Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| innate immune responses in human hepatocyte-derived cell lines alter genotype 1 hepatitis e virus replication efficiencies. | hepatitis e virus (hev) is a significant health problem in developing countries causing sporadic and epidemic forms of acute viral hepatitis. hepatitis e is a self-limiting disease; however, chronic hev infections are being reported in immunocompromised individuals. the disease severity is more during pregnancy with high mortality (20-25%), especially in third trimester. early cellular responses after hev infection are not completely understood. we analyzed innate immune responses associated wit ... | 2016 | 27230536 |
| hepatitis e virus infection among chronic hemodialysis. | 2016 | 27226872 | |
| hepatitis e virus circulation in italy: phylogenetic and evolutionary analysis. | hepatitis e virus (hev), a major cause of acute viral hepatitis in developing countries, has been classified into four main genotypes and a number of subtypes. new genotypes have been recently identified in various mammals, including hev genotype 3, which has a worldwide distribution. it is widespread among pigs in developed countries. | 2016 | 27226798 |
| in vivo evidence for ribavirin-induced mutagenesis of the hepatitis e virus genome. | hepatitis e virus (hev) infection can take chronic courses in immunocompromised patients potentially leading to liver cirrhosis and liver failure. ribavirin (rbv) is currently the only treatment option for many patients, but treatment failure can occur which has been associated with the appearance of a distinct hev polymerase mutant (g1634r). here, we performed a detailed analysis of hev viral intrahost evolution during chronic hepatitis e infections. | 2016 | 27222534 |
| hepatitis e virus genotype 3 in mussels (mytilus galloprovinciallis), spain. | coastal waters can become contaminated with both human waste from sewage treatment plants and runoff following manure application. thus, shellfish produced close to land can bioaccumulate enteric viruses of human and animal origin, including zoonotic hepatitis e virus that infect both human and swine. the goal of this study was to evaluate the presence of hev in shellfish from galicia (nw spain), a densely populated region with a strong tradition of swine farming, and one of the most important r ... | 2016 | 27217353 |
| thermal stability of hepatitis e virus as estimated by a cell culture method. | hepatitis e virus (hev) is an increasingly recognized zoonotic pathogen. transmission is suspected to occur from infected pigs or wild boars to humans through direct contact, environmental pathways, or contaminated food. however, the physical and chemical stability of hev is largely unknown, because suitable cell culture methods for infectivity measurement are missing. here, we developed a titration method using infection of the cell line a549/d3 with hev genotype 3 strain 47832c and subsequent ... | 2016 | 27208095 |
| hepatitis e: latest developments in knowledge. | hepatitis e, caused by hepatitis e virus (hev), is a highly prevalent disease in developing countries. in developed nations, autochthonous hev infections seem to be an emergent disease. its clinical manifestations and epidemiology are well known for endemic countries. it has been confirmed that hepatitis e is a zoonosis and that parenteral transmission can also occur. the molecular mechanisms of hev replication are not fully understood, mostly because there are no efficient cell culture systems. ... | 2016 | 27203841 |
| hepatitis e virus orf1 encoded macro domain protein interacts with light chain subunit of human ferritin and inhibits its secretion. | hepatitis e virus (hev) is the major causative agent of acute hepatitis in developing countries. its genome has three open reading frames (orfs)-called as orf1, orf2, and orf3. orf1 encodes nonstructural polyprotein having multiple domains, namely: methyltransferase, y domain, protease, macro domain, helicase, and rna-dependent rna polymerase. in the present study, we show that hev-macro domain specifically interacts with light chain subunit of human ferritin (ftl). in cultured hepatoma cells, h ... | 2016 | 27170377 |
| hepatitis e virus in surface water, sediments, and pork products marketed in southern brazil. | hepatitis e virus (hev) is an emerging causative agent of food and waterborne hepatitis in human beings. hev circulates among human populations and swine herds, and may be found in water contaminated by swine feces, as well as in pork. in the present study, 68 sediment samples and 250 water samples collected from the sinos river tributaries, as well as 50 samples of pork products (pâté and blood sausage) marketed in the sinos river watershed region, brazil, were tested for the presence of hev ge ... | 2016 | 27169536 |
| detection of hepatitis e virus in sewage after an outbreak on a french island. | a hepatitis e outbreak, which occurred on a small isolated island, provided an opportunity to evaluate the association between the number of hepatitis e cases in the community and the concentration of virus detected in sewage. samples were collected from the different sewage treatment plants from the island and analyzed for the presence of hepatitis e (hev) virus using real-time rt-pcr. we demonstrated that if 1-4 % of inhabitants connected to a wwtp were infected with hev, raw sewage contained ... | 2016 | 27165600 |
| identification and characterization of avian hepatitis e virus genotype 2 from chickens with hepatitis-splenomegaly syndrome in korea. | a new avian hepatitis e virus (hev) gi-b was identified in broiler breeders with hematomas, liver rupture, and splenomegaly, along with excessive abdominal fat, in korea. previously, genotype 1 had been identified in avian hev strains in korea. complete sequence analyses revealed that the new avian hev clustered in genotype 2, which has been identified in the usa and spain; the gi-b isolate was closely related to the usa prototype avian hev isolated from a chicken with hepatitis-splenomegaly syn ... | 2016 | 27164843 |
