Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| yeasts from skin colonization are able to cross the acellular dermal matrix. | in recent decades, the prognosis for burn patients has improved considerably with the development of specialized care. the acellular dermal matrix (adm) is a totally artificial acellular device that functions to control water loss, prevent penetration by bacteria and allow migration of endothelial cells and fibroblasts from patient tissues. however, little is known about its effectiveness against yeasts. the present study evaluated the capacity of colonization and migration of some human commens ... | 2018 | 29428422 |
| relative abundance ofcandida albicansandcandida glabratainin vitroco-culture biofilms impacts biofilm structure and formation. | candidais a member of the normal human microbiota and often resides on mucosal surfaces such as the oral cavity or the gastrointestinal tract. in addition to their commensality,candidaspecies can opportunistically become pathogenic if the host microbiota is disrupted or if the host immune system becomes compromised. an important factor forcandidapathogenesis is its ability to form biofilm communities. the two most medically important species -candida albicansandcandida glabrata- are often co-iso ... | 2018 | 29427422 |
| increased urine interleukin-17 and interleukin-22 levels in patients with candidal urinary tract infection. | candiduria is common in the hospitalized patients. this study aimed to quantify interleukin (il)-17 and il-22 levels in urine of candiduric patients. | 2018 | 29421775 |
| clinical characteristics of the first cases of invasive candidiasis in china due to pan-echinocandin-resistantcandida tropicalisandcandida glabrataisolates with delineation of their resistance mechanisms. | echinocandin antifungal agents have become the first-line therapy for invasive candidiasis (ic) in many countries. despite their increasing use, resistance to this class of drug is, overall, still uncommon. here, we report two patients from the people's republic of china with ic, one with infection caused by pan-echinocandin-resistantcandida tropicalisand the other by pan-echinocandin-resistantcandida glabrata. we also describe the mechanisms of drug resistance of these isolates. the echinocandi ... | 2018 | 29416360 |
| characterisation of an abc transporter of a resistant candida glabrata clinical isolate. | candida glabrata ranks second in epidemiological surveillance studies, and is considered one of the main human yeast pathogens. treatment of candida infections represents a contemporary public health problem due to the limited availability of an antifungal arsenal, toxicity effects and increasing cases of resistance. c. glabrata presents intrinsic fluconazole resistance and is a significant concern in clinical practice and in hospital environments. | 2018 | 29412345 |
| identification of medically importantcandidaspecies by polymerase chain reaction-restriction fragment length polymorphism analysis of the rdna its1 and its2 regions. | we aimed to identify the distribution of species in candidal strains isolated from clinical samples and restriction fragment length polymorphism (rflp) method based on msp i and bln i restrictive enzyme cuts of polymerase chain reaction (pcr) products after the amplification of its1 and its2 regions of rdna genotypically. | 2018 | 29405146 |
| the emerging threat of antifungal resistance in transplant infectious diseases. | the global emergence of antifungal resistance among candida spp. and aspergillus spp. will disproportionately affect transplantation recipients, who are prone to invasive fungal disease. | 2018 | 29404711 |
| candidacidal activity of a novel killer toxin from wickerhamomyces anomalus against fluconazole-susceptible and -resistant strains. | the isolation and characterization from the sand flyphlebotomus perniciosusof awickerhamomyces anomalusyeast strain (wa1f1) displaying the killer phenotype was recently reported. in the present work, the killer toxin (kt) produced bywa1f1 was purified and characterized, and its antimicrobial activity in vitro was investigated against fluconazole- susceptible and -resistant clinical isolates and laboratory strains ofcandida albicansandc. glabratadisplaying known mutations.wa1f1-kt showed a differ ... | 2018 | 29401638 |
