Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| epidemiology of acute otitis media in the postpneumococcal conjugate vaccine era. | to study the epidemiology of acute otitis media (aom), especially the otitis-prone condition, during the pneumococcal conjugate vaccines 7 and 13 era. | 2017 | 28784702 |
| burden of lower respiratory infections in the eastern mediterranean region between 1990 and 2015: findings from the global burden of disease 2015 study. | we used data from the global burden of disease 2015 study (gbd) to calculate the burden of lower respiratory infections (lris) in the 22 countries of the eastern mediterranean region (emr) from 1990 to 2015. | 2017 | 28776246 |
| fluorescence imaging of streptococcus pneumoniae with the helix pomatia agglutinin (hpa) as a potential, rapid diagnostic tool. | streptococcus pneumoniae is a common human pathogen and a major causal agent of life-threatening infections that can either be respiratory or non-respiratory. it is well known that the helix pomatia (edible snail) agglutinin (hpa) lectin shows specificity for terminal αgalnac residues present, among other locations, in the forssman pentasaccharide (αgalnac1→3βgalnac1→3αgal1→4βgal1→4βglc). based on experiments involving choline-independent mutants and different growth conditions, we propose here ... | 2017 | 28769901 |
| vaccine-preventable diseases requiring hospitalization. | plain children often have lower immunization rates than non-plain children. penn state health children's hospital is a tertiary medical center with large nearby plain (amish and mennonite) communities. we sought to describe the characteristics of children hospitalized with vaccine-preventable diseases (vpds). we hypothesized that amish children would have a higher risk of vpds than non-amish children. | 2017 | 28768853 |
| pd-l2 regulates b-1 cell antibody production against phosphorylcholine through an il-5-dependent mechanism. | b-1 cells produce natural abs which provide an integral first line of defense against pathogens while also performing important homeostatic housekeeping functions. in this study, we demonstrate that programmed cell death 1 ligand 2 (pd-l2) regulates the production of natural abs against phosphorylcholine (pc). naive pd-l2-deficient (pd-l2(-/-)) mice produced significantly more pc-reactive igm and iga. this afforded pd-l2(-/-) mice with selectively enhanced protection against pc-expressing nontyp ... | 2017 | 28768724 |
| immunogenicity of nontypeable haemophilus influenzae outer membrane vesicles and protective ability in the chinchilla model of otitis media. | outer membrane vesicles (omvs) produced by gram-negative bacteria are enriched in several outer membrane components, including major and minor outer membrane proteins and lipooligosaccharide. we assessed the functional activity of nontypeable haemophilus influenzae (nthi) omv-specific antisera and the protective ability of nthi omvs as vaccine antigens in the chinchilla otitis media model. omvs were purified from three hmw1/hmw2-expressing nthi strains, two of which were also engineered to overe ... | 2017 | 28768669 |
| frequency of acute otitis media in children under 24 months of age before and after the introduction of the 10-valent pneumococcal conjugate vaccine into the national immunization program in chile. | streptococcus pneumoniae is the leading cause of acute otitis media (aom). pneumococcal non-typable haemophilus influenzae protein d conjugate vaccine (pcv-10) was introduced to the chilean national immunization program (nip) in 2011. the aim of this study was to estimate the frequency of aom in children < 24 months of age attending the emergency department (ed) of hospital sótero del río (hsr) 4 years before and 4 years after the introduction of pcv-10 in the chilean nip. | 2017 | 28763425 |
| haemophilus influenzae type b meningitis in a vaccinated and immunocompetent child. | 2017 | 28757297 | |
| serum antibody response to moraxella catarrhalis proteins in stringently defined otitis prone children. | moraxella catarrhalis (mcat) is a frequent pathogen of acute otitis media (aom) in young children. here we prospectively assessed naturally-induced serum antibodies to four mcat vaccine candidate proteins in stringently defined otitis prone (sop) and non-otitis prone (nop) children age 6-36months old following nasopharyngeal (np) colonization, at onset of aom and convalescence from aom. | 2017 | 28755833 |