| advances in hepatitis e - i: virology, pathogenesis and diagnosis. | infection with hepatitis e virus (hev) is the commonest cause of acute hepatitis worldwide. hev was discovered in 1980s and is known to have small non-enveloped virions with single-stranded rna genome of positive polarity. in recent years. in recent years, availability of new information has changed our understanding of this virus and the pathogenesis of the related disease. | 2016 | 27159083 |
| sero-epidemiological study of hepatitis e virus among thalassemia as high risk patients: a cross-sectional survey in jahrom, southern, iran. | hepatitis e virus (hev) could be cause of viral hepatitis in the developing countries and cause severe epidemics. according to other studies, blood transfusion as a probable route of hev infection has been suggested. an infection with hepatitis agents such as hev causes active liver failure in multi-transfusion patients in particular thalassemia. the purpose of this study determines the seropositivity of anti-hev antibodies in thalassemia individuals in jahrom. in a cross-sectional study, sera f ... | 2016 | 27157168 |
| asialoglycoprotein receptor facilitates infection of plc/prf/5 cells by hev through interaction with orf2. | although the biological and epidemiological features of hepatitis e virus (hev) have been studied extensively in recent years, the mechanism by which hev infects cells is still poorly understood. in this study, coimmunoprecipitation, pull-down, and elisa were used to show that the hev orf2 protein interacts directly with the ectodomain of both asgr1 and asgr2. susceptibility to hev correlated positively with the expression level of surface asialoglycoprotein receptor (asgpr) in cell lines. asgpr ... | 2016 | 27155063 |
| advances in hepatitis e - ii: epidemiology, clinical manifestations, treatment and prevention. | infection with hepatitis e virus (hev) is the commonest cause of acute hepatitis worldwide. this infection, with fecal-oral transmission, was previously thought to be limited to humans residing in developing countries with poor sanitation, spreading via contaminated drinking water. in recent years, our understanding of epidemiology and clinical spectrum of this infection have changed markedly. | 2016 | 27148907 |
| hepatitis e virus in farmed rabbits, wild rabbits and petting farm rabbits in the netherlands. | rabbits have been suggested as a zoonotic source of hepatitis e virus. phylogenetic analysis of hev isolates from farmed, wild and pet rabbits in the netherlands (23, 0, and 60 % respectively) showed them to be grouped amongst published rabbit hev sequences and distinct from most human isolates. dutch rabbits are unlikely to be a zoonotic source. | 2016 | 27147250 |
| identification of distribution characteristics and epidemic trends of hepatitis e in zhejiang province, china from 2007 to 2012. | hepatitis e virus is a common hepatotropic virus that causes serious gastrointestinal symptoms. data of reported hev cases in zhejiang province was collected between 2007 and 2012. descriptive epidemiological methods and spatial-temporal epidemiological methods were used to investigate the epidemiological trends and identify high-risk regions of hepatitis e infection. in this study, the average morbidity of hepatitis e infection was 4.03 per 100,000 in zhejiang province, peaking in winter and sp ... | 2016 | 27146250 |
| screening transfusions for hepatitis e virus: is it needed in india? | 2016 | 27132948 | |
| serum levels of soluble cd26, a novel prognostic marker for hepatitis e infection. | even without treatment, most acute hepatitis e virus (hev) infected patients resolve hev but sometimes the disease leads to acute liver failure, chronic infection, or extrahepatic symptoms. the mechanisms of hev pathogenesis appear to be substantially immune mediated. however, the immune responses to hev are not precisely identified. | 2016 | 27127593 |
| farm-level prevalence and risk factors for detection of hepatitis e virus, porcine enteric calicivirus, and rotavirus in canadian finisher pigs. | hepatitis e virus (hev), norovirus (nov), and rotavirus (rv) are all hypothesized to infect humans zoonotically via exposure through swine and pork. our study objectives were to estimate canadian farm-level prevalence of hev, nov [specifically porcine enteric calicivirus (pec)], and rv in finisher pigs, and to study risk factors for farm level viral detection. farms were recruited using the canadian integrated program for antimicrobial resistance surveillance (cipars) and foodnet canada on-farm ... | 2016 | 27127336 |
| a high-throughput neutralizing assay for antibodies and sera against hepatitis e virus. | hepatitis e virus (hev) is the aetiological agent of enterically transmitted hepatitis. the traditional methods for evaluating neutralizing antibody titres against hev are real-time pcr and the immunofluorescence foci assay (ifa), which are poorly repeatable and operationally complicated, factors that limit their applicability to high-throughput assays. in this study, we developed a novel high-throughput neutralizing assay based on biotin-conjugated p239 (hev recombinant capsid proteins, a.a. 36 ... | 2016 | 27122081 |
| hepatitis a virus and hepatitis e virus seroprevalence among blood donors in tehran, iran. | hepatitis a virus (hav) and hepatitis e virus (hev) are both transmitted by the fecal-oral route and are known as the leading causes of acute viral hepatitis in the world, especially in developing countries. there is a lack of updated data on hav and hev seroprevalence in iran. | 2016 | 27110256 |
| apolipoprotein e ε3 and ε4 are associated with a lower exposure to hepatitis e virus in american non-hispanic blacks. | 2016 | 27098729 | |
| neuralgic amyotrophy associated with hepatitis e virus (hev) infection: a case report. | 2016 | 27095100 | |
| uv disinfection and flocculation-chlorination sachets to reduce hepatitis e virus in drinking water. | hepatitis e virus (hev) is a major cause of waterborne outbreaks in areas with poor sanitation. as safe water supplies are the keystone for preventing hev outbreaks, data on the efficacy of disinfection treatments are urgently needed. here, we evaluated the ability of uv radiation and flocculation-chlorination sachets (fcss) to reduce hev in water matrices. the hev-p6-kernow strain was replicated in the hepg2/c3a cell line, and we quantified genome number using qrt-pcr and infectivity using an i ... | 2016 | 27079972 |
