Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| seasonal variation in the incidence of late-onset bleb-related infection after filtering surgery in japan: the japan glaucoma society survey of bleb-related infection report 3. | to investigate seasonal variations in the incidence of late-onset bleb-related infection after filtering surgery in japan and the relationship between season and other factors. | 2016 | 26550963 |
| a 15-year retrospective analysis of prognostic factors in childhood bacterial meningitis. | this retrospective chart review aimed to identify factors in childhood bacterial meningitis that predicted disease severity and long-term outcome. | 2016 | 26426265 |
| association of low b cell count and igg levels with infection, and poor vaccine response with all-cause mortality in an immunosuppressed vasculitis population. | patients with systemic vasculitis (sv) have an increased risk of all-cause mortality, often due to infection, compared to the healthy population. we investigated whether humoral response to vaccination and biomarkers of immune dysfunction were associated with infection and death. | 2016 | 26474373 |
| analysis of non-typeable haemophilus influenzae in invasive disease reveals lack of the capsule locus. | among invasive haemophilus influenzae, unencapsulated strains have largely surpassed the previously predominant serotype b (hib) because of hib vaccination. isolates without the genomic capsule (cap) locus are designated non-typeable h. influenzae (nthi). they are different from capsule-deficient variants that show deletion of the capsule transport gene bexa within the cap locus. the frequency of capsule-deficient variants in invasive disease is unknown. we analysed 783 unencapsulated invasive i ... | 2016 | 26454058 |
| analysis of the distribution and evolution of the atp-dependent dna ligases of bacteria delineates a distinct phylogenetic group 'lig e'. | prior to the discovery of a minimal atp-dependent dna ligase in haemophilus influenzae, bacteria were thought to only possess a nad-dependent ligase, which was involved in sealing of okazaki fragments. we now know that a diverse range of bacterial species possess up to six of these accessory bacterial atp-dependent dna ligases (b-adls), which vary in size and enzymatic domain associations. here we compare the domain structure of different types of b-adls and investigate their distribution among ... | 2016 | 26412580 |
| lack of evidence of increased risk of bacterial transmission during cystic fibrosis educational programmes. | educational and rehabilitation programmes increase the quality-of-life of patients with cystic fibrosis, but patients are discouraged to participate because of the risk of cross-infections. | 2016 | 26003901 |
| isolation of haemophilus influenzae and haemophilus parainfluenzae in urethral exudates from men with acute urethritis: a descriptive study of 52 cases. | to describe the clinical characteristics and therapeutic outcomes from male patients diagnosed of haemophilus spp urethritis. | 2016 | 26139207 |
| surveillance of the activity of aminoglycosides and fluoroquinolones against ophthalmic pathogens from europe in 2010-2011. | bacterial infections of the ocular surface are commonly treated empirically with broad spectrum antibiotics. due to concerns over increasing antibiotic resistance, we evaluated current susceptibility patterns of the ocular bacterial pathogens in europe. | 2016 | 26200173 |
| dentures are a reservoir for respiratory pathogens. | recent studies have established a relationship between dental plaque and pulmonary infection, particularly in elderly individuals. given that approximately one in five adults in the uk currently wears a denture, there remains a gap in our understanding of the direct implications of denture plaque on systemic health. the aim of this study was to undertake a comprehensive evaluation of putative respiratory pathogens residing upon dentures using a targeted quantitative molecular approach. | 2016 | 26260391 |
| vaccination coverage in french 17-year-old young adults: an assessment of mandatory and recommended vaccination statuses. | we aimed to assess vaccination coverage (vc) in 17-year-old french young adults (yas) participating in one mandatory day of defence and citizenship (ddc). between june 2010 and may 2011, yas participating in 43 randomly selected mandatory sessions of the ddc programme in poitou-charentes (france) were asked to provide their personal vaccination record. tetanus, diphtheria, polio, hepatitis b, haemophilus influenzae b, pertussis, measles, mumps and rubella vaccination status were assessed at ages ... | 2016 | 26159149 |
| ventilator-associated pneumonia in pediatric traumatic brain injury. | ventilator-associated pneumonia (vap) is a common occurrence among intubated pediatric traumatic brain injury (tbi) patients. however, little is known about the epidemiology, risk factors, and microbiology of vap in pediatric tbi. we reviewed a cohort of 119 pediatric moderate-to-severe tbi patients and identified 42 with vap by positive protected bronchial brush specimens. location of intubation, severity of injury, and antibiotic administration within 2 days after injury were not associated wi ... | 2016 | 26203702 |
| haemophilus influenzae strains possess variations in the global transcriptional profile in response to oxygen levels and this influences sensitivity to environmental stresses. | an alcohol dehydrogenase, adhc, is required for haemophilus influenzae rd kw20 growth with high oxygen. adhc protects against both exogenous and metabolically generated, endogenous reactive aldehydes. however, adhc in the strain 86-028np is a pseudogene. unlike the rd kw20 adhc mutant, 86-028np does grow with high oxygen. this suggests the differences between rd kw20 and 86-028np include broader pathways, such as for the maintenance of redox and metabolism that avoids the toxicity related to oxy ... | 2016 | 26362945 |
| impact of bacteria in nasal aspirates on disease severity of bronchiolitis. | the effect of potentially pathogenic bacteria (ppb) on disease severity in patients with bronchiolitis is understudied. | 2016 | 26365560 |