| [neisseria gonorrhoeae: an infrequent causal agent of periorbital cellulitis in a child]. | periorbital cellulitis is a very common disease in pediatric population, it describes an infection involving the adjacent soft tissues anterior to the orbital septum. pathogens involved are generally gram-positive cocci after introduction of haemophilus influenzae vaccine. we report a case of neisseria gonorrhoeae periorbital cellulitis associated with bacterial conjunctivitis in a child. there are few cases reported in the literature with this microorganism as the causal agent. with this case, ... | 2017 | 28737877 |
| economic evaluations of haemophilus influenzae type b (hib) vaccine: a systematic review. | the world health organization (who) recommends the use of haemophilus influenzae type b (hib) conjugate vaccines, but china and thailand have not used hib vaccination in their national immunization programs. this systematic review aimed to update published economic evaluations of hib vaccinations and to determine factors that potentially affected their cost-effectiveness. | 2017 | 28737468 |
| recombinant truncated e protein as a new vaccine candidate against nontypeable h. influenzae: its expression and immunogenic evaluation. | protein e (pe) is a conserved entity observed in both nontypeable haemophilus influenzae (nthi) and encapsulated h. influenzae. this is a small surface lipoprotein, consisting of only 160 amino acids, involved in the adhesion of h. influenzae to various types of epithelial cells. a 384-bp-long fragment from nthi pe was cloned into the prokaryotic expression vector pbad-giiia. the recombinant protein was expressed with arabinose and then purified by affinity purification on an ni-nta agarose matr ... | 2017 | 28735080 |
| selective igm deficiency: clinical and laboratory features of 17 patients and a review of the literature. | primary selective igm deficiency (sigmd) is a primary immunodeficiency with unclear pathogenesis and a low number of published cases. | 2017 | 28730517 |
| haemophilus influenzae serotype f endocarditis and septic arthritis. | haemophilus influenzae represents gram-negative coccobacilli which can cause endocarditis, meningitis, septicemia, pneumonia, septic arthritis. h.influenzae exists as encapsulated and unencapsulated (non-typeable) strains. non-typeable h.influenzae are emerging pathogens especially in elderly population. we report a case of a 73 year old woman with bacteremia, endocarditis and septic arthritis due to h.influenzae serotype f. this case emphasizes the clinical features and the key elements of diag ... | 2017 | 28725560 |
| determining optimal dosing regimen of oral administration of dicloxacillin using monte carlo simulation. | dicloxacillin, a semisynthetic isoxazolyl penicillin, exhibits antimicrobial activity against a wide variety of gram-positive bacteria, as well as stability against penicillinases and low level of toxicity. the objective of this study was to obtain optimal dosing regimen of oral administration of dicloxacillin by analyzing the pharmacokinetic (pk) index in healthy volunteers and in vitro antibacterial activity by using monte carlo simulation. | 2017 | 28721014 |
| development of antimicrobial nanoemulsion-based delivery systems against selected pathogenic bacteria using a thymol rich thymus daenensis essential oil. | thymol rich medicinal plants have been used in traditional medicine to relieve infectious diseases. however, the application of essential oils as medicine is limited by its low water-solubility and high vapor pressure. the objective of this study was to produce stable nanoemulsions of thymus daenensis oil in water by preventing ostwald ripening and phase separation. | 2017 | 28714250 |
| nasopharyngeal microbiota in infants and changes during viral upper respiratory tract infection and acute otitis media. | interferences between pathogenic bacteria and specific commensals are known. we determined the interactions between nasopharyngeal microbial pathogens and commensals during viral upper respiratory tract infection (uri) and acute otitis media (aom) in infants. | 2017 | 28708872 |
| acute otitis media in children. | acute otitis media is a common childhood infection. prompt diagnosis and appropriate treatment are very important. | 2017 | 28707578 |
