Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| transcriptional regulation of an iron-inducible gene by differential and alternate promoter entries of multiple myb proteins in the protozoan parasite trichomonas vaginalis. | iron-inducible transcription of a malic enzyme gene (also reputed to be ap65-1) in trichomonas vaginalis was previously shown to involve a myb1 repressor and a myb2 activator, each of which may preferentially select two closely spaced promoter sites, mre-1/mre-2r, which comprises overlapping promoter elements, and mre-2f. in the present study, an iron-inducible approximately 32-kda myb3 nuclear protein was demonstrated to bind only the mre-1 element. changes in the iron supply, which produced an ... | 2009 | 19151329 |
| identification and molecular characterization of numerous histomonas meleagridis proteins using a cdna library. | summaryhistomonas meleagridis is a protozoan parasite of various galliform birds causing a type of enterohepatitis termed histomonosis or 'blackhead disease'. due to the ban of chemotherapeutic substances and an increase in free-range poultry production, histomonosis is currently a re-emerging disease. so far limited molecular knowledge is available. in the present work, mrnas coding for antigenic proteins of h. meleagridis were identified. for this purpose, a cdna expression library was constru ... | 2009 | 19154645 |
| the effects of male circumcision on female partners' genital tract symptoms and vaginal infections in a randomized trial in rakai, uganda. | the objective of the study was to assess effects of male circumcision on female genital symptoms and vaginal infections. | 2009 | 18976733 |
| differential inhibition of high and low mr thioredoxin reductases of parasites by organotelluriums supports the concept that low mr thioredoxin reductases are good drug targets. | thioredoxin reductase (trxr), a nadph-dependent disulfide oxidoreductase, is vital in numerous cellular processes including defence against reactive oxygen species, cell proliferation and signal transduction. trxrs occur in 2 forms, a high mr enzyme characterized by those of mammals, the malaria parasite plasmodium falciparum and some worms, and a low mr form is present in bacteria, fungi, plants and some protozoan parasites. our hypothesis is that the differences between the forms can be exploi ... | 2009 | 18980703 |
| stepwise diagnosis of trichomonas vaginalis infection in adolescent women. | the objective of this study was to examine the effects of clinical factors and of the type and timing of a secondary test in improving the sensitivity of trichomonas vaginalis detection in young women over that of a wet mount alone. for this purpose, sexually active adolescent women (n = 345) were recruited from a hospital teen clinic or emergency department. following an interview and a pelvic exam, four primary t. vaginalis tests (wet mount, culture, a rapid test, and a nucleic acid amplificat ... | 2009 | 18987174 |
| giardia, entamoeba, and trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases). | infections with giardia lamblia, entamoeba histolytica, and trichomonas vaginalis, which cause diarrhea, dysentery, and vaginitis, respectively, are each treated with metronidazole. here we show that giardia, entamoeba, and trichomonas have oxygen-insensitive nitroreductase (ntr) genes which are homologous to those genes that have nonsense mutations in metronidazole-resistant helicobacter pylori isolates. entamoeba and trichomonas also have nim genes which are homologous to those genes expressed ... | 2009 | 19015349 |
| microbiological and toxicological effects of perla black bean (phaseolus vulgaris l.) extracts: in vitro and in vivo studies. | we investigated the microbiological and toxicological effects of three perla black bean extracts on the growth and culture of selected pathogenic microorganisms, the toxicity over vero cell lines and an in vivo rat model. three different solvents were used to obtain perla black bean extracts. all three perla black bean extracts were tested for antibacterial and antiparasitic activity and further analysed for intrinsic cytotoxicity (ic(50)). methanol perla black bean extract was used for acute to ... | 2009 | 19053992 |
| a proteome reference map of trichomonas vaginalis. | trichomoniasis caused by trichomonas vaginalis is the most common sexual transmitted infection in the world. the 170-mb genome of this protozoan contains 60,000 genes, the largest number of genes ever identified in protozoan. high-throughput expression sequenced tag analysis showed that at least 4,000 genes were expressed in the trophozoite stage. in the present study, we use two-dimensional electrophoresis combined with matrix-assisted laser desorption ionization time-of-flight mass spectrometr ... | 2009 | 19066965 |
| male circumcision and neisseria gonorrhoeae, chlamydia trachomatis and trichomonas vaginalis: observations after a randomised controlled trial for hiv prevention. | to assess the association between male circumcision and neisseria gonorrhoeae, chlamydia trachomatis and trichomonas vaginalis using data from a male circumcision randomised controlled trial. | 2009 | 19074928 |
| in vitro testing of rationally designed spermicides for selectively targeting human sperm in vagina to ensure safe contraception. | rational synthesis of novel structures resulted in two unique molecules (dse-36 and dse-37, disulphide esters of carbothioic acid) that killed sperm 25 times more strongly and with a precisely targeted action than nonoxynol-9 (n-9). we examine the effects of dse-36 and dse-37 on human spermatozoa versus hela cells to establish specificity and safety compared with n-9. | 2009 | 19088111 |
| an iatrogenic confounding variable. | 2009 | 19741210 | |
| prospective study of trichomonas vaginalis infection and prostate cancer incidence and mortality: physicians' health study. | a recent nested case-control study found that the presence of antibodies against trichomonas vaginalis, a common nonviral sexually transmitted infection, was positively associated with subsequent incidence of prostate cancer. we confirmed these findings in an independent population and related serostatus for antibodies against t vaginalis to prostate cancer incidence and mortality. | 2009 | 19741211 |
