Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| human papillomavirus type 16 e6 and e7 oncoproteins upregulate c-iap2 gene expression and confer resistance to apoptosis. | inhibition of apoptosis plays an important role in the cellular immortalization and transformation induced by e6 and e7 oncoproteins of human papillomavirus (hpv). here, we report that the transcription of the inhibitor of apoptosis gene, cellular inhibitor of apoptosis protein 2, (c-iap2), is significantly upregulated in hpv16 e6/e7-immortalized human oral keratinocytes (hok16e6e7). overexpression of e6/e7 from the high-risk hpv16 or 18, but not from the low-risk hpv6, activated c-iap2 promoter ... | 2005 | 15856013 |
| marginal periodontium as a potential reservoir of human papillomavirus in oral mucosa. | although human papillomaviruses (hpvs) are associated with a number of proliferative epithelial lesions including squamous cell malignancies, they can also be detected in the normal oral mucosa in 10% to 20% of the adult population. however, the point of entry and the site of replication of hpv in the oral cavity are not known. since the gingival pocket is the only site in the oral mucosa where basal cells, known to be targets of hpv at other mucosal sites, are normally exposed to the environmen ... | 2005 | 15857068 |
| variant upstream regulatory region sequences differentially regulate human papillomavirus type 16 dna replication throughout the viral life cycle. | while the central role of the viral upstream regulatory region (urr) in the human papillomavirus (hpv) life cycle has been well established, its effects on viral replication factor expression and plasmid replication of hpv type 16 (hpv16) remain unclear. some nonprototypic variants of hpv16 contain altered urr sequences and are considered to increase the oncogenic risk of infections. to determine the relationship between viral replication and variant urrs, hybrid viral genomes were constructed w ... | 2005 | 15857977 |
| p16ink4a, cdc6, and mcm5: predictive biomarkers in cervical preinvasive neoplasia and cervical cancer. | to analyse and compare expression patterns of three potential biomarkers-p16(ink4a), cdc6, and mcm5-and evaluate their use as predictive biomarkers in squamous and glandular cervical preinvasive neoplasia. | 2005 | 15858126 |
| establishment and characterization of a human first-trimester extravillous trophoblast cell line (tev-1). | research into the biology of human trophoblast invasion has been hampered by a lack of in vitro models. the aim of this study was to establish and characterize a human extravillous trophoblast cell line from the first-trimester placenta. | 2005 | 15866109 |
| detection of human papillomavirus type 16 in bowen's disease of the web-space of the foot. | 2005 | 15868648 | |
| human papillomavirus infection and p16(ink4a) protein expression in vulvar intraepithelial neoplasia and invasive squamous cell carcinoma. | vulvar intraepithelial neoplasia (vin) is defined histopathologically by distinctive abnormalities of cellular maturation and differentiation. the purpose of this study was to investigate the functional properties of vin related to expression of p16(ink4a) protein as well as to detection of human papillomavirus (hpv) type 16 by real-time polymerase chain reaction (rt-pcr) analysis. | 2005 | 15870532 |
| viral oncoprotein-induced mislocalization of select pdz proteins disrupts tight junctions and causes polarity defects in epithelial cells. | the development of human cancers is frequently associated with a failure of epithelial cells to form tight junctions and to establish proper apicobasal polarity. interestingly, the oncogenic potential of the adenovirus e4-orf1 protein correlates with its binding to the cellular pdz proteins mupp1, magi-1, zo-2 and sap97, the first three of which assemble protein complexes at tight junctions. given that e4-orf1 sequesters these three pdz proteins in the cytoplasm of fibroblasts, we postulated tha ... | 2005 | 16141229 |
| human papillomavirus vaccines and adolescents. | this review will describe human papillomavirus (hpv) vaccines in development, summarize data regarding safety and efficacy of these vaccines, and discuss key issues related to hpv vaccine implementation. | 2005 | 16141761 |
| [usefulness of searching for human papillomavirus (hpv): evaluation of screening practices for precancerous lesions of the uterine cervix]. | 2005 | 16142172 | |
| dna vaccines based on chimeric potyvirus-like particles carrying hpv16 e7 peptide (aa 44-60). | vaccine strategies for the treatment of human papillomavirus-induced cervical cancer are based mainly on the human papillomavirus 16 e7 (hpv16 e7) oncoprotein. the immunogenicity of the e7 gene has been enhanced by its fusion to many different genes. here, we linked a short sequence coding for the e7 peptide (aa 44-60) containing immunodominant epitopes for b and t cells to the 3' end of the gene coding for the whole coat protein (cp) of the poty-virus, potato virus a (pva), and its deleted form ... | 2005 | 16142370 |
| the expression of p53 protein and infection of human papilloma virus in conjunctival and eyelid neoplasms. | human papilloma virus (hpv) infection and loss of p53 function have been identified as frequent events in various human tumors. the aim of this study was to evaluate p53 protein expression and to detect hpv in the tissue samples of 45 benign (papillomas) and 38 malignant conjunctival and eyelid lesions (27 basal cell carcinomas and 11 squamous cell carcinomas). we also looked for eventual relationships between p53 expression and clinicopathological features such as age, histological type of tumo ... | 2005 | 16142387 |
| requirement of epidermal growth factor receptor for hyperplasia induced by e5, a high-risk human papillomavirus oncogene. | multicellular organisms rely on complex networks of signaling cascades for development, homeostasis, and responses to the environment. these networks involve diffusible signaling molecules, their receptors, and a variety of downstream effectors. alterations in the expression or function of any one of these factors can contribute to disease, including cancer. many viruses have been implicated in cancer, and some of these modulate cellular signal transduction cascades to carry out their life cycle ... | 2005 | 16061632 |
| association of the human papillomavirus type 16 e7 oncoprotein with the 600-kda retinoblastoma protein-associated factor, p600. | the human papillomavirus type 16 (hpv-16) e7 gene encodes a multifunctional oncoprotein that can subvert multiple cellular regulatory pathways. the best-known cellular targets of the hpv-16 e7 oncoprotein are the retinoblastoma tumor suppressor protein prb and the related pocket proteins p107 and p130. however, there is ample evidence that e7 has additional cellular targets that contribute to its transforming potential. we isolated hpv-16 e7 associated cellular protein complexes by tandem affini ... | 2005 | 16061792 |