| molecular identification of candida species from urinary infections in honduras. | candiduria is a common infection among hospitalised patients. although the clinical relevance of yeasts in urine is not clearly defined, fungal urinary tract infections have increased significantly in the last decades, becoming a growing public health problem. candida albicans is the most commonly reported species in urinary infections, although other species of the genus are becoming particularly important, because some of them are linked with resistance to antifungal drugs. | 2018 | 29395833 |
| evaluation of synergistic anticandidal and apoptotic effects of ferulic acid and caspofungin against candida albicans. | this study aimed to investigate the synergy between anticandidal and apoptotic effects of ferulic acid and caspofungin against candida albicans and candida glabrata, with the help of a quantitative checkerboard microdilution assay using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (mtt) as a viability dye. apoptotic effects of caspofungin and ferulic acid concentrations (alone and combined) were analyzed for c. albicans and c. glabrata based on annexin v-propidium iodide binding ... | 2018 | 29389586 |
| activity and expression of candida glabrata vacuolar proteases in autophagy-like conditions. | candida glabrata is an emerging opportunistic pathogen that has intrinsic resistance to azoles antifungals. during infection or while living as a commensal it encounters nutritional stresses such as deficiency of carbon or nitrogen sources. herein we investigate the expression and activity of pra, ape1, ape3 and cpy vacuolar proteases during these stressful nutrimental conditions. our findings demonstrate a differential activity profile depending on the addition or lack of carbon, nitrogen or bo ... | 2018 | 29385574 |
| fluconazole non-susceptible breakthrough candidemia after prolonged low-dose prophylaxis: a prospective funginos study. | breakthrough candidemia (btc) on fluconazole was associated with non-susceptible candida spp. and increased mortality. this nationwide funginos study analyzed clinical and mycological btc characteristics. | 2018 | 29378240 |
| reduced antifungal susceptibility of vulvovaginal candida species at normal vaginal ph levels: clinical implications. | the aims of the study were to assess for differences in antifungal in vitro potency at ph 7 and ph 4 and to discuss any potential clinical implications of that difference. | 2018 | 29474241 |
| clinical features, antimicrobial susceptibilities, and treatment outcomes of patients with culture positive endophthalmitis after penetrating keratoplasty. | to report the clinical features organisms and treatment outcomes in patients with endophthalmitis after penetrating keratoplasty (pk). | 2018 | 29468222 |
| cgpdr1 gain-of-function mutations lead to azole-resistance and increased adhesion in clinical candida glabrata strains. | recently, candida glabrata has emerged as a health-threatening pathogen and the rising resistance to antifungal agent in c. glabrata often leads to clinical treatment failure. | 2018 | 29464833 |
| remodeling of the candida glabrata cell wall in the gastrointestinal tract affects the gut microbiota and the immune response. | the gastrointestinal (gi) microbiota acts a natural barrier to the proliferation of opportunistic pathogens. candida glabrata is an opportunistic yeast pathogen that has adapted to colonize all segments of the human gi tract. we observed an increase in escherichia coli, enterococcus faecalis, and bacteroides vulgatus populations, and a decrease in lactobacillus johnsonii, bacteroides thetaiotaomicron, and bifidobacterium animalis in mice with dss-induced colitis. this reduction was more pronounc ... | 2018 | 29463799 |
| comparative virulence of candida auris with candida haemulonii, candida glabrata and candida albicans in a murine model. | the incidence of invasive fungal infections (ifis) caused by uncommon candida species with diverse virulence and susceptibility profiles has increased in recent years. due to scarce clinical and experimental data on the pathogenicity of candida auris, the aim of this study was to evaluate and compare the virulence of two rare clinically relevant species, c. auris and candida haemulonii with candida glabrata and candida albicans in an immunocompetent murine model of disseminated infection. immuno ... | 2018 | 29460345 |
| fibrin web in a patient with candida glabrata endophthalmitis. | 2018 | 29458827 | |