| the evidence for non-typeable haemophilus influenzae as a causative agent of childhood pneumonia. | haemophilus influenzae type b (hib) was a major cause of bacterial pneumonia in children prior to the introduction of hib-conjugate vaccines. the widespread use of hib-conjugate vaccines has resulted in a significant decline in the number of cases of invasive hib disease, including bacteraemic pneumonia, in areas where the vaccine has been implemented. in many countries, non-typeable h. influenzae (nthi) is now the most common cause of invasive haemophilus infection in all ages. nthi are a recog ... | 2017 | 28702311 |
| childhood pneumonia and meningitis in the eastern highlands province, papua new guinea in the era of conjugate vaccines: study methods and challenges. | pneumonia and meningitis are common causes of severe childhood illness in papua new guinea (png). the etiology of both clinical conditions in png has not been recently assessed. changes in lifestyle, provision and access to healthcare, antimicrobial utilization and resistance, and the national childhood vaccination schedule necessitate reassessment. | 2017 | 28702307 |
| investigations of a possible chemical effect of salvadora persica chewing sticks. | salvadora persica is commonly used chewing sticks in many parts of the world as an oral hygiene tool. this study measured the amount of benzyl isothiocyanate (bitc) released into the mouth and assessed its retention time in saliva. the study also tested if the released amount of bitc could potentially be antibacterial or cytotoxic. twelve subjects brushed their teeth with fresh miswak once, twice, and four times. the amount of bitc in the saliva and in the used brushes was quantified using gas c ... | 2017 | 28484501 |
| bacterial infections after pediatric heart transplantation: epidemiology, risk factors and outcomes. | bacterial infections represent a major cause of morbidity and mortality in heart transplant recipients. however, data describing the epidemiology and outcomes of these infections in children are limited. | 2017 | 28583371 |
| respiratory viral infections are underdiagnosed in patients with suspected sepsis. | the study aim was to investigate the prevalence and clinical relevance of viral findings by multiplex pcr from the nasopharynx of clinically septic patients during a winter season. during 11 weeks of the influenza epidemic period in january-march 2012, consecutive adult patients suspected to be septic (n = 432) were analyzed with cultures from blood and nasopharynx plus multiplex pcr for respiratory viruses on the nasopharyngeal specimen. the results were compared with those from microbiology an ... | 2017 | 28516200 |
| evaluation of a taqman array card for detection of central nervous system infections. | infections of the central nervous system (cns) are often acute, with significant morbidity and mortality. routine diagnosis of such infections is limited in developing countries and requires modern equipment in advanced laboratories that may be unavailable to a number of patients in sub-saharan africa. we developed a taqman array card (tac) that detects multiple pathogens simultaneously from cerebrospinal fluid. the 21-pathogen cns multiple-pathogen tac (cns-tac) assay includes two parasites (ba ... | 2017 | 28404679 |
| pediatric bacterial meningitis in japan, 2013-2015 - 3-5 years after the wide use of haemophilus influenzae type b and streptococcus pneumoniae conjugated vaccines. | haemophilus influenzae type b (hib) vaccine and pneumococcal conjugated vaccine (pcv) have been widely used since 2010 in japan when both vaccines were supported by the regional governments, and they were covered as routine recommended vaccines in 2013. the incidence of bacterial meningitis due to these organisms decreased in 2011 and 2012, but meningitis due to streptococcus agalactiae and escherichia coli remained unchanged. | 2017 | 28456490 |
| update on the epidemiology and antibiotic resistance of ocular infections. | the purpose of this review is to provide an update on the epidemiology and current antibiotic-resistant threats in ophthalmology. | 2017 | 28546690 |
| bacterial and histopathological findings in deep head and neck infections: a retrospective analysis. | deep neck infections are among the most dangerous acute diseases in the head and neck region. this analysis gives an overview of the bacterial and histopathologic findings of deep neck infections. | 2017 | 28411005 |