| anal cytology: is there a role for reflex hpv dna testing? | there is an increased incidence of anal squamous carcinoma and its precursor lesions (anal intraepithelial neoplasia [ain]) among persons who engage in anal-receptive sex. analogous to cervical cancer screening, anal papanicplaou (pap) smears currently are used to screen these high-risk populations. human papilloma virus (hpv) has been implicated in anal carcinoma pathogenesis and this study was performed to assess the potential role of hpv dna testing as an adjunct to anal cytology. we correlat ... | 2005 | 16078257 |
| concordance of specific human papillomavirus types in sex partners is more prevalent than would be expected by chance and is associated with increased viral loads. | genital human papillomavirus (hpv) infections are generally accepted to be sexually transmitted, but studies of hpv infections in sex partners are limited. we investigated hpv type-specific concordance and viral load in 238 heterosexual couples. women with cervical intraepithelial neoplasia were the index patients in these couples. | 2005 | 16080082 |
| concordance of human papillomavirus (hpv) type between sex partners: implications for effective utilization of an hpv vaccine. | 2005 | 16080083 | |
| incomplete inhibition of the rb tumor suppressor pathway in the context of inactivated p53 is sufficient for pancreatic islet tumorigenesis. | here, we describe the surprising residual capability of the rb pathway to negatively regulate proliferation and tumorigenesis in a sv40 large t antigen (tag)-driven mouse model of pancreatic islet carcinogenesis. heterogeneous tag expression during all progression stages suggested that a threshold level of the t antigen oncoprotein might be deterministic for beta-cell hyperproliferation and led us to hypothesize that tag might not be fully inhibiting the tumor suppressor activity of rb. moreover ... | 2005 | 16007165 |
| epidemiological study in okinawa, japan, of human papillomavirus infection of the uterine cervix. | to investigate the prevalence and type distribution of human papillomavirus (hpv) in women with normal cervical cytology and with cervical intraepithelial neoplasia i to iii(cin) or carcinoma of the cervix in okinawa, japan. | 2005 | 16011997 |
| knowledge of cervical cancer and screening among women in east-central england. | this study assesses the extent and accuracy of women's knowledge of cervical cancer, risk factors, and the efficacy of the national screening program. data were obtained from a questionnaire survey of randomly selected women eligible for screening, drawn from a population in east-central england. the majority of women in the sample overestimated the current incidence of cervical cancer, both absolutely and relative to other cancers. perceiving incidence to be high was associated with reporting w ... | 2005 | 16014118 |
| [relations between the expression of cyclin e, p16ink4, ki67 and hpv16/18 infection in cervical exfoliated cells]. | to confirm the relations between the expression of cyclin e, p16ink4, ki67 and hpv16/18 infection using cervical exfoliated cells, and evaluate the usefulness of cyclin e, p16ink4 and ki67 as biomarkers for screening of cervical carcinomas. | 2005 | 16027780 |
| laser capture microdissection and pcr for analysis of human papilloma virus infection. | human papilloma virus (hpv) infection is considered one of the main factors involved in the pathogenesis of endocervical adenocarcinoma. however, the cellular location of hpv in this type of tumor is controversial. we have developed a method to determine the presence of hpv type 16 in endocervical cancer cells using laser capture microdissection followed by dna extraction and qualitative polymerase chain reaction. our results show that hpv type 16 is present in endocervical adenocarcinoma cells. | 2005 | 16028428 |
| human papillomavirus type 16 infections and 2-year absolute risk of cervical precancer in women with equivocal or mild cytologic abnormalities. | the 2-year absolute risk for cervical precancer attributable to infection by human papillomavirus type 16 (hpv16), the most common and oncogenic hpv type, in the millions of women diagnosed annually with equivocal or mildly abnormal cytology has not been definitively evaluated. | 2005 | 16030304 |
| the elevated 10-year risk of cervical precancer and cancer in women with human papillomavirus (hpv) type 16 or 18 and the possible utility of type-specific hpv testing in clinical practice. | human papillomavirus (hpv) types 16 and 18 cause 60%-70% of cervical cancer worldwide, and other hpv types cause virtually all remaining cases. pooled hpv testing for 13 oncogenic types, including hpv16 and 18, is currently used in clinical practice for triage of equivocal cytology and, in conjunction with pap tests, is an option for general screening among women 30 years of age and older. it is not clear to what extent individual identification of hpv16 or hpv18 as an adjunct to pooled oncogeni ... | 2005 | 16030305 |
| presence and type of oncogenic human papillomavirus in classic and in differentiated vulvar intraepithelial neoplasia and keratinizing vulvar squamous cell carcinoma. | the presence and type of oncogenic papillomavirus (hpv) in classic warty/basaloid vulvar intraepithelial neoplasia and in differentiated vulvar intraepithelial neoplasia and keratinizing vulvar squamous cell carcinoma was investigated using three techniques, that is, histology, in situ hybridization, and pcr-elisa. hpv typing was performed using in situ hybridization and pcr-elisa. differentiated vulvar intraepithelial neoplasia and invasive keratinizing vulvar squamous cell carcinoma proved com ... | 2005 | 16032717 |
| candidate human papillomavirus (hpv) type 27b: nucleotide sequence and heterogeneity with hpv 27. | more than 100 human papillomavirus (hpv) types have been reported as tumorigenic agents. hpv types 2 and 27 were identified in benign tumors and classified closely according to the sequence homology. an hpv type 2 related sequence was identified previously in an oral papilloma. however, the correct typing and sequencing was impossible at that time. a candidate hpv was cloned by the long-pcr technique from an oral papilloma and characterized by nucleotide sequence. this virus was basically hpv ty ... | 2005 | 16032718 |