| epidemiology of invasive pneumococcal disease in saudi arabian children younger than 5years of age. | this study evaluated the incidence, serotype distribution, and antimicrobial susceptibility of invasive pneumococcal disease (ipd) in saudi arabian children. this multicenter, prospective, clinical surveillance study included children under 5years of age, residents of one of the seven study health areas, who were brought to a study hospital with suspicion of ipd. bacterial isolates from sterile site samples, collected less than 24h after hospital visit/admission, were identified, serotyped, and ... | 2016 | 26368823 |
| how a new health intervention affects the health systems? learnings from pentavalent vaccine introduction in india. | to summarize the findings from a post introduction evaluation (pie) of pentavalent vaccine in tamil nadu and kerala state of india and to understand how the health systems could be prepared for (prior to) introducing a new intervention and how such introduction could affect the health systems (afterwards). | 2016 | 26264631 |
| bacteremia following nasolacrimal duct probing: is there a role of preoperative antibiotic prophylaxis? | to study the incidence of nasolacrimal duct probing-induced bacteremia using the metabolic colorimetric sensor technique of blood culture. | 2016 | 25675170 |
| the first reported case of possible haemophilus influenzae type b vaccine failure from kuwait and literature-review. | a 17-month-old vaccinated kuwaiti boy presented with meningitis. the haemophilus influenzae type b (hib) capsular antigen was detected in his blood, csf and urine. the microorganism failed to grow in culture. this case represents the first report of possible hib vaccine failure from kuwait. this report examines the possible reasons for this failure by reviewing the literature and emphasizes the need to broaden the definition of vaccine failure with the aim of optimizing the timing of the vaccine ... | 2016 | 24216517 |
| toxicity of macrolide antibiotics on isolated heart mitochondria: a justification for their cardiotoxic adverse effect. | 1. macrolides belong to the polyketide class of natural products. these products are a group of drugs (typically antibiotics) which their activity stems from the presence of a macrolide ring. antibiotic macrolides are used to treat infections caused by gram-positive bacteria and haemophilus influenzae infections such as respiratory tract and soft-tissue infections. macrolides, mainly erythromycin and clarithromycin, rarely show qt prolongation, as their infamous adverse reaction which can lead t ... | 2016 | 26068526 |
| using monte carlo simulation to determine optimal dosing regimen for cefetamet sodium for injection. | the objective of the study was to use monte carlo simulation to determine the optimal treatment dosing regimen of the cefetamet sodium for injection by analysing the pharmacokinetics (pk) parameters in healthy chinese volunteers, and antibacterial activity in vitro was also examined. a three-cross latin square single-dose pk study was designed. twelve healthy volunteers were randomized to receive 500, 1000, and 2000 mg of cefetamet sodium for iv infusion over 30 minutes in three periods sequenti ... | 2016 | 25252727 |
| immunization status of children in foster homes: the first italian data. | the aim of this paper was to evaluate vaccination coverage among children living in forest homes. | 2016 | 24992472 |
| ocular penetration of topical antibiotics: study on the penetration of chloramphenicol, tobramycin and netilmicin into the anterior chamber after topical administration. | to compare penetration in the aqueous humour of topically applied antibiotics. | 2016 | 23433257 |
| meninigitis immunisation: challenges, successes and new developments. | meningitis, defined as the inflammation of the lining surrounding the spine and the brain, can be caused by bacteria, viruses and fungi. bacterial meningitis is the most serious form of the disease, causing around 170000 deaths worldwide each year. most cases of bacterial meningitis are caused by three bacteria-streptococcus pneumoniae, neisseria meningitidis and haemophilus influenzae type b. in the uk, vaccines are available to combat most of these, yet, according to the meningitis research fo ... | 2016 | 23299207 |
| [impact of vaccination on admissions for haemophilus influenzae b meningitis from 2004 to 2008 in bobo dioulasso, burkina faso]. | vaccination against haemophilus influenzae type b was introduced in burkina faso on 1st january 2006. this study thus sought to determine the impact of the first 30 months of vaccination on admissions for hib meningitis in the department of pediatrics at the sourô-sanou university hospital in bobo dioulasso. | 2016 | 23360620 |
| new south wales annual vaccine-preventable disease report, 2012. | we aim to describe the epidemiology of selected vaccine-preventable diseases in new south wales (nsw) for 2012. data from the nsw notifiable conditions information management system were analysed by: local health district of residence, age, aboriginality, vaccination status and organism, where available. risk factor and vaccination status data were collected by public health units for cases following notification under the nsw public health act 2010. the largest outbreak of measles since 1998 wa ... | 2017 | 25077033 |
| a rare case of ruptured infrarenal aortic aneurysm infected with haemophilus influenzae type b. | 2017 | 26600811 | |
| invasive disease due to haemophilus influenzae type a in children in canada's north: a priority for prevention. | 2017 | 26744583 | |
| safety profile of the 10-valent pneumococcal non-typeable haemophilus influenzae protein d conjugate vaccine (phid-cv). | safety and reactogenicity data were reviewed following 10 years of experience with the 10-valent pneumococcal non-typeable haemophilus influenzae protein d conjugate vaccine (phid-cv) in clinical development and from post-licensure settings. analyses of pooled clinical trial data and post-marketing reports provided an overview of its safety profile and allowed assessment of rare adverse events that might not have been identified previously. the safety of phid-cv was also evaluated in children at ... | 2017 | 26954689 |
| bacterial colonization and associated factors in patients with bronchiectasis. | to evaluate the bacterial colonization and associated risk factors in patients with bronchiectasis. | 2017 | 26933458 |
| microrna-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase-mediated suppression of histone deacetylase 2. | severe steroid-insensitive asthma is a substantial clinical problem. effective treatments are urgently required, however, their development is hampered by a lack of understanding of the mechanisms of disease pathogenesis. steroid-insensitive asthma is associated with respiratory tract infections and noneosinophilic endotypes, including neutrophilic forms of disease. however, steroid-insensitive patients with eosinophil-enriched inflammation have also been described. the mechanisms that underpin ... | 2017 | 27448447 |
