Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| severe combined immunodeficiency (scid) and attention deficit hyperactivity disorder (adhd) associated with a coronin-1a mutation and a chromosome 16p11.2 deletion. | defects causing severe combined immunodeficiency (scid) have been reported in pathways mediating antigen receptor rearrangement, antigen receptor and cytokine signaling, and purine metabolism. recognizing that the actin regulator coronin-1a is essential for development of a normal peripheral t cell compartment in mouse models, we identified absence of coronin-1a in a girl with t-b+nk+ scid who suffered recurrent infections including severe post-vaccination varicella at age 13 months. murine coro ... | 2009 | 19097825 |
| mucosal immunization of mice with recombinant omp p2 induces antibodies that bind to surface epitopes of multiple strains of nontypeable haemophilus influenzae. | nontypeable haemophilus influenzae (nthi) is a significant cause of otitis media in children and exacerbations in patients with chronic obstructive pulmonary disease. vaccine research for nthi has focused on the outer membrane proteins (omps) of nthi. the goal of this study was to evaluate mucosal and systemic immune responses to recombinant omp p2 (rp2) of nthi. enzyme-linked immunosorbent assay (elisa) demonstrated that both mucosal and systemic routes of immunization resulted in antibodies to ... | 2009 | 19079335 |
| mucosal immunization of mice with recombinant omp p2 induces antibodies that bind to surface epitopes of multiple strains of nontypeable haemophilus influenzae. | nontypeable haemophilus influenzae (nthi) is a significant cause of otitis media in children and exacerbations in patients with chronic obstructive pulmonary disease. vaccine research for nthi has focused on the outer membrane proteins (omps) of nthi. the goal of this study was to evaluate mucosal and systemic immune responses to recombinant omp p2 (rp2) of nthi. enzyme-linked immunosorbent assay (elisa) demonstrated that both mucosal and systemic routes of immunization resulted in antibodies to ... | 2009 | 19079335 |
| novel biaryl oxazolidinones: in vitro and in vivo activities with pharmacokinetics in an animal model. | rbx 1000075 and rbx 1000276, the new investigational oxazolidinones, have an extended spectrum of in vitro activity against gram-positive pathogens and showed minimum inhibitory concentrations (mics) lower than comparator drugs. mic for 90% of the organisms (mic(90)) values of rbx 1000075, rbx 1000276 and linezolid against the isolates tested were, respectively: methicillin-sensitive staphylococcus aureus, 0.25, 1 and 4 microg/ml; methicillin-resistant s. aureus (mrsa), 0.5, 2 and 4 microg/ml; m ... | 2009 | 19091517 |
| current progress with moraxella catarrhalis antigens as vaccine candidates. | the success of the immunization programs against haemophilus influenzae type b and, more recently, streptococcus pneumoniae in developed and some developing countries has demonstrated that invasive disease caused by these bacteria can be very effectively controlled by vaccination. there is also evidence that pneumococcal vaccines can reduce the incidence of acute otitis media in children. more complete control of this disease would be achieved if infections caused by moraxella catarrhalis and no ... | 2009 | 19093775 |
| kinetic analysis of ligand interaction with the gonococcal transferrin-iron acquisition system. | the transferrin iron acquisition system of neisseria gonorrhoeae consists of two dissimilar transferrin binding proteins (tbp) a and b. tbpa is a tonb dependent transporter while tbpb is a lipoprotein that makes iron acquisition from transferrin (tf) more efficient. in an attempt to further define the individual roles of these receptors in the process of tf-iron acquisition, the kinetics of the receptor proteins in regards to ligand association and dissociation were evaluated. tf association wit ... | 2009 | 19048191 |
| kinetic analysis of ligand interaction with the gonococcal transferrin-iron acquisition system. | the transferrin iron acquisition system of neisseria gonorrhoeae consists of two dissimilar transferrin binding proteins (tbp) a and b. tbpa is a tonb dependent transporter while tbpb is a lipoprotein that makes iron acquisition from transferrin (tf) more efficient. in an attempt to further define the individual roles of these receptors in the process of tf-iron acquisition, the kinetics of the receptor proteins in regards to ligand association and dissociation were evaluated. tf association wit ... | 2009 | 19048191 |
| evaluation of an immunochromatographic assay kit for rapid identification of mycobacterium tuberculosis complex in clinical isolates. | we evaluated a new immunochromatographic assay (ica) using mouse monoclonal anti-mpt64 antibody for rapid discrimination between mycobacterium tuberculosis and nontuberculous mycobacteria in clinical isolates. a study with mycobacteria and other organisms showed excellent sensitivity (approximately equal 99%) and specificity (100%) and an appropriate detection limit (10(5) cfu/ml) when tested with m. tuberculosis h37rv. this ica can simplify the identification of m. tuberculosis in clinical labo ... | 2009 | 19052177 |
| evaluation of an immunochromatographic assay kit for rapid identification of mycobacterium tuberculosis complex in clinical isolates. | we evaluated a new immunochromatographic assay (ica) using mouse monoclonal anti-mpt64 antibody for rapid discrimination between mycobacterium tuberculosis and nontuberculous mycobacteria in clinical isolates. a study with mycobacteria and other organisms showed excellent sensitivity (approximately equal 99%) and specificity (100%) and an appropriate detection limit (10(5) cfu/ml) when tested with m. tuberculosis h37rv. this ica can simplify the identification of m. tuberculosis in clinical labo ... | 2009 | 19052177 |
| human decay-accelerating factor and ceacam receptor-mediated internalization and intracellular lifestyle of afa/dr diffusely adhering escherichia coli in epithelial cells. | we used transfected epithelial cho-b2 cells as a model to identify the mechanism mediating internalization of afa/dr diffusely adhering escherichia coli. we provide evidence that neither the alpha5 or beta1 integrin subunits nor alpha5beta1 integrin functioned as a receptor mediating the adhesion and/or internalization of dr or afa-iii fimbria-positive bacteria. we also demonstrated that (i) whether or not the afad or drad invasin subunits were present, there was no difference in the cell associ ... | 2009 | 19015254 |
| human decay-accelerating factor and ceacam receptor-mediated internalization and intracellular lifestyle of afa/dr diffusely adhering escherichia coli in epithelial cells. | we used transfected epithelial cho-b2 cells as a model to identify the mechanism mediating internalization of afa/dr diffusely adhering escherichia coli. we provide evidence that neither the alpha5 or beta1 integrin subunits nor alpha5beta1 integrin functioned as a receptor mediating the adhesion and/or internalization of dr or afa-iii fimbria-positive bacteria. we also demonstrated that (i) whether or not the afad or drad invasin subunits were present, there was no difference in the cell associ ... | 2009 | 19015254 |
