergency departments (ed) for lrti in a mediterranean country, an italian multicenter epidemiological surveillance program was established. | 2004 | 15315084 |
| prolonged production of tnf-alpha exacerbates illness during respiratory syncytial virus infection. | cd8(+) ctl are the main effector cells responsible for resolving viral infections. however, the ctl response to respiratory syncytial virus (rsv) infection in mice facilitates viral clearance at the expense of significant immunopathology. previous reports have shown a strong correlation between the mechanism of ctl activity and the severity of rsv-induced illness. furthermore, experiments in perforin knockout mice revealed that antiviral cytokine production temporally correlated with rsv-induced ... | 2004 | 15322205 |
| human metapneumovirus and severity of respiratory syncytial virus disease. | we screened 23 children with severe respiratory syncytial virus (rsv) disease and 23 children with mild rsv disease for human metapneumovirus (hmpv). although hmpv was circulating in connecticut, none of the 46 rsv-infected patients tested positive for hmpv. in our study population, hmpv did not contribute to the severity of rsv disease. | 2004 | 15324559 |
| serological cross-reactivity of members of the metapneumovirus genus. | respiratory tract infections are a leading cause of morbidity and mortality worldwide. human metapneumovirus (hmpv) is a recently discovered respiratory pathogen of the paramyxovirus family in the metapneumovirus genus. hmpv was first isolated from young children in the netherlands with respiratory illness similar to human respiratory syncytial virus (rsv) infection. epidemiological data indicates that hmpv co-circulates with rsv in the community. few immunological tools are available to study t ... | 2004 | 15325082 |
| mucosal immune responses to infections in infants with acute life threatening events classified as 'near-miss' sudden infant death syndrome. | this study examined the hypothesis that dysregulation of mucosal immune responses to respiratory infections is a critical event, which could be causal in respiratory arrest of some previously healthy infants. to examine this hypothesis, a prospective study was undertaken of infants presenting to the emergency department of a major teaching hospital with acute life threatening events (alte) of unknown cause and classified as "near-miss" sids. salivary immunoglobulin concentrations were measured o ... | 2004 | 15325403 |
| an outbreak of respiratory infection due to respiratory syncytial virus subgroup b in ankara, turkey. | during the outbreak, from 16 january 2002 to 3 march 2002, nasopharyngeal secretions obtained from 35 pediatric patients under 2 years of age and suffering from acute respiratory disease were tested by vidas respiratory syncytial virus (rsv) assay (an automated enzyme-linked fluorescent immunoassay) and reverse transcription- polymerase chain reaction (rt-pcr). rsv antigen was detected in 16 specimens by vidas rsv assay, and 15 of these were confirmed by the rt-pcr. a total of 18 samples were fo ... | 2004 | 15329452 |
| progress in defining the role of rsv in allergy and asthma: from clinical observations to animal models. | respiratory syncytial virus (rsv), an rna virus in the family paramyxoviridae, causes respiratory disease in humans. a closely related bovine rsv is responsible for a remarkably similar disease syndrome in young cattle. severe rsv disease is characterized by bronchiolitis. the impact of rsv on human health is demonstrated annually when infants are admitted to the hospital in large numbers. nearly every child will have been infected with rsv by the age of 3 years. while the disease is most severe ... | 2004 | 15330446 |
| molecular epidemiology of respiratory syncytial virus in kilifi district, kenya. | respiratory syncytial virus (rsv) causes significant burden of disease during infancy and childhood. this study examined the genetic relatedness of rsv positive samples from child inpatients and outpatients and a birth cohort from a rural coastal district of kenya and also the distribution of strains between these three groups. clinical samples were collected over a 4-year period in kilifi district, kenya from community and hospital surveillance. three hundred ninety seven of 1,044 nasal specime ... | 2004 | 15332285 |
| evaluation of sulfated fungal beta-glucans from the sclerotium of pleurotus tuber-regium as a potential water-soluble anti-viral agent. | six water-insoluble fractions of fungal beta-glucans extracted by hot alkali (tm8-1 to tm8-6) from the sclerotia of pleurotus tuber-regium (ptr) having different molecular weights (m(w)) were sulfated to give their corresponding water-soluble derivatives (s-tm8-1 to s-tm8-6) with the degree of sulfation (ds) ranging from 1.14 to 1.74. the in vitro anti-viral activities of the native beta-glucans (tm8s) and their sulfated derivatives (s-tm8s) were evaluated by the cytopathic effect assay (cpe) an ... | 2004 | 15337458 |
| rate of palivizumab administration in accordance with current recommendations among hospitalized children. | the american academy of pediatrics recommends palivizumab prophylaxis for children born premature or with chronic lung disease to reduce the severity of respiratory syncytial virus (rsv) infection. the purpose of the current study is to examine palivizumab administration among children hospitalized with rsv infection. | 2004 | 15337916 |
| does respiratory syncytial virus subtype influences the severity of acute bronchiolitis in hospitalized infants? | respiratory syncytial virus (rsv) subtypes a and b are present either simultaneously or alternate during yearly epidemics. it is still not clear whether clinical severity of acute bronchiolitis differs between the two subtypes. reverse transcription polymerase chain reaction was used to subtype rsv in previously healthy infants hospitalized with rsv bronchiolitis during a winter epidemic. a severity index based on heart rate, respiratory rate, wheezing, difficulty in feeding and oxygen saturatio ... | 2004 | 15338801 |
| effects of low sulfur fuel and a catalyzed particle trap on the composition and toxicity of diesel emissions. | in this study we compared a "baseline" condition of uncontrolled diesel engine exhaust (dee) emissions generated with current (circa 2003) certification fuel to an emissions-reduction (er) case with low sulfur fuel and a catalyzed particle trap. lung toxicity assessments (resistance to respiratory viral infection, lung inflammation, and oxidative stress) were performed on mice (c57bl/6) exposed by inhalation (6 hr/day for 7 days). the engine was operated identically (same engine load) in both ca ... | 2004 | 15345344 |
| use of palivizumab to control an outbreak of syncytial respiratory virus in a neonatal intensive care unit. | to evaluate the safety and effectiveness of a humanized respiratory syncytial virus (rsv) monoclonal antibody (palivizumab) to control an outbreak of rsv in a neonatal intensive care unit (nicu), we retrospectively analysed two rsv outbreaks. between 11 november 1998 and 18 march 1999, two separate rsv outbreaks occurred in a large (26 beds) nicu. all procedures for preventing nosocomial spread of rsv (including the use of palivizumab in the second outbreak) were retrospectively analysed. the cu ... | 2004 | 15350712 |