| progress in definition, prevention and treatment of fungal infections in cystic fibrosis. | cystic fibrosis (cf) is a chronic lethal multi-system condition; however, most of the morbidity and mortality is dependent on the status of the respiratory system. progressive respiratory decline is mediated by chronic infection and inflammation, punctuated by important acute events known as pulmonary exacerbations which can lead to accelerated decline. the main bacterial species causing infections include pseudomonas aeruginosa, staphylococcus aureus, haemophilus influenzae and achromobacter xy ... | 2017 | 28762125 |
| seasonality of acquisition of respiratory bacterial pathogens in young children with cystic fibrosis. | seasonal variations are often observed for respiratory tract infections; however, limited information is available regarding seasonal patterns of acquisition of common cystic fibrosis (cf)-related respiratory pathogens. we previously reported differential seasonal acquisition of pseudomonas aeruginosa in young children with cf and no such variation for methicillin-susceptible staphylococcus aureus acquisition. the purpose of this study was to describe and compare the seasonal incidence of acquis ... | 2017 | 28599639 |
| be aware of immunogenic but not protective antigens: the actinobacillus pleuropneumoniae pala as an example. | identification of immunogenic antigens is an important step for the vaccine improvement of infectious diseases. previous studies indicated that actinobacillus pleuropneumoniae pala is homologous to a haemophilus influenzae protective antigen hi-pal (p6) protein. however, pala protein adversely affects the apx toxin-based subunit vaccine. in this study, we confirmed that recombinant pala is immunogenic in animals. mice immunized with bacterin and pala (bacpal) showed significantly less antibodies ... | 2017 | 28828973 |
| flagellar expression in clinical isolates of non-typeable haemophilus influenzae. | haemophilus influenzae is a commensal organism found in the upper respiratory tract of humans. when h. influenzae becomes a pathogen, these bacteria can move out of their commensal niche and cause multiple respiratory tract diseases such as otitis media, sinusitis, conjunctivitis and bronchitis in children, and chronic obstructive pulmonary disease in adults. however, h. influenzae is currently considered a non-flagellate bacterium. | 2017 | 28513418 |
| alloiococcus otitidis forms multispecies biofilm with haemophilus influenzae: effects on antibiotic susceptibility and growth in adverse conditions. | otitis media with effusion (ome) is a biofilm driven disease and commonly accepted otopathogens, such as haemophilus influenzae, streptococcus pneumonia, and moraxella catarrhalis, have been demonstrated to form polymicrobial biofilms within the middle ear cleft. however, alloiococcus otitidis (a. otitidis), which is one of the most commonly found bacteria within middle ear aspirates of children with ome, has not been described to form biofilms. the aim of this study was to investigate whether a ... | 2017 | 28824879 |
| characteristics of meningitis following transsphenoidal endoscopic surgery: a case series and a systematic literature review. | meningitis occurs in 0.8-1.5% of patients undergoing neurosurgery. the aim of the study was to evaluate the characteristics of meningitis after endoscopic endonasal transsphenoidal surgery (eets) comparing the findings retrieved to those highlighted by literature search. | 2017 | 28776163 |
| implementation of the new virtuo blood culture system: evaluation and comparison to the 3d system using simulated blood cultures. | to evaluate the performances of the newly approved bact/alert virtuo blood culture system for the recovery of bloodstream pathogens and compare it to the bact/alert 3d system. | 2017 | 28583022 |
| a high seroprevalence of antibodies to pertussis toxin among japanese adults: qualitative and quantitative analyses. | in 2013, national serosurveillance detected a high seroprevalence of antibodies to pertussis toxin (pt) from bordetella pertussis among japanese adults. thus, we aimed to determine the cause(s) of this high seroprevalence, and analyzed the titers of antibodies to pt and filamentous hemagglutinin (fha) among adults (35-44 years old), young children (4-7 years old), and older children (10-14 years old). our quantitative analyses revealed that adults had higher seroprevalences of anti-pt igg and pt ... | 2017 | 28700751 |
