Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| the evaluation of putative endogenous control housekeeping genes for real-time polymerase chain reaction expression studies in moraxella catarrhalis. | comparisons of endogenous control genes in real-time polymerase chain reaction gene expression studies involving moraxella catarrhalis are rare. this study shows that a combination of the iron sequestering gene copb and 16s rrna genes would be useful for lineage 1 (16s rrna type 1) isolates, but not lineage 2 (16s rrna types 2 and 3) isolates. | 2009 | 19717264 |
| single-residue changes in the c-terminal disulfide-bonded loop of the pseudomonas aeruginosa type iv pilin influence pilus assembly and twitching motility. | pila, the major pilin subunit of pseudomonas aeruginosa type iv pili (t4p), is a principal structural component. pila has a conserved c-terminal disulfide-bonded loop (dsl) that has been implicated as the pilus adhesinotope. structural studies have suggested that dsl is involved in intersubunit interactions within the pilus fiber. pila mutants with single-residue substitutions, insertions, or deletions in the dsl were tested for pilin stability, pilus assembly, and t4p function. mutation of eith ... | 2009 | 19717595 |
| opa+ and opa- isolates of neisseria meningitidis and neisseria gonorrhoeae induce sustained proliferative responses in human cd4+ t cells. | t cells may interact with a number of bacterial surface antigens, an encounter which has the potential to downmodulate host immune responses. neisseria meningitidis, a human colonizer and an agent of septicemia and meningitis, expresses opa proteins which interact with the ceacam1 receptor expressed on activated t cells. since ceacam1 can act as an inhibitory receptor and t cells in subepithelial tissues may encounter whole bacteria, which often express opa proteins in vivo, this study assessed ... | 2009 | 19720754 |
| molecular aspects of moraxella catarrhalis pathogenesis. | in recent years, moraxella catarrhalis has established its position as an important human mucosal pathogen, no longer being regarded as just a commensal bacterium. further, current research in the field has led to a better understanding of the molecular mechanisms involved in m. catarrhalis pathogenesis, including mechanisms associated with cellular adherence, target cell invasion, modulation of the host's immune response, and metabolism. additionally, in order to be successful in the host, m. c ... | 2009 | 19721084 |
| fulminant pertussis: a multi-center study with new insights into the clinico-pathological mechanisms. | pertussis carries a high risk of mortality in very young infants. the mechanism of refractory cardio-respiratory failure is complex and not clearly delineated. we aimed to examine the clinico-pathological features and suggest how they may be related to outcome, by multi-center review of clinical records and post-mortem findings of 10 patients with fulminant pertussis (fp). all cases were less than 8 weeks of age, and required ventilation for worsening respiratory symptoms and inotropic support f ... | 2009 | 19725100 |
| outer membrane porin m35 of moraxella catarrhalis mediates susceptibility to aminopenicillins. | the outer membrane protein m35 is a conserved porin of type 1 strains of the respiratory pathogen moraxella catarrhalis. it was previously shown that m35 is involved in the uptake of essential nutrients required for bacterial growth and for nasal colonization in mice. the aim of this study was (i) to characterize the potential roles of m35 in the host-pathogen interactions considering the known multifunctionality of porins and (ii) to characterize the degree of conservation in the phylogenetic o ... | 2009 | 19732412 |
| management of bacterial infections in children with asthma. | respiratory viruses are the single most common causes of asthma exacerbations in children. rhinovirus-induced wheezing is a risk factor for chronic asthma, but its mechanism has remained unknown. human bocavirus is a common finding in wheezing children, but its role as a respiratory pathogen is still unclear. mycoplasma pneumoniae may, like viruses, induce wheezing and asthma exacerbation. chlamydia pneumoniae and, in recent studies, chlamydia trachomatis, may not only induce asthma exacerbation ... | 2009 | 19735226 |
| elastase- and lps-exposed mice display altered responses to rhinovirus infection. | viral infection is associated with approximately one-half of acute exacerbations of chronic obstructive pulmonary disease (copd), which in turn, accelerate disease progression. in this study, we infected mice exposed to a combination of elastase and lps, a constituent of cigarette smoke and a risk factor for development of copd, with rhinovirus serotype 1b, and examined animals for viral persistence, airway resistance, lung volume, and cytokine responses. mice exposed to elastase and lps once a ... | 2009 | 19748999 |
| characterization of proteins msp22 and msp75 as vaccine antigens of moraxella catarrhalis. | moraxella catarrhalis is a respiratory tract pathogen causing otitis media in children and respiratory tract infections in adults with chronic obstructive pulmonary disease. this study examined two newly identified proteins as potential vaccine antigens. antisera raised to recombinant purified proteins msp22 and msp75 recognized corresponding native proteins in multiple strains of m. catarrhalis. vaccine formulations individually administered subcutaneously and intranasally showed enhanced clear ... | 2009 | 19786139 |
| fmt bypass in pseudomonas aeruginosa causes induction of mexxy efflux pump expression. | the intrinsic resistance of p. aeruginosa pao1 to the peptide deformylase inhibitor (pdf-i) lbm415 was mediated by the mexab-oprm and mexxy-oprm efflux pumps, the latter of which was strongly induced by lbm415. single-step exposure of pao1 deleted for mexab-oprm (therefore lacking both mexab-oprm and mexxy-oprm functions) to pdf-is selected for nfxb mutants, which express the mexcd-oprj efflux pump, indicating that these compounds are also substrates for this pump. selection of resistant mutants ... | 2009 | 19786597 |
| tonb-dependent transporters and their occurrence in cyanobacteria. | different iron transport systems evolved in gram-negative bacteria during evolution. most of the transport systems depend on outer membrane localized tonb-dependent transporters (tbdts), a periplasma-facing tonb protein and a plasma membrane localized machinery (exbbd). so far, iron chelators (siderophores), oligosaccharides and polypeptides have been identified as substrates of tbdts. for iron transport, three uptake systems are defined: the lactoferrin/transferrin binding proteins, the porphyr ... | 2009 | 19821963 |
| physiologic cold shock increases adherence of moraxella catarrhalis to and secretion of interleukin 8 in human upper respiratory tract epithelial cells. | moraxella catarrhalis, a major nasopharyngeal pathogen of the human respiratory tract, is exposed to rapid and prolonged downshifts of environmental temperature when humans breathe cold air. in the present study, we show that a 26 degrees c cold shock up-regulates the expression of uspa1, a major adhesin and putative virulence factor of m. catarrhalis, by prolonging messenger rna half-life. cold shock promotes m. catarrhalis adherence to upper respiratory tract cells via enhanced binding to fibr ... | 2009 | 19835476 |