| detection of human papillomavirus (hpv) 16-specific cd4+ t-cell immunity in patients with persistent hpv16-induced vulvar intraepithelial neoplasia in relation to clinical impact of imiquimod treatment. | topical application of the immune response modifier imiquimod is an alternative approach for the treatment of human papillomavirus (hpv)-positive vulvar intraepithelial neoplasia (vin) and aims at the immunologic eradication of hpv-infected cells. we have charted hpv16-specific immunity in 29 patients with high-grade vin and examined its role in the clinical effect of imiquimod treatment. | 2005 | 16033846 |
| activation of the protein kinase b pathway by the hpv-16 e7 oncoprotein occurs through a mechanism involving interaction with pp2a. | protein kinase b (pkb) or akt is one of several second messenger kinases that are activated by cell attachment and growth factor signaling, and that transmit signals to the cell nucleus to inhibit apoptosis and thereby increase cell survival during proliferation. other viral proteins target this pathway by increasing pkb/akt phosphorylation, and this pathway has been implicated in the transformation of human keratinocytes by hpv e6 and e7, together with activated notch 1. here, we examine how hp ... | 2005 | 16044149 |
| hpv infection in adolescents: natural history, complications, and indicators for viral typing. | human papillomavirus (hpv) is the most common sexually transmitted disease in both men and women. prevalence rates are the highest for adolescents. despite the high prevalence rates, sequelae of genital warts, dysplasia, and cancer are rare developments. knowledge about the natural history, virology, and cancerous transformation has lead to improved viral detection, including the use of hpv dna detection tests, screening efforts for hpv-related precancerous and cancerous lesions, and clinical in ... | 2005 | 16044390 |
| proposed sheffield quantitative criteria in cervical cytology to assist the grading of squamous cell dyskaryosis, as the british society for clinical cytology definitions require amendment. | in 1986, the british society for clinical cytology (bscc) published quantitative criteria to assist diagnosis in a three-tier grading system of squamous cell dyskaryosis. in dyskaryotic cells, area nuclear to cytoplasmic (nc) ratios below 50%, between 50% and 66% and over 66% were defined as equating with mild, moderate and severe grades respectively. following the terminology conference in 2002, however, the bscc recommended on their website that the three-tier model should be replaced by a new ... | 2005 | 16048504 |
| simultaneous human papillomavirus 6 (hpv 6) -positive condyloma acuminatum, hpv 31-positive bowen's disease, and non hpv-associated extramammary paget's disease coexisting within an area presenting clinically as condyloma acuminatum. | an 83-year-old japanese man presented with multiple verrucous papules clustering on a plaque located on the frontal aspect of the scrotum. histologically, there were three distinct epithelial changes compatible with condyloma acuminatum, bowen's disease, and extramammary paget's disease (empd). by in situ hybridization, the zone of condyloma acuminatum was positive for hpv 6 and well demarcated from hpv 31-positive bowen's disease. empd was negative for targeted hpv 6/11/16/18/31/33 probes. immu ... | 2005 | 16148417 |
| pityrosporum and seborrheic keratosis: an association. | seborrheic keratoses (sk) are one of the most common benign tumors of the skin. studies have suggested that human papillomavirus or a benign clonal proliferation of epidermal cells is involved in the pathogenesis of some sk's, however, this issue remains to be resolved. pityrosporum ovale has been implicated in the pathogenesis of seborrheic dermatitis, however, its potential role in association with sk's has not been evaluated as evidenced by the fact that there are no publications in the engli ... | 2005 | 16150211 |
| screening for cervical cancer in the developing world. | cervical cancer remains the most common malignancy amongst females in countries of low income, mainly due to a lack of screening. responsible factors are centred around inadequacies of the pap smear: high cost; low sensitivity; the need of a laboratory with high human expertise; and a demanding logistic system for mass screening. no alternative screening method seems to be clearly advantageous. although combinations of tests have higher sensitivities, they are complex, costly and associated with ... | 2005 | 16150391 |
| knowledge of cervical dysplasia and human papillomavirus among women seen in a colposcopy clinic. | this study was undertaken to evaluate knowledge of cervical dysplasia and human papillomavirus (hpv) among women seen in a colposcopy clinic. | 2005 | 16150483 |
| [detection of telomerase activity in cervical lesions by non-radioactive telomeric repeat amplification protocol (trap)]. | worldwide, the cervical cancer is recognized as the second most common type or malignancy in women. the implementation of the papanicolaou smear has contributed notably to diminish its morbi-mortality. however, this test has a sensibility of just 80%. the detection of telomerase activity (ta) has been proposed as a diagnostic and prognostic maker of a wide variety of tumors and their precursor lesions. in this study the detection of ta was made from samples of cervical exfoliates and its associa ... | 2005 | 16152781 |
| association of human papillomavirus infection with palmoplantar epidermal cysts in korean patients. | human papillomavirus (hpv) infection can develop into many different kinds of diseases ranging from simple warts to carcinoma in situ. some investigators have recently suggested that hpv infection could be closely related to palmoplantar epidermal cysts. the aim of this study was to determine the existence of hpv and its subtype in palmoplantar epidermal cysts of korean patients. we investigated 13 cases of palmoplantar epidermal cysts by employing clinical, histopathological and immunohistochem ... | 2005 | 16159731 |
| synchronous cin 3 and cervical lymphoma: a case report and review of the literature. | primary cervical lymphoma is rare, with less than 60 cases reported in the english literature, including a few cases of synchronous cervical intraepithelial neoplasia (cin) with cervical lymphoma. we describe a 42-year-old woman with cin 3 and malignant lymphoma of the cervix. the papanicolaou cytology only revealed dysplastic cells of cin 3, but not the malignant lymphoid cells. the histology of the cervix revealed diffuse infiltration of monotonous medium-sized lymphoid cells with dispersing t ... | 2005 | 16164048 |