| first reported outbreak of locally acquired hepatitis e virus infection in australia. | to determine the source and extent of a locally acquired hepatitis e virus (hev) infection outbreak. | 2016 | 27078603 |
| local transmission of hepatitis e virus in australia: implications for clinicians and public health. | 2016 | 27078590 | |
| reduced glutathione in hepatitis e infection and pregnancy outcome. | to study reduced glutathione (gsh) as a marker of oxidative stress in hepatitis e virus (hev) infection during pregnancy, and to clarify its association with pregnancy outcome. | 2016 | 27075039 |
| c-terminal amino acids 471-507 of avian hepatitis e virus capsid protein are crucial for binding to avian and human cells. | the infection of chickens with avian hepatitis e virus (avian hev) can be asymptomatic or induces clinical signs characterized by increased mortality and decreased egg production in adult birds. due to the lack of an efficient cell culture system for avian hev, the interaction between virus and host cells is still barely understood. in this study, four truncated avian hev capsid proteins (orf2-1 - orf2-4) with an identical 338aa deletion at the n-terminus and gradual deletions from 0, 42, 99 and ... | 2016 | 27073893 |
| hepatitis e virus (hev)-1 harbouring hev-4 non-structural protein (orf1) replicates in transfected porcine kidney cells. | hepatitis e virus (hev) is a causative agent of acute hepatitis and a major public health problem in india. there are four mammalian hev genotypes worldwide. in india, genotype 1 (hev-1) is restricted to humans whereas genotype 4 (hev-4) circulates in pigs. studies from our laboratory have shown that hev-4 (swine) virus can establish experimental infection in rhesus monkeys; however, hev-1 (human) virus cannot infect pigs. viral and/or cellular factors responsible for this host specificity are n ... | 2016 | 27072797 |
| fulminant hepatic failure from hepatitis e in a non-pregnant female traveller. | a non-pregnant canadian woman returning from india presented with a 1-week history of jaundice and malaise. subsequently, she developed fulminant hepatic failure caused by hepatitis e virus (hev). hev can cause fulminant hepatic failure, most commonly in pregnant women and those with chronic liver disease; however, all travellers are at risk. | 2016 | 27069000 |
| chronic hepatitis e virus infection after living donor liver transplantation via blood transfusion: a case report. | although it occurs worldwide, hepatitis e virus (hev) infection in developed countries is generally foodborne. hev infection is subclinical in most individuals. although fulminant liver failure may occur, progression to chronic hepatitis is rare. this study describes a 41-year-old man with liver cirrhosis caused by non-alcoholic steatohepatitis and hepatocellular carcinoma within the milan criteria. his liver function was classified as child-pugh grade c. living donor liver transplantation (ldlt ... | 2016 | 27059470 |
| persisting hepatitis e virus infection leading to liver cirrhosis despite recovery of the immune system in an hiv-infected patient. | chronic hepatitis e has been described several times in strongly immunosuppressed hiv-patients. we describe the persistence of hev-infection in an hiv-patient despite a restored immune response. this case demonstrates that hev-infection can persist in formerly immunosuppressed individuals irrespective of the current immune status. persisting hev-infection can lead to chronic inflammation and liver cirrhosis. physicians should be aware of the possibility of chronic hepatitis e even in patients th ... | 2016 | 27055386 |
| hepatitis e virus as an emerging zoonotic pathogen. | hepatitis e outbreaks are a serious public health concern in developing countries. the disease causes acute infections, primarily in young adults. the mortality rate is approximately 2%; however, it can exceed 20% in pregnant women in some regions in india. the causative agent, hepatitis e virus (hev), has been isolated from several animal species, including pigs. hev genotypes 3 and 4 have been isolated from both humans and animals, and are recognized as zoonotic pathogens. seroprevalence studi ... | 2016 | 27051334 |
| hepatitis e in children: a position paper by the espghan hepatology committee. | hepatitis e virus (hev) is endemic in large parts of the developing world. waterborne transmission of genotypes 1 or 2 commonly causes acute hepatitis, which is usually self-limited in healthy individuals. in addition, acute hev infections also occur outside endemic areas, mostly related to foodborne transmission of hev genotype 3. a growing number of publications in the last decade have reported chronic infection progressing to cirrhosis in immunosuppressed patients. it has also been suggested ... | 2016 | 27050048 |
| the hepatitis e virus: a likely cause of extrahepatic diseases! | 2016 | 27005693 | |
| extrahepatic manifestations of hepatitis e virus. | hepatitis e virus can cause acute, fulminant and chronic hepatitis and has been associated with a range of extrahepatic manifestations. guillain-barré syndrome, neuralgic amyotrophy and encephalitis are the main neurological manifestations associated with acute and chronic hepatitis e virus infection. renal injuries have been also reported, including membranoproliferative glomerulonephritis with or without cryoglobulinemia and membranous glomerulonephritis. acute pancreatitis, haematological dis ... | 2016 | 27005692 |
| characterization and epitope mapping of monoclonal antibodies raised against rat hepatitis e virus capsid protein: an evaluation of their neutralizing activity in a cell culture system. | hepatitis e virus (hev) is the causative agent of acute hepatitis. rat hev is a recently discovered virus related to, but distinct from, human hev. since laboratory rats can be reproducibly infected with rat hev and a cell culture system has been established for rat hev, this virus may be used as a surrogate virus for human hev, enabling studies on virus replication and mechanism of infection. however, monoclonal antibodies (mabs) against rat hev capsid (orf2) protein are not available. in this ... | 2016 | 26992654 |