| anti-trichomonas vaginalis activity of synthetic lipophilic diamine and amino alcohol derivatives. | taking in account the increased prevalence of metronidazole-resistant infections, alternative drugs are necessary for the treatment of trichomonosis. we report in this work the preparation and the in vitro anti-trichomonads activity of two diamines 1 and 2, and three different lipophilic amino alcohol derivatives 3, 4 and 5. these compounds were tested for in vitro activity against two isolates of trichomonas vaginalis and displayed inhibition of the parasite growth. five concentrations of each ... | 2009 | 19013752 |
| flavodiiron protein from trichomonas vaginalis hydrogenosomes: the terminal oxygen reductase. | trichomonas vaginalis is one of a few eukaryotes that have been found to encode several homologues of flavodiiron proteins (fdps). widespread among anaerobic prokaryotes, these proteins are believed to function as oxygen and/or nitric oxide reductases to provide protection against oxidative/nitrosative stresses and host immune responses. one of the t. vaginalis fdp homologues is equipped with a hydrogenosomal targeting sequence and is expressed in the hydrogenosomes, oxygen-sensitive organelles ... | 2009 | 19011120 |
| trichomonas vaginalis treatment reduces vaginal hiv-1 shedding. | vaginal hiv-1 shedding has been associated with trichomonas vaginalis (tv) infection and could play a role in hiv transmission. the purpose of the study was to examine if effective tv treatment reduces the presence of vaginal hiv-1 rna. | 2009 | 19008776 |
| phase ii clinical trial with praneem polyherbal tablets for assessment of their efficacy in symptomatic women with abnormal vaginal discharge (an icmr task force study). | abnormal vaginal discharge syndrome (avds) is a commonly observed gynaecological complaint for which women seek medical attention. the present study was conducted in six indian council of medical research centres with praneem polyherbal tablets (ppt), to determine their efficacy in the treatment of symptomatic women with avds. data are given on 141 subjects investigated. in total, 137 women (97%) reported complete (n=62, 44%) and partial (n=75, 53%) relief from symptoms after use of ppt for seve ... | 2009 | 18990416 |
| trichomonal sinusitis in an adolescent patient with multiple trauma. | trichomonal disease typically involves the genital and occasionally respiratory tracts. although exposure of the upper respiratory tract to infected genital secretions is not uncommon with contemporary sexual practices, trichomonal sinus disease has been rarely described. the present report describes the case of a healthy 17-year-old male admitted to an intensive care unit following multiple trauma, who developed purulent sinusitis on the 4th day of hospitalization. numerous trichomonads were no ... | 2009 | 19204647 |
| synthesis and in vitro trichomonicidal, giardicidal and amebicidal activity of n-acetamide(sulfonamide)-2-methyl-4-nitro-1h-imidazoles. | two new series of imidazole derivatives (acetamides: 1-8 and sulfonamides: 9-15) were synthesized using a short synthetic route. compound 1 as well as the intermediate 16g were characterized by x-ray crystallography. imidazole derivatives 1-15 were tested in vitro against three unicellular parasites (giardia intestinalis, trichomonas vaginalis and entamoeba histolytica) in comparison with benznidazole (bzn) and metronidazole. compound 1 [n-benzyl-2-(2-methyl-4-nitro-1h-imidazol-1-yl)acetamide] w ... | 2009 | 19208443 |
| synthesis and biological evaluation of new heterocyclic quinolinones as anti-parasite and anti-hiv drug candidates. | we have synthesized quinolinones with potential antiparasitic and anti-hiv activities by an original two-step method involving microwave irradiation and have evaluated their activities against plasmodium falciparum, leishmania donovani, trichomonas vaginalis, and hiv. none of the tested compounds had been previously described using this method of synthesis. one of the compounds had interesting antiparasitic and anti-hiv activity, which could be improved by substitution with different radicals. | 2009 | 19748781 |
| steroid hormones alter amp hydrolysis in intact trophozoites of trichomonas vaginalis. | trichomonas vaginalis infection may be influenced by the vaginal concentrations of estrogens. we have investigated the effects of 17beta-estradiol and dehydroepiandrosterone sulfate (dheas) on the ecto-5'-nucleotidase activity in fresh clinical (vp60) and in long-term-grown (30236 atcc) isolates of t. vaginalis. in vitro exposure to dheas and 17beta-estradiol did not induce any changes in adenosine monophosphate (amp) hydrolysis in these isolates. the treatment of parasites in the presence of dh ... | 2009 | 19756747 |
| the evolution of an integrated sexual health service. | the objective of the study was to assess the contributions of different providers across an integrated sexual health-care network to the diagnosis of sexually transmitted infections (stis). the method employed was retrospective cross-sectional survey of laboratory tests for chlamydia trachomatis, neisseria gonorrhoeae and trichomonas vaginalis between 01 april 2004 and 31 march 2007. the total number of sti screens in all venues rose from 17,126 to 23,679. the proportion of sti screens occurring ... | 2009 | 19759047 |
| the mercaptopyruvate sulfurtransferase of trichomonas vaginalis links cysteine catabolism to the production of thioredoxin persulfide. | trichomonas vaginalis is a protozoan parasite of humans that is able to synthesize cysteine de novo using cysteine synthase but does not produce glutathione. in this study, high pressure liquid chromatography analysis confirmed that cysteine is the major intracellular redox buffer by showing that t. vaginalis contains high levels of cysteine ( approximately 600 mum) comprising more than 70% of the total thiols detected. to investigate possible mechanisms for the regulation of cysteine levels in ... | 2009 | 19762467 |
| proinflammatory cytokine and nitric oxide production by human macrophages stimulated with trichomonas vaginalis. | trichomonas vaginalis commonly causes vaginitis and perhaps cervicitis in women and urethritis in men and women. macrophages are important immune cells in response to t. vaginalis infection. in this study, we investigated whether human macrophages could be involved in inflammation induced by t. vaginalis. human monocyte-derived macrophages (hmdm) were co-cultured with t. vaginalis. live, opsonized-live trichomonads, and t. vaginalis lysates increased proinflammatory cytokines, such as tnf-alpha, ... | 2009 | 19724692 |
