Publications

[pulp reaction to the action of iatrogenic factors. ii. assessment of the action of chemical agents used in the treatment of deep dental caries].		1977	271059
the salivary concentration of streptococci mutans and streptococci sanguis and their colonization of artificial tooth fissures in man.		1977	271488
recreational drug use among auckland high school students.	the first large scale questionnaire survey of auckland high school students demonstrated widespread use of alcohol, a slight drop in tobacco use relative to an earlier survey and almost one-third of the students prepared to take marihuana if the opportunity arose. the reasons given by the students for their regular use or abstention from various drugs are discussed in the context of pervasive drug use throughout new zealand society and the drug information currently available to high school stud ...	1977	271814
the relationship between the surface area of the enamel crowns of human teeth and that of the dentine-enamel junction.		1977	272140
bacterial meningitis in children.	cases of bacterial, non-tuberculous meningitis among auckland children aged one month to 13 years were reviewed for the five year period september 1971 to september 1976. the aetiological agent was established in 203 of 227 cases. haemophilus influenzae was the most frequent cause and together with streptococcus pneumoniae accounted for all sequelae s. pneumoniae was responsible for most fatal cases. it is an unusually common cause of meningitis in auckland, particularly in children under a year ...	1977	272567
[double skin cancer coexisting with chronic myeloid leukemia].	in a 71-year-old man chronic myeloid leukaemia was diagnosed 4--5 years after cure of pulmonary tuberculosis and removed auricular cancer and 2 years after nasal cancer cured by means of local radiotherapy.	1977	272812
experimental caries in young human permanent teeth implanted in removable dentures.		1977	272867
inhibition of transformation and transfection in haemophilus influenzae rd9 by lysogeny.	haemophilus influenzae rd9 lysogenic for temperate bacteriophage n3 was found to be virtually nontransformable and nontransfectable. this inhibition of transformation and transfection was due partly to the decreased capacity of competent lysogenic cells for irreversible binding of deoxyribonucleic acid (dna) and partly to some events taking place after adsorption of the dna. the unadsorbed dna was not degraded by the competent lysogenic cells.	1977	299746
acute epididymoorchitis as the presenting manifestation of hemophilus influenzae septicemia.		1977	299771
hemophilus influenzae type b infections: recurrent disease due to ampicillin-resistant strains.		1977	299773
ampicillin-resistant h. influenzae subdural empyemia following successful treatment of apparently ampicillin-sensitive h. influenzae meningitis.		1977	299774
rapid ampicillin susceptibility testing for haemophilus influenzae.	recent isolations of strains of haemophilus influenzae resistant to ampicillin necessitate the development of a rapid, dependable, reproducible method of determining their antibiotic susceptibility. an agar-dilution method permitting susceptibility determinations on clinical specimens within 6-18 hours of specimen collection was designed. chocolate agar biplates were made with one side having no additive and the other containing 2 mug/ml ampicillin. seventy clinical specimens (cerebrospinal flui ...	1977	299794
bilateral cellulitis of cheeks in an infant due to hemophilus influenzae.		1977	299834
fosfomycin treatment of haemophilus influenzae infection in mice.	haemophilus influenzae is an important pathogen in respiratory infections in children and often is implicated in otitis media. it is sensitive in vitro to a number of antibiotics, some of which are used clinically for the treatment of such infections. we have checked the in vitro sensitivity of a type b strain of h. influenzae. when tested in levinthal's broth prepared with laked rabbit blood, the culture was most sensitive to tetracycline, ampicillin and penicillin and was somewhat less sensiti ...	1977	299838
the role of encapsulation and host age in the clearance of haemophilus influenzae bacteremia.	nonimmune rats given intravenous inoculations of 10(8) encapsulated haemophilus influenzae type b cleared the bacteria at an exponential rate for 10 min; thereafter, the bacteremia plateaued at approximately 10(6) organisms/ml of blood. with 10(8) unencapsulated organisms, the initial clearance rate was significantly faster (p less than 0.001) and was complete by 30 min. the rate of clearance of a mutant strain of h. influenzae type b containing 0.1% as much capsular polysaccharide as the wild t ...	1977	299866