| simultaneous detection of 13 key bacterial respiratory pathogens by combination of multiplex pcr and capillary electrophoresis. | lower respiratory tract infections continue to pose a significant threat to human health. it is important to accurately and rapidly detect respiratory bacteria. to compensate for the limits of current respiratory bacteria detection methods, we developed a combination of multiplex polymerase chain reaction (pcr) and capillary electrophoresis (mpce) assay to detect thirteen bacterial pathogens responsible for lower respiratory tract infections, including streptococcus pneumoniae, haemophilus influ ... | 2017 | 28807095 |
| transmission fitness in co-colonization and the persistence of bacterial pathogens. | humans are often colonized by polymorphic bacteria such as streptococcus pneumoniae, bordetella pertussis, staphylococcus aureus, and haemophilus influenzae. two co-colonizing pathogen clones may interact with each other upon host entry and during within-host dynamics, ranging from competition to facilitation. here we examine the significance of these exploitation strategies for bacterial spread and persistence in host populations. we model sis epidemiological dynamics to capture the global beha ... | 2017 | 28741105 |
| complete genome sequence of bordetella pertussis pelita iii, the production strain for an indonesian whole-cell pertussis vaccine. | pt bio farma, the sole world health organization-approved indonesian vaccine producer, manufactures a whole-cell whooping cough vaccine (wp) that, as part of a pentavalent diphtheria-tetanus-pertussis/hepatitis b/haemophilus influenzae b (dtp/hb/hib) vaccine, is used in indonesia and many other countries. we report here the whole-genome sequence for bordetella pertussis pelita iii, pt bio farma's wp production strain. | 2017 | 28450511 |
| immunogenicity and safety of 10-valent pneumococcal nontypeable haemophilus influenzae protein d conjugate vaccine (phid-cv) administered to children with sickle cell disease between 8 weeks and 2 years of age: a phase iii, open, controlled study. | immunogenicity, safety and reactogenicity of the 10-valent pneumococcal nontypeable haemophilus influenzae protein d conjugate vaccine (phid-cv) were evaluated in children with sickle cell disease (scd), who are at increased risk for infections. | 2017 | 28403055 |
| procalcitonin accurately identifies hospitalized children with low risk of bacterial community-acquired pneumonia. | lower procalcitonin (pct) concentrations are associated with reduced risk of bacterial community-acquired pneumonia (cap) in adults, but data in children are limited. | 2017 | 28158460 |
| the epidemiology, management, and outcomes of bacterial meningitis in infants. | the pathogens that cause bacterial meningitis in infants and their antimicrobial susceptibilities may have changed in this era of increasing antimicrobial resistance, use of conjugated vaccines, and maternal antibiotic prophylaxis for group b streptococcus (gbs). the objective was to determine the optimal empirical antibiotics for bacterial meningitis in early infancy. | 2017 | 28600447 |
| commercial essential oils as potential antimicrobials to treat skin diseases. | essential oils are one of the most notorious natural products used for medical purposes. combined with their popular use in dermatology, their availability, and the development of antimicrobial resistance, commercial essential oils are often an option for therapy. at least 90 essential oils can be identified as being recommended for dermatological use, with at least 1500 combinations. this review explores the fundamental knowledge available on the antimicrobial properties against pathogens respo ... | 2017 | 28546822 |
| determination of disk diffusion and mic quality control ranges for nafithromycin (wck 4873), a new lactone-ketolide. | disk diffusion and mic quality control (qc) ranges were determined for nafithromycin, a new lactone-ketolide, following completion of a nine-laboratory, clinical and laboratory standards institute (clsi) m23-defined tier 2 study. five qc strains consistent with the spectrum of activity of nafithromycin were tested: staphylococcus aureus atcc 25923 (disk only), s. aureus atcc 29213 (broth only), enterococcus faecalis atcc 29212 (broth only), streptococcus pneumoniae atcc 49619 (disk and broth), a ... | 2017 | 28747372 |
| a randomized, controlled study of a fully liquid dtap-ipv-hb-prp-t hexavalent vaccine for primary and booster vaccinations of healthy infants and toddlers in latin america. | hexavalent diphtheria (d)-tetanus (t)-acellular pertussis (ap)-inactivated poliovirus (ipv)-hepatitis b (hb)-haemophilus influenzae type b (prp-t)-containing vaccines are increasingly the standard of care. this study evaluated the primary series (nct01177722) and booster (nct01444781) of a fully liquid dtap-ipv-hb-prp-t vaccine in latin america. | 2017 | 28719500 |