| interleukin-22 protects against non-typeable haemophilus influenzae infection: alteration during chronic obstructive pulmonary disease. | chronic obstructive pulmonary disease is a major health problem becoming a leading cause of morbidity and mortality worldwide. a large part of these disorders is associated with acute exacerbations resulting from infection by bacteria, such as non-typeable haemophilus influenzae (nthi). our understanding of the pathogenesis of these exacerbations is still elusive. we demonstrate herein that nthi infection of mice chronically exposed to cigarette smoke (cs), an experimental model of chronic obstr ... | 2017 | 27143304 |
| distribution and diversity of hmw1a among invasive nontypeable haemophilus influenzae isolates in iran. | the pathogenesis of nontypeable haemophilus influenzae (nthi) begins with adhesion to the rhinopharyngeal mucosa. almost 38-80% of nthi clinical isolates produce proteins that belong to the high molecular weight (hmw) family of adhesins, which are believed to facilitate colonization. | 2017 | 27141269 |
| comparison of pcr-based methods for the simultaneous detection of neisseria meningitidis, haemophilus influenzae, and streptococcus pneumoniae in clinical samples. | several in-house pcr-based assays have been described for the detection of bacterial meningitis caused by neisseria meningitidis, streptococcus pneumoniae, and haemophilus influenzae from clinical samples. pcr-based methods targeting different bacterial genes are frequently used by different laboratories worldwide, but no standard method has ever been established. the aim of our study was to compare different in-house and a commercial pcr-based tests for the detection of bacterial pathogens caus ... | 2017 | 27256956 |
| identification of pathogens by comprehensive real-time pcr versus conventional methods in community-acquired pneumonia in japanese adults. | community-acquired pneumonia (cap) has high morbidity and mortality. unfortunately, the pathogen detection rate using conventional culture methods is relatively low. we compared comprehensive real-time polymerase chain reaction (real-time pcr) analysis of nasopharyngeal swab specimens (nps) and sputum samples against conventional methods for ability to detect causative pathogens of cap. | 2017 | 27329337 |
| seasonal patterns and association of meteorological factors with infection caused by streptococcus pneumoniae, haemophilus influenzae, and moraxella catarrhalis in childhood community-acquired pneumonia in a tropical region. | 2017 | 27464260 | |
| effects of prophylactic ibuprofen and paracetamol administration on the immunogenicity and reactogenicity of the 10-valent pneumococcal non-typeable haemophilus influenzae protein d conjugated vaccine (phid-cv) co-administered with dtpa-combined vaccines in children: an open-label, randomized, controlled, non-inferiority trial. | prophylactic paracetamol administration impacts vaccine immune response; this study ( www.clinicaltrials.gov : nct01235949) is the first to assess phid-cv immunogenicity following prophylactic ibuprofen administration. in this phase iv, multicenter, open-label, randomized, controlled, non-inferiority study in romania (november 2010-december 2012), healthy infants were randomized 3:3:3:1:1:1 to prophylactically receive immediate, delayed or no ibuprofen (iibu, dibu, nibu) or paracetamol (ipara, d ... | 2017 | 27541270 |
| purification and characterisation of anti-pneumococcal capsular polysaccharide igg immunoglobulins. | the production of reference materials for quantifying pneumococcal antibody concentrations relies upon large scale vaccination. an alternative simple, reproducible protocol has been developed for the affinity purification of 23 serotype anti-pneumococcal capsular polysaccharide (pcp) igg immunoglobulins. | 2017 | 27543805 |
| multiplexed instrument-free meningitis diagnosis on a polymer/paper hybrid microfluidic biochip. | neisseria meningitidis (n. meningitidis), streptococcus pneumoniae (s. pneumoniae), and haemophilus influenzae type b (hib) are three most common pathogens accounting for most bacterial meningitis, a serious global infectious disease with high fatality, especially in developing nations. because the treatment and antibiotics differ among each type, the identification of the exact bacteria causing the disease is vital. herein, we report a polymer/paper hybrid microfluidic biochip integrated with l ... | 2017 | 27657849 |
| synthesis of novel 15-membered 8a-azahomoerythromycin a acylides: consequences of structural modification at the c-3 and c-6 position on antibacterial activity. | a novel series of 6-o-substituted 8a-aza-8a-homoerythromycin a 3-o-acylides has been discovered with potent activity against key respiratory pathogens, including those inducibly and constitutively resistant to erythromycin. the best compounds in this series 15na and 15nd showed activity comparable to telithromycin, especially against haemophilus influenzae and constitutively mlsb-resistant strains of streptococcus pneumoniae and streptococcus pyogenes. furthermore, 15na exhibited a number of dru ... | 2017 | 27657812 |
| ulcerated giant dermatofibroma following routine childhood vaccination in a young boy. | the development of cutaneous neoplasms at immunization sites following vaccination is uncommon, and only few have been reported in the literature worldwide. we report an unusual case of an ulcerated giant dermatofibroma that developed as a chronic nonhealing plaque in the immunization scar of a young boy after vaccination. | 2017 | 27721753 |
| protection against vaccine preventable diseases in children treated for acute lymphoblastic leukemia. | the objective of this retrospective study was to assess protection against vaccine preventable diseases (vpds) in children treated for acute lymphoblastic leukemia (all). | 2017 | 27718310 |
| child pneumonia - focus on the western pacific region. | worldwide, pneumonia is the leading cause of death in infants and young children (aged <5 years). we provide an overview of the global pneumonia disease burden, as well as the aetiology and management practices in different parts of the world, with a specific focus on the who western pacific region. in 2011, the western pacific region had an estimated 0.11 pneumonia episodes per child-year with 61,900 pneumonia-related deaths in children less than 5 years of age. the majority (>75%) of pneumonia ... | 2017 | 27569107 |