hypopyon and orbital cellulitis associated with haemophilus influenzae type b meningitis. diagnostic and therapeutic implications.	three children, 8 months to 2 years of age, demonstrated unusual manifestations in association with haemophilus influenzae septicemia and meningitis. after one child had been diagnosed as having orbital cellulitis in conjunction with h influenzae meningitis, a second child, with orbital cellulitis and no clinical evidence of meningitis, had a lumbar tap indicative of a meningitis. a third child developed a hypopyon in association with h influenzae meningitis and septic arthritis of several joint ...	1977	299978
rapid method for determining the minimum inhibitory concentration of ampicillin for haemophilus influenzae.	a rapid method for determining the minimal inhibition concentrations (mics) of ampicillin using haemophilus influenzae as the test organism is described. this semiautomated technique using the autobac system was compared with the agar dilution mic method. fifty-seven isolates of both susceptible and resistant h. influenzae were tested. there was exact quantitative agreement with 65% of the isolates, and 91% of the isolates showed no more than a one-dilution-interval difference when mics were det ...	1977	299999
[pleuropulmonary lesions due to haemophilus influenzae].	empyema due to hemophilus influenzae has been reported only rarely. this report describes the cases of ten children with empyema due to this organism. diagnosis was made through growth of the organism in pure culture from pleural effusion. h. influenzae empyema may occur in older children as well as in infants and, in contrast to certain other infections with this organism, empyema due to h. influenzae may be more common than is generally suspected.	1977	300024
cefamandole and ampicillin therapy in experimental haemophilus influenzae meningitis.	cefamandole and ampicillin were compared in the therapy of experimental haemophilus influenzae meningitis in rabbits. three dosages of each drug were administered as a continuous intravenous infusion for 8 hr to 24 infected animals. samples of serum and cerebrospinal fluid (csf) were obtained at 0, 4, and 8 hr for determination of antibiotic concentrations and bacterial titers in csf. serum levels of cefamandole were higher, but csf concentrations of both antibiotics were similar. with the 60-mg ...	1977	300093
haemophilus influenzae meningitis in infant rats: role of bacteremia in pathogenesis of age-dependent inflammatory responses in cerebrospinal fluid.	abnormalities in cerebrospinal fluid associated with meningitis due to haemophilus influenzae type b were characterized in infant rats. after intranasal inoculation of bacteria, the development of intense bacteremia (greater than 10(4) colony-forming units/ml) correlated with cultures of cerebrospinal fluid positive for h. influenzae, with pleocytosis, and with hisotologic evidence of meningitis. the degree of pleocytosis was related to the age of the animal, the amount of time since inoculation ...	1977	300094
a comparison of chloramphenicol and ampicillin as bactericidal agents for haemophilus influenzae type b.	in tests of bactericidal action against h. influenzae type b strains isolated from patients with meningitis, chloramphenicol was found to be far more reliable than ampicillin in dealing with large inocula, and more rapidly effective against both large and relatively small inocula. these findings provide a laboratory explanation for the somewhat better record of chloramphenicol as an agent for treatment of haemophilus meningitis.	1977	300110
reevaluation of neonatal hemophilus influenzae infections.	hemophilus influenzae infections are increasing in frequency in the general population. as a result this organism must be considered an etiologic agent of disease in the neonate. proper culture technics must be routinely employed to isolate this fastidious organism, and appropriate antimicrobial therapy must be instituted in infants suspected of having sepsis or meningitis. three cases of h influenzae infection occurring in neonates are presented.	1977	300177
hla and hemophilus influenzae disease.		1977	300191
standardized disk-diffusion susceptibility test for haemophilus influenzae.	the emergence of ampicillin-resistant strains of haemophilus influenzae has emphasized the need for an improved practical method for routine susceptibility testing of clinical isolates. we have previously described a simplified medium for quantitative dilution susceptibility testing that is composed of mueller-hinton medium plus supplement c (difco). in the present study, paired broth-dilution and disk-diffusion susceptibility tests with ampicillin and chloramphenicol were performed on 100 strai ...	1977	300221