| improved selective isolation of bordetella pertussis by use of modified cyclodextrin solid medium. | we have developed a modified cyclodextrin solid (mcs) medium using the selective antibiotic cefdinir. mcs medium exhibited higher sensitivity (95.6%; any culture-positive sample as reference) and greater inhibition of nasopharyngeal flora than did bordet-gengou agar (65.2%, p = 0.009) or cyclodextrin solid medium (39.1%, p < 0.001). | 2009 | 19846652 |
| antimicrobial susceptibility of select respiratory tract pathogens in dakar, senegal. | haemophilus influenzae, moraxella catarrhalis, streptococcus pyogenes, and streptococcus pneumoniae are the most common causative agents of respiratory tract infections (rtis). the increase in resistance to current antibacterial agents highlights the need to monitor the resistance pattern of these bacterial pathogens. | 2009 | 19858566 |
| [in vitro susceptibilities to levofloxacin and various antibacterial agents of 12,919 clinical isolates obtained from 72 centers in 2007]. | we have reported in this journal in vitro susceptibilities of clinical isolates to antibiotics every year since 1992. in this paper, we report the results of an analysis of in vitro susceptibilities of 12,919 clinical isolates from 72 centers in japan to selected antibiotics in 2007 compared with the results from previous years. the common respiratory pathogens, streptococcus pyogenes, streptococcus pneumoniae, moraxella catarrhalis and haemophilus influenzae maintained a high susceptibility to ... | 2009 | 19860322 |
| moraxella catarrhalis acquisition, airway inflammation and protease-antiprotease balance in chronic obstructive pulmonary disease. | moraxella catarrhalis causes approximately 10% of exacerbations in chronic obstructive pulmonary disease (copd) and also colonizes the lower airway in stable patients. little is known about the effects of colonization by m. catarrhalis on airway inflammation and protease-antiprotease balance, and how these changes compare to those seen during exacerbations. since copd is a progressive inflammatory disease, elucidating the effects of bacterial colonization and exacerbation on airway inflammation ... | 2009 | 19912665 |
| microbial interactions in the respiratory tract. | upper respiratory tract infections are caused by the synergistic and antagonistic interactions between upper respiratory tract viruses and 3 predominant bacterial pathogens: streptococcus pneumoniae, nontypeable haemophilus influenzae (nthi), and moraxella catarrhalis, which are members of the commensal flora of the nasopharynx. for many bacterial pathogens, colonization of host mucosal surfaces is a first and necessary step in the infectious process. s. pneumoniae and h. influenzae have intrica ... | 2009 | 19918134 |
| recent advances in otitis media. | otitis media (om) is a pervasive illness in infants and children, and many children suffer multiple episodes during the first years of life. high rates of acute otitis media (aom) are reported in developed and emerging countries. early onset is common in both settings. recurrent om is associated with several factors, including early onset of disease, having a sibling with a history of aom and absence of breast-feeding. early onset disease has been hypothesized to result from eustachian tube dysf ... | 2009 | 19918136 |
| characteristics of doripenem: a new broad-spectrum antibiotic. | doripenem (s-4661) is a new parenteral antibiotic from the carbapenem class; similarly to imipenem and meropenem, it has a broad-spectrum activity against gram-positive, gram-negative, and anaerobic bacteria. it is active against multiresistant gram-negative bacilli such as extended-spectrum beta-lactamase-producing (esbl) gram-negative enterobacteriaceae and nonfermentative gram-negative bacilli including some strains of pseudomonas aeruginosa that are resistant to other carbapenems. doripenem' ... | 2009 | 19920933 |
| chronic obstructive pulmonary disease: role of bacteria and updated guide to antibacterial selection in the older patient. | chronic obstructive pulmonary disease (copd) remains a major cause of morbidity and mortality worldwide. copd is especially prevalent in the elderly, affecting 25% of those aged>or=75 years. the course of the disease in the elderly is often complicated by co-morbid conditions, and its management is complicated by drug-drug interactions. exacerbations of copd increase rates of hospitalization and mortality and decrease quality of life. exacerbations are marked by an increase from baseline in dysp ... | 2009 | 19929027 |
| nasopharyngeal carriage of s. pneumoniae among young children in rural nepal. | to provide epidemiologic data on streptococcus pneumoniae (spn) carriage in nepal. | 2009 | 19563428 |
| hfq affects the expression of the lee pathogenicity island in enterohaemorrhagic escherichia coli. | colonization of the intestinal epithelium by enterohaemorrhagic escherichia coli (ehec) is characterized by an attaching and effacing (a/e) histopathology. the locus of enterocyte effacement (lee) pathogenicity island encodes many genes required for the a/e phenotype including the global regulator of ehec virulence gene expression, ler. the lee is subject to a complex regulatory network primarily targeting ler transcription. the rna chaperone hfq, implicated in post-transcriptional regulation, i ... | 2009 | 19570135 |
| in vitro and in vivo photodynamic therapy of otitis media in gerbils. | the aim of this study was to evaluate the antibacterial effects of photodynamic therapy (pdt) on common bacteria causing otitis media with effusion (ome). | 2009 | 19572273 |
| review of epidemiological features, microbiological diagnosis and treatment outcome of microbial keratitis: experience of over a decade. | to review the epidemiological characteristics, microbiological profile, and treatment outcome of patients with suspected microbial keratitis. | 2009 | 19574694 |
| breast-feeding is associated with a reduced frequency of acute otitis media and high serum antibody levels against nthi and outer membrane protein vaccine antigen candidate p6. | nontypeable haemophilus influenzae (nthi) causes acute otitis media (aom) in infants. breast-feeding protects against aom and/or nasopharyngeal (np) colonization; however, the mechanism of protection is incompletely understood. children with aom and healthy children were studied according to feeding status: breastfed,breast/formula fed, or formula fed. cumulative episodes of aom, elisa titers of serum igg antibodies to whole-cell nthi and vaccine candidate outer membrane protein p6, bactericidal ... | 2009 | 19581824 |