| localization of the domains of the haemophilus ducreyi trimeric autotransporter dsra involved in serum resistance and binding to the extracellular matrix proteins fibronectin and vitronectin. | resisting the bactericidal activity of naturally occurring antibodies and complement of normal human serum is an important element in the evasion of innate immunity by bacteria. in the gram-negative mucosal pathogen haemophilus ducreyi, serum resistance is mediated primarily by the trimeric autotransporter dsra. dsra also functions as an adhesin for the extracellular matrix proteins fibronectin and vitronectin and mediates attachment of h. ducreyi to keratinocytes. we sought to determine the dom ... | 2009 | 19015257 |
| localization of the domains of the haemophilus ducreyi trimeric autotransporter dsra involved in serum resistance and binding to the extracellular matrix proteins fibronectin and vitronectin. | resisting the bactericidal activity of naturally occurring antibodies and complement of normal human serum is an important element in the evasion of innate immunity by bacteria. in the gram-negative mucosal pathogen haemophilus ducreyi, serum resistance is mediated primarily by the trimeric autotransporter dsra. dsra also functions as an adhesin for the extracellular matrix proteins fibronectin and vitronectin and mediates attachment of h. ducreyi to keratinocytes. we sought to determine the dom ... | 2009 | 19015257 |
| trimeric autotransporters of haemophilus parasuis: generation of an extensive passenger domain repertoire specific for pathogenic strains. | haemophilus parasuis is the agent responsible for causing glässer's disease, but little is known about the pathogenic determinants of this major pig disease. here we describe, for the pathogenic strain nagasaki, the molecular characterization of 13 trimeric autotransporters as assessed by the presence of yada c-terminal translocator domains which were classified into three groups. all passenger domains possess motifs and repeats characteristic of adhesins, hemagglutinins, and invasins with vario ... | 2009 | 19011035 |
| trimeric autotransporters of haemophilus parasuis: generation of an extensive passenger domain repertoire specific for pathogenic strains. | haemophilus parasuis is the agent responsible for causing glässer's disease, but little is known about the pathogenic determinants of this major pig disease. here we describe, for the pathogenic strain nagasaki, the molecular characterization of 13 trimeric autotransporters as assessed by the presence of yada c-terminal translocator domains which were classified into three groups. all passenger domains possess motifs and repeats characteristic of adhesins, hemagglutinins, and invasins with vario ... | 2009 | 19011035 |
| bacteriology in acute exacerbation of chronic obstructive pulmonary disease in patients admitted to hospital. | we investigated the bacterial flora and antimicrobial sensitivity in sputum from patients admitted to hospital with acute exacerbation of chronic obstructive pulmonary disease (aecopd) in order to recommend the best empirical treatment for these patients. the survey was a retrospective study of all patients admitted to hvidovre hospital with the diagnosis aecopd during 2004. a total of 118 patients were included. microscopy, culture and sensitivity testing investigated their sputums. clinical an ... | 2009 | 18855228 |
| multilocus sequence typing and pulsed field gel electrophoresis of otitis media causing pathogens. | streptococcus pneumoniae, haemophilus influenzae, and moraxella catarrhalis are the three leading bacteria species associated with otitis media. defining the molecular epidemiology of bacteria known to cause otitis media is of great importance, in both clinical and research settings. pfge and mlst provide data for the characterization of isolates' genetic relatedness, yet they differ in the types of studies for which they are most useful. consequently, knowledge of both techniques is important f ... | 2009 | 18839348 |
| the type 4 pili of enterohemorrhagic escherichia coli o157:h7 are multipurpose structures with pathogenic attributes. | enterohemorrhagic escherichia coli (ehec) o157:h7 produces long bundles of polar type 4 pili (t4p) called hcp (for hemorrhagic coli pili) that form physical bridges between bacteria associating with human and animal epithelial cells. here, we sought to further investigate whether hcp possessed other pathogenicity attributes associated with t4p production. comparative studies performed with wild-type ehec edl933 and an isogenic hcpa mutant revealed that hcp play different roles in the biology of ... | 2009 | 18952791 |
| the type 4 pili of enterohemorrhagic escherichia coli o157:h7 are multipurpose structures with pathogenic attributes. | enterohemorrhagic escherichia coli (ehec) o157:h7 produces long bundles of polar type 4 pili (t4p) called hcp (for hemorrhagic coli pili) that form physical bridges between bacteria associating with human and animal epithelial cells. here, we sought to further investigate whether hcp possessed other pathogenicity attributes associated with t4p production. comparative studies performed with wild-type ehec edl933 and an isogenic hcpa mutant revealed that hcp play different roles in the biology of ... | 2009 | 18952791 |
| determinants of moraxella catarrhalis colonization in healthy dutch children during the first 14 months of life. | moraxella catarrhalis is an established bacterial pathogen, previously thought to be an innocent commensal of the respiratory tract of children and adults. the objective of this study was to identify significant risk factors associated with m. catarrhalis colonization in the first year of life in healthy dutch children. this study investigated a target cohort group of 1079 children forming part of the generation r study, a population-based prospective cohort study following children from fetal l ... | 2010 | 19681950 |
| intrapulmonary pharmacokinetics of s-013420, a novel bicyclolide antibacterial, in healthy japanese subjects. | s-013420 (edp-420) is a novel bicyclolide (bridged bicyclic macrolide) antibacterial currently under development for the treatment of respiratory tract infections. the objective of the present study was to determine the plasma and intrapulmonary pharmacokinetic parameters of orally administered s-013420 in healthy volunteers. twenty-eight healthy japanese male subjects who never smoked were randomly allocated to seven groups of four subjects each who underwent bronchoalveolar lavage (bal) at dif ... | 2010 | 19933801 |
| new patterns in the otopathogens causing acute otitis media six to eight years after introduction of pneumococcal conjugate vaccine. | to describe np and aom otopathogens during the time frame 2007 to 2009, 6 to 8 years after the introduction of 7-valent pneumococcal conjugate (pcv7) in the united states and to compare nasopharyngeal (np) colonization and acute otitis media (aom) microbiology in children 6 to 36 months of age having first and second aom episodes with children who are otitis prone. | 2010 | 19935445 |
| correlation of bacterial colonization status between mother and child: the generation r study. | determinants of bacterial colonization in children have been described. in the generation r study, a population-based cohort study, we determined whether the colonization statuses of mothers and children are correlated. such a correlation was observed for staphylococcus aureus and haemophilus influenzae. direct transmission, genetic susceptibility and/or unidentified environmental factors may play a role here. | 2010 | 19940045 |