| trichomoniasis and other sexually transmitted infections: results from the 2001-2004 national health and nutrition examination surveys. | to estimate the association between trichomonas vaginalis infection (tv) and 6 sexually transmitted infections: chlamydia, gonorrhea, herpes simplex virus (types 1 and 2), syphilis, and human immunodeficiency virus (hiv) in a nationally representative sample. | 2009 | 19734826 |
| malate dehydrogenase is negatively regulated by mir-1 in trichomonas vaginalis. | micrornas are highly conserved small noncoding rnas that can suppress protein translation through complementary binding to target mrnas. we used a novel approach to identify mirna targets in the protist trichomonas vaginalis by comparing the levels of differentially expressed proteins and genes in the trophozoite and amoeboid stages. we observed that the t. vaginalis malate dehydrogenase (tv_mdh) gene was upregulated 20-fold in the amoeboid stage, but the protein level was reduced by 4.5-fold. b ... | 2009 | 19777264 |
| molecular characterization of trichomonas vaginalis isolates from the philippines. | trichomonas vaginalis is a human urogenital pathogen that causes trichomoniasis, the most common nonviral parasitic sexually transmitted infection in the world. presently, there are no reports on comparative sequence analysis as well as on the identification of phylogenetic positions of t. vaginalis isolates from the philippines relative to known trichomonads. in this study, 5.8s rdna and the flanking internal transcribed spacer (its) regions of 57 t. vaginalis isolates were sequenced. the phylo ... | 2009 | 19779740 |
| idiopathic urethritis in young men in the united states: prevalence and comparison to infections with known sexually transmitted pathogens. | urethritis is the most common male reproductive tract disease syndrome; yet 20-50% of diagnosed cases have no defined etiology, and few population-level data exist on the prevalence or etiology of the syndrome. we estimated the prevalence of urethritis among young men in the united states and compared correlates of idiopathic cases to correlates of detected infections with sexually transmitted pathogens. | 2009 | 19837352 |
| partial purification and characterization of trichomonas vaginalis dna topoisomerase ii. | dna topoisomerases regulate conformational changes in dna topology by catalyzing the breakage and rejoining of dna strands during the cell cycle. these processes are essential for the multiplication of cells, and inhibition of these reactions stops cell division and cell growth. drug resistance to trichomonas vaginalis, a common sexually transmitted protozoan parasite, is increasing worldwide, and dna topoisomerase ii may provide a new target for anti-trichomonal drug development. in this study, ... | 2009 | 19842367 |
| the prevalence of sexually transmitted and other lower reproductive tract infections among rural women in sichuan province, china. | to estimate the prevalence of sexually transmitted infections (sti) and lower reproductive tract infections (rti) and determine risk factors for sti among rural women in sichuan province, china, a cross-sectional, community-based cluster sample of 2,000 rural, married women were interviewed, examined and clinical specimens collected to assess for six sti and two non-sexually transmitted rti. the overall prevalence of any sti was 10.9% (95% ci 9.5-12.3); of any sti or rti was 30.8% (95% ci 28.7-3 ... | 2009 | 19842387 |
| impact of t. vaginalis infection on innate immune responses and reproductive outcome. | trichomonas vaginalis is the most common non-viral sexually transmitted pathogen. the infection is prevalent in reproductive age women and is associated with vaginitis, endometritis, adnexitis, pyosalpinx, infertility, preterm birth, low birth weight, bacterial vaginosis, and increased risk of cervical cancer, hpv, and hiv infection. in men, its complications include urethritis, prostatitis, epididymitis, and infertility through inflammatory damage or interference with the sperm function. the in ... | 2009 | 19850356 |
| [in vitro effect of secnidazole benzoate on trichomonas vaginalis]. | to research the trichomonacidal effect of secnidazole benzoate in vitro. | 2009 | 19856497 |
| methionine gamma-lyase: the unique reaction mechanism, physiological roles, and therapeutic applications against infectious diseases and cancers. | sulfur-containing amino acids (saas) are essential components in many biological processes and ubiquitously distributed to all organisms. both biosynthetic and catabolic pathways of saas are heterogeneous among organisms and between developmental stages, and regulated by the environmental changes. limited lineage of organisms ranging from archaea to plants, but not human, possess a unique enzyme methionine gamma-lyase (mgl, ec 4.4.1.11) to directly degrade saa to alpha-keto acids, ammonia, and v ... | 2009 | 19859976 |
| maternal morbidity in the first year after childbirth in mombasa kenya; a needs assessment. | in sub-saharan africa, few services specifically address the needs of women in the first year after childbirth. by assessing the health status of women in this period, key interventions to improve maternal health could be identified. there is an underutilised opportunity to include these interventions within the package of services provided for woman-child pairs attending child-health clinics. | 2009 | 19891784 |
| use of injectable progestin contraception and risk of sti among south african women. | this study was conducted to determine the association between the use of injectable progestin contraception (ipc) and the risk of infection with neisseria gonorrhoeae (gc), chlamydia trachomatis (ct), bacterial vaginosis (bv) and trichomonas vaginalis (tv) among women in south africa. | 2009 | 19913149 |
| metronidazole resistance in trichomonas vaginalis from highland women in papua new guinea. | the prevalence of the sexually transmissible protozoan parasite trichomonas vaginalis in the highlands of papua new guinea (png) has been reported to be as high as 46% and although not previously studied in papua new guinea, clinical resistance against metronidazole (mz), the drug most commonly used to treat trichomoniasis, is well documented worldwide. this study was primarily aimed at assessing resistance to mz in t. vaginalis strains from the goroka region. | 2009 | 19917203 |
| prevalence of trichomonas vaginalis infection among young reproductive age women in india: implications for treatment and prevention. | trichomonas vaginalis infection is the most common curable sexually transmissible infection (sti) worldwide. the present study describes the burden and correlates of t. vaginalis infection among young reproductive age women in mysore, india. | 2009 | 19917204 |