| analysis of the interaction between respiratory syncytial virus and lipid-rafts in hep2 cells during infection. | the assembly of respiratory syncytial virus (rsv) in lipid-rafts was examined in hep2 cells. confocal and electron microscopy showed that during rsv assembly, the cellular distribution of the complement regulatory proteins, decay accelerating factor (cd55) and cd59, changes and high levels of these cellular proteins are incorporated into mature virus filaments. the detergent-solubility properties of cd55, cd59, and the rsv fusion (f) protein were found to be consistent with each protein being lo ... | 2004 | 15351205 |
| molecular epidemiology of respiratory syncytial virus (rsv) of group a in stockholm, sweden, between 1965 and 2003. | the epidemiology of respiratory syncytial virus (rsv) group a was followed by nucleotide sequencing of the variable parts of the glycoprotein (g) gene. the amino acid sequences of an aminoterminal (a-terminal, amino acids 90-132) and carboxyterminal (c-terminal, amino acids 262-298) portion of the g protein in 47 virus strains, collected in stockholm, between 1965 and 2004, were determined. in phylogenetic analysis jointly with previously described genotypes (ga1 to ga7 and saa1), 33 virus strai ... | 2004 | 15351487 |
| the conserved amino-terminal region (amino acids 1-20) of the hepatitis b virus x protein shows a transrepression function. | the x protein of hepatitis b virus or hbx is a multifunctional regulatory protein that carries the fame of a promiscuous transactivator. although, the n-terminal 'a' region of hbx (amino acids 1-20) is the most conserved region among mammalian hepadnavirus genomes, it has been found to be dispensable for transactivation function [proc. natl. acad. sci. u.s.a. 93, 1996, 5647]. to elucidate its biological role, dna sequence corresponding to the a region of x gene was amplified by polymerase chain ... | 2004 | 15351489 |
| functional characterization of a recombinant adeno-associated virus 5-pseudotyped cystic fibrosis transmembrane conductance regulator vector. | despite extensive experience with recombinant adeno-associated virus (raav) 2 vectors in the lung, gene expression has been low in the context of cystic fibrosis (cf) gene therapy, where the large size of the cystic fibrosis transmembrane conductance regulator (cftr) coding sequence has prompted the use of compact endogenous promoter elements. we evaluated the possibility that gene expression from recombinant adeno-associated virus (raav) could be improved by using alternate aav capsid serotypes ... | 2004 | 15353038 |
| polyadenylation-dependent screening assay for respiratory syncytial virus rna transcriptase activity and identification of an inhibitor. | rna-dependent rna polymerase from respiratory syncytial virus (rsv) is a multi-subunit ribonucleoprotein (rnp) complex that, in addition to synthesizing the full 15 222 nt viral genomic rna, is able to synthesize all 10 viral mrnas. we have prepared crude rnp from rsv-infected hep-2 cells, based on a method previously used for newcastle disease virus, and established a novel polyadenylation-dependent capture [poly(a) capture] assay to screen for potential inhibitors of rsv transcriptase activity ... | 2004 | 15356293 |
| association study suggests opposite effects of polymorphisms within il8 on bronchial asthma and respiratory syncytial virus bronchiolitis. | il-8 is a strong inductor of inflammation. accordingly, it plays a pivotal role in acute inflammatory responses during respiratory syncytial virus (rsv) infections and in chronic inflammatory diseases such as bronchial asthma and juvenile idiopathic arthritis. recently, 2 studies have found association of the polymorphism -251a of il8 with rsv bronchiolitis. furthermore, epidemiologic studies have demonstrated an increased risk for the development of asthma after rsv bronchiolitis, and a common ... | 2004 | 15356575 |
| pretransplantation respiratory syncytial virus infection: impact of a strategy to delay transplantation. | delay of hematopoietic stem cell transplantation (hsct) has been suggested if upper respiratory tract infection (urti) due to respiratory syncytial virus (rsv) occurs in transplantation candidates, but the efficacy of this strategy in preventing posttransplantation rsv infection is unknown. | 2004 | 15356782 |
| respiratory syncytial virus-induced immunoprotection and immunopathology. | respiratory syncytial virus (rsv), a member of the paramyxoviridae family, is a major clinical problem causing yearly epidemics of severe lower airway disease in both infants and the elderly. attempts at vaccination have been frustrated by both the poor immunogenicity of this virus, and the severe immunopathology observed in early vaccine trials. primary infection generally occurs in infancy, with approximately 5% of infected infants requiring hospitalization. equally problematic is the apparent ... | 2004 | 15357903 |
| the pediatric investigators collaborative network on infections in canada study of predictors of hospitalization for respiratory syncytial virus infection for infants born at 33 through 35 completed weeks of gestation. | infants born at 33 through 35 completed weeks of gestation (33-35ga) are at risk for severe respiratory syncytial virus (rsv) infection, and palivizumab prophylaxis lowers hospitalizations for rsv infection by as much as 80%. the 33-35ga cohort comprises 3-5% of annual births; thus expert panels recommend limiting prophylaxis to situations in which frequency or health care impact of rsv infection is high. this study sought to identify independent risk factors for hospitalization for rsv infectio ... | 2004 | 15361717 |
| case-control study of the risk factors linked to respiratory syncytial virus infection requiring hospitalization in premature infants born at a gestational age of 33-35 weeks in spain. | the aim of this study was to identify those risk factors most likely to lead to the development of rsv-related respiratory infection and subsequent hospital admission among premature infants born at 33-35 wga (flip study) | 2004 | 15361718 |
| evaluation of quantitative and type-specific real-time rt-pcr assays for detection of respiratory syncytial virus in respiratory specimens from children. | respiratory syncytial virus (rsv) is a major cause of lower respiratory tract morbidity in young children and immunosuppressed patients. | 2004 | 15364268 |
| comparison of two new rapid antigen detection assays for respiratory syncytial virus with another assay and shell vial culture. | respiratory syncytial virus (rsv) is the major viral pathogen causing lower respiratory tract infection in young children. early detection allows cohorting of infected inpatients to prevent nosocomial transmission and consideration of treatment. to achieve rapid reporting, antigen detection has been widely used. since late 2002, the fda approved two new rsv antigen detection tests, the now rsv test (binax) and the directigen ez rsv (becton dickinson), both of which promised reduced hands-on proc ... | 2004 | 15364269 |