| two distinct activities contribute to human papillomavirus 16 e6's oncogenic potential. | high-risk human papillomaviruses, such as hpv16, cause cervical cancers, other anogenital cancers, and a subset of head and neck cancers. e6 and e7, two viral oncogenes expressed in these cancers, encode multifunctional proteins best known for their ability to bind and inactivate the tumor suppressors p53 and prb, respectively. in skin carcinogenesis experiments using e6 transgenic (k14e6(wt)) mice, hpv16 e6 was found to contribute to two distinct stages in skin carcinogenesis: promotion, a step ... | 2005 | 16166303 |
| characterization of the global profile of genes expressed in cervical epithelium by serial analysis of gene expression (sage). | serial analysis of gene expression (sage) is a new technique that allows a detailed and profound quantitative and qualitative knowledge of gene expression profile, without previous knowledge of sequence of analyzed genes. we carried out a modification of sage methodology (microsage), useful for the analysis of limited quantities of tissue samples, on normal human cervical tissue obtained from a donor without histopathological lesions. cervical epithelium is constituted mainly by cervical keratin ... | 2005 | 16171524 |
| incidence trends of adenocarcinoma of the cervix in 13 european countries. | rapid increases in cervical adenocarcinoma incidence have been observed in western countries in recent decades. postulated explanations include an increasing specificity of subtype-the capability to diagnose the disease, an inability of cytologic screening to reduce adenocarcinoma, and heterogeneity in cofactors related to persistent human papillomavirus infection. this study examines the possible contribution of these factors in relation with trends observed in europe. age-period-cohort models ... | 2005 | 16172231 |
| human papillomavirus infection: biology, epidemiology, and prevention. | over the past several decades, knowledge of the biology and epidemiology of human papillomavirus (hpv) infection has increased tremendously. however, there are still many unanswered questions concerning the interaction of the virus with its host. the virus has been identified as a necessary causal agent for cervical squamous neoplasia and has been linked to the development of neoplasia in several other mucosal sites. the viral oncogenes e6 and e7 are the major players in the virus' scheme to eva ... | 2005 | 16174218 |
| pseudoinfiltrative tubal metaplasia of the endocervix: a potential form of in utero diethylstilbestrol exposure-related adenosis simulating minimal deviation adenocarcinoma. | we report three cases of unusual tubal-type endocervical glandular proliferations simulating minimal deviation adenocarcinoma in women with a history of in utero diethylstilbestrol (des) exposure. the lesions were characterized by haphazard glandular proliferations extending from 3.4 to 6.1 mm into the endocervical stroma and to the margins of excision in all cases. most of the glands were small to medium-sized and round; some exhibited a moderate degree of cystic dilatation, and occasional glan ... | 2005 | 16175088 |
| human papillomavirus 16 minor capsid protein l2 helps capsomeres assemble independently of intercapsomeric disulfide bonding. | the human papillomavirus (hpv) capsomeres (pentamers of major capsid protein l1), which constitute along with l2 the virion capsid, can assemble themselves alone into the l1-capsid particles in vivo and in vitro, depending on intercapsomeric disulfide bonds. to study a possible role of l2 in capsid assembly, we examined the interaction between hpv16 l2 and capsomeres under the conditions that inhibit the formation of disulfide bonds in vitro and in vivo. the purified l2 bound to free capsomeres ... | 2005 | 16175337 |
| correlation between deoxyribonucleic acid loads of human papillomavirus and recurrence of condylomata acuminata. | to determine the correlation between deoxyribonucleic acid (dna) loads of human papillomavirus (hpv) and recurrence of condylomata acuminata (ca), 31 cases of primary ca and 32 cases of recurrent ca were assayed for the hpv6/11 and hpv16/18 dna loads by real-time fluorogenic quantitative pcr. the results showed 62 of the 63 cases were hpv6/11 dna positive (98.4%). the ranges of hpv6/11 dna contained in primary and recurrent ca were 1.4 x 10(3)-6.7 x 10(7) and 1.2 x 10(4)-3.6 x 10(8) copies/ml, r ... | 2005 | 16176626 |
| [inverted naso-sinusal papilloma: analytic study on 13 cases]. | inverted nasosinusal papilloma is a rare tumorous process involving mucosa of nasal fossa and paranasal sinus unilaterally. the authors studied inverted naso-sinusal papilloma observed and treated in ent and head and neck department at brazzaville university hospital. | 2005 | 16180352 |
| human papillomavirus type and tobacco use as predictors of survival in early stage cervical carcinoma. | molecular and environmental co-factors are known risk factors for cervical cancer. the aim of this study was to define the prognostic significance of hpv 18 and its phylogenetically related viruses and smoking on survival in patients with early stage cervical cancer. | 2005 | 15894364 |
| psychosocial factors and the course of cervical intra-epithelial neoplasia: a prospective study. | to investigate the influence of psychosocial factors on the course of cervical intra-epithelial neoplasia (cin). | 2005 | 15894367 |
| modifiable risk factors associated with clearance of type-specific cervical human papillomavirus infections in a cohort of university students. | previous findings regarding risk factors for human papillomavirus (hpv) persistence, other than viral determinants, identified from prospective cohort studies have been inconsistent in part because study designs have differed with respect to differing hpv detection methods and varying lengths of follow-up time. therefore, the objectives of this study were to continue the search for epidemiologic risk factors of persistent cervical hpv infections and determine what behaviors differed between thos ... | 2005 | 15894665 |
| synchronous invasive squamous cell carcinoma and clear cell adenocarcinoma of the uterine cervix: a different human papillomavirus status. | a multiple primary invasive carcinoma of the cervix is a rare condition and is seldom composed of squamous cell carcinoma and clear cell adenocarcinoma. | 2005 | 15896829 |
| prevalence of types 16 and 33 is increased in high-risk human papillomavirus positive women with cervical intraepithelial neoplasia grade 2 or worse. | high-risk human papillomavirus (hrhpv) types are causally related to cervical cancer and its high-grade precursor lesions. the risk posed by the different hrhpv types for the development of cervical intraepithelial neoplasia grade 2 or worse (> or =cin2) needs to be established. here, we present the hrhpv type-distribution in relation to cytology and histology for women participating in a cervical screening program. from 44,102 women who participated in a population-based cervical screening prog ... | 2005 | 15900579 |