formation of a thymine photoproduct in transforming dna by near ultraviolet irradiation.	irradiation at 334 and 365 nm of a highly purified preparation of thymine-labeled transforming dna from haemophilus influenzae produced a photo product containing label from thymine but different from the cyclobutane dimer. the photoproduct is soluble in water and in ethanol and rf values in a number of solvents are presented. the photoproduct has properties similar in a number of respects to those of the spore photoproduct, 5-thyminyl-5,6-dihydrothymine. the near ultraviolet photoproduct is mor ...	1977	300251
immunoprotective activity of ribosomes from haemophilus influenzae.	immunization with ribosomal preparations from haemophilus influenzae type b elicited protective immunity in mice. ribosomes from disrupted cells where isolated by differential centrifugation using sodium dodecyl sulfate. the washed ribosomes contained 25% protein and 75% ribonucleic acid and sedimented as a single peak on sucrose density gradient analysis with a sedimentation coefficient of 67s, using escherichia coli ribosomes as a 70s marker. immunodiffusion tests with antipolyribose phosphate ...	1977	300360
isolation of the capsular polysaccharide from culture supernatant of haemophilus influenzae type b.	the capsular polysaccharide (cp) of haemophilus influenzae type b is known to be spontaneously released from the cells in culture. the cp is precipitable from culture supernatant by the cationic detergent hexadecyltrimethylammonium. most of the nucleic acid and some of the protein, but almost none of the endotoxin, in the supernatant are co-precipitated. extraction of the precipitate with progressively stronger nacl solutions separates nucleic acid and protein from the cp and also effects a mole ...	1977	300361
[ampicillin resistant haemophilus influenzae. 3 documented cases in denmark].		1977	300517
[ampicillin resistant haemophilus influenzae].		1977	300518
interaction of rna polymerase with promoters from bacteriophage fd.	replicative form dna of bacteriophage fd, which had been fragmented with the restriction endonuclease ii from hemophilus parainfluenzae (endo r- hpaii), was reacted with escherichia coli rna polymerase; the resulting stable preinitiation complexes were analysed using the filter binding assay followed by gel electrophoresis. at 120mm kcl the first-order rate constants for complex decay were determined to be 10(-2)-10(-6)s-1. the second-order rate constants for complex formation were found to be a ...	1977	300680
neonatal haemophilus aphrophilus meningitis.	case report of a neonatal meningitis due to haemophilus influenzae. the treatment with ampicillin was ineffective because of insensitivity. this case demonstrates the importance of a proper bacteriological identification in order to avoid ineffective or delayed treatment.	1977	300734
potentiation of experimental meningitis due to haemophilus influenzae by influenza a virus.	when haemophilus influenzae type b was given intranasally to infant rats, a very large dose was required to produce histologic evidence of meningitis in even half of the animals tested; meningitis developed in 16 of 31 rats that received 10(7) viable bacteria at the age of five days. however, when the animals first received influenza virus, the dose of bacteria required to produce meningitis was reduced 100-fold; meningitis occurred in 10 of 21 rats given virus at two days and 10(5) viable bacte ...	1977	300760
chloramphenicol-resistant hemophilus influenzae.		1977	300793
effects of x irradiation on a temperate bacteriophage of haemophilus influenzae.	the inactivation of bacteriophage hp1c1 by x rays in a complex medium was found to be exponential, with a d0 (the x-ray exposure necessary to reduce the survival of the phage to 37%) of approximately 90 kr. analysis of results of sucrose sedimentation of dna from x-irradiated whole phage showed that the d0 for intactness of single strands was about 105kr, and for intactness of double strands, it was much higher. the d0 for attachment of x-irradiated phage to the host was roughly estimated as abo ...	1977	300811
[haemophilus influenzae meningitis in childhood].		1977	300862
[septic arthritis and ataxia as complications of haemophilus influenzae meningitis].		1977	300932
antibacterial activity of netilmicin, a new aminoglycoside antibiotic, compared with that of gentamicin.	the antibacterial activity of netilmicin (sch 20569), a new semisynthetic aminoglycoside, was compared with that of gentamicin against a variety of gram-negative bacteria, staphylococci, and streptococci. both antibiotics had similar activity against most organisms, but netilmicin had appreciably greater activity against gram-negative organisms that were resistant to gentamicin because these species synthesized aminoglycoside 3-n-acetyltransferase i or aminoglycoside 2''-o-nucleotidyltransferase ...	1977	301004