| treating acute bronchiolitis associated with rsv. | treatment for infants with bronchiolitis caused by respiratory syncytial virus (rsv) includes supplemental oxygen, nasal suctioning, fluids to prevent dehydration, and other supportive therapies. high-risk children who should be hospitalized include those younger than three months and those with a preterm birth, cardiopulmonary disease, immunodeficiency, respiratory distress, or inadequate oxygenation. inhaled beta2-agonist bronchodilators, the anticholinergic agent ipratropium bromide, and nebu ... | 2004 | 14765771 |
| erk-1/2 activity is required for efficient rsv infection. | respiratory syncytial virus (rsv) infection up-regulates the expression of genes encoding proinflammatory mediators in bronchial epithelial cells. however, the specific signaling events immediately following rsv exposure are poorly understood. herein, we report that rsv attachment to a549 cells activates both erk-1 and erk-2 pathways within 5 min. inhibition of erk pathways significantly decreases rsv infection of these cells compared to controls. these results demonstrate that the activation of ... | 2004 | 14960303 |
| ikappab kinase is a critical regulator of chemokine expression and lung inflammation in respiratory syncytial virus infection. | respiratory syncytial virus (rsv) is the major etiologic agent of severe epidemic lower respiratory tract infections in infancy. airway mucosal inflammation plays a critical role in the pathogenesis of rsv disease in both natural and experimental infections. rsv is among the most potent biological stimuli that induce the expression of inflammatory genes, including those encoding chemokines, but the mechanism(s) that controls virus-mediated airway inflammation in vivo has not been fully elucidate ... | 2004 | 14963119 |
| the effect of respiratory synctial virus on chemokine release by differentiated airway epithelium. | respiratory synctial virus (rsv) infection of undifferentiated airway epithelial cells has been shown to induce the production of chemokines. the purpose of this study was to investigate the vectorial release of interleukin (il-8) and released on activation, normal t-cell expressed and secreted (rantes) by polarized, well-differentiated respiratory epithelial cells after rsv infection. human bronchial epithelial cultures were differentiated under air-liquid interface conditions and infected with ... | 2004 | 14967603 |
| gene transfer by retroviral vectors: an overview. | viruses have evolved to deliver their genetic cargo to cells and, due to the pathogenicity of some viruses, this process has been the subject of a great deal of study. in this respect, retroviruses came to the fore in the early 1900s with the demonstration by ellermann and bang and by rous that chicken leukosis was caused by a virus, now referred to as avian sarcoma/leukosis virus (aslv). this began a body of work that led to the identification of virus-induced tumors in mammalian species and re ... | 2004 | 14970611 |
| respiratory syncytial virus escape mutant derived in vitro resists palivizumab prophylaxis in cotton rats. | palivizumab (pz) is the only monoclonal antibody in human use against an infectious disease. pz is a humanized monoclonal antibody that recognizes the fusion protein of respiratory syncytial virus (rsv). pz prophylaxis reduces the likelihood of hospitalization for young children at risk for severe rsv infections. the quasispecies nature of rna viruses allows rapid emergence of viruses with a selective advantage. a pz resistant virus was selected by passage of rsv in the presence of pz in cell cu ... | 2004 | 14972528 |
| the wheezy infant -- immunological and molecular considerations. | most of the data on the pathogenesis of asthma is based on information obtained through bronchial biopsies and bronchoalveolar lavage in adults and young adults. ethical considerations linked to the invasive nature of airway endoscopy have limited the studies on the pathophysiology of asthma in infancy and early childhood. although there is evidence that an asthma-like inflammation, with increased inflammatory cells and thickening of the lung basement membrane, may be present also at a very earl ... | 2004 | 14980249 |
| respiratory syncytial virus: the virus, the disease and the immune response. | rsv is the primary cause of hospitalisation in the first year of life for children in most parts of the world, and nearly 100% of children in the usa are infected with the virus by 2 to 3 years of age. the agent is an enveloped rna virus with a non-segmented single-stranded negative-sense genome. the viral genome encodes 8 structural and 2 non-structural proteins. important structural proteins include the fusion (f) protein and the attachment (g) protein which are essential for viral penetration ... | 2004 | 14980256 |
| pathogenesis of respiratory syncytial virus bronchiolitis-related wheezing. | respiratory syncytial virus (rsv) is a common cause of virus infection of the human respiratory tract during the first two years of life, with virtually all children experiencing at least one infection within this period. although this usually leads to mild respiratory illness, some infants develop more severe disease (bronchiolitis, pneumonia, etc.) affecting the lower airways and frequently requiring hospitalisation. there is evidence that bronchiolitis hospitalisations have increased during t ... | 2004 | 14980267 |
| epidemiological and antigenic analysis of respiratory syncytial virus in hospitalised tunisian children, from 2000 to 2002. | human respiratory syncytial virus (rsv) is the major viral cause of lower respiratory tract disease in children. infections with the virus occur as annual winter epidemics in temperate climates, placing considerable pressure on the provision of hospital beds. most molecular epidemiological studies have, until now, focused on isolates from infants in industrialised countries. no data have been available with regard to rsv strains from northern africa. in this report, a recent rsv outbreak in tuni ... | 2004 | 14981774 |
| role of complement in neutralization of respiratory syncytial virus. | serum neutralizing antibody titers to respiratory syncytial virus (rsv) are higher when assayed with guinea pig complement. a number of different mechanisms have been suggested for enhancement of neutralization by complement. the most straightforward is that complement-antibody complexes present a greater steric hindrance to viral entry than with antibody alone. to define the implications of measuring serum neutralizing antibody with and without complement, sera from adults, young children, infa ... | 2004 | 14981775 |