| microbiological characterization of a newly established pig breed, aachen minipigs. | to alleviate the shortage of human donor organs or tissues for the treatment of organ and tissue failure including diabetes, pigs are considered suitable donor animals. as organs from conventional pigs are usually too large, those from minipigs may be better suited. we recently characterized the göttingen minipigs, a breed well characterized concerning the presence of zoonotic microorganisms and found hepatitis e virus (hev) and porcine cytomegalovirus (pcmv) in some animals. here, we characteri ... | 2016 | 26991265 |
| new insights into the natural history of hepatitis e virus infection through a longitudinal study of multitransfused immunocompetent patients in france. | little is known about the natural history of hepatitis e virus (hev) infection in immunocompetent individuals. the prevalence, the course of infection and the occurrence of transmission by transfusion were investigated in multitransfused immunocompetent patients/blood donor pairs included in a longitudinal sample repository collection and followed up between 1988 and 2010. ninety-eight subjects aged 6-89 years and suffering from acquired haemoglobinopathies were tested for hev markers (igm, igg ... | 2016 | 26990022 |
| hepatitis e virus prevalence among blood donors, ouagadougou, burkina faso. | 2016 | 26982195 | |
| update on hepatitis e virology: implications for clinical practice. | hepatitis e virus (hev) is a positive-strand rna virus transmitted by the fecal-oral route. the 7.2kb genome encodes three open reading frames (orf) which are translated into (i) the orf1 polyprotein, representing the viral replicase, (ii) the orf2 protein, corresponding to the viral capsid, and (iii) the orf3 protein, a small protein involved in particle secretion. although hev is a non-enveloped virus in bile and feces, it circulates in the bloodstream wrapped in cellular membranes. hev genoty ... | 2016 | 26966047 |
| [hepatitis e virus (hev) infection analysis of patients with maintenance haemodialysis]. | 2016 | 26957250 | |
| characterization of seven outbreaks of hemorrhagic hepatopathy syndrome in commercial pullets following the administration of a salmonella enteritidis bacterin in california. | between april 2013 and april 2015, seven flocks belonging to three different major commercial egg producers incalifornia experienced a mild increase in mortality 2 to 3 wk after administration of salmonella enteritidis bacterins. strains of chickens involved were h&n (flock a1, a2, b2, c1, c2, and c3) and lohmann white (flock b1). vaccination was administered individually through injection either in the breast muscles or subcutis in the legs between 11 and 18 wk of age in all flocks. clinical si ... | 2016 | 26953941 |
| conventional and innate lymphocytes response at the acute phase of hev infection in transplanted patients. | the hepatitis e virus (hev) causes usually benign and spontaneously resolving acute hepatitis in immunocompetent individuals. in immunocompromised patients with a solid-organ transplant (sot), chronic infections occur in about 2/3 of cases. we aimed to evaluate the immune cells implicated at the acute phase of hev infection. | 2016 | 26947133 |
| hepatitis e virus infection as a direct cause of neuralgic amyotrophy. | we describe a patient who developed neuralgic amyotrophy (na) related to hepatitis e virus (hev) infection. | 2016 | 26939568 |
| new immunoassays for total, iga and igm antibodies against hepatitis e virus: prevalence in italian blood donors and patients with chronic liver or kidney diseases. | hepatitis e virus (hev) is a zoonotic agent that causes acute hepatitis in humans with sporadic infections and outbreaks in developing countries worldwide. the global spread of hev remains underestimated because of subclinical infections and lack of sensitive diagnostic assays. | 2016 | 26936342 |
| evaluation of rapid tests for diagnosis of acute hepatitis e. | hepatitis e virus diagnosis still presents difficulties due to discordant results among diagnostic tests. | 2016 | 26930580 |
| transmission of hepatitis e virus by plasma exchange: a case report. | 2016 | 26926359 | |
| serologic evidence for hepatitis e virus infection among patients with undifferentiated acute febrile illness in kibera, kenya. | hepatitis e (hev) is an emerging cause of viral hepatitis mainly transmitted through the fecal-oral route. residents of the kibera slum of nairobi, kenya are at risk for fecal-orally transmitted infections. | 2016 | 26925954 |
| first update of the international xenotransplantation association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes--chapter 5: recipient monitoring and response plan for preventing disease transmission. | xenotransplantation of porcine cells, tissues, and organs may be associated with the transmission of porcine microorganisms to the human recipient. a previous, 2009, version of this consensus statement focused on strategies to prevent transmission of porcine endogenous retroviruses (pervs). this version addresses potential transmission of all porcine microorganisms including monitoring of the recipient and provides suggested approaches to the monitoring and prevention of disease transmission. pr ... | 2016 | 26918415 |
| hepatitis e virus is the leading cause of acute viral hepatitis in lothian, scotland. | acute viral hepatitis affects all ages worldwide. hepatitis e virus (hev) is increasingly recognized as a major cause of acute hepatitis in europe. because knowledge of its characteristics is limited, we conducted a retrospective study to outline demographic and clinical features of acute hev in comparison to hepatitis a, b and c in lothian over 28 months (january 2012 to april 2014). a total of 3204 blood samples from patients with suspected acute hepatitis were screened for hepatitis a, b and ... | 2016 | 26904201 |
| a preliminary cost-effectiveness analysis of hepatitis e vaccination among pregnant women in epidemic regions. | objective to estimate the cost-effectiveness of hepatitis e vaccination among pregnant women in epidemic regions. methods a decision tree model was constructed to evaluate the cost-effectiveness of 3 hepatitis e virus vaccination strategies from societal perspectives. the model parameters were estimated on the basis of published studies and experts' experience. sensitivity analysis was used to evaluate the uncertainties of the model. results vaccination was more economically effective on the bas ... | 2016 | 26900799 |