| treatment of metronidazole-resistant trichomonas vaginalis. | a 58-year-old caucasian woman presented with a 14-month history of persistent trichomoniasis not responsive to numerous courses of metronidazole and tinidazole. vaginal secretion samples were obtained for sensitivity testing and treatment recommendations. in vitro susceptibility testing revealed the patient's trichomonas vaginalis isolate was highly resistant to both metronidazole and tinidazole. she was treated with topical furazolidone and experienced a complete symptomatic cure and culture re ... | 2009 | 19917205 |
| prevalence of sexually transmitted infections among female adolescents aged 14 to 19 in the united states. | most young women initiate sexual activity during adolescence; risk for sexually transmitted infections (stis) accompanies this initiation. in this study we estimated the prevalence of the most common stis among a representative sample of female adolescents in the united states. | 2009 | 19933728 |
| trichomonas vaginalis is highly prevalent in adolescent girls, pregnant women, and commercial sex workers in ndola, zambia. | objectives:: the aim of the study was to assess the prevalence of trichomonas sp. infection among adolescent girls, pregnant women, and commercial sex workers in ndola, zambia. methods:: a cross-sectional study was conducted among 460 girls attending school, 307 pregnant women, and 197 commercial sex workers. self-collected specimens from the vagina, rectum, and mouth were tested by polymerase chain amplification assays for the presence of trichomonas vaginalis, pentatrichomonas hominis, and tri ... | 2009 | 19940808 |
| comparison of clinical symptoms scored according to the national institutes of health chronic prostatitis symptoms index and assessment of antimicrobial treatment in patients with chronic prostatitis syndrome. | we examined a total of 194 patients over 18 years of age with chronic prostatitis syndrome and no evidence of structural or functional lower genitourinary tract abnormalities. the following data were obtained for each patient: clinical history--the severity of chronic prostatitis symptoms scored by a croatian translation of the nih cpsi questionnaire, clinical status including digitorectal examination, urethral swab specimens, and selective samples of urine and expressed prostatic secretion, acc ... | 2009 | 19423471 |
| disentangling contributions of reproductive tract infections to hiv acquisition in african women. | : to estimate the effects of reproductive tract infections (rtis) on hiv acquisition among zimbabwean and ugandan women. | 2009 | 19434010 |
| identification of microrna in the protist trichomonas vaginalis. | micrornas (mirnas) are a class of small noncoding rnas that have important regulatory roles in multicellular organisms. however, mirna has never been identified experimentally in protist. direct cloning of 438 expressed mirna tags by microrna serial analysis of gene expression from the parasitic protist trichomonas vaginalis identified nine candidate mirnas. bioinformatics analysis of the corresponding genomic region revealed that these mirna candidates contain a classical stem-loop-stem structu ... | 2009 | 19442639 |
| examination for double-stranded rna viruses in trichomonas gallinae and identification of a novel sequence of a trichomonas vaginalis virus. | to determine if double-stranded rna (dsrna) viruses exist and are potential virulence factors in trichomonas gallinae, virus purification via ultracentrifugation was attempted for 12 t. gallinae isolates recovered from wild birds. following purification, virus-like particles were not observed by transmission electron microscopy, nor were dsrna segments visualized in agarose gels after electrophoresis of extracted rna from any of the 12 t. gallinae isolates. however, virus particles and dsrna seg ... | 2009 | 19452169 |
| anal sex is a behavioural marker for laboratory-confirmed vaginal sexually transmissible infections and hiv-associated risk among african-american female adolescents. | african-american females are disproportionately affected by hiv and sexually transmissible infections (stis). the prevalence of anal sex and its association with other sexual risk behaviours is understudied in this population. | 2009 | 19457289 |
| in vitro activities of three synthetic peptides derived from epinecidin-1 and an anti-lipopolysaccharide factor against propionibacterium acnes, candida albicans, and trichomonas vaginalis. | the synthetic epinecidin-1(22-42) peptide was derived from positions 22-42 of epinephelus coioides epinecidin-1. the synthetic salf(55-76) cyclic peptide (cssalf(55-76)) and salf(55-76) linear peptide (lssalf(55-76)) contained sequences from positions 55 to 76 of the penaeus monodon anti-lipopolysaccharide factor (alf), respectively. we studied the in vitro activities of epinecidin-1(22-42), cssalf(55-76), and lssalf(55-76) against propionibacterium acnes, candida albicans, and trichomonas vagin ... | 2009 | 19463737 |
| bacterial vaginosis in female facility workers in north-western tanzania: prevalence and risk factors. | to determine prevalence of, and risk factors for, bacterial vaginosis (bv) among herpes simplex virus (hsv) 2 seropositive tanzanian women at enrollment into a randomised, placebo-controlled trial of hsv suppressive treatment. | 2009 | 19473997 |
| trichomoniasis in teens: an update. | trichomoniasis, caused by the protozoa trichomonas vaginalis, is one of the oldest sexually transmitted infections. since the advent of more accurate diagnostic tests, the epidemiology and consequences of infection with t. vaginalis can be described more precisely. this review will highlight new diagnostic methods, the epidemiology of trichomoniasis, and discuss the merits of improved screening for this pathogen in adolescent women. | 2009 | 19491679 |
| a study comparing sexually transmitted infections and hiv among ex-red-light district and non-red-light district sex workers after the demolition of baina red-light district. | in june 2004, the red-light area of goa was demolished. we compare hiv and sexually transmitted infections (stis) between sex workers who had been based in baina red-light district (ex-rld-sws) with sex workers who had never worked in baina (non-rld-sws). | 2009 | 19525855 |