| correlation of bacterial colonization status between mother and child: the generation r study. | determinants of bacterial colonization in children have been described. in the generation r study, a population-based cohort study, we determined whether the colonization statuses of mothers and children are correlated. such a correlation was observed for staphylococcus aureus and haemophilus influenzae. direct transmission, genetic susceptibility and/or unidentified environmental factors may play a role here. | 2010 | 19940045 |
| a one-step, real-time pcr assay for rapid detection of rhinovirus. | one-step, real-time pcr assays for rhinovirus have been developed for a limited number of pcr amplification platforms and chemistries, and some exhibit cross-reactivity with genetically similar enteroviruses. we developed a one-step, real-time pcr assay for rhinovirus by using a sequence detection system (applied biosystems; foster city, ca). the primers were designed to amplify a 120-base target in the noncoding region of picornavirus rna, and a taqman (applied biosystems) degenerate probe was ... | 2010 | 19948820 |
| [moraxella catarrhalis sepsis in a 4 month-old infant with rsv+ bronchiolitis]. | 2010 | 19955027 | |
| rapid identification of bacteria in positive blood culture broths by matrix-assisted laser desorption ionization-time of flight mass spectrometry. | matrix-assisted laser desorption ionization-time of flight (maldi-tof) mass spectrometry is a rapid, accurate method for identifying bacteria and fungi recovered on agar culture media. we report herein a method for the direct identification of bacteria in positive blood culture broths by maldi-tof mass spectrometry. a total of 212 positive cultures were examined, representing 32 genera and 60 species or groups. the identification of bacterial isolates by maldi-tof mass spectrometry was compared ... | 2010 | 19955282 |
| rapid identification of bacteria in positive blood culture broths by matrix-assisted laser desorption ionization-time of flight mass spectrometry. | matrix-assisted laser desorption ionization-time of flight (maldi-tof) mass spectrometry is a rapid, accurate method for identifying bacteria and fungi recovered on agar culture media. we report herein a method for the direct identification of bacteria in positive blood culture broths by maldi-tof mass spectrometry. a total of 212 positive cultures were examined, representing 32 genera and 60 species or groups. the identification of bacterial isolates by maldi-tof mass spectrometry was compared ... | 2010 | 19955282 |
| lack of chlamydophila pneumoniae and predominance of alloiococcus otitidis in middle ear fluids of children with otitis media with effusion. | to investigate the presence of chlamydophila pneumoniae and other bacterial pathogens in middle ear effusion samples obtained from children with otitis media with effusion (ome). | 2010 | 19879704 |
| moraxella catarrhalis bacteraemia associated with prosthetic vascular graft infection. | moraxella catarrhalis, formerly called branhamella catarrhalis, 'neisseria catarrhalis' or 'micrococcus catarrhalis', is a gram-negative, aerobic diplococcus frequently found as a colonizer of the upper respiratory tract. over the last 20-30 years, this bacterium has emerged as a genuine pathogen, and is now considered an important cause of otitis media in children and an aetiological agent in pneumonia in adults with chronic obstructive pulmonary disease. however, bacteraemia due to m. catarrha ... | 2010 | 19850707 |
| the immunogenicity of the liposome-associated outer membrane proteins (omps) of moraxella catarrhalis. | the outer membrane proteins (omps) are the most immunogenic and attractive of the moraxella catarrhalis vaccine antigens that may induce the protective immune response. the aim of this study was to determine the effectiveness of two types of omp-associated phosphatidylcholine (pc) liposomal formulations (omps-pc, pc-omps) and of zwittergent-based proteomicelles (omps-z) in potentiating an anti-omp systemic immune response in mice. the immunogenicities of the above preparations were evaluated by ... | 2010 | 19851720 |
| in vitro activity of tigecycline against 2423 clinical isolates and comparison of the available interpretation breakpoints. | mics to tigecycline and 12 antimicrobials were performed by microdilution method, against 2423 nonduplicate pathogens recently isolated in 17 greek hospitals. the food and drug administration (fda) and european committee on antimicrobial susceptibility testing (eucast) criteria were used comparatively for interpretation of tigecycline mics. tigecycline exhibited potent in vitro activity against the majority of the isolates tested. (mic(90) values of 0.5, 1, 2, 0.125, 1, 0.25, 0.125, and 1 mg/l w ... | 2010 | 19836184 |
| immunopathogenesis of polymicrobial otitis media. | om, or inflammation of the middle ear, is a highly prevalent infection in children worldwide. om is a multifactorial disease with multiple risk factors, including preceding or concurrent viral urt infection. hence, om is also a polymicrobial disease. the mechanisms by which viruses predispose to bacterial om are replete; however, all are predicated on the general principle of compromise of primary host airway defenses. thus, despite an as-yet incomplete understanding of the molecular mechanisms ... | 2010 | 19843575 |
| immunopathogenesis of polymicrobial otitis media. | om, or inflammation of the middle ear, is a highly prevalent infection in children worldwide. om is a multifactorial disease with multiple risk factors, including preceding or concurrent viral urt infection. hence, om is also a polymicrobial disease. the mechanisms by which viruses predispose to bacterial om are replete; however, all are predicated on the general principle of compromise of primary host airway defenses. thus, despite an as-yet incomplete understanding of the molecular mechanisms ... | 2010 | 19843575 |
| protection against nontypeable haemophilus influenzae challenges by mucosal vaccination with a detoxified lipooligosaccharide conjugate in two chinchilla models. | otitis media (om) can occur following outset of upper respiratory tract infections. inhibition of bacterial colonization in nasopharynx (np) by mucosal vaccination may prevent om by reducing bacterial invasion of the middle ears (mes). in this study, 80 chinchillas were intranasally (i.n.) immunized with a detoxified lipooligosaccharide (dlos)-tetanus toxoid conjugate vaccine of nontypeable haemophilus influenzae (nthi) mixed with cholera toxin (ct) or ct alone. all vaccinated animals responded ... | 2010 | 19782149 |
| protection against nontypeable haemophilus influenzae challenges by mucosal vaccination with a detoxified lipooligosaccharide conjugate in two chinchilla models. | otitis media (om) can occur following outset of upper respiratory tract infections. inhibition of bacterial colonization in nasopharynx (np) by mucosal vaccination may prevent om by reducing bacterial invasion of the middle ears (mes). in this study, 80 chinchillas were intranasally (i.n.) immunized with a detoxified lipooligosaccharide (dlos)-tetanus toxoid conjugate vaccine of nontypeable haemophilus influenzae (nthi) mixed with cholera toxin (ct) or ct alone. all vaccinated animals responded ... | 2010 | 19782149 |
| [the role of macrolides in treatment of exacerbations of chronic obstructive pulmonary disease]. | exacerbations of chronic obstructive pulmonary disease (copd) cause a lot of hospital admissions, mortality, and strongly influence health-related quality of life. approximately half of copd exacerbations are associated with bacterial infections and many patients have lower airways colonization. current guidelines recommend antibotic therapy in course of copd exacerbation for patients with sputum purulence and suggest correlation between severity of symptoms and the type of infecting pathogen. t ... | 2010 | 20491344 |