| human papillomavirus genotypes and the p53 codon 72 polymorphism in cervical cancer of northeastern thailand. | human papillomavirus (hpv) infection including sub-strain identification was studied in patients with squamous cell cervical cancer (scca) in northeastern thailand. subjects were 90 cases of scca and 100 healthy controls. prevalence of high-risk group of hpv infection in the controls and the scca patients were 13.0% and 86.7%, respectively. the hpv infection significantly increased the risk for cervical cancer 43.5-fold (95% confidential interval: 17.5-110.6; p <0.00001). among hpv carrier patie ... | 2005 | 15905603 |
| comparison between in situ hybridization and real-time pcr technique as a means of detecting the integrated form of human papillomavirus 16 in cervical neoplasia. | integration of the human papillomavirus (hpv) genome is thought to be one of the causes of cancer progression. however, there is controversy concerning the physical status of hpv 16 in premalignant cervical lesions, and there have been no reports on the concordance between detection of the integrated form of hpv16 by real-time pcr and by in situ hybridization. we investigated specimens of cervical intraepithelial neoplasia (cin) and invasive carcinomas for the physical status of hpv 16 by real-t ... | 2005 | 15905694 |
| methylation of human papillomavirus genomes in cells of anal epithelia of hiv-infected men. | intra-anal malignancies disproportionately affect individuals who engage in anal intercourse because of infection with human papillomaviruses (hpvs), with an increased risk attributed to infection with hiv because of a declining immunity against hpvs. long-term persistence of hpvs suggests yet other mechanisms that determine the clinical outcome, however. because methylation of hpv dna represses oncogene expression in cervical samples, we investigated whether this mechanism also occurs in hiv-po ... | 2005 | 15905729 |
| disruption of p53 by the viral oncoprotein hpv16-e6 does not deregulate chromosomal homologous recombination in a transcriptional interference-free assay system. | in addition to its well established role in the maintenance of genome integrity by regulating transcription of genes involved in cell cycle arrest and programmed cell death, the tumour suppressor p53 has also been shown to inhibit spontaneous chromosomal homologous recombination (hr) between adjacent transcription units, raising the possibility that p53 may prevent chromosomal rearrangements by suppressing hr between repetitive dna elements (ectopic hr). consistent with its role in the maintenan ... | 2005 | 15908792 |
| human papilloma virus and breast cancer. | 2005 | 15911436 | |
| the role of diet and nutrition in cervical carcinogenesis: a review of recent evidence. | our objective was to provide an update on recent epidemiologic evidence about the role of diet and nutrition on the risk of human papillomavirus (hpv) persistence and cervical neoplasia, taking hpv into account. we conducted a systematic review and qualitative classification of all observational studies controlling for hpv infection published between march 1995 and november 2003 and of all randomized clinical trials published between january 1991 and november 2003. scientific evidence was classi ... | 2005 | 15912536 |
| [immunomodulatory treatment with beta-interferon in patients with cervical intraepithelial neoplasia and human papillomavirus infection: long-term follow-up]. | the aim of this study was to evaluate the long-term efficacy of beta-interferon treatment in the management of cervical intraepithelial neoplasia associated with human papillomavirus (hpv) infection in a selected group of patients. thirty-nine patients who had histologically proven cervical intraepithelial neoplasia i or ii with concurrent hpv infection were administered 27,000,000 iu of intramuscular beta-interferon. periodical controls were carried out based on papanicolaou smears and/or colpo ... | 2005 | 15915229 |
| preliminary evaluation of a cervical self-sampling device with liquid-based cytology and multiparameter molecular testing. | to compare the collection of a liquid-based cell sample using a cervical self-sampling device and traditional sampling using cytologic and molecular-based tests. | 2005 | 15916209 |
| involvement of nuclear export in human papillomavirus type 18 e6-mediated ubiquitination and degradation of p53. | the e6 protein from high-risk human papillomaviruses (hpvs) targets the p53 tumor suppressor for degradation by the proteasome pathway. this ability contributes to the oncogenic potential of these viruses. however, several aspects concerning the mechanism of e6-mediated p53 degradation at the cellular level remain to be clarified. this study therefore examined the role of cell localization and ubiquitination in the e6-mediated degradation of p53. as demonstrated within, following coexpression bo ... | 2005 | 15994771 |
| [the association of hela cell apoptosis induced by arsenic trioxide with the down-regulation of hpv18 e6 oncogene and inhibition of telomerase activity]. | to study the effect of as2o3 induction of hela cell apoptosis on hpv18 e6 expression and telomerase activity. | 2005 | 15996315 |
| [assessment of human papilloma virus (hpv) testing in primary screening for cervical cancer in france (may 2004)]. | 2005 | 15999430 | |
| synchronous and metachronous endocervical and ovarian neoplasms: evidence supporting interpretation of the ovarian neoplasms as metastatic endocervical adenocarcinomas simulating primary ovarian surface epithelial neoplasms. | the vast majority of endocervical adenocarcinomas are high-risk human papillomavirus (hpv)-related neoplasms, characterized by p16 expression and frequent loss of hormone receptor expression, which infrequently metastasize to the ovaries. we report 10 cases of endocervical adenocarcinomas with ovarian metastases in which the ovarian tumors simulated primary ovarian surface epithelial neoplasms. the presence of hpv dna was assessed to determine whether the ovarian neoplasms were metastases or ind ... | 2005 | 15725796 |
| genetic analysis of the human papillomavirus type 31 differentiation-dependent late promoter. | human papillomaviruses infect stratifying squamous epithelia, causing benign and malignant lesions. upon differentiation of the host keratinocyte, the virus undergoes a dramatic increase in both dna replication and transcription from the late promoter, leading to expression of late genes and virion morphogenesis. in human papillomavirus type 31 (hpv31), the late promoter is designated p742 and includes multiple start sites embedded within the e7 gene. in this report, we mapped viral dna elements ... | 2005 | 15731225 |