| [leucoplakia vesicae in females: diagnosis and treatment]. | sixty patients suffering from leucoplakia vesicae (lv) were examined using cystoscopy with biopsy of the urinary bladder wall, blood enzyme immunoassay for detection of antibodies to agents of sexually transmitted infections (sti), uroflowmetry, culture analysis of cervical canal and mucosa samples for sti. as shown by a pathomorphological examination of the vesical mucosa biopsy specimens, long-term persistence of pathogenic (chlamydia, trichomonades) and opportunistic (mycoplasma, ureaplasma, ... | 2009 | 19526870 |
| polymerase chain reaction versus conventional methods in the diagnosis of vaginal trichomoniasis. | a total of 200 females of whom 120 had manifestations of vaginal trichomoniasis and 80 asymptomatic ones were studied. in 54/120 symptomatic female (45%) and in 28/80 asymptomatic ones (35%), t. vaginalis was diagnosed by wet mount of bedside vaginal swab samples. of 120 samples from symptomatic females, t. vaginalis was detected in 93 (77.5%) when cultured onto inpouch & 95 (79.16%) in modified thioglycolate media. culturing 80 samples of asymptomatic females showed t. vaginalis in 35 (43.75%) ... | 2009 | 19530606 |
| efficacy of two plant extracts against vaginal trichomoniasis. | trichomoniasis vaginalis is now an important worldwide health problem. metronidazole has so far been used in treatment, but the metronidazole-resistant strains and unpleasant adverse effects have been developed. treatment of patients with metronidazole refractory vaginal trichomoniasis constitutes a major therapeutic challenge and treatment options are extremely limited. in the present study, 33 metronidazole-resistant t. vaginalis females were treated with a combined course of metronidazole and ... | 2009 | 19530609 |
| responsiveness of trichomonas vaginalis to iron concentrations: evidence for a post-transcriptional iron regulation by an ire/irp-like system. | trichomonas vaginalis has high iron-dependency, favoring its growth and multiplication in culture. iron also regulates some of the trichomonal virulence properties by yet unknown mechanisms. iron is an essential but potentially toxic metal for the majority of organisms. thus, its concentration must be tightly regulated within the cell. in mammals, the iron homeostasis is mainly regulated at the post-transcriptional level by a well known mechanism mediated by the binding of iron regulatory protei ... | 2009 | 19539055 |
| [tinidazole: a classical anaerobical drug with multiple potential uses nowadays]. | tinidazole is a 5-nitroimidazole active in vitro against a wide variety of anaerobic bacteria and protozoa. tinidazole is an effective treatment against anaerobic microorganisms based on its pharmacokinetic characteristics (c(max) 51 microg/ml, t(1/2) 12.5 h) and its excellent in vitro activity. its long half-life allows once a day regimens. tinidazole is as effective as metronidazole in the treatment of infections caused by t. vaginalis, giardiasis and amebiasis and bacterial vaginosis, malaria ... | 2009 | 19544102 |
| adult male circumcision does not reduce the risk of incident neisseria gonorrhoeae, chlamydia trachomatis, or trichomonas vaginalis infection: results from a randomized, controlled trial in kenya. | we examined the effect of male circumcision on the acquisition of 3 nonulcerative sexually transmitted infections (stis). | 2009 | 19545209 |
| redox properties of the oxygen-detoxifying flavodiiron protein from the human parasite giardia intestinalis. | flavodiiron proteins (fdps) are enzymes identified in prokaryotes and a few pathogenic protozoa, which protect microorganisms by reducing o(2) to h(2)o and/or no to n(2)o. unlike most prokaryotic fdps, the protozoan enzymes from the human pathogens giardia intestinalis and trichomonas vaginalis are selective towards o(2). uv/vis and epr spectroscopy showed that, differently from the no-consuming bacterial fdps, the giardia fdp contains an fmn with reduction potentials for the formation of the si ... | 2009 | 19545535 |
| the association between oral contraceptives, depot-medroxyprogesterone acetate, and trichomoniasis. | hormonal contraception use by women may increase the risk of acquiring certain sexually transmitted infections. we explored the effect of hormonal contraceptive use, specifically oral contraception (oc), and depot-medroxyprogesterone acetate (dmpa) on trichomonas vaginalis infections in women. | 2009 | 19556926 |
| vaginal and endocervical microorganisms in symptomatic and asymptomatic non-pregnant females: risk factors and rates of occurrence. | physiological or non-physiological factors may affect the vaginal flora. the occurrence of genital microorganisms in non-pregnant females of all ages was studied, as were the risk factors associated with each microorganism. a retrospective analysis of vaginal and endocervical cultures and wet smears from 27,172 non-pregnant women, between 1996 to 2005, was performed taking into consideration clinical and socio-demographic characteristics. no microorganisms were observed in 55.7% of the individua ... | 2009 | 19558525 |
| epidemiology of sexually transmitted infections in suspected child victims of sexual assault. | the objective of this study was to describe the epidemiology of neisseria gonorrhoeae, chlamydia trachomatis, trichomonas vaginalis, treponema pallidum, hiv, and herpes simplex virus type 2 (hsv-2) infection diagnosed by culture or by serologic or microscopic tests and by nucleic acid amplification tests in children who are evaluated for sexual victimization. | 2009 | 19564286 |
| diagnosis of trichomonas vaginalis in female children and adolescents evaluated for possible sexual abuse: a comparison of the inpouch tv culture method and wet mount microscopy. | to compare the performance of wet mount microscopy and the inpouch tv culture method in diagnosing trichomonas vaginalis in a cohort of female children and adolescents evaluated for possible sexual abuse. | 2009 | 19576816 |
| depression, sexually transmitted infection, and sexual risk behavior among young adults in the united states. | to measure associations among depression, sexual risk behaviors, and sexually transmitted infection (sti) among white and black youth in the united states. | 2009 | 19581548 |
| trichomonas vaginalis infection and associated risk factors in a socially-marginalized female population in coastal peru. | the epidemiology of trichomonas vaginalis infection among sexually active socially-marginalized women in three urban, coastal peruvian cities was examined in order to quantify the prevalence of trichomonas infection and identify associated risk factors. | 2009 | 19584943 |