| efficacy of nasopharyngeal culture in identification of pathogen in middle ear fluid in chronic otitis media with effusion. | chronic otitis media with effusion (ome) is the leading cause of hearing loss during childhood. in bacterial etiology of ome, the most frequent pathogens responsible are haemophilus influenzae followed by streptococcus pneumoniae and moraxella catarrhalis. this study aimed at evaluating the accuracy of nasopharyngeal (np) specimens in the identification of pathogens in the middle ear fluid (mef) in patients with ome. | 2009 | 19584505 |
| bsac standardized disc susceptibility testing method (version 8). | there have been considerable changes to the format of the recommendations since the previous version (version 7). the majority of the footnotes to the tables have been removed and the notations added to the end column; it is hoped that this change will avoid confusion in interpretation. antibiotics have been separated into groups, e.g. beta-lactams, aminoglycosides, etc. recommendations for urinary tract infections (utis) have been removed for most agents except for those that are administered s ... | 2009 | 19587067 |
| in vivo characterization of the peptide deformylase inhibitor lbm415 in murine infection models. | lbm415 is an antibacterial agent belonging to the peptide deformylase inhibitor class of compounds. it has previously been shown to demonstrate good activity in vitro against a range of pathogens. in this study, the in vivo efficacy of lbm415 was evaluated in various mouse infection models. we investigated activity against a systemic infection model caused by intraperitoneal inoculation of staphylococcus aureus (methicillin [meticillin] susceptible [mssa] and methicillin resistant [mrsa]) and st ... | 2009 | 19596876 |
| cefditoren versus community-acquired respiratory pathogens: time-kill studies. | the time-kill method was used to determine the bactericidal activity of cefditoren compared with oral cephalosporins, amoxicillin, amoxicillin/clavulanate and levofloxacin against a randomly selected group of strains isolated from community-acquired respiratory tract infections (cartis). cefditoren was the only agent showing significant bactericidal activity (>or=3 log(10 )reduction of viable cells) within 4 h against all streptococcus pneumoniae strains, both penicillin-susceptible (pen s) or - ... | 2009 | 19622454 |
| in vitro activity and in vivo efficacy of clavulanic acid against acinetobacter baumannii. | clavulanic acid (cla) exhibits low mics against some acinetobacter baumannii strains. the present study evaluates the efficacy of cla in a murine model of a. baumannii pneumonia. for this purpose, two clinical strains, ab11 and ab51, were used; cla mics for these strains were 2 and 4 mg/liter, respectively, and the imipenem (ipm) mic was 0.5 mg/liter for both. a pneumonia model in c57bl/6 mice was used. the cla dosage (13 mg/kg of body weight given intraperitoneally) was chosen to reach a maximu ... | 2009 | 19635957 |
| molecular characterization of capnocytophaga canimorsus and other canine capnocytophaga spp. and assessment by pcr of their frequencies in dogs. | capnocytophaga canimorsus can be a virulent pathogen, whereas c. cynodegmi is of low virulence. heterogeneity within these species, their frequency in dogs, and pathogenicity factors are largely unknown. strains from blood cultures from patients presumptively identified as c. canimorsus (n = 25) and as c. cynodegmi by rrs analysis (n = 4), blood cultures from dogs (n = 8), blood cultures from cats (n = 2), and cultures from swabs from dog mouths (n = 53) were analyzed. pcr-restriction fragment l ... | 2009 | 19641058 |
| rapid real-time pcr assays for detection of klebsiella pneumoniae with the rmpa or maga genes associated with the hypermucoviscosity phenotype: screening of nonhuman primates. | the relationship of mucoviscosity-associated (maga) and/or regulator of mucoid phenotype (rmpa) genes to the klebsiella pneumoniae hypermucoviscosity (hmv) phenotype has been reported. we previously demonstrated that rmpa+ k. pneumoniae can cause serious disease in african green monkeys and isolated rmpa+ and maga+ hmv k. pneumoniae from other species of non-human primates. to rapidly screen african green monkeys/non-human primates for these infections, we developed three real-time pcr assays. t ... | 2009 | 19644019 |
| use of moraxella catarrhalis lipooligosaccharide mutants to identify specific oligosaccharide epitopes recognized by human serum antibodies. | moraxella catarrhalis is a causative agent of otitis media in children and lower respiratory tract infections in adults suffering from chronic obstructive pulmonary disease (copd). this strict human pathogen continues to be a significant cause of disease in this broad spectrum of patients because there is no available vaccine. although numerous putative vaccine antigens have been described, little is known about the human immune response to m. catarrhalis infection in vivo. human serum antibodie ... | 2009 | 19651870 |
| hag mediates adherence of moraxella catarrhalis to ciliated human airway cells. | moraxella catarrhalis is a human pathogen causing otitis media in infants and respiratory infections in adults, particularly patients with chronic obstructive pulmonary disease. the surface protein hag (also designated mid) has previously been shown to be a key adherence factor for several epithelial cell lines relevant to pathogenesis by m. catarrhalis, including ncih292 lung cells, middle ear cells, and a549 type ii pneumocytes. in this study, we demonstrate that hag mediates adherence to air- ... | 2009 | 19667048 |
| commentary. on the epidemiology of influenza: reply to radonovich et al. | on the epidemiology of influenza: reply to radonovich lj, martinello ra, hodgson m, milton dk, nardell ea. influenza and ultraviolet germicidal irradiation. virol j. 2008, 5:149. | 2009 | 19671177 |
| [antimicrobial susceptibility surveillance of recent isolates from otorhinolaryngological infections to garenoxacin and other antimicrobial drugs]. | the antimicrobial susceptibility of 339 isolates from the otorhinolaryngological infections at the otorhinolaryngological departments at 27 universities in japan, as well as their 108 affiliated hospitals and practitioners during january 2007 to june 2007 was determined to garenoxacin (grnx), levofloxacin, moxifloxacin, azithromycin, cefditoren, and cefcapene applicable for otorhinolaryngological infections. the in vitro activities of these drugs against the isolates were compared. the quinolone ... | 2009 | 19673349 |
| [drug susceptibility of bacteria isolated from pediatric respiratory infections at general practitioners' clinics to pediatric antibiotics]. | four major causative bacteria (streptococcus pneumoniae, haemophilus influenzae, moraxella catarrhalis, streptococcus pyogenes) of pediatric respiratory infections, 295 clinical isolates in total, were isolated at general practitioners' clinics in sendai city, and evaluated the drug susceptibility to seven antibiotics for pediatric. penicillin-resistant s. pneumoniae and penicillin-intermediate s. pneumoniae (prsp-pisp) were 55.8% of all s. pneumoniae isolates. the mic90 of penicillin and cephal ... | 2009 | 19673351 |