| medication use, medical conditions, and the risk of human papillomavirus infection and subsequent cervical intraepithelial neoplasia 3 among women with mild cytologic abnormalities. | 2005 | 15734987 | |
| generation and molecular characterization of head and neck squamous cell lines of fanconi anemia patients. | patients with fanconi anemia (fa) are prone to develop malignancies at an early age. besides hematologic malignancies, squamous cell carcinomas in the anogenital region and head and neck are also frequently found in these patients. the aim of this study was to generate a panel of head and neck squamous cell carcinoma (hnscc) cell lines and xenografts of fa hnscc, and to characterize these cell lines in comparison with a panel of seven cell lines from patients with sporadic hnscc. analyses have b ... | 2005 | 15735012 |
| development of skin tumors in mice transgenic for early genes of human papillomavirus type 8. | the cutaneous human papillomavirus (hpv) 8 is clearly involved in skin cancer development in epidermodysplasia verruciformis patients and its early genes e2, e6, and e7 have been implicated in cell transformation in vitro. to examine the functions of these genes in vivo we integrated the complete early region of hpv8 into the genome of dba/bl6 mice. to target their expression to the basal layer of the squamous epithelia the transgenes were put under the control of the keratin-14 promoter. transg ... | 2005 | 15735026 |
| hpv16 e5 protein disrupts the c-cbl-egfr interaction and egfr ubiquitination in human foreskin keratinocytes. | the e5 protein of human papillomavirus type 16 (hpv16) is a small hydrophobic protein, which localizes to the cell membrane, golgi apparatus and endosomes. hpv16 e5 enhances the activation of the epidermal growth factor (egfr). the activated egfr is downregulated through the endocytic pathway, where e5 has been shown to inhibit endosomal acidification and trafficking. ubiquitination of the activated egfr plays a role in this downregulation. c-cbl is a ubiquitin ligase that associates with the ac ... | 2005 | 15735736 |
| trail is a key target in s-phase slowing-dependent apoptosis induced by interferon-beta in cervical carcinoma cells. | interferon (ifn)-beta induces s-phase slowing and apoptosis in human papilloma virus (hpv)-positive cervical carcinoma cell line me-180. here, we show that apoptosis is a consequence of the s-phase lengthening imposed by ifn-beta, demonstrating the functional correlation between s-phase alteration and apoptosis induction. in me-180 cells, where p53 function is inhibited by hpv e6 oncoprotein, ifn-beta effects on cell cycle and apoptosis occur independently of p53. the apoptosis due to ifn-beta i ... | 2005 | 15735750 |
| p53 intronic g13964c variant in colon cancer and its association with hpv. | inactivation of p53 is the most common change identified in human cancer. nucleotide alterations in p53 intron 6 have been reported to be associated with the dysregulation of p53 function and tumor development. the aim of our study was to assess whether the intron 6 g13964c variant of the p53 gene is associated with the presence of human papillomavirus (hpv) as a risk factor in colon cancer. | 2005 | 16080524 |
| the biological role of smoking, oral contraceptive use and endogenous sexual steroid hormones in invasive squamous epithelial cervical cancer. | for at least twenty years, epidemiological studies have found a correlation between cervical neoplasia and smoking and oral contraceptives. over the last ten years, laboratory evidence has supported epidemiological findings. one example is the addition of progesterone to human papillomavirus-transfected cervical cells, which has led to oncogenic cell transformation. very high concentrations of tobacco constituents in cervical mucus, as compared to serum, in smokers provided evidence of a biologi ... | 2005 | 16080563 |
| expression of human papillomavirus type 16 l1 in baculovirus expression systems: a case study. | 2005 | 16082027 | |
| optimization and validation of a multiplexed luminex assay to quantify antibodies to neutralizing epitopes on human papillomaviruses 6, 11, 16, and 18. | a human papillomavirus (hpv) multiplexed competitive luminex immunoassay first described by opalka et al. (d. opalka, c. e. lachman, s. a. macmullen, k. u. jansen, j. f. smith, n. chirmule, and m. t. esser, clin. diagn. lab. immunol. 10:108--15, 2003) was optimized and validated for use in epidemiology studies and vaccine clinical trials. optimization increased both the analytical sensitivity and the clinical specificity of the assay to more effectively discriminate the low-titer antibody respon ... | 2005 | 16085914 |
| human papilloma virus papilloma masquerading as adenoid hypertrophy. | 2005 | 16087035 | |
| human papillomavirus-related cervical and anal disease in hiv-infected individuals in the era of highly active antiretroviral therapy. | hiv-infected men who have sex with men remain at high risk of developing anal cancer despite the widespread use of highly active antiretroviral therapy (haart). in hiv-infected women, however, there is some evidence that haart may be associated with regression of human papillomavirus (hpv)-related cervical disease. so far, epidemiologic data provided by cancer registries have shown no reduction in the incidence of cervical and anal cancer in patients with hiv infection since the initiation of ha ... | 2005 | 16091261 |
| aerodigestive cancers in hiv infection. | aerodigestive (lung, head and neck) cancers are among the most prevalent and deadly neoplasms worldwide, and the incidence rates are rising. given the improvements in life expectancy of persons with hiv/aids when treated with highly active antiretroviral agents, persons with hiv infection are therefore increasingly likely to develop these malignancies. this chapter focuses on the epidemiology of these malignancies and reviews the most recent literature and current understanding of the causes and ... | 2005 | 16093799 |
| the utility of hpv dna triage in the management of cytological agc. | given the demonstrated utility of human papilloma virus dna triage in the management of atypical squamous cells of undetermined significance, this study sought to evaluate the potential role of human papilloma virus dna testing in the evaluation and management of cytological atypical glandular cells. | 2005 | 16098895 |