| effect of zinc salts on respiratory syncytial virus replication. | zinc supplementation decreases the morbidity of lower respiratory tract infection in pediatric patients in the developing world. we sought to determine if zinc mediates a specific inhibitory effect against the major cause of pediatric lower respiratory tract disease, respiratory syncytial virus (rsv). we determined the in vitro inhibitory effect of three zinc salts (zinc acetate, lactate, and sulfate) on the replication of rsv at various concentrations of 10 and 1 mm and 100 and 10 microm. the d ... | 2004 | 14982765 |
| the v-src and c-src tyrosine kinases immunoprecipitated from rous sarcoma virus-transformed cells display different peptide substrate specificities. | in the cells transformed by rous sarcoma virus (rsv), two src proteins are expressed: the ubiquitous tyrosine kinase c-src and the v-src, the product of the transforming gene of the virus. using three synthetic peptide substrates widely used for testing src kinase activity, we show that they are phosphorylated with different efficiencies by the v-src and c-src tyrosine kinases immunoprecipitated from the tumor cell line h19. the v-src displays higher efficiency (vmax/km ratio) toward all three p ... | 2004 | 14984208 |
| treatment with anti-lfa-1 delays the cd8+ cytotoxic-t-lymphocyte response and viral clearance in mice with primary respiratory syncytial virus infection. | cytotoxic t lymphocytes (ctls) play an important role in the immune response against respiratory syncytial virus (rsv) infection. the cell surface molecule lymphocyte function-associated antigen 1 (lfa-1) is an important contributor to ctl activation, ctl-mediated direct cell lysis, and lymphocyte migration. in an attempt to determine the role of lfa-1 during rsv infection, we treated balb/c mice with monoclonal antibodies to lfa-1 at days -1, +1, and +4 relative to primary rsv infection. anti-l ... | 2004 | 14990720 |
| respiratory syncytial virus, pneumonia virus of mice, and influenza a virus differently affect respiratory allergy in mice. | respiratory viral infections in early childhood may interact with the immune system and modify allergen sensitization and/or allergic manifestations. in mice, respiratory syncytial virus (rsv) infection during allergic provocation aggravates the allergic t helper (th) 2 immune response, characterized by the production of il-4, il-5, and il-13, and inflammatory infiltrates. however, it is unclear whether the rsv-enhanced respiratory allergic response is a result of non-specific virus-induced dama ... | 2004 | 15005745 |
| concurrent serious bacterial infections in 912 infants and children hospitalized for treatment of respiratory syncytial virus lower respiratory tract infection. | the objective of this study was to report the frequency of concurrent serious bacterial infections in infants and young children hospitalized for treatment of respiratory syncytial virus (rsv) lower respiratory tract infection. data were collected through a retrospective review of the medical records of all 912 patients with a discharge diagnosis of rsv bronchiolitis or pneumonia between july 1, 2000 and june 30, 2002. two (0.43%) of 470 patients tested had a positive blood culture; both patient ... | 2004 | 15014307 |
| surfactant protein-d enhances phagocytosis and pulmonary clearance of respiratory syncytial virus. | surfactant protein (sp)-d gene targeted (sp-d-/-) and wild-type mice were infected with respiratory syncytial virus (rsv) by intratracheal instillation. decreased clearance of rsv was observed in sp-d-/- mice. deficiency of sp-d was associated with increased inflammation and inflammatory cell recruitment in the lung after infection. in vitro, sp-d bound rsv-infected vero cells. binding was inhibited with ethylenediamine tetraacetic acid and maltose, suggesting that the carbohydrate recognition d ... | 2004 | 15016617 |
| the value of virus serology in epidemiological studies of acute otitis media in children. | acute otitis media (aom) is a major health problem in young children. there is a general conception that aom is a bacterial disease but with the availability of sensitive diagnostic methods, it has gradually become evident that viruses play an important role in the pathogenesis of aom. paired blood samples are seldom taken from infants although valuable information could be obtained by serological methods. during the recent finnish otitis media (finom) cohort study, in addition to nasopharyngeal ... | 2004 | 15018861 |
| [treatment for viral respiratory infections: principles of action, strategies, and future prospects]. | pulmonary viral infections are associated with substantial morbidity and socioeconomic costs. rhinovirus, influenza a and b, adenovirus, parainfluenza, respiratory syncytial virus (rsv), and coronavirus are etiologies most often associated with infections of the upper and lower respiratory tract. therapy of viral infections in nonimmunocompromised hosts has only developed slowly during recent years, despite the enormous socioeconomic impact. this is in part due to the complex virus/host interact ... | 2004 | 15021931 |
| transaminase levels in ventilated children with respiratory syncytial virus bronchiolitis. | to compare disease severity as judged by duration of ventilation, inotrope use and mortality in children ventilated for respiratory syncytial virus (rsv)-positive lower respiratory tract infection (lrti) with and without elevated transaminase levels and to determine the aetiology of elevated transaminase levels in this patient group. | 2004 | 15024569 |
| opportunities for early therapy of respiratory syncytial virus (rsv) infection: what happens before hospitalization. | rsv loads of infants are already declining near the time of hospitalization. for optimal effect, antiviral and other rsv therapeutics therefore may need to be applied before this occurs. 134 rsv-hospitalized infants were studied to determine the timing of events and their healthcare seeking behavior prior to hospitalization. sixty-two percent of infants had contact with a health care professional > or = 1 day prior to hospitalization and 46% had such a contact on > or = 2 different days prior to ... | 2004 | 15026201 |
| a recombinant vaccinia virus encoding the interferon-inducible t-cell alpha chemoattractant is attenuated in vivo. | murine interferon-inducible t-cell alpha chemoattractant (i-tac) is a potent non-elr cxc chemokine that predominantly attracts activated t lymphocytes, binds to the receptor cxcr3 and is induced by interferon-gamma (ifn-gamma). we analysed i-tac expression by reverse transcriptase-polymerase chain reaction during three different virus-infection models in mice, respiratory syncytial virus (rsv), influenza a and vaccinia virus western reserve (vv-wr). in the lungs from mice infected with rsv or in ... | 2004 | 15030574 |
| bacteraemia and antibiotic use in respiratory syncytial virus infections. | to examine the frequency of and risk factors for bacteraemia in children hospitalised with respiratory syncytial virus (rsv) infection; and to determine current use of antibiotics in hospitalised children with rsv infection. | 2004 | 15033849 |