| [clinical efficacy, safety and pk-pd analysis of tebipenem pivoxil in a phase ii clinical trial in otolaryngological infections]. | we conducted a double-blind intergroup comparative study investigating the efficacy, safety and pk-pd analysis of the new oral carbapenem antibacterial drug tebipenem pivoxil (tbpm-pi) for the treatment of otolaryngological infections in adults to establish the recommended clinical dosage. the primary endpoint was the clinical effect of a 7-day oral administration of tbpm-pi to subjects with confirmed cases of infection by any of the 5 major bacterial species causative for otolaryngological infe ... | 2009 | 19673357 |
| streptococcus pneumoniae dna load in blood as a marker of infection in patients with community-acquired pneumonia. | direct detection of streptococcus pneumoniae dna in blood adds to culture results in the etiological diagnosis of patients with community-acquired pneumonia (cap). quantification of the amount of dna, the bacterial dna load (bdl), provides a measurement of dnaemia that may increase the understanding of the clinical relevance of s. pneumoniae dna in blood. we evaluated the s. pneumoniae bdl as a diagnostic tool in adult patients with cap. the bdl was determined in whole-blood samples collected si ... | 2009 | 19675218 |
| antibacterial activities of a fosfomycin/tobramycin combination: a novel inhaled antibiotic for bronchiectasis. | to compare the in vitro and in vivo activities of a 4:1 (w/w) fosfomycin/tobramycin combination (fti) with those of fosfomycin and tobramycin alone against cystic fibrosis (cf) and non-cf bronchiectasis pathogens. | 2009 | 19679597 |
| the effects of treatment of acute otitis media with a low dose vs a high dose of amoxicillin on the nasopharyngeal flora. | to compare the effects on the nasopharyngeal flora of therapy of acute otitis media in children with either a low dose or a high dose of amoxicillin. | 2009 | 19451466 |
| development of a disk diffusion method for testing moraxella catarrhalis susceptibility using clinical and laboratory standards institute methods: a sentry antimicrobial surveillance program report. | currently, there is no clinical and laboratory standards institute (clsi) disk diffusion method for testing moraxella catarrhalis susceptibility. we examined 318 clinical strains of m. catarrhalis obtained as part of the sentry (asia-pacific) antimicrobial surveillance program, plus two atcc strains. mics were determined by the clsi standard broth microdilution method, and zone diameters were determined on mueller-hinton agar incubated in 5% co(2). all strains were examined for the presence of b ... | 2009 | 19458179 |
| lysyl oxidase (lox) gene deficiency affects osteoblastic phenotype. | lysyl oxidase (lox) catalyzes cross-linking of elastin and collagen, which is essential for the structural integrity and function of bone tissue. the present study examined the role of lox gene deficiency for the osteoblast phenotype in primary calvarial osteoblasts from e18.5 lox knockout (lox ( -/- )) and wild type (wt) (c57bl/6) mice. next to lox gene depletion, mrna expression of lox isoforms, loxl1-4, was significantly downregulated in lox ( -/- ) bone tissue. a significant decrease of dna ... | 2009 | 19458888 |
| opns, an outer membrane porin of xenorhabdus nematophila, confers a competitive advantage for growth in the insect host. | the gammaproteobacterium xenorhabdus nematophila engages in a mutualistic association with an entomopathogenic nematode and also functions as a pathogen toward different insect hosts. we studied the role of the growth-phase-regulated outer membrane protein opns in host interactions. opns was shown to be a 16-stranded beta-barrel porin. opns was expressed during growth in insect hemolymph and expression was elevated as the cell density increased. when wild-type and opns deletion strains were coin ... | 2009 | 19465651 |
| complement evasion strategies of pathogens-acquisition of inhibitors and beyond. | activation of the complement system and resulting opsonisation with c3b are key events of the innate immune defense against infections. however, a wide variety of bacterial pathogens subvert complement attack by binding host complement inhibitors such as c4b-binding protein, factor h and vitronectin, which results in diminished opsonophagocytosis and killing of bacteria by lysis. another widely used strategy is production of proteases, which can effectively degrade crucial complement components. ... | 2009 | 19477524 |
| moraxella catarrhalis, a human respiratory tract pathogen. | moraxella catarrhalis is an exclusively human pathogen and is a common cause of otitis media in infants and children, causing 15%-20% of acute otitis media episodes. m. catarrhalis causes an estimated 2-4 million exacerbations of chronic obstructive pulmonary disease in adults annually in the united states. m. catarrhalis resembles commensal neisseria species in culture and, thus, may be overlooked in samples from the human respiratory tract. the prevalence of colonization of the upper respirato ... | 2009 | 19480579 |
| new vaccines against otitis media: projected benefits and cost-effectiveness. | new vaccines that offer protection against otitis media caused by nontypeable haemophilus influenzae and by moraxella catarrhalis are under development. however, the potential health benefits and economic effects of such candidate vaccines have not been systematically assessed. | 2009 | 19482754 |
| vaccine development for moraxella catarrhalis: rationale, approaches and challenges. | 2009 | 19485745 | |
| severe cytomegalovirus (cmv) community-acquired pneumonia (cap) in a nonimmunocompromised host. | community-acquired pneumonia (cap) in an immunocompetent host may be severe because of a variety or combination of host and microbial factors. in patients with severe cardiopulmonary dysfunction, even relatively avirulent pathogens, that is, mycoplasma pneumoniae, moraxella catarrhalis, may compromise borderline cardiac/heart function and present clinically as severe cap. alternately, patients with streptococcus pneumoniae and impaired humoral immunity/splenic dysfunction may present as severe c ... | 2009 | 19486794 |
| afn-1252, a fabi inhibitor, demonstrates a staphylococcus-specific spectrum of activity. | afn-1252, a potent inhibitor of enoyl-acyl carrier protein reductase (fabi), inhibited all clinical isolates of staphylococcus aureus (n = 502) and staphylococcus epidermidis (n = 51) tested, including methicillin (meticillin)-resistant isolates, at concentrations of <or=0.12 microg/ml. in contrast, afn-1252 was inactive (mic(90), >4 microg/ml) against clinical isolates of streptococcus pneumoniae, beta-hemolytic streptococci, enterococcus spp., enterobacteriaceae, nonfermentative gram-negative ... | 2009 | 19487444 |
| mycophenolate mofetil: effects on cellular immune subsets, infectious complications, and antimicrobial activity. | mycophenolate mofetil (mmf) is one of the most frequently used immunosuppressive drugs in solid organ transplant recipients. mmf is an inhibitor of inosine-5'-monophosphate, and is able to preferentially inhibit b-cell and t-cell function. the immunosuppressive abilities of mmf have made it one of the most successful anti-rejection drugs in transplant patients, but patients also appear to have increased susceptibility to infections, specifically cytomegalovirus and bk virus. despite its associat ... | 2009 | 19497072 |