| differential splicing of e6 within human papillomavirus type 18 variants and functional consequences. | persistent infections of the uterine cervix with 'high-risk' human papillomavirus (hpv) are now recognized as necessary for the development of cervical cancer. among them, hpv types 16 and 18 exhibit numerous variants associated with different risks for cervical cancer development. in this study, the questions of whether different hpv type 18 variants exhibit changes in early gene transcription and the molecular mechanisms underlying these differences were investigated. it was shown that, indeed ... | 2005 | 16099904 |
| loss of 10p material in a child with human papillomavirus-positive disseminated bilateral retinoblastoma. | retinoblastoma (rb) is a malignant childhood tumor that results from loss or inactivation of both alleles of the rb1 gene. human papillomavirus (hpv) dna sequences have been found in rb tissue, suggesting a role of the viral infection with rb. we here describe a child with disseminated bilateral rb without familial history, who displayed a loss of material from 10p. fluorescence in situ hybridization studies showed a somatic loss of both alleles of the rb1 gene. moreover, sequences for hpv-6a we ... | 2005 | 16102585 |
| [evaluation of search for human papillomavirus (hpv) during cervical precancer and cancer screening: synopsis and perspectives (may 2004)]. | 2005 | 16108114 | |
| parental acceptance of the human papillomavirus vaccine. | we conducted focus groups and individual interviews to explore parental views on the human papillomavirus (hpv) vaccine. parents were generally positive about the hpv vaccine. some participants perceived their children were not at risk for acquiring hpv and questioned vaccinating young adolescents against hpv. vaccine education should target parental beliefs about hpv and the optimal age for hpv vaccine administration. | 2005 | 16109349 |
| immunotherapy with ctl peptide and vssp eradicated established human papillomavirus (hpv) type 16 e7-expressing tumors. | peptide-based vaccines aimed at the induction of effective t-cell responses against established tumors have not been successful in clinic and require the use of new adjuvants. one of those is a new adjuvant in which gangliosides are incorporated into the outer membrane protein complex of neisseria meningitidis to form very small size proteoliposomes (vssp). in a preclinical model of human papillomavirus hpv16-induced cervical cancer we show that vaccination with hpv 16 e7 derived minimal ctl pep ... | 2005 | 16112257 |
| tissue distribution of human papillomavirus 16 dna integration in patients with tonsillar carcinoma. | human papillomavirus 16 (hpv-16) has been implicated as a causative agent in a subset of head and neck squamous cell carcinomas (hnscc). this study was undertaken to discern the distribution and timing of hpv viral integration during tumorigenesis of the upper respiratory tract. | 2005 | 16115905 |
| profiling estrogen-regulated gene expression changes in normal and malignant human ovarian surface epithelial cells. | estrogens regulate normal ovarian surface epithelium (ose) cell functions but also affect epithelial ovarian cancer (oca) development. little is known about how estrogens play such opposing roles. transcriptional profiling using a cdna microarray containing 2400 named genes identified 155 genes whose expression was altered by estradiol-17beta (e2) in three immortalized normal human ovarian surface epithelial (hose) cell lines and 315 genes whose expression was affected by the hormone in three es ... | 2005 | 16116479 |
| immunotherapy for gynaecological malignancies. | gynaecological malignancies, excluding breast cancer, cause approximately 25,000 deaths yearly among women in the us. therefore, novel approaches for the prevention or treatment of these diseases are urgently required. in the case of cervical cancer, human papillomavirus (hpv) xenoantigens are readily recognised by the immune system, and their targeting has shown great promise in preclinical models of therapeutic vaccination and in clinical studies of preventative vaccination. a growing body of ... | 2005 | 16120050 |
| epidemiologic correlates of cervical human papillomavirus prevalence in women with abnormal pap smear tests: a taiwan cooperative oncology group (tcog) study. | to explore factors affecting human papillomavirus (hpv) prevalence in all grades of cervical neoplasia among chinese women, 1,264 women with abnormal cervical cytology attending the gynaecologic clinics of 11 major medical centres in taiwan. patients were interviewed and underwent complete gynaecologic examination including colposcopy. cervical scrapings were collected for hpv dna detection by both hybrid capture-2 (high-risk probe) and l1 consensus pcr-reverse line blot. the prevalences of hpv ... | 2005 | 16121376 |
| the p53 codon 72 polymorphism and risk of high-grade cervical intraepithelial neoplasia. | the arg/arg genotype versus arg/pro or pro/pro at codon 72 of the p53 gene has been implicated in increasing susceptibility of the cervix to human papillomavirus (hpv) infection and thus altering cancer risk. however, research on this topic has been contentious, which prompted us to carry out a case-control study in the montreal area. | 2005 | 16122882 |
| p53 mutations and human papillomavirus infection in oral squamous cell carcinomas: correlation with overall survival. | the study investigated the pattern of p53 gene mutations and human papillomavirus (hpv) infection concerning their relation to overall survival in patients with oral squamous cell carcinomas of the tongue and floor of the mouth. | 2005 | 16129609 |
| a theoretical discussion of the impact of stigma on psychological adjustment to having a sexually transmissible infection. | this paper provides a discussion of the utility of stigma theory as a conceptual framework for the interpretation and analysis of the psychological impact of contracting a sexually transmissible infection (sti). most particularly, it focuses on those viral infections that cannot be medically cured, such as genital herpes and genital human papilloma virus. recent research in the area of stis suggests that the stigma associated with these conditions can hinder psychosocial and sexual adjustment po ... | 2005 | 16335743 |
| human papillomavirus: burden of illness and treatment cost considerations. | the monetary and personal costs to society of human papillomavirus (hpv) infection are enormous. in order to make a comparison of different treatment methods we reviewed the entire literature on hpv treatment from january 1966 to december 2003 using medline, with particular reference to published meta-analyses, randomized controlled and comparative studies. patient-applied therapies offer patients the possibility of convenient and, on the whole, pain-free treatment. podofilox (podophyllotoxin) a ... | 2005 | 16343025 |