| acute otitis media with spontaneous tympanic membrane perforation. | the principal aim of this review is to present the current knowledge regarding acute otitis media (aom) with spontaneous tympanic membrane perforation (stmp) and to address the question of whether aom with stmp is a disease with specific characteristics or a severe case of aom. pubmed was used to search for all studies published over the past 15 years using the key words "acute otitis media" and "othorrea" or "spontaneous tympanic membrane perforation". more than 250 articles were found, but onl ... | 2017 | 27677281 |
| low prevalence of kingella kingae carriage in children aged 6-48 months in sydney, australia. | a prospective observational study was conducted to estimate the prevalence of oropharyngeal carriage of kingella kingae in healthy australian pre-school children. | 2017 | 27669685 |
| a cross-sectional vaccination coverage study in preschool children attending nurseries-kindergartens: implications on economic crisis effect. | vaccination coverage studies are important in determining a population's vaccination status and strategically adjusting national immunization programs. this study assessed full and timely vaccination coverage of preschool children aged 2-3 y attending nurseries-kindergartens (n-k) nationwide at the socioeconomic crisis onset. geographically stratified cluster sampling was implemented considering prefectures as strata and n-k as clusters. the n-k were selected by simple random sampling from the s ... | 2017 | 27669156 |
| antibody persistence and immunologic memory in children vaccinated with 4 doses of pneumococcal conjugate vaccines: results from 2 long-term follow-up studies. | to investigate long-term antibody persistence following the administration of the 10-valent pneumococcal non-typeable haemophilus influenzae protein d conjugate vaccine (phid-cv), we present results of 2 follow-up studies assessing antibody persistence following 2 3+1 schedules up to 4 (nct00624819 - study a) and 5 years (nct00891176 - study b) post-booster vaccination. in study a, antibody persistence was measured one, 2 and 4 years post-booster in children previously primed and boosted with ph ... | 2017 | 27736293 |
| low and disparate seroprotection after pentavalent childhood vaccination in the lao people's democratic republic: a cross-sectional study. | in lao people's democratic republic, the high burden of vaccine-preventable diseases is thought to be mainly due to low vaccine coverage. we investigated the seroprotective response against diphtheria-tetanus-whole cell pertussis-hepatitis b-haemophilus influenzae type b (dtpw-hepb-hib) vaccine in children. | 2017 | 27756713 |
| imipenem heteroresistance in nontypeable haemophilus influenzae is linked to a combination of altered pbp3, slow drug influx and direct efflux regulation. | to investigate the potential roles of pbps, efflux pumps and slow drug influx for imipenem heteroresistance in nontypeable haemophilus influenzae (nthi). | 2017 | 27756711 |
| staphylococcus aureus carriage at admission predicts early-onset pneumonia after burn trauma. | early-onset pneumonia (eop) is frequent after burn trauma, increasing morbidity in the critical resuscitation phase, which may preclude early aggressive management of burn wounds. currently, however, preemptive treatment is not recommended. the aim of this study was to identify predictive factors for eop that may justify early empirical antibiotic treatment. data for all burn patients requiring ≥4 h mechanical ventilation (mv) who were admitted between january 2001 and october 2012 were extracte ... | 2017 | 27815777 |
| the spread and clinical impact of st14cc-pbp3 type iib/a, a clonal group of non-typeable haemophilus influenzae with chromosomally mediated β-lactam resistance-a prospective observational study. | increasing incidences of non-typeable haemophilus influenzae (nthi) with β-lactam resistance mediated through mutations in penicillin-binding protein 3 (blnar or rpbp3) have been observed in the past decades. recently, an rpbp3 nthi sequence type (st) 14 with pbp3 type iib/a caused a disease outbreak in a nursing home in sweden with severe outcomes, indicating increased bacterial virulence. in this prospective observational study, the epidemiology and clinical significance of the corresponding c ... | 2017 | 27852000 |
| overwhelming post-splenectomy sepsis in patients with asplenia and hyposplenia: a retrospective cohort study. | overwhelming post-splenectomy infection (opsi) is a serious complication of asplenia and is associated with encapsulated organisms, most commonly streptococcus pneumoniae, but also haemophilus influenzae and neisseria meningitidis. we aimed to estimate the risk of infection in this patient group. we reviewed data collected by the victorian spleen registry in australia. on registration, all patients are asked about significant infections requiring admission to hospital for intravenous antibiotics ... | 2017 | 27776576 |
| functional antibodies to haemophilus influenzae type b, neisseria meningitidis, and streptococcus pneumoniae contained in intravenous immunoglobulin products. | intravenous immunoglobulin g (ivig) replacement therapy is used to prevent invasive infections in patients with primary antibody deficiency (pad). however, few studies have functionally evaluated specific antibodies against encapsulated bacteria that cause invasive infection in patients with pad. in this study, functional antibodies against haemophilus influenzae type b (hib), streptococcus pneumoniae (pneumococci), and neisseria meningitidis (meningococci) in ivig therapy were evaluated. | 2017 | 27774610 |
| human lung fibroblasts present bacterial antigens to autologous lung th cells. | lung fibroblasts are key structural cells that reside in the submucosa where they are in contact with large numbers of cd4(+) th cells. during severe viral infection and chronic inflammation, the submucosa is susceptible to bacterial invasion by lung microbiota such as nontypeable haemophilus influenzae (nthi). given their proximity in tissue, we hypothesized that human lung fibroblasts play an important role in modulating th cell responses to nthi. we demonstrate that fibroblasts express the cr ... | 2017 | 27895174 |