| respiratory syncytial virus-induced dysregulation of expression of a mucosal beta-defensin augments colonization of the upper airway by non-typeable haemophilus influenzae. | otitis media (om) is a polymicrobial disease wherein upper respiratory tract viruses compromise host airway defences, which allows bacterial flora of the nasopharynx (np) access to the middle ear. we have shown, in vitro, that respiratory syncytial virus (rsv), a viral co-pathogen of om, reduces transcript abundance of the antimicrobial peptide (ap), chinchilla beta-defensin-1 (cbd-1). here, we demonstrated that chinchillas inoculated with rsv expressed approximately 40% less cbd-1 mrna and prot ... | 2009 | 19500108 |
| potential contribution by nontypable haemophilus influenzae in protracted and recurrent acute otitis media. | characterization of acute otitis media (aom) caused by nontypable haemophilus influenzae (nthi) is important, particularly in view of the efforts to develop vaccines against nthi. to characterize nthi aom a large database of culture-positive aom cases was analyzed. | 2009 | 19504729 |
| [evaluation of effectiveness and tolerance of treatment with azithromycin 1.5% eye drops in bacterial conjunctivitis]. | azithromycin is a macrolide class antibiotic, recently adapted for topical use in ophthalmology. it is effective against the most frequent pathogens found in bacterial conjunctivitis, gram positive and gram negative bacteria. azithromycin has the specificity to have sustained high tissue levels: after repeated instillation, it has been shown to reach sustained concentrations above the mics of susceptible bacteria for 4 days in tears and for 7 days in conjunctiva. | 2009 | 19517846 |
| identification of adenoid biofilms with middle ear pathogens in otitis-prone children utilizing sem and fish. | biofilms have been implicated in the development of several chronic infections. we sought to demonstrate middle ear pathogens in adenoid biofilms using scanning electron microscopy (sem) and fluorescent in situ hybridization (fish) with confocal laser scanning microscopy (clsm). | 2009 | 19525016 |
| transcriptional profiling identifies the metabolic phenotype of gonococcal biofilms. | neisseria gonorrhoeae, the etiologic agent of gonorrhea, is frequently asymptomatic in women, often leading to chronic infections. one factor contributing to this may be biofilm formation. n. gonorrhoeae can form biofilms on glass and plastic surfaces. there is also evidence that biofilm formation may occur during natural cervical infection. to further study the mechanism of gonococcal biofilm formation, we compared transcriptional profiles of n. gonorrhoeae biofilms to planktonic profiles. biof ... | 2009 | 19528210 |
| new semiphysiological absorption model to assess the pharmacodynamic profile of cefuroxime axetil using nonparametric and parametric population pharmacokinetics. | cefuroxime axetil is widely used to treat respiratory tract infections. we are not aware of a population pharmacokinetic (pk) model for cefuroxime axetil. our objectives were to develop a semiphysiological population pk model and evaluate the pharmacodynamic profile for cefuroxime axetil. twenty-four healthy volunteers received 250 mg oral cefuroxime as a suspension after a standardized breakfast. liquid chromatography-tandem mass spectrometry was used for drug analysis, nonmem and s-adapt (resu ... | 2009 | 19528278 |
| in vitro activity of tr-700, the active ingredient of the antibacterial prodrug tr-701, a novel oxazolidinone antibacterial agent. | tr-701 is the prodrug of the microbiologically active molecule tr-700, a novel orally and intravenously administered oxazolidinone antibacterial agent. the in vitro activity of tr-700 was evaluated against 1,063 bacterial clinical isolates including staphylococci, enterococci, streptococci, moraxella catarrhalis, haemophilus influenzae, and a variety of anaerobic bacterial species. the test strains were recent (2005 to 2008) clinical isolates from diverse u.s. (80%) and non-u.s. (20%) sites. mic ... | 2009 | 19528279 |
| in vitro and in vivo properties of dihydrophthalazine antifolates, a novel family of antibacterial drugs. | racemic 2,4-diaminopyrimidine dihydrophthalazine derivatives bal0030543, bal0030544, and bal0030545 exhibited low in vitro mics toward small, selected panels of enterococcus faecalis, enterococcus faecium, streptococcus pneumoniae, moraxella catarrhalis, and mycobacterium avium, though the compounds were less active against haemophilus influenzae. the constellation of dihydrofolate reductases (dhfrs) present in 20 enterococci and 40 staphylococci was analyzed and correlated with the antibacteria ... | 2009 | 19546364 |
| antibacterial activity of helleborus bocconei ten. subsp. siculus root extracts. | roots of helleborus bocconei ten. subsp. siculus (schiffner) merxm. & podl. are widely used in veterinary folk medicine in sicily (italy) to diagnose and cure lower respiratory tract infections in cattle. this study intended to evaluate the in vitro antibacterial activity of the methanolic root extract of helleborus bocconei ten. subsp. siculus, and of the bufadienolide and ecdysteroid fractions extracted from its roots, against strains belonging to species commonly associated with respiratory t ... | 2009 | 19549565 |
| nationwide surveillance of bacterial respiratory pathogens conducted by the japanese society of chemotherapy in 2007: general view of the pathogens' antibacterial susceptibility. | for the purpose of a nationwide surveillance of the antimicrobial susceptibility of bacterial respiratory pathogens in patients in japan, the japanese society of chemotherapy conducted their second year survey, during the period from january to august, 2007. a total of 1178 strains were collected from clinical specimens obtained from adult patients with well-diagnosed respiratory tract infections. susceptibility testing was evaluable for 1108 strains (226 staphylococcus aureus, 257 streptococcus ... | 2009 | 19554400 |
| the acinetobacter baylyi hfq gene encodes a large protein with an unusual c terminus. | in gammaproteobacteria the hfq protein shows a great variation in size, especially in its c-terminal part. extremely large hfq proteins consisting of almost 200 amino acid residues and more are found within the gammaproteobacterial family moraxellaceae. the difference in size compared to other hfq proteins is due to a glycine-rich domain near the c-terminal end of the protein. acinetobacter baylyi, a nonpathogenic soil bacterium and member of the moraxellaceae encodes a large 174-amino-acid hfq ... | 2009 | 19561130 |
| immunoglobulin d enhances immune surveillance by activating antimicrobial, proinflammatory and b cell-stimulating programs in basophils. | immunoglobulin d (igd) is an enigmatic antibody isotype that mature b cells express together with igm through alternative rna splicing. here we report active t cell-dependent and t cell-independent igm-to-igd class switching in b cells of the human upper respiratory mucosa. this process required activation-induced cytidine deaminase (aid) and generated local and circulating igd-producing plasmablasts reactive to respiratory bacteria. circulating igd bound to basophils through a calcium-mobilizin ... | 2009 | 19561614 |