| activity of a novel series of acylides active against community-acquired respiratory pathogens. | resistance to macrolides and beta-lactams has increased sharply amongst key respiratory pathogens, leading to major concern. a novel series of acylides was designed to overcome this resistance and was evaluated for in vitro and in vivo activity. this series of acylides was designed starting from clarithromycin by changing the substitution on the desosamine nitrogen, followed by conversion to 3-o-acyl and 11,12-carbamate. minimum inhibitory concentrations (mics) of acylides were determined agains ... | 2010 | 20493666 |
| simple sequence repeats and genome plasticity in streptococcus agalactiae. | simple sequence repeats (ssrs) and their role in phase variation have been extensively studied in gram-negative organisms, where they have been associated with antigenic variation and other adaptation strategies. in this study, we apply comparative genomics in order to find evidence of slipped-strand mispairing in the human gram-positive pathogen streptococcus agalactiae. in two consecutive screenings, 2,233 (650 + 1,583) ssrs were identified in our reference genome 2603v/r, and these loci were ... | 2010 | 20494995 |
| adenoidectomy and nasopharyngeal carriage of streptococcus pneumoniae in young children. | the effect of adenoidectomy on nasopharyngeal colonisation of pathogens has not previously been evaluated. the authors studied the effect of adenoidectomy on nasopharyngeal colonisation by bacteria causing otitis media and the effect of adenoidectomy on the development of pneumococcal capsular polysaccharide antibodies. | 2010 | 20504840 |
| evaluation of the analytical performance of the xpert mtb/rif assay. | we performed the first studies of analytic sensitivity, analytic specificity, and dynamic range for the new xpert mtb/rif assay, a nucleic acid amplification-based diagnostic system that detects mycobacterium tuberculosis and rifampin (rif) resistance in under 2 h. the sensitivity of the assay was tested with 79 phylogenetically and geographically diverse m. tuberculosis isolates, including 42 drug-susceptible isolates and 37 rif-resistant isolates containing 13 different rpob mutations or mutat ... | 2010 | 20504986 |
| community-acquired bloodstream infections in africa: a systematic review and meta-analysis. | data on the prevalence and causes of community-acquired bloodstream infections in africa are scarce. we searched three databases for studies that prospectively studied patients admitted to hospital with at least a blood culture, and found 22 eligible studies describing 58 296 patients, of whom 2051 (13.5%) of 15 166 adults and 3527 (8.2%) of 43 130 children had bloodstream infections. 1643 (29.1%) non-malaria bloodstream infections were due to salmonella enterica (58.4% of these non-typhoidal sa ... | 2010 | 20510282 |
| prediction of delayed recovery from pediatric community-acquired pneumonia. | if children with community-acquired pneumonia (cap) do not recover within 48 hours after starting antibiotic therapy, complications are possible and a checkup must be ensured.aim of the present study was to evaluate the improvement of pediatric cap, within 48 hours after starting therapy, in relation to age, etiology, clinical/laboratory characteristics and selected antibiotics. | 2010 | 20670443 |
| outbreak of corynebacterium pseudodiphtheriticum infection in cystic fibrosis patients, france. | an increasing body of evidence indicates that nondiphtheria corynebacteria may be responsible for respiratory tract infections. we report an outbreak of corynebacterium pseudodiphtheriticum infection in children with cystic fibrosis (cf). to identify 18 c. pseudodiphtheriticum strains isolated from 13 french children with cf, we used molecular methods (partial rpob gene sequencing) and matrix-assisted laser desorption ionization time-of-flight (maldi-tof) mass spectrometry. clinical symptoms wer ... | 2010 | 20678316 |
| discovery and analysis of 4h-pyridopyrimidines, a class of selective bacterial protein synthesis inhibitors. | bacterial protein synthesis is the target for numerous natural and synthetic antibacterial agents. we have developed a poly(u) mrna-directed aminoacylation/translation protein synthesis system composed of phenyl-trna synthetases, ribosomes, and ribosomal factors from escherichia coli. this system, utilizing purified components, has been used for high-throughput screening of a small-molecule chemical library. we have identified a series of compounds that inhibit protein synthesis with 50% inhibit ... | 2010 | 20696870 |
| new insights into the enigma of immunoglobulin d. | immunoglobulin d (igd) has remained a mysterious antibody class for almost half a century. igd was initially thought to be a recently evolved ig isotype expressed only by some mammalian species, but recent discoveries in fishes and amphibians demonstrate that igd was present in the ancestor of all jawed vertebrates and has important immunological functions. the structure of igd has been very dynamic throughout evolution. mammals can express igd through alternative splicing and class switch recom ... | 2010 | 20727035 |
| down-regulation of porin m35 in moraxella catarrhalis by aminopenicillins and environmental factors and its potential contribution to the mechanism of resistance to aminopenicillins. | the outer membrane protein m35 of moraxella catarrhalis is an antigenically conserved porin. knocking out m35 significantly increases the mics of aminopenicillins. the aim of this study was to determine the biological mechanism of this potentially new antimicrobial resistance mechanism of m. catarrhalis and the behaviour of m35 in general stress situations. | 2010 | 20801781 |
| sensitization of microcin j25-resistant strains by a membrane-permeabilizing peptide. | microcin j25 (mccj25) is a plasmid-encoded, 21-amino-acid, antibacterial peptide produced by escherichia coli. mccj25 inhibits rna polymerase and the membrane respiratory chain. mccj25 uptake into e. coli-sensitive strains is mediated by the outer membrane receptor fhua and the inner membrane proteins tonb, exbb, exbd, and sbma. this peptide is active on some e. coli, salmonella, and shigella species strains, while other gram-negative bacteria, such as clinical isolates of enterobacter cloacae, ... | 2010 | 20802073 |
| comparative analyses of the bacterial microbiota of the human nostril and oropharynx. | the nose and throat are important sites of pathogen colonization, yet the microbiota of both is relatively unexplored by culture-independent approaches. we examined the bacterial microbiota of the nostril and posterior wall of the oropharynx from seven healthy adults using two culture-independent methods, a 16s rrna gene microarray (phylochip) and 16s rrna gene clone libraries. while the bacterial microbiota of the oropharynx was richer than that of the nostril, the oropharyngeal microbiota vari ... | 2010 | 20802827 |