| multiple brain abscesses caused by infection withcandida glabrata: a case report. | the present case report described the initial diagnosis of a 25-year old female with a brain abscess consisting of two lesions 0.2 and 2.9 cm3in volume. the patient was initially treated with antibiotics; however, 2 months following initial treatment, the patient's condition deteriorated and she became vegetative. following transfer to the china-japan union hospital of jilin university (jilin, china) the two lesions had grown in volume to 9.0 and 13.0 cm3, respectively. the results of magnetic r ... | 2018 | 29456643 |
| a quest to find good primers for gene expression analysis of candida albicans from clinical samples. | biofilm production contributes to several human diseases, including oral candidiasis. among the candida species, candida albicans is the most prevalent. the expression of virulence genes is implicated in the pathogenic potential of candida biofilms. however, the evaluation of microbial gene expression from in vivo biofilm samples is not trivial, specifically, assessment via quantitative pcr (qpcr) can be a challenge because of several species present in clinical samples. hence, the necessity of ... | 2018 | 29454005 |
| detecting infections rapidly and easily for candidemia trial, part 2 (direct2): a prospective, multicenter study of the t2candida panel. | blood cultures are approximately 50% sensitive for diagnosing invasive candidiasis. the t2candida nanodiagnostic panel uses t2 magnetic resonance and a dedicated instrument to detect candida directly within whole blood samples. | 2018 | 29438475 |
| enhanced pyruvate production in candida glabrata by carrier engineering. | pyruvate is an important organic acid that plays a key role in the central metabolic pathway. manipulating transporters is an efficient strategy to enhance production of target organic acids and a means to understand the effects of altered intracellular pyruvate content on global metabolic networks. efforts have been made to manipulate mitochondrial pyruvate carrier (mpc) to transport pyruvate into different subcellular compartments in candida glabrata to demonstrate the effects of the subcellul ... | 2018 | 29044478 |
| novel naja atra cardiotoxin 1 (ctx-1) derived antimicrobial peptides with broad spectrum activity. | naja atra subsp. atra cardiotoxin 1 (ctx-1), produced by chinese cobra snakes, belonging to elapidae family, is included in the three-finger toxin family and exerts high cytotoxicity and antimicrobial activity too. using as template mainly the tip and the subsequent β-strand of the first "finger" of this toxin, different sequences of 20 amino acids linear peptides have been designed in order to avoid toxic effects but to maintain or even strengthen the partial antimicrobial activity already seen ... | 2018 | 29364903 |
| in vitroandin vivoefficacy of a novel and long acting fungicidal azole, pc1244 onaspergillus fumigatusinfection. | the antifungal effects of the novel triazole, pc1244, designed for topical or inhaled administration, againsta. fumigatushave been tested in a range ofin vitroandin vivostudies. pc1244 demonstrated potent antifungal activities against clinicala. fumigatusisolates (n=96) with a mic range of 0.016--0.25 μg/ml, whereas the mic range for voriconazole was 0.25--0.5 μg/ml. pc1244 was a strong tight-binding inhibitor of recombinanta. fumigatuscyp51a and cyp51b (sterol 14α-demethylase) enzymes and stron ... | 2018 | 29439966 |
| antimicrobial activity of a newly identified kazal-type serine proteinase inhibitor, cckpi1, from the jellyfish cyanea capillata. | in this study, we reported a jellyfish-derived kazal-type serine protease inhibitor, named cckpi1, from cyanea capillata. cckpi1 has a calculated molecular mass of 19.02kda and contains three typical kazal domains. soluble recombinant cckpi1 (rcckpi1) was successfully expressed and purified. rcckpi1 exhibited significant inhibitory activities against elastase, subtilisin a and proteinase k, but not against trypsin or chymotrypsin. kinetic studies showed that all of the inhibitory effects of rcck ... | 2018 | 29054522 |
| antifungal and antioxidant activity of fatty acid methyl esters from vegetable oils. | fatty acid methyl esters (fames) were obtained from vegetable oils of soybean, corn and sunflower. the current study was focused on evaluating the antifungal activity of fames mainly against paracoccidioides spp., as well as testing the interaction of these compounds with commercial antifungal drugs and also their antioxidant potential. fames presented small ic50 values (1.86-9.42 μg/ml). all three fames tested showed antifungal activity against isolates of paracoccidioides spp. with mic values ... | 2018 | 28876392 |