| [efficacy and safety of 5% imiquimod cream in external genital warts: a 6 month follow-up evaluation]. | one of the main issues raised by the management of external genital warts is their potential risk of recurrence. however, nearly all studies assessing recurrences have been conducted with a 3 month follow-up. since the latency of the human papillomavirus is long, such 3 month follow-up might be too short to detect the true recurrence rate. we therefore conducted a study evaluating patients with external genital warts, treated with an immune response modifier, 5% imiquimod cream, and followed up ... | 2005 | 16327713 |
| high prevalence of human papillomavirus infections in urine samples from human immunodeficiency virus-infected men. | infection with human immunodeficiency virus (hiv) and the resulting immunosuppression are associated with an increased risk for human papillomavirus (hpv) persistence and related malignancies. in the present study we investigated the prevalence of hpv in urine samples from 104 hiv-infected men with low cd4+ cell counts (<100 per mm(3)) and 115 urine samples from hiv-negative men. a high prevalence of hpv dna (39.4%) was found in the hiv patients. most of the hpv types were high risk (81.4%), wit ... | 2005 | 16333078 |
| risk factors in oral and oropharyngeal squamous cell carcinoma: a population-based case-control study in southern sweden. | in the year 2002, about 275,000 inhabitants around the world developed oral cancer and over half of them will die of their disease within 5 years. oral and oropharyngeal squamous cell carcinoma (ooscc) accounts for about 1% of all cancers in sweden - which is low compared to the incidence on the indian subcontinent and in other parts of asia, where it is one of the most common forms of cancer. the incidence in sweden is increasing, however. the study comprised 80% (132/165) of all consecutive ca ... | 2005 | 16335030 |
| a novel mucosal vaccine based on live lactococci expressing e7 antigen and il-12 induces systemic and mucosal immune responses and protects mice against human papillomavirus type 16-induced tumors. | current strategies to prevent or treat human papillomavirus type 16 (hpv-16) infection are promising, but remain costly. more economical but efficient vaccines are thus needed. in this study, we evaluated the protective effects of mucosally coadministered live lactococcus lactis strains expressing cell wall-anchored e7 ag and a secreted form of il-12 to treat hpv-16-induced tumors in a murine model. when challenged with lethal levels of tumor cell line tc-1 expressing e7, immunized mice showed f ... | 2005 | 16301635 |
| self-sampling versus physician-sampling for human papillomavirus testing. | we evaluated the detection of human papillomavirus (hpv) infection using two sampling methods of cervical exfoliated cells, consisting of self-sampling of vaginal cells and cervical sampling performed by the physician. women included were 379 patients of the general population attending outpatient clinics in northern greece for routine cytological cervical dysplasia screening. hpv dna detection was similar with both sampling techniques. the hpv prevalences in self-collected samples were 4.7% and ... | 2005 | 16303065 |
| vaccination as a prevention strategy for human papillomavirus-related diseases. | childhood vaccines have had an enormously beneficial impact on human health. large-scale vaccination programs have controlled diseases associated with high morbidity and mortality such as poliomyelitis, smallpox, diphtheria, tetanus, yellow fever, pertussis, haemophilus influenzae, streptococcus pneumoniae, measles, mumps, and rubella. human papillomavirus (hpv) is a significant source of morbidity and mortality throughout the world. in the united states, hpv is the most common sexually transmit ... | 2005 | 16310136 |
| interaction among folate, riboflavin, genotype, and cancer, with reference to colorectal and cervical cancer. | epidemiological studies have linked low folate intake with an increased risk of epithelial cancers, including colorectal cancer and cervical cancer. riboflavin has received much less attention, but there is increasing interest in the well-established role that flavins play in folate metabolism and the possible synergy of a protective effect between these 2 vitamins. folate plays a key role in dna synthesis, repair, and methylation, and this forms the basis of mechanistic explanations for a putat ... | 2005 | 16317155 |
| cervical human papillomavirus screening among older women. | rates of acquisition and clearance of cervical human papillomavirus (hpv) during a 3-year period in women 51 years of age were compared with rates in younger women to provide data on cervical screening for women >50 years of age. paired, cytologically negative, archived cervical smears taken 3 years apart from 710 women in nottingham, united kingdom, were retrieved and tested for hpv infection with polymerase chain reaction (pcr) with gp5+/6+ primers. seventy-one (21.3%) of 333 women 51 years of ... | 2005 | 16318718 |
| dihydroartemisinin is cytotoxic to papillomavirus-expressing epithelial cells in vitro and in vivo. | nearly all cervical cancers are etiologically attributable to human papillomavirus (hpv) infection and pharmaceutical treatments targeting hpv-infected cells would be of great medical benefit. because many neoplastic cells (including cervical cancer cells) overexpress the transferrin receptor to increase their iron uptake, we hypothesized that iron-dependent, antimalarial drugs such as artemisinin might prove useful in treating hpv-infected or transformed cells. we tested three different artemis ... | 2005 | 16322232 |
| identification of hpv variants. | the vast majority of anogenital carcinomas are caused by high-risk human papillomaviruses (hpvs), and among western nations hpv-16 is usually the most predominant cancer-associated type. as a dna virus, hpv type 16 has a relatively stable genome that is believed to have co-evolved with its host over the millennia. nevertheless, among the "wild" populations of hpv-16 that are circulating, a large number of variants have been identified, and these may have considerably different pathogenic potenti ... | 2005 | 16350393 |
| histological analysis of cervical intraepithelial neoplasia. | a wide interobserver variation is seen even among competent histopathologists in the routine diagnosis of cervical intraepithelial neoplasia (cin). as a result, early detection of low-grade cin (cin 1) lesions, in particular, remains a major challenge both in routine diagnosis and in cervical screening. in this chapter, the salient diagnostic features of human papillomavirus infection and cin lesions are demonstrated. | 2005 | 16350395 |