| indirect pathogenicity of haemophilus influenzae and moraxella catarrhalis in polymicrobial otitis media occurs via interspecies quorum signaling. | otitis media (om) is among the leading diseases of childhood and is caused by opportunists that reside within the nasopharynx, such as haemophilus influenzae and moraxella catarrhalis. as with most airway infections, it is now clear that om infections involve multiple organisms. this study addresses the hypothesis that polymicrobial infection alters the course, severity, and/or treatability of om disease. the results clearly show that coinfection with h. influenzae and m. catarrhalis promotes th ... | 2010 | 20802829 |
| prevalence of antimicrobial-resistant pathogens in canadian hospitals: results of the canadian ward surveillance study (canward 2008). | a total of 5,282 bacterial isolates obtained between 1 january and 31 december 31 2008, inclusive, from patients in 10 hospitals across canada as part of the canadian ward surveillance study (canward 2008) underwent susceptibility testing. the 10 most common organisms, representing 78.8% of all clinical specimens, were as follows: escherichia coli (21.4%), methicillin-susceptible staphylococcus aureus (mssa; 13.9%), streptococcus pneumoniae (10.3%), pseudomonas aeruginosa (7.1%), klebsiella pneu ... | 2010 | 20805395 |
| vitronectin in bacterial pathogenesis: a host protein used in complement escape and cellular invasion. | the multifunctional human glycoprotein vitronectin (vn) plays a significant role in cell migration, tissue repair and regulation of membrane attack complex (mac) formation. it also promotes neutrophil infiltration and, thus, enhances the inflammatory process during infection. in the host, a balanced homeostasis is maintained by vn due to neutralization of the self-reactivity of the mac. on the other hand, vn bound to the bacterial surface protects from mac-mediated lysis and enhances adhesion. g ... | 2010 | 20807208 |
| the synthetic bacterial lipopeptide pam3csk4 modulates respiratory syncytial virus infection independent of tlr activation. | respiratory syncytial virus (rsv) is an important cause of acute respiratory disease in infants, immunocompromised subjects and the elderly. however, it is unclear why most primary rsv infections are associated with relatively mild symptoms, whereas some result in severe lower respiratory tract infections and bronchiolitis. since rsv hospitalization has been associated with respiratory bacterial co-infections, we have tested if bacterial toll-like receptor (tlr) agonists influence rsv-a2-gfp inf ... | 2010 | 20808895 |
| moraxella catarrhalis: an unrecognized pathogen of the oral cavity? | abstract objective: we investigated the effect of the bacterial flora of the nose and throat on the outcome of the initial repairs of the cleft palate in the presence of prophylactic antibiotics. design: a retrospective review of 90 procedures in 66 patients who had cleft palate repair between april 2005 and june 2007 was carried out at booth hall children's hospital, manchester, uk. both isolated cleft palate (cp) and cleft lip and palate (clp) patients were included. exclusion criteria include ... | 2010 | 20815726 |
| specificity in killing pathogens is mediated by distinct repertoires of human neutrophil peptides. | neutrophil-derived antimicrobial peptides and proteins (amps) play an important role in the defense against microbes. absence of defense is illustrated by neutropenic patients with frequent bacterial and fungal infections. however, the specificity of the antimicrobial effects has not been adequately described. we set out to determine the specific antimicrobial pattern of polypeptides in neutrophils (polymorphonuclear leukocytes, pmns) against 4 potential human pathogens: moraxella catarrhalis, s ... | 2010 | 20820100 |
| development of a novel dna microarray to detect bacterial pathogens in patients with chronic obstructive pulmonary disease (copd). | a novel microarray was constructed with dna pcr product probes targeting species specific functional genes of nine clinically significant respiratory pathogens, including the gram-positive organisms (streptococcus pneumoniae, streptococcus pyogenes), the gram-negative organisms (chlamydia pneumoniae, coxiella burnetii haemophilus spp., legionella pneumophila, moraxella catarrhalis, and pseudomonas aeruginosa), as well as the atypical bacterium, mycoplasma pneumoniae. in a "proof-of-concept" eval ... | 2010 | 20074591 |
| in vitro antibacterial activities of s-013420, a novel bicyclolide, against respiratory tract pathogens. | the in vitro activity of s-013420, a novel bicyclolide, was investigated. | 2010 | 20472695 |
| expression of xylella fastidiosa fimbrial and afimbrial proteins during biofilm formation. | complete sequencing of the xylella fastidiosa genome revealed characteristics that have not been described previously for a phytopathogen. one characteristic of this genome was the abundance of genes encoding proteins with adhesion functions related to biofilm formation, an essential step for colonization of a plant host or an insect vector. we examined four of the proteins belonging to this class encoded by genes in the genome of x. fastidiosa: the pila2 and pilc fimbrial proteins, which are co ... | 2010 | 20472735 |
| single assay for simultaneous detection and differential identification of human and avian influenza virus types, subtypes, and emergent variants. | for more than four decades the cause of most type a influenza virus infections of humans has been attributed to only two viral subtypes, a/h1n1 or a/h3n2. in contrast, avian and other vertebrate species are a reservoir of type a influenza virus genome diversity, hosting strains representing at least 120 of 144 combinations of 16 viral hemagglutinin and 9 viral neuraminidase subtypes. viral genome segment reassortments and mutations emerging within this reservoir may spawn new influenza virus str ... | 2010 | 20140251 |
| biochemical analysis of lgt3, a glycosyltransferase of the bacterium moraxella catarrhalis. | the lipooligosaccharide (los) of moraxella catarrhalis is unusual in that it lacks heptose. the sugar linking oligosaccharide to lipid a is a trisubstituted glucose. a single enzyme, lgt3, is suggested to trisubstitute this core sugar. the lgt3 gene encodes two distinct domains with high similarity to glucosyltransferases of the gt-a superfamily, thus encoding a bidomain, multifunctional glucosyltransferase. to characterise lgt3, the gene was amplified from m. catarrhalis, expressed in escherich ... | 2010 | 20153730 |
| spectrum of activity, mutation rates, synergistic interactions, and the effects of ph and serum proteins for fusidic acid (cem-102). | fusidic acid (cem-102) is a steroidal antimicrobial agent with focused gram-positive activity that acts by preventing bacterial protein synthesis via interacting with elongation factor g. a collection of 114 wild-type isolates (> 80 species) was used to define the contemporary limits of fusidic acid spectrum against gram-positive and gram-negative species. reference broth microdilution and anaerobic agar dilution methods were performed. modifications of standardized test methods included adding ... | 2010 | 20159376 |
| the bps polysaccharide of bordetella pertussis promotes colonization and biofilm formation in the nose by functioning as an adhesin. | many respiratory pathogens establish persistent infection or a carrier state in the human nasopharynx without overt disease symptoms but the presence of these in the lungs usually results in disease. although the anatomy and microenvironments between nasopharynx and lungs are different, a virulence factor with an organ-specific function in the colonization of the nasopharynx is unknown. in contrast to the severity of pertussis and mortality in non-vaccinated young children, bordetella pertussis ... | 2010 | 20633227 |