| advances in respiratory syncytial virus vaccine development. | respiratory syncytial virus (rsv) is the most important causative agent of respiratory tract infections. young children with chronic lung or congenital heart disease are at increased risk for severe disease. intensive research into a candidate vaccine has yielded live attenuated vaccines and subunit vaccines, which have been studied in humans. although immunogenic, occurrence of upper respiratory tract infection symptoms with live attenuated vaccine prohibits evaluation in young infants. subunit ... | 2004 | 15043390 |
| suppression of the induction of alpha, beta, and lambda interferons by the ns1 and ns2 proteins of human respiratory syncytial virus in human epithelial cells and macrophages [corrected]. | wild-type human respiratory syncytial virus (hrsv) is a poor inducer of alpha/beta interferons (ifn-alpha/beta). however, recombinant hrsv lacking the ns1 and ns2 genes (delta ns1/2) induced high levels of ifn-alpha and -beta in human pulmonary epithelial cells (a549) as well as in macrophages derived from primary human peripheral blood monocytes. results with ns1 and ns2 single- and double-gene-deletion viruses indicated that the two proteins function independently as well as coordinately to ac ... | 2004 | 15047850 |
| guidelines for preventing health-care--associated pneumonia, 2003: recommendations of cdc and the healthcare infection control practices advisory committee. | this report updates, expands, and replaces the previously published cdc "guideline for prevention of nosocomial pneumonia". the new guidelines are designed to reduce the incidence of pneumonia and other severe, acute lower respiratory tract infections in acute-care hospitals and in other health-care settings (e.g., ambulatory and long-term care institutions) and other facilities where health care is provided. among the changes in the recommendations to prevent bacterial pneumonia, especially ven ... | 2004 | 15048056 |
| intravenous ribavirin for eradication of respiratory syncytial virus (rsv) and adenovirus isolates from the respiratory and/or gastrointestinal tract in recipients of allogeneic hematopoietic stem cell transplants. | in a retrospective analysis, we identified 38 evaluable patients who received intravenous ribavirin after adenovirus or rsv detection in the respiratory and/or gastrointestinal tract throughout the years 1998 and 2001. a total of 43 treatment cycles are analyzed. intravenous ribavirin was combined with cidofovir in about half of the patients. in six out of eight patients treated because of rsv isolates from the respiratory tract, the virus was no longer detectable after treatment. in case of ade ... | 2004 | 15048064 |
| the role of toll-like receptor 4 versus interleukin-12 in immunity to respiratory syncytial virus. | toll-like receptors (tlr) and il-12 represent key elements of innate immunity. using c57bl/10 sccr mice it was shown that tlr4 is important for control of infection with respiratory syncytial virus (rsv). since these mice have an additional defect in the il-12r, we reinvestigated immunity to rsv in several c57bl/10 and balb/c mouse strains lacking a functional tlr4, a functional il-12-il-12r interaction or both. in the absence of a functional il-12 axis, early virus control was impaired in c57bl ... | 2004 | 15048726 |
| phenyl phosphoramidate derivatives of stavudine as anti-hiv agents with potent and selective in-vitro antiviral activity against adenovirus. | adenoviruses are responsible for a broad range of clinical diseases that may be associated with high mortality, including pneumonia, hepatitis, encephalitis, hemorrhagic cystitis, nephritis, and gastroenteritis in immunocompromised patients, including hiv-infected individuals. here we report the identification of halo-substituted stavudine phenyl phosphoramidate derivatives as a new class of dual-function anti-hiv agents with potent and selective anti-adenovirus (adv) activity. we examined the i ... | 2004 | 15051170 |
| interleukin 9 production in the lungs of infants with severe respiratory syncytial virus bronchiolitis. | respiratory syncytial virus (rsv) bronchiolitis is the most prevalent acute wheezing disorder in infants and is associated with recurrent wheeze and asthma in childhood. interleukin 9, a type 2 cytokine has been proposed as a key cytokine in susceptibility to asthma. we aimed to investigate whether interleukin 9 was produced in the lungs of infants with severe rsv disease and if found, from which cells it originated. | 2004 | 15051283 |
| role of serum neutralizing antibody in reinfection of respiratory syncytial virus. | to clarify the role of serum antibody in respiratory syncytial virus (rsv) reinfection, the authors conducted a follow-up study of patients with primary rsv infection. | 2004 | 15056236 |
| respiratory syncytial virus-related pneumonia after stem cell transplantation successfully treated with palivizumab and steroid therapy. | a case is reported of a 56-y-old woman with a second relapse of hodgkin's disease who early developed after autologous stem cell transplantation (asct) a severe rsv-related interstitial pneumonia successfully treated with 1-d intravenous palivizumab 8 mg/kg plus low-dose systemic steroid therapy. b-cells suppression with cmv antigenaemia were then observed and required treatment with ganciclovir and liposomal amfotericine b. | 2004 | 15061675 |
| economic impact of respiratory syncytial virus-related illness in the us: an analysis of national databases. | to determine the impact of respiratory syncytial virus (rsv) infection on healthcare resource use and costs in the us from the third-party payer perspective. | 2004 | 15061677 |
| practice variation among pediatric emergency departments in the treatment of bronchiolitis. | bronchiolitis is the most common disease of the lower respiratory tract in the first year of life. treatment is controversial, with studies giving conflicting views on the benefits of bronchodilators and steroids. the objectives of this study were 1) to characterize the management of bronchiolitis in pediatric emergency departments (peds) in canada, 2) to determine patient outcomes following emergency department (ed) visits, and 3) to provide descriptive data regarding bronchiolitis symptoms and ... | 2004 | 15064208 |
| control of nonsegmented negative-strand rna virus replication by sirna. | our laboratory provided the first proof-of-concept that double-stranded short interfering rna (ds-sirna) can act as potent and specific antiviral agents. designed against specific mrnas of nonsegmented negative-stranded rna (nnr) viruses, sirnas abrogated expression of the corresponding viral proteins, and generated the predicted viral phenotypes. knockdown was demonstrated across different genera: respiratory syncytial virus (rsv), a pneumovirus; vesicular stomatitis virus (vsv), a rhabdovirus; ... | 2004 | 15068877 |