| hepatitis e virus: an ancient hidden enemy in latin america. | hepatitis e virus (hev) infection is a common cause of acute clinical hepatitis worldwide. hev is an rna-containing virus and the only member of the genus hepevirus in the family hepeviridae. human hev is classified into four genotypes widely distributed across the world. the virus is mainly transmitted via the fecal-oral route, and water-borne epidemics have become characteristic of hepatitis e in developing countries, including those in latin america. the zoonotic potential of hev is broadly r ... | 2016 | 26900289 |
| a mouse model for hepatitis e virus infection. | 2016 | 26892936 | |
| extra-hepatic replication and infection of hepatitis e virus in neuronal-derived cells. | hepatitis e virus (hev) is the causative agent of hepatitis e in humans and a member of the genus orthohepevirus in the family hepeviridae. infection usually leads to acute hepatitis that can become fulminant, particularly among pregnant women and in patients with preexisting liver disease, or may evolve to a chronic state, especially in immunosuppressed individuals. hev has been shown to produce a range of extra-hepatic manifestations including aplastic anaemia, acute thyroiditis, glomeruloneph ... | 2016 | 26891712 |
| risk factors and sources of foodborne hepatitis e virus infection in the united states. | hepatitis e virus (hev) is an important human pathogen with pigs and other species serving as natural animal reservoirs. ample evidence documents sporadic cases of hepatitis e acquired via consumption of undercooked meat. chronic hepatitis e cases in immunosuppressed individuals are mostly caused by zoonotic hev of swine origin. we report here the identification of genotype 3 hev from non-liver commercial pork from local grocery stores in southwest virginia, and association of hev seropositivity ... | 2016 | 26889628 |
| hepatitis e virus (hev) genotype 3 infection of human liver chimeric mice as a model for chronic hev infection. | genotype 3 (gt3) hepatitis e virus (hev) infections are emerging in western countries. immunosuppressed patients are at risk of chronic hev infection and progressive liver damage, but no adequate model system currently mimics this disease course. here we explore the possibilities of in vivo hev studies in a human liver chimeric mouse model (upa(+/+)nod-scid-il2rγ(-/-)) next to the a549 cell culture system, using hev rna-positive edta-plasma, feces, or liver biopsy specimens from 8 immunocompromi ... | 2016 | 26889028 |
| hepatitis e virus genotype 3 in colombia: survey in patients with clinical diagnosis of viral hepatitis. | hepatitis e virus is a major cause of outbreaks as well as sporadic hepatitis cases worldwide. the epidemiology of this enterically transmitted infection differs between developing and developed countries. the aims of this study were to describe hev infection in colombian patients and to characterize the genotype. | 2016 | 26886728 |
| characterization of hepatitis e virus infection in tree shrew (tupaia belangeri chinensis). | hepatitis e virus (hev) is a major cause of hepatitis in developing countries and poses a threat to public health worldwide. tree shrew (tupaia belangeri chinensis) is a useful animal model in studies on hepatitis viruses, such as hepatitis b and c viruses. however, the use of this animal model for hev research is yet to be developed. | 2016 | 26880187 |
| prevalence of hepatitis e virus (hev) antibodies in mexican pigs. | the hepatitis e virus (hev) is the causative agent of hepatitis e, an enterically transmitted disease. hev infections in pigs and humans have been reported worldwide, but data from mexico are scarce. in the present study, the prevalence of anti-hev igg antibodies was investigated in a quite large number of swine from mexico by means of an elisa based on a recombinant open reading frame 2 protein of hev genotype 3. serum samples from 683 healthy pigs (1-48 months old), collected during 2010-2013 ... | 2016 | 26880004 |
| serological survey of hepatitis e virus infection in farmed and pet rabbits in italy. | the recent identification in rabbits of hepatitis e viruses (hev) related to viruses infecting humans raises the question of the role of this species as possible hev reservoir. a serological survey on rabbit hev infection was conducted in italy during 2013-2014, including both farmed and pet rabbits. we found an anti-hev antibody seroprevalence of 3.40 % in 206 farmed rabbits (collected on 7 farms) and 6.56 % in 122 pets. rna was extracted from igg-positive sera and analyzed by hev-specific real ... | 2016 | 26873813 |
| hepatitis e virus genotype 4 in southeastern france: still around. | 2016 | 26216587 | |
| erratum to: evidence of mapk-jnk1/2 activation by hepatitis e virus orf3 protein in cultured hepatoma cells. | 2016 | 25535116 | |
| hepatitis e virus in sylvatic and captive wild boar from portugal. | hepatitis e virus (hev) is a zoonotic agent today considered a major public health issue in industrialized countries. hev strains belonging to zoonotic genotype 3 are widely present in swine, being today considered important reservoirs for human disease. unlike in swine, only scarce data are available on the circulation of hev in wild boar. this study describes the detection and molecular characterization of hev in livers from sylvatic wild boar hunted in portugal and destined for consumption. a ... | 2016 | 25405272 |
| meeting report: 2013 pda virus & tse safety forum. | the report provides a summary of the presentations and discussions at the virus & tse safety forum 2013 organized by the parenteral drug association (pda) and held in berlin, germany, from june 4 to 6, 2013. the conference was accompanied by a workshop, "virus spike preparations and virus removal by filtration: new trends and developments". the presentations and the discussion at the workshop are summarized in a separate report that will be published in this issue of the journal as well. as with ... | 2016 | 25188343 |