| a quantitative resazurin assay to determinate the viability of trichomonas vaginalis and the cytotoxicity of organic solvents and surfactant agents. | trichomonas vaginalis causes trichomonosis, the most common, non-viral sexually transmitted disease. to test anti-trichomonas agents, usually many with low water solubility, organic solvents and surfactant agents should be used. therefore, the minimal inhibitory concentration (mic) of acetone, methanol, ethanol, isopropanol, dmso, tween 20, tween 80, and triton x-100 was determined against t. vaginalis isolates using the quantitative resazurin method. our results showed that solvents and surfact ... | 2009 | 19619538 |
| the protist trichomonas vaginalis harbors multiple lineages of transcriptionally active mutator-like elements. | for three decades the mutator system was thought to be exclusive of plants, until the first homolog representatives were characterized in fungi and in early-diverging amoebas earlier in this decade. | 2009 | 19622157 |
| physical health consequences of sexual assault victims. | to describe health consequences of sexual assault victims attending police general hospital, thailand. | 2009 | 19626805 |
| correlates of sexually transmitted infection histories in a cohort of american male health professionals. | several epidemiologic studies have investigated sexually transmitted infections (stis) and later risk of genitourinary conditions with suggestive positive results. while these results may reflect causal associations, other possible explanations include confounding by factors possibly related to both sti acquisition and genitourinary condition risk such as recognized sti-risk factors/correlates, and other factors not typically considered in relation to stis (e.g., general health-related behaviors ... | 2009 | 19655261 |
| mycoplasma genitalium as a contributor to the multiple etiologies of cervicitis in women attending sexually transmitted disease clinics. | the purpose of this study was to investigate the prevalence of chlamydia trachomatis, neisseria gonorrhoeae, trichomonas vaginalis, and mycoplasma genitalium, in women attending a sexually transmitted disease (std) clinic, as well as the frequency of coinfections, and relationship of each organism to cervicitis. | 2009 | 19704398 |
| validity of the symptomatic approach used by nurses in diagnosing vaginal infections. | to examine the validity and effectiveness of a symptomatic approach based on symptoms, administered by a nurse working in women's health area, in identifying vaginal infections in women with or without vaginal discharge. | 2009 | 19284438 |
| comparative analyses among the trichomonas vaginalis, trichomonas tenax, and tritrichomonas foetus 5s ribosomal rna genes. | the 5s ribosomal rna (5s rrna) is an essential component of ribosomes. throughout evolution, variation is found among 5s rrna genes regarding their chromosomal localization, copy number, and intergenic regions. in this report, we describe and compare the gene sequences, motifs, genomic copy number, and chromosomal localization of the trichomonas vaginalis, trichomonas tenax, and tritrichomonas foetus 5s rrna genes. t. vaginalis and t. foetus have a single type of 5s rrna-coding region, whereas t ... | 2009 | 19290527 |
| genetic identity and differential gene expression between trichomonas vaginalis and trichomonas tenax. | trichomonas vaginalis is a human urogenital pathogen responsible for trichomonosis, the number-one, non-viral sexually transmitted disease (std) worldwide, while t. tenax is a commensal of the human oral cavity, found particularly in patients with poor oral hygiene and advanced periodontal disease. the extent of genetic identity between t. vaginalis and its oral commensal counterpart is unknown. | 2009 | 19296850 |
| prospective study of correlates of vaginal lactobacillus colonisation among high-risk hiv-1 seronegative women. | vaginal colonisation with lactobacillus species is characteristic of normal vaginal ecology. the absence of vaginal lactobacilli, particularly hydrogen peroxide (h(2)o(2))-producing isolates, has been associated with symptomatic bacterial vaginosis (bv) and increased risk for hiv-1 acquisition. identification of factors associated with vaginal lactobacillus colonisation may suggest interventions to improve vaginal health. | 2009 | 19329442 |
| sexually transmitted infections and reproductive tract infections in female sex workers. | the present study was conducted in 300 female sex workers (fsws) from surat city in 2005-2006. vaginal swabs, endocervical swabs and serum samples were collected from each of these fsws. vaginal samples were screened for bacterial vaginosis (bv), candidiasis and trichomonas vaginalis . endocervical swabs were screened for gonococcal infection. serological tests for human immunodeficiency virus (hiv), hepatitis b surface antigen (hbsag) and syphilis were performed. from a total of 300 fsws, bv wa ... | 2009 | 19332911 |
| the microaerophilic flagellate, trichomonas vaginalis, contains unusual acyl lipids but no detectable cardiolipin. | previous lipid analysis of trichomonads has led to controversy as to whether these hydrogenosome-containing organisms contain cardiolipin (cl), which is a characteristic component of mitochondria. here we report a careful lipid analysis of the sexually transmitted protist trichomonas vaginalis. major lipids were phosphatidylethanolamine (42%) and phosphatidylcholine (20%) with lesser amounts of phosphatidylglycerol (pg) (12%) and non-polar components. two unusual lipids, acyl-pg (8%) and ceramid ... | 2009 | 19335774 |
| clinical significance of trichomonas vaginalis detected in papanicolaou smear: a survey in female social hygiene clinic. | to evaluate the clinical significance of trichomonas vaginalis detected in papanicolaou (pap) smears in our local population. | 2009 | 19342733 |
| association between group a beta-haemolytic streptococci and vulvovaginitis in adult women: a case-control study. | guidelines for the management of vaginal discharge mention candida albicans, trichomonas vaginalis, bacterial vaginosis, chlamydia trachomatis and neisseria gonorrhoeae as causes and do not recommend full microbiological culture. the role of non-group b beta-haemolytic streptococci in vaginal cultures is unclear, except for group a streptococci that are known to cause vulvovaginitis in children. in a case-control study, we investigated the association between non-group b beta-haemolytic streptoc ... | 2009 | 19343383 |