| role of hrpa in biofilm formation of neisseria meningitidis and regulation of the hrpbas transcripts. | two-partner secretion systems of gram-negative organisms are utilized in adherence, invasion, and biofilm formation. the hrpab proteins of neisseria meningitidis are members of a two-partner secretion system, and hrpa is established as being important to adherence and intracellular escape. this study set out to determine the expression pattern of members of the hrpbas putative operon and to find a functional role for the hrpa protein. the upregulation of these genes was found in situations of an ... | 2009 | 19289515 |
| novel ureas and thioureas of 15-membered azalides with antibacterial activity against key respiratory pathogens. | the new ureas and thioureas of 15-membered azalides, n''-substituted 9a-(n'-carbamoyl-gamma-aminopropyl) (4), 9a-(n'-thiocarbamoyl-gamma-aminopropyl) (6), 9a-[n'-(beta-cyanoethyl)-n'-(carbamoyl-gamma-aminopropyl)] (8) and 9a-[n'-(beta-cyanoethyl)-n'-(thiocarbamoyl-gamma-aminopropyl)] (10) of 9-deoxo-9-dihydro-9a-aza-9a-homoerythromycin a (2), were synthesized and structurally characterized by nmr and ir spectroscopic methods and mass spectrometry. the new compounds were evaluated in vitro agains ... | 2009 | 19303171 |
| the incidence of streptococcus pneumoniae otitis media is affected by the polymicrobial environment particularly moraxella catarrhalis in a mouse nasal colonisation model. | otitis media (om) is a highly prevalent paediatric disease with both bacterial and viral triggers of infection. this study has investigated how combinations of bacteria associated with nasal colonisation and the occurrence and absence of viral infection (sendai virus) induce om in a mouse nasal colonisation model. the respiratory virus significantly contributed to bacterial om for all bacterial combinations (p<0.001). streptococcus pneumoniae consistently dominated as the causative bacterium of ... | 2009 | 19306940 |
| comparative antipneumococcal activities of sulopenem and other drugs. | for 297 penicillin-susceptible, -intermediate, and -resistant pneumococcal strains, the sulopenem mic(50)s were 0.008, 0.06, and 0.25, respectively, and the sulopenem mic(90)s were 0.016, 0.25, and 0.5 microg/ml, respectively. the mic(50)s of amoxicillin for the corresponding strains were 0.03, 0.25, and 2.0 microg/ml, respectively, and the mic(90)s were 0.03, 1.0, and 8.0 microg/ml, respectively. the combination of amoxicillin and clavulanate gave mics similar to those obtained with amoxicillin ... | 2009 | 19307366 |
| epidemiologic and microbiologic characteristics of culture-positive spontaneous otorrhea in children with acute otitis media. | we aimed to describe the epidemiologic and microbiologic characteristics of acute otitis media (aom) with spontaneous otorrhea in children and compare it with aom with intact tympanic membrane in children who underwent tympanocentesis. | 2009 | 19319018 |
| update of cefditoren activity tested against community-acquired pathogens associated with infections of the respiratory tract and skin and skin structures, including recent pharmacodynamic considerations. | antimicrobial resistance rates have noticeably increased among commonly isolated species associated with respiratory tract infections and skin and skin structure infections, particularly streptococcus pneumoniae and staphylococcus aureus. cefditoren, an oral 3rd-generation-like cephalosporin, has been shown to be very active against many gram-positive and gram-negative species with favorable attributes including bactericidal activity and stability against many beta-lactamase enzymes. clinical tr ... | 2009 | 19321284 |
| identification of domains of the hag/mid surface protein recognized by systemic and mucosal antibodies in adults with chronic obstructive pulmonary disease following clearance of moraxella catarrhalis. | moraxella catarrhalis is a common cause of respiratory tract infection in the setting of chronic obstructive pulmonary disease (copd). adults with copd acquire and clear strains of m. catarrhalis from the respiratory tract continuously and develop strain-specific protection following clearance of a strain. in previous work, we identified hag/mid (moraxella immunoglobulin d-binding protein), a large multifunctional surface protein that acts as an adhesin and hemagglutinin, as a target of antibody ... | 2009 | 19321697 |
| superantigen- and tlr-dependent activation of tonsillar b cells after receptor-mediated endocytosis. | classical b lymphocyte activation is dependent on bcr cross-linking in combination with physical interaction with th cells. other b cell molecules that contribute to the activation are complement, cytokine, and tlrs recognizing specific pathogen-associated molecular patterns. moraxella (branhamella) catarrhalis is a common gram-negative respiratory pathogen that induces proliferation in human igd-expressing b cells independently of t cell help. the activation is initiated by the b cell superanti ... | 2009 | 19342647 |
| molecular characterization and identification of proteins regulated by hfq in neisseria meningitidis. | hfq is a highly conserved pleiotropically acting prokaryotic rna-binding protein involved in the post-transcriptional regulation of many stress-responsive genes by small rnas. in this study, we show that hfq of the strictly human pathogen neisseria meningitidis is involved in the regulation of expression of components involved in general metabolic pathways, iron metabolism and virulence. a meningococcal hfq deletion strain (h44/76deltahfq) is impaired in growth in nutrient-rich media and does no ... | 2009 | 19374669 |
| detection of streptococcus pneumoniae strain cocolonization in the nasopharynx. | colonization with more than one distinct strain of the same species, also termed cocolonization, is a prerequisite for horizontal gene transfer between pneumococcal strains that may lead to change of the capsular serotype. capsule switch has become an important issue since the introduction of conjugated pneumococcal polysaccharide vaccines. there is, however, a lack of techniques to detect multiple colonization by s. pneumoniae strains directly in nasopharyngeal samples. two hundred eighty-seven ... | 2009 | 19386843 |
| comparison of in vitro activities of tigecycline with other antimicrobial agents against streptococcus pneumoniae, haemophilus influenzae and moraxella catarrhalis in two university hospitals in istanbul, turkey. | we compared the in vitro activities of tigecycline with those of other agents against 97 streptococcus pneumoniae, 140 haemophilus influenzae and 54 moraxella catarrhalis strains isolated in two large university hospitals in istanbul. | 2009 | 19390189 |