| hepatitis e virus infection. | hepatitis resulting from viral infection is common worldwide and is associated with significant morbidity and mortality. caused by a group of unrelated viruses that target the liver, hepatitis e virus is not well understood and is consequently often perceived in many countries as unimportant. this article describes the main features of hepatitis e virus and reviews global patterns of transmission, endemicity and the variable clinical outcomes of infection, especially in pregnant women and anyone ... | 2016 | 23855159 |
| suggestions for the diagnosis and elimination of hepatitis e virus in pigs used for xenotransplantation. | the hepatitis e virus (hev) is considered a zoonotic pathogen. in xenotransplantation, given the high prevalence of hev infection in pigs, the risk of zoonotic transmission from a porcine source is considered high. currently no clear data are available on how to diagnose and eliminate hev in herds used for medical purposes and the importance of viral infection at the stage of harvest. in this study, several groups of animals currently used for medical purposes were found rna positive in both ser ... | 2016 | 23647385 |
| evaluation of antigenicity and cell mediated immunity of hepatitis e virus patients: using non radioactive mtt assay. | hepatitis e virus (hev) is an important cause of hepatitis in developing nations. disease spans from asymptomatic infection to acute viral hepatitis (avh) and acute liver failure (alf). cell-mediated immunity (cmi) is less studied. studies document cmi in hev patients using [3 h]-thymidine incorporation (radioactive in nature). the aim of this study was to evaluate the antigenicity of recombinant hev orf 2 peptide (452-617 a.a) (porf2) by non-radioactive mtt assay and detecting the proliferation ... | 2016 | 23508432 |
| ribavirin treatment of a patient with chronic hepatitis e. first case reported in latin america. | we describe a clinical case of a kidney transplant patient who presented a sudden elevation of his liver function tests. once we ruled out the most frequent causes of acute hepatitis, serum tests for hepatitis e were performed. hepatitis e virus rna was detected in blood and stools. after six months the virus was still detected. ribavirin treatment was initiated with normalization of the serum aminotransferases and sustained virology response was achieved. | 2016 | 28704018 |
| first report of hepatitis e virus viremia in healthy blood donors from nepal. | the aim of this study was to detect the prevalence of hepatitis e virus (hev) in healthy blood donors so as to decipher the maintenance of (hev) reservoir if any. five hundred and eighty-one blood samples along with clinical information were collected from central blood bank, kathmandu between february and march 2014. samples were tested for hepatitis b virus surface antigen, anti-hepatitis c virus antibodies, anti-hepatitis a virus igm, hev antigen, hev viral load and anti-hev antibodies (igm a ... | 2016 | 28466048 |
| systematic review of mixed cryoglobulinemia associated with hepatitis e virus infection: association or causation? | background and aim: mixed cryoglobulinemia (mc) has been associated with several viral infections, and chronic hepatitis c is recognized as a major cause. mc associated with hepatitis e virus (hev) has been described and little is known about this rare association. the aim of this study is to perform a systematic review of mc associated with hev, and examine the presence of a causal relationship. methods: an experienced librarian conducted a search of databases from each database's inception to ... | 2017 | 28852522 |
| nucleoside analogue 2'-c-methylcytidine inhibits hepatitis e virus replication but antagonizes ribavirin. | hepatitis e virus (hev) infection has emerged as a global health issue, but no approved medication is available. the nucleoside analogue 2'-c-methylcytidine (2cmc), a viral polymerase inhibitor, has been shown to inhibit infection with a variety of viruses, including hepatitis c virus (hcv). here, we report that 2cmc significantly inhibits the replication of hev in a subgenomic replication model and in a system using a full-length infectious virus. importantly, long-term treatment with 2cmc did ... | 2017 | 28623406 |
| hepatitis e virus persists in the presence of a type iii interferon response. | the rig-i-like rna helicase (rlr)-mediated interferon (ifn) response plays a pivotal role in the hepatic antiviral immunity. the hepatitis a virus (hav) and the hepatitis c virus (hcv) counter this response by encoding a viral protease that cleaves the mitochondria antiviral signaling protein (mavs), a common signaling adaptor for rlrs. however, a third hepatotropic rna virus, the hepatitis e virus (hev), does not appear to encode a functional protease yet persists in infected cells. we investig ... | 2017 | 28558073 |
| unphosphorylated isgf3 drives constitutive expression of interferon-stimulated genes to protect against viral infections. | interferon (ifn)-stimulated genes (isgs) are antiviral effectors that are induced by ifns through the formation of a tripartite transcription factor isgf3, which is composed of irf9 and phosphorylated forms of stat1 and stat2. however, we found that ifn-independent isg expression was detectable in immortalized cell lines, primary intestinal and liver organoids, and liver tissues. the constitutive expression of isgs was mediated by the unphosphorylated isgf3 (u-isgf3) complex, consisting of irf9 ... | 2017 | 28442624 |
| high prevalence of hepatitis e virus in semen of infertile male and causes testis damage. | 2017 | 28860349 | |
| complete genome sequences of two swiss hepatitis e virus isolates from human stool and raw pork sausage. | we present here the full-length genome sequences of two hepatitis e virus genotype 3 (hev-3) isolates from a human stool sample from a patient with acute hepatitis and a raw sausage containing pig liver. sequence analysis implies that swiss hev isolates may form a novel subgroup of hev-3 viruses. | 2017 | 28860248 |
| hepatitis e virus-induced primary cutaneous cd30(+) t cell lymphoproliferative disorder. | several types of unexplained extra-hepatic manifestations, including haematological disorders, have been reported in the context of hepatitis e virus (hev) infection. however, the underlying mechanism(s) of these manifestations are unknown. we provide evidence that hev has an extra-hepatic endothelial tropism that can engage cutaneous t cells towards clonality. | 2017 | 28860025 |