| simultaneous identification of 14 genital microorganisms in urine by use of a multiplex pcr-based reverse line blot assay. | the aim of this study was to develop and evaluate a sensitive method for the simultaneous identification of 14 urogenital potential pathogens. a multiplex pcr-based reverse line blot (mpcr/rlb) assay was developed to detect 14 urogenital pathogens or putative pathogens, namely trichomonas vaginalis, streptococcus pneumoniae, neisseria gonorrhoeae, chlamydia trachomatis, ureaplasma parvum, u. urealyticum, gardnerella vaginalis, haemophilus influenzae, herpes simplex virus type 1 (hsv1) and hsv2, ... | 2009 | 19357202 |
| glyceraldehyde-3-phosphate dehydrogenase is a surface-associated, fibronectin-binding protein of trichomonas vaginalis. | trichomonas vaginalis colonizes the urogenital tract of humans and causes trichomonosis, the most prevalent nonviral sexually transmitted disease. we have shown an association of t. vaginalis with basement membrane extracellular matrix components, a property which we hypothesize is important for colonization and persistence. in this study, we identify a fibronectin (fn)-binding protein of t. vaginalis. a monoclonal antibody (mab) from a library of hybridomas that inhibited the binding of t. vagi ... | 2009 | 19380472 |
| mycoplasma genitalium compared to chlamydia, gonorrhoea and trichomonas as an aetiological agent of urethritis in men attending std clinics. | to investigate prevalence of mycoplasma genitalium, chlamydia trachomatis, neisseria gonorrhoeae and trichomonas vaginalis in men, frequency of co-infections, and association of organisms with urethritis in men. | 2009 | 19383597 |
| high rates of std and sexual risk behaviors among garífunas in honduras. | honduras has the highest concentration of hiv and aids cases in central america, with an estimated adult hiv prevalence of 1.5%. prevalence is higher among certain ethnic groups such as the garífuna with a reported hiv prevalence of 8%. | 2009 | 19384098 |
| three-dimensional structure of the cytoskeleton in trichomonas vaginalis revealed new features. | the flagellated protozoan trichomonas vaginalis has been widely studied owing to its medical significance and unique structure. the complicated three-dimensional (3d) structure of the cellular components of t. vaginalis was reconstructed from serial sections to enable observation of the spatial features of the whole cell. electron tomography was used to examine the detailed structure of the cellular organelles. tomographic reconstruction showed the mastigont system and the parabasal filament of ... | 2009 | 19386993 |
| simple and inexpensive point-of-care tests improve diagnosis of vaginal infections in resource constrained settings. | bacterial vaginosis (bv) and trichomonas vaginalis infection (tv) have been associated with adverse birth outcomes and increased risk for hiv. we compare the performance of simple inexpensive point-of-care (poc) tests to laboratory diagnosis and syndromic management of bv and tv in poor settings. | 2009 | 19392745 |
| alfred francois donné (1801-78): a pioneer of microscopy, microbiology and haematology. | alfred françois donné is widely known in the scientific community as the discoverer of trichomonas vaginalis, since he was the first to illustrate the parasite that later was recognized to cause vaginal infections. however, his other, less-known findings are equally important: he was also the inventor of the photoelectric microscope, with the assistance of his student léon foucault, as well as the first to apply photography to microscopic preparations (daguerreotype). his research in microscopy ... | 2009 | 19401511 |
| characteristics of hiv-1 discordant couples enrolled in a trial of hsv-2 suppression to reduce hiv-1 transmission: the partners study. | the partners hsv-2/hiv-1 transmission study (partners study) is a phase iii, placebo-controlled trial of daily acyclovir for genital herpes (hsv-2) suppression among hiv-1/hsv-2 co-infected persons to reduce hiv-1 transmission to their hiv-1 susceptible partners, which requires recruitment of hiv-1 serodiscordant heterosexual couples. we describe the baseline characteristics of this cohort. | 2009 | 19404392 |
| use of a dual priming oligonucleotide system to detect multiple sexually transmitted pathogens in clinical specimens. | to evaluate a new dual priming oligonucleotide (dpo)-based multiplex polymerase chain reaction (pcr) assay for detection of six sexually transmitted pathogens, including chlamydia trachomatis, neisseria gonorrhoeae, mycoplasma genitalium, mycoplasma hominis, ureaplasma urealyticum and trichomonas vaginalis. | 2009 | 19413770 |
| trichomonas vaginalis: metronidazole and other nitroimidazole drugs are reduced by the flavin enzyme thioredoxin reductase and disrupt the cellular redox system. implications for nitroimidazole toxicity and resistance. | infections with the microaerophilic parasite trichomonas vaginalis are treated with the 5-nitroimidazole drug metronidazole, which is also in use against entamoeba histolytica, giardia intestinalis and microaerophilic/anaerobic bacteria. here we report that in t. vaginalis the flavin enzyme thioredoxin reductase displays nitroreductase activity with nitroimidazoles, including metronidazole, and with the nitrofuran drug furazolidone. reactive metabolites of metronidazole and other nitroimidazoles ... | 2009 | 19415801 |
| the hydrogenosomes of psalteriomonas lanterna. | hydrogenosomes are organelles that produce molecular hydrogen and atp. the broad phylogenetic distribution of their hosts suggests that the hydrogenosomes of these organisms evolved several times independently from the mitochondria of aerobic progenitors. morphology and 18s rrna phylogeny suggest that the microaerophilic amoeboflagellate psalteriomonas lanterna, which possesses hydrogenosomes and elusive "modified mitochondria", belongs to the heterolobosea, a taxon that consists predominantly o ... | 2009 | 20003182 |
| time from first intercourse to first sexually transmitted infection diagnosis among adolescent women. | to determine the time between first intercourse and first sexually transmitted infection (sti) with chlamydia trachomatis, neisseria gonorrhoeae, or trichomonas vaginalis and time between repeated infections. | 2009 | 19996047 |