| retention of the developmental pluripotency in medaka embryonic stem cells after gene transfer and long-term drug selection for gene targeting in fish. | embryonic stem (es) cells provide a unique tool for introducing random or targeted genetic alterations, because it is possible that the desired, but extremely rare recombinant genotypes can be screened by drug selection. es cell-mediated transgenesis has so far been limited to the mouse. in the fish medaka (oryzias latipes) several es cell lines have been made available. here we report the optimized conditions for gene transfer and drug selection in the medaka es cell line mes1 as a prelude for ... | 2004 | 15070074 |
| rapid and sensitive method using multiplex real-time pcr for diagnosis of infections by influenza a and influenza b viruses, respiratory syncytial virus, and parainfluenza viruses 1, 2, 3, and 4. | laboratory diagnosis of viral respiratory infections is generally performed by virus isolation in cell culture and immunofluorescent assays. reverse transcriptase pcr is now recognized as a sensitive and specific alternative for detection of respiratory rna viruses. a rapid real-time multiplex pcr assay was developed for the detection of influenza a and influenza b viruses, human respiratory syncytial virus (rsv), parainfluenza virus 1 (piv1), piv2, piv3, and piv4 in a two-tube multiplex reactio ... | 2004 | 15071005 |
| compliance with prophylaxis for respiratory syncytial virus infection in a home setting. | respiratory syncytial virus (rsv) is the most common respiratory pathogen in infancy and childhood. | 2004 | 15071285 |
| adenovirus and respiratory syncytial virus-adenovirus mixed acute lower respiratory infections in chilean infants. | in chile respiratory syncytial virus (rsv) and adenovirus (ad) are the principal viruses detected in acute lower respiratory infections (alri) in infants. an overview of ad pneumonia in chile to detect annual trends and to compare the severity of single ad or mixed rsv-ad infections is presented. | 2004 | 15071289 |
| surveillance of respiratory viral infections among pediatric outpatients in northern taiwan. | viruses are a frequent cause of upper respiratory tract infections in children. like taiwan, there were few virological surveillance systems for respiratory viral infections among children in developing countries. | 2004 | 15072759 |
| respiratory syncytial virus-induced chemokine production: linking viral replication to chemokine production in vitro and in vivo. | respiratory syncytial virus (rsv) is a negative-sense, single-strand rna virus that can initiate severe bronchiolitis in infants, as well as in elderly adults. although rsv preferentially infects and replicates in the airway epithelium, studies have shown that rsv has the ability to infect and, to a limited extent, replicate in alveolar macrophages. in the present study, we sought to characterize the rsv-induced chemokine production in vitro and in vivo, because chemokines have been shown to con ... | 2004 | 15073679 |
| importance of nosocomial respiratory syncytial virus infections in an african setting. | to define the importance of nosocomial-acquired respiratory syncytial virus (rsv) infection in an area with a high prevalence of paediatric hiv-1 infection. | 2004 | 15078268 |
| eosinophil activation and cysteinyl leukotriene production in infants with respiratory syncytial virus bronchiolitis. | it has been suggested that acute infantile bronchiolitis associated with respiratory syncytial virus (rsv) may share some pathogenic features with atopic asthma in that virus-specific ige is produced and cysteinyl leukotrienes (clts) and eosinophil cationic protein (ecp) have been detected in airway secretions. ecp is a specific marker of eosinophil activation although leukotrienes can be released from a variety of cells including mast cells, eosinophils and monocytes. | 2004 | 15080807 |
| development of a highly sensitive semi-quantitative real-time pcr and molecular beacon probe assay for the detection of respiratory syncytial virus. | molecular beacons are a novel class of oligonucleotide probe capable of reporting the accumulation of target amplicon during real-time pcr by the emission of a fluorescent signal. a novel assay for the detection and estimation of respiratory syncytial virus (rsv) nucleic acid in clinical specimens based on real-time pcr utilising such a probe was developed. the probe consisted of two short arm sequences and a central loop sequence complementary to a region of the n gene (the target amplicon). th ... | 2004 | 15081605 |
| increased in vivo transcription of an il-8 haplotype associated with respiratory syncytial virus disease-susceptibility. | interleukin-8 (il-8) has been implicated in the pathogenesis of rsv-induced bronchiolitis. previously, we have described an association between bronchiolitis disease severity and a specific il-8 haplotype comprising six single-nucleotide polymorphisms (snps) (-251a/+396g/+781t/+1238dela/+1633t/+2767t, haplotype 2). here we investigated the functional basis for this association by measuring haplotype-specific transcription in vivo in human primary cells. we found a significant increase in transcr ... | 2004 | 15085176 |
| formation and characterization of spontaneously formed heterokaryons between quail myoblasts and 3t3-l1 preadipocytes: correlation between differential plasticity and degree of differentiation. | skeletal muscle cells and adipose cells have a close relationship in developmental lineage. our previous study has shown that the heterokaryons between quail myoblasts and undifferentiated 3t3-l1 cells (preadipocytes) normally differentiated into myotubes, whereas the heterokaryons between myoblasts and differentiated 3t3-l1 cells (adipocytes) failed myogenic differentiation. these results suggest differences between preadipocytes and adipocytes. the purpose of this study was to clarify whether ... | 2004 | 15085954 |
| a sensitive, specific, and cost-effective multiplex reverse transcriptase-pcr assay for the detection of seven common respiratory viruses in respiratory samples. | cell culture and direct fluorescent antibody (dfa) assays have been traditionally used for the laboratory diagnosis of respiratory viral infections. multiplex reverse transcriptase polymerase chain reaction (m-rt-pcr) is a sensitive, specific, and rapid method for detecting several dna and rna viruses in a single specimen. we developed a m-rt-pcr assay that utilizes multiple virus-specific primer pairs in a single reaction mix combined with an enzyme-linked amplicon hybridization assay (elaha) u ... | 2004 | 15096568 |
| enhanced adherence of streptococcus pneumoniae to human epithelial cells infected with respiratory syncytial virus. | in the present study, we analyzed the effect of a preceding respiratory syncytial virus (rsv) infection of human respiratory epithelial cells on the adherence of streptococcus pneumoniae tested by means of a cytometric fluorescence assay. adherence of clinically relevant pneumococcal serotypes 3, 9, 14, 18, 19, and 23 was studied using uninfected and rsv-infected monolayers. to this end, monolayers of both human nasopharyngeal cells (hep-2) and pneumocyte type ii cells (a549) were infected with ... | 2004 | 15103015 |