| hepatitis e virus infection as a promoting factor for hepatocellular carcinoma in cameroon: preliminary observations. | to determine the seroprevalence of hepatitis e virus (hev) infection in patients with chronic hepatitis and/or hepatocellular carcinoma (hcc) and to assess its potential consequences for disease progression. | 2017 | 28847760 |
| hepatitis e virus as a cause of acute hepatitis acquired in switzerland. | autochthonous hepatitis e is increasingly recognized as zoonotic infection in western countries. serologic assays have varying sensitivity and specificity. | 2017 | 28834649 |
| hepatitis e virus rna in australian blood donors: prevalence and risk assessment. | hepatitis e virus (hev) is a known transfusion-transmissible agent. hev infection has increased in prevalence in many developed nations with rna detection in donors as high as 1 in 600. a high proportion of hev infections are asymptomatic and therefore not interdicted by donor exclusion criteria. to manage the hev transfusion-transmission (tt) risk some developed nations have implemented hev rna screening. in australia, hev is rarely notified; although locally acquired infections have been repor ... | 2017 | 28833229 |
| low hepatitis e virus rna prevalence in a large-scale survey of united states source plasma donors. | hepatitis e virus (hev) is a small, nonenveloped, single-stranded, rna virus of emerging concern in industrialized countries. hev transmission through transfusion of blood components has been reported, but not via plasma-derived medicinal products (pdmps) manufactured with virus inactivation and/or removal steps. this study aimed to determine the prevalence of hev among us source plasma donors. | 2017 | 28833188 |
| full-length genome of a novel genotype 3 hepatitis e virus strain obtained from domestic pigs in japan. | hepatitis e virus (hev) causes acute or chronic hepatitis in humans and can be transmitted via the fecal-oral route. pigs are one of the main reservoirs for this infection. sixty pigs, 4-5 months of age, on a swine herd in japan had detectable anti-hev igg antibodies, and five (8.3%) of them had ongoing infection of genotype 3 hev. five hev strains obtained from the viremic pigs shared 98.8-100% nucleotide identity, and one representative strain (swhe1606845), whose entire genomic sequence was d ... | 2017 | 28822700 |
| risk factors associated with blood exposure for sporadic hepatitis e in dhaka, bangladesh. | fecal contamination of drinking water is associated with large hepatitis e virus (hev) outbreaks of genotypes 1 and 2 in endemic areas. sporadic transmission of hev genotypes 3 and 4 in high-income countries has been associated with exposure to blood and animal contact. the objective of the study was to identify the risk factors for hepatitis e and the genotype(s) causing sporadic hepatitis e in dhaka, bangladesh. we selected, from a diagnostic center in dhaka between november 2008 and november ... | 2017 | 28820721 |
| estimated annual numbers of foodborne pathogen-associated illnesses, hospitalizations, and deaths, france, 2008-2013. | estimates of the annual numbers of foodborne illnesses and associated hospitalizations and deaths are needed to set priorities for surveillance, prevention, and control strategies. the objective of this study was to determine such estimates for 2008-2013 in france. we considered 15 major foodborne pathogens (10 bacteria, 3 viruses, and 2 parasites) and estimated that each year, the pathogens accounted for 1.28-2.23 million illnesses, 16,500-20,800 hospitalizations, and 250 deaths. campylobacter ... | 2017 | 28820137 |
| valuable antibody detection method for classifying hepatitis e virus genotypes. | nucleotide-based methods are conventionally used to classify the hepatitis e virus (hev) genotypes. a serological enzyme immunoassay (eia) using open reading frame 3 (orf3) c-terminal peptides was developed to conveniently and accurately classify and evaluate the genotypes of hev. the sera of mice immunized with hev genotype 1, 3 and 4 reacted highly specifically to the peptides of the corresponding genotypes. most (84.2%) clinical sera infected with hev genotype 4 were positive for anti-hev ant ... | 2017 | 28817198 |
| zinc salts block hepatitis e virus replication by inhibiting the activity of viral rna-dependent rna polymerase. | hepatitis e virus (hev) causes an acute, self limiting hepatitis in normal individuals and leads to chronic disease in immunocompromised individuals. hev infection in pregnant women results in a more severe outcome, with the mortality rate going upto 30%. though the virus usually causes sporadic infection, epidemics have been reported in developing and resource starved countries. no specific anti-viral exists against hev. a combination of interferon and ribavirin therapy has been used to control ... | 2017 | 28814517 |
| a phase 1 randomized open-label clinical study to evaluate the safety and tolerability of a novel recombinant hepatitis e vaccine. | this study aimed to evaluate the safety and tolerability for variable dosages of a novel hepatitis e vaccine p179. | 2017 | 28803715 |
| summary of the british transplantation society uk guidelines for hepatitis e and solid organ transplantation. | the incidence and prevalence of hepatitis e virus (hev) infection has increased in many developed countries over the last decade, predominantly due to infection with genotype 3 (g3) hev. infection with hev g3 is important in transplant recipients because it can persist in immunosuppressed individuals, leading if untreated to the development of chronic hepatitis and significant liver fibrosis. the british transplantation society (bts) has developed guidelines for "hepatitis e & solid organ transp ... | 2017 | 28795981 |