| a naturally occurring single nucleotide polymorphism in a multicopy plasmid produces a reversible increase in antibiotic resistance. | cole1 plasmids are small mobilizable replicons that play an important role in the spread of antibiotic resistance in pasteurellaceae in this study, we describe how a natural single nucleotide polymorphism (snp) near the origin of replication of the cole1-type plasmid pb1000 found in a pasteurella multocida clinical isolate generates two independent plasmid variants able to coexist in the same cell simultaneously. using the haemophilus influenzae rd kw20 strain as a model system, we combined anti ... | 2017 | 27895020 |
| analysis of streptococcus pneumoniae and haemophilus influenzae isolated from middle ear fluid before and after the introduction of government subsidies for pneumococcal and h. influenzae type b vaccines in japan. | this study aimed to identify trends in frequency, serotype, and antimicrobial susceptibility of streptococcus pneumoniae and haemophilus influenzae isolated from middle ear fluid specimens of children aged≤15 years (mean, 2 years), before and after the introduction of the 7-valent pneumococcal conjugate vaccine (pcv7) and the h. influenzae type b vaccine, at a pediatric facility in japan. sixty-six s. pneumoniae and 88 h. influenzae strains were isolated from 820 middle ear fluid samples. seroty ... | 2017 | 27889249 |
| multiplex pcr reveals that viruses are more frequent than bacteria in children with cystic fibrosis. | cystic fibrosis is a degenerative disease characterized by progressive epithelial secretory gland dysfunction associated with repeated respiratory infections. bacterial infections are very frequent in children with cystic fibrosis, but because rapid methods: for screening for the wide variety of potentially involved viruses were unavailable until recently, the frequency of viral presence is unknown. multiplex pcr enables screening for many viruses involved in respiratory infections. | 2017 | 27886635 |
| rise in haemophilus influenzae with reduced quinolone susceptibility and development of a simple screening method. | β-lactamase-nonproducing ampicillin-resistant haemophilus influenzae are prevalent in japan. resistance has increased as a consequence of the expanded use of antimicrobial agents, raising concerns about the rise of multidrug (macrolide and fluoroquinolone)-resistant h. influenzae. | 2017 | 27870809 |
| study of greek children and youths with cystic fibrosis identifies immunisation gaps and delays. | data about immunisation rates in cystic fibrosis (cf) patients are scarce. we estimated the rates and timeliness of immunisations in cf patients aged 0.55-22 years. | 2017 | 27862309 |
| bacteremic renal stone-associated urinary tract infection caused by nontypable haemophilus influenzae: a rare invasive disease in an immunocompetent patient. | haemophilus species are known to colonize the upper respiratory tract and can cause infections. however haemophilus influenzae has been rarely described as a cause of genitourinary tract infection. we report a 44-year-old nonimmunocompromised japanese man with bacteremic pyelonephritis caused by a nontypable h. influenzae associated with a left ureteral calculus. the organism was isolated from both blood and urine cultures. treatment consisted of 14 days of intravenous ceftriaxone and oral amoxi ... | 2017 | 27920983 |
| n-acetyl-l-cysteine and cysteamine as new strategies against mixed biofilms of nonencapsulated streptococcus pneumoniae and nontypeable haemophilus influenzae. | acute otitis media, a polymicrobial disease of the middle ear cavity of children, is a significant public health problem worldwide. it is most frequently caused by encapsulated streptococcus pneumoniae and nontypeable haemophilus influenzae, although the widespread use of pneumococcal conjugate vaccines is apparently producing an increase in the carriage of nonencapsulated s. pneumoniae frequently, pneumococci and h. influenzae live together in the human nasopharynx, forming a self-produced biof ... | 2017 | 27919900 |
| cephalosporin-3'-diazeniumdiolate no donor prodrug pyrro-c3d enhances azithromycin susceptibility of nontypeable haemophilus influenzae biofilms. | pyrro-c3d is a cephalosporin-3-diazeniumdiolate nitric oxide (no) donor prodrug designed to selectively deliver no to bacterial infection sites. the objective of this study was to assess the activity of pyrro-c3d against nontypeable haemophilus influenzae (nthi) biofilms and examine the role of no in reducing biofilm-associated antibiotic tolerance. the activity of pyrro-c3d on in vitro nthi biofilms was assessed through cfu enumeration and confocal microscopy. no release measurements were perfo ... | 2017 | 27919896 |
| etiology of acute otitis media in children less than 5 years of age: a pooled analysis of 10 similarly designed observational studies. | acute otitis media (aom) is an important cause of childhood morbidity and antibiotic prescriptions. however, the relative importance of the well-known otopathogens, streptococcus pneumoniae (spn) and haemophilus influenzae (hflu), remains unclear because of a limited number of tympanocentesis-based studies that vary significantly in populations sampled, case definitions and heptavalent pneumococcal conjugate vaccine use. | 2017 | 27918383 |
| concomitant administration of a fully liquid, ready-to-use dtap-ipv-hb-prp-t hexavalent vaccine with a meningococcal serogroup c conjugate vaccine in infants. | dtap-ipv-hb-prp-t or hexavalent vaccines are indicated for primary and booster vaccination of infants and toddlers against diphtheria, tetanus, pertussis, hepatitis b, poliomyelitis and invasive diseases caused by haemophilus influenzae type b (hib). the present study evaluates the safety and immunogenicity of a ready-to-use hexavalent vaccine when co-administered with a meningococcal serogroup c conjugate (menc) vaccine in infants. this was a phase iii, open-label, randomised, multicentre study ... | 2017 | 27939054 |
| emergence of quinolone-resistant strains in streptococcus pneumoniae isolated from paediatric patients since the approval of oral fluoroquinolones in japan. | tosufloxacin (tflx) is a fluoroquinolone antimicrobial agent. tflx granules for children were initially released in japan in 2010 to treat otitis media and pneumonia caused by drug-resistant bacteria, e.g. penicillin-resistant streptococcus pneumoniae and beta-lactamase-negative, ampicillin-resistant haemophilus influenzae. the evolution of bacterial resistance since tflx approval is not known. to clarify the influence of quinolones administered to children since their approval, we examined the ... | 2017 | 28159338 |