| phasevarions mediate random switching of gene expression in pathogenic neisseria. | many host-adapted bacterial pathogens contain dna methyltransferases (mod genes) that are subject to phase-variable expression (high-frequency reversible on/off switching of gene expression). in haemophilus influenzae, the random switching of the moda gene controls expression of a phase-variable regulon of genes (a "phasevarion"), via differential methylation of the genome in the moda on and off states. phase-variable mod genes are also present in neisseria meningitidis and neisseria gonorrhoeae ... | 2009 | 19390608 |
| evaluation of five commercial real-time pcr assays for detection of mycoplasma pneumoniae in respiratory tract specimens. | the performances of five commercial taqman real-time pcr assays for the detection of mycoplasma pneumoniae in respiratory tract specimens were evaluated in comparison with an in-house real-time pcr. all kits allowed prompt and specific results, validated by the use of an internal control. the nanogen kit showed the best clinical sensitivity. | 2009 | 19403761 |
| virulence mechanisms of moraxella in the pathogenesis of infection. | moraxella catarrhalis is an emerging human-specific pathogen responsible for upper and lower respiratory tract infections. understanding the events in the complex pathogenesis and underlying mechanisms during m. catarrhalis infection is a key to the development of novel therapeutics and vaccines. | 2009 | 19405217 |
| streptococcus pneumoniae and haemophilus influenzae at the initial stage of influenza. | streptococcus pneumoniae and haemophilus influenzae infections in children with influenza have been noted because of the severity of co-infection. in japan, vaccination against s. pneumoniae and h. influenzae infections has been listed in the vaccine program in 2008, but the characteristics of the two organisms, colonizing at the initial stage of influenza infection, have not been investigated in detail. | 2009 | 19419515 |
| evaluation of the oxoid xpect legionella test kit for detection of legionella pneumophila serogroup 1 antigen in urine. | we evaluated a new immunochromatographic assay (oxoid xpect legionella test kit) for the ability to detect legionella pneumophila serogroup 1 antigen in urine. the results were compared with those obtained with the binax now urinary antigen test by following the manufacturers' instructions. the sensitivities and specificities were estimated to be 89 and 100%, respectively, for the oxoid xpect legionella test kit and 86 and 100%, respectively, for the binax now test. | 2009 | 19420163 |
| identification of genes contributing to the virulence of francisella tularensis schu s4 in a mouse intradermal infection model. | francisella tularensis is a highly virulent human pathogen. the most virulent strains belong to subspecies tularensis and these strains cause a sometimes fatal disease. despite an intense recent research effort, there is very limited information available that explains the unique features of subspecies tularensis strains that distinguish them from other f. tularensis strains and that explain their high virulence. here we report the use of targeted mutagenesis to investigate the roles of various ... | 2009 | 19424499 |
| radical scavenging activity of the essential oil of silver fir (abies alba). | the essential oil of silver fir (abies alba) is known to help respiratory system and have easing and soothing effect for muscle. in the present study, we investigated the chemical composition, cytotoxicity and its biological activities of silver fir (abies alba) essential oil. the composition of the oil was analyzed by gc-ms and bornyl acetate (30.31%), camphene (19.81%), 3-carene (13.85%), tricyclene (12.90%), dl-limonene (7.50%), alpha-pinene (2.87%), caryophyllene (2.18%), beta-phellandrene ( ... | 2009 | 19430614 |
| resistance selection studies comparing the activity of razupenem (ptz601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible staphylococcus aureus strains. | multistep and single-step resistance selection studies were performed with razupenem, linezolid, and vancomycin against 10 methicillin (meticillin)-resistant and -susceptible staphylococcus aureus strains. after 20 daily subcultures, razupenem yielded only clones with mics of >4 microg/ml in one strain (8 microg/ml) whose parent's mic was already 4 microg/ml. after 18 to 49 passages in 6/10 strains, razupenem mics rose from 0.016 to 2 microg/ml (parents) to 0.125 to 8 microg/ml (with clones stab ... | 2009 | 19433566 |
| topical retapamulin in the management of infected traumatic skin lesions. | retapamulin is a novel semisynthetic pleuromutilin antibiotic specifically designed for use as a topical agent. the unique mode of action by which retapamulin selectively inhibits bacterial protein synthesis differentiates it from other nonpleuromutilin antibacterial agents that target the ribosome or ribosomal factors, minimizing the potential for target-specific cross-resistance with other antibacterial classes in current use. in vitro studies show that retapamulin has high potency against the ... | 2009 | 19436611 |
| molecular epidemiological study of moraxella catarrhalis isolated from nosocomial respiratory infection patients in a community hospital in japan. | moraxella catarrhalis, occasionally, plays the essential role in nosocomial respiratory infection (nri). few studies have reported the route by which this organism spreads in a nosocomial infection outbreak. we identified characteristics of the strains isolated from nri and attempted to reveal the potential nosocomial transmission routes. | 2009 | 19443974 |
| pneumococcal vaccination and otitis media in australian aboriginal infants: comparison of two birth cohorts before and after introduction of vaccination. | aboriginal children in remote australia have high rates of complicated middle ear disease associated with streptococcus pneumoniae and other pathogens. we assessed the effectiveness of pneumococcal vaccination for prevention of otitis media in this setting. | 2009 | 19228431 |
| binding of faropenem and other beta-lactam agents to penicillin-binding proteins of pneumococci with various beta-lactam susceptibilities. | faropenem demonstrated low mics (< or = 1 microg/ml) for all penicillin-susceptible and nonsusceptible pneumococci and exhibited very strong abilities to bind to streptococcus pneumoniae penicillin-binding proteins (pbps), except for pbp2x. the lower faropenem affinity for pbp2x did not affect mics for any strains tested, and only imipenem had lower mics, with much lower binding affinities for all pbps tested, than faropenem. | 2009 | 19237649 |
| moraxella catarrhalis pneumonia in an aids patient: a case report. | moraxella catarrhalis pneumonia, although in the immunocompromised patients is very uncommon for community-acquired pneumonia (cap). it demonstrates a potential pathogen with high mortality when the presence of heavy numbers of organisms, intracellularly and extracellularly, in the sputum gram's stained smears confirmed by cultures. in 2007, the authors reported a case of a 28-year-old thai single male patient with acquired-immunodeficiency syndrome (aids) and moraxella catarrhalis pneumonia who ... | 2009 | 19253807 |