comparison of in vitro activity of cephalexin, cephradine, and cefaclor.	inhibitory activity of cephalexin, cephradine, and cefaclor was compared by the who-ics agar dilution technique. cefaclor was substantially more active against staphylococci, streptococci, gonococci, meningococci, haemophilus, escherichia coli, klebsiella pneumoniae, citrobacter diversus, proteus mirabilis, salmonellae, and shigellae than was cephalexin, which in turn was more active than cephradine. cefaclor appeared to be less resistant to staphylococcal penicillinase than did the other two ag ...	1977	301005
ampicillin-induced morphological alterations of haemophilus influenzae type b.	inhibitory levels of ampicillin induced filamentation of growing haemophilus influenzae atcc 19418 within 30 min. filaments became swollen and interrupted by regular periodic saccular outpouchings along the major axis. the degree of filamentation was dependent upon ampicillin concentration and time.	1977	301006
comparative acitivity of ampicillin and cefuroxime against three types of haemophilus influenzae.	on the basis of their susceptibility to ampicillin, strains of haemophilus influenzae can be divided into three types: type 1 are normally susceptible strains, type 2 produce stable spheroplasts from low inocula, and type 3 are beta-lactamase producers. because of the production of spheroplasts, standard broth and agar dilution techniques have failed to differentiate between the responses of type 2 and 3 strains to ampicillin, or to identify the superiority of cefuroxime over ampicillin against ...	1977	301007
bactericidal factor produced by haemophilus influenzae b: partial purification of the factor and transfer of its genetic determinant.	when aerobically grown on complex media, haemophilus influenzae b and unencapsulated variants, rb strains, produced a bactericidal factor that was active against other haemophilus species and certain genera of the enterobacteriaceae. a total of 341 clinical isolates of haemophilus were tested for susceptibility to the factor. ninety-three percent of h. influenzae (nontypable), 75% of h. haemolyticus, 71% of h. parainfluenzae, and 22% of h. parahaemolyticus were susceptible. h. influenaze b strai ...	1977	301008
[severe infections by haemophilus influenzae in children].	severity and increasing incidence of serious infections due to haemophilus influenzae in children have been stressed in recent publications. an analysis of the clinical records of the department of pediatrics, hospital roberto del río (santiago, chile) was made in order to gather information about frequency and clinical feature of this kind of infections in our environement. 120 children under 3 years of age in whom h. influenzae was isolated in samples of one or more of the following sources: c ...	1977	301394
[effect of spa treatment in luhacovice on the bacterial colonization of the upper respiratory tract mucosa].		1977	301499
immunology of the infant rat experimental model of haemophilus influenzae type b meningitis.	the age-related acquisition of serum anticapsular and bactericidal antibodies to haemophilus influenzae type b observed in rats was similar to that of humans. the antigenic source for this "natural" immunity was not identified since neither pharyngeal infection with h. influenzae b nor enteric colonization by cross-reacting bacteria was detected. infant rats surviving h. influenzae b bacteremia failed to respond immunologically to the capsular polysaccharide. however, surviving rats demonstrated ...	1977	301506
activation of the alternative complement pathway by haemophilus influenzae type b.	the results of the following study demonstrate that haemophilus influenzae type b (hitb) is able to activate the alternative complement pathway. they also demonstrate that the activation of the alternative pathway by hitb is not mediated by the capsule.	1977	301507
relationships among some r plasmids found in haemophilus influenzae.	tetracycline resistance in a strain of haemophilus influenzae isolated in the united kingdom was found to be determined by an apparently non-selftransmissible plasmid of 31 x 10(6) daltons (31 mdal), designated pub701. deoxyribonucleic acid hybridization studies indicated that pub701 shares about 70% base sequence homology with the 30-mdal ampicillin resistance r plasmid rsf007 isolated in the united states from h. influenzae, and 64% sequence homology with the 38-mdal tetracycline and chloramph ...	1977	301523