| haemophilus influenzae serotype f epiglottitis: a case report and review. | 2017 | 28028010 | |
| recent epidemiology of streptococcus pneumoniae in nasopharynxes of korean children with acute otitis media. | this prospective study was performed to evaluate serotype distribution, multilocus sequence typing, and antibiotic susceptibility of streptococcus pneumoniae identified in korean children with acute otitis media (aom) after the introduction of a 7-valent pneumococcal conjugate vaccine (pcv7). | 2017 | 28024738 |
| emergence and molecular characterization of haemophilus influenzae harbouring mef(a). | 2017 | 27999037 | |
| pneumonia prevention: cost-effectiveness analyses of two vaccines among refugee children aged under two years, haemophilus influenzae type b-containing and pneumococcal conjugate vaccines, during a humanitarian emergency, yida camp, south sudan. | by september 2013, war between sudan and south sudan resulted in >70,000 sudanese refugees and high pneumonia incidence among the 20,000 refugees in yida camp, south sudan. using médecins sans frontières (msf)-provided data and modifying our decision-tree models, we estimated if administering haemophilus influenzae type b (hib)-containing (pentavalent vaccine, also with diphtheria pertussis and tetanus [dpt] and hepatitis b) and pneumococcal conjugate (pcv) vaccines were cost-effective against h ... | 2017 | 27989625 |
| antimicrobial activity of antisense peptide-peptide nucleic acid conjugates against non-typeable haemophilus influenzae in planktonic and biofilm forms. | antisense peptide nucleic acids (pnas) are synthetic polymers that mimic dna/rna and inhibit bacterial gene expression in a sequence-specific manner. | 2017 | 27986898 |
| haemophilus influenzae type b invasive disease in amish children, missouri, usa, 2014. | during 5 months in 2014, three amish children in missouri, usa, were diagnosed with invasive haemophilus influenzae type b infection. two were rural neighbors infected with a genetically similar rare strain, sequence type 45. one child had recently traveled, raising the possibility of maintenance of this strain among unvaccinated carriers in amish communities. | 2017 | 27983486 |
| resistance of non-typeable haemophilus influenzae biofilms is independent of biofilm size. | the inflammatory middle ear disease known as otitis media can become chronic or recurrent in some cases due to failure of the antibiotic treatment to clear the bacterial etiological agent. biofilms are known culprits of antibiotic-resistant infections; however, the mechanisms of resistance for non-typeable haemophilus influenzae biofilms have not been completely elucidated. in this study, we utilized in vitro static biofilm assays to characterize clinical strain biofilms and addressed the hypoth ... | 2017 | 27956464 |
| bacterial lysis through interference with peptidoglycan synthesis increases biofilm formation by nontypeable haemophilus influenzae. | nontypeable haemophilus influenzae (nthi) is an opportunistic pathogen that mainly causes otitis media in children and community-acquired pneumonia or exacerbations of chronic obstructive pulmonary disease in adults. a large variety of studies suggest that biofilm formation by nthi may be an important step in the pathogenesis of this bacterium. however, the underlying mechanisms involved in this process are poorly elucidated. in this study, we used a transposon mutant library to identify bacteri ... | 2017 | 28124027 |
| pediatric endogenous haemophilus influenzae endophthalmitis with presumed hyposplenism. | endogenous bacterial endophthalmitis is a rare but potentially devastating intraocular infection that can have severe sight-threatening complications. most patients with endogenous bacterial endophthalmitis have underlying infectious conditions, such as diabetes or malignancy, which predispose them to infection. | 2017 | 28115875 |
| prospective evaluation of the aetiology of acute otitis media with spontaneous tympanic membrane perforation. | to evaluate the aetiological role of the main bacterial pathogens associated with acute otitis media (aom) in children with aom and spontaneous tympanic membrane perforation (stmp). | 2017 | 28110050 |
| first complete genome sequence of haemophilus influenzae serotype a. | haemophilus influenzae is an important human pathogen that primarily infects small children. in recent years, h. influenzae serotype a has emerged as a significant cause of invasive disease among indigenous populations. here, we present the first complete whole-genome sequence of h. influenzae serotype a. | 2017 | 28104664 |
| the national swedish immunisation programme includes vaccine against diphtheria, tetanus, polio, pertussis, haemophilus influenzae type b, pneumococcus as well as measles, mumps and rubella. data were collected on hospital admissions for children 0- 17 years of age of vaccine-preventable diseases during 2008-2013 at astrid lindgren children's hospital, stockholm. patients were identified by discharge diagnosis codes as well as from the clinical microbiology laboratory. there were rare cases of m ... | 2017 | 28094831 | |
| budget impact analysis of vaccination against haemophilus influenzae type b as a part of a pentavalent vaccine in the childhood immunization schedule of iran. | health decision makers need to know the impact of the development of a new intervention on the public health and health care costs so that they can plan for economic and financial objectives. the aim of this study was to determine the budget impact of adding haemophilus influenzae type b (hib) as a part of a pentavalent vaccine (hib-hbv-dtp) to the national childhood immunization schedule of iran. | 2017 | 28088246 |
| vaccine candidates against nontypeable haemophilus influenzae: a review | nonencapsulated, nontypeable hemophilus influenzae (nthi) remains an important cause of acute otitis and respiratory diseases in children and adults. nthi bacteria are one of the major causes of respiratory tract infections, including acute otitis media, cystic fibrosis, and community-acquired pneumonia among children, especially in developing countries. the bacteria can also cause chronic diseases such as chronic bronchitis and chronic obstructive pulmonary disease in the lower respiratory trac ... | 2017 | 28088130 |