| antiviral flavonoids from the seeds of aesculus chinensis. | a bioassay-guided fractionation of an ethanol extract of the seeds of aesculus chinensis led to the isolation of two new flavanoids (1 and 2), along with eight known ones (3-10). the structures of the new compounds were elucidated by spectroscopic methods including 2d nmr. all compounds were tested for antiviral activity against respiratory syncytial virus (rsv), parainfluenza virus type 3 (piv 3), and influenza virus type a (flu a). compounds 1, 2, and 6 showed significant antiviral activities ... | 2004 | 15104496 |
| efficacy of novel hemagglutinin-neuraminidase inhibitors bcx 2798 and bcx 2855 against human parainfluenza viruses in vitro and in vivo. | human parainfluenza viruses are important respiratory tract pathogens, especially of children. however, no vaccines or specific therapies for infections caused by these viruses are currently available. in the present study we characterized the efficacy of the novel parainfluenza virus inhibitors bcx 2798 and bcx 2855, which were designed based on the three-dimensional structure of the hemagglutinin-neuraminidase (hn) protein. the compounds were highly effective in inhibiting hemagglutinin (ha) a ... | 2004 | 15105096 |
| anti-respiratory syncytial virus (rsv) neutralizing antibody decreases lung inflammation, airway obstruction, and airway hyperresponsiveness in a murine rsv model. | numerous studies have described a strong association between respiratory syncytial virus (rsv) infection in infancy and the development of recurrent wheezing and airway hyperresponsiveness. we evaluated the effect of an anti-rsv neutralizing monoclonal antibody (palivizumab) on different aspects of rsv disease by using a murine model. balb/c mice were intranasally inoculated with rsv a2. palivizumab or an isotype-matched control antibody was administered once at 24 h before inoculation, 1 h afte ... | 2004 | 15105140 |
| the small hydrophobic (sh) protein accumulates within lipid-raft structures of the golgi complex during respiratory syncytial virus infection. | the cellular distribution of the small hydrophobic (sh) protein in respiratory syncytial virus (rsv)-infected cells was examined. although the sh protein was distributed throughout the cytoplasm, it appeared to accumulate in the golgi complex within membrane structures that were enriched in the raft lipid, gm1. the ability of the sh protein to interact with lipid-raft membranes was further confirmed by examining its detergent-solubility properties in triton x-100 at 4 degrees c. this analysis sh ... | 2004 | 15105532 |
| comparison of clinical characteristics of influenza and respiratory syncytial virus infection in hospitalised children and adolescents. | while significant morbidity due to respiratory syncytial virus (rsv) infection in the paediatric population has been well acknowledged, little is known about the burden of influenza in primarily healthy children in europe. in our institution, a university children's hospital in switzerland, medical staff were encouraged to take nasopharyngeal specimens for multiplex polymerase chain reaction assays for influenza a and b, rsv and several other pathogens from patients hospitalised with respiratory ... | 2004 | 15106003 |
| major histocompatibility (b) complex control of responses against rous sarcomas. | the chicken major histocompatibility (b) complex (mhc) affects disease outcome significantly. one of the best characterized systems of mhc control is the response to the oncogenic retrovirus, rous sarcoma virus (rsv). genetic selection altered the tumor growth pattern, either regressively or progressively, with the data suggesting control by one or a few loci. particular mhc genotypes determine rsv tumor regression or progression indicating the crucial b complex role in rous sarcoma outcome. ana ... | 2004 | 15109061 |
| influenza a common viral infection among hajj pilgrims: time for routine surveillance and vaccination. | the annual hajj pilgrimage to mecca, saudi arabia brings over two million people to a small confined area. respiratory tract infection is the most common disease transmitted during this period. for most of the etiologic agents of upper respiratory tract infections, no vaccine or prophylaxis is available, except for influenza. yearly influenza vaccination of high-risk groups is recommended, but no special recommendations are available for those performing the hajj or other similar large congregat ... | 2004 | 15109471 |
| rhoa-derived peptide dimers share mechanistic properties with other polyanionic inhibitors of respiratory syncytial virus (rsv), including disruption of viral attachment and dependence on rsv g. | large polyanionic molecules, such as sulfated polysaccharides (including soluble heparin and dextran sulfate), synthetic polyanionic polymers, and negatively charged proteins, have been shown to broadly inhibit several enveloped viruses. we recently reported the antiviral activity of a peptide derived from amino acids 77 to 95 of a potential binding partner of respiratory syncytial virus f protein (rsv f), the gtpase rhoa. a subsequent study with a truncated peptide (amino acids 80 to 94) reveal ... | 2004 | 15113882 |
| unspliced rous sarcoma virus genomic rnas are translated and subjected to nonsense-mediated mrna decay before packaging. | retroviruses package full-length, unspliced rnas into progeny virions as dimerized rna genomes. they also use unspliced rnas as mrnas to produce the gag and pol gene products. we asked whether a single rous sarcoma virus (rsv) rna can be translated and subsequently packaged or whether genomic packaging requires a nontranslated population of rnas. we addressed this issue by utilizing the translation-dependent nonsense-mediated mrna decay (nmd) pathway. nmd is the selective destruction of mrnas be ... | 2004 | 15113896 |
| optimizing long-term care by administration of influenza vaccine to parents of nicu patients. | the neonatal intensive care unit (nicu) team has traditionally invested itself in maintaining the health of its patients upon discharge from high-acuity care. historically, this has included the administration of vaccinations to the patients and more recently, palivizumab--a monoclonal antibody directed against respiratory synctial virus (rsv). with increasing awareness of the ill-effects associated with influenza virus and recommendations those in close contact with high-risk infants receive th ... | 2004 | 15116124 |
| respiratory syncytial virus induces pneumonia, cytokine response, airway obstruction, and chronic inflammatory infiltrates associated with long-term airway hyperresponsiveness in mice. | respiratory syncytial virus (rsv) infection is associated with acute morbidity (e.g., pneumonia and airway obstruction [ao]) and long-term complications (e.g., airway hyperresponsiveness [ahr]). we present a comprehensive evaluation of the acute and chronic phases of rsv respiratory tract infection, using a mouse model. | 2004 | 15122522 |