detection of beta lactamase activity of haemophilus influenzae.		1977	301528
haemophilus influenzae pneumonia in adults.	thirty cases of haemophilus influenzae pneumonia with clinical and laboratory features have previously been recorded in adults. during the past three years, we have examined 18 patients in whom this diagnosis was established by transtracheal aspirate or blood culture. our study suggests that h influenzae, both typable and nontypable strains, is a more frequent cause of pneumonia in adults than previously appreciated. we found no clinical values that distinguished h influenzae pneumonia from othe ...	1977	301574
impaired humoral immunity in treated hodgkin's disease.	to define the contribution of aggressive lymphoma treatment to the risk of post-splenectomy septicemia, we investigated the humoral immunity of 44 patients with hodgkin's disease. specific antibody against haemophilus influenzae type b was significantly reduced (mean, 147 ng per milliliter, p less than 0.01) in patients receiving combined treatment (radiotherapy and chemotherapy), whereas single treatment reduced titers marginally (chemotherapy) or not at all (radiotherapy). untreated patients h ...	1977	301608
intrafamily spread of haemophilus type b infections.	meningitis and epiglottitis are the clinical manifestations of severe haemophilus influenzae serotype b infection. compared with meningitis, epiglottitis occurs in older children. when secondary cases occur within the family, the type of clinical manifestation produced by this serotype is generally similar in siblings. this report concerns the unusual occurrence of meningitis developing in older child and epiglottitis developing in the younger one. we discuss the possible explanations for this u ...	1977	301699
ampicillin-resistant haemophilus influenzae meningitis following an ampicillin-sensitive bacteremia in an infant.		1977	301700
manner and meaning of susceptibility testing of ampicillin-resistant haemophilus influenzae.	we examined ampicillin-resistant strains of haemophilus influenzae to compare the percentage of resistant organisms in each strain with the susceptibility to ampicillin by an agar dilution method. using an inoculum of 10(4) colony-forming units, the minimal inhibitory concentration (mic) increased with the percentage of resistant organisms in the strain. laboratory-manipulated strains composed of different proportions of a susceptible and a resistant strain behaved similarly. the survival of iso ...	1977	301728
the structure of the capsular antigen from haemophilus influenzae type a.	structural investigation of the capsular antigen from haemophilus influenzae type a has shown it to be composed of 4-o-beta-d-glucopyranosyl-d-ribitol residues joined through phosphoric diester linkages between o-4 of d-glucose and o-5 of d-ribitol. chemical degradations and 13c-n.m.r. spectroscopy were the main methods used.	1977	301786
haemophilus influenzae type b disease. incidence in a day-care center.	haemophilus influenzae type b (hib) disease was observed during a 14-month period in seven of 48 infants attending a day-care center. surveillance studies showed that 28 (58%) infants had positive nasopharyngeal cultures for hib; four infants were colonized with hib for nine to 12 months. ampicillin trihydrate prophylaxis failed to reduce the hib carrier rate. haemophilus influenzae type b polysaccharide vaccine was administered to 34 of the children. sera obtained prior to immunization showed d ...	1977	301947
occlusion of the internal carotid artery complicating haemophilus influenzae meningitis.	we report a patient with occlusion of the internal carotid artery complicating haemophilus influenzae meningitis. the etiology of this complication is discussed, along with its role in the acute seizures of meningitis, and in the chronic neurological residua of this infection.	1977	302088
cervical lymphadenitis caused by haemophilus influenzae type b.		1977	302089
pneumonia due to haemophilus influenzae (h. aegyptius) biotype 3.	haemophilus influenzae (h. aegyptius) biotype 3 was isolated from eye, nasopharyngeal, and sputum cultures of a 23-month-old male and from sputum and transtracheal aspirate cultures of his 39-year-old mother, both with diffuse bronchopneumonia.	1977	302264
pharyngeal colonization with haemophilus influenzae type b: a longitudinal study of families with a child with meningitis or epiglottitis due to h. influenzae type b.	a longitudinal study of pharyngeal colonization with haemophilus influenzae type b included 264 members of families that had a child with meningitis or epiglottitis due to this organism. it was found that (1) 52 of 67 such families contained at least one carrier of h. influenzae type b, who was usually a sibling; (2) h. influenzae type b spread slowly in 39 families colonized continuously during a six-month period, with only eight of 19 uncolonized siblings acquiring the organism during that tim ...	1977	302288