| aqueous humor antimicrobial activity: in vitro analysis after topical 0.5% chloramphenicol application. | to assess aqueous humor antimicrobial activity in vitro after topical 0.5% chloramphenicol application. | 2017 | 28085501 |
| vaccination with 10-valent pneumococcal conjugate vaccine in infants according to hiv status. | phase iii, open-label, single-center, controlled study in south africa (clinicaltrials.gov: nct00829010) to evaluate immunogenicity, reactogenicity, and safety of the 10-valent pneumococcal non-typeable haemophilus influenzae protein d conjugate vaccine (phid-cv) in human immunodeficiency virus (hiv)-infected (hiv+), hiv-exposed-uninfected (heu), and hiv-unexposed-uninfected (huu) children. | 2017 | 28079828 |
| nasopharyngeal carriage of respiratory pathogens in warao amerindians: significant relationship with stunting. | to assess risk factors for nasopharyngeal carriage of potential pathogens in geographically isolated warao amerindians in venezuela. | 2017 | 28072501 |
| response to effectiveness of the 10-valent pneumococcal nontypeable haemophilus influenzae protein d-conjugated vaccine (phid-cv) against carriage and acute otitis media-a double-blind randomized clinical trial in finland. | 2017 | 28064237 | |
| the main rhinovirus respiratory tract adhesion site (icam-1) is upregulated in smokers and patients with chronic airflow limitation (cal). | icam-1 is a major receptor for ~60% of human rhinoviruses, and non-typeable haemophilus influenzae, two major pathogens in copd. increased cell-surface expression of icam-1 in response to tobacco smoke exposure has been suggested. we have investigated epithelial icam-1 expression in both the large and small airways, and lung parenchyma in smoking-related chronic airflow limitation (cal) patients. | 2017 | 28056984 |
| haemophilus species as a urinary tract pathogen. | haemophilus species, as a urinary tract pathogen, is rarely encountered. routine urine culture pathogens are well documented to include enterobacteriaciae, enterococcus spp., staphylococcus spp., pseudomonas spp., and candida spp. pathogens encountered rarely in this context may include corynebacterium ureolyticus and nonfermenting gram negative bacilli. this case study involves the finding of haemophilus influenzae in a urine culture performed on a 4-year-old caucasian girl and haemophilus pari ... | 2017 | 28039378 |
| australian aboriginal children with otitis media have reduced antibody titers to specific nontypeable haemophilus influenzae vaccine antigens. | indigenous populations experience high rates of otitis media (om), with increased chronicity and severity, compared to those experienced by their nonindigenous counterparts. data on immune responses to otopathogenic bacteria in these high-risk populations are lacking. nontypeable haemophilus influenzae (nthi) is the predominant otopathogen in australia. no vaccines are currently licensed to target nthi; however, protein d (pd) from nthi is included as a carrier protein in the 10-valent pneumococ ... | 2017 | 28151410 |
| prelp enhances host innate immunity against the respiratory tract pathogen moraxella catarrhalis. | respiratory tract infections are one of the leading causes of mortality worldwide urging better understanding of interactions between pathogens causing these infections and the host. here we report that an extracellular matrix component proline/arginine-rich end leucine-rich repeat protein (prelp) is a novel antibacterial component of innate immunity. we detected the presence of prelp in human bronchoalveolar lavage fluid and showed that prelp can be found in alveolar fluid, resident macrophages ... | 2017 | 28148731 |
| epidemiology of otitis media with spontaneous perforation of the tympanic membrane in young children and association with bacterial nasopharyngeal carriage, recurrences and pneumococcal vaccination in catalonia, spain - the prospective hermes study. | the epidemiology of otitis media with spontaneous perforation of the tympanic membrane and associated nasopharyngeal carriage of bacterial otopathogens was analysed in a county in catalonia (spain) with pneumococcal conjugate vaccines (pcvs) not included in the immunization programme at study time. a prospective, multicentre study was performed in 10 primary care centres and 2 hospitals (june 2011-june 2014), including all otherwise healthy children ≥2 months ≤8 years with otitis media presentin ... | 2017 | 28146590 |
| antibiotic susceptibility and molecular analysis of invasive haemophilus influenzae in canada, 2007 to 2014. | previously we studied the antibiotic susceptibility of invasive haemophilus influenzae collected in canada from 1990 to 2006 and characterized isolates by serotype, mlst and ftsi gene sequencing for significant pbp3 mutations. | 2017 | 28137937 |
| from immunologically archaic to neoteric glycovaccines. | polysaccharides (ps) are present in the outermost surface of bacteria and readily come in contact with immune cells. they interact with specific antibodies, which in turn confer protection from infections. vaccines with ps from pneumococci, meningococci, haemophilus influenzae type b, and salmonella typhi may be protective, although with the important constraint of failing to generate permanent immunological memory. this limitation has in part been circumvented by conjugating glycovaccines to pr ... | 2017 | 28134792 |
| diesel exhaust alters the response of cultured primary bronchial epithelial cells from patients with chronic obstructive pulmonary disease (copd) to non-typeable haemophilus influenzae. | exacerbations constitute a major cause of morbidity and mortality in patients suffering from chronic obstructive pulmonary disease (copd). both bacterial infections, such as those with non-typeable haemophilus influenzae (nthi), and exposures to diesel engine emissions are known to contribute to exacerbations in copd patients. however, the effect of diesel exhaust (de) exposure on the epithelial response to microbial stimulation is incompletely understood, and possible differences in the respons ... | 2017 | 28129777 |