| comparative in vitro susceptibilities of human mycoplasmas and ureaplasmas to a new investigational ketolide, cem-101. | mics were determined for an investigational ketolide, cem-101, and azithromycin, telithromycin, doxycycline, levofloxacin, clindamycin, and linezolid against 36 mycoplasma pneumoniae, 5 mycoplasma genitalium, 13 mycoplasma hominis, 15 mycoplasma fermentans, and 20 ureaplasma isolates. all isolates, including two macrolide-resistant m. pneumoniae isolates, were inhibited by cem-101 at < or = 0.5 microg/ml, making cem-101 the most potent compound tested. | 2009 | 19258276 |
| evaluation of a rapid immunochromatographic odk0501 assay for detecting streptococcus pneumoniae antigen in sputum samples from patients with lower respiratory tract infection. | a novel, rapid, and noninvasive test (odk0501) to detect streptococcus pneumoniae antigen was evaluated in a japanese multicenter study. odk0501 uses polyclonal antibodies to detect c polysaccharide of s. pneumoniae from sputum samples by an immunochromatographic assay. the utility of odk0501 was evaluated for 161 adult patients with lower respiratory tract infection between march 2006 and march 2007. bacterial culture and identification, real-time pcr, and odk0501 assays were performed on sputu ... | 2009 | 19261775 |
| mouse models for human otitis media. | otitis media (om) remains the most common childhood disease and its annual costs exceed $5 billion. its potential for permanent hearing impairment also emphasizes the need to better understand and manage this disease. the pathogenesis of om is multifactorial and includes infectious pathogens, anatomy, immunologic status, genetic predisposition, and environment. recent progress in mouse model development is helping to elucidate the respective roles of these factors and to significantly contribute ... | 2009 | 19272362 |
| time for first antibiotic dose is not predictive for the early clinical failure of moderate-severe community-acquired pneumonia. | the time to first antibiotic dose (tfad) has been mentioned as an important performance indicator in community-acquired pneumonia (cap). however, the advice to minimise tfad to 4 hours (4 h) is only based on database studies. we prospectively studied the effect of minimising the tfad on the early clinical outcome of moderate-severe cap. on admission, patients' medical data and tfad were recorded. early clinical failure was expressed as the proportion of patients with clinical instability, admiss ... | 2009 | 19280235 |
| sideromycins: tools and antibiotics. | sideromycins are antibiotics covalently linked to siderophores. they are actively transported into gram-positive and gram-negative bacteria. energy-coupled transport across the outer membrane and the cytoplasmic membrane strongly increases their antibiotic efficiency; their minimal inhibitory concentration is at least 100-fold lower than that of antibiotics that enter cells by diffusion. this is particularly relevant for gram-negative bacteria because the outer membrane, which usually forms a pe ... | 2009 | 19130258 |
| in vitro activity of iclaprim against respiratory and bacteremic isolates of streptococcus pneumoniae. | iclaprim, a novel dihydrofolate reductase inhibitor, inhibited 90% of the clinical isolates (mic(90)) of streptococcus pneumoniae (n = 785) collected by a national surveillance program at a concentration of 1 microg/ml. the mic(90) for iclaprim was 7 doubling dilutions lower for trimethoprim-sulfamethoxazole-susceptible isolates (n = 670; mic(90), 0.06 microg/ml) than for trimethoprim-sulfamethoxazole-resistant isolates (n = 115; mic(90), >or=8 microg/ml). the potential clinical utility of iclap ... | 2009 | 19139284 |
| a class of selective antibacterials derived from a protein kinase inhibitor pharmacophore. | as the need for novel antibiotic classes to combat bacterial drug resistance increases, the paucity of leads resulting from target-based antibacterial screening of pharmaceutical compound libraries is of major concern. one explanation for this lack of success is that antibacterial screening efforts have not leveraged the eukaryotic bias resulting from more extensive chemistry efforts targeting eukaryotic gene families such as g protein-coupled receptors and protein kinases. consistent with a foc ... | 2009 | 19164768 |
| nasopharyngeal carriage and antibiotic resistance of haemophilus influenzae, streptococcus pneumoniae and moraxella catarrhalis in healthy school children in turkey. | 2009 | 19172078 | |
| susceptibilities of haemophilus influenzae, streptococcus pneumoniae, including serotype 19a, and moraxella catarrhalis paediatric isolates from 2005 to 2007 to commonly used antibiotics. | the aim of this study was to evaluate susceptibility to common paediatric antibiotics for streptococcus pneumoniae, non-typeable haemophilus influenzae and moraxella catarrhalis isolated from 2005 through 2007. | 2009 | 19174454 |
| surveillance of pneumococcal-associated disease among hospitalized children in khanh hoa province, vietnam. | to understand the epidemiology of childhood bacterial diseases, including invasive pneumococcal disease, prospective surveillance was conducted among hospitalized children in nha trang, vietnam. | 2009 | 19191620 |
| activity of the new cephalosporin ceftaroline against bacteraemia isolates from patients with community-acquired pneumonia. | the activity of ceftaroline, a novel cephalosporin, was evaluated against 1337 isolates from patients with bacteraemic community-acquired pneumonia (cap) requiring hospitalisation (including 119 haemophilus influenzae, 9 moraxella catarrhalis, 164 staphylococcus aureus, 1007 streptococcus pneumoniae and 38 streptococcus pyogenes). minimum inhibitory concentrations (mics) were determined by broth microdilution according to clinical and laboratory standards institute (clsi) guidelines, and suscept ... | 2009 | 19203863 |
| role of mycoplasma pneumoniae infection in acute exacerbations of chronic obstructive pulmonary disease. | eighty per cent of the cases of acute exacerbation of chronic obstructive pulmonary disease (aecopd) have an infective aetiology, atypical bacteria including mycoplasma pneumoniae accounting for 5-10 % of these. however, the importance of association of m. pneumoniae with episodes of aecopd still remains doubtful. the present study was therefore undertaken to delineate the extent of involvement of m. pneumoniae in patients with aecopd at a referral hospital in delhi, india. sputum samples and th ... | 2009 | 19208881 |
| severe combined immunodeficiency (scid) and attention deficit hyperactivity disorder (adhd) associated with a coronin-1a mutation and a chromosome 16p11.2 deletion. | defects causing severe combined immunodeficiency (scid) have been reported in pathways mediating antigen receptor rearrangement, antigen receptor and cytokine signaling, and purine metabolism. recognizing that the actin regulator coronin-1a is essential for development of a normal peripheral t cell compartment in mouse models, we identified absence of coronin-1a in a girl with t-b+nk+ scid who suffered recurrent infections including severe post-vaccination varicella at age 13 months. murine coro ... | 2009 | 19097825 |