| correlation of viral load of respiratory pathogens and co-infections with disease severity in children hospitalized for lower respiratory tract infection. | the clinical significance of viral load and co-infections in children with respiratory infections is not clear. | 2010 | 20646956 |
| exposing rodents to a combination of tobacco smoke and lipopolysaccharide results in an exaggerated inflammatory response in the lung. | acute exacerbations of chronic obstructive pulmonary disease (copd), which are often associated with respiratory infections, are defined as a worsening of symptoms that require a change in medication. exacerbations are characterized by a reduction in lung function, quality of life and are associated with increased pro-inflammatory mediators in the lung. our aim was to develop an animal model to mimic aspects of this exaggerated inflammatory response by combining key etiological factors, tobacco ... | 2010 | 20649596 |
| tracing phylogenomic events leading to diversity of haemophilus influenzae and the emergence of brazilian purpuric fever (bpf)-associated clones. | here we report the use of a multi-genome dna microarray to elucidate the genomic events associated with the emergence of the clonal variants of haemophilus influenzae biogroup aegyptius causing brazilian purpuric fever (bpf), an important pediatric disease with a high mortality rate. we performed directed genome sequencing of strain hk1212 unique loci to construct a species dna microarray. comparative genome hybridization using this microarray enabled us to determine and compare gene complements ... | 2010 | 20654709 |
| respiratory bacterial pathogens in the nasopharynx and lower airways of australian indigenous children with bronchiectasis. | to test the hypothesis that bacterial density, strain diversity, and concordance of pathogens between upper and lower airways are higher in children with bronchiectasis than in those with non-bronchiectatic conditions. | 2010 | 20656297 |
| biochemical and functional characterization of helicobacter pylori vesicles. | helicobacter pylori can cause peptic ulcer disease and/or gastric cancer. adhesion of bacteria to the stomach mucosa is an important contributor to the vigour of infection and resulting virulence. h. pylori adheres primarily via binding of baba adhesins to abo/lewis b (leb) blood group antigens and the binding of saba adhesins to sialyl-lewis x/a (slex/a) antigens. similar to most gram-negative bacteria, h. pylori continuously buds off vesicles and vesicles derived from pathogenic bacteria often ... | 2010 | 20659286 |
| efficacy and safety of nemonoxacin versus levofloxacin for community-acquired pneumonia. | nemonoxacin, a novel nonfluorinated quinolone, exhibits potent in vitro and in vivo activities against community-acquired pneumonia (cap) pathogens, including multidrug-resistant streptococcus pneumoniae. patients with mild to moderate cap (n = 265) were randomized to receive oral nemonoxacin (750 mg or 500 mg) or levofloxacin (500 mg) once daily for 7 days. clinical responses were determined at the test-of-cure visit in intent-to-treat (itt), clinical per protocol (ppc), evaluable-itt, and eval ... | 2010 | 20660689 |
| a decade of non-cystic fibrosis bronchiectasis 1996-2006. | this study aimed to determine the aetiology, clinical presentation, co-morbidity, severity and the lobar distribution of non cystic fibrosis bronchiectasis (ncfb). we performed a retrospective review of clinical, radiological, immunological and microbiological data from 92 non-cf patients with a high resolution thoracic ct (hrct) diagnosis of bronchiectasis in the three dublin children's referral hospitals for the period 1996-2006. of 92 patients (50 female), the median age at diagnosis was 6.4 ... | 2010 | 20666070 |
| colistin resistance in acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production. | infections caused by multidrug-resistant (mdr) gram-negative bacteria represent a major global health problem. polymyxin antibiotics such as colistin have resurfaced as effective last-resort antimicrobials for use against mdr gram-negative pathogens, including acinetobacter baumannii. here we show that a. baumannii can rapidly develop resistance to polymyxin antibiotics by complete loss of the initial binding target, the lipid a component of lipopolysaccharide (lps), which has long been consider ... | 2010 | 20855724 |
| in vitro and in vivo activities of lcb01-0371, a new oxazolidinone. | lcb01-0371 is a new oxazolidinone with cyclic amidrazone. in vitro activity of lcb01-0371 against 624 clinical isolates was evaluated and compared with those of linezolid, vancomycin, and other antibiotics. lcb01-0371 showed good activity against gram-positive pathogens. in vivo activity of lcb01-0371 against systemic infections in mice was also evaluated. lcb01-0371 was more active than linezolid against these systemic infections. lcb01-0371 showed bacteriostatic activity against staphylococcus ... | 2010 | 20855730 |
| nested pcr-linked capillary electrophoresis and single-strand conformation polymorphisms for detection of macrolide-resistant mycoplasma pneumoniae in beijing, china. | mycoplasma pneumoniae is usually susceptible to macrolides, but macrolide-resistant strains have been found frequently in recent years. mutations in domain v of the 23s rrna gene of m. pneumoniae interfere with the binding of macrolides to rrna and mediate macrolide resistance. in this study, we developed a rapid and inexpensive method that combines nested pcr (npcr), single-strand conformation polymorphisms (sscps), and capillary electrophoresis (ce) to detect macrolide-resistant mutants direct ... | 2010 | 20861333 |
| structure of a burkholderia pseudomallei trimeric autotransporter adhesin head. | pathogenic bacteria adhere to the host cell surface using a family of outer membrane proteins called trimeric autotransporter adhesins (taas). although taas are highly divergent in sequence and domain structure, they are all conceptually comprised of a c-terminal membrane anchoring domain and an n-terminal passenger domain. passenger domains consist of a secretion sequence, a head region that facilitates binding to the host cell surface, and a stalk region. | 2010 | 20862217 |
| pneumococcal carriage is more common in asthmatic than in non-asthmatic young men. | the aim was to investigate the prevalence of oropharyngeal carriage of streptococcus pneumoniae, haemophilus influenzae, moraxella catarrhalis, neisseria meningitidis and beta-haemolytic streptococci among asthmatic and non-asthmatic young finnish men and to identify putative risk factors. | 2010 | 20887345 |
| identification of burkholderia mallei and burkholderia pseudomallei adhesins for human respiratory epithelial cells. | burkholderia pseudomallei and burkholderia mallei cause the diseases melioidosis and glanders, respectively. a well-studied aspect of pathogenesis by these closely-related bacteria is their ability to invade and multiply within eukaryotic cells. in contrast, the means by which b. pseudomallei and b. mallei adhere to cells are poorly defined. the purpose of this study was to identify adherence factors expressed by these organisms. | 2010 | 20920184 |