circulating capsular antigen in infant rats infected with haemophilus influenzae type b.	the kinetics of bacteremia and capsular antigenemia in infant rats infected with haemophilus influenzae type b were measured by quantitative bacterial counts in blood and counterimmunoelectrophoresis of plasma. after intraperitoneal inoculation with 10(4) colony-forming units (cfu) of h. influenzae type b, bacteremia was detected in 100% of animals at 12 hr after inoculation (mean, 16,500 cfu/ml) and by two days exceeded 10(5) cfu/ml in most animals. despite these high levels of bacteremia, caps ...	1977	302289
antibody of polyribophate of haemophilus influenzae type b in infants and children: effect of immunization with polyribophosphate.	antibody to polyribophosphate, the capsular polysaccharide of haemophilus influenzae type b, was measured in healthy ambulatory children by a radioactive antigen-binding assay. titers fell from birth through nine months of age, then increased until six years, when they plateaued. antibody activity was not correlated with the child's sex, ethnic status, or area of residence. doses of 0.2-50 microgram of polyribophosphate given as single or booster doses had similar effects on antibody activity. o ...	1977	302291
immunogenicity in weanling rabbits of a polyribophosphate complex from haemophilus influenzae type b.	polyribophosphate (prp), the capsular polysaccharide of haemophilus influenzae type b, is more effectively immunogenic when it is associated with the bacterium than when it is in the purified form that is being tested as a vaccine for humans. in an effort to analyze this difference, we isolated from h. influenzae type b a high-molecular-weight, soluble complex, in which prp appears to be combined with protein (about 7% protein). the pyrogenicity and limulus lysate gelation activity of the comple ...	1977	302292
cortical blindness following meningitis due to hemophilus influenzae type b.		1977	302325
ampicillin-resistant haemophilus in western australia.		1977	302389
evidence that uv-inducible error-prone repair is absent in haemophilus influenzae rd, with a discussion of the relation to error-prone repair of alkylating-agent damage.	haemophilus influenzae rd and its derivatives are mutated either not at all or to only a very small extent by ultraviolet (uv) radiation, x-rays, methyl methanesulfonate, and nitrogen mustard, though they are readily mutated by such agents as n-methyl-n'-nitro-n-nitrosoguanidine, ethyl methanesulfonate, and nitrosocarbaryl. in these respects h. influenzae rd resembles the lexa mutants of escherichia coli that lack the sos or reclex uv-inducible error-prone repair system. this similarity is furth ...	1977	302410
attempts to induce mutations in haemophilus influenzae with the base analogues 5-bromodeoxyuridine and 2-aminopurine.	attempts were made to induce mutations in haemophilus influenzae with the base analogues 5-bromodeoxyuridine and 2-aminopurine. these attempts were unsuccessful. incorporation studies with brdurd showed, in agreement with earlier studies on escherichia coli, that brdurd was discriminated against when dthd was also present but was incorporated to essentially the same extent as dthd when only brdurd was present. in this latter case, strands fully substituted with brdurd was produced, but survival ...	1977	302411
detection of a contaminant cell culture line by restriction endonuclease cleavage patterns of mitochondrial dna.	a putative hela cell culture line was discovered to be contaminated with mouse cells by examination of agarose gel profiles of restriction endonuclease digests of mitochondrial dna. the contamination was confirmed by karyotypic analysis, and by observation of the mouse satellite band in an analytical buoyant density centrifugation of total cellular dna. restriction endonuclease analysis of mitochondrial dna is suggested as a useful method for monitoring the species of cells in culture.	1977	302438
the quantitation of fluorescence by photography.	a method based on theory has been developed for the photographic quantitation of fluorescent substances. dna stained with ethidium in agarose gels is used as an example of an application of this method. in the course of developing this method we have demonstrated that the empirical methods employed by others authors can give rise to large systematic errors. we have also developed an approximate method based on photographic theory, avoiding the use of digital integration which is required by the ...	1977	302439