| timing of infection and prior immunization with respiratory syncytial virus (rsv) in rsv-enhanced allergic inflammation. | respiratory syncytial virus (rsv) infection has been shown to be a risk factor for the development of allergy in humans and mice. the allergy-enhancing properties of rsv may be dependent on atopic background and an individual's history of rsv infection. we examined the influence of the timing of infection and prior inoculation with rsv in a mouse model of allergic asthma. mice were sensitized to and challenged with ovalbumin (ova) and were inoculated with rsv either before or during the sensitiz ... | 2004 | 15122523 |
| production of interferon gamma in respiratory syncytial virus infection of humans is not associated with interleukins 12 and 18. | in order to understand early events in the immune response to respiratory syncytial virus (rsv) infection, we studied the presence of various chemokines and cytokines in respiratory secretions of human infants with rsv infection. interferon gamma (ifngamma) was present in 30/39 (76.9%) subjects tested, but the ifngamma-inducing cytokines interleukin (il)12 and il18 were detectable in 6/40 (15%) and 11/38 (28.9%) subjects, respectively. quantities of il12 and il18 did not correlate with those of ... | 2004 | 15122806 |
| age related differences in humoral immune response to respiratory syncytial virus infection in adults. | the humoral immune response to respiratory syncytial virus (rsv) was investigated in old and young adults. rsv was identified by culture and/or reverse transcription polymerase chain reaction (rt-pcr) in 52 elderly (mean age 74 years) and 15 young adults (mean age 33 years) with respiratory illness. preinfection serum neutralizing and binding antibody levels were similar in the two age groups, although older persons had significantly greater serum neutralizing responses to group a rsv (log(2) 2. ... | 2004 | 15122807 |
| inhibition of respiratory syncytial virus infection with the cc chemokine rantes (ccl5). | respiratory syncytial virus (rsv) is a major cause of respiratory tract disease in infants, aged adults, and immunosuppressed patients. the only approved medicines for rsv disease are administration of prophylatic antibodies or treatment with a synthetic nucleoside. both approaches are expensive and the latter is not without risk and of controversial benefit. the present investigation studied whether pharmaceutical or biologic compounds based upon chemokines might be useful in preventing rsv dis ... | 2004 | 15122808 |
| new drugs and treatment for respiratory syncytial virus. | the respiratory syncytial virus (rsv) is a global health problem affecting infants and the elderly and claiming more lives than aids in many parts of the world. only two antibody drugs are approved for its prevention, and ribavarin, a relatively nonspecific antiviral, is used for treatment. in the mid-1990s, a number of pharmaceutical and biotech companies initiated research programs against rsv. together, the academic and the industrial r&d covered the whole spectrum of antibodies, vaccines, sy ... | 2004 | 15124232 |
| antiviral drugs in current clinical use. | the current armamentarium for the chemotherapy of viral infections consists of 37 licensed antiviral drugs. for the treatment of human immunodeficiency virus (hiv) infections, 19 compounds have been formally approved: (i) the nucleoside reverse transcriptase inhibitors (nrtis) zidovudine, didanosine, zalcitabine, stavudine, lamivudine, abacavir and emtricitabine; (ii) the nucleotide reverse transcriptase inhibitor (ntrti) tenofovir disoproxil fumarate; (iii) the non-nucleoside reverse transcript ... | 2004 | 15125867 |
| evaluation of a multiplex reverse transcriptase pcr elisa for the detection of nine respiratory tract pathogens. | a multiplex reverse transcription (rt) polymerase chain reaction combined with a microwell hybridization assay (m-rt-pcr-elisa) was previously developed to detect nine different microorganisms: enterovirus (ev), influenza virus type a (iva) and type b (ivb), respiratory syncytial virus (rsv), parainfluenzavirus type 1 (piv1) and type 3 (piv3), adenovirus (av), mycoplasma pneumoniae (mpn), chlamydia pneumoniae (cpn) in a single test. these organisms do not usually colonize the respiratory tract o ... | 2004 | 15125873 |
| respiratory syncytial virus in allergic lung inflammation increases muc5ac and gob-5. | respiratory syncytial virus (rsv) is associated with wheezing and childhood asthma. we previously reported that rsv infection prolongs methacholine-induced airway hyperresponsiveness in ovalbumin (ova)-sensitized mice. in addition, allergically sensitized rsv-infected (ova/rsv) mice had more abundant airway epithelial mucus production compared with ova mice 14 days after infection, whereas there was almost no mucus in mice that were only rsv infected. we hypothesized that this increased mucus wa ... | 2004 | 15130904 |
| genetic variability and molecular epidemiology of respiratory syncytial virus subgroup a strains in japan determined by heteroduplex mobility assay. | we used heteroduplex mobility assay (hma) to determine the genetic variability of 118 respiratory syncytial virus (rsv) field isolates from 19 epidemics occurring in a japanese urban area between 1980 and 2000. nucleotides 1 to 584 of the attachment g glycoprotein gene were amplified by reverse transcription-pcr, and the pcr amplicons were analyzed by hma by using the earliest isolate from 1980 as the reference throughout. we also performed pcr-restriction fragment length polymorphism (rflp) ana ... | 2004 | 15131169 |
| impact of wheezing after respiratory syncytial virus infection on health-related quality of life. | respiratory syncytial virus (rsv) lower respiratory tract infection (lrti) is often followed by recurrent wheezing episodes during childhood. the effect of postbronchiolitis wheezing on the well-being of the child is not known. this study aimed to determine the impact of rsv lrti hospitalization before age 13 months on health-related quality of life (hrqol) at age 3 years. | 2004 | 15131463 |
| driscoll children's hospital respiratory syncytial virus database: risk factors, treatment and hospital course in 3308 infants and young children, 1991 to 2002. | treatment of respiratory syncytial virus (rsv) lower respiratory tract infection has historically been one of the most frequent reasons for admission to driscoll children's hospital. | 2004 | 15131464 |
| [the anti-respiratory syncytial virus effect of an active compound (ap3) from a chinese medicinal herb-herba patriniae in vitro]. | to study the effect on anti-respiratory syncytial virus of an active compound (ap3) from a chinese medicinal herb-herba patriniae in vitro. | 2004 | 15132871 |
| human metapneumovirus as a causative agent of acute bronchiolitis in infants. | human metapneumovirus (hmpv), has been recently isolated from children with acute respiratory tract infections (rtis), including bronchiolitis, and classified in the pneumovirinae subfamily within the paramyxoviridae family. | 2004 | 15135747 |