| development and characterization of protective haemophilus parasuis subunit vaccines based on native proteins with affinity to porcine transferrin and comparison with other subunit and commercial vaccines. | haemophilus parasuis is the agent responsible for causing glässer's disease, which is characterized by fibrinous polyserositis, polyarthritis, and meningitis in pigs. in this study, we have characterized native outer membrane proteins with affinity to porcine transferrin (npapt) from h. parasuis serovar 5, nagasaki strain. this pool of proteins was used as antigen to developed two vaccine formulations: one was adjuvanted with a mineral oil (montanide ims 2215 vg pr), while the other was potentia ... | 2010 | 20926701 |
| development and characterization of protective haemophilus parasuis subunit vaccines based on native proteins with affinity to porcine transferrin and comparison with other subunit and commercial vaccines. | haemophilus parasuis is the agent responsible for causing glässer's disease, which is characterized by fibrinous polyserositis, polyarthritis, and meningitis in pigs. in this study, we have characterized native outer membrane proteins with affinity to porcine transferrin (npapt) from h. parasuis serovar 5, nagasaki strain. this pool of proteins was used as antigen to developed two vaccine formulations: one was adjuvanted with a mineral oil (montanide ims 2215 vg pr), while the other was potentia ... | 2010 | 20926701 |
| serum intercellular adhesion molecule 1 variations in young children with acute otitis media. | acute otitis media (aom) is an inflammatory reaction in the middle ear, most often occurring in young children. streptococcus pneumoniae, nontypeable haemophilus influenzae, and moraxella catarrhalis are the most common bacteria isolated. intercellular adhesion molecule 1 (icam-1) is involved in the innate immune response to infection by microorganisms, in effective antigen presentation, and in subsequent t-cell activation. here we prospectively studied levels of serum soluble icam-1 (sicam-1) b ... | 2010 | 20926702 |
| infections of people with complement deficiencies and patients who have undergone splenectomy. | the complement system comprises several fluid-phase and membrane-associated proteins. under physiological conditions, activation of the fluid-phase components of complement is maintained under tight control and complement activation occurs primarily on surfaces recognized as "nonself" in an attempt to minimize damage to bystander host cells. membrane complement components act to limit complement activation on host cells or to facilitate uptake of antigens or microbes "tagged" with complement fra ... | 2010 | 20930072 |
| prolonged use of ertapenem to treat infected diabetic foot ulcers. | we present the case of a diabetic man who was successfully treated with ertapenem for over 4 months for severe infection of his foot ulcers. after initial unsuccessful treatment with empirical intravenous antibiotics, ertapenem was started on microbiology advice and led to a marked improvement in the soft-tissue infection. ertapenem was continued for a total of 137 days under close clinical and biochemical monitoring and produced a complete resolution of the foot infection. this is the first doc ... | 2010 | 20936155 |
| nasopharyngeal bacterial colonization during the first wheezing episode is associated with longer duration of hospitalization and higher risk of relapse in young children. | the purpose of this study was to examine the association between bacterial colonization/infection and respiratory outcomes in children younger than 3 years old who were hospitalized for their first wheezing episode. this was an observational study. the primary outcome was hospitalization time and the secondary outcomes included relapses within 2 months and time to recurrent wheezing (i.e. three physician confirmed wheezing episodes) within 12 months. bacterial antibody assays for streptococcus p ... | 2010 | 20938703 |
| the multifunctional host defense peptide splunc1 is critical for homeostasis of the mammalian upper airway. | otitis media (om) is a highly prevalent pediatric disease caused by normal flora of the nasopharynx that ascend the eustachian tube and enter the middle ear. as om is a disease of opportunity, it is critical to gain an increased understanding of immune system components that are operational in the upper airway and aid in prevention of this disease. splunc1 is an antimicrobial host defense peptide that is hypothesized to contribute to the health of the airway both through bactericidal and non-bac ... | 2010 | 20949060 |
| antimicrobial activity of doripenem and other carbapenems against gram-negative pathogens from korea. | a total of 950 gram-negative bacterial isolates from patients with bacteremia and urinary tract infections were collected from tertiary-care hospitals in korea. in vitro antimicrobial susceptibility testing was performed using broth microdilution test according to clinical and laboratory standards institute protocol. in general, carbapenems such as doripenem, imipenem, and meropenem were very active against enterobacteriaceae, moraxella catarrhalis, pseudomonas aeruginosa, and acinetobacter sp. ... | 2010 | 20950191 |
| etiology and antibacterial susceptibility pattern of community-acquired bacterial ocular infections in a tertiary eye care hospital in south india. | to identify the etiology, incidence and prevalence of ocular bacterial infections, and to assess the in vitro susceptibility of these ocular bacterial isolates to commonly used antibiotics. | 2010 | 20952834 |
| molecular characterization of fluoroquinolone resistance in mycobacterium tuberculosis: functional analysis of gyra mutation at position 74. | a pcr-sequencing assay was evaluated for direct detection of mutations in the quinolone resistance-determining region (qrdr) of gyrase a (gyra) gene in fluoroquinolone-resistant mycobacterium tuberculosis in respiratory specimens. as determined by gyra qrdr analysis, complete concordance of genotypic and phenotypic fluoroquinolone resistance was demonstrated. our results indicate that the assay is a rapid and reliable method for the diagnosis of fluoroquinolone-resistant tuberculosis, facilitati ... | 2010 | 20956608 |
| molecular characterization of fluoroquinolone resistance in mycobacterium tuberculosis: functional analysis of gyra mutation at position 74. | a pcr-sequencing assay was evaluated for direct detection of mutations in the quinolone resistance-determining region (qrdr) of gyrase a (gyra) gene in fluoroquinolone-resistant mycobacterium tuberculosis in respiratory specimens. as determined by gyra qrdr analysis, complete concordance of genotypic and phenotypic fluoroquinolone resistance was demonstrated. our results indicate that the assay is a rapid and reliable method for the diagnosis of fluoroquinolone-resistant tuberculosis, facilitati ... | 2010 | 20956608 |
| microbes responsible for acute exacerbation of copd. | this study was designed to find out the microbes responsible for acute exacerbation of chronic obstructive pulmonary disease (copd). this study was carried out in the national institute of diseases of the chest & hospital (nidch), dhaka during the period of january 2003 to december 2003. the study was a prospective case control study. there were 88 male and 2 female patients. the majority of the study subjects fell within the range of 50-70 years. all were smokers. 30 stable copd patients were t ... | 2010 | 20956903 |