[role of haemophilus rods in cerebrospinal meningitis].		1977	302443
hemophilus endocarditis: new cases, literature review and recommendations for management.	rarely is endocarditis attributed to the species of hemophilus. most frequently implicated are h aphrophilus and h parainfluenzae, but h influenzae also is seen. we report six cases of endocarditis due to h aphrophilus or h parainfluenzae and review the literature. emboli to skin, lungs, kidneys, spleen, brain, and other organs are common complications, and acute glomerulonephritis and meningitis often occur. ampicillin is the mainstay of antimicrobial therapy for patients whose isolates are sen ...	1977	302487
evaluation of the capillary beta-lactamase test and antimicrobial susceptibility of haemophilus influenzae.	the capillary beta-lactamase test for the detection of haemophilus influenzae resistance to ampicillin was evaluated against 132 strains of h. influenzae recently isolated from clinical materials and four reference strains. nineteen strains, including two of serotype b, were beta-lactamase-positive. the minimal inhibitory concentrations (mic) of ampicillin for the 117 beta-lactamase-negative strains ranged from less than or equal to 0.125 to 2 microgram/ml (only one strain had a mic of 2 microgr ...	1977	302642
bacteremic hemophilus influenzae type b cellulitis in the adult.	described herein are three patients over the age of 50 years who had cellulitis of the neck and the upper portion of the chest, associated with hemophilus influenzae type b bacteremia and respiratory tract infection--particularly that of the upper airway. only one of the patients with cellulitis had the classic bluish-purple hue commonly seen in children affected with this syndrome. in the other two, the h. influenzae type b cellulitis could not be distinguished clinically from the more common g ...	1977	302644
acute purulent otitis media.		1977	302776
in vitro effects of lidocaine on anaerobic respiratory pathogens and strains of hemophilus influenzae.	lidocaine is commonly employed as a topical anesthetic agent during fiberoptic bronchoscopic procedures or transbronchial brushing. previous studies have demonstrated an inhibitory effect of lidocaine on the growth in culture media of gram-positive and gram-negative organisms, as well as several species of mycobacterium and various fungi. the current in vitro investigation demonstrates an inhibitory, as well as a bactericidal, effect of lidocaine hydrochloride (in concentrations identical to tho ...	1977	302778
hemophilus influenzae cellulitis following soft tissue injury.		1977	302853
acute epididymo-orchitis due to hemophilus influenzae type b.		1977	302854
hemophilus influenzae buccal cellulitis: five cases in eight weeks.		1977	302855
meningitis caused by hemophilus influenzae type e.		1977	302856
[cellulitis and bacteremia caused by haemophilus influenza group b].		1977	302886
[ampicillin resistance in haemophilus influenzae].		1977	302887
[ampicillin resistant haemophilus influenzae meningitis].		1977	302888
[bacteria and antibiotics in acute suppurative otitis media].		1977	302998
sputum fixatives.		1977	303032
[different types of cells in tissue cultures of normal bovine iris (author's transl)].	calf iris tissue cultured in tcm 199 was studied under the electron microscope at 5, 14, and 21 days. melanocytes and clump cells (macrophages), and mast cells could be distinguished, as well as fibroblasts, round cells, and non striated muscle cells, melanocytes lost their pigment granules temporarily, but not their ability to produce new ones again after a certain adaptation period. the morphology of clump and mast cells was only slightly altered. in incubation, fibroblasts and round cells wer ...	1977	303063
different behavioral responses to l-dopa after anterolateral or posterolateral hypothalamic injections of 6-hydroxydopamine.	after bilateral microinjections of 6-hydroxydopamine (6-ohda) into the anterolateral (al) or posterolateral (pl) hypothalamus l-dopa (1,3,4-dihydroxy-phenylalanine) produced running and rearing in al6-ohda rats and oral stereotypies in pl 6-ohda rats. since the same dose of l-dopa had no behavioral effect in vehicle injected rats, the responses to l-dopa of both al and pl 6-ohda rats are examples of behavioral supersensitivity. the different forms of behavioral supersensitivity correlated with d ...	1977	303138
synthesis of 1-o-beta-d-ribofuranosyl-d-ribitol.		1977	303146
course of the umbilical arteries in the human placenta.		1977	303199