| comparison of serotype prevalence of pneumococci isolated from middle ear, lower respiratory tract and invasive disease prior to vaccination in iceland. | information on pneumococcal serotype distribution before vaccination is a prerequisite for evaluation of vaccine effect. the aim was to investigate the prevalence of pneumococcal serotypes isolated from middle ear (me), lower respiratory tract (lrt) and from invasive disease (ipd) in iceland prior to implementation of ten-valent pneumococcal haemophilus influenzae protein d conjugate vaccine (phid-cv-10) into the infant vaccination program (april 2011). | 2017 | 28125588 |
| diagnosis of primary antibody and complement deficiencies in young adults after a first invasive bacterial infection. | screening for primary immunodeficiencies (pids) in adults is recommended after two severe bacterial infections. we aimed to evaluate if screening should be performed after the first invasive infection in young adults. | 2017 | 28192236 |
| adherence to vaccination guidelines post splenectomy: a five year follow up study. | following a splenectomy patients are at increased risk of significant infections. in its most severe form, overwhelming post-splenectomy infection (opsi) has a mortality rate of up to 80%. in this study we aim to establish the adherence to vaccination and antibiotic national guidelines in splenectomised patients. a retrospective study of 100 patients who underwent splenectomy (21 emergency, 79 elective), in two teaching hospitals was undertaken over a five-year period. patients were followed up ... | 2017 | 28189514 |
| do we need a vaccine against moraxella catarrhalis in chronic lung disease? what are the options and opportunities? | moraxella catarrhalis is the second most common cause of exacerbations in adults with copd, resulting in enormous morbidity and mortality in this clinical setting. vaccine development for m. catarrhalis has lagged behind the other two important causes of exacerbations in copd, nontypeable haemophilus influenzae and streptococcus pneumoniae. while no licensed vaccine is currently available for m. catarrhalis, several promising candidate vaccine antigens have been identified and characterized and ... | 2017 | 28185742 |
| modeling the potential for vaccination to diminish the burden of invasive non-typhoidal salmonella disease in young children in mali, west africa. | in sub-saharan africa, systematic surveillance of young children with suspected invasive bacterial disease (e.g., septicemia, meningitis) has revealed non-typhoidal salmonella (nts) to be a major pathogen exhibiting high case fatality (~20%). where infant vaccination against haemophilus influenzae type b (hib) and streptococcus pneumoniae has been introduced to prevent invasive disease caused by these pathogens, as in bamako, mali, their burden has decreased markedly. in parallel, nts has become ... | 2017 | 28182657 |
| serum resistance and phase variation of a nasopharyngeal non-typeable haemophilus influenzae isolate. | haemophilus influenzae harbours a complex array of factors to resist human complement attack. as non-typeable h. influenzae (nthi) strains do not possess a capsule, their serum resistance mainly depends on other mechanisms including los decoration. in this report, we describe the identification of a highly serum resistant, nasopharyngeal isolate (nthi23) by screening a collection of 77 clinical isolates. for nthi23, we defined the mlst sequence type 1133, which matches the profile of a previousl ... | 2017 | 28179078 |
| invasive haemophilus influenzae infection in patients with cancer. | a major cause of morbidity and mortality in patients with cancer is infection. since the introduction of the haemophilus influenzae type b (hib) vaccine in the united states in the 1990s, invasive h influenzae infection has become less common. we report on 5 patients with cancer and invasive h influenzae infection. a literature review was also performed of the dominant haemophilus subtype and the clinical features associated with the infection and concomitant cancer. of the 17 cases found in the ... | 2017 | 28178716 |
| the impact of prenatal exposure to parasitic infections and to anthelminthic treatment on antibody responses to routine immunisations given in infancy: secondary analysis of a randomised controlled trial. | chronic parasitic infections are associated with active immunomodulation which may include by-stander effects on unrelated antigens. it has been suggested that pre-natal exposure to parasitic infections in the mother impacts immunological development in the fetus and hence the offspring's response to vaccines, and that control of parasitic infection among pregnant women will therefore be beneficial. | 2017 | 28178298 |
| etiology of acute otitis media and serotype distribution of streptococcus pneumoniae and haemophilus influenzae in chilean children <5 years of age. | the impact of bacterial conjugate vaccines on acute otitis media (aom) is affected by several factors including population characteristics, bacterial etiology and vaccine conjugation method, carrier, and coverage. this study estimated the baseline etiology, distribution, and antibiotic susceptibility of bacterial serotypes that causes aom in children aged <5 years in a public setting in santiago, chile.children aged ≥3 months and <5 years referred to the physician for treatment of aom episodes ( ... | 2017 | 28178138 |
| the crystal structure of pd1, a haemophilus surface fibril domain. | the haemophilus surface fibril (hsf) is an unusually large trimeric autotransporter adhesin (taa) expressed by the most virulent strains of h. influenzae. hsf is known to mediate adhesion between pathogen and host, allowing the establishment of potentially deadly diseases such as epiglottitis, meningitis and pneumonia. while recent research has suggested that this taa might adopt a novel `hairpin-like' architecture, the characterization of hsf has been limited to in silico modelling and electron ... | 2017 | 28177321 |
| antibacterial defense of human airway epithelial cells from chronic obstructive pulmonary disease patients induced by acute exposure to nontypeable haemophilus influenzae: modulation by cigarette smoke. | antimicrobial proteins and peptides (amps) are a central component of the antibacterial activity of airway epithelial cells. it has been proposed that a decrease in antibacterial lung defense contributes to an increased susceptibility to microbial infection in smokers and patients with chronic obstructive pulmonary disease (copd). however, whether reduced amp expression in the epithelium contributes to this lower defense is largely unknown. we investigated the bacterial killing activity and expr ... | 2017 | 28171878 |