| common bacterial isolates, clinical outcome and tb meningitis in children admitted at morogoro regional referral hospital, tanzania. | bacterial meningitis is still one of the major causes of deaths, disabilities, and mental retardation in children in morogoro region. to study the current meningitis burden, we evaluated the common bacterial isolates and clinical outcome of the disease in the region. | 2017 | 28776526 |
| prevalence and antibiotic resistance profiles of cerebrospinal fluid pathogens in children with acute bacterial meningitis in yunnan province, china, 2012-2015. | acute bacterial meningitis is still considered one of the most dangerous infectious diseases in children. to investigate the prevalence and antibiotic resistance profiles of cerebrospinal fluid (csf) pathogens in children with acute bacterial meningitis in southwest china, csf samples from 179 meningitis patients (3 days to 12 years old) with positive culture results were collected from 2012 to 2015. isolated pathogens were identified using the vitek-32 system. gram stain results were used to gu ... | 2017 | 28662145 |
| identification of a large family of slam-dependent surface lipoproteins in gram-negative bacteria. | the surfaces of many gram-negative bacteria are decorated with soluble proteins anchored to the outer membrane via an acylated n-terminus; these proteins are referred to as surface lipoproteins or slps. in neisseria meningitidis, slps such as transferrin-binding protein b (tbpb) and factor-h binding protein (fhbp) are essential for host colonization and infection because of their essential roles in iron acquisition and immune evasion, respectively. recently, we identified a family of outer membr ... | 2017 | 28620585 |
| antibiogram profile of septic meningitis among children in duhok, iraq. | to determine the prevalence of bacteria in the cerebrospinal fluid (csf), and the antibiogram profile in pediatric patients with suspected meningitis. methods: this descriptive study was conducted between january 2014 and january 2016 in the hevi paediatric teaching hospital in duhok, iraq. the csf samples were withdrawn from 432 pediatric patients suspected of meningitis. the samples were cultured, and antibiotic sensitivity tests were performed. results: there were 33 (7.6%) culture positive ... | 2017 | 28439602 |
| antimicrobial susceptibility of bacterial isolates from patients presenting with ear, nose and throat (ent) infections in the german community healthcare setting. | empiric initial antibiotic therapy of bacterial infections is based primarily upon the susceptibility of the most common causative pathogens. the purpose of this study was to provide susceptibility data on six bacterial species known to cause ear, nose and throat (ent) infections. a total of 1066 isolates collected during a nationwide laboratory-based surveillance study were analysed. all streptococcus pyogenes isolates were penicillin (pen)-susceptible, indicating that natural penicillins can s ... | 2017 | 28429163 |
| typing and characterization of bacteria using bottom-up tandem mass spectrometry proteomics. | methods for rapid and reliable microbial identification are essential in modern healthcare. the ability to detect and correctly identify pathogenic species and their resistance phenotype is necessary for accurate diagnosis and efficient treatment of infectious diseases. bottom-up tandem mass spectrometry (ms) proteomics enables rapid characterization of large parts of the expressed genes of microorganisms. however, the generated data are highly fragmented, making downstream analyses complex. her ... | 2017 | 28420677 |
| ceftaroline activity tested against bacterial isolates causing community-acquired respiratory tract infections and skin and skin structure infections in pediatric patients from united states hospitals: 2012-2014. | ceftaroline fosamil has recently received us food and drug administration approval for treatment of acute bacterial skin/skin structure infections (sssis), including those caused by methicillin-resistant staphylococcus aureus and community-acquired bacterial pneumonia for pediatric patients ≥2 months old. we evaluated the potency and spectrum of ceftaroline and comparators when tested against community-acquired respiratory tract infection (carti) and sssi pathogens from pediatric patients. a tot ... | 2017 | 28403050 |