haemophilus influenzae in otitis media and sinusitis: serotypes and susceptibilty to ampicillin and amoxycillin in vitro.	in order to obtain haemophilus influenzae, other than type b, with highly probable human pathogeniticy strains were collected that had been isolated in abundant numbers from middle ear or maxillary sinus secretions of 157 patients with otitis media or sinusitis. the distribution of serotypes was as follows: nontypable 33.8%, type b 26.1% type a 19.1%, type c 7.6%, type e 5.7%, type f 5.1%, and type d 2.5%. the type distribution did not depend on the source of the strains. all strains were suscep ...	1977	303234
cellulitis in children--a five year review.		1977	303347
[increasing importance of haemophilus influenzae in nose, ear and throat infections].	after the review of the morphology, the identification and the pathogenic properties of h. influenzae, its occurrence in the different ent infections is discussed. h. influenzae is found in chronic tonsillitis in 64% of the cases, in the deeper tissue of the tonsils, while its occurrence in the throat swabs is rare. in acute otitis media h. influenzae is present in 10 to 150% of the cases, while in rhinitis and sinusitis its increasing occurrence until 1974 is noted (28% of all sinusitis cases s ...	1977	303428
inherited immunodeficiency in chickens: a model for common variable hypogammaglobulinemia in man?		1977	303448
induction in b2/b2 chickens of immunity to transplantable carcinogen-induced fibrosarcomas mediated by t-cell monocyte cooperation: role of delayed hypersensitivity to unrelated antigens.		1977	303451
beta-lactamase effect on ampicillin treatment of haemophilus influenzae b bacteremia and meningitis in infant rats.	intraperitoneal injections of 250 mg of ampicillin per kg every 6 h for 30 h sterilized the blood and cerebrospinal fluid of infant rats infected with either a beta-lactamase-containing strain of haemophilus influenzae type b or a strain lacking the enzyme. however, a single injection of 100 mg/kg sterilized the blood and cerebrospinal fluid of significantly fewer of those rats infected with the beta-lactamase-producing strain. the results suggest that resistance of beta-lactamase-containing str ...	1977	303497
choice of antibiotics in management of acute osteomyelitis and acute septic arthritis in children.	a survey of 158 children with acute haematogenous osteomyelitis, and of 94 children with acute septic arthritis over an 8-year period was made to determine which bacteria cause these infections. in the osteomyelitis group the organism most frequently detected was staphylococcus aureus (74% of cases). in 16% of cases streptococci were found. staph. aureus was also the most frequently grown organism in cases of acute septic arthritis (55% of cases), but haemophilus influenzae accounted for 24% of ...	1977	303500
the treatment of chest infections.		1977	303513
heat sensitivity of haemophilus influenzae containing defective prophage.	strains of haemophilus influenzae that carry a defective prophage are more sensitive to heat than is a strain that does not, even in the presence of a rec-1 mutation, which normally renders prophage noninducible. the prophage of hp1c1, a nondefective phage, does not affect the heat sensitivity.	1977	303642
antibiotic therapy for severe infections in infants and children.	guidelines for the use of antibiotics in infants and children must take into account drug absorption, distribution, metabolism, and excretion. in the developing human being, these factors may differ significantly from those in the adult, and so there are differences in therapeutic efficacy and toxicity. certain drugs should be avoided in the neonate because of known toxicity; these include the sulfonamides, tetracycline, and high doses of chloramphenicol. antibiotic therapy should be modified in ...	1977	303730
pulmonary infections.		1977	303732
systemic haemophilus influenzae infections in the era of ampicillin resistance.		1977	303745
[the occurrence of neuraminidase and n-acetylneuraminate-pyruvate lyase in pathogenic haemophili of man (author's transl)].	we investigated the following six haemophilus species from man for the both enzymes neuraminidase and n-acetylneuraminate pyruvate lyase: h. aegypticus, h. aphrophilus, h. influenzae. h. parahaemolyticus, h. parainfluenzae and h. vaginalis. it is shown that h. vaginalis does not produce either neuraminidase or n-acetylneuraminate pyruvate lyase. he differs, therefore, from all other investigated haemophili producing both enzymes, neuraminidase and n-acetylneuraminate pyruvate lyase. colominic ac ...	1977	303852
countercurrent immunoelectrophoresis in the diagnosis of haemophilus influenzae type b infection: relationship of detection of capsular antigen to age, antibody response, and therapy.		1977	303865