| microbial epidemiology of candidaemia in neonatal and paediatric intensive care units at the children's medical center, tehran. | invasive candidiasis is a major cause of morbidity and mortality in children. however, limited data are available on the epidemiology of this infection in paediatric settings in iran. the aim of this study was to determine the prevalence, microbial epidemiology, risk factors and clinical outcomes associated with candidaemia in intensive care units at the children's medical center, tehran, iran. all blood and other normally sterile specimen cultures positive for candida species were included. iso ... | 2018 | 28872714 |
| antifungal effect of cow's urine distillate on candida species. | increase in resistance of candida species, to routinely used antifungal agents has necessitated the quest for new drugs. few studies have revealed that cow's urine can suppress the growth of pathogenic fungi. however there is no published report on antifungal effects of cow's urine on clinical candida isolates. | 2018 | 28869083 |
| in vitro activity of micafungin against biofilms of candida albicans, candida glabrata, and candida parapsilosis at different stages of maturation. | candida spp. is able to form a biofilm, which is considered resistant to the majority of antifungals used in medicine. the aim of this study was to evaluate the in vitro activity of micafungin against candida spp. biofilms at different stages of their maturation (2, 6, and 24 h). we assessed the inhibitory effect of micafungin against 78 clinical isolates of candida spp., growing as planktonic or sessile cells, by widely recommended broth microdilution method. the in vitro effect on sessile cell ... | 2018 | 28983822 |
| enhanced pyruvate production in candida glabrata by overexpressing the cgamd1 gene to improve acid tolerance. | to enhance acid tolerance of candida glabrata for pyruvate production by engineering amp metabolism. | 2018 | 28983762 |
| genome hunting of carbonyl reductases from candida glabrata for efficient preparation of chiral secondary alcohols. | in this work, genome hunting strategy was adopted in screening for reductases from candida glabrata. a total of 37 putative reductases were successfully expressed in e. coli bl21(de3). a substrate library containing 32 substrates was established for characterization of each reductase by average specific activity and shannon-wiener index. among them, cg26 was identified with the highest efficiency and wider substrate spectrum in the reduction of prochiral ketones, with average activity and shanno ... | 2018 | 28978494 |
| vt-1161 protects mice against oropharyngeal candidiasis caused by fluconazole-susceptible and -resistant candida albicans. | candida albicans, the most common human fungal pathogen, causes chronic mucosal infections in patients with inborn errors of il-17 immunity that rely heavily on chronic, often lifelong, azole antifungal agents for treatment. however, a rise in azole resistance has predicated a need for developing new antifungal drugs. | 2018 | 29040636 |
| endoscopic endonasal transsphenoidal drainage of a spontaneous candida glabrata pituitary abscess. | noniatrogenic pituitary abscess remains a rare clinical entity, and is the indication for surgery in <1% of transsphenoidal approaches. correct diagnosis of this rare entity is often delayed. without timely treatment, morbidity and mortality are high. of the 200 cases reported to date, less than one-half have identified a causative organism. we report the second case of a pituitary abscess caused by candida species, and also provide an intraoperative video showing the endoscopic management of th ... | 2018 | 29079259 |
| high glucose-mediated overexpression of icam-1 in human vaginal epithelial cells increases adhesion of candida albicans. | to investigate the involvement of icam-1 in the adhesion of candida to the genitourinary epithelial cells in high glucose, we examined the adhesion of candida albicans or candida glabrata to human vaginal epithelial cells (vk2/e6e7) or human vulvovaginal epidermal cells (a431). these cells were cultured in 100, 500 or 3000 mg/dl glucose for three days and inoculated with candida for 60 minutes. followed by, adhering of candida to the cells, which were counted. while the adhesion of candida albic ... | 2018 | 28920516 |