| urinary tract infection among asymptomatic hiv patients in benin city, nigeria. | the impact of human immunodeficiency virus (hiv) infection and cd4+ count on the prevalence of urinary tract infection (uti) is studied to determine the prevalence of uti among hiv and non-hiv subjects. clean-catch midstream urine and venous blood was collected from 421 subjects comprising 317 hiv patients (89 men, 228 women) and 104 non-hiv subjects (48 men, 56 women). the hiv patients consisted of 101 highly active antiretroviral therapy (haart)-naive subjects and 216 patients on haart for thr ... | 2009 | 20095127 |
| [microbiological diagnosis of sexually transmitted infections (sti): part 1. non-viral sti]. | non-viral sexually transmitted infections (sti) are an important cause of physical, psychological and social distress, have severe consequences for women's reproductive health and may be transmitted to the newborn child. these infections are also risk factors for the acquisition and transmission of hiv and other sti, and for premature labor. in the last years we have observed a gradual decrease in the national incidence of gonorrhea. the implementation of a screening program in our country for c ... | 2009 | 20098788 |
| in vitro activity of arbutus unedo leaf extracts against trichomonas vaginalis trophozoites. | trichomonas vaginalis (t. vaginalis) is a flagellated protozoan commonly causing sexually transmitted disease. t. vaginalis infections are treated with a 5-nitroimidazole derivate. however, drug resistance has been known to occur for a long time and new alternatives are under investigation. arbutus unedo is a wild plant mainly growing in maquis and rocky places of the seaboard in southern europe. in our study, ethanolic, water, hexane and ethyl acetate extracts of arbutus unedo leaves were teste ... | 2009 | 20101573 |
| [the relation between trichomoniasis and contraceptive methods]. | trichomoniasis is a sexually transmitted disease caused by trichomonas vaginalis (t. vaginalis) infecting the urogenital system. in this study, the relation between different contraceptive methods used and t. vaginalis infection was investigated. a total of 253 women (aged from 20-48 years) with abnormal vaginal discharges who applied to the obstetrics and gynecology outpatient clinic were enrolled in the study. t. vaginalis was diagnosed by microscopic examination of direct and giemsa stained p ... | 2009 | 20101574 |
| high throughput genome-wide survey of small rnas from the parasitic protists giardia intestinalis and trichomonas vaginalis. | rna interference (rnai) is a set of mechanisms which regulate gene expression in eukaryotes. key elements of rnai are small sense and antisense rnas from 19 to 26 nt generated from double-stranded rnas. micrornas (mirnas) are a major type of rnai-associated small rnas and are found in most eukaryotes studied to date. to investigate whether small rnas associated with rnai appear to be present in all eukaryotic lineages, and therefore present in the ancestral eukaryote, we studied two deep-branchi ... | 2009 | 20333187 |
| evaluation of common organisms causing vaginal discharge. | vaginal discharge is very common problem among females. alteration in balance of normal vaginal organisms can cause the overgrowth of the bacteria that creates vaginal discharge. it is common among sexually active women yet there still remain gaps in our knowledge of this infectious disorder. | 2009 | 20524479 |
| a clinicopathological study of urethritis in males. | to determine the etiology and frequency of different types of urethritis in adult males. | 2009 | 20042155 |
| [cloning, expression and immunogenicity analysis of cysteine proteinase 3 of trichomonas vaginalis]. | to study the humoral antibody response of mice to the recombinant trichomonas vaginalis cysteine proteinase (tvcp3) in order to investigate the function of the proteinase and its application in diagnosis. | 2009 | 20232629 |
| current and future perspectives on the chemotherapy of the parasitic protozoa trichomonas vaginalis and entamoeba histolytica. | trichomonas vaginalis and entamoeba histolytica are clinically important protozoa that affect humans. t. vaginalis produces sexually transmitted infections and e. histolytica is the causative agent of amebic dysentery. metronidazole, a compound first used to treat t. vaginalis in 1959, is still the main drug used worldwide to treat these pathogens. it is essential to find new biochemical differences in these organisms that could be exploited to develop new antiprotozoal chemotherapeutics. recent ... | 2009 | 21426030 |
| [in vitro anti-trichomonas vaginalis effects of a mixture of dihydroartemisinin and metronidazole]. | to observe the effect of a mixture of dihydroartemisinin and metronidazole on ultrastructure of trichomonas vaginalis trophozoites in vitro for exploring trichomonacidal mechanism of the drug mixture. | 2010 | 21500527 |
| [mge-pcr in analyzing the genetic characteristics and the clinical manifestation of trichomonas vaginalis isolates]. | to analyze the genetic characteristics of trichomonas vaginalis isolates causing different clinical manifestation. | 2010 | 21500530 |
| [procedure for trichomonas vaginalis cultivation]. | the investigation was undertaken to design a nutrient medium that could reduce the duration of a culture test in the diagnosis of trichomoniasis and to comparatively evaluate its effectiveness. a procedure was proposed to cultivate trichomonas vaginalis, which was based on the use of the nutrient medium containing casein hydrolysate, yeast autolysate, and serum, added by 0.6 ml of liquid ferrum lec (iron (iii) hydroxide polyisomaltose), which reduced the time taken to identify trichomonas vagina ... | 2010 | 21400718 |
| relationship between infectious agents for vulvovaginitis and skin color. | many factors influence occurrences of vulvovaginitis. the aims here were to assess skin color and age-related differences in the vaginal flora and occurrences of vulvovaginitis. | 2010 | 21308158 |
| [cryopreservation of trichomonas vaginalis and its influence factors]. | different concentrations of dimethylsulfoxide (dmso) and glycerol, various densities of trichomonas vaginalis trophozoites and duration of storage were used to study the effects on the cryopreservation of t. vaginalis at -78 degrees c. the optimal densities of trichomonads for cryopreservation were (1-2) x10(6)/ml. glycerol and dmso showed a high protective effect, with a maximum effect at a concentration of 10%, and the survival rates were 38.0% and 31.7%, respectively. there was no significant ... | 2010 | 21351558 |