| unexplained abnormal liver function in patients with primary antibody deficiency: could it be chronic hepatitis e infection? | data from recent studies suggest rising incidence rate of hepatitis e virus (hev) infection in the uk. hev infection may take a severe and persistent course in immunocompromised patients, including transplant recipients on immunosuppressives, patients with hiv, haematological malignancies and in idiopathic cd4(+) t lymphocytopenia. the prevalence of hev in primary antibody deficiency (pad) disorders is still unknown. the aim of this study was to investigate hev infection in 27 patients with pad ... | 2017 | 28794125 |
| frequency of hepatitis e virus, rotavirus and porcine enteric calicivirus at various stages of pork carcass processing in two pork processing plants. | hepatitis e virus (hev), rotavirus (rv), and porcine enteric calicivirus (pec) infections are common in swine and raises concerns about the potential for zoonotic transmission through undercooked meat products. enteric viruses can potentially contaminate carcasses during meat processing operations. there is a lack of information on the prevalence and control of enteric viruses in the pork processing chain. this study compared the incidence and levels of contamination of hog carcasses with hev, r ... | 2017 | 28783534 |
| distinct changing profiles of hepatitis a and e virus infection among patients with acute hepatitis in mongolia: the first report of the full genome sequence of a novel genotype 1 hepatitis e virus strain. | in january 2012, mongolia started a hepatitis a vaccination program, which has not yet been evaluated. the first occurrence of autochthonous acute hepatitis e in 2013, caused by genotype 4 hepatitis e virus (hev), suggests the need for a routine study to monitor its prevalence. one hundred fifty-four consecutive patients who were clinically diagnosed with acute hepatitis between 2014 and 2015 in ulaanbaatar, mongolia were studied. by serological and molecular testing followed by sequencing and p ... | 2017 | 28776712 |
| a cross-sectional study among polish hunters: seroprevalence of hepatitis e and the analysis of factors contributing to hev infections. | hepatitis e virus (hev) is known as zoonotic agent. the main reservoirs of hev in europe are pigs, wild boars, and deer. hunting activity is considered to be a risk factor for hev infection. we conducted a cross-sectional study among 1021 polish hunters. to understand socio-demographic characteristics of this population and to gather information on potential exposures, all participants completed a questionnaire. commercial immunoassays were employed to estimate seroprevalence anti-hev. samples w ... | 2017 | 28776194 |
| clinical phenotype and outcome of hepatitis e virus-associated neuralgic amyotrophy. | to determine the clinical phenotype and outcome in hepatitis e virus-associated neuralgic amyotrophy (hev-na). | 2017 | 28768846 |
| different susceptibility and pathogenesis of rabbit genotype 3 hepatitis e virus (hev-3) and human hev-3 (jrc-he3) in spf rabbits. | hepatitis e virus (hev) is an increasingly important zoonotic infection in humans with hev genotypes 3 and 4 being recognized as zoonotic pathogens. the relatively recently isolated genotype 3 rabbit hev (rhev-3) and the more well known genotype 3 isolates from humans and swine (hshev-3) have all been confirmed experimentally to be capable of infecting both non-human primates and specific-pathogen free (spf) pigs. in a previous study rhev-3 was shown to cause acute hepatitis in experimentally in ... | 2017 | 28757007 |
| pork products associated with human infection caused by an emerging phylotype of hepatitis e virus in england and wales. | since 2010, human hepatitis e infections have increased in england and wales. most cases are locally acquired and caused by hepatitis e virus genotype 3 (hev g3). hev g3 is linked to the consumption of pork products. the increase is associated with the emergence of a new phylotype, hev g3-group 2 (g3-2, also known as g3abcdhij). sixty individuals with confirmed hepatitis e infection and no history of travel outside the uk were recruited: 19 were infected with hev g3-group 1 (g3-1 or g3efg) and 4 ... | 2017 | 28756783 |
| the serological surveillance of hepatitis e virus among hunters and foresters in eastern poland. | the aim of the study was the analysis of the occurrence of specific antibodies against hev among hunters and foresters who are at risk to be exposed. the study group consisted of 210 hunters (23-80 years old) and 60 foresters (22-64 years old). anti-hev igg were present in 3.81% of the samples of the hunters and in 5% of the samples of the foresters. the statistical analysis shows no significant differences in the results anti-hev igg between the groups of hunters and foresters (p = 0.5278). sig ... | 2017 | 28735306 |
| hepatitis e virus infection and acute non-traumatic neurological injury: a prospective multicentre study. | hepatitis e virus (hev) has been associated with a number of neurological syndromes, but causality has not yet been established. the aim of this study was to explore the relationship between hev and neurological illness by prospective hev testing of patients presenting with acute non-traumatic neurological injury. | 2017 | 28734938 |
| genotype-specific acquisition, evolution and adaptation of characteristic mutations in hepatitis e virus. | hepatitis e virus (hev) infection is a major cause of acute hepatitis but also provokes chronic infection in immunocompromised patients. although the pathogenesis and treatment outcome involve complex interplay between the virus and host, the nature of adaptive responses of hev to the host immune system remain obscure at best. in this study, we used large-scale proteomic bioinformatics to profile characteristic mutations in human hev isolates associated to ribavirin treatment failure, chronic he ... | 2017 | 28727933 |
| isg15 modulates type-i interferon signaling and antiviral response during hepatitis e virus replication. | hepatitis e virus (hev), a single-stranded positive-sense rna virus, generally causes a self-limiting acute viral hepatitis, although chronic hev infection has recently become a significant clinical problem in immunocompromised individuals especially in solid organ transplant recipients. innate immunity, via type-i interferon (ifn) response, plays an important role during initial stages of a viral infection. isg15, an ifn-induced ubiquitin-like protein, is known to have an immunomodulatory role, ... | 2017 | 28724761 |