| resistance and the management of complicated skin and skin structure infections: the role of ceftobiprole. | antimicrobial resistant bacteria are an increasing concern due to the resulting increase in morbidity, mortality, and health-care costs associated with the administration of inadequate or delayed antimicrobial therapy. the implications of inadequate antimicrobial therapy in complicated skin and skin structure infections (csssis) have gained more attention recently, most likely due to the recent emergence of community-acquired methicillin resistant staphylococcus aureus (mrsa) and the already hig ... | 2010 | 20957140 |
| potential of ceragenin csa-13 and its mixture with pluronic f-127 as treatment of topical bacterial infections. | ceragenin csa-13 is a synthetic mimic of cationic antibacterial peptides, with facial amphiphilic morphology reproduced using a cholic acid scaffold. previous data have shown that this molecule displays broad-spectrum antibacterial activity, which decreases in the presence of blood plasma. however, at higher concentrations, csa-13 can cause lysis of erythrocytes. this study was designed to assess in vitro antibacterial and haemolytic activity of csa-13 in the presence of pluronic f-127. | 2010 | 20961363 |
| potential of ceragenin csa-13 and its mixture with pluronic f-127 as treatment of topical bacterial infections. | ceragenin csa-13 is a synthetic mimic of cationic antibacterial peptides, with facial amphiphilic morphology reproduced using a cholic acid scaffold. previous data have shown that this molecule displays broad-spectrum antibacterial activity, which decreases in the presence of blood plasma. however, at higher concentrations, csa-13 can cause lysis of erythrocytes. this study was designed to assess in vitro antibacterial and haemolytic activity of csa-13 in the presence of pluronic f-127. | 2010 | 20961363 |
| molecular probes for diagnosis of clinically relevant bacterial infections in blood cultures. | broad-range real-time pcr and sequencing of the 16s rrna gene region is a widely known method for the detection and identification of bacteria in clinical samples. however, because of the need for sequencing, such identification of bacteria is time-consuming. the aim of our study was to develop a more rapid 16s real-time pcr-based identification assay using species- or genus-specific probes. the gram-negative bacteria were divided into pseudomonas species, pseudomonas aeruginosa, escherichia col ... | 2010 | 20962139 |
| epidemiology of nasopharyngeal carriage of respiratory bacterial pathogens in children and adults: cross-sectional surveys in a population with high rates of pneumococcal disease. | to determine the prevalence of carriage of respiratory bacterial pathogens, and the risk factors for and serotype distribution of pneumococcal carriage in an australian aboriginal population. | 2010 | 20969800 |
| mapping of the neisseria meningitidis nada cell-binding site: relevance of predicted {alpha}-helices in the nh2-terminal and dimeric coiled-coil regions. | nada is a trimeric autotransporter protein of neisseria meningitidis belonging to the group of oligomeric coiled-coil adhesins. it is implicated in the colonization of the human upper respiratory tract by hypervirulent serogroup b n. meningitidis strains and is part of a multiantigen anti-serogroup b vaccine. structure prediction indicates that nada is made by a cooh-terminal membrane anchor (also necessary for autotranslocation to the bacterial surface), an intermediate elongated coiled-coil-ri ... | 2010 | 20971901 |
| mapping of the neisseria meningitidis nada cell-binding site: relevance of predicted {alpha}-helices in the nh2-terminal and dimeric coiled-coil regions. | nada is a trimeric autotransporter protein of neisseria meningitidis belonging to the group of oligomeric coiled-coil adhesins. it is implicated in the colonization of the human upper respiratory tract by hypervirulent serogroup b n. meningitidis strains and is part of a multiantigen anti-serogroup b vaccine. structure prediction indicates that nada is made by a cooh-terminal membrane anchor (also necessary for autotranslocation to the bacterial surface), an intermediate elongated coiled-coil-ri ... | 2010 | 20971901 |
| [evaluation of the safety and efficacy of cefditoren pivoxil fine granules for pediatric use in pediatric patients with acute otitis media]. | a clinical practice guideline for the diagnosis and management of acute otitis media in children, in view of the causative organisms of the disease and their drug susceptibility, was issued in march 2006. in the guideline, cefditoren pivoxil (cdtr-pi, meiact ms fine granules 10% for pediatric use) is recommended as an oral cephem antibiotic for the treatment of the disease. to collect information on the appropriate use of the drug in the clinical setting after issuance of the guideline, we condu ... | 2010 | 20976878 |
| differences in nasopharyngeal bacterial carriage in preschool children from different socio-economic origins. | clin microbiol infect abstract: a prospective cohort study of preschool healthy children (3-6 years old) from two distinct socio-economic settings in the brussels area, belgium, was conducted during the years 2006-2008. the objectives were to evaluate nasopharyngeal colonization by streptococcus pneumoniae, staphylococcus aureus, moraxella catarrhalis and haemophilus influenzae at the time of pcv7 vaccine introduction and to assess the socio-economic level impact on flora composition and antibio ... | 2010 | 20977542 |
| topical ciprofloxacin is superior to topical saline and systemic antibiotics in the treatment of tympanostomy tube otorrhea in children: the results of a randomized clinical trial. | to compare the clinical failure rates among children with otorrhea through tympanostomy tubes treated with topical or systemic antibiotics versus topical saline. | 2010 | 20979100 |
| bacterial infections and pediatric asthma. | streptococcus pneumoniae, haemophilus influenzae and moraxella catarrhalis seem to have no role in asthma in children. mycoplasma pneumoniae and chlamydophila pneumoniae can induce wheezing and cause asthma exacerbations in children, and chronic chlamydophila infections may even participate in asthma pathogenesis. however, studies have failed to show any benefits from antibiotics for incipient or stable pediatric asthma, as well as for asthma exacerbations in children. exposure to antibiotics in ... | 2010 | 21029939 |
| adhesive activity of the haemophilus cryptic genospecies cha autotransporter is modulated by variation in tandem peptide repeats. | the haemophilus cryptic genospecies is an important cause of maternal genital tract and neonatal systemic infections and initiates infection by colonizing the genital or respiratory epithelium. in recent work, we identified a unique haemophilus cryptic genospecies protein called cha, which mediates efficient adherence to genital and respiratory epithelia. the cha adhesin belongs to the trimeric autotransporter family and contains an n-terminal signal peptide, an internal passenger domain that ha ... | 2010 | 21037000 |
| adhesive activity of the haemophilus cryptic genospecies cha autotransporter is modulated by variation in tandem peptide repeats. | the haemophilus cryptic genospecies is an important cause of maternal genital tract and neonatal systemic infections and initiates infection by colonizing the genital or respiratory epithelium. in recent work, we identified a unique haemophilus cryptic genospecies protein called cha, which mediates efficient adherence to genital and respiratory epithelia. the cha adhesin belongs to the trimeric autotransporter family and contains an n-terminal signal peptide, an internal passenger domain that ha ... | 2